Web Desc
Omics Meets Cell Biology: Applications to Human Health and Disease
Organizer(s): Anne-Claude Gingras, Igor Stagljar and A.J. Marian Walhout
Date: February 18 - 23, 2014
Location: Sagebrush Inn & Suites, Taos, NM, USA
Sponsored by Biogen Idec and Novo Nordisk A/S. Supported by an educational donation provided by Amgen.
Summary of Meeting:
This conference brings together researchers who are applying and developing novel “Omics” approaches to interrogate system-level networks with an ultimate goal of understanding the functions of proteins of therapeutic importance. The conference will place a special emphasis on the interface between “Omics”-level sciences as applied to and integrated with classical molecular- and cell-biological studies. Because these large-scale projects involve multidisciplinary teams from both academic and biotech/pharma labs that are situated in different institutions all over the world, this meeting will provide a unique opportunity for diverse research groups to get together and discuss new ideas, approaches and novel results. More specifically, this conference explores how classical approaches to study biological processes, such as those used in cell biology, biochemistry and genetics, intersect with the new “Omics” technologies to advance our understanding of biological pathways associated with various human diseases. Extensive research in the past decade has shown that data sets generated by various “Omics” technologies represent a unique resource for biologists. However, a number of challenging technical and conceptual issues have been identified. These issues and resulting solutions will ultimately determine their impact on biology and medicine. Some of the issues include completeness and reproducibility of large-scale data sets, and how different data types obtained from the same and different systems can be integrated. Perhaps most importantly, a key objective of the meeting will be to explore the development of simple and robust methods for understanding the meaning of “Omics” data. This in turn will further facilitate the integration and dissemination of the data.
Scholarship Deadline: October 17 2013
Discounted Abstract Deadline: October 17 2013
Abstract Deadline: November 20 2013
Discounted Registration Deadline: December 16 2013
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Educational donation provided by AmgenBiogen IdecNovo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
Agilent TechnologiesCell Signaling Technology, Inc.Evotec
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Cellzome - a GSK Company

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
EMBO (European Molecular Biology Organization)
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 18 | 4:00PM - 8:00PM
Arrival and Registration
Room: Sagebrush Lobby & Cantina


Wednesday, February 19 | 7:00AM - 8:00AM
Breakfast
Room: Sagebrush Lobby & Cantina


Wednesday, February 19 | 8:00AM - 9:00AM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 2
* Igor Stagljar, University of Toronto, Canada

Wednesday, February 19 | 8:00AM - 9:00AM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 2 of 2
Brenda J. Andrews, University of Toronto, Canada
Exploring Biological Pathways and Networks Using Yeast Functional Genomics

Wednesday, February 19 | 9:00AM - 11:15AM
Proteomics Technologies: Applications to Disease
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Igor Stagljar, University of Toronto, Canada

Wednesday, February 19 | 9:00AM - 11:15AM
Proteomics Technologies: Applications to Disease
Room: Chamisa Ballroom 1

Speaker 2 of 6
Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada
Signaling Interactome Dynamics in Health and Disease

Wednesday, February 19 | 9:00AM - 11:15AM
Proteomics Technologies: Applications to Disease
Room: Chamisa Ballroom 1

Speaker 3 of 6
Ileana M. Cristea, Princeton University, USA
Proteomics Meets Virology

Wednesday, February 19 | 9:00AM - 11:15AM
Proteomics Technologies: Applications to Disease
Room: Chamisa Ballroom 1

Speaker 4 of 6
Mikko Taipale, Whitehead Institute, USA
Short Talk: A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways

Wednesday, February 19 | 9:00AM - 11:15AM
Proteomics Technologies: Applications to Disease
Room: Chamisa Ballroom 1

Speaker 5 of 6
Martin Beck, European Molecular Biology Laboratory, Germany
Short Talk: Cell-Type Specific Nuclear Pores: How the Nuclear Transport System Is Fine-Tuned toward Context-Specific Needs

Wednesday, February 19 | 9:00AM - 11:15AM
Proteomics Technologies: Applications to Disease
Room: Chamisa Ballroom 1

Speaker 6 of 6
Bernd Wollscheid, ETH Zürich, Switzerland
Decoding Ligand Receptor Interactions

Wednesday, February 19 | 9:40AM - 10:00AM
Coffee Break
Room: Chamisa Lobby


Wednesday, February 19 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Wednesday, February 19 | 11:15AM - 12:15PM
Panel: Industry Options in 'Omics': From Technology Developm
ent to Applications
Room: Chamisa Ballroom 1
The goal of this workshop is to present young researchers with the evidence for why Industry is a good option for doing OMICs-based sciences after they complete their PhD and/or postdoctoral training.
Speaker 1 of 4
* Igor Stagljar, University of Toronto, Canada

Wednesday, February 19 | 11:15AM - 12:15PM
Panel: Industry Options in 'Omics': From Technology Developm
ent to Applications
Room: Chamisa Ballroom 1
The goal of this workshop is to present young researchers with the evidence for why Industry is a good option for doing OMICs-based sciences after they complete their PhD and/or postdoctoral training.
Speaker 2 of 4
Giulio Superti-Furga, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria

Wednesday, February 19 | 11:15AM - 12:15PM
Panel: Industry Options in 'Omics': From Technology Developm
ent to Applications
Room: Chamisa Ballroom 1
The goal of this workshop is to present young researchers with the evidence for why Industry is a good option for doing OMICs-based sciences after they complete their PhD and/or postdoctoral training.
Speaker 3 of 4
Domagoj Vucic, Genentech, Inc., USA

Wednesday, February 19 | 11:15AM - 12:15PM
Panel: Industry Options in 'Omics': From Technology Developm
ent to Applications
Room: Chamisa Ballroom 1
The goal of this workshop is to present young researchers with the evidence for why Industry is a good option for doing OMICs-based sciences after they complete their PhD and/or postdoctoral training.
Speaker 4 of 4
Sabine Bahn, University of Cambridge, UK

Wednesday, February 19 | 12:15PM - 5:00PM
On Own for Lunch and Recreation


Wednesday, February 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, February 19 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, February 19 | 5:00PM - 7:00PM
Omics Meets Genetics and Gene Expression
Room: Chamisa Ballroom 1

Speaker 1 of 5
* A.J. Marian Walhout, University of Massachusetts Medical School, USA

Wednesday, February 19 | 5:00PM - 7:00PM
Omics Meets Genetics and Gene Expression
Room: Chamisa Ballroom 1

Speaker 2 of 5
Heng Zhu, Johns Hopkins University School of Medicine, USA
DNA Methylation Presents Distinct Binding Sites for Human Transcription Factors

Wednesday, February 19 | 5:00PM - 7:00PM
Omics Meets Genetics and Gene Expression
Room: Chamisa Ballroom 1

Speaker 3 of 5
Michael P. Snyder, Stanford University School of Medicine, USA
Personalized Medicine: Personal Omics Profiling of Healthy and Disease States

Wednesday, February 19 | 5:00PM - 7:00PM
Omics Meets Genetics and Gene Expression
Room: Chamisa Ballroom 1

Speaker 4 of 5
Marko Jovanovic, Max Planck Institute of Brain Research, Germany
Short Talk: Quantitating the Mammalian Transcriptome and Proteome Relationship in a Dynamic Response to Pathogen Signal

Wednesday, February 19 | 5:00PM - 7:00PM
Omics Meets Genetics and Gene Expression
Room: Chamisa Ballroom 1

Speaker 5 of 5
Michael J. Lee, University of Massachusetts Medical School, USA
Dynamic Rewiring of Apoptotic Signaling: A Network-Centric Study of Combination Therapies for Triple-Negative Breast Cancer

Wednesday, February 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Wednesday, February 19 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Thursday, February 20 | 7:00AM - 8:00AM
Breakfast
Room: Sagebrush Lobby & Cantina


Thursday, February 20 | 8:00AM - 11:00AM
From Genotype and Phenotype
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Markus Ralser, Francis Crick Institute, UK

Thursday, February 20 | 8:00AM - 11:00AM
From Genotype and Phenotype
Room: Chamisa Ballroom 1

Speaker 2 of 6
Charlie M. Boone, University of Toronto, Canada
The Genetic Landscape of a Cell

Thursday, February 20 | 8:00AM - 11:00AM
From Genotype and Phenotype
Room: Chamisa Ballroom 1

Speaker 3 of 6
Andrew Fraser, University of Toronto, Canada
A Whole Can of Worms: The Effect of Genome Evolution on Loss-of-Function Phenotypes in Different Nematodes

Thursday, February 20 | 8:00AM - 11:00AM
From Genotype and Phenotype
Room: Chamisa Ballroom 1

Speaker 4 of 6
Yoshikazu Ohya, University of Tokyo, Japan
High-Resolution Phenotyping to Elucidate Essential Complex Cellular Processes

Thursday, February 20 | 8:00AM - 11:00AM
From Genotype and Phenotype
Room: Chamisa Ballroom 1

Speaker 5 of 6
Louise Evans, Institute of Cancer Research, UK
Short Talk: High-Content Combinatorial RNAi Screens Reveal Large-Scale Signaling Networks Regulating Cytokinesis

Thursday, February 20 | 8:00AM - 11:00AM
From Genotype and Phenotype
Room: Chamisa Ballroom 1

Speaker 6 of 6
Giulio Superti-Furga, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Molecular Networks: Drug Action and Genome-Informed Medicine

Thursday, February 20 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, February 20 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Thursday, February 20 | 11:00AM - 12:00PM
Panel: Academic Careers in 'Omics': Starting Up a Successful
Research Program
Room: Chamisa Ballroom 1

Speaker 1 of 1
* Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada

Thursday, February 20 | 12:00PM - 5:00PM
On Own for Lunch and Recreation


Thursday, February 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Thursday, February 20 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Thursday, February 20 | 5:00PM - 7:00PM
Omics Meets Drug Discovery
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Giulio Superti-Furga, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria

Thursday, February 20 | 5:00PM - 7:00PM
Omics Meets Drug Discovery
Room: Chamisa Ballroom 1

Speaker 2 of 5
Stefan Knapp, University of Oxford, UK
Using Structural (Chemo)-Proteomics as a Tool for Target Discovery

Thursday, February 20 | 5:00PM - 7:00PM
Omics Meets Drug Discovery
Room: Chamisa Ballroom 1

Speaker 3 of 5
Domagoj Vucic, Genentech, Inc., USA
Targeting Ubiquitin Ligases in Cancer and Inflammation

Thursday, February 20 | 5:00PM - 7:00PM
Omics Meets Drug Discovery
Room: Chamisa Ballroom 1

Speaker 4 of 5
Gerard Drewes, GlaxoSmithKline, Germany
Charting Drug Target Complexes with Small Molecules

Thursday, February 20 | 5:00PM - 7:00PM
Omics Meets Drug Discovery
Room: Chamisa Ballroom 1

Speaker 5 of 5
Irma Lemmens, Ghent University/VIB, Belgium
Short Talk: MAPPIT and KISS, Two Complementary Methods to Detect Protein-Protein and Protein-Small Molecule Interactions in Living Mammalian Cells

Thursday, February 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Thursday, February 20 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Friday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Sagebrush Lobby & Cantina


Friday, February 21 | 8:00AM - 11:15AM
Computational Analysis of Systems Biology
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Anne-Claude Gavin, European Molecular Biology Laboratory, Germany

Friday, February 21 | 8:00AM - 11:15AM
Computational Analysis of Systems Biology
Room: Chamisa Ballroom 1

Speaker 2 of 7
Trey Ideker, University of California, San Diego, USA
Mapping the Genetic Networks of Cancer

Friday, February 21 | 8:00AM - 11:15AM
Computational Analysis of Systems Biology
Room: Chamisa Ballroom 1

Speaker 3 of 7
Nuno Bandeira, University of California, San Diego, USA
The Transformative Role of Data Repositories in High Throughput Proteomics

Friday, February 21 | 8:00AM - 11:15AM
Computational Analysis of Systems Biology
Room: Chamisa Ballroom 1

Speaker 4 of 7
Olga G. Troyanskaya, Princeton University, USA
From Functional Genomics Studies to the Cell-Lineage Specific View of Human Disease

Friday, February 21 | 8:00AM - 11:15AM
Computational Analysis of Systems Biology
Room: Chamisa Ballroom 1

Speaker 5 of 7
Jonathan H. Young, Texas Tech University Health Sciences Center, USA
Short Talk: Novel Drug Targets for Non-Small Cell Lung Cancer from Computational Analysis of a Whole Genome RNAi Screen

Friday, February 21 | 8:00AM - 11:15AM
Computational Analysis of Systems Biology
Room: Chamisa Ballroom 1

Speaker 6 of 7
Murat Tasan, University of Toronto, Canada
Short Talk: Causal Networks in Genome-Wide Association Studies

Friday, February 21 | 8:00AM - 11:15AM
Computational Analysis of Systems Biology
Room: Chamisa Ballroom 1

Speaker 7 of 7
A.J. Marian Walhout, University of Massachusetts Medical School, USA
Nutritional Regulatory Networks

Friday, February 21 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Friday, February 21 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Friday, February 21 | 11:15AM - 12:15PM
Panel: Publishing High Impact 'Omics' Papers
Room: Chamisa Ballroom 1

Speaker 1 of 1
* A.J. Marian Walhout, University of Massachusetts Medical School, USA

Friday, February 21 | 12:15PM - 5:00PM
On Own for Lunch and Recreation


Friday, February 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Friday, February 21 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Friday, February 21 | 5:00PM - 7:00PM
An Integrated View of Cellular Signaling
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Ileana M. Cristea, Princeton University, USA

Friday, February 21 | 5:00PM - 7:00PM
An Integrated View of Cellular Signaling
Room: Chamisa Ballroom 1

Speaker 2 of 5
Shohei Koide, New York University Langone Health, USA
Controlling Signaling Networks by Protein Design

Friday, February 21 | 5:00PM - 7:00PM
An Integrated View of Cellular Signaling
Room: Chamisa Ballroom 1

Speaker 3 of 5
Walter Kolch, University College Dublin, Ireland
Signalling Networks Regulated by Compartmentalised Ras Signalling

Friday, February 21 | 5:00PM - 7:00PM
An Integrated View of Cellular Signaling
Room: Chamisa Ballroom 1

Speaker 4 of 5
Anne E. White, Harvard Medical School, USA
Short Talk: Quantitative Analysis of the Hippo Pathway in Low and High-Density Cells

Friday, February 21 | 5:00PM - 7:00PM
An Integrated View of Cellular Signaling
Room: Chamisa Ballroom 1

Speaker 5 of 5
Igor Stagljar, University of Toronto, Canada
Dynamic Interactomes of “Druggable” Membrane Proteins: Roles in Human Health and Disease

Friday, February 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Friday, February 21 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa Ballroom 2


Saturday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Sagebrush Lobby & Cantina


Saturday, February 22 | 8:00AM - 11:00AM
Global Analysis of Metabolic and Lipidomics Networks
Room: Chamisa Ballroom 1

Speaker 1 of 4
Markus Ralser, Francis Crick Institute, UK
EMBO Young Investigator Lecture: Genetic Basis of Stability and Flexibility of Metabolic Networks

Saturday, February 22 | 8:00AM - 11:00AM
Global Analysis of Metabolic and Lipidomics Networks
Room: Chamisa Ballroom 1

Speaker 2 of 4
Markus R. Wenk, National University of Singapore, Singapore
Natural Variation of Lipidomes

Saturday, February 22 | 8:00AM - 11:00AM
Global Analysis of Metabolic and Lipidomics Networks
Room: Chamisa Ballroom 1

Speaker 3 of 4
Anne-Claude Gavin, European Molecular Biology Laboratory, Germany
Expending the Interaction Space: Protein-Lipid Networks

Saturday, February 22 | 8:00AM - 11:00AM
Global Analysis of Metabolic and Lipidomics Networks
Room: Chamisa Ballroom 1

Speaker 4 of 4
Peer Bork, European Molecular Biology Laboratory, Germany
Metagenomic Analysis of the Human Gut Microbiome: Variation, Stratification and Associations to Disease


Saturday, February 22 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Saturday, February 22 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Saturday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Saturday, February 22 | 5:00PM - 6:45PM
Omics and Neurodegenerative Disorders
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Bernd Wollscheid, ETH Zürich, Switzerland

Saturday, February 22 | 5:00PM - 6:45PM
Omics and Neurodegenerative Disorders
Room: Chamisa Ballroom 1

Speaker 2 of 4
Sabine Bahn, University of Cambridge, UK
Serum Biomarkers for Psychiatric Disorders

Saturday, February 22 | 5:00PM - 6:45PM
Omics and Neurodegenerative Disorders
Room: Chamisa Ballroom 1

Speaker 3 of 4
Erich E. Wanker, Max Delbrueck Center for Molecular Medicine, Germany
From Protein Interaction Networks to Neurodegenerative Disease Mechanisms

Saturday, February 22 | 5:00PM - 6:45PM
Omics and Neurodegenerative Disorders
Room: Chamisa Ballroom 1

Speaker 4 of 4
Eric J. Bennett, University of California, San Diego, USA
Using the Ubiquitin-Modified Proteome to Evaluate Protein Homeostasis Function

Saturday, February 22 | 6:45PM - 7:30PM
Closing Address
Room: Chamisa Ballroom 1

Speaker 1 of 2
* Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada

Saturday, February 22 | 6:45PM - 7:30PM
Closing Address
Room: Chamisa Ballroom 1

Speaker 2 of 2
Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Network Driven Protein Biomarker Discovery and Validation

Saturday, February 22 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Saturday, February 22 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Saturday, February 22 | 8:30PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Sunday, February 23 | 10:25AM - 10:25AM
Departure


*Session Chair.