Web Desc
The NF-kappaB System in Health and Disease
Organizer(s): Alexander Hoffmann and Louis M. Staudt
Date: February 23 - 28, 2014
Location: Keystone Resort, Keystone, CO, USA
Sponsored by AstraZeneca
For important information on the coronavirus, please click here
Summary of Meeting:
The NF-kappaB System plays key roles in diverse physiological and pathological processes, involving innate and adaptive immunity, and many organs and cell types. The family of NF-kappaB transcription factors have overlapping and specific functions, and are regulated through numerous interconnected molecular mechanisms. The NF-kappaB System refers to the gene regulatory and signal regulatory networks (GRNs and SRNs), within which NF-kappaB transcription factors exert their activities. Those regulatory networks include mitogen-activated kinases, caspases and other apoptotic and necroptotic regulators, regulators of autophagy, cytoskeletal organization, and proliferation, as well as the interferon-regulatory innate immune network. Indeed understanding these processes as an interconnected system is paramount to studies of disease, as manifested by complex immunological, inflammatory, and tumor pathologies. To address these complexities and move towards a predictive understanding, this conference will emphasize the consideration of regulatory interactions, quantitative measurements, in silico modeling, and genome scale studies. It will provide an overview of the field and catalyze scientific interactions in the age of Systems Biology to advance post-genomic Immunology.
Scholarship Deadline: October 23 2013
Discounted Abstract Deadline: October 23 2013
Abstract Deadline: November 22 2013
Discounted Registration Deadline: December 19 2013
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZeneca
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI108137-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, February 23 | 4:00PM - 8:00PM
Arrival and Registration
Room: Keystone Lodge Lobby


Monday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: Longs/Quandary Peaks


Monday, February 24 | 8:00AM - 9:10AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 1 of 3
* Alexander Hoffmann, University of California, Los Angeles, USA

Monday, February 24 | 8:00AM - 9:10AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 2 of 3
* Louis M. Staudt, NCI, National Institutes of Health, USA

Monday, February 24 | 8:00AM - 9:10AM
Welcome and Keynote Address
Room: Grays Peak

Speaker 3 of 3
David Baltimore, California Institute of Technology, USA
NF-kappaB: Still Surprising

Monday, February 24 | 9:10AM - 11:15AM
NF-kappaB within Gene Regulatory Networks
Room: Grays Peak
The function of NF-kappaB transcription factors within the gene regulatory networks, and the mechanisms that mediate stimulus-specific and cell-type specific gene expression programs.
Speaker 1 of 6
* Alexander Hoffmann, University of California, Los Angeles, USA

Monday, February 24 | 9:10AM - 11:15AM
NF-kappaB within Gene Regulatory Networks
Room: Grays Peak
The function of NF-kappaB transcription factors within the gene regulatory networks, and the mechanisms that mediate stimulus-specific and cell-type specific gene expression programs.
Speaker 2 of 6
Andrea Califano, Columbia University, USA
NF-kappaB Is a Master Regulator of Mutant-SOD1 Toxicity in an in vitro Model of ALS

Monday, February 24 | 9:10AM - 11:15AM
NF-kappaB within Gene Regulatory Networks
Room: Grays Peak
The function of NF-kappaB transcription factors within the gene regulatory networks, and the mechanisms that mediate stimulus-specific and cell-type specific gene expression programs.
Speaker 3 of 6
Aviv Regev, Massachusetts Institute of Technology, USA
Systems Biology of Inflammatory Gene Expression

Monday, February 24 | 9:10AM - 11:15AM
NF-kappaB within Gene Regulatory Networks
Room: Grays Peak
The function of NF-kappaB transcription factors within the gene regulatory networks, and the mechanisms that mediate stimulus-specific and cell-type specific gene expression programs.
Speaker 4 of 6
Irina A. Udalova, University of Oxford, UK
The Specificity of the NF-kappaB Dimer Family

Monday, February 24 | 9:10AM - 11:15AM
NF-kappaB within Gene Regulatory Networks
Room: Grays Peak
The function of NF-kappaB transcription factors within the gene regulatory networks, and the mechanisms that mediate stimulus-specific and cell-type specific gene expression programs.
Speaker 5 of 6
Benjamin E. Gewurz, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: The Genomic Landscape of NF-kappaB Binding

Monday, February 24 | 9:10AM - 11:15AM
NF-kappaB within Gene Regulatory Networks
Room: Grays Peak
The function of NF-kappaB transcription factors within the gene regulatory networks, and the mechanisms that mediate stimulus-specific and cell-type specific gene expression programs.
Speaker 6 of 6
David Spiller, University of Manchester, UK
Short Talk: Measuring the Interactions of NF-kappaB Proteins Inside Living Cells

Monday, February 24 | 9:40AM - 10:00AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 24 | 11:15AM - 1:00PM
Poster Setup
Room: Longs/Quandary Peaks


Monday, February 24 | 11:15AM - 2:30PM
On Own for Lunch and Recreation


Monday, February 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs/Quandary Peaks


Monday, February 24 | 2:30PM - 4:30PM
Workshop 1 for Highly Innovative, Recent Studies to be Prese
nted
Room: Grays Peak

Speaker 1 of 8
* Alexander Hoffmann, University of California, Los Angeles, USA

Monday, February 24 | 2:30PM - 4:30PM
Workshop 1 for Highly Innovative, Recent Studies to be Prese
nted
Room: Grays Peak

Speaker 2 of 8
Trevor William Siggers, Boston University, USA
Gene Targeting by Irf3 and p65

Monday, February 24 | 2:30PM - 4:30PM
Workshop 1 for Highly Innovative, Recent Studies to be Prese
nted
Room: Grays Peak

Speaker 3 of 8
Soumen Basak, National Institute of Immunology, India
Developmental Lymphotoxin-beta Receptor Reinforces TLR4 Triggered Inflammatory NF-kappaB Response through Signaling Crosstalk to Potentiate Pathogen Clearance

Monday, February 24 | 2:30PM - 4:30PM
Workshop 1 for Highly Innovative, Recent Studies to be Prese
nted
Room: Grays Peak

Speaker 4 of 8
Véronique I. Baud, Institut Cochin, France
IKK Phosphorylates RelB to Modulate its Promoter Specificity and Promote Fibroblast Migration Downstream of TNF Receptors

Monday, February 24 | 2:30PM - 4:30PM
Workshop 1 for Highly Innovative, Recent Studies to be Prese
nted
Room: Grays Peak

Speaker 5 of 8
Tom Huxford, San Diego State University, USA
Activation and Specificity of an Engineered Monomeric IKK2

Monday, February 24 | 2:30PM - 4:30PM
Workshop 1 for Highly Innovative, Recent Studies to be Prese
nted
Room: Grays Peak

Speaker 6 of 8
Veronique Schaeffer, Goethe University, Germany
OTULIN Binds to the PUB domain of HOIP and Controls the NF-kappaB Signaling

Monday, February 24 | 2:30PM - 4:30PM
Workshop 1 for Highly Innovative, Recent Studies to be Prese
nted
Room: Grays Peak

Speaker 7 of 8
Domagoj Vucic, Genentech, Inc., USA
Diverse Ubiquitin Modifications Regulate NF-kappaB Activation

Monday, February 24 | 2:30PM - 4:30PM
Workshop 1 for Highly Innovative, Recent Studies to be Prese
nted
Room: Grays Peak

Speaker 8 of 8
Malini Sen, Indian Institute of Chemical Biology, India
Wnt5a-NFkappaB (p65) Homeostatic Circuitry Is Important for Innate Immunity

Monday, February 24 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 24 | 5:00PM - 7:00PM
NF-kappaB Signaling System
Room: Grays Peak
The NF-kappaB signaling system consists of more than a dozen dimers controlled by several IkappaB activities. Understanding how cell-type-specific and stimulus-specific control is achieved remains a challenge.
Speaker 1 of 5
* Sankar Ghosh, Columbia University, USA

Monday, February 24 | 5:00PM - 7:00PM
NF-kappaB Signaling System
Room: Grays Peak
The NF-kappaB signaling system consists of more than a dozen dimers controlled by several IkappaB activities. Understanding how cell-type-specific and stimulus-specific control is achieved remains a challenge.
Speaker 2 of 5
Elizabeth A. Komives, University of California, San Diego, USA
IkappaB Control of NF-kappaB Activation and Inactivation

Monday, February 24 | 5:00PM - 7:00PM
NF-kappaB Signaling System
Room: Grays Peak
The NF-kappaB signaling system consists of more than a dozen dimers controlled by several IkappaB activities. Understanding how cell-type-specific and stimulus-specific control is achieved remains a challenge.
Speaker 3 of 5
Jana Wolf, Max Delbrück Center for Molecular Medicine, Germany
Mathematical Modeling of Regulatory Modules in NF-kappaB Signaling

Monday, February 24 | 5:00PM - 7:00PM
NF-kappaB Signaling System
Room: Grays Peak
The NF-kappaB signaling system consists of more than a dozen dimers controlled by several IkappaB activities. Understanding how cell-type-specific and stimulus-specific control is achieved remains a challenge.
Speaker 4 of 5
Gourisankar Ghosh, University of California, San Diego, USA
Understanding NF-kappaB Regulation from in vitro Experiments

Monday, February 24 | 5:00PM - 7:00PM
NF-kappaB Signaling System
Room: Grays Peak
The NF-kappaB signaling system consists of more than a dozen dimers controlled by several IkappaB activities. Understanding how cell-type-specific and stimulus-specific control is achieved remains a challenge.
Speaker 5 of 5
Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Precursor Cross-Talk and Nuclear Signatures of Non-Canonical NF-kappaB Activation

Monday, February 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks


Monday, February 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Longs/Quandary Peaks


Tuesday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Longs/Quandary Peaks


Tuesday, February 25 | 8:00AM - 11:00AM
The Inflammatory Signaling Network
Room: Grays Peak
NF-kappaB is one of several signaling systems within a larger network that controls inflammation. Understanding how signaling systems are coordinated remains an important challenge.
Speaker 1 of 7
* Genhong Cheng, University of California, Los Angeles, USA

Tuesday, February 25 | 8:00AM - 11:00AM
The Inflammatory Signaling Network
Room: Grays Peak
NF-kappaB is one of several signaling systems within a larger network that controls inflammation. Understanding how signaling systems are coordinated remains an important challenge.
Speaker 2 of 7
Vishva M. Dixit, Genentech, Inc., USA
RIPK3: Role of the Kinase Activity in Necroptosis

Tuesday, February 25 | 8:00AM - 11:00AM
The Inflammatory Signaling Network
Room: Grays Peak
NF-kappaB is one of several signaling systems within a larger network that controls inflammation. Understanding how signaling systems are coordinated remains an important challenge.
Speaker 3 of 7
Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA
Short Talk: Noncanonical NF-kappaB Signaling in Host Defense and Inflammation

Tuesday, February 25 | 8:00AM - 11:00AM
The Inflammatory Signaling Network
Room: Grays Peak
NF-kappaB is one of several signaling systems within a larger network that controls inflammation. Understanding how signaling systems are coordinated remains an important challenge.
Speaker 4 of 7
Tomasz Kordula, Virginia Commonwealth University, USA
K63-linked Polyubiquitination of IRF1 is Essential for IL-1-Induced Production of Chemokines CCL5 and CXCL10

Tuesday, February 25 | 8:00AM - 11:00AM
The Inflammatory Signaling Network
Room: Grays Peak
NF-kappaB is one of several signaling systems within a larger network that controls inflammation. Understanding how signaling systems are coordinated remains an important challenge.
Speaker 5 of 7
Averil I. Ma, University of California, San Francisco, USA
Attenuating Inflammation with Deubiquitinases

Tuesday, February 25 | 8:00AM - 11:00AM
The Inflammatory Signaling Network
Room: Grays Peak
NF-kappaB is one of several signaling systems within a larger network that controls inflammation. Understanding how signaling systems are coordinated remains an important challenge.
Speaker 6 of 7
Roberto Nitsch, IMBA - Institute for Molecular Biotechnology, Austria
Short Talk: The Tumor Suppressor HACE1 Is a Critical Regulator of TNFR1 Mediated Cell Fate

Tuesday, February 25 | 8:00AM - 11:00AM
The Inflammatory Signaling Network
Room: Grays Peak
NF-kappaB is one of several signaling systems within a larger network that controls inflammation. Understanding how signaling systems are coordinated remains an important challenge.
Speaker 7 of 7
Fumiyo Ikeda, IMBA – Institute of Molecular Biotechnology, Austria
Short Talk: Sharpin Prevents TNFR1-Induced Keratinocyte Apoptosis and Skin Inflammation by Linear Ubiquitination of FADD

Tuesday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 25 | 11:00AM - 1:00PM
Poster Setup
Room: Longs/Quandary Peaks


Tuesday, February 25 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, February 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs/Quandary Peaks


Tuesday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 25 | 5:00PM - 7:00PM
Innate Immune Signaling Networks
Room: Grays Peak
NF-kappaB plays a critical role in innate immune responses when coordinated with other signaling systems. Understanding the molecular mechanisms and systems properties of the innate immune signaling networks remains an important challenge.
Speaker 1 of 5
* Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA

Tuesday, February 25 | 5:00PM - 7:00PM
Innate Immune Signaling Networks
Room: Grays Peak
NF-kappaB plays a critical role in innate immune responses when coordinated with other signaling systems. Understanding the molecular mechanisms and systems properties of the innate immune signaling networks remains an important challenge.
Speaker 2 of 5
Takashi Fujita, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan
Regulation of Antiviral Innate Immunity by RIG-I-Like Receptors

Tuesday, February 25 | 5:00PM - 7:00PM
Innate Immune Signaling Networks
Room: Grays Peak
NF-kappaB plays a critical role in innate immune responses when coordinated with other signaling systems. Understanding the molecular mechanisms and systems properties of the innate immune signaling networks remains an important challenge.
Speaker 3 of 5
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
The cGAS-cGAMP-STING Pathway Detects Cytosolic DNA and Induces Type-I Interferons

Tuesday, February 25 | 5:00PM - 7:00PM
Innate Immune Signaling Networks
Room: Grays Peak
NF-kappaB plays a critical role in innate immune responses when coordinated with other signaling systems. Understanding the molecular mechanisms and systems properties of the innate immune signaling networks remains an important challenge.
Speaker 4 of 5
Gregory M. Barton, University of California, Berkeley, USA
Toll-Like Receptors in Health and Disease

Tuesday, February 25 | 5:00PM - 7:00PM
Innate Immune Signaling Networks
Room: Grays Peak
NF-kappaB plays a critical role in innate immune responses when coordinated with other signaling systems. Understanding the molecular mechanisms and systems properties of the innate immune signaling networks remains an important challenge.
Speaker 5 of 5
Rachel A. Gottschalk, NIAID, National Institutes of Health, USA
Short Talk: Integration of NF-kappaB and MAPK Activation Dynamics Determines TLR Ligand Sensitivity

Tuesday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks


Tuesday, February 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Longs/Quandary Peaks


Wednesday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Longs/Quandary Peaks


Wednesday, February 26 | 8:00AM - 11:15AM
Lymphoid Signaling Systems
Room: Grays Peak
Within lymphoid cells, NF-kappaB plays critical roles in controlling survival and proliferation. Misregulated NF-kappaB is at the root of immunological diseases and malignancies.
Speaker 1 of 7
* Louis M. Staudt, NCI, National Institutes of Health, USA

Wednesday, February 26 | 8:00AM - 11:15AM
Lymphoid Signaling Systems
Room: Grays Peak
Within lymphoid cells, NF-kappaB plays critical roles in controlling survival and proliferation. Misregulated NF-kappaB is at the root of immunological diseases and malignancies.
Speaker 2 of 7
Sankar Ghosh, Columbia University, USA
Understanding the Mechanism by which IkappaB Beta Is Regulated during the Inflammatory Response

Wednesday, February 26 | 8:00AM - 11:15AM
Lymphoid Signaling Systems
Room: Grays Peak
Within lymphoid cells, NF-kappaB plays critical roles in controlling survival and proliferation. Misregulated NF-kappaB is at the root of immunological diseases and malignancies.
Speaker 3 of 7
Margot Thome, University of Lausanne, Switzerland
MALT1-Dependent Lymphoid Signaling and B-Cell Malignancy

Wednesday, February 26 | 8:00AM - 11:15AM
Lymphoid Signaling Systems
Room: Grays Peak
Within lymphoid cells, NF-kappaB plays critical roles in controlling survival and proliferation. Misregulated NF-kappaB is at the root of immunological diseases and malignancies.
Speaker 4 of 7
Alexander Hoffmann, University of California, Los Angeles, USA
The NF-kappaB Signaling System within the Waddington Landscapes of Immune Cells

Wednesday, February 26 | 8:00AM - 11:15AM
Lymphoid Signaling Systems
Room: Grays Peak
Within lymphoid cells, NF-kappaB plays critical roles in controlling survival and proliferation. Misregulated NF-kappaB is at the root of immunological diseases and malignancies.
Speaker 5 of 7
Robert C. Rickert, Pfizer Inc., USA
Functional Specificity of NF-kappaB Pathways in B-Cell Fate Decisions

Wednesday, February 26 | 8:00AM - 11:15AM
Lymphoid Signaling Systems
Room: Grays Peak
Within lymphoid cells, NF-kappaB plays critical roles in controlling survival and proliferation. Misregulated NF-kappaB is at the root of immunological diseases and malignancies.
Speaker 6 of 7
Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA
Short Talk: The NF-kappaB Regulator Bcl-3 Profoundly Impacts Immune Responses in Health and Disease via Distinct, Cell-Specific Functions

Wednesday, February 26 | 8:00AM - 11:15AM
Lymphoid Signaling Systems
Room: Grays Peak
Within lymphoid cells, NF-kappaB plays critical roles in controlling survival and proliferation. Misregulated NF-kappaB is at the root of immunological diseases and malignancies.
Speaker 7 of 7
Takuya Uehata, Kyoto University, Japan
Short Talk: Malt-1 Mediated Cleavage of Regnase-1 Regulates CD4 T Activation

Wednesday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 26 | 11:15AM - 1:00PM
Poster Setup
Room: Longs/Quandary Peaks


Wednesday, February 26 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Wednesday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Longs/Quandary Peaks


Wednesday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 26 | 5:00PM - 7:00PM
Cell Decision Systems
Room: Grays Peak
The NF-kappaB signaling system responds to a variety of noxious stimuli. How it participates in determining cellular responses and cellular decision making is studied effectively using the iterative Systems Biology approach.
Speaker 1 of 5
* Aviv Regev, Massachusetts Institute of Technology, USA

Wednesday, February 26 | 5:00PM - 7:00PM
Cell Decision Systems
Room: Grays Peak
The NF-kappaB signaling system responds to a variety of noxious stimuli. How it participates in determining cellular responses and cellular decision making is studied effectively using the iterative Systems Biology approach.
Speaker 2 of 5
Toby Lawrence, INSERM, France
NF-kB and Dendritic Cell Maturation

Wednesday, February 26 | 5:00PM - 7:00PM
Cell Decision Systems
Room: Grays Peak
The NF-kappaB signaling system responds to a variety of noxious stimuli. How it participates in determining cellular responses and cellular decision making is studied effectively using the iterative Systems Biology approach.
Speaker 3 of 5
Suzanne Gaudet, Dana-Farber Cancer Institute/Harvard Medical School, USA
Measuring, Modeling and Leveraging Cell-to-Cell Variability in Responses to TNF

Wednesday, February 26 | 5:00PM - 7:00PM
Cell Decision Systems
Room: Grays Peak
The NF-kappaB signaling system responds to a variety of noxious stimuli. How it participates in determining cellular responses and cellular decision making is studied effectively using the iterative Systems Biology approach.
Speaker 4 of 5
Shigeki Miyamoto, University of Wisconsin, Madison, USA
Genotoxic NF-kappaB Responses: Regulation of Nuclear NEMO Functions

Wednesday, February 26 | 5:00PM - 7:00PM
Cell Decision Systems
Room: Grays Peak
The NF-kappaB signaling system responds to a variety of noxious stimuli. How it participates in determining cellular responses and cellular decision making is studied effectively using the iterative Systems Biology approach.
Speaker 5 of 5
Myong-Hee Mia Sung, NIA, National Institutes of Health, USA
Short Talk: Switching of Feedback Dominance in LPS Dose Discrimination by Macrophages

Wednesday, February 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks


Wednesday, February 26 | 7:30PM - 10:00PM
Poster Session 3
Room: Longs/Quandary Peaks


Thursday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Longs/Quandary Peaks


Thursday, February 27 | 8:00AM - 11:00AM
Signaling Systems in Cancer
Room: Grays Peak
NF-kappaB has been implicated in the pathogenesis of many cancers. Its precise role seems to be cancer specific and depends on the contextual network.
Speaker 1 of 7
* Margot Thome, University of Lausanne, Switzerland

Thursday, February 27 | 8:00AM - 11:00AM
Signaling Systems in Cancer
Room: Grays Peak
NF-kappaB has been implicated in the pathogenesis of many cancers. Its precise role seems to be cancer specific and depends on the contextual network.
Speaker 2 of 7
Michael Karin, University of California, San Diego, USA
NF-kappaB Revisited in Liver Cancer; from a Tumor Suppressor to a Key Factor in Viral Hepatitis and Non-Alcoholic Steato-Hepatitis (NASH) Related HCC

Thursday, February 27 | 8:00AM - 11:00AM
Signaling Systems in Cancer
Room: Grays Peak
NF-kappaB has been implicated in the pathogenesis of many cancers. Its precise role seems to be cancer specific and depends on the contextual network.
Speaker 3 of 7
Louis M. Staudt, NCI, National Institutes of Health, USA
Oncogenic Signaling in Lymphoma

Thursday, February 27 | 8:00AM - 11:00AM
Signaling Systems in Cancer
Room: Grays Peak
NF-kappaB has been implicated in the pathogenesis of many cancers. Its precise role seems to be cancer specific and depends on the contextual network.
Speaker 4 of 7
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Inflammasomes in Health, Dysbiosis and Disease

Thursday, February 27 | 8:00AM - 11:00AM
Signaling Systems in Cancer
Room: Grays Peak
NF-kappaB has been implicated in the pathogenesis of many cancers. Its precise role seems to be cancer specific and depends on the contextual network.
Speaker 5 of 7
Nicole Heise, Columbia University, USA
Short Talk: Conditional Ablation of the Canonical NF-kappaB Subunits RELA or c-REL in Germinal Center B Cells Abolishes the Generation of High-Affinity B Cells at Distinct Stages

Thursday, February 27 | 8:00AM - 11:00AM
Signaling Systems in Cancer
Room: Grays Peak
NF-kappaB has been implicated in the pathogenesis of many cancers. Its precise role seems to be cancer specific and depends on the contextual network.
Speaker 6 of 7
James Q. Wang, National Cancer Institute, N.I.H., USA
Short Talk: Cooperative Effects of MYD88, BCL-2, CD79B and TNFAIP3 Mutations on B Cell Tolerance and NF-kappaB

Thursday, February 27 | 8:00AM - 11:00AM
Signaling Systems in Cancer
Room: Grays Peak
NF-kappaB has been implicated in the pathogenesis of many cancers. Its precise role seems to be cancer specific and depends on the contextual network.
Speaker 7 of 7
David A. Barbie, Dana-Farber Cancer Institute, USA
Short Talk: Inhibition of KRAS-Driven Tumorigenicity by Interruption of an Autocrine Cytokine Circuit

Thursday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 27 | 11:00AM - 2:30PM
On Own for Lunch and Recreation


Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: For Highly Innovative, Recent Studies to be Pres
ented
Room: Grays Peak

Speaker 1 of 7
Denis C. Guttridge, Ohio State University, USA
A20 Tumor Suppressor Activity in Sarcomas Is Regulated by a miR-29 Decoy Function on HuR

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: For Highly Innovative, Recent Studies to be Pres
ented
Room: Grays Peak

Speaker 2 of 7
Christina M. Annunziata, NCI, National Institutes of Health, USA
CASPASE 8 Cooperates with IKKbeta to Protect Ovarian Cancer Cells from Necroptosis

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: For Highly Innovative, Recent Studies to be Pres
ented
Room: Grays Peak

Speaker 3 of 7
* Thomas D. Gilmore, Boston University, USA
Evolution of NF-kappaB Signaling

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: For Highly Innovative, Recent Studies to be Pres
ented
Room: Grays Peak

Speaker 4 of 7
William J. Housley, Yale University, USA
Genetic Variants Associated with Multiple Sclerosis Result in Enhanced NF-kappaB Signaling and Responses to Inflammatory Stimuli

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: For Highly Innovative, Recent Studies to be Pres
ented
Room: Grays Peak

Speaker 5 of 7
Barbara Kaltschmidt, Bielefeld University, Germany
A Role of NF-kappaB in Stem Cells

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: For Highly Innovative, Recent Studies to be Pres
ented
Room: Grays Peak

Speaker 6 of 7
Brian C. Schaefer, Uniformed Services University, USA
T Cell Receptor Signals to NF-kappaB Are Transmitted by a Cytosolic p62-Bcl10-Malt1-IKK Signalosome

Thursday, February 27 | 2:30PM - 4:30PM
Workshop 2: For Highly Innovative, Recent Studies to be Pres
ented
Room: Grays Peak

Speaker 7 of 7
Carter Van Waes, NIDCD, National Institutes of Health, USA
Genomic Alterations and Functional Targets in the NF-kappaB and Cell Death Signal Network in Head and Neck Cancer

Thursday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 27 | 5:00PM - 7:00PM
NF-kappaB Systems Pharmacology
Room: Grays Peak
The NF-kappaB signaling system is a critical regulator of many processes and hence a significant drug target. However, its functional pleiotropy harbors risks and regulatory buffering mechanisms pose challenges.
Speaker 1 of 4
Genhong Cheng, University of California, Los Angeles, USA
Gene Programs Involved in the Balance of Pro-Inflammatory and Anti-Inflammatory Responses during Acute and Chronic Infections

Thursday, February 27 | 5:00PM - 7:00PM
NF-kappaB Systems Pharmacology
Room: Grays Peak
The NF-kappaB signaling system is a critical regulator of many processes and hence a significant drug target. However, its functional pleiotropy harbors risks and regulatory buffering mechanisms pose challenges.
Speaker 2 of 4
Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA
IKK Signaling in Cancer and Disease

Thursday, February 27 | 5:00PM - 7:00PM
NF-kappaB Systems Pharmacology
Room: Grays Peak
The NF-kappaB signaling system is a critical regulator of many processes and hence a significant drug target. However, its functional pleiotropy harbors risks and regulatory buffering mechanisms pose challenges.
Speaker 3 of 4
Frank Mercurio, BioTheryX, Inc., USA
Targeting NF-kappaB in the Clinic: Embrace the Complexity

Thursday, February 27 | 5:00PM - 7:00PM
NF-kappaB Systems Pharmacology
Room: Grays Peak
The NF-kappaB signaling system is a critical regulator of many processes and hence a significant drug target. However, its functional pleiotropy harbors risks and regulatory buffering mechanisms pose challenges.
Speaker 4 of 4
Thomas H. Leung, University of Pennsylvania, USA
Short Talk: Topical Hypochlorite Ameliorates NF-kappaB-Mediated Skin Disease in Mice

Thursday, February 27 | 7:00PM - 7:15PM
Concluding Remarks
Room: Grays Peak


Thursday, February 27 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Longs/Quandary Peaks


Thursday, February 27 | 8:00PM - 11:00PM
Entertainment
Room: Longs/Quandary Peaks


Thursday, February 27 | 8:15PM - 11:15PM
Cash Bar
Room: Longs/Quandary Peaks


Friday, February 28 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.