Web Desc
Growth and Wasting in Heart and Skeletal Muscle
Organizer(s): Elizabeth M. McNally, Nadia A. Rosenthal and Leslie A. Leinwand
Date: January 26 - 31, 2014
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Sponsored by Bayer HealthCare Pharmaceuticals
For important information on the coronavirus, please click here
Summary of Meeting:
Maintenance of cardiac and skeletal muscle mass and function is central to well-being in aging and illness. Striated muscles, including cardiac and skeletal muscles, increase in size and mass in response to exercise, nutritional status, pregnancy and other concomitant energy demand states. The mass of cardiac and skeletal muscle declines in response to sepsis, cancer, aging and immobility. A confluence of metabolic and genetic factors regulates muscle mass, and both cardiac and skeletal muscle each have significant paracrine actions for growth beyond heart and muscle. This unique meeting highlights mechanisms and targets for both cardiac and skeletal muscle growth, emphasizing novel pathways and new applications.
Scholarship Deadline: October 10 2013
Discounted Abstract Deadline: October 10 2013
Abstract Deadline: November 4 2013
Discounted Registration Deadline: November 26 2013
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer HealthCare Pharmaceuticals
We gratefully acknowledge additional support for this conference from:
Cellular Dynamics InternationalCytokinetics, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
S. Karger AG - Cardiology
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Grant No. 1R13AR065744-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 26 | 4:00PM - 8:00PM
Arrival and Registration
Room: Zia Concourse


Monday, January 27 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Monday, January 27 | 8:00AM - 9:00AM
Keynote Address
Room: Anasazi Ballroom

Speaker 1 of 2
* Leslie A. Leinwand, University of Colorado Boulder, USA
Opening Remarks

Monday, January 27 | 8:00AM - 9:00AM
Keynote Address
Room: Anasazi Ballroom

Speaker 2 of 2
Eric N. Olson, University of Texas Southwestern Medical Center, USA
New Myogenic Regulatory Molecules and Mechanisms

Monday, January 27 | 9:00AM - 11:15AM
Atrophy Signaling Pathways
Room: Anasazi Ballroom

Speaker 1 of 5
* Issei Komuro, Tokyo University Graduate School, Japan

Monday, January 27 | 9:00AM - 11:15AM
Atrophy Signaling Pathways
Room: Anasazi Ballroom

Speaker 2 of 5
Marco Sandri, University of Padova, Italy
FoxO, Autophagy and Ubiquitin Proteasome: The Crossroad of Muscle Mass Regulation

Monday, January 27 | 9:00AM - 11:15AM
Atrophy Signaling Pathways
Room: Anasazi Ballroom

Speaker 3 of 5
Sue Bodine, University of Iowa, USA
MuRF1 and the Regulation of Skeletal Muscle Mass

Monday, January 27 | 9:00AM - 11:15AM
Atrophy Signaling Pathways
Room: Anasazi Ballroom

Speaker 4 of 5
Kenneth Walsh, University of Virginia School of Medicine, USA
Parallel Mechanisms of Cardiac and Skeletal Muscle Growth: Lessons from Akt Signaling

Monday, January 27 | 9:00AM - 11:15AM
Atrophy Signaling Pathways
Room: Anasazi Ballroom

Speaker 5 of 5
Jose M. Garcia, Baylor College of Medicine, USA
Short Talk: Ghrelin Prevents Cancer-Related Muscle Wasting through GHSR-Independent Regulation of Myostatin and p38

Monday, January 27 | 9:40AM - 10:00AM
Coffee Break
Room: Zia Concourse


Monday, January 27 | 11:15AM - 1:00PM
Poster Setup
Room: Sunset Room/Eldorado Court


Monday, January 27 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Monday, January 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room/Eldorado Court


Monday, January 27 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Monday, January 27 | 5:00PM - 7:00PM
Growth Factors for Heart and Muscle
Room: Anasazi Ballroom

Speaker 1 of 5
* Denis C. Guttridge, Ohio State University, USA

Monday, January 27 | 5:00PM - 7:00PM
Growth Factors for Heart and Muscle
Room: Anasazi Ballroom

Speaker 2 of 5
Deepak Srivastava, Gladstone Institutes, USA
Reprogramming Approaches for Cardiovascular Disease

Monday, January 27 | 5:00PM - 7:00PM
Growth Factors for Heart and Muscle
Room: Anasazi Ballroom

Speaker 3 of 5
H.Q. Han, Amgen Inc., USA
Activation of Activin-Smad Signaling Leads to Atrophy and Dysfunction of the Heart

Monday, January 27 | 5:00PM - 7:00PM
Growth Factors for Heart and Muscle
Room: Anasazi Ballroom

Speaker 4 of 5
Nadia A. Rosenthal, The Jackson Laboratory, USA
Immune Regulation of Muscle Regeneration

Monday, January 27 | 5:00PM - 7:00PM
Growth Factors for Heart and Muscle
Room: Anasazi Ballroom

Speaker 5 of 5
Federica Accornero, Cincinnati Children's Medical Center, USA
Short Talk: TGF-beta Inhibits Skeletal Muscle Regeneration by Antagonizing Metallothioneins Induction

Monday, January 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Monday, January 27 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunset Room/Eldorado Court


Tuesday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Tuesday, January 28 | 7:30AM - 8:00AM
Poster Setup
Room: Sunset Room/Eldorado Court


Tuesday, January 28 | 8:00AM - 7:00PM
Poster Viewing
Room: Sunset Room/Eldorado Court


Tuesday, January 28 | 8:00AM - 11:00AM
Paracrine Mechanisms
Room: Anasazi Ballroom

Speaker 1 of 7
* Timothy A. McKinsey, University of Colorado Denver, USA

Tuesday, January 28 | 8:00AM - 11:00AM
Paracrine Mechanisms
Room: Anasazi Ballroom

Speaker 2 of 7
Zoltan P. Arany, University of Pennsylvania, USA
Peripartum Mechanisms of Heart Growth and Disease

Tuesday, January 28 | 8:00AM - 11:00AM
Paracrine Mechanisms
Room: Anasazi Ballroom

Speaker 3 of 7
Leslie A. Leinwand, University of Colorado Boulder, USA
Postprandial Heart Growth in Pythons

Tuesday, January 28 | 8:00AM - 11:00AM
Paracrine Mechanisms
Room: Anasazi Ballroom

Speaker 4 of 7
Lynn A. Megeney, Ottawa Hospital Research Institute, Canada
Intrinsic-Mediated Caspase Activation Is Essential for Cardiomyocyte Hypertrophy

Tuesday, January 28 | 8:00AM - 11:00AM
Paracrine Mechanisms
Room: Anasazi Ballroom

Speaker 5 of 7
Lily C. Chao, Children's Hospital Los Angeles, USA
Short Talk: NR4A1 – A Novel Regulator of Muscle Mass

Tuesday, January 28 | 8:00AM - 11:00AM
Paracrine Mechanisms
Room: Anasazi Ballroom

Speaker 6 of 7
Samuel Cadena, Novartis Institutes for BioMedical Research, USA
Short Talk: GPRC5b: A Potent Regulator of Skeletal Muscle Growth with Potential Role in Muscle Regeneration

Tuesday, January 28 | 8:00AM - 11:00AM
Paracrine Mechanisms
Room: Anasazi Ballroom

Speaker 7 of 7
Anna Foryst-Ludwig, CCR, Charite-Berlin, Germany
Short Talk: Specific Set of Plasma FFAs Mediates Cardiac Hypertrophic Response to Exercise

Tuesday, January 28 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Tuesday, January 28 | 11:15AM - 12:00PM
Lunch
Room: Sunset Room/Eldorado Court


Tuesday, January 28 | 12:00PM - 2:30PM
Poster Session 2
Room: Sunset Room/Eldorado Court


Tuesday, January 28 | 2:30PM - 3:00PM
Coffee Available
Room: Zia Concourse


Tuesday, January 28 | 3:00PM - 5:00PM
Genetic and Epigenetic Regulation
Room: Anasazi Ballroom

Speaker 1 of 5
* Lynn A. Megeney, Ottawa Hospital Research Institute, Canada

Tuesday, January 28 | 3:00PM - 5:00PM
Genetic and Epigenetic Regulation
Room: Anasazi Ballroom

Speaker 2 of 5
Saptarsi M. Haldar, University of California, San Francisco, USA
Targeting Chromatin-Dependent Signaling in Pathologic Cardiac Hypertrophy and Heart Failure

Tuesday, January 28 | 3:00PM - 5:00PM
Genetic and Epigenetic Regulation
Room: Anasazi Ballroom

Speaker 3 of 5
Timothy A. McKinsey, University of Colorado Denver, USA
HDACs in Cardiomyocyte Growth and Dysfunction

Tuesday, January 28 | 3:00PM - 5:00PM
Genetic and Epigenetic Regulation
Room: Anasazi Ballroom

Speaker 4 of 5
Eva van Rooij, Hubrecht Institute, Netherlands
MicroRNAs as Regulators of Growth

Tuesday, January 28 | 3:00PM - 5:00PM
Genetic and Epigenetic Regulation
Room: Anasazi Ballroom

Speaker 5 of 5
Kathryn N. Ivey, Tenaya Therapeutics, USA
Short Talk: Differential Regulation of Bicistronic Muscle miRNAs by the RNA Binding Protein, TDP-43

Tuesday, January 28 | 5:00PM - 5:00PM
On Own for Dinner


Wednesday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Wednesday, January 29 | 8:00AM - 11:00AM
Common Pathways in Cardiac and Skeletal Muscle Growth
Room: Anasazi Ballroom

Speaker 1 of 6
* Eva van Rooij, Hubrecht Institute, Netherlands

Wednesday, January 29 | 8:00AM - 11:00AM
Common Pathways in Cardiac and Skeletal Muscle Growth
Room: Anasazi Ballroom

Speaker 2 of 6
David A. Kass, Johns Hopkins Hospital, USA
Cardiac Mechano-Sensing Gone Bad: Elucidating the Mechanisms

Wednesday, January 29 | 8:00AM - 11:00AM
Common Pathways in Cardiac and Skeletal Muscle Growth
Room: Anasazi Ballroom

Speaker 3 of 6
David J. Glass, Regeneron Pharmaceuticals, Inc., USA
TGF-beta Signaling in Skeletal Muscle Hypertrophy

Wednesday, January 29 | 8:00AM - 11:00AM
Common Pathways in Cardiac and Skeletal Muscle Growth
Room: Anasazi Ballroom

Speaker 4 of 6
Denis C. Guttridge, Ohio State University, USA
Cancer Cachexia and the Muscle Microenvironment

Wednesday, January 29 | 8:00AM - 11:00AM
Common Pathways in Cardiac and Skeletal Muscle Growth
Room: Anasazi Ballroom

Speaker 5 of 6
Elizabeth M. McNally, Northwestern University, USA
Modifiers of Heart and Muscle Function


Wednesday, January 29 | 8:00AM - 11:00AM
Common Pathways in Cardiac and Skeletal Muscle Growth
Room: Anasazi Ballroom

Speaker 6 of 6
Matthew M. Goddeeris, University of Iowa, USA
Short Talk: LARGE Glycans on Dystroglycan Function as a Tunable Matrix Scaffold to Prevent Dystrophy

Wednesday, January 29 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Wednesday, January 29 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room/Eldorado Court


Wednesday, January 29 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Wednesday, January 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room/Eldorado Court


Wednesday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Wednesday, January 29 | 5:00PM - 7:00PM
Metabolic Regulation of Skeletal Muscle Mass and Function
Room: Anasazi Ballroom

Speaker 1 of 5
* Gustavo A. Nader, Karolinska Institute, Sweden

Wednesday, January 29 | 5:00PM - 7:00PM
Metabolic Regulation of Skeletal Muscle Mass and Function
Room: Anasazi Ballroom

Speaker 2 of 5
Ronald Cohn, Hospital for Sick Children, Canada
Serum/Glucocorticoid-Regulated Kinase 1 (SGK1) Mediates Muscle Homeostasis in Health and Disease

Wednesday, January 29 | 5:00PM - 7:00PM
Metabolic Regulation of Skeletal Muscle Mass and Function
Room: Anasazi Ballroom

Speaker 3 of 5
E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Insulin Signaling in the Regulation of Physiological versus Pathological Cardiac Hypertrophy

Wednesday, January 29 | 5:00PM - 7:00PM
Metabolic Regulation of Skeletal Muscle Mass and Function
Room: Anasazi Ballroom

Speaker 4 of 5
Daniel P. Kelly, University of Pennsylvania, USA
Delineating the Transcriptional Regulatory Circuitry Controlling Muscle Fiber Type

Wednesday, January 29 | 5:00PM - 7:00PM
Metabolic Regulation of Skeletal Muscle Mass and Function
Room: Anasazi Ballroom

Speaker 5 of 5
Brian Timothy O'Neill, University of Iowa, Carver College of Medicine, USA
Short Talk: Loss of Insulin and IGF-1 Receptor Signaling in Muscle Markedly Impairs Muscle Growth via Enhanced Autophagy

Wednesday, January 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Wednesday, January 29 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunset Room/Eldorado Court


Thursday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Thursday, January 30 | 8:00AM - 11:00AM
Metabolic Regulators of Cardiac Regeneration and Hypertrophy
Room: Anasazi Ballroom

Speaker 1 of 6
* Paul H. Goldspink, Medical College of Wisconsin, USA

Thursday, January 30 | 8:00AM - 11:00AM
Metabolic Regulators of Cardiac Regeneration and Hypertrophy
Room: Anasazi Ballroom

Speaker 2 of 6
Heinrich Taegtmeyer, University of Texas Medical School at Houston, USA
Metabolic Regulation of Myocardial Protein Turnover

Thursday, January 30 | 8:00AM - 11:00AM
Metabolic Regulators of Cardiac Regeneration and Hypertrophy
Room: Anasazi Ballroom

Speaker 3 of 6
James F. Martin, Baylor College of Medicine, USA
Hippo Signaling in Heart Regeneration

Thursday, January 30 | 8:00AM - 11:00AM
Metabolic Regulators of Cardiac Regeneration and Hypertrophy
Room: Anasazi Ballroom

Speaker 4 of 6
Karyn A. Esser, University of Florida, USA
Circadian Rhythms, Molecular Clock and Muscle Homeostasis

Thursday, January 30 | 8:00AM - 11:00AM
Metabolic Regulators of Cardiac Regeneration and Hypertrophy
Room: Anasazi Ballroom

Speaker 5 of 6
Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Diabetic Cardiomyopathy and Metabolic Remodeling in the Heart

Thursday, January 30 | 8:00AM - 11:00AM
Metabolic Regulators of Cardiac Regeneration and Hypertrophy
Room: Anasazi Ballroom

Speaker 6 of 6
Dawn A. Delfín, Ohio State University, USA
Short Talk: Dissecting the Role of Claudin-5 Reductions in Human and Mouse Cardiomyopathy

Thursday, January 30 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Thursday, January 30 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Thursday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Thursday, January 30 | 5:00PM - 7:00PM
Stem Cells and Cardioskeletal Growth
Room: Anasazi Ballroom

Speaker 1 of 5
* Elizabeth M. McNally, Northwestern University, USA

Thursday, January 30 | 5:00PM - 7:00PM
Stem Cells and Cardioskeletal Growth
Room: Anasazi Ballroom

Speaker 2 of 5
Gordon M. Keller, University Health Network, MaRS Centre, Canada
Generation of Cardiomyocytes and Epicardial-Like Cells from Human Pluripotent Stem Cells

Thursday, January 30 | 5:00PM - 7:00PM
Stem Cells and Cardioskeletal Growth
Room: Anasazi Ballroom

Speaker 3 of 5
Kenneth D. Poss, Duke University Medical Center, USA
Epicardial Cells and Heart Regeneration

Thursday, January 30 | 5:00PM - 7:00PM
Stem Cells and Cardioskeletal Growth
Room: Anasazi Ballroom

Speaker 4 of 5
Megan Beauchemin, University of New England, USA
Short Talk: miR-101 Controls Cardiomyocyte Proliferation and Scar Tissue Resolution during Zebrafish Heart Regeneration

Thursday, January 30 | 5:00PM - 7:00PM
Stem Cells and Cardioskeletal Growth
Room: Anasazi Ballroom

Speaker 5 of 5
Bernhard Kühn, Children's Hospital of Pittsburgh, USA
Short Talk: A Strategy for Regenerating Myocardium in Infants with Heart Disease

Thursday, January 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Thursday, January 30 | 8:00PM - 11:00PM
Entertainment
Room: Eldorado Court/Sunset Room


Thursday, January 30 | 8:00PM - 11:00PM
Cash Bar
Room: Eldorado Court/Sunset Room


Friday, January 31 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.