Web Desc
Aging - Pushing the Limits of Cellular Quality Control
Organizer(s): Andrew G. Dillin, Daniel E. Gottschling and Thomas Nyström
Date: January 12 - 17, 2014
Location: Sheraton Steamboat Resort, Steamboat Springs, Colorado, USA
Supported by the Directors' Fund
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Summary of Meeting:
Aging is one of the highest risk factors known for most diseases of the modern era of humanity. Such age-related diseases are linked to the loss of performance of a large variety of homeostatic processes protecting the genome, proteome, lipidome or metabolome. One of the greatest challenges facing any organism is to coordinate the operation and maintenance of these different homeostatic processes and, in multicellular organisms, also to harmonize these functions across all cells and tissues. However, the highly interconnected nature of homeostatic machineries makes the system vulnerable to perturbations as the breakdown of one specific homeostatic process during aging or stress brings forth repercussions on other maintenance activities. In addition, as each cell or tissue must remain aware of the performance and wellbeing of distal cells and organelles, a breakdown in cell-to-cell and organelle-to-organelle communication can lead to critical macromolecular perturbations, including a loss of genome, proteome, lipidome, metabolome and endocrine functions leading to the inception of age-related disorders. The goal of this meeting is to bridge interdisciplinary approaches studying different aspects of cellular quality control and homeostasis with research on the aging soma and germline. We believe that deciphering the mechanisms of homeostatic control, its interconnective nature and homeostatic communication between cells and organelles may lead to a deeper understanding of the aging process – its onset, sequence of events and critical targets.
Scholarship Deadline: October 3 2013
Discounted Abstract Deadline: October 3 2013
Abstract Deadline: October 28 2013
Discounted Registration Deadline: November 13 2013
Abstacts when book is in proofing process


We gratefully acknowledge additional support for this conference from:
The Ellison Medical FoundationGlenn Foundation for Medical Research
MitoKyne
Proteostasis Therapeutics, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 12 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Monday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Foyer/Rainbow/Twilight


Monday, January 13 | 8:00AM - 11:00AM
Modern Bioenergetics. Session Sponsored by The Ellison Medi
cal Foundation.

Room: Storm Peak/Mt. Werner
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 1 of 6
* Carsten Merkwirth, Ferring Research Institute, Inc, USA

Monday, January 13 | 8:00AM - 11:00AM
Modern Bioenergetics. Session Sponsored by The Ellison Medi
cal Foundation.

Room: Storm Peak/Mt. Werner
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 2 of 6
Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
Mitonuclear Protein Balance as a Determinant of Health- and Lifespan

Monday, January 13 | 8:00AM - 11:00AM
Modern Bioenergetics. Session Sponsored by The Ellison Medi
cal Foundation.

Room: Storm Peak/Mt. Werner
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 3 of 6
Adam Antebi, Max Planck Institut für Biologie des Alterns, Germany
Enhanced Hexosamine Pathway Flux Extends Lifespan and Protects Against Proteotoxicity

Monday, January 13 | 8:00AM - 11:00AM
Modern Bioenergetics. Session Sponsored by The Ellison Medi
cal Foundation.

Room: Storm Peak/Mt. Werner
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 4 of 6
Benjamin Tu, University of Texas Southwestern Medical Center, USA
Master Metabolites and their Influence on Cell Proliferation and Survivability

Monday, January 13 | 8:00AM - 11:00AM
Modern Bioenergetics. Session Sponsored by The Ellison Medi
cal Foundation.

Room: Storm Peak/Mt. Werner
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 5 of 6
Sean P. Curran, University of Southern California, USA
Short Talk: Dietary Adaptation Is Mediated by Mitochondrial Homeostasis during Normal Aging

Monday, January 13 | 8:00AM - 11:00AM
Modern Bioenergetics. Session Sponsored by The Ellison Medi
cal Foundation.

Room: Storm Peak/Mt. Werner
Support for these organizer-selected speakers generously provided by this foundation.
Speaker 6 of 6
William B. Mair, Harvard School of Public Health, USA
Short Talk: Communicating Longevity Neuro-Endocrine Regulation of Longevity by cric-1

Monday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, January 13 | 11:00AM - 2:30PM
On Own for Lunch and Recreation


Monday, January 13 | 11:15AM - 1:00PM
Poster Setup
Room: Sunshine


Monday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine


Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Emerging Concepts
Room: Storm Peak/Mt. Werner

Speaker 1 of 6
* Kristan K. Steffen, University of California, Berkeley, USA

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Emerging Concepts
Room: Storm Peak/Mt. Werner

Speaker 2 of 6
Dana M. Alessi Wolken, Columbia University, USA
Mitochondrial Remodeling through the Proteasome Is Critical for Mitochondrial Quality Control

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Emerging Concepts
Room: Storm Peak/Mt. Werner

Speaker 3 of 6
Collin Y. Ewald, Joslin Diabetes Center, USA
Dauer-Independent Insulin/IGF-1 Signaling Implicates Collagens in Longevity

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Emerging Concepts
Room: Storm Peak/Mt. Werner

Speaker 4 of 6
Supriya Srinivasan, The Scripps Research Institute, USA
Neuroendocrine Control of Energy Regulation in C. elegans

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Emerging Concepts
Room: Storm Peak/Mt. Werner

Speaker 5 of 6
Scott Kennedy, University of Washington, USA
Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations that Are Inconsistent with Oxidative Damage

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Emerging Concepts
Room: Storm Peak/Mt. Werner

Speaker 6 of 6
Ruth Kroschewski, Swiss Federal Institute of Technology, Switzerland
Asymmetric Segregation of Bacterial Plasmid DNA in Mammalian Cells

Monday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, January 13 | 5:00PM - 7:00PM
Spatial Quality Control
Room: Storm Peak/Mt. Werner

Speaker 1 of 5
* Nathan Baird, University of California, Berkeley, USA

Monday, January 13 | 5:00PM - 7:00PM
Spatial Quality Control
Room: Storm Peak/Mt. Werner

Speaker 2 of 5
Thomas Nyström, Göteborg University, Sweden
Factors Required for the Recognition, Partitioning, and Asymmetrical Inheritance of Protein Aggregates

Monday, January 13 | 5:00PM - 7:00PM
Spatial Quality Control
Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Judith Frydman, Stanford University, USA
Pathways of Quality Control: Protein Folding and Misfolding in the Eukaryotic Cytosol

Monday, January 13 | 5:00PM - 7:00PM
Spatial Quality Control
Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Joris Winderickx, KU Leuven, Belgium
Role of Vesicular Trafficking in Management of Folding Disease Proteins

Monday, January 13 | 5:00PM - 7:00PM
Spatial Quality Control
Room: Storm Peak/Mt. Werner

Speaker 5 of 5
Jeffrey S. Smith, University of Virginia School of Medicine, USA
Short Talk: Contributions of Histone Acetyltransferase Complexes SAGA and SLIK to Yeast Chronological Life span During Caloric Restriction

Monday, January 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sunshine


Monday, January 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunshine


Tuesday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Foyer/Rainbow/Twilight


Tuesday, January 14 | 8:00AM - 11:00AM
Mitochondrial Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 1 of 6
* Nathaniel Thayer, Fred Hutchinson Cancer Research Center, USA

Tuesday, January 14 | 8:00AM - 11:00AM
Mitochondrial Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 2 of 6
Cole M. Haynes, University of Massachusetts Medical School, USA
Repairing and Regenerating Defective Mitochondria during the UPRmt

Tuesday, January 14 | 8:00AM - 11:00AM
Mitochondrial Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 3 of 6
Jodi Nunnari, University of California, Davis, USA
The Behavior of Mitochondria

Tuesday, January 14 | 8:00AM - 11:00AM
Mitochondrial Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 4 of 6
Thomas Langer, CECAD Research Center, Germany
Proteolytic Control of Mitochondrial Dynamics

Tuesday, January 14 | 8:00AM - 11:00AM
Mitochondrial Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 5 of 6
Norbert Perrimon, Harvard Medical School, USA
Regulation of the Aging Process Pathways Involved in Organ Communication

Tuesday, January 14 | 8:00AM - 11:00AM
Mitochondrial Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 6 of 6
Ryo Higuchi, Columbia University, USA
Short Talk: Role for Actin Dynamics in Mitochondrial Quality Control and Lifespan in Budding Yeast

Tuesday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, January 14 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine


Tuesday, January 14 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine


Tuesday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, January 14 | 5:00PM - 7:15PM
Evolution of Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 1 of 6
* David Öling, Gothenburg University, Sweden

Tuesday, January 14 | 5:00PM - 7:15PM
Evolution of Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 2 of 6
Thomas Kirkwood, Newcastle University, UK
The Evolvability of Stress Responses

Tuesday, January 14 | 5:00PM - 7:15PM
Evolution of Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 3 of 6
Daniel E.L. Promislow, University of Washington, USA
Homeostasis and the Aging Network: An Interspecific Perspective

Tuesday, January 14 | 5:00PM - 7:15PM
Evolution of Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 4 of 6
Adam Frost, University of California, San Francisco, USA
Functional Repurposing of Proteins through Evolution: How Organelle Homeostasis Mechanisms Vary between Species

Tuesday, January 14 | 5:00PM - 7:15PM
Evolution of Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 5 of 6
Patrick C. Phillips, University of Oregon, USA
Short Talk: Using Experimental Evolution to Study the Molecular Quantitative Genomics of Stress Resistance and Longevity in the Nematode Caenorhabditis remanei

Tuesday, January 14 | 5:00PM - 7:15PM
Evolution of Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 6 of 6
Bjoern Schumacher, University of Cologne, Germany
Short Talk: Activation of Somatic Proteostasis Confers Systemic Stress Resistance in Response to Genome Instability in Germ Cells

Tuesday, January 14 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Sunshine


Tuesday, January 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunshine


Wednesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Foyer/Rainbow/Twilight


Wednesday, January 15 | 8:00AM - 11:00AM
Lipid/Membrane Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 1 of 5
* Kiersten Amie Henderson, Fred Hutchinson Cancer Research Center, USA

Wednesday, January 15 | 8:00AM - 11:00AM
Lipid/Membrane Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 2 of 5
Miriam Greenberg, Wayne State University, USA
The Central Role of the Mitochondrial Phospholipid Cardiolipin in Cellular Functions

Wednesday, January 15 | 8:00AM - 11:00AM
Lipid/Membrane Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Lois S. Weisman, University of Michigan, USA
Phosphatidylinositol 3,5-Bisphosphate, Membrane Trafficking, Metabolism and Disease

Wednesday, January 15 | 8:00AM - 11:00AM
Lipid/Membrane Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Malene Hansen, Sanford Burnham Prebys Medical Discovery Institute, USA
Understanding the Role of Autophagy in C. elegans Aging

Wednesday, January 15 | 8:00AM - 11:00AM
Lipid/Membrane Homeostasis
Room: Storm Peak/Mt. Werner

Speaker 5 of 5
Brandon H. Toyama, The Salk Institute, USA
Short Talk: Maintenance of Proteins with Exceptional Longevity through Aging

Wednesday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, January 15 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine


Wednesday, January 15 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Wednesday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine


Wednesday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, January 15 | 5:00PM - 7:30PM
Proteostasis
Room: Storm Peak/Mt. Werner

Speaker 1 of 6
* Peter M. Douglas, University of California, Berkeley, USA

Wednesday, January 15 | 5:00PM - 7:30PM
Proteostasis
Room: Storm Peak/Mt. Werner

Speaker 2 of 6
Richard I. Morimoto, Northwestern University, USA
Proteostasis Network Collapse in C. elegans Aging

Wednesday, January 15 | 5:00PM - 7:30PM
Proteostasis
Room: Storm Peak/Mt. Werner

Speaker 3 of 6
Jonathan S. Weissman, University of California, San Francisco, USA
Monitoring Protein Synthesis One Codon at a Time through Ribosome Profiling

Wednesday, January 15 | 5:00PM - 7:30PM
Proteostasis
Room: Storm Peak/Mt. Werner

Speaker 4 of 6
Bernd Bukau, Universität Heidelberg, Germany
Cellular Strategies for Coping with Protein Aggregation

Wednesday, January 15 | 5:00PM - 7:30PM
Proteostasis
Room: Storm Peak/Mt. Werner

Speaker 5 of 6
F. Ulrich Hartl, Max Planck Institute of Biochemistry, Germany
Toxic Protein Aggregation and the Cellular Defense Against It

Wednesday, January 15 | 5:00PM - 7:30PM
Proteostasis
Room: Storm Peak/Mt. Werner

Speaker 6 of 6
Thorsten Hoppe, University of Cologne, Germany
Short Talk: A Novel Mitochondrial Surveillance Response Orchestrates Ubiquitin-Dependent Proteolysis

Wednesday, January 15 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Sunshine


Wednesday, January 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunshine


Thursday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Foyer/Rainbow/Twilight


Thursday, January 16 | 8:00AM - 11:00AM
Inter-Organelle Dynamics
Room: Storm Peak/Mt. Werner

Speaker 1 of 5
* Vidhya Ramachandran, University of California, Berkeley, USA

Thursday, January 16 | 8:00AM - 11:00AM
Inter-Organelle Dynamics
Room: Storm Peak/Mt. Werner

Speaker 2 of 5
Gerald S. Shadel, The Salk Institute for Biological Studies, USA
Mitochondrial-Stress Signaling Regulates Nuclear Gene Expression and Longevity

Thursday, January 16 | 8:00AM - 11:00AM
Inter-Organelle Dynamics
Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Dan Gottschling, Calico, USA
Organelle Deterioration with Age: The Limits of an Interconnected Cellular System

Thursday, January 16 | 8:00AM - 11:00AM
Inter-Organelle Dynamics
Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Scott D. Emr, Cornell University, USA
Plasma Membrane Protein Quality Control: Essential Role for Ubiquitin Ligase Adaptor Network

Thursday, January 16 | 8:00AM - 11:00AM
Inter-Organelle Dynamics
Room: Storm Peak/Mt. Werner

Speaker 5 of 5
Amrita Mangalvedhekar Nargund, Sloan-Kettering Institute for Cancer Research, USA
Short Talk: ATFS-1 Coordinates Nuclear and Mitochondrial Transcription to Restore Respiratory Capacity during Stress

Thursday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, January 16 | 11:00AM - 2:30PM
On Own for Lunch and Recreation


Thursday, January 16 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts II
Room: Storm Peak/Mt. Werner

Speaker 1 of 6
* Sandra Malmgren Hill, Gothenburg University, Sweden

Thursday, January 16 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts II
Room: Storm Peak/Mt. Werner

Speaker 2 of 6
Daniel Kaganovich, Hebrew University of Jerusalem, Israel
The Role of Inclusions, Cytoskeleton and Stress Foci in Spatial Quality Control

Thursday, January 16 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts II
Room: Storm Peak/Mt. Werner

Speaker 3 of 6
Prasad Kasturi, Max Planck Institute for Biochemistry, Germany
Age-Related Remodeling of the Proteostasis Network in C. elegans Revealed by Quantitative Proteomics

Thursday, January 16 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts II
Room: Storm Peak/Mt. Werner

Speaker 4 of 6
Koichi Iijima, National Center for Geriatrics and Gerontology, Japan
Epigenetic Modifications Reveal the Minimal Unit of UPR that Promotes ERAD and Protects against Age-Related Chronic Proteinopathy in the Brain

Thursday, January 16 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts II
Room: Storm Peak/Mt. Werner

Speaker 5 of 6
Thibault Mayor, University of British Columbia, Canada
The Rsp5 Ubiquitin Ligase Targets Cytosolic Misfolded Proteins for Proteasome Degradation

Thursday, January 16 | 2:30PM - 4:30PM
Workshop 2: Emerging Concepts II
Room: Storm Peak/Mt. Werner

Speaker 6 of 6
Warakorn Kulalert, Massachusetts Institute of Technology, USA
Cell Non-Autonomous Effects of Neuronal ER Stress on Larval Development in C. elegans

Thursday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, January 16 | 5:00PM - 7:30PM
Novel Strategies for Germ and Stem Cell Quality Control
Room: Storm Peak/Mt. Werner

Speaker 1 of 6
* Sarah Hanzén, Gothenburg University, Sweden

Thursday, January 16 | 5:00PM - 7:30PM
Novel Strategies for Germ and Stem Cell Quality Control
Room: Storm Peak/Mt. Werner

Speaker 2 of 6
Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Hematopoietic Stem Cells Require a Highly Regulated Rate of Protein Synthesis

Thursday, January 16 | 5:00PM - 7:30PM
Novel Strategies for Germ and Stem Cell Quality Control
Room: Storm Peak/Mt. Werner

Speaker 3 of 6
Yves P. Barral, ETH Zürich, Switzerland
Lateral Diffusion Barriers and the Segregation of Aging Factors during Mitosis

Thursday, January 16 | 5:00PM - 7:30PM
Novel Strategies for Germ and Stem Cell Quality Control
Room: Storm Peak/Mt. Werner

Speaker 4 of 6
Mary-Rose Bufalino, University of Toronto, Canada
The Asymmetric Division of Damaged Proteins Is Stem Cell-Type Dependent and Influences Cell Fate

Thursday, January 16 | 5:00PM - 7:30PM
Novel Strategies for Germ and Stem Cell Quality Control
Room: Storm Peak/Mt. Werner

Speaker 5 of 6
Pekka Katajisto, University of Helsinki, Finland
Short Talk: Asymmetric Apportioning of Aged Mitochondria between Daughter Cells

Thursday, January 16 | 5:00PM - 7:30PM
Novel Strategies for Germ and Stem Cell Quality Control
Room: Storm Peak/Mt. Werner

Speaker 6 of 6
Andrew G. Dillin, University of California, Berkeley, USA
Proteostasis of Germ and Stem Cells

Thursday, January 16 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Sunshine


Thursday, January 16 | 8:00PM - 11:00PM
Entertainment
Room: Sunshine


Thursday, January 16 | 8:00PM - 11:00PM
Cash Bar
Room: Sunshine


Friday, January 17 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.