Web Desc
Tissue-Resident Memory T Cells
Organizer(s): Cornelia L. Trimble, Rachael A. Clark, Leo Lefrançois (in memoriam) and David Masopust
Date: January 12 - 16, 2014
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by BioLegend, Inc. Supported by an educational donation provided by Amgen.
Summary of Meeting:
Infections that are encountered through epithelial barrier tissues such as the skin, gut, lung and genitourinary tract generate a population of tissue-resident T cells that remain sessile long-term in the affected tissue, and are protective against re-infection. Indeed, most effector memory T cells reside in non-sterile barrier epithelial tissues, as opposed to the circulation. While tissue-resident T cells play a critical role in defending against infections and cancer, aberrant activation of these cells gives rise to inflammatory and autoimmune conditions, including psoriasis, multiple sclerosis and inflammatory bowel disease. Tissue-resident T cells are not simply T cells in an unexpected location; these cells have many phenotypic and functional differences that distinguish them from circulating T cells. This conference will bring together basic and translational immunologists to discuss tissue-localized mechanisms of immune cell recruitment, retention, activation and homeostasis. The major objectives will be to: 1) Explore the roles that tissue immune cells play in immune surveillance, including recall responses to infectious pathogens, and mechanisms of dysregulation leading to autoimmune disease; 2) Examine the mechanisms by which immune responses can be shaped by the local tissue microbiome; 3) Investigate the mechanisms by which immune responses can be subverted by chronic infections or early neoplastic lesions; and 4) Discuss the rationale for immunotherapeutic strategies targeting specific tissue sites. A better understanding of the biology of tissue-resident T cells will inform vaccination strategies for both infections and cancer, as well as novel therapies for inflammatory and autoimmune diseases.
Scholarship Deadline: October 3 2013
Discounted Abstract Deadline: October 3 2013
Abstract Deadline: October 28 2013
Discounted Registration Deadline: November 13 2013
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Educational donation provided by Amgen.BioLegend, Inc.
We gratefully acknowledge additional support for this conference from:
Mucosal Immunology Studies Team (MIST), in memory of Dr. Leo LeFrancois
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI109814-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 12 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Monday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Ballroom 1-2


Monday, January 13 | 8:00AM - 9:00AM
Keynote Address
Room: Ballroom 3

Speaker 1 of 1
Peter C. Doherty, University of Melbourne, Australia
Thinking about Memory

Monday, January 13 | 9:00AM - 11:30AM
Tissue-Resident T Cells: What Are the Questions?
Room: Ballroom 3

Speaker 1 of 6
* Philip D. Greenberg, University of Washington, USA

Monday, January 13 | 9:00AM - 11:30AM
Tissue-Resident T Cells: What Are the Questions?
Room: Ballroom 3

Speaker 2 of 6
Wolf-Hervé Fridman, Cordeliers Research Centre, France
Role of Tumor-Associated Tertiary Lymphoid Structures in the Generation and Shaping of Cancer-Controlling T Lymphocytes

Monday, January 13 | 9:00AM - 11:30AM
Tissue-Resident T Cells: What Are the Questions?
Room: Ballroom 3

Speaker 3 of 6
Harlan Robins, Adaptive Biotechnologies, USA
Immunosequencing Tumor-Infiltrating Lymphocytes in Ovarian and Colon Tumors

Monday, January 13 | 9:00AM - 11:30AM
Tissue-Resident T Cells: What Are the Questions?
Room: Ballroom 3

Speaker 4 of 6
Nelson Glennie, University of Pennsylvania, USA
Short Talk: The Role of Skin-Localized Memory CD4 T Cells in Protection against Leishmania major

Monday, January 13 | 9:00AM - 11:30AM
Tissue-Resident T Cells: What Are the Questions?
Room: Ballroom 3

Speaker 5 of 6
Jenny Thom, ETH Zürich, Switzerland
Short Talk: Cytomegalovirus Infection Results in the Formation of CD8+ and CD4+ Tissue Resident Memory T Cells in the Salivary Glands

Monday, January 13 | 9:00AM - 11:30AM
Tissue-Resident T Cells: What Are the Questions?
Room: Ballroom 3

Speaker 6 of 6
Thomas S. Kupper, Brigham and Women's Hospital, USA
Barrier Epithelial Tissues as Immune Organs

Monday, January 13 | 9:40AM - 10:00AM
Coffee Break
Room: Ballroom Lobby


Monday, January 13 | 11:30AM - 1:00PM
Poster Setup
Room: Ballroom 1-2


Monday, January 13 | 11:30AM - 12:30PM
Navigating NIAID: Funding Priorities, Processes and Resource
s
Room: Ballroom 3

Speaker 1 of 2
* † Cheryl Lapham, NIAID, National Institutes of Health, USA

Monday, January 13 | 11:30AM - 12:30PM
Navigating NIAID: Funding Priorities, Processes and Resource
s
Room: Ballroom 3

Speaker 2 of 2
* Halonna Kelly, NIH: Division of Allergy, Immunology, and Transplantation (DAIT), USA

Monday, January 13 | 11:30AM - 2:30PM
On Own for Lunch and Recreation


Monday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom 1-2


Monday, January 13 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 3

Speaker 1 of 8
Joshua T. Schiffer, Fred Hutchinson Cancer Research Center, USA
Contribution of Decay and Movement to CD8+ T-Cell Decline from Genital Tract Micro-Regions following Clearance of HSV-2 Infected Cells: Predictions from a Mathematical Model

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 3

Speaker 2 of 8
Georg Stary, Harvard Medical School, USA
Induction of Tissue-Resident Memory CD4+ T Cells in the Genital Tract by Intranasal Application of a Nanoparticle-Based Chlamydia Vaccine

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 3

Speaker 3 of 8
Elizabeth L. Frost, Pennsylvania State University College of Medicine, USA
Requirements for the Development and Maintenance of Mouse Polyomavirus-Specific Brain Resident Memory CD8+ T Cells

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 3

Speaker 4 of 8
Tyler A. Landrith, University of California, Riverside, USA
Characterization of CD103+ CD8+ T Cell Populations Present in the Brain during Chronic Toxoplasma gondii Infection

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 3

Speaker 5 of 8
Jennifer M. Lund, Fred Hutchinson Cancer Research Center, USA
Regulatory T Cells Shape the Resident Memory T Cell Response to Virus Infection in the Tissues

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 3

Speaker 6 of 8
Pablo A. Romagnoli, University of Connecticut Health Center, USA
Memory gammadelta T Cells Orchestrate Response to Secondary Oral Lm Infection

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 3

Speaker 7 of 8
* Marion Pepper, University of Washington, USA
Visualizing Allergen-Specific Lung-Resident CD4+ Th2 Memory Cells in Asthma

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 3

Speaker 8 of 8
Kristin Anderson, University of Washington, USA
Recirculation and Residence of Memory CD8 T Cells in the Murine Lung

Monday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, January 13 | 5:00PM - 7:00PM
Site-Specific: Reproductive Tract Mucosa
Room: Ballroom 3

Speaker 1 of 4
* Cornelia Liu Trimble, Johns Hopkins University School of Medicine, USA
Tissue T Cells in Preinvasive HPV Disease

Monday, January 13 | 5:00PM - 7:00PM
Site-Specific: Reproductive Tract Mucosa
Room: Ballroom 3

Speaker 2 of 4
Nicolas Cuburu, NIH, National Cancer Institute, USA
Intravaginal Vaccination with Human Papillomavirus Vectors Against Herpes Simplex Virus 2 Infection

Monday, January 13 | 5:00PM - 7:00PM
Site-Specific: Reproductive Tract Mucosa
Room: Ballroom 3

Speaker 3 of 4
Norifumi Iijima, Yale University School of Medicine, USA
Short Talk: A Local Chemokine Network Sustains Tissue-Resident Memory T Cells Crucial for Antiviral Protection

Monday, January 13 | 5:00PM - 7:00PM
Site-Specific: Reproductive Tract Mucosa
Room: Ballroom 3

Speaker 4 of 4
Lawrence Corey, Fred Hutchinson Cancer Research Center, USA

Monday, January 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 1-2


Monday, January 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Ballroom 1-2


Tuesday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliffs/Eagles


Tuesday, January 14 | 8:00AM - 11:15AM
Imprinting and Plasticity
Room: Ballroom 2-3

Speaker 1 of 6
Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
Transcriptional Basis of Dendritic Cell Diversity in T Cell Priming

Tuesday, January 14 | 8:00AM - 11:15AM
Imprinting and Plasticity
Room: Ballroom 2-3

Speaker 2 of 6
David B. Masopust, University of Minnesota, USA
Characterization of Tissue-Resident Memory CD8 T Cells in Mice: Distribution, Differentiation, and Function

Tuesday, January 14 | 8:00AM - 11:15AM
Imprinting and Plasticity
Room: Ballroom 2-3

Speaker 3 of 6
Brian J. Laidlaw, University of California, San Francisco, USA
Short Talk: CD4 Help Is Critical for the Formation of Tissue Resident Memory T Cells following Influenza Infection

Tuesday, January 14 | 8:00AM - 11:15AM
Imprinting and Plasticity
Room: Ballroom 2-3

Speaker 4 of 6
Naomi A. Yudanin, Weill Cornell Medical College, USA
Short Talk: Mechanisms of Lung-Resident Memory CD4 T Cell Migration and Retention

Tuesday, January 14 | 8:00AM - 11:15AM
Imprinting and Plasticity
Room: Ballroom 2-3

Speaker 5 of 6
Stephen C. Jameson, University of Minnesota Medical School, USA
Putting T Cells in their Place

Tuesday, January 14 | 8:00AM - 11:15AM
Imprinting and Plasticity
Room: Ballroom 2-3

Speaker 6 of 6
* Marc K. Jenkins, University of Minnesota Medical School, USA
Origins of CD4+ Memory T Cells

Tuesday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Tuesday, January 14 | 11:15AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby


Tuesday, January 14 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby


Tuesday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, January 14 | 5:00PM - 7:15PM
Site-Specific: GI Tract
Room: Ballroom 2-3

Speaker 1 of 6
* David B. Masopust, University of Minnesota, USA

Tuesday, January 14 | 5:00PM - 7:15PM
Site-Specific: GI Tract
Room: Ballroom 2-3

Speaker 2 of 6
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Compartmentalized and Systemic Control of Tissue Immunity by Commensals

Tuesday, January 14 | 5:00PM - 7:15PM
Site-Specific: GI Tract
Room: Ballroom 2-3

Speaker 3 of 6
Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
From Transcription Factors to Defense Mechanisms: Different Rules Apply for Mucosal Effector Memory T Cells

Tuesday, January 14 | 5:00PM - 7:15PM
Site-Specific: GI Tract
Room: Ballroom 2-3

Speaker 4 of 6
Livija Deban, Prokarium Ltd., UK
Short Talk: RGS1 Is a Major Regulator of Intestinal TRM Cell Responsiveness

Tuesday, January 14 | 5:00PM - 7:15PM
Site-Specific: GI Tract
Room: Ballroom 2-3

Speaker 5 of 6
Charisse Petersen, University of Utah, USA
Short Talk: Direct Recognition of Commensals by T Cells Promotes Microbiota Selection by IgA to Prevent Dysbiosis

Tuesday, January 14 | 5:00PM - 7:15PM
Site-Specific: GI Tract
Room: Ballroom 2-3

Speaker 6 of 6
Gregory F. Sonnenberg, Weill Cornell Medicine, USA
Regulation of Host-Commensal Bacteria Relationships in Human Health and Disease

Tuesday, January 14 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby


Tuesday, January 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby


Wednesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Ballroom 2


Wednesday, January 15 | 8:00AM - 11:15AM
Site-Specific: Skin
Room: Ballroom 3

Speaker 1 of 6
* Rachael A. Clark, Brigham and Women's Hospital, Harvard Medical School, USA
Unique Features of Human Skin Resident T Cells

Wednesday, January 15 | 8:00AM - 11:15AM
Site-Specific: Skin
Room: Ballroom 3

Speaker 2 of 6
Wendy L. Havran, The Scripps Research Institute, USA
Crosstalk between Skin-Resident T Cells and their Neighbors

Wednesday, January 15 | 8:00AM - 11:15AM
Site-Specific: Skin
Room: Ballroom 3

Speaker 3 of 6
Shruti Naik, New York University, USA
Short Talk: Specific Commensal-Dendritic Cell Crosstalk Promotes Cutaneous IL-17A+ CD8 T Effectors

Wednesday, January 15 | 8:00AM - 11:15AM
Site-Specific: Skin
Room: Ballroom 3

Speaker 4 of 6
Erika J. Crosby, Duke University, USA
Short Talk: Bystander CD8 T Cells in the Skin Promote Increased Disease Severity during Leishmania Major Infection

Wednesday, January 15 | 8:00AM - 11:15AM
Site-Specific: Skin
Room: Ballroom 3

Speaker 5 of 6
Laura K. Mackay, University of Melbourne, Australia
Generation of Epithelial Resident Memory T Cells

Wednesday, January 15 | 8:00AM - 11:15AM
Site-Specific: Skin
Room: Ballroom 3

Speaker 6 of 6
Frank Oliver Nestle, Sanofi, USA
Regulation of Skin T Cells in Skin Homeostasis and Pathology

Wednesday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Wednesday, January 15 | 11:15AM - 2:30PM
On Own for Lunch and Recreation


Wednesday, January 15 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 3

Speaker 1 of 9
* Donna L. Farber, Columbia University Medical Center, USA

Wednesday, January 15 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 3

Speaker 2 of 9
Marcia A. Blackman, Trudeau Institute, USA
Effect of Aging on Tissue-Resident Memory to Influenza Virus

Wednesday, January 15 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 3

Speaker 3 of 9
Shiki Takamura, Kinki University Faculty of Medicine, Japan
CD69 Enhances the Recruitment of Memory CD8+ T Cells to the Lung Airways by Inhibiting S1P-Mediated Lymphocyte Egression from the Lung Parenchyma

Wednesday, January 15 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 3

Speaker 4 of 9
Shalini Sharma, St. Jude Children's Research Hospital, USA
mCMV Alters the Airway Inflammatory Milieu Regulating Protective and Pathogenic Heterologous Immunity to Influenza A Virus Infection

Wednesday, January 15 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 3

Speaker 5 of 9
Silvia Ariotti, Netherlands Cancer Institute, Netherlands
Induction of a Local Anti-Pathogen State by Tissue-Resident Memory CD8+ T Cells

Wednesday, January 15 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 3

Speaker 6 of 9
Carmen Gerlach, Karolinska Institutet, Sweden
Transitional Memory Cells (Ttm) – A Novel Subset of CD8+ Memory T Cells

Wednesday, January 15 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 3

Speaker 7 of 9
Chang Hoon Lee, Korea Research Institute of Chemical Technology, South Korea
Human CCR2+ MAIT Cells Demonstrate Efficient Transendothelial Migration that Depends on the Expression of Glycosyltransferases and Non-redundant Chemokine Receptors

Wednesday, January 15 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 3

Speaker 8 of 9
Charles L. Dulberger, University of Chicago, USA
The Molecular Basis for MAIT Cell Recognition of Microbial Antigens Bound to MR1

Wednesday, January 15 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 3

Speaker 9 of 9
Yujun Huang, La Jolla Institute for Allergy and Immunology, USA
Driving Pre-Existing Immunity at the Mucosal Borders of the Intestine

Wednesday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, January 15 | 5:00PM - 6:25PM
Site-Specific: Pulmonary
Room: Ballroom 3

Speaker 1 of 4
* David L. Woodland, Keystone Symposia on Molecular and Cellular Biology, USA

Wednesday, January 15 | 5:00PM - 6:25PM
Site-Specific: Pulmonary
Room: Ballroom 3

Speaker 2 of 4
Linda S. Cauley, University of Connecticut Health Center, USA
Protection by Tissue-Resident Memory CD8 T Cells in the Lungs

Wednesday, January 15 | 5:00PM - 6:25PM
Site-Specific: Pulmonary
Room: Ballroom 3

Speaker 3 of 4
Jie Liu, NIAID, National Institutes of Health, USA
Short Talk: Pre-Existing Subdominant CD8 T Effectors Control Respiratory Syncytial Virus Lung Infection with Limited Immunopathology

Wednesday, January 15 | 5:00PM - 6:25PM
Site-Specific: Pulmonary
Room: Ballroom 3

Speaker 4 of 4
Jacob E. Kohlmeier, Emory University, USA
Generation, Maintenance and Recall of Airway-Resident Memory T Cells

Wednesday, January 15 | 6:25PM - 7:00PM
Closing Remarks
Room: Ballroom 3

Speaker 1 of 1
Peter C. Doherty, University of Melbourne, Australia
Closing Remarks with Acknowledgement of Leo Lefrançois

Wednesday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 2


Wednesday, January 15 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2


Wednesday, January 15 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 1-2


Thursday, January 16 | 10:25AM - 10:25AM
Departure


*Session Chair.