Web Desc
Advances in the Knowledge and Treatment of Autoimmunity
joint with Immunopathology of Type 1 Diabetes
Organizer(s): Juan Rivera, Virginia Pascual and David M. Lee
Date: April 04 - 09, 2013
Location: Fairmont Chateau Whistler, Whistler, BC, Canada
Sponsored by Biogen Idec, MedImmune and Novo Nordisk A/S
Summary of Meeting:
Understanding the mechanisms by which tolerance is induced and circumvented is important for the development of new therapies for autoimmune disorders. While significant progress has been made in understanding the basic processes of both central and peripheral tolerance, the integration of these mechanisms in the context of the pathogenesis of autoimmunity is still in its infancy. In the past few years, considerable effort has been made in bringing together the fundamental mechanisms, the genetics and genomics, the cellular players, and the clinical features of disease towards developing novel therapeutic strategies. These efforts have also advanced our understanding of the pathogenesis of autoimmunity and revealed new players and potential therapeutic strategies in treatment of autoimmunity. The goal of this Keystone Symposia meeting on Advances in the Knowledge and Treatment of Autoimmunity is to bring together scientists and clinicians to discuss what we are learning from the information obtained from mouse models, patient studies and the use of novel targeted therapies. Both common and unique immune-mediated mechanisms leading to autoimmune diseases will be highlighted. The meeting will cover advances in genomic and cellular approaches, biomarker discovery, and in targeted therapies. The accompanying workshops will be designed to promote interactions and collaborations between academic and R & D scientists to respond to the challenges in this area. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Immunopathology of Type 1 Diabetes, which will share a keynote session and two plenary sessions with this meeting.
Scholarship Deadline: December 4 2012
Discounted Abstract Deadline: December 4 2012
Abstract Deadline: January 4 2013
Discounted Registration Deadline: February 4 2013
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Biogen IdecMedImmuneNovo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
Opsona Therapeutics Ltd
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

ImmusanT, Inc.

Novartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI106184-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, April 04 | 3:00PM - 7:30PM
Arrival and Registration
Room: MacDonald Foyer


Thursday, April 04 | 6:15PM - 7:15PM
Refreshments
Room: MacDonald Foyer


Thursday, April 04 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: MacDonald ABC

Speaker 5 of 5
Diane Mathis, Harvard Medical School, USA
Anti-Inflammatory Macrophages
Regulate the Progression of T1D


Thursday, April 04 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: MacDonald ABC

Speaker 4 of 5
* Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA

Thursday, April 04 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: MacDonald ABC

Speaker 3 of 5
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Innate Immunity, Autoinflammation and Autoimmunity

Thursday, April 04 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: MacDonald ABC

Speaker 2 of 5
* Juan Rivera, USA

Thursday, April 04 | 7:15PM - 9:30PM
Welcome and Keynote Session (Joint)
Room: MacDonald ABC

Speaker 1 of 5
* Kevan C. Herold, Yale University, USA
Welcome Remarks

Friday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac Ballrm and Foyer


Friday, April 05 | 8:00AM - 11:30AM
Modulation of Immunity toward Autoimmune Therapy: From Mouse
to Man (Joint)

Room: MacDonald ABC
The focus of this session is on the regulatory networks controlling immune response and the modulation of these processes towards amelioration of autoimmune disease.
Speaker 7 of 7
Maria Grazia Roncarolo, Stanford University School of Medicine, USA
Adaptive Immune Therapy with Regulatory T Cells for the Treatment of Autoimmunity

Friday, April 05 | 8:00AM - 11:30AM
Modulation of Immunity toward Autoimmune Therapy: From Mouse
to Man (Joint)

Room: MacDonald ABC
The focus of this session is on the regulatory networks controlling immune response and the modulation of these processes towards amelioration of autoimmune disease.
Speaker 6 of 7
Stephen D. Miller, Northwestern University Medical School, USA
Induction of Immune Tolerance in the Treatment of Autoimmunity

Friday, April 05 | 8:00AM - 11:30AM
Modulation of Immunity toward Autoimmune Therapy: From Mouse
to Man (Joint)

Room: MacDonald ABC
The focus of this session is on the regulatory networks controlling immune response and the modulation of these processes towards amelioration of autoimmune disease.
Speaker 5 of 7
Jon D. Piganelli, University of Pittsburgh, Children's Hospital, USA
Short Talk: Modulating the Bioenergetics of a Diabetogenic Immune Response

Friday, April 05 | 8:00AM - 11:30AM
Modulation of Immunity toward Autoimmune Therapy: From Mouse
to Man (Joint)

Room: MacDonald ABC
The focus of this session is on the regulatory networks controlling immune response and the modulation of these processes towards amelioration of autoimmune disease.
Speaker 4 of 7
Alexander V. Chervonsky, University of Chicago, USA
Microbial Influence on Type 1 Diabetes

Friday, April 05 | 8:00AM - 11:30AM
Modulation of Immunity toward Autoimmune Therapy: From Mouse
to Man (Joint)

Room: MacDonald ABC
The focus of this session is on the regulatory networks controlling immune response and the modulation of these processes towards amelioration of autoimmune disease.
Speaker 3 of 7
Arlene H. Sharpe, Harvard Medical School, USA
Control of Humoral Immunity by Lymph Node and Blood T Follicular Regulatory Cells

Friday, April 05 | 8:00AM - 11:30AM
Modulation of Immunity toward Autoimmune Therapy: From Mouse
to Man (Joint)

Room: MacDonald ABC
The focus of this session is on the regulatory networks controlling immune response and the modulation of these processes towards amelioration of autoimmune disease.
Speaker 2 of 7
Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
Molecular Control of Treg Stability and Function

Friday, April 05 | 8:00AM - 11:30AM
Modulation of Immunity toward Autoimmune Therapy: From Mouse
to Man (Joint)

Room: MacDonald ABC
The focus of this session is on the regulatory networks controlling immune response and the modulation of these processes towards amelioration of autoimmune disease.
Speaker 1 of 7
* Pere Santamaria, University of Calgary, Canada

Friday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: MacDonald Foyer


Friday, April 05 | 11:30AM - 4:30PM
On Own for Lunch and Recreation


Friday, April 05 | 11:30AM - 1:00PM
Poster Setup
Room: Frontenac Ballrm and Foyer


Friday, April 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Frontenac Ballrm and Foyer


Friday, April 05 | 4:30PM - 5:00PM
Coffee Available
Room: MacDonald Foyer


Friday, April 05 | 5:00PM - 7:00PM
Mechanisms of Peripheral and Central Tolerance
Room: MacDonald CD

Speaker 2 of 4
* Kristin V. Tarbell, Amgen, USA
Diabetes, Dendritic Cells, and Induction of T Cell Tolerance

Friday, April 05 | 5:00PM - 7:00PM
Mechanisms of Peripheral and Central Tolerance
Room: MacDonald CD

Speaker 1 of 4
John W. Kappler, HHMI/National Jewish Health, USA
Defining the Structural Nature of the Pathogenic CD4 T cell Ligands in NOD Type 1 Diabetes

Friday, April 05 | 5:00PM - 7:00PM
Mechanisms of Peripheral and Central Tolerance
Room: MacDonald CD

Speaker 3 of 4
Shannon J. Turley, Genentech, Inc., USA
Interactions of DCs and T Cells with Lymphoid Stroma

Friday, April 05 | 5:00PM - 7:00PM
Mechanisms of Peripheral and Central Tolerance
Room: MacDonald CD

Speaker 4 of 4
Brian D. Stadinski, University of Massachusetts Medical School, USA
Short Talk: TCRalpha to TCRbeta Interactions Control Peptide Specificity and Self-Tolerance

Friday, April 05 | 5:00PM - 7:00PM
Immune Effector/Autoantigens in T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 1 of 5
* Bart O. Roep, Leiden University Medical Center, Netherlands


Friday, April 05 | 5:00PM - 7:00PM
Immune Effector/Autoantigens in T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 2 of 5
Emil R. Unanue, Washington University School of Medicine, USA
Identifying Early Cellular and Genetic Events in NOD Diabetogenesis


Friday, April 05 | 5:00PM - 7:00PM
Immune Effector/Autoantigens in T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 3 of 5
Teresa P. DiLorenzo, Albert Einstein College of Medicine, USA
Antigen-Specific T Cells in NOD Mouse Models of Diabetes


Friday, April 05 | 5:00PM - 7:00PM
Immune Effector/Autoantigens in T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 4 of 5
Rachel S. Friedman, National Jewish Health and University of Colorado Denver, USA
Short Talk: T Cell Restimulation through Synaptic Contacts at the Autoimmune Disease Site Drives Effector Cytokine Production


Friday, April 05 | 5:00PM - 7:00PM
Immune Effector/Autoantigens in T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 5 of 5
Mark Peakman, King's College London, UK
Pathogenic T Cells in Human T1D


Friday, April 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Frontenac Ballrm and Foyer


Friday, April 05 | 7:30PM - 10:00PM
Poster Session 1
Room: Frontenac Ballrm and Foyer


Saturday, April 06 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac Ballrm and Foyer


Saturday, April 06 | 8:00AM - 11:15AM
Innate Immunity and Autoimmune Disease
Room: MacDonald CD
Explores how innate immune cells play a role in the initiaition and progression of autoimmunity.
Speaker 1 of 6
* Silvia Bolland, NIAID, National Institutes of Health, USA
TLR7-Induced NK Innate Lymphoid Cells

Saturday, April 06 | 8:00AM - 11:15AM
Innate Immunity and Autoimmune Disease
Room: MacDonald CD
Explores how innate immune cells play a role in the initiaition and progression of autoimmunity.
Speaker 2 of 6
Virginia Pascual, Cornell University, USA
Novel Myeloid Cell B Helper Pathways in SLE

Saturday, April 06 | 8:00AM - 11:15AM
Innate Immunity and Autoimmune Disease
Room: MacDonald CD
Explores how innate immune cells play a role in the initiaition and progression of autoimmunity.
Speaker 3 of 6
Juan Rivera, USA
Auto-Reactive IgE and Basophils in the Amplification of SLE

Saturday, April 06 | 8:00AM - 11:15AM
Innate Immunity and Autoimmune Disease
Room: MacDonald CD
Explores how innate immune cells play a role in the initiaition and progression of autoimmunity.
Speaker 4 of 6
Melissa A. Brown, Northwestern University, USA
Mast Cells in the Meninges: Orchestrators of Early Inflammation in CNS Disease

Saturday, April 06 | 8:00AM - 11:15AM
Innate Immunity and Autoimmune Disease
Room: MacDonald CD
Explores how innate immune cells play a role in the initiaition and progression of autoimmunity.
Speaker 5 of 6
Roland W. Kolbeck, MedImmune, LLC, USA
Short Talk: LC3 Associated Phagocytosis Mediates IFNalpha Secretion in Response to DNA-Immune Complexes

Saturday, April 06 | 8:00AM - 11:15AM
Innate Immunity and Autoimmune Disease
Room: MacDonald CD
Explores how innate immune cells play a role in the initiaition and progression of autoimmunity.
Speaker 6 of 6
Carla M. Cuda, Northwestern University, USA
Short Talk: Caspase 8 Limits Dendritic Cell Activation

Saturday, April 06 | 8:00AM - 11:30AM
Regulatory and Developmental Control of T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 1 of 7
* Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA


Saturday, April 06 | 8:00AM - 11:30AM
Regulatory and Developmental Control of T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 2 of 7
Mark S. Anderson, University of California, San Francisco, USA
Immune Tolerance Mediated by Extrathymic Aire


Saturday, April 06 | 8:00AM - 11:30AM
Regulatory and Developmental Control of T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 3 of 7
Stephan Kissler, Joslin Diabetes Center, USA
Short Talk: The Type 1 Diabetes-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Function and Impacts Central Tolerance


Saturday, April 06 | 8:00AM - 11:30AM
Regulatory and Developmental Control of T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 4 of 7
Jeffrey A. Bluestone, University of California, San Francisco, USA
Regulatory T Cells: Controlling Your (Immune) Temper


Saturday, April 06 | 8:00AM - 11:30AM
Regulatory and Developmental Control of T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 5 of 7
Pere Santamaria, University of Calgary, Canada
Maturation and Modulation of CD8+ T Effector Cells


Saturday, April 06 | 8:00AM - 11:30AM
Regulatory and Developmental Control of T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 6 of 7
Jane H. Buckner, Benaroya Research Institute at Virginia Mason, USA
T Cell Deregulation in Human T1DM


Saturday, April 06 | 8:00AM - 11:30AM
Regulatory and Developmental Control of T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 7 of 7
David A. Hafler, Yale University School of Medicine, USA
Common Non-Coding Variation at Enhancers Reveals Multi-lineage Contribution to Human Autoimmune Disease


Saturday, April 06 | 9:20AM - 9:40AM
Coffee Break
Room: MacDonald Foyer


Saturday, April 06 | 11:15AM - 1:00PM
Poster Setup
Room: Frontenac Ballrm and Foyer


Saturday, April 06 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Saturday, April 06 | 11:30AM - 12:30PM
NIDDK Workshop: When is a Mechanism not a Mechanism? NIH Adv
ice for Young Investigators
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 1 of 1
* Lisa Spain, NIDDK, National Institute of Health, USA


Saturday, April 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Frontenac Ballrm and Foyer


Saturday, April 06 | 4:30PM - 5:00PM
Coffee Available
Room: MacDonald Foyer


Saturday, April 06 | 5:00PM - 7:00PM
Challenges and Lessons from Immunotherapy
Room: MacDonald CD
This session explores how identification of biomarkers and new treatments are advancing our knowledge of mechanisms and the pathophysiology underlying autoimmune disease and explores the challenges faced in the development and use of therapies in autoimmunity
Speaker 1 of 4
* Timothy W. Behrens, Genentech, Inc., USA
Personalizing Medicine for Autoimmune and Inflammatory Diseases

Saturday, April 06 | 5:00PM - 7:00PM
Challenges and Lessons from Immunotherapy
Room: MacDonald CD
This session explores how identification of biomarkers and new treatments are advancing our knowledge of mechanisms and the pathophysiology underlying autoimmune disease and explores the challenges faced in the development and use of therapies in autoimmunity
Speaker 2 of 4
Atul J. Butte, University of California, San Francisco, USA
Transforming 300 Billion Points of Data into Diagnostics, Therapeutics, and New Insights into Immunological Disease

Saturday, April 06 | 5:00PM - 7:00PM
Challenges and Lessons from Immunotherapy
Room: MacDonald CD
This session explores how identification of biomarkers and new treatments are advancing our knowledge of mechanisms and the pathophysiology underlying autoimmune disease and explores the challenges faced in the development and use of therapies in autoimmunity
Speaker 3 of 4
Robert P. Anderson, ImmusanT, Inc., USA
Celiac Disease - Can We Transition from Peptides to Treatment?

Saturday, April 06 | 5:00PM - 7:00PM
Challenges and Lessons from Immunotherapy
Room: MacDonald CD
This session explores how identification of biomarkers and new treatments are advancing our knowledge of mechanisms and the pathophysiology underlying autoimmune disease and explores the challenges faced in the development and use of therapies in autoimmunity
Speaker 4 of 4
Steve D. Levin, Alpine Immune Sciences, USA
Short Talk: IL21 Contributes to Human Autoimmune Disease through Multiple Mechanisms and IL21 Neutralization has Beneficial Effects in vitro

Saturday, April 06 | 5:00PM - 7:00PM
Workshop 1: Basic Research Advances
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 1 of 9
* Anne Cooke, University of Cambridge, UK


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 1: Basic Research Advances
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 2 of 9
Imran S. Khan, University of California, San Francisco, USA
MicroRNA Regulation of Thymic Epithelial Cell Biology and Central Tolerance


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 1: Basic Research Advances
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 3 of 9
Yong Fan, University of Pittsburgh, Children's Hospital of Pittsburgh, USA
ID-TEC and ID-TEC-Rag Mice, Novel Animal Models for Studying Insulin Autoimmunity in Type 1 Diabetes


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 1: Basic Research Advances
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 4 of 9
Maria Bettini, Baylor College of Medicine, USA
TCR Affinity Shapes T Cell Pathogenicity and Susceptibility to Tolerance Mechanisms


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 1: Basic Research Advances
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 5 of 9
Allyson M. Spence, University of California, San Francisco, USA
Regulatory T Cell Commitment and Destabilization in the Inflamed Islets of NOD Mice


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 1: Basic Research Advances
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 6 of 9
Lindsey E. Padgett, University of Alabama, Birmingham, USA
Reactive Oxygen Species Modulate CD4 T Cell Effector Responses in T1D


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 1: Basic Research Advances
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 7 of 9
Karmel Allison, University of California, San Diego, USA
Genome-Wide Sequencing of Nascent Transcripts in NOD Mouse Macrophages Reveals New Mechanisms of Innate Immune Disregulation in Type 1 Diabetes


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 1: Basic Research Advances
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 8 of 9
Rochelle M. Hinman, National Jewish Health, USA
Function and Fate of Insulin Reactive B Cells in Type 1 Diabetes


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 1: Basic Research Advances
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 9 of 9
Eliana Marino, Monash University, Australia
A Strong Gut Feeling about the Cause of Type 1 Diabetes


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 2: Translational/Clinical Research Advances
This session is from Type 1 Diabetes
Room: MacDonald EF

Speaker 1 of 9
* Kevan C. Herold, Yale University, USA


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 2: Translational/Clinical Research Advances
This session is from Type 1 Diabetes
Room: MacDonald EF

Speaker 2 of 9
Matthew M. Rankin, Janssen Pharmaceutical, USA
Increased Islet Replication and Persistent Insulitis in Pancreata from Adolescent T1D Patients


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 2: Translational/Clinical Research Advances
This session is from Type 1 Diabetes
Room: MacDonald EF

Speaker 3 of 9
Gaetano Faleo, University of California, San Francisco, USA
Protection of Allogeneic Cells from Alloimmune-Mediated Rejection Using Macroencapsulation


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 2: Translational/Clinical Research Advances
This session is from Type 1 Diabetes
Room: MacDonald EF

Speaker 4 of 9
Melanie Stumpf, University of Colorado Denver, USA
Identification of Disease-Associated TCR alpha and beta Chains Directly from Pancreas Tissue of T1D Patients


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 2: Translational/Clinical Research Advances
This session is from Type 1 Diabetes
Room: MacDonald EF

Speaker 5 of 9
Nalini K. Vudattu, Yale University, USA
The Study of Autoimmune Disease in Humanized Mice


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 2: Translational/Clinical Research Advances
This session is from Type 1 Diabetes
Room: MacDonald EF

Speaker 6 of 9
Rachel H. Bonami, Vanderbilt University, USA
Autoantigen-Targeted Therapy: Stopping Anti-Insulin B Cells from Giving T Cells Bad Advice


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 2: Translational/Clinical Research Advances
This session is from Type 1 Diabetes
Room: MacDonald EF

Speaker 7 of 9
Brian T. Fife, University of Minnesota, USA
Indirect Presentation of Antigen-Coupled Cells Mediates Specific CD4+ T Cell Tolerance for the Prevention of T1D


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 2: Translational/Clinical Research Advances
This session is from Type 1 Diabetes
Room: MacDonald EF

Speaker 8 of 9
Sofie Robert, KU Leuven, Belgium
Islet Autoantigens Delivered by L. lactis in the Gut Together with hIL-10 Revert Diabetes in Recent-Onset NOD Mice when Combined with Low-Dose Anti-CD3


Saturday, April 06 | 5:00PM - 7:00PM
Workshop 2: Translational/Clinical Research Advances
This session is from Type 1 Diabetes
Room: MacDonald EF

Speaker 9 of 9
Michael D. McHugh, Yale University, USA
Induction of Tolerance in Type 1 Diabetes Using Biodegradable Nanoparticles


Saturday, April 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Frontenac Ballrm and Foyer


Saturday, April 06 | 7:30PM - 10:00PM
Poster Session 2
Room: Frontenac Ballrm and Foyer


Sunday, April 07 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac Ballrm and Foyer


Sunday, April 07 | 8:00AM - 11:15AM
The Microflora in the Regulation of Immunity and Autoimmunit
y (Joint)

Room: MacDonald ABC
Reviews recent advance on the microbiomes influence in initiation, progression, and regulation of immune responses and autoimmune disease.
Speaker 1 of 6
George M. Weinstock, The Jackson Laboratory, USA
Overview of the Human Microbiome: A New Frontier that just Might Affect Everything

Sunday, April 07 | 8:00AM - 11:15AM
The Microflora in the Regulation of Immunity and Autoimmunit
y (Joint)

Room: MacDonald ABC
Reviews recent advance on the microbiomes influence in initiation, progression, and regulation of immune responses and autoimmune disease.
Speaker 2 of 6
* Jayne S. Danska, Hospital for Sick Children Research Institute, Canada
The Gut Microbiome Drives Hormone-Dependent Regulation of Type 1 Diabetes

Sunday, April 07 | 8:00AM - 11:15AM
The Microflora in the Regulation of Immunity and Autoimmunit
y (Joint)

Room: MacDonald ABC
Reviews recent advance on the microbiomes influence in initiation, progression, and regulation of immune responses and autoimmune disease.
Speaker 3 of 6
Fiona M. Powrie, University of Oxford, UK
Microbiome-Induced IL-23 Promotes Intestinal Inflammation and Colon Cancer

Sunday, April 07 | 8:00AM - 11:15AM
The Microflora in the Regulation of Immunity and Autoimmunit
y (Joint)

Room: MacDonald ABC
Reviews recent advance on the microbiomes influence in initiation, progression, and regulation of immune responses and autoimmune disease.
Speaker 4 of 6
Mark A. Atkinson, University of Florida, USA
The Role for the Gut Microbiome in Type 1 Diabetes – Early Lessons from Humans and NOD Mice

Sunday, April 07 | 8:00AM - 11:15AM
The Microflora in the Regulation of Immunity and Autoimmunit
y (Joint)

Room: MacDonald ABC
Reviews recent advance on the microbiomes influence in initiation, progression, and regulation of immune responses and autoimmune disease.
Speaker 5 of 6
Joseph Larkin III, University of Florida, USA
Short Talk: Antigen Presenting Cell Interactions with Gut Flora Modulate Diabetogenic T Lymphocyte Effector Functions

Sunday, April 07 | 8:00AM - 11:15AM
The Microflora in the Regulation of Immunity and Autoimmunit
y (Joint)

Room: MacDonald ABC
Reviews recent advance on the microbiomes influence in initiation, progression, and regulation of immune responses and autoimmune disease.
Speaker 6 of 6
Lloyd H. Kasper, Geisel School of Medicine at Dartmouth, USA
Role of Commensal Bacteria in the Regulation of Central Nervous System Disease Demyelination

Sunday, April 07 | 9:20AM - 9:40AM
Coffee Break
Room: MacDonald Foyer


Sunday, April 07 | 11:00AM - 1:00PM
Poster Setup
Room: Frontenac Ballrm and Foyer


Sunday, April 07 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Sunday, April 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Frontenac Ballrm and Foyer


Sunday, April 07 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms in Autoimmunity
Room: MacDonald AB

Speaker 1 of 7
* Shannon J. Turley, Genentech, Inc., USA

Sunday, April 07 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms in Autoimmunity
Room: MacDonald AB

Speaker 2 of 7
Rachel R. Caspi, NEI, National Institutes of Health, USA
IL-27p28 Inhibits CNS Autoimmunity by Concurrently Antagonizing Th1 and Th17 Responses

Sunday, April 07 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms in Autoimmunity
Room: MacDonald AB

Speaker 3 of 7
Tian Chi, Yale University, USA
BRG1-Mediated Immune Tolerance:
Facilitation of Treg Activation and Partial Independence of Chromatin Remodeling


Sunday, April 07 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms in Autoimmunity
Room: MacDonald AB

Speaker 4 of 7
Benoit L. Salomon, University Pierre et Marie Curie, France
TNFalpha /TNFR2 Pathway Is Critical for EAE Remission and Treg Expansion in the Central Nervous System

Sunday, April 07 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms in Autoimmunity
Room: MacDonald AB

Speaker 5 of 7
Jianmei W. Leavenworth, Dana-Farber Cancer Institute, USA
Amelioration of Arthritis through Mobilization of Peptide-Specific CD8+ Regulatory T-Cells

Sunday, April 07 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms in Autoimmunity
Room: MacDonald AB

Speaker 6 of 7
Natalia V. Giltiay, Washington University, USA
Antigen Delivery to pDCs through hBDCA2 Leads to Reduction of Effector T-Cell Activation and Ag-Specific Ab Responses

Sunday, April 07 | 2:30PM - 4:30PM
Workshop 1: Basic Mechanisms in Autoimmunity
Room: MacDonald AB

Speaker 7 of 7
Rajat Varma, Xencor Inc., USA
T Cell Receptor Microclusters are Platforms for Ligand Discrimination

Sunday, April 07 | 2:30PM - 4:30PM
Workshop 2: Clinical and Translational Aspects of Autoimmuni
ty
Room: MacDonald CD

Speaker 1 of 7
* Jane H. Buckner, Benaroya Research Institute at Virginia Mason, USA

Sunday, April 07 | 2:30PM - 4:30PM
Workshop 2: Clinical and Translational Aspects of Autoimmuni
ty
Room: MacDonald CD

Speaker 2 of 7
Simone Caielli, Baylor Institute for Immunology Research, USA
SLE Neutrophil-Derived DAMPs Activate pDCs to Induce a Lupus-Specific CD4 T Cell Phenotype

Sunday, April 07 | 2:30PM - 4:30PM
Workshop 2: Clinical and Translational Aspects of Autoimmuni
ty
Room: MacDonald CD

Speaker 3 of 7
Barbara Dema, NIAMS, National Institutes of Health, USA
Prevalence of Auto-Reactive IgE and Activated Basophils in Systemic Lupus Erythematosus

Sunday, April 07 | 2:30PM - 4:30PM
Workshop 2: Clinical and Translational Aspects of Autoimmuni
ty
Room: MacDonald CD

Speaker 4 of 7
Gabriela Hernandez-Hoyos, Emergent BioSolutions, USA
A Bi-Specific ADAPTIR Molecule that Targets CD86 and Delivers IL-10 Inhibits Antigen Presenting Cells and Has Potential as a Therapeutic Treatment of Autoimmune Disease

Sunday, April 07 | 2:30PM - 4:30PM
Workshop 2: Clinical and Translational Aspects of Autoimmuni
ty
Room: MacDonald CD

Speaker 5 of 7
Silvia Preite, National Institutes of Health, USA
Regulation of T Helper Cell-Dependent Antibody Response in Lymphopenic Hosts

Sunday, April 07 | 2:30PM - 4:30PM
Workshop 2: Clinical and Translational Aspects of Autoimmuni
ty
Room: MacDonald CD

Speaker 6 of 7
Yasuko Furumoto, NIAMS, National Institutes of Health, USA
Tofacitinib Inhibits Cell Metabolism in Activated T Cells

Sunday, April 07 | 2:30PM - 4:30PM
Workshop 2: Clinical and Translational Aspects of Autoimmuni
ty
Room: MacDonald CD

Speaker 7 of 7
Catia Verbeke, Harvard University, USA
Antigen-Specific Immune Modulation Using an Injectable Biomaterial

Sunday, April 07 | 4:30PM - 5:00PM
Coffee Available
Room: MacDonald Foyer


Sunday, April 07 | 5:00PM - 7:00PM
Lymphocytes in Autoimmunity I - B Cells
Room: MacDonald CD
Covers recent advances on B cells as promoters and regulators of immune responses and autoimmunity.
Speaker 1 of 5
* David M. Lee, Janssen Pharmaceutical Companies of Johnson & Johnson, USA

Sunday, April 07 | 5:00PM - 7:00PM
Lymphocytes in Autoimmunity I - B Cells
Room: MacDonald CD
Covers recent advances on B cells as promoters and regulators of immune responses and autoimmunity.
Speaker 2 of 5
Eric Meffre, Yale University School of Medicine, USA
Impact of Gene Mutations and Polymorphisms on Human B-Cell Tolerance

Sunday, April 07 | 5:00PM - 7:00PM
Lymphocytes in Autoimmunity I - B Cells
Room: MacDonald CD
Covers recent advances on B cells as promoters and regulators of immune responses and autoimmunity.
Speaker 3 of 5
Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Germany
Plasmablasts vs. Plasma Cells - Roles in Autoantibody Production

Sunday, April 07 | 5:00PM - 7:00PM
Lymphocytes in Autoimmunity I - B Cells
Room: MacDonald CD
Covers recent advances on B cells as promoters and regulators of immune responses and autoimmunity.
Speaker 4 of 5
Thomas F. Tedder, Duke University Medical Center, USA
Regulatory B Cells in Health and Disease: B10 Cells Negatively Regulate Autoimmunity

Sunday, April 07 | 5:00PM - 7:00PM
Lymphocytes in Autoimmunity I - B Cells
Room: MacDonald CD
Covers recent advances on B cells as promoters and regulators of immune responses and autoimmunity.
Speaker 5 of 5
Mohini K. Gray, MRC Centre for Inflammation Research, UK
Short Talk: A Tolerogenic Role for Toll-Like Receptor 9 Is Revealed by Regulatory
B-Cell Interaction with Apoptotic Cells


Sunday, April 07 | 5:00PM - 7:00PM
Immune Modulation and Effects of Immune Modulators on T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 1 of 5
* Fiona M. Powrie, University of Oxford, UK


Sunday, April 07 | 5:00PM - 7:00PM
Immune Modulation and Effects of Immune Modulators on T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 2 of 5
Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
Learning from Human Immunopathology to Develop Rational Treatments for Type 1 Diabetes


Sunday, April 07 | 5:00PM - 7:00PM
Immune Modulation and Effects of Immune Modulators on T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 3 of 5
Lucienne Chatenoud, INSERM U1151, Hôpital Necker-Enfants Malades, France
CD3 Antibodies in Established Autoimmunity: A Glass Half Empty or Half Full?


Sunday, April 07 | 5:00PM - 7:00PM
Immune Modulation and Effects of Immune Modulators on T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 4 of 5
Thomas R. Malek, University of Miami School of Medicine, USA
Short Talk: Human T Regulatory Cells Are Intrinsically More Sensitive to IL-2-Induced Signal Transduction Than T Effector and T Memory Cells


Sunday, April 07 | 5:00PM - 7:00PM
Immune Modulation and Effects of Immune Modulators on T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 5 of 5
Bart O. Roep, Leiden University Medical Center, Netherlands
Methods and Mechanisms of Immune Modulation in Humans


Sunday, April 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Frontenac Ballrm and Foyer


Sunday, April 07 | 7:30PM - 10:00PM
Poster Session 3
Room: Frontenac Ballrm and Foyer


Monday, April 08 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac Ballrm and Foyer


Monday, April 08 | 8:00AM - 11:15AM
Lymphocytes in Autoimmunity II - T Cells
Room: MacDonald CD
Discussion of T cell function in immunity and autoimmunity with emphasis on human immunology.
Speaker 1 of 6
Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
T Cell Subsets in Human Disease

Monday, April 08 | 8:00AM - 11:15AM
Lymphocytes in Autoimmunity II - T Cells
Room: MacDonald CD
Discussion of T cell function in immunity and autoimmunity with emphasis on human immunology.
Speaker 2 of 6
Shigeo Koyasu, Keio University School of Medicine, Japan
Role of Natural Helper Cell, a Member of the ILC (ILC2) in Steroid Resistance of Allergic Inflammation

Monday, April 08 | 8:00AM - 11:15AM
Lymphocytes in Autoimmunity II - T Cells
Room: MacDonald CD
Discussion of T cell function in immunity and autoimmunity with emphasis on human immunology.
Speaker 3 of 6
* Carola G. Vinuesa, Australian National University, Australia
Control of Tfh Cells

Monday, April 08 | 8:00AM - 11:15AM
Lymphocytes in Autoimmunity II - T Cells
Room: MacDonald CD
Discussion of T cell function in immunity and autoimmunity with emphasis on human immunology.
Speaker 4 of 6
Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Unexpected Targets and Triggers of Autoimmunity

Monday, April 08 | 8:00AM - 11:15AM
Lymphocytes in Autoimmunity II - T Cells
Room: MacDonald CD
Discussion of T cell function in immunity and autoimmunity with emphasis on human immunology.
Speaker 5 of 6
Xuezhi Dai, Seattle Childrens' Research Institute, USA
Short Talk: The PTPN22 Risk Variant Promotes Systemic Autoimmunity in Murine Models

Monday, April 08 | 8:00AM - 11:15AM
Lymphocytes in Autoimmunity II - T Cells
Room: MacDonald CD
Discussion of T cell function in immunity and autoimmunity with emphasis on human immunology.
Speaker 6 of 6
Anne R. Gocke, Johns Hopkins University, USA
Short Talk: Kv1.3 Deletion Induces Foxo1 Expression and Biases TH Cells Toward an Immunoregulatory Phenotype Independently of Foxp3

Monday, April 08 | 8:00AM - 11:30AM
Cellular and Environmental Networks in T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 1 of 7
* Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA


Monday, April 08 | 8:00AM - 11:30AM
Cellular and Environmental Networks in T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 2 of 7
Li Wen, Yale University, USA
Role of TLRs in Regulation of Autoimmunity and Beta Cells in Type 1 Diabetes


Monday, April 08 | 8:00AM - 11:30AM
Cellular and Environmental Networks in T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 3 of 7
Anne Cooke, University of Cambridge, UK
Epigenetic Modification of Induced Treg Cells: Implications for Therapy


Monday, April 08 | 8:00AM - 11:30AM
Cellular and Environmental Networks in T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 4 of 7
Agnès C. Lehuen, Institut Cochin, France
NKT Cells and Plasmacytoid DC in Type 1 Diabetes in Infectious and Non-Infectious Context


Monday, April 08 | 8:00AM - 11:30AM
Cellular and Environmental Networks in T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 5 of 7
David V. Serreze, The Jackson Laboratory, USA
To Be or Not To Be: Challenges in B-Lymphocyte Directed Interventions for Autoimmune Diabetes


Monday, April 08 | 8:00AM - 11:30AM
Cellular and Environmental Networks in T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 6 of 7
Lucy S. K. Walker, University College London, UK
Short Talk: Roles for IL-21 in Modulating T and B Cell Immunity in Autoimmune Diabetes


Monday, April 08 | 8:00AM - 11:30AM
Cellular and Environmental Networks in T1DM
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 7 of 7
Megan K. Levings, University of British Columbia, Canada
Molecular and Functional Properties of Regulatory T Cells


Monday, April 08 | 9:20AM - 9:40AM
Coffee Break
Room: MacDonald Foyer


Monday, April 08 | 11:15AM - 4:30PM
On Own for Lunch and Recreation


Monday, April 08 | 11:30AM - 12:30PM
NIDDK Planning Meeting: Future Needs and Priorities for Type
1 Diabetes Research
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 1 of 1
* Beena Akolkar, National Institutes of Health, USA


Monday, April 08 | 4:30PM - 5:00PM
Coffee Available
Room: MacDonald Foyer


Monday, April 08 | 5:00PM - 7:00PM
Systems Approaches to Autoimmunity
Room: MacDonald CD
What information is being gained by a systems approach toward the study of autoimmunity and how can we best utilize these vast data sets?
Speaker 1 of 5
* Virginia Pascual, Cornell University, USA

Monday, April 08 | 5:00PM - 7:00PM
Systems Approaches to Autoimmunity
Room: MacDonald CD
What information is being gained by a systems approach toward the study of autoimmunity and how can we best utilize these vast data sets?
Speaker 2 of 5
Nir Hacohen, Massachusetts General Hospital, USA
Deficiencies in DNases Lead to Autoimmunity

Monday, April 08 | 5:00PM - 7:00PM
Systems Approaches to Autoimmunity
Room: MacDonald CD
What information is being gained by a systems approach toward the study of autoimmunity and how can we best utilize these vast data sets?
Speaker 3 of 5
Edward K. Wakeland, University of Texas Southwestern Medical Center, USA
Genomic Analysis of Susceptibility to Autoimmunity

Monday, April 08 | 5:00PM - 7:00PM
Systems Approaches to Autoimmunity
Room: MacDonald CD
What information is being gained by a systems approach toward the study of autoimmunity and how can we best utilize these vast data sets?
Speaker 4 of 5
Soumya Raychaudhuri, Brigham and Women's Hospital, Harvard Medical School, USA
Genetics, Epigenetics, and Functional Genomics to Identify Critical Host Cell-Types in Autoimmunity

Monday, April 08 | 5:00PM - 7:00PM
Systems Approaches to Autoimmunity
Room: MacDonald CD
What information is being gained by a systems approach toward the study of autoimmunity and how can we best utilize these vast data sets?
Speaker 5 of 5
Bernd Wollscheid, ETH Zürich, Switzerland
Short Talk: Caught in the Act: LCR Technique for the Direct Identification of Endogenous Ligand-Receptor Interaction on Cells and Tissue

Monday, April 08 | 5:00PM - 7:00PM
The Future of T1DM Research and Clinical Translation
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 1 of 5
* Jeffrey A. Bluestone, University of California, San Francisco, USA


Monday, April 08 | 5:00PM - 7:00PM
The Future of T1DM Research and Clinical Translation
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 2 of 5
Linda S. Wicker, University of Cambridge, UK
IL-2 Therapy for Type 1 Diabetes


Monday, April 08 | 5:00PM - 7:00PM
The Future of T1DM Research and Clinical Translation
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 3 of 5
Paul L. Bollyky, Stanford University, USA
Short Talk: Hyaluronan Promotes Tonic STAT5 Signaling in Human Treg But this Effect Is Impaired in Type 1 Diabetes


Monday, April 08 | 5:00PM - 7:00PM
The Future of T1DM Research and Clinical Translation
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 4 of 5
Kevan C. Herold, Yale University, USA
Combination Therapies for Type 1 Diabetes


Monday, April 08 | 5:00PM - 7:00PM
The Future of T1DM Research and Clinical Translation
This session is from Type 1 Diabetes
Room: MacDonald AB

Speaker 5 of 5
Gerald T. Nepom, Benaroya Research Institute, USA
Next-Generation Therapeutic Opportunities and Challenges in T1D


Monday, April 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Frontenac Ballrm and Foyer


Monday, April 08 | 8:00PM - 11:00PM
Entertainment
Room: Frontenac Ballrm and Foyer


Monday, April 08 | 8:00PM - 11:00PM
Cash Bar
Room: Frontenac Ballroom


Tuesday, April 09 | 10:25AM - 10:25AM
Departure


*Session Chair.