Web Desc
The Ubiquitin System: From Basic Science to Drug Discovery
Organizer(s): Ingrid E. Wertz and David Komander
Date: January 07 - 12, 2014
Location: Big Sky Resort, Big Sky, MT, USA
Sponsored by Cell Research and Genentech, Inc.
Summary of Meeting:
Ubiquitination, the covalent ligation of target proteins by the 76-amino acid protein ubiquitin, regulates the fate and function of the substrate proteins. Aberrant ubiquitination promotes numerous disease states, but the mechanisms by which the ubiquitin system regulates cellular signaling and pathogenesis remain largely unknown. This meeting will: 1) Highlight recent basic science advances in the field of ubiquitin research; 2) Reveal gaps in our understanding of how the ubiquitin system regulates human disease, and how we can best apply our knowledge to answer these questions; and 3) Update attendees on the efficacy of drugs that target the ubiquitin/proteasome system. Initial plenary sessions will focus on the basic science of the ubiquitin system, including lectures describing ubiquitin modifications and the enzymology of the ubiquitin system. The role of ubiquitination in cellular signaling, with a focus on enzyme sub-classes and specific pathways, will next be explored. Workshops highlighting model systems and technological advances used to investigate the ubiquitin system are also incorporated. The meeting will culminate with sessions focused on the role of the ubiquitin system in human disease and as a drug target. The meeting format will encourage interaction between clinicians, translational researchers and basic scientists with interests ranging from the biophysics to the cellular biology of the ubiquitin system. The anticipated outcomes will be increased understanding of the interrelated roles that the ubiquitin system plays in normal homeostasis and in disease, and of the next steps required to target the ubiquitin system for patient benefit.
Scholarship Deadline: October 2 2013
Discounted Abstract Deadline: October 2 2013
Abstract Deadline: October 24 2013
Discounted Registration Deadline: November 7 2013
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Cell ResearchGenentech, Inc.
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Hoffmann-La Roche Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Biochemical Society / Biochemical Journal
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 07 | 4:00PM - 8:00PM
Arrival and Registration
Room: Lower Atrium


Wednesday, January 08 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Wednesday, January 08 | 8:00AM - 9:00AM
Keynote Address
Room: Jefferson/Madison

Speaker 1 of 2
* Ingrid E. Wertz, Genentech, Inc., USA

Wednesday, January 08 | 8:00AM - 9:00AM
Keynote Address
Room: Jefferson/Madison

Speaker 2 of 2
Raymond J. Deshaies, Amgen, Inc., USA
Exploiting Protein Homeostasis as a Target for Anti-Cancer Drugs

Wednesday, January 08 | 9:00AM - 11:00AM
Ubiquitin Chains and Modifications
Room: Jefferson/Madison

Speaker 1 of 4
* Henning Walczak, University College London, Cancer Institute, UK

Wednesday, January 08 | 9:00AM - 11:00AM
Ubiquitin Chains and Modifications
Room: Jefferson/Madison

Speaker 2 of 4
David Komander, Walter and Eliza Hall Institute of Medical Research, Australia
Atypical Ubiquitin Chains

Wednesday, January 08 | 9:00AM - 11:00AM
Ubiquitin Chains and Modifications
Room: Jefferson/Madison

Speaker 3 of 4
Michael Rape, University of California, Berkeley, USA
Tumor Suppression by Mitotic Quality Control

Wednesday, January 08 | 9:00AM - 11:00AM
Ubiquitin Chains and Modifications
Room: Jefferson/Madison

Speaker 4 of 4
Ingrid E. Wertz, Genentech, Inc., USA
Ubiquitin Editing

Wednesday, January 08 | 9:40AM - 10:00AM
Coffee Break
Room: Lower Atrium


Wednesday, January 08 | 11:00AM - 1:00PM
Poster Setup
Room: Gallatin


Wednesday, January 08 | 11:00AM - 2:30PM
On Own for Lunch and Recreation


Wednesday, January 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Wednesday, January 08 | 2:30PM - 4:30PM
Workshop 1: Technological Advances for Interrogating the Ubi
quitin Proteasome System
Room: Jefferson/Madison

Speaker 1 of 8
* Ingrid E. Wertz, Genentech, Inc., USA

Wednesday, January 08 | 2:30PM - 4:30PM
Workshop 1: Technological Advances for Interrogating the Ubi
quitin Proteasome System
Room: Jefferson/Madison

Speaker 2 of 8
Marie-Pierre Bousquet, IPBS - CNRS, University of Toulouse, France
Determination of Proteasome Subcellular Distribution and Molecular Stoichiometry Using Formaldehyde Cross-Linking and Label-Free Quantitative Proteomics

Wednesday, January 08 | 2:30PM - 4:30PM
Workshop 1: Technological Advances for Interrogating the Ubi
quitin Proteasome System
Room: Jefferson/Madison

Speaker 3 of 8
Kevin G. Mark, University of California, San Francisco, USA
Ubiquitin Ligase Substrate Trapping Identifies an Scf-saf1 Mediated Pathway Targeting Unprocessed Vacuolar/Lysosomal Proteins

Wednesday, January 08 | 2:30PM - 4:30PM
Workshop 1: Technological Advances for Interrogating the Ubi
quitin Proteasome System
Room: Jefferson/Madison

Speaker 4 of 8
Gregg Siegal, ZoBio, Netherlands
Drugging DUBs with an NMR Pyramid

Wednesday, January 08 | 2:30PM - 4:30PM
Workshop 1: Technological Advances for Interrogating the Ubi
quitin Proteasome System
Room: Jefferson/Madison

Speaker 5 of 8
John S. Schneekloth, Jr., NCI, National Institutes of Health, USA
Discovery and Characterization of Small Molecule Probes of Sumoylation Enzymes

Wednesday, January 08 | 2:30PM - 4:30PM
Workshop 1: Technological Advances for Interrogating the Ubi
quitin Proteasome System
Room: Jefferson/Madison

Speaker 6 of 8
Reggy Ekkebus, Netherlands Cancer Institute, Netherlands
and

Wednesday, January 08 | 2:30PM - 4:30PM
Workshop 1: Technological Advances for Interrogating the Ubi
quitin Proteasome System
Room: Jefferson/Madison

Speaker 7 of 8
Paul Geurink, Netherlands Cancer Institute, Netherlands
and

Wednesday, January 08 | 2:30PM - 4:30PM
Workshop 1: Technological Advances for Interrogating the Ubi
quitin Proteasome System
Room: Jefferson/Madison

Speaker 8 of 8
Monique PC Mulder, Netherlands Cancer Institute, NKI, Netherlands
Probing Protein Ubiquitination: A Chemical Biology Approach

Wednesday, January 08 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Wednesday, January 08 | 5:00PM - 7:15PM
Ubiquitin Proteasome System Enzymes: Structural Insights and
Biophysical Mechanisms

Room: Jefferson/Madison

Speaker 1 of 7
* David Komander, Walter and Eliza Hall Institute of Medical Research, Australia

Wednesday, January 08 | 5:00PM - 7:15PM
Ubiquitin Proteasome System Enzymes: Structural Insights and
Biophysical Mechanisms

Room: Jefferson/Madison

Speaker 2 of 7
Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Structural and Mechanistic Studies of Cullin-RING Ligases

Wednesday, January 08 | 5:00PM - 7:15PM
Ubiquitin Proteasome System Enzymes: Structural Insights and
Biophysical Mechanisms

Room: Jefferson/Madison

Speaker 3 of 7
Eric S. Fischer, Dana-Farber Cancer Institute, USA
Short Talk: The Structure of an DDB1-CRBN Complex Bound to Thalidomide: Insights into CRL4 Inhibition by Small Molecules

Wednesday, January 08 | 5:00PM - 7:15PM
Ubiquitin Proteasome System Enzymes: Structural Insights and
Biophysical Mechanisms

Room: Jefferson/Madison

Speaker 4 of 7
Simin Rahighi, Stanford University, USA
Short Talk: Structural Basis for the Recognition of a Lys48-Linked Tri-Ubiquitin Chain by the Tandem UIMs of AIRAPL

Wednesday, January 08 | 5:00PM - 7:15PM
Ubiquitin Proteasome System Enzymes: Structural Insights and
Biophysical Mechanisms

Room: Jefferson/Madison

Speaker 5 of 7
R. Andrew Byrd, NCI, National Institutes of Health, USA
Short Talk: Dissecting a Processive Ubiquitination Machine: Dynamic Interplay and Allostery Associated with Secondary Binding Domains of the Ubiquitin RING-Finger Ligase gp78

Wednesday, January 08 | 5:00PM - 7:15PM
Ubiquitin Proteasome System Enzymes: Structural Insights and
Biophysical Mechanisms

Room: Jefferson/Madison

Speaker 6 of 7
Evan J. Worden, University of California, Berkeley, USA
Short Talk: Allosteric Regulation and Substrate Specificity of the Proteasome Deubiquitinase Rpn11

Wednesday, January 08 | 5:00PM - 7:15PM
Ubiquitin Proteasome System Enzymes: Structural Insights and
Biophysical Mechanisms

Room: Jefferson/Madison

Speaker 7 of 7
Vishva M. Dixit, Genentech, Inc., USA
Ubiquitin-Mediated Modulation of Epigenetics

Wednesday, January 08 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Gallatin


Wednesday, January 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Gallatin


Thursday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Thursday, January 09 | 8:00AM - 11:00AM
Ubiquitin-Like Proteins in Cellular Signaling
Room: Jefferson/Madison

Speaker 1 of 6
* Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany

Thursday, January 09 | 8:00AM - 11:00AM
Ubiquitin-Like Proteins in Cellular Signaling
Room: Jefferson/Madison

Speaker 2 of 6
Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA
Structure and Function in Ub/Ubl Conjugation Pathways

Thursday, January 09 | 8:00AM - 11:00AM
Ubiquitin-Like Proteins in Cellular Signaling
Room: Jefferson/Madison

Speaker 3 of 6
Marcus Groettrup, University of Konstanz, Germany
The Ubiquitin-Like Modifier FAT10 Shapes the T Lymphocyte Repertoire

Thursday, January 09 | 8:00AM - 11:00AM
Ubiquitin-Like Proteins in Cellular Signaling
Room: Jefferson/Madison

Speaker 4 of 6
Heran Darwin, New York University School of Medicine, USA
Latest Developments in the Pup-Proteasome System of Mycobacterium tuberculosis

Thursday, January 09 | 8:00AM - 11:00AM
Ubiquitin-Like Proteins in Cellular Signaling
Room: Jefferson/Madison

Speaker 5 of 6
Sreenivas Gannavaram, US Food and Drug Administration, USA
Short Talk: Ufm1 Mediated Protein Modification Pathway as Drug Target in the Human Protozoan Parasite Leishmania donovani

Thursday, January 09 | 8:00AM - 11:00AM
Ubiquitin-Like Proteins in Cellular Signaling
Room: Jefferson/Madison

Speaker 6 of 6
Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
Why Is Addition and Removal of SUMO so Dynamic?

Thursday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Thursday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Gallatin


Thursday, January 09 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Thursday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Thursday, January 09 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Thursday, January 09 | 5:00PM - 7:15PM
Regulation of Signaling Pathways by the Ubiquitin Proteasome
System

Room: Jefferson/Madison

Speaker 1 of 7
* Cynthia Wolberger, Johns Hopkins University School of Medicine, USA

Thursday, January 09 | 5:00PM - 7:15PM
Regulation of Signaling Pathways by the Ubiquitin Proteasome
System

Room: Jefferson/Madison

Speaker 2 of 7
Henning Walczak, University College London, Cancer Institute, UK
Linear Ubiquitin: New Insight on its Role in Signaling and Development

Thursday, January 09 | 5:00PM - 7:15PM
Regulation of Signaling Pathways by the Ubiquitin Proteasome
System

Room: Jefferson/Madison

Speaker 3 of 7
Brittney M. Davidge, Portland State University, USA
Short Talk: The Cul3 Mutant Associated with Hypertension Is an Active Ubiquitin Ligase

Thursday, January 09 | 5:00PM - 7:15PM
Regulation of Signaling Pathways by the Ubiquitin Proteasome
System

Room: Jefferson/Madison

Speaker 4 of 7
Nicolas Bidère, INSERM, France
Short Talk: A Role for the LUBAC in Antigen Receptor-Mediated NF-kappaB Activation and in Lymphoma Survival

Thursday, January 09 | 5:00PM - 7:15PM
Regulation of Signaling Pathways by the Ubiquitin Proteasome
System

Room: Jefferson/Madison

Speaker 5 of 7
Arno F. Alpi, University of Dundee, UK
Short Talk: TRIAD1 and HHARI Modulate the Activity of Distinct Cullin Ring Ligase Complexes

Thursday, January 09 | 5:00PM - 7:15PM
Regulation of Signaling Pathways by the Ubiquitin Proteasome
System

Room: Jefferson/Madison

Speaker 6 of 7
Paula M. Oliver, University of Pennsylvania, USA
Short Talk: Activating Ubiquitin Complexes that Prevent Inflammation

Thursday, January 09 | 5:00PM - 7:15PM
Regulation of Signaling Pathways by the Ubiquitin Proteasome
System

Room: Jefferson/Madison

Speaker 7 of 7
Ivan Dikic, Goethe University Medical School, Germany
Regulation of Autophagy by Ubiquitin Networks

Thursday, January 09 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Gallatin


Thursday, January 09 | 7:30PM - 10:00PM
Poster Session 2
Room: Gallatin


Friday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Friday, January 10 | 8:00AM - 11:30AM
Ubiquitin Ligases in Cellular Signaling
Room: Jefferson/Madison

Speaker 1 of 8
* Michael Rape, University of California, Berkeley, USA

Friday, January 10 | 8:00AM - 11:30AM
Ubiquitin Ligases in Cellular Signaling
Room: Jefferson/Madison

Speaker 2 of 8
Rachel Klevit, University of Washington, USA
How to Modulate Ub E3 Ligase Activity

Friday, January 10 | 8:00AM - 11:30AM
Ubiquitin Ligases in Cellular Signaling
Room: Jefferson/Madison

Speaker 3 of 8
Simona Polo, FIRC Institute of Molecular Oncology, Italy
The Ubiquitin Signaling Network at Work

Friday, January 10 | 8:00AM - 11:30AM
Ubiquitin Ligases in Cellular Signaling
Room: Jefferson/Madison

Speaker 4 of 8
Wenyi Wei, Beth Israel Deaconess Medical Center, USA
MC1R Deficiency Cooperates with BRaf V600E to Promote Melanomogenesis

Friday, January 10 | 8:00AM - 11:30AM
Ubiquitin Ligases in Cellular Signaling
Room: Jefferson/Madison

Speaker 5 of 8
Wolfgang Dubiel, Charité - Universitätsmedizin Berlin, Germany
Short Talk: The COP9 Signalosome is Essential for Adipogenesis

Friday, January 10 | 8:00AM - 11:30AM
Ubiquitin Ligases in Cellular Signaling
Room: Jefferson/Madison

Speaker 6 of 8
Ryan Potts, Amgen, USA
Short Talk: Regulation of Cellular Metabolism by an Oncogenic MAGE-RING E3 Ubiquitin Ligase Targeting AMPK

Friday, January 10 | 8:00AM - 11:30AM
Ubiquitin Ligases in Cellular Signaling
Room: Jefferson/Madison

Speaker 7 of 8
Pengbo Zhou, Weill Cornell Medical College, USA
Short Talk: Recurrent Missense Mutations in the SPOP-CUL3 Ubiquitin Ligase in Prostate Cancer

Friday, January 10 | 8:00AM - 11:30AM
Ubiquitin Ligases in Cellular Signaling
Room: Jefferson/Madison

Speaker 8 of 8
Matthias Peter, ETH Zürich, Switzerland
Function and Regulation of CRL Complexes

Friday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Friday, January 10 | 11:30AM - 1:00PM
Poster Setup
Room: Gallatin


Friday, January 10 | 11:30AM - 2:30PM
On Own for Lunch and Recreation


Friday, January 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Friday, January 10 | 2:30PM - 4:30PM
Workshop 2: Ubiquitin Proteasome System: Insights from Model
Systems
Room: Jefferson/Madison

Speaker 1 of 7
* David Komander, Walter and Eliza Hall Institute of Medical Research, Australia

Friday, January 10 | 2:30PM - 4:30PM
Workshop 2: Ubiquitin Proteasome System: Insights from Model
Systems
Room: Jefferson/Madison

Speaker 2 of 7
* Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Regulation of Innate Immunity by TRIM E3 Ligases

Friday, January 10 | 2:30PM - 4:30PM
Workshop 2: Ubiquitin Proteasome System: Insights from Model
Systems
Room: Jefferson/Madison

Speaker 3 of 7
Pascale Cossart, Institut Pasteur, France
Role of SUMOylation in Listeria monocytogenes Infection

Friday, January 10 | 2:30PM - 4:30PM
Workshop 2: Ubiquitin Proteasome System: Insights from Model
Systems
Room: Jefferson/Madison

Speaker 4 of 7
Wim Vandenberghe, University Hospitals Leuven, Belgium
Identification of a Deubiquitinase that Antagonizes Parkin-Mediated Mitochondrial Ubiquitination and Mitophagy

Friday, January 10 | 2:30PM - 4:30PM
Workshop 2: Ubiquitin Proteasome System: Insights from Model
Systems
Room: Jefferson/Madison

Speaker 5 of 7
Michael A. Skinner, Imperial College London Faculty of Medicine, UK
Interaction of a Fowlpox Virus Modulator of Avian Interferon with the Chicken Cullin-1 and Skp1

Friday, January 10 | 2:30PM - 4:30PM
Workshop 2: Ubiquitin Proteasome System: Insights from Model
Systems
Room: Jefferson/Madison

Speaker 6 of 7
Josua Schinke, Georg-August University Göttingen, Germany
Interplay between Den1 and CSN Deneddylases and the Phosphatase DipA in Filamentous Fungi

Friday, January 10 | 2:30PM - 4:30PM
Workshop 2: Ubiquitin Proteasome System: Insights from Model
Systems
Room: Jefferson/Madison

Speaker 7 of 7
Christoph Geisen, Max Planck Institute for Biology of Ageing, Germany
BLMP-1/BLIMP-1 Is a Novel Substrate of DRE-1/FBXO11 Regulating Developmental Timing

Friday, January 10 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Friday, January 10 | 5:00PM - 7:00PM
Deubiquitinase Enzymes in Cellular Signaling
Room: Jefferson/Madison

Speaker 1 of 6
* Xavier Jacq, MISSION Therapeutics Ltd., UK

Friday, January 10 | 5:00PM - 7:00PM
Deubiquitinase Enzymes in Cellular Signaling
Room: Jefferson/Madison

Speaker 2 of 6
Titia K. Sixma, Netherlands Cancer Institute, Netherlands
Regulation of DUB Activity by Protein-Protein Interaction

Friday, January 10 | 5:00PM - 7:00PM
Deubiquitinase Enzymes in Cellular Signaling
Room: Jefferson/Madison

Speaker 3 of 6
Paul J. Galardy, Mayo Clinic, USA
Short Talk: USP44 Is an Essential Regulator of Nucleotide Excision Repair

Friday, January 10 | 5:00PM - 7:00PM
Deubiquitinase Enzymes in Cellular Signaling
Room: Jefferson/Madison

Speaker 4 of 6
Nima Mosammaparast, Washington University in St. Louis, USA
Short Talk: Regulation of DNA Demethylation Repair by the OTUD4 Deubiquitinase

Friday, January 10 | 5:00PM - 7:00PM
Deubiquitinase Enzymes in Cellular Signaling
Room: Jefferson/Madison

Speaker 5 of 6
Judy Coulson, University of Liverpool, UK
Short Talk: The Deubiquitylase Ataxin-3 Restricts PTEN Transcription and PI3K Signaling

Friday, January 10 | 5:00PM - 7:00PM
Deubiquitinase Enzymes in Cellular Signaling
Room: Jefferson/Madison

Speaker 6 of 6
Cynthia Wolberger, Johns Hopkins University School of Medicine, USA
Cross-regulation by Deubiquitinating and E2 Enzymes

Friday, January 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Gallatin


Friday, January 10 | 7:30PM - 10:00PM
Poster Session 3
Room: Gallatin


Saturday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Saturday, January 11 | 8:00AM - 11:00AM
The Ubiquitin Proteasome System as a Drug Target
Room: Jefferson/Madison

Speaker 1 of 7
* Ivan Dikic, Goethe University Medical School, Germany

Saturday, January 11 | 8:00AM - 11:00AM
The Ubiquitin Proteasome System as a Drug Target
Room: Jefferson/Madison

Speaker 2 of 7
Gwen Nichols, Hoffmann-LaRoche, USA
Drugging E3 Ligases: MDM2 Antagonist Clinical Development

Saturday, January 11 | 8:00AM - 11:00AM
The Ubiquitin Proteasome System as a Drug Target
Room: Jefferson/Madison

Speaker 3 of 7
Christopher J. Kirk, Kezar Life Sciences, USA
Peptide Epoxyketone Proteasome Inhibitors: Tools and Drugs

Saturday, January 11 | 8:00AM - 11:00AM
The Ubiquitin Proteasome System as a Drug Target
Room: Jefferson/Madison

Speaker 4 of 7
Jennifer A. Johnston, E3xBio, USA
Short Talk: Identification of Small Molecule Activators of Parkin Protein and Insight into Mechanisms of Enzyme Activation

Saturday, January 11 | 8:00AM - 11:00AM
The Ubiquitin Proteasome System as a Drug Target
Room: Jefferson/Madison

Speaker 5 of 7
Namrata D. Udeshi, Broad Institute of MIT and Harvard, USA
Short Talk: Lenalidomide Promotes CRBN-Mediated Ubiquitination and Degradation of IKZF1 and IKZF3

Saturday, January 11 | 8:00AM - 11:00AM
The Ubiquitin Proteasome System as a Drug Target
Room: Jefferson/Madison

Speaker 6 of 7
Derek F. Ceccarelli, Samuel Lunenfeld Research Institute, Canada
Short Talk: E2 Enzyme Inhibition by Stabilization of a Low Affinity Interface with Ubiquitin

Saturday, January 11 | 8:00AM - 11:00AM
The Ubiquitin Proteasome System as a Drug Target
Room: Jefferson/Madison

Speaker 7 of 7
Xavier Jacq, MISSION Therapeutics Ltd., UK
Identification of Selective DUB Inhibitors Targeting DDR Deficient Tumors

Saturday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Saturday, January 11 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Saturday, January 11 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Saturday, January 11 | 5:00PM - 7:00PM
The Ubiquitin Proteasome System in Disease
Room: Jefferson/Madison

Speaker 1 of 6
* Titia K. Sixma, Netherlands Cancer Institute, Netherlands

Saturday, January 11 | 5:00PM - 7:00PM
The Ubiquitin Proteasome System in Disease
Room: Jefferson/Madison

Speaker 2 of 6
Iannis Aifantis, New York University School of Medicine, USA
Regulation of Leukemia Initiation and Progression by the Ubiquitin System

Saturday, January 11 | 5:00PM - 7:00PM
The Ubiquitin Proteasome System in Disease
Room: Jefferson/Madison

Speaker 3 of 6
Alain Israël, Institut Pasteur, France
Ubiquitination in NF-kappaB Signaling

Saturday, January 11 | 5:00PM - 7:00PM
The Ubiquitin Proteasome System in Disease
Room: Jefferson/Madison

Speaker 4 of 6
Khosrow Rezvani, University of South Dakota, USA
Short Talk: Ubiquitin-Like (UBX)-Domain-Containing Protein, UBXN2A, Promotes Cell Death by Interfering with the p53-Mortalin2 Interactions in Cancer Cells

Saturday, January 11 | 5:00PM - 7:00PM
The Ubiquitin Proteasome System in Disease
Room: Jefferson/Madison

Speaker 5 of 6
Alexandre Orthwein, Jewish General Hospital, Canada
Short Talk: Mitotic Inhibition of RNF8/RNF168- Medicated Ubiquitylation Cascade Preserves Genomic Integrity

Saturday, January 11 | 5:00PM - 7:00PM
The Ubiquitin Proteasome System in Disease
Room: Jefferson/Madison

Speaker 6 of 6
Daniel J. Finley, Harvard University, USA
Regulation of Proteasome Activity by Ubiquitin Chain Editing

Saturday, January 11 | 7:00PM - 7:15PM
Closing Remarks
Room: Jefferson/Madison

Speaker 1 of 1
David Komander, Walter and Eliza Hall Institute of Medical Research, Australia

Saturday, January 11 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Gallatin


Saturday, January 11 | 8:00PM - 11:00PM
Entertainment
Room: Gallatin


Saturday, January 11 | 8:30PM - 11:00PM
Cash Bar
Room: Gallatin


Sunday, January 12 | 10:25AM - 10:25AM
Departure


*Session Chair.