Web Desc
Host Response in Tuberculosis
joint with Tuberculosis: Understanding the Enemy
Organizer(s): Andrea M. Cooper and Robert J. Wilkinson
Date: March 13 - 18, 2013
Location: Whistler Conference Centre, Whistler, BC, Canada
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Although the host response to tuberculosis has been studied for many years, we still have only a rudimentary working model of the disease process; namely that antigen-specific T cells activate infected macrophages to control bacterial growth. Further progress in the control of tuberculosis will depend on a much more detailed understanding of the nature of the host response to infection. Therefore, the purpose of this Keystone Symposia meeting is to reassess our current understanding of disease mechanisms, discuss the most recent advances in the field, and identify critical questions and future research directions. A key focus of the meeting will be the innate, acquired, and immunopathologic responses that occur in the host following exposure to Mycobacterium tuberculosis. Speakers will be strongly encouraged to move past dogma and promote critical re-analysis of our working model of what constitutes protective immunity to tuberculosis. The conference will be held concurrently with a meeting on Tuberculosis: Understanding the Enemy – covering bacterial genetics, bacterial physiology, systems biology, and drug development. This will provide opportunities for participants from different disciplines to interact with one another forge new collaborations in novel areas of biology. Importantly, the interactive nature of the meetings will promote the new ideas and novel approaches necessary to combat this devastating disease.
Scholarship Deadline: November 13 2012
Discounted Abstract Deadline: November 13 2012
Abstract Deadline: December 11 2012
Discounted Registration Deadline: January 14 2013
Abstacts when book is in proofing process


$2,500 - $9,999
S. Karger AG - Respiration
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
S. Karger AG - Respiration
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI104041-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, March 13 | 4:00PM - 8:00PM
Arrival and Registration
Room: Grand Foyer


Thursday, March 14 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A, Garibaldi B/C


Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 1 of 7
* David G. Russell, Cornell University, USA

Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 2 of 7
Larry S. Schlesinger, Texas Biomedical Research Institute, USA
Unique Immunoregulatory Factors in the Lung Alveolus during the Early Microbe-Host Encounter

Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 3 of 7
Helen A. Fletcher, London School of Hygiene and Tropical Medicine, UK
Correlates of Risk of TB Disease in Infants Vaccinated with BCG

Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 4 of 7
Jennifer Philips, Washington University School of Medicine, USA
EsxH ESCRTs TB to Safety by Arresting Phagosome Maturation

Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 5 of 7
Ishita Bhattacharya, Garvan Institute for Medical Research, Australia
Short Talk: The Splice Variant of IL-12Rbeta1: A New Player in the IL-12 Signaling Network

Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 6 of 7
Cliona M. Ni Cheallaigh, Trinity College Dublin, Ireland
Short Talk: My-D88 Adapter Like (Mal) Is Required for Effective Macrophage Responses to Mycobacterium tuberculosis

Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 7 of 7
Alissa C. Rothchild, Seattle Children's Research Institute, USA
Short Talk: iNKT Cell Production of GM-CSF Inhibits Growth of Mycobacterium tuberculosis

Thursday, March 14 | 8:00AM - 11:00AM
Mycobacterium tuberculosis – From Single Cells to Systems
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 1 of 6
* Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA


Thursday, March 14 | 8:00AM - 11:00AM
Mycobacterium tuberculosis – From Single Cells to Systems
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 2 of 6
Heran Darwin, New York University School of Medicine, USA
Pedal to the Metal: Copper Resistance in Mycobacterium tuberculosis


Thursday, March 14 | 8:00AM - 11:00AM
Mycobacterium tuberculosis – From Single Cells to Systems
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 3 of 6
Bree B. Aldridge, Tufts University, USA
Short Talk: Back to Basics: Diversity through Growth and Division in Mycobacteria


Thursday, March 14 | 8:00AM - 11:00AM
Mycobacterium tuberculosis – From Single Cells to Systems
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 4 of 6
Veronique Anne Dartois, Hackensack Meridian Health, USA
Pharmacology: The Fate of TB Drugs from Plasma to Lesions and Single Cells


Thursday, March 14 | 8:00AM - 11:00AM
Mycobacterium tuberculosis – From Single Cells to Systems
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 5 of 6
Johnjoe McFadden, University of Surrey, UK
Systems-Based Metabolic Analysis of Intracellular Growth of the TB bacillus


Thursday, March 14 | 8:00AM - 11:00AM
Mycobacterium tuberculosis – From Single Cells to Systems
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 6 of 6
Dany J. V. Beste, University of Surrey, UK
Short Talk: 13C Isotopomer Spectral Analysis of Cholesterol Metabolism by Mycobacterium tuberculosis Growing in vitro and within Macrophages


Thursday, March 14 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Thursday, March 14 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Thursday, March 14 | 11:00AM - 3:30PM
On Own for Lunch and Recreation


Thursday, March 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Thursday, March 14 | 3:30PM - 4:00PM
Coffee Available
Room: Grand Foyer


Thursday, March 14 | 4:00PM - 5:00PM
Keynote Address - TB: The Continuing Challenge (Joint)
Room: Sea to Sky B/C

Speaker 1 of 2
* Andrea M. Cooper, University of Leicester, UK

Thursday, March 14 | 4:00PM - 5:00PM
Keynote Address - TB: The Continuing Challenge (Joint)
Room: Sea to Sky B/C

Speaker 2 of 2
Chris Dye, World Health Organization, Switzerland
TB: The Continuing Challenge

Thursday, March 14 | 5:00PM - 7:00PM
How Do Innate Cells Respond to Mtb (II) (Joint)
Room: Sea to Sky B/C
Mononuclear phagocytes are recognized as the host cells for Mtb but what do they really do? Neutrophils have been largely ignored as actors in tuberculosis, what do these cells do to contribute to disease? This session addresses these questions.
Speaker 1 of 3
Carl F. Nathan, Weill Cornell Medical College, USA
Can Macrophages Be Super-Activated?

Thursday, March 14 | 5:00PM - 7:00PM
How Do Innate Cells Respond to Mtb (II) (Joint)
Room: Sea to Sky B/C
Mononuclear phagocytes are recognized as the host cells for Mtb but what do they really do? Neutrophils have been largely ignored as actors in tuberculosis, what do these cells do to contribute to disease? This session addresses these questions.
Speaker 2 of 3
Anne O'Garra, Francis Crick Institute, UK
Systems Approach to Understand the Immune Response in Tuberculosis

Thursday, March 14 | 5:00PM - 7:00PM
How Do Innate Cells Respond to Mtb (II) (Joint)
Room: Sea to Sky B/C
Mononuclear phagocytes are recognized as the host cells for Mtb but what do they really do? Neutrophils have been largely ignored as actors in tuberculosis, what do these cells do to contribute to disease? This session addresses these questions.
Speaker 3 of 3
David G. Russell, Cornell University, USA
Chemical and Genetic Perturbation of the Intracellular Survival Strategies of Mycobacterium tuberculosis

Thursday, March 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Thursday, March 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A


Friday, March 15 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A, Garibaldi B/C


Friday, March 15 | 8:00AM - 11:00AM
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradig
m?

Room: Sea to Sky B
While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.
Speaker 1 of 6
Eric G. Pamer, University of Chicago, USA
Ly6Chi Monocytes and Immune Defense Against Mycobacterium tuberculosis Infection

Friday, March 15 | 8:00AM - 11:00AM
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradig
m?

Room: Sea to Sky B
While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.
Speaker 2 of 6
* Samuel M. Behar, University of Massachusetts Medical School, USA
CD8+ T Cells and Protective Immunity to Tuberculosis

Friday, March 15 | 8:00AM - 11:00AM
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradig
m?

Room: Sea to Sky B
While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.
Speaker 3 of 6
Krishna Vankayalapati, University of Texas Health Center, USA
Short Talk: A Subpopulation of CD4+CD25+Foxp3+ T-Cells Inhibits Growth of Mycobacterium tuberculosis

Friday, March 15 | 8:00AM - 11:00AM
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradig
m?

Room: Sea to Sky B
While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.
Speaker 4 of 6
Peter L. Andersen, Statens Serum Institut, Denmark
Vaccine Induced Protection Against TB

Friday, March 15 | 8:00AM - 11:00AM
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradig
m?

Room: Sea to Sky B
While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.
Speaker 5 of 6
Albanus Moguche, Seattle Biomed, USA
Short Talk: Intrinsic CXCR5 Expression Is Required to Maintain Antigen Specific CD4 T Cells during Chronic Mycobacterium tuberculosis Infection

Friday, March 15 | 8:00AM - 11:00AM
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradig
m?

Room: Sea to Sky B
While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.
Speaker 6 of 6
Shabaana Khader, Washington University School of Medicine, USA
Short Talk: Interleukin-17 Mediates Vaccine-Induced Immunity Against Tuberculosis

Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 1 of 7
* Graham F. Hatfull, University of Pittsburgh, USA


Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 2 of 7
Nico C. Gey van Pittius, University of Stellenbosch, South Africa
Evolution of the PE and PPE Multi-Gene Families in the Mycobacteria


Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 3 of 7
Thomas Ioerger, Texas A&M University, USA
What Comparative Genomics of Mycobacteria can Tell Us about Drug Resistance


Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 4 of 7
Jeffery S. Cox, University of California, Berkeley, USA
The Ubiquitin Ligase PARKIN Is Required for Autophagy and Host Resistance to Intracellular Pathogens


Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 5 of 7
Basim R.K. Al Shammari, Imperial College London, UK
Short Talk: Infection of MMP-1 Transgenic Mice with Virulent Mycobacterium tuberculosis Causes Human-Type Lung Pathology


Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 6 of 7
Mireia Coscolla, Swiss Tropical and Public Health Institute, Switzerland
Short Talk: Adaptive Evolution in Different Lineages of the Mycobacterium tuberculosis Complex


Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 7 of 7
Christophe Guilhot, Centre National de la Recherche Scientifique, France
Short Talk: Do Polymorphisms in phoPR Explain the Lower Virulence for Humans of africanum and Animal Strains of the Mycobacterium tuberculosis Complex?


Friday, March 15 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Friday, March 15 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Friday, March 15 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Friday, March 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Friday, March 15 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility (Joint)
Room: Sea to Sky B/C

Speaker 1 of 8
* Hardy Kornfeld, University of Massachusetts Medical School, USA

Friday, March 15 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility (Joint)
Room: Sea to Sky B/C

Speaker 2 of 8
Thuong T. T. Nguyen, Oxford University Clinical Research Unit, Vietnam
A Genome–Wide Association Analysis Investigating the Contribution of Human and M. tuberculosis Genetics on Tuberculous Meningitis Susceptibility

Friday, March 15 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility (Joint)
Room: Sea to Sky B/C

Speaker 3 of 8
Anna Kathleen Coussens, Walter and Eliza Hall Institute, Australia
Ethnicity Has a Greater Effect than Mycobacterial Lineage on the Identification of Biomarkers for TB

Friday, March 15 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility (Joint)
Room: Sea to Sky B/C

Speaker 4 of 8
Joseph Keane, Trinity College Dublin, Ireland
Cigarette Smoking Impairs Human Pulmonary Tuberculosis Immunity

Friday, March 15 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility (Joint)
Room: Sea to Sky B/C

Speaker 5 of 8
Randall J. Basaraba, Colorado State University, USA
Altered Systemic Metabolism Contributes to TB Pathogenesis

Friday, March 15 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility (Joint)
Room: Sea to Sky B/C

Speaker 6 of 8
Nathella Pavan Kumar, National Institute for Research in Tuberculosis, India
Expansion of Pathogen - Specific Th1 and Th17 Cells in Pulmonary Tuberculosis with Coincident Type 2 Diabetes Mellitus

Friday, March 15 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility (Joint)
Room: Sea to Sky B/C

Speaker 7 of 8
Susan Realegeno, University of California, Los Angeles, USA
The Role of Vitamin D in IFN-gamma Induced Antimicrobial Responses Against Mycobacterium Infection in Human Macrophages

Friday, March 15 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility (Joint)
Room: Sea to Sky B/C

Speaker 8 of 8
Philip Liu, University of California, Los Angeles, USA
Vitamin A Triggers a Human Antimicrobial Response Dependent on Cellular Cholesterol Composition

Friday, March 15 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Friday, March 15 | 5:00PM - 7:00PM
Vaccination Against Mtb (Joint)
Room: Sea to Sky B/C
The availability of patients in close proximity to high tech tools for analysis of immune responses has resulted in an increase in our understanding of the human response to Mtb infection.
Speaker 1 of 4
* Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands

Friday, March 15 | 5:00PM - 7:00PM
Vaccination Against Mtb (Joint)
Room: Sea to Sky B/C
The availability of patients in close proximity to high tech tools for analysis of immune responses has resulted in an increase in our understanding of the human response to Mtb infection.
Speaker 2 of 4
Alessandro Sette, La Jolla Institute for Immunology, USA
Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed Against Three Antigenic Islands and Largely Contained in a CXCR3+CCR6+ Th1 Subset

Friday, March 15 | 5:00PM - 7:00PM
Vaccination Against Mtb (Joint)
Room: Sea to Sky B/C
The availability of patients in close proximity to high tech tools for analysis of immune responses has resulted in an increase in our understanding of the human response to Mtb infection.
Speaker 3 of 4
Thomas Evans, TomegaVax, USA
Early Results of Vaccine Trials in Humans

Friday, March 15 | 5:00PM - 7:00PM
Vaccination Against Mtb (Joint)
Room: Sea to Sky B/C
The availability of patients in close proximity to high tech tools for analysis of immune responses has resulted in an increase in our understanding of the human response to Mtb infection.
Speaker 4 of 4
Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Vaccination Against Tuberculosis: Back to Basic Research or Forward with Clinical Trials?

Friday, March 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Friday, March 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Saturday, March 16 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A, Garibaldi B/C


Saturday, March 16 | 8:00AM - 11:00AM
The Consequences of the Immune Response in the Lung
Room: Sea to Sky B
Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.
Speaker 1 of 6
Denise Kirschner, University of Michigan, USA
A Systems Biology Approach to Uncovering Mechanisms Governing Host-Mycobacterial Interactions during TB Infection in the Lung and Lymph Nodes

Saturday, March 16 | 8:00AM - 11:00AM
The Consequences of the Immune Response in the Lung
Room: Sea to Sky B
Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.
Speaker 2 of 6
Clifton E. Barry III, NIAID, National Institutes of Health, USA
The Dynamics of Human Tuberculosis

Saturday, March 16 | 8:00AM - 11:00AM
The Consequences of the Immune Response in the Lung
Room: Sea to Sky B
Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.
Speaker 3 of 6
Robert J. Francis, University of Surrey, UK
Short Talk: Selective ESAT6-Dependent Necrosis of Phosphatidylserine Externalised Neutrophils

Saturday, March 16 | 8:00AM - 11:00AM
The Consequences of the Immune Response in the Lung
Room: Sea to Sky B
Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.
Speaker 4 of 6
* Jon Friedland, Imperial College London, UK
Matrix Metalloproteinases in Tuberculosis

Saturday, March 16 | 8:00AM - 11:00AM
The Consequences of the Immune Response in the Lung
Room: Sea to Sky B
Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.
Speaker 5 of 6
Manuela Flórido, Centenary Institute, Australia
Short Talk: Influenza A Virus Infection Impairs Mycobacteria-Specific T Cell Responses and Mycobacterial Clearance in the Lung during Pulmonary Co-Infection

Saturday, March 16 | 8:00AM - 11:00AM
The Consequences of the Immune Response in the Lung
Room: Sea to Sky B
Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.
Speaker 6 of 6
Melanie J. Harriff, Oregon Health & Sciences University/PVAMC, USA
Short Talk: Bronchial Epithelial Cells Take Up Mycobacterium tuberculosis into a Late Endosomal Compartment and Are Highly Efficient at Stimulating IFNgamma Release by CD8+ T Cells

Saturday, March 16 | 8:00AM - 11:00AM
Life and Death in Mycobacteria
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 1 of 6
* Jeffery S. Cox, University of California, Berkeley, USA


Saturday, March 16 | 8:00AM - 11:00AM
Life and Death in Mycobacteria
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 2 of 6
Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA
Mycobacterial Proteins: Here Today, Gone… Some Other Time


Saturday, March 16 | 8:00AM - 11:00AM
Life and Death in Mycobacteria
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 3 of 6
Valerie Mizrahi, University of Cape Town, South Africa
Vitain B12 Metabolism in Mycobacteria


Saturday, March 16 | 8:00AM - 11:00AM
Life and Death in Mycobacteria
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 4 of 6
Marie I. Samanovic, New York University School of Medicine, USA
Short Talk: Proteasomal Regulation of Nitric Oxide Resistance in M. tuberculosis


Saturday, March 16 | 8:00AM - 11:00AM
Life and Death in Mycobacteria
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 5 of 6
Graham F. Hatfull, University of Pittsburgh, USA
Mycobacteriophages and Mycobacterium tuberculosis


Saturday, March 16 | 8:00AM - 11:00AM
Life and Death in Mycobacteria
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 6 of 6
Kerstin Williams, University of Surrey, UK
Short Talk: Global Response of Mycobacteria to Nitrogen Stress


Saturday, March 16 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Saturday, March 16 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Saturday, March 16 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Saturday, March 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Saturday, March 16 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Saturday, March 16 | 5:00PM - 7:00PM
A Global View of Infection (Joint)
Room: Sea to Sky B/C
Unbiased techniques can highlight novel pathways and mechanisms of disease. This session will address the increased understanding of TB that these approaches have generated.
Speaker 1 of 4
* Sébastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
Evolutionary Forces in Mycobacterium tuberculosis

Saturday, March 16 | 5:00PM - 7:00PM
A Global View of Infection (Joint)
Room: Sea to Sky B/C
Unbiased techniques can highlight novel pathways and mechanisms of disease. This session will address the increased understanding of TB that these approaches have generated.
Speaker 2 of 4
Scarlet S. Shell, Worcester Polytechnic Institute, USA
Short Talk: Widespread mRNA Processing Shapes the Mycobacterium tuberculosis Transcriptome

Saturday, March 16 | 5:00PM - 7:00PM
A Global View of Infection (Joint)
Room: Sea to Sky B/C
Unbiased techniques can highlight novel pathways and mechanisms of disease. This session will address the increased understanding of TB that these approaches have generated.
Speaker 3 of 4
Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands
Short Talk: An Unbiased Genome-Wide Mycobacterium tuberculosis Gene-Expression Approach to Discover New Antigens for Human T Cells that Are Expressed during Pulmonary Infection

Saturday, March 16 | 5:00PM - 7:00PM
A Global View of Infection (Joint)
Room: Sea to Sky B/C
Unbiased techniques can highlight novel pathways and mechanisms of disease. This session will address the increased understanding of TB that these approaches have generated.
Speaker 4 of 4
Jean-Laurent Casanova, Rockefeller University, USA
Toward a Genetic Theory of Infectious Diseases

Saturday, March 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Saturday, March 16 | 7:30PM - 10:00PM
Poster Session 3
Room: Sea to Sky A


Sunday, March 17 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A, Garibaldi B/C


Sunday, March 17 | 7:30AM - 8:00AM
Poster Setup
Room: Sea to Sky A


Sunday, March 17 | 8:00AM - 5:00PM
Poster Viewing
Room: Sea to Sky A


Sunday, March 17 | 8:00AM - 11:15AM
Tuberculosis and HIV
Room: Sea to Sky B
These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.
Speaker 1 of 6
Robert J. Wilkinson, University of Cape Town, South Africa
The Heart, Mind and Breath of HIV-Associated Tuberculosis

Sunday, March 17 | 8:00AM - 11:15AM
Tuberculosis and HIV
Room: Sea to Sky B
These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.
Speaker 2 of 6
* JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Modeling HIV-TB Immune Interaction in Non-Human Primates

Sunday, March 17 | 8:00AM - 11:15AM
Tuberculosis and HIV
Room: Sea to Sky B
These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.
Speaker 3 of 6
Marcelo Kuroda, Tulane University, USA
Short Talk: Macrophage Damage by SIV as the Cause of TB Reactivation in the TB/SIV Rhesus Co-Infection Model

Sunday, March 17 | 8:00AM - 11:15AM
Tuberculosis and HIV
Room: Sea to Sky B
These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.
Speaker 4 of 6
Daniel L. Barber, NIAID, National Institutes of Health, USA
Mechanisms of Mycobacteria-Associated Immune Reconstitution Inflammatory Syndrome

Sunday, March 17 | 8:00AM - 11:15AM
Tuberculosis and HIV
Room: Sea to Sky B
These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.
Speaker 5 of 6
Richard A. Koup, NIAID, National Institutes of Health, USA
HIV-Tuberculosis Interaction

Sunday, March 17 | 8:00AM - 11:15AM
Tuberculosis and HIV
Room: Sea to Sky B
These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.
Speaker 6 of 6
Tracy R. Rosebrock, Harvard School of Public Health, USA
Short Talk: Single Cell Analysis Reveals Distinct Effects of HIV on Mycobacterium tuberculosis Survival in Co-Infected and Bystander Macrophages

Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 1 of 7
* Sarah M. Fortune, Harvard TH Chan School of Public Health, USA


Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 2 of 7
Mary Jackson, Colorado State University, USA
Cell Envelope Glycoconjugates: Metabolism and Interaction with the Host


Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 3 of 7
Keith M. Derbyshire, Wadsworth Center, New York State Department of Health, USA
ESX, its Role in Secretion, Sex and Mycobacterial Evolution


Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 4 of 7
Michael Niederweis, University of Alabama at Birmingham, USA
Iron Utilization by M. tuberculosis


Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 5 of 7
Christopher S. Ealand, University of the Witwatersrand, South Africa
Short Talk: The Role of Mycobacterial DD-Carboxypeptidases in Peptidoglycan Remodeling and Turnover


Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 6 of 7
Ellen Foot Perkowski, University of North Carolina, USA
Short Talk: Exported In vivo Technology (EXIT) to Identify Mtb Proteins Exported during Infection


Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
This session is from Mycobacterium tuberculosis
Room: Sea to Sky C

Speaker 7 of 7
Jeppe Mouritsen, Institute of Molecular Systems Biology, Switzerland
Short Talk: Direct Protein Quantification Reveals that Cholesterol Is a Carbon Source of Mycobacterium tuberculosis during Infection


Sunday, March 17 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Sunday, March 17 | 11:15AM - 12:00PM
Lunch
Room: Sea to Sky A, Garibaldi B/C


Sunday, March 17 | 12:00PM - 2:30PM
Poster Session 4
Room: Sea to Sky A


Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 1 of 7
* Andrea M. Cooper, University of Leicester, UK

Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 2 of 7
* Heran Darwin, New York University School of Medicine, USA

Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 3 of 7
Jonathan A. G. Cox, University of Birmingham, UK
Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 4 of 7
Allison J. Fay, Sloan-Kettering Institute, USA
A Nonredundant Essential Role for Mycobacterial DnaK in Native Protein Folding

Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 5 of 7
Alexandre Gouzy, ICNRS-University of Toulouse, France
A Novel Amino Acid Permease System for M. tuberculosis Nitrogen Acquisition and Host Colonization

Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 6 of 7
Ludovic P. Desvignes, New York University School of Medicine, USA
Dynamic Roles of Type I and Type II Interferons in Early Infection with Mycobacterium tuberculosis

Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 7 of 7
Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA
IL-1 Driven Eicosanoids Mediate Host Resistance to Mycobacterium tuberculosis Infection

Sunday, March 17 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Sunday, March 17 | 5:00PM - 6:45PM
Host Susceptibility to Disease (Joint)
Room: Sea to Sky B/C
What are the factors that allow disease to ?develop in some exposed individuals and not ?others?
Speaker 1 of 4
* Robert J. Wilkinson, University of Cape Town, South Africa

Sunday, March 17 | 5:00PM - 6:45PM
Host Susceptibility to Disease (Joint)
Room: Sea to Sky B/C
What are the factors that allow disease to ?develop in some exposed individuals and not ?others?
Speaker 2 of 4
Hardy Kornfeld, University of Massachusetts Medical School, USA
Diabetes and TB

Sunday, March 17 | 5:00PM - 6:45PM
Host Susceptibility to Disease (Joint)
Room: Sea to Sky B/C
What are the factors that allow disease to ?develop in some exposed individuals and not ?others?
Speaker 3 of 4
Erwin Schurr, Research Institute of the McGill University Health Centre, Canada
Host Genetic Control of Resistance to Infection with M. tuberculosis

Sunday, March 17 | 5:00PM - 6:45PM
Host Susceptibility to Disease (Joint)
Room: Sea to Sky B/C
What are the factors that allow disease to ?develop in some exposed individuals and not ?others?
Speaker 4 of 4
Helen McShane, Jenner Institute, UK
Boosting BCG with MVA85A – Clinical Trials and Efficacy Data

Sunday, March 17 | 6:45PM - 7:30PM
Special Session: Panel Discussion of Results of the Recently
Published Efficacy Trial of MVA85A Given as a Boost to BCG in South African Infants
Room: Sea to Sky B/C

Speaker 1 of 4
* Willem A. Hanekom, Bill & Melinda Gates Foundation, USA

Sunday, March 17 | 6:45PM - 7:30PM
Special Session: Panel Discussion of Results of the Recently
Published Efficacy Trial of MVA85A Given as a Boost to BCG in South African Infants
Room: Sea to Sky B/C

Speaker 2 of 4
Helen McShane, Jenner Institute, UK

Sunday, March 17 | 6:45PM - 7:30PM
Special Session: Panel Discussion of Results of the Recently
Published Efficacy Trial of MVA85A Given as a Boost to BCG in South African Infants
Room: Sea to Sky B/C

Speaker 3 of 4
Mark Hatherill, University of Cape Town, South Africa

Sunday, March 17 | 6:45PM - 7:30PM
Special Session: Panel Discussion of Results of the Recently
Published Efficacy Trial of MVA85A Given as a Boost to BCG in South African Infants
Room: Sea to Sky B/C

Speaker 4 of 4
Thomas J. Scriba, University of Cape Town, South Africa

Sunday, March 17 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Sea to Sky A


Sunday, March 17 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A


Sunday, March 17 | 8:30PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Monday, March 18 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.