Web Desc
Tuberculosis: Understanding the Enemy
joint with Host Response in Tuberculosis
Organizer(s): Eric J. Rubin, Sébastien Gagneux and Heran Darwin
Date: March 13 - 18, 2013
Location: Whistler Conference Centre, Whistler, BC, Canada
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Despite more than a century of research, tuberculosis (TB) remains one of the leading causes of death in the world. Although drug therapy is available, it remains cumbersome and difficult to administer in areas of the developing world where TB is most prevalent. Moreover, the rise of HIV and consequent marked increase in TB susceptibility and the increasing appearance of drug resistant bacterial strains has made management of infection far more difficult. New approaches to treatment and prevention could have an enormous impact on the disease. This meeting will bring together different disciplines, including microbial genomics and genetics, bacterial physiology, systems biology and drug development, to explore how Mycobacterium tuberculosis is transmitted and causes disease. In addition, the conference will be paired with a concurrent meeting that explores host responses to TB. Together, these two conferences will cover a breadth of TB biology and examine the interface between the host and pathogen. The conference will provide an opportunity for interactions among those from different fields and include many participants from disciplines that would not ordinarily participate in a meeting devoted exclusively to TB. We hope to stimulate new collaborations and introduce novel areas of biology so that the field will be positioned to tackle the many remaining challenges for combating this disease. The meeting will also provide an opportunity to develop and engage the next generation of researchers in the field by including junior and early stage investigators in the meeting format.
Global Health Travel Award Deadline: October 16 2012
Scholarship Deadline: November 13 2012
Discounted Abstract Deadline: November 13 2012
Abstract Deadline: December 11 2012
Discounted Registration Deadline: January 14 2013
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates Foundation
$2,500 - $9,999
S. Karger AG - Respiration
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
S. Karger AG - Respiration
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI104008-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, March 13 | 4:00PM - 8:00PM
Arrival and Registration
Room: Grand Foyer


Thursday, March 14 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A, Garibaldi B/C


Thursday, March 14 | 8:00AM - 11:00AM
Mycobacterium tuberculosis - From Single Cells to Systems
Room: Sea to Sky C

Speaker 1 of 6
* Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA

Thursday, March 14 | 8:00AM - 11:00AM
Mycobacterium tuberculosis - From Single Cells to Systems
Room: Sea to Sky C

Speaker 2 of 6
Heran Darwin, New York University School of Medicine, USA
Pedal to the Metal: Copper Resistance in Mycobacterium tuberculosis

Thursday, March 14 | 8:00AM - 11:00AM
Mycobacterium tuberculosis - From Single Cells to Systems
Room: Sea to Sky C

Speaker 3 of 6
Bree B. Aldridge, Tufts University, USA
Short Talk: Back to Basics: Diversity through Growth and Division in Mycobacteria

Thursday, March 14 | 8:00AM - 11:00AM
Mycobacterium tuberculosis - From Single Cells to Systems
Room: Sea to Sky C

Speaker 4 of 6
Veronique Anne Dartois, Hackensack Meridian Health, USA
Pharmacology: The Fate of TB Drugs from Plasma to Lesions and Single Cells

Thursday, March 14 | 8:00AM - 11:00AM
Mycobacterium tuberculosis - From Single Cells to Systems
Room: Sea to Sky C

Speaker 5 of 6
Johnjoe McFadden, University of Surrey, UK
Systems-Based Metabolic Analysis of Intracellular Growth of the TB bacillus

Thursday, March 14 | 8:00AM - 11:00AM
Mycobacterium tuberculosis - From Single Cells to Systems
Room: Sea to Sky C

Speaker 6 of 6
Dany J. V. Beste, University of Surrey, UK
Short Talk: 13C Isotopomer Spectral Analysis of Cholesterol Metabolism by Mycobacterium tuberculosis Growing in vitro and within Macrophages

Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
This session is from Host Response in TB
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 1 of 7
* David G. Russell, Cornell University, USA


Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
This session is from Host Response in TB
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 2 of 7
Larry S. Schlesinger, Texas Biomedical Research Institute, USA
Unique Immunoregulatory Factors in the Lung Alveolus during the Early Microbe-Host Encounter


Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
This session is from Host Response in TB
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 3 of 7
Helen A. Fletcher, London School of Hygiene and Tropical Medicine, UK
Correlates of Risk of TB Disease in Infants Vaccinated with BCG


Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
This session is from Host Response in TB
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 4 of 7
Jennifer Philips, Washington University School of Medicine, USA
EsxH ESCRTs TB to Safety by Arresting Phagosome Maturation


Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
This session is from Host Response in TB
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 5 of 7
Ishita Bhattacharya, Garvan Institute for Medical Research, Australia
Short Talk: The Splice Variant of IL-12Rbeta1: A New Player in the IL-12 Signaling Network


Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
This session is from Host Response in TB
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 6 of 7
Cliona M. Ni Cheallaigh, Trinity College Dublin, Ireland
Short Talk: My-D88 Adapter Like (Mal) Is Required for Effective Macrophage Responses to Mycobacterium tuberculosis


Thursday, March 14 | 8:00AM - 11:00AM
How Do Innate Cells Respond to Mtb (I)
This session is from Host Response in TB
Room: Sea to Sky B
How does the lung respond to infection and how do the phagocyte and bacteria interact?
Speaker 7 of 7
Alissa C. Rothchild, University of Massachusetts Amherst, USA
Short Talk: iNKT Cell Production of GM-CSF Inhibits Growth of Mycobacterium tuberculosis


Thursday, March 14 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Thursday, March 14 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Thursday, March 14 | 11:00AM - 3:00PM
On Own for Lunch and Recreation


Thursday, March 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Thursday, March 14 | 3:30PM - 4:00PM
Coffee Available
Room: Grand Foyer


Thursday, March 14 | 4:00PM - 5:00PM
Keynote Address: TB: The Continuing Challenge (Joint)
Room: Sea to Sky B/C

Speaker 1 of 2
* Andrea M. Cooper, University of Leicester, UK

Thursday, March 14 | 4:00PM - 5:00PM
Keynote Address: TB: The Continuing Challenge (Joint)
Room: Sea to Sky B/C

Speaker 2 of 2
Chris Dye, World Health Organization, Switzerland
TB: The Continuing Challenge

Thursday, March 14 | 5:00PM - 7:00PM
How do Innate Cells Respond to Mtb? (Joint)
Room: Sea to Sky B/C
Mononuclear phagocytes are recognized as the host cells for Mtb but what do they really do? Neutrophils have been largely ignored as actors in tuberculosis, what do these cells do to contribute to disease?
Speaker 1 of 3
Carl F. Nathan, Weill Cornell Medical College, USA
Can Macrophages Be Super-Activated?

Thursday, March 14 | 5:00PM - 7:00PM
How do Innate Cells Respond to Mtb? (Joint)
Room: Sea to Sky B/C
Mononuclear phagocytes are recognized as the host cells for Mtb but what do they really do? Neutrophils have been largely ignored as actors in tuberculosis, what do these cells do to contribute to disease?
Speaker 2 of 3
Anne O'Garra, Francis Crick Institute, UK
Systems Approach to Understand the Immune Response in Tuberculosis

Thursday, March 14 | 5:00PM - 7:00PM
How do Innate Cells Respond to Mtb? (Joint)
Room: Sea to Sky B/C
Mononuclear phagocytes are recognized as the host cells for Mtb but what do they really do? Neutrophils have been largely ignored as actors in tuberculosis, what do these cells do to contribute to disease?
Speaker 3 of 3
David G. Russell, Cornell University, USA
Chemical and Genetic Perturbation of the Intracellular Survival Strategies of Mycobacterium tuberculosis

Thursday, March 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Thursday, March 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A


Friday, March 15 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A, Garibaldi B/C


Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
Room: Sea to Sky C

Speaker 1 of 7
* Graham F. Hatfull, University of Pittsburgh, USA

Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
Room: Sea to Sky C

Speaker 2 of 7
Nico C. Gey van Pittius, University of Stellenbosch, South Africa
Evolution of the PE and PPE Multi-Gene Families in the Mycobacteria

Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
Room: Sea to Sky C

Speaker 3 of 7
Thomas Ioerger, Texas A&M University, USA
What Comparative Genomics of Mycobacteria can Tell Us about Drug Resistance

Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
Room: Sea to Sky C

Speaker 4 of 7
Jeffery S. Cox, University of California, Berkeley, USA
The Ubiquitin Ligase PARKIN Is Required for Autophagy and Host Resistance to Intracellular Pathogens

Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
Room: Sea to Sky C

Speaker 5 of 7
Basim R.K. Al Shammari, Imperial College London, UK
Short Talk: Infection of MMP-1 Transgenic Mice with Virulent Mycobacterium tuberculosis Causes Human-Type Lung Pathology

Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
Room: Sea to Sky C

Speaker 6 of 7
Mireia Coscolla, Swiss Tropical and Public Health Institute, Switzerland
Short Talk: Adaptive Evolution in Different Lineages of the Mycobacterium tuberculosis Complex

Friday, March 15 | 8:00AM - 11:00AM
Mycobacterial Diversity and Disease
Room: Sea to Sky C

Speaker 7 of 7
Christophe Guilhot, Centre National de la Recherche Scientifique, France
Short Talk: Do Polymorphisms in phoPR Explain the Lower Virulence for Humans of africanum and Animal Strains of the Mycobacterium tuberculosis Complex?

Friday, March 15 | 8:00AM - 11:00AM
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradig
m?
This session is from Host Response in TB

Room: Sea to Sky B
While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.
Speaker 1 of 6
Eric G. Pamer, University of Chicago, USA
Ly6Chi Monocytes and Immune Defense Against Mycobacterium tuberculosis Infection


Friday, March 15 | 8:00AM - 11:00AM
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradig
m?
This session is from Host Response in TB

Room: Sea to Sky B
While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.
Speaker 2 of 6
* Samuel M. Behar, University of Massachusetts Medical School, USA
CD8+ T Cells and Protective Immunity to Tuberculosis


Friday, March 15 | 8:00AM - 11:00AM
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradig
m?
This session is from Host Response in TB

Room: Sea to Sky B
While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.
Speaker 3 of 6
Krishna Vankayalapati, University of Texas Health Center, USA
Short Talk: A Subpopulation of CD4+CD25+Foxp3+ T-Cells Inhibits Growth of Mycobacterium tuberculosis


Friday, March 15 | 8:00AM - 11:00AM
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradig
m?
This session is from Host Response in TB

Room: Sea to Sky B
While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.
Speaker 4 of 6
Peter L. Andersen, Statens Serum Institut, Denmark
Vaccine Induced Protection Against TB


Friday, March 15 | 8:00AM - 11:00AM
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradig
m?
This session is from Host Response in TB

Room: Sea to Sky B
While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.
Speaker 5 of 6
Albanus Moguche, Seattle Biomed, USA
Short Talk: Intrinsic CXCR5 Expression Is Required to Maintain Antigen Specific CD4 T Cells during Chronic Mycobacterium tuberculosis Infection


Friday, March 15 | 8:00AM - 11:00AM
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradig
m?
This session is from Host Response in TB

Room: Sea to Sky B
While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.
Speaker 6 of 6
Shabaana A. Khader, Washington University School of Medicine, USA
Short Talk: Interleukin-17 Mediates Vaccine-Induced Immunity Against Tuberculosis


Friday, March 15 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Friday, March 15 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Friday, March 15 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Friday, March 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Friday, March 15 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Friday, March 15 | 5:00PM - 7:00PM
Vaccination Against Mtb (Joint)
Room: Sea to Sky B/C
The availability of patients in close proximity to high tech tools for analysis of immune responses has resulted in an increase in our understanding of the human response to Mtb infection.
Speaker 1 of 4
* Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands

Friday, March 15 | 5:00PM - 7:00PM
Vaccination Against Mtb (Joint)
Room: Sea to Sky B/C
The availability of patients in close proximity to high tech tools for analysis of immune responses has resulted in an increase in our understanding of the human response to Mtb infection.
Speaker 2 of 4
Alessandro Sette, La Jolla Institute for Immunology, USA
Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed Against Three Antigenic Islands and Largely Contained in a CXCR3+CCR6+ Th1 Subset

Friday, March 15 | 5:00PM - 7:00PM
Vaccination Against Mtb (Joint)
Room: Sea to Sky B/C
The availability of patients in close proximity to high tech tools for analysis of immune responses has resulted in an increase in our understanding of the human response to Mtb infection.
Speaker 3 of 4
Thomas Evans, TomegaVax, USA
Early Results of Vaccine Trials in Humans

Friday, March 15 | 5:00PM - 7:00PM
Vaccination Against Mtb (Joint)
Room: Sea to Sky B/C
The availability of patients in close proximity to high tech tools for analysis of immune responses has resulted in an increase in our understanding of the human response to Mtb infection.
Speaker 4 of 4
Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Vaccination Against Tuberculosis: Back to Basic Research or Forward with Clinical Trials?

Friday, March 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Friday, March 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Saturday, March 16 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A, Garibaldi B/C


Saturday, March 16 | 8:00AM - 11:00AM
Life and Death in Mycobacteria
Room: Sea to Sky C

Speaker 1 of 6
* Jeffery S. Cox, University of California, Berkeley, USA

Saturday, March 16 | 8:00AM - 11:00AM
Life and Death in Mycobacteria
Room: Sea to Sky C

Speaker 2 of 6
Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA
Mycobacterial Proteins: Here Today, Gone… Some Other Time

Saturday, March 16 | 8:00AM - 11:00AM
Life and Death in Mycobacteria
Room: Sea to Sky C

Speaker 3 of 6
Valerie Mizrahi, University of Cape Town, South Africa
Vitain B12 Metabolism in Mycobacteria

Saturday, March 16 | 8:00AM - 11:00AM
Life and Death in Mycobacteria
Room: Sea to Sky C

Speaker 4 of 6
Marie I. Samanovic, New York University School of Medicine, USA
Short Talk: Proteasomal Regulation of Nitric Oxide Resistance in M. tuberculosis

Saturday, March 16 | 8:00AM - 11:00AM
Life and Death in Mycobacteria
Room: Sea to Sky C

Speaker 5 of 6
Graham F. Hatfull, University of Pittsburgh, USA
Mycobacteriophages and Mycobacterium tuberculosis

Saturday, March 16 | 8:00AM - 11:00AM
Life and Death in Mycobacteria
Room: Sea to Sky C

Speaker 6 of 6
Kerstin Williams, University of Surrey, UK
Short Talk: Global Response of Mycobacteria to Nitrogen Stress

Saturday, March 16 | 8:00AM - 11:00AM
The Consequences of the Immune Response in the Lung
This session is from Host Response in TB
Room: Sea to Sky B
Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.
Speaker 1 of 6
Denise Kirschner, University of Michigan, USA
A Systems Biology Approach to Uncovering Mechanisms Governing Host-Mycobacterial Interactions during TB Infection in the Lung and Lymph Nodes


Saturday, March 16 | 8:00AM - 11:00AM
The Consequences of the Immune Response in the Lung
This session is from Host Response in TB
Room: Sea to Sky B
Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.
Speaker 2 of 6
Clifton E. Barry III, NIAID, National Institutes of Health, USA
The Dynamics of Human Tuberculosis


Saturday, March 16 | 8:00AM - 11:00AM
The Consequences of the Immune Response in the Lung
This session is from Host Response in TB
Room: Sea to Sky B
Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.
Speaker 3 of 6
Robert J. Francis, University of Surrey, UK
Short Talk: Selective ESAT6-Dependent Necrosis of Phosphatidylserine Externalised Neutrophils


Saturday, March 16 | 8:00AM - 11:00AM
The Consequences of the Immune Response in the Lung
This session is from Host Response in TB
Room: Sea to Sky B
Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.
Speaker 4 of 6
* Jon Friedland, Imperial College London, UK
Matrix Metalloproteinases in Tuberculosis


Saturday, March 16 | 8:00AM - 11:00AM
The Consequences of the Immune Response in the Lung
This session is from Host Response in TB
Room: Sea to Sky B
Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.
Speaker 5 of 6
Manuela Flórido, Centenary Institute, Australia
Short Talk: Influenza A Virus Infection Impairs Mycobacteria-Specific T Cell Responses and Mycobacterial Clearance in the Lung during Pulmonary Co-Infection


Saturday, March 16 | 8:00AM - 11:00AM
The Consequences of the Immune Response in the Lung
This session is from Host Response in TB
Room: Sea to Sky B
Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.
Speaker 6 of 6
Melanie J. Harriff, Oregon Health & Sciences University/PVAMC, USA
Short Talk: Bronchial Epithelial Cells Take Up Mycobacterium tuberculosis into a Late Endosomal Compartment and Are Highly Efficient at Stimulating IFNgamma Release by CD8+ T Cells


Saturday, March 16 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Saturday, March 16 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Saturday, March 16 | 11:00AM - 4:30PM
On Own for Lunch and Recreation


Saturday, March 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Saturday, March 16 | 2:30PM - 4:30PM
Workshop 2: Systems Biology in TB Research
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 1 of 7
* Matthias Wilmanns, European Molecular Biology Laboratory Hamburg, Germany

Saturday, March 16 | 2:30PM - 4:30PM
Workshop 2: Systems Biology in TB Research
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 2 of 7
Matthias T. Ehebauer, European Molecular Biology Laboratory, Germany
Integrating Structural Biology into Systems Biology: Unexpected Carboxylase Activities in Mycobacteria

Saturday, March 16 | 2:30PM - 4:30PM
Workshop 2: Systems Biology in TB Research
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 3 of 7
Vítor Martins dos Santos, Wageningen University, Netherlands
Systems Approaches to Uncover the Cellular Wiring of Mycobacterium tuberculosis

Saturday, March 16 | 2:30PM - 4:30PM
Workshop 2: Systems Biology in TB Research
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 4 of 7
Wei-Hua Chen, European Molecular Biology Laboratory, Germany
Transcriptome and Proteome Analyses of Mycobacterium tuberculosis

Saturday, March 16 | 2:30PM - 4:30PM
Workshop 2: Systems Biology in TB Research
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 5 of 7
Christoph Grundner, Seattle Children's Research Institute, USA
Global Profiling of ATP Binding in M. tuberculosis

Saturday, March 16 | 2:30PM - 4:30PM
Workshop 2: Systems Biology in TB Research
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 6 of 7
Kyle Minch, Intellectual Ventures, USA
A Role for Transcriptionally Silent DNA Binding in Mycobacterium tuberculosis

Saturday, March 16 | 2:30PM - 4:30PM
Workshop 2: Systems Biology in TB Research
Room: Sea to Sky B/C
Representation from European and NIH Consortia on Systems Biology of TB
Speaker 7 of 7
Andrej Trauner, Harvard School of Public Health, USA
High-Throughput Discovery of Drug Mechanism by Gene Overexpression

Saturday, March 16 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Saturday, March 16 | 5:00PM - 7:00PM
A Global View of Infection (Joint)
Room: Sea to Sky B/C
Unbiased techniques can highlight novel pathways and mechanisms of disease. This session will address the increased understanding of TB that these approaches have generated.
Speaker 1 of 4
* Sébastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
Evolutionary Forces in Mycobacterium tuberculosis

Saturday, March 16 | 5:00PM - 7:00PM
A Global View of Infection (Joint)
Room: Sea to Sky B/C
Unbiased techniques can highlight novel pathways and mechanisms of disease. This session will address the increased understanding of TB that these approaches have generated.
Speaker 2 of 4
Scarlet S. Shell, Worcester Polytechnic Institute, USA
Short Talk: Widespread mRNA Processing Shapes the Mycobacterium tuberculosis Transcriptome

Saturday, March 16 | 5:00PM - 7:00PM
A Global View of Infection (Joint)
Room: Sea to Sky B/C
Unbiased techniques can highlight novel pathways and mechanisms of disease. This session will address the increased understanding of TB that these approaches have generated.
Speaker 3 of 4
Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands
Short Talk: An Unbiased Genome-Wide Mycobacterium tuberculosis Gene-Expression Approach to Discover New Antigens for Human T Cells that Are Expressed during Pulmonary Infection

Saturday, March 16 | 5:00PM - 7:00PM
A Global View of Infection (Joint)
Room: Sea to Sky B/C
Unbiased techniques can highlight novel pathways and mechanisms of disease. This session will address the increased understanding of TB that these approaches have generated.
Speaker 4 of 4
Jean-Laurent Casanova, Rockefeller University, USA
Toward a Genetic Theory of Infectious Diseases

Saturday, March 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Saturday, March 16 | 7:30PM - 10:00PM
Poster Session 3
Room: Sea to Sky A


Sunday, March 17 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A, Garibaldi B/C


Sunday, March 17 | 7:30AM - 8:00AM
Poster Setup
Room: Sea to Sky A


Sunday, March 17 | 8:00AM - 5:00PM
Poster Viewing
Room: Sea to Sky A


Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
Room: Sea to Sky C

Speaker 1 of 7
* Sarah M. Fortune, Harvard TH Chan School of Public Health, USA

Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
Room: Sea to Sky C

Speaker 2 of 7
Mary Jackson, Colorado State University, USA
Cell Envelope Glycoconjugates: Metabolism and Interaction with the Host

Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
Room: Sea to Sky C

Speaker 3 of 7
Keith M. Derbyshire, Wadsworth Center, New York State Department of Health, USA
ESX, its Role in Secretion, Sex and Mycobacterial Evolution

Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
Room: Sea to Sky C

Speaker 4 of 7
Michael Niederweis, University of Alabama at Birmingham, USA
Iron Utilization by M. tuberculosis

Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
Room: Sea to Sky C

Speaker 5 of 7
Christopher S. Ealand, University of the Witwatersrand, South Africa
Short Talk: The Role of Mycobacterial DD-Carboxypeptidases in Peptidoglycan Remodeling and Turnover

Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
Room: Sea to Sky C

Speaker 6 of 7
Ellen Foot Perkowski, University of North Carolina, USA
Short Talk: Exported In vivo Technology (EXIT) to Identify Mtb Proteins Exported during Infection

Sunday, March 17 | 8:00AM - 11:00AM
The Bacterial Surface and its Interaction with the Host
Room: Sea to Sky C

Speaker 7 of 7
Jeppe Mouritsen, Institute of Molecular Systems Biology, Switzerland
Short Talk: Direct Protein Quantification Reveals that Cholesterol Is a Carbon Source of Mycobacterium tuberculosis during Infection

Sunday, March 17 | 8:00AM - 11:15AM
Tuberculosis and HIV
This session is from Host Response in TB
Room: Sea to Sky B
These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.
Speaker 1 of 6
Robert J. Wilkinson, University of Cape Town, South Africa
The Heart, Mind and Breath of HIV-Associated Tuberculosis


Sunday, March 17 | 8:00AM - 11:15AM
Tuberculosis and HIV
This session is from Host Response in TB
Room: Sea to Sky B
These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.
Speaker 2 of 6
* JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Modeling HIV-TB Immune Interaction in Non-Human Primates


Sunday, March 17 | 8:00AM - 11:15AM
Tuberculosis and HIV
This session is from Host Response in TB
Room: Sea to Sky B
These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.
Speaker 3 of 6
Marcelo Kuroda, Tulane University, USA
Short Talk: Macrophage Damage by SIV as the Cause of TB Reactivation in the TB/SIV Rhesus Co-Infection Model


Sunday, March 17 | 8:00AM - 11:15AM
Tuberculosis and HIV
This session is from Host Response in TB
Room: Sea to Sky B
These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.
Speaker 4 of 6
Daniel L. Barber, NIAID, National Institutes of Health, USA
Mechanisms of Mycobacteria-Associated Immune Reconstitution Inflammatory Syndrome


Sunday, March 17 | 8:00AM - 11:15AM
Tuberculosis and HIV
This session is from Host Response in TB
Room: Sea to Sky B
These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.
Speaker 5 of 6
Richard A. Koup, NIAID, National Institutes of Health, USA
HIV-Tuberculosis Interaction


Sunday, March 17 | 8:00AM - 11:15AM
Tuberculosis and HIV
This session is from Host Response in TB
Room: Sea to Sky B
These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.
Speaker 6 of 6
Tracy R. Rosebrock, Harvard School of Public Health, USA
Short Talk: Single Cell Analysis Reveals Distinct Effects of HIV on Mycobacterium tuberculosis Survival in Co-Infected and Bystander Macrophages


Sunday, March 17 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Sunday, March 17 | 11:00AM - 12:00PM
Lunch
Room: Sea to Sky A, Garibaldi B/C


Sunday, March 17 | 12:00PM - 2:30PM
Poster Session 4
Room: Sea to Sky A


Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C

Speaker 1 of 7
* Andrea M. Cooper, University of Leicester, UK

Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C

Speaker 2 of 7
* Heran Darwin, New York University School of Medicine, USA

Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C

Speaker 3 of 7
Jonathan A. G. Cox, University of Birmingham, UK
Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C

Speaker 4 of 7
Allison J. Fay, Sloan-Kettering Institute, USA
A Nonredundant Essential Role for Mycobacterial DnaK in Native Protein Folding

Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C

Speaker 5 of 7
Alexandre Gouzy, ICNRS-University of Toulouse, France
A Novel Amino Acid Permease System for M. tuberculosis Nitrogen Acquisition and Host Colonization

Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C

Speaker 6 of 7
Ludovic P. Desvignes, New York University School of Medicine, USA
Dynamic Roles of Type I and Type II Interferons in Early Infection with Mycobacterium tuberculosis

Sunday, March 17 | 2:30PM - 4:30PM
Workshop 3: Joint Workshop (Joint)
Room: Sea to Sky B/C

Speaker 7 of 7
Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA
IL-1 Driven Eicosanoids Mediate Host Resistance to Mycobacterium tuberculosis Infection

Sunday, March 17 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Sunday, March 17 | 5:00PM - 6:45PM
Host Susceptibility to Disease (Joint)
Room: Sea to Sky B/C
What are the factors that allow disease to develop in some exposed individuals and not others?
Speaker 1 of 4
* Robert J. Wilkinson, University of Cape Town, South Africa

Sunday, March 17 | 5:00PM - 6:45PM
Host Susceptibility to Disease (Joint)
Room: Sea to Sky B/C
What are the factors that allow disease to develop in some exposed individuals and not others?
Speaker 2 of 4
Hardy Kornfeld, University of Massachusetts Medical School, USA
Diabetes and TB

Sunday, March 17 | 5:00PM - 6:45PM
Host Susceptibility to Disease (Joint)
Room: Sea to Sky B/C
What are the factors that allow disease to develop in some exposed individuals and not others?
Speaker 3 of 4
Erwin Schurr, Research Institute of the McGill University Health Centre, Canada
Host Genetic Control of Resistance to Infection with M. tuberculosis

Sunday, March 17 | 5:00PM - 6:45PM
Host Susceptibility to Disease (Joint)
Room: Sea to Sky B/C
What are the factors that allow disease to develop in some exposed individuals and not others?
Speaker 4 of 4
Helen McShane, Jenner Institute, UK
Boosting BCG with MVA85A – Clinical Trials and Efficacy Data

Sunday, March 17 | 6:45PM - 7:30PM
Special Session: Panel Discussion of Results of the Recently
Published Efficacy Trial of MVA85A Given as a Boost to BCG in South African Infants
Room: Sea to Sky B/C

Speaker 1 of 4
* Willem A. Hanekom, Bill & Melinda Gates Foundation, USA

Sunday, March 17 | 6:45PM - 7:30PM
Special Session: Panel Discussion of Results of the Recently
Published Efficacy Trial of MVA85A Given as a Boost to BCG in South African Infants
Room: Sea to Sky B/C

Speaker 2 of 4
Helen McShane, Jenner Institute, UK

Sunday, March 17 | 6:45PM - 7:30PM
Special Session: Panel Discussion of Results of the Recently
Published Efficacy Trial of MVA85A Given as a Boost to BCG in South African Infants
Room: Sea to Sky B/C

Speaker 3 of 4
Mark Hatherill, University of Cape Town, South Africa

Sunday, March 17 | 6:45PM - 7:30PM
Special Session: Panel Discussion of Results of the Recently
Published Efficacy Trial of MVA85A Given as a Boost to BCG in South African Infants
Room: Sea to Sky B/C

Speaker 4 of 4
Thomas J. Scriba, University of Cape Town, South Africa

Sunday, March 17 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Sea to Sky A


Sunday, March 17 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A


Sunday, March 17 | 8:30PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Monday, March 18 | 10:25AM - 10:25AM
Departure


*Session Chair.