Web Desc
New Frontiers in the Discovery and Treatment of Thrombosis
Organizer(s): Jane E. Freedman, Bruce Furie and Dietmar Seiffert
Date: January 26 - 30, 2014
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Bayer HealthCare Pharmaceuticals
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Summary of Meeting:
During the last several decades, there has been unprecedented growth in the fundamental understanding of coagulation and platelet function. The logical evolution of these discoveries has been the development of a wide array of therapies targeting platelet receptors and pathways within coagulation to treat thrombotic diseases. Although clearly successful, the evolution of these agents is at a crossroads due to limitations and questions including hemorrhage and pleiotropic effects. The goal of this symposium is to explore new discoveries in thrombosis and consider their potential for translation relative to existing/developing therapies. This symposium will focus on: 1) Understanding how fundamental mechanisms regulating vascular disease risk factors and genetics modulate coagulation; 2) Investigating how these processes influence platelet-dependent thrombosis and vessel wall interactions; and 3) Determining how the evolution of treatments for thrombosis has led to a new appreciation of the complex interactions between coagulation and thrombosis, and how this may guide the use of new and existing therapies. This meeting will bridge clinical and basic investigators to discuss a rapidly evolving field. The goal is to gain a greater appreciation of the novel discoveries in the areas of vascular occlusion, the treatment of thrombosis and the minimization of risk.
Scholarship Deadline: October 9 2013
Discounted Abstract Deadline: October 9 2013
Abstract Deadline: October 31 2013
Discounted Registration Deadline: November 25 2013
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer HealthCare Pharmaceuticals
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Pfizer Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL120495-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 26 | 4:00PM - 8:00PM
Arrival and Registration
Room: Keystone Lodge Foyer


Monday, January 27 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Monday, January 27 | 8:00AM - 9:00AM
Keynote Address
Room: Grays Peak I-II

Speaker 1 of 2
* Jane E. Freedman, University of Massachusetts Medical School, USA

Monday, January 27 | 8:00AM - 9:00AM
Keynote Address
Room: Grays Peak I-II

Speaker 2 of 2
Andrew S. Weyrich, University of Utah School of Medicine, USA
Platelets: More Than We Ever Expected

Monday, January 27 | 9:00AM - 11:15AM
Genomics and Transcriptomics in Thrombosis and Coagulation
Room: Grays Peak I-II

Speaker 1 of 4
* Bruce Furie, Beth Israel Deaconess Medical Center, USA

Monday, January 27 | 9:00AM - 11:15AM
Genomics and Transcriptomics in Thrombosis and Coagulation
Room: Grays Peak I-II

Speaker 2 of 4
Jane E. Freedman, University of Massachusetts Medical School, USA
Platelet Transcripts, Genetics and Function

Monday, January 27 | 9:00AM - 11:15AM
Genomics and Transcriptomics in Thrombosis and Coagulation
Room: Grays Peak I-II

Speaker 3 of 4
Marc Sabatine, Brigham and Women's Hospital, USA
Pharmacogenetics of Antithrombotic Therapy

Monday, January 27 | 9:00AM - 11:15AM
Genomics and Transcriptomics in Thrombosis and Coagulation
Room: Grays Peak I-II

Speaker 4 of 4
Willem H. Ouwehand, University of Cambridge, UK
Genetic Regulation of Megakaryopoiesis and Platelet Formation

Monday, January 27 | 9:40AM - 10:00AM
Coffee Break
Room: Longs Peak Foyer


Monday, January 27 | 11:15AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Monday, January 27 | 11:15AM - 2:30PM
On Own for Lunch and Recreation


Monday, January 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Monday, January 27 | 2:30PM - 4:30PM
Workshop: Thrombosis, Inflammation and Infection
Room: Grays Peak I-II

Speaker 1 of 7
* Leslie V. Parise, University of North Carolina School of Medicine, USA

Monday, January 27 | 2:30PM - 4:30PM
Workshop: Thrombosis, Inflammation and Infection
Room: Grays Peak I-II

Speaker 2 of 7
Jamey D. Marth, Sanford-Burnham Medical Research Institute, USA
Inducing Anti-Thrombotic Host Protection in Pneumococcal Sepsis by Pre-Activation of the Ashwell-Morell Receptor

Monday, January 27 | 2:30PM - 4:30PM
Workshop: Thrombosis, Inflammation and Infection
Room: Grays Peak I-II

Speaker 3 of 7
Sang Hee Min, University of Pennsylvania, USA
Loss of PIKfyve in Platelets Causes a Lysosomal Disease Leading to Inflammation and Thrombosis in Mice

Monday, January 27 | 2:30PM - 4:30PM
Workshop: Thrombosis, Inflammation and Infection
Room: Grays Peak I-II

Speaker 4 of 7
Craig Morrell, University of Rochester School of Medicine, USA
Platelet Factor 4 Limits T-Helper 17 Differentiation and Responses to Cardiac Transplantation

Monday, January 27 | 2:30PM - 4:30PM
Workshop: Thrombosis, Inflammation and Infection
Room: Grays Peak I-II

Speaker 5 of 7
Travis R. Sexton, University of Kentucky, USA
The Effect of Rosuvastatin on Platelet-Leukocyte Interactions in the Setting of Acute Myocardial Infarction

Monday, January 27 | 2:30PM - 4:30PM
Workshop: Thrombosis, Inflammation and Infection
Room: Grays Peak I-II

Speaker 6 of 7
Norah Green Verbout, Oregon Health & Science University, USA
Pharmacological Protein C Activation Improves the Neurological Outcome of Experimental Autoimmune Encephalomyelitis in Mice

Monday, January 27 | 2:30PM - 4:30PM
Workshop: Thrombosis, Inflammation and Infection
Room: Grays Peak I-II

Speaker 7 of 7
Fusun Kilic, Merced College, USA
A Serotonin-Induced N-Glycan Switch Regulates Platelet Aggregation

Monday, January 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 27 | 5:00PM - 7:00PM
Breakthroughs in Coagulation
Room: Grays Peak I-II

Speaker 1 of 5
* Gianluca Interlandi, University of Washington, USA

Monday, January 27 | 5:00PM - 7:00PM
Breakthroughs in Coagulation
Room: Grays Peak I-II

Speaker 2 of 5
Nigel Mackman, University of North Carolina at Chapel Hill, USA
Novel Mechanisms Regulating Coagulation and Thrombosis

Monday, January 27 | 5:00PM - 7:00PM
Breakthroughs in Coagulation
Room: Grays Peak I-II

Speaker 3 of 5
Wolfgang Bergmeier, University of North Carolina at Chapel Hill, USA
Short Talk: The Rap-GAP Rasa3 Is a Critical Negative Regulator of Platelet Activation

Monday, January 27 | 5:00PM - 7:00PM
Breakthroughs in Coagulation
Room: Grays Peak I-II

Speaker 4 of 5
Bruce Furie, Beth Israel Deaconess Medical Center, USA
Protein Disulfide Isomerases: Novel Targets for Novel Antithrombotics

Monday, January 27 | 5:00PM - 7:00PM
Breakthroughs in Coagulation
Room: Grays Peak I-II

Speaker 5 of 5
Jeffrey Weitz, McMaster University, Canada
Evolving Use and Limitations of New Oral Anticoagulants

Monday, January 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Monday, January 27 | 7:30PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Tuesday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Tuesday, January 28 | 8:00AM - 11:00AM
Thrombotic Interactions with the Vessel Wall
Room: Grays Peak I-II

Speaker 1 of 6
* Dong-Eog Kim, Dongguk University Ilsan Hospital, South Korea

Tuesday, January 28 | 8:00AM - 11:00AM
Thrombotic Interactions with the Vessel Wall
Room: Grays Peak I-II

Speaker 2 of 6
Mortimer Poncz, Children's Hospital of Philadelphia, USA
Platelet-Targeted Thromboprophylactic: Lessons from Quebec Platelet Disorder

Tuesday, January 28 | 8:00AM - 11:00AM
Thrombotic Interactions with the Vessel Wall
Room: Grays Peak I-II

Speaker 3 of 6
Shirin Feghhi, University of Washington, USA
Short Talk: GPIb-IX-V Complex Transmits Platelet Contractile Forces

Tuesday, January 28 | 8:00AM - 11:00AM
Thrombotic Interactions with the Vessel Wall
Room: Grays Peak I-II

Speaker 4 of 6
Kohji Kasahara, Tokyo Metropolitan Institute of Medical Science, Japan
Short Talk: Clot Retraction Is Mediated by Factor XIII-Dependent Fibrin-alphaIIbbeta3-Myosin Axis in Platelet Sphingomyelin-Rich Membrane Rafts

Tuesday, January 28 | 8:00AM - 11:00AM
Thrombotic Interactions with the Vessel Wall
Room: Grays Peak I-II

Speaker 5 of 6
Steven R. Lentz, University of Iowa, USA
Antithrombotic Gene Regulation in the Vessel Wall

Tuesday, January 28 | 8:00AM - 11:00AM
Thrombotic Interactions with the Vessel Wall
Room: Grays Peak I-II

Speaker 6 of 6
Lawrence F. Brass, University of Pennsylvania, USA
Spatial and Structural Determinants of Thrombus Growth and Stability

Tuesday, January 28 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, January 28 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Tuesday, January 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 28 | 5:00PM - 7:00PM
New, Evolving Use of Antithrombotic and Antiplatelet Therapi
es

Room: Grays Peak I-II

Speaker 1 of 5
* Dietmar Seiffert, Merck, USA

Tuesday, January 28 | 5:00PM - 7:00PM
New, Evolving Use of Antithrombotic and Antiplatelet Therapi
es

Room: Grays Peak I-II

Speaker 2 of 5
Joseph Italiano, Brigham and Women's Hospital, USA
Platelet Production On-a-Chip

Tuesday, January 28 | 5:00PM - 7:00PM
New, Evolving Use of Antithrombotic and Antiplatelet Therapi
es

Room: Grays Peak I-II

Speaker 3 of 5
Alan D. Michelson, Harvard Medical School, USA
Clopidogrel Pharmacokinetics and Pharmacodynamics

Tuesday, January 28 | 5:00PM - 7:00PM
New, Evolving Use of Antithrombotic and Antiplatelet Therapi
es

Room: Grays Peak I-II

Speaker 4 of 5
Erik Tucker, Aronora, Inc, USA
Short Talk: The Protein C Activator Enzyme EWE-Thrombin Rapidly Interrupts Occlusive Thrombus Formation in Primates

Tuesday, January 28 | 5:00PM - 7:00PM
New, Evolving Use of Antithrombotic and Antiplatelet Therapi
es

Room: Grays Peak I-II

Speaker 5 of 5
Francesco Violi, Università di Roma, Italy
Oxidative Stress, Platelets and Thrombosis

Tuesday, January 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Tuesday, January 28 | 7:30PM - 10:00PM
Poster Session 2
Room: Shavano/Torreys


Wednesday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Wednesday, January 29 | 8:00AM - 11:15AM
Antithrombotics: Balancing Hemorrhage, Off-Target Effects an
d Utility

Room: Grays Peak I-II

Speaker 1 of 7
* Debra D. Pittman, Pfizer, USA

Wednesday, January 29 | 8:00AM - 11:15AM
Antithrombotics: Balancing Hemorrhage, Off-Target Effects an
d Utility

Room: Grays Peak I-II

Speaker 2 of 7
Tilo Grosser, University of Pennsylvania, USA
Prostanoids and Thrombosis

Wednesday, January 29 | 8:00AM - 11:15AM
Antithrombotics: Balancing Hemorrhage, Off-Target Effects an
d Utility

Room: Grays Peak I-II

Speaker 3 of 7
Joachim Fruebis, BlueRock Therapeutics, USA
Novel Therapeutic Approaches in Hemophilia and Hematology

Wednesday, January 29 | 8:00AM - 11:15AM
Antithrombotics: Balancing Hemorrhage, Off-Target Effects an
d Utility

Room: Grays Peak I-II

Speaker 4 of 7
Scott L. Diamond, University of Pennsylvania, USA
Short Talk: Microfluidic Phenotyping of in vivo Aspirin Response of Normal Donors or Clotting Response of Blood from Hemophiliacs

Wednesday, January 29 | 8:00AM - 11:15AM
Antithrombotics: Balancing Hemorrhage, Off-Target Effects an
d Utility

Room: Grays Peak I-II

Speaker 5 of 7
Timothy J. Stalker, University of Pennsylvania, USA
Short Talk: Alpha2b-beta3 Outside-In Signaling Regulates Thrombus Formation in vivo via Effects on Intrathrombus Architecture and Solute Transport

Wednesday, January 29 | 8:00AM - 11:15AM
Antithrombotics: Balancing Hemorrhage, Off-Target Effects an
d Utility

Room: Grays Peak I-II

Speaker 6 of 7
Kenneth W. Mahaffey, Stanford University, USA
Antithrombotic Development Challenges for Acute Coronary Syndromes

Wednesday, January 29 | 8:00AM - 11:15AM
Antithrombotics: Balancing Hemorrhage, Off-Target Effects an
d Utility

Room: Grays Peak I-II

Speaker 7 of 7
Richard C. Becker, University of Cincinnati, USA
Antithrombotics: Balancing Hemorrhage, Off-Target Effects and Utility Beyond Aggregation-New Areas to Understand Efficacy and Bleeding

Wednesday, January 29 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, January 29 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Wednesday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 29 | 5:00PM - 7:00PM
Thrombosis and Inflammation
Room: Grays Peak I-II

Speaker 1 of 5
* Lea M. Beaulieu, Platelet BioGenesis, USA

Wednesday, January 29 | 5:00PM - 7:00PM
Thrombosis and Inflammation
Room: Grays Peak I-II

Speaker 2 of 5
Susan S. Smyth, University of Kentucky Chandler Medical Center, USA
Thrombosis and Inflammation

Wednesday, January 29 | 5:00PM - 7:00PM
Thrombosis and Inflammation
Room: Grays Peak I-II

Speaker 3 of 5
Christian Gachet, INSERM, University of Strasbourg, EFS-Alsace, France
Purinergic Signalling, Thrombosis and inflammation

Wednesday, January 29 | 5:00PM - 7:00PM
Thrombosis and Inflammation
Room: Grays Peak I-II

Speaker 4 of 5
Laura D. Healy, Oregon Health & Science University, USA
Short Talk: Contact Activation Supports the Prothrombotic Effect of Neutrophil Extracellular Traps (NETs)

Wednesday, January 29 | 5:00PM - 7:00PM
Thrombosis and Inflammation
Room: Grays Peak I-II

Speaker 5 of 5
Leslie V. Parise, University of North Carolina School of Medicine, USA
Systems Approach to Platelet Biology

Wednesday, January 29 | 7:00PM - 7:15PM
Closing Remarks
Room: Grays Peak I-II

Speaker 1 of 1
Jane E. Freedman, University of Massachusetts Medical School, USA

Wednesday, January 29 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Wednesday, January 29 | 8:00PM - 11:00PM
Entertainment
Room: Shavano/Torreys


Wednesday, January 29 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Thursday, January 30 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.