Web Desc
Long Noncoding RNAs: Marching toward Mechanism
Organizer(s): Thomas R. Cech, Edith Heard and Ronald R. Breaker
Date: February 27 - March 04, 2014
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Sponsored by Cell Research and Isis Pharmaceuticals, Inc.
Summary of Meeting:
Much of the mammalian genome is transcribed into long non-coding RNAs, but their biological roles -- such as transcriptional regulation via recruitment of histone-modifying enzymes – are only beginning to be discovered. At the same time, bacterial non-coding RNAs are being found to function as small-molecule-sensing riboswitches and as elements of the CRISPR defense system. For all of these biological systems, a key remaining problem is to understand the detailed mechanism of action. Listing and comparing all of the long ncRNAs, riboswitches, and CRISPR elements genome-wide and among species is useful, but how does the RNA function in each of these systems? The goal of this Keystone Symposium is to stimulate conversations between scientists who work on these very diverse RNA systems, so they can share conceptual frameworks and experimental techniques. This goal will be accomplished by convening an exceptional group of academic and industrial scientists and students to share their insights.
Scholarship Deadline: October 29 2013
Discounted Abstract Deadline: October 29 2013
Abstract Deadline: December 4 2013
Discounted Registration Deadline: January 7 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Cell ResearchIsis Pharmaceuticals, Inc.
We gratefully acknowledge additional support for this conference from:
BioVentures, Inc.Exiqon A/SLandes Bioscience
RaNA Therapeutics
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

RaNA Therapeutics
We gratefully acknowledge the generous grant for this conference provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Grant No. 1R13HD078065-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, February 27 | 4:00PM - 8:00PM
Arrival and Registration
Room: North Concourse


Friday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Friday, February 28 | 8:00AM - 9:00AM
Keynote Address
Room: Anasazi Ballroom

Speaker 1 of 2
* Thomas R. Cech, HHMI/University of Colorado, USA

Friday, February 28 | 8:00AM - 9:00AM
Keynote Address
Room: Anasazi Ballroom

Speaker 2 of 2
Phillip A. Sharp, Massachusetts Institute of Technology, USA
The Synthesis and Functions of Noncoding RNAs

Friday, February 28 | 9:00AM - 11:30AM
Epigenetics and ncRNAs
Room: Anasazi Ballroom

Speaker 1 of 5
Anton Wutz, ETH Zürich, Switzerland
Xist Induced Chromatin Modifications in Development and Embryonic Stem Cells

Friday, February 28 | 9:00AM - 11:30AM
Epigenetics and ncRNAs
Room: Anasazi Ballroom

Speaker 2 of 5
Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA
X-Chromosome Inactivation: A Model to Study Epigenetic Regulation by Long Noncoding RNA

Friday, February 28 | 9:00AM - 11:30AM
Epigenetics and ncRNAs
Room: Anasazi Ballroom

Speaker 3 of 5
Alena Shkumatava, Institut Curie-Centre de Recherche, France
Conserved Functions of lincRNAs in Vertebrate Development

Friday, February 28 | 9:00AM - 11:30AM
Epigenetics and ncRNAs
Room: Anasazi Ballroom

Speaker 4 of 5
Igor Ulitsky, Weizmann Institute of Science, Israel
Short Talk: Common and Distinct Features of Short Translated ORFs in lincRNAs and 5'UTRs

Friday, February 28 | 9:00AM - 11:30AM
Epigenetics and ncRNAs
Room: Anasazi Ballroom

Speaker 5 of 5
Olga Villamizar, Southern Illinois University School of Medicine, USA
Short Talk: LncRNA Saf Interacts with SPF45 to Promote Alternative-Splicing of Fas Receptor Pre-mRNA and Resistance to Apoptosis

Friday, February 28 | 9:40AM - 10:00AM
Coffee Break
Room: Zia Concourse


Friday, February 28 | 11:30AM - 1:00PM
Poster Setup
Room: Sunset Room/Eldorado Court


Friday, February 28 | 11:30AM - 5:00PM
On Own for Lunch and Recreation


Friday, February 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room/Eldorado Court


Friday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Friday, February 28 | 5:00PM - 7:00PM
ncRNAs and Transcriptional Control
Room: Anasazi Ballroom

Speaker 1 of 5
* John L. Rinn, University of Colorado Boulder, USA

Friday, February 28 | 5:00PM - 7:00PM
ncRNAs and Transcriptional Control
Room: Anasazi Ballroom

Speaker 2 of 5
Danny F. Reinberg, HHMI/New York University, USA
Histone Modification and Long ncRNAs

Friday, February 28 | 5:00PM - 7:00PM
ncRNAs and Transcriptional Control
Room: Anasazi Ballroom

Speaker 3 of 5
Ingrid Grummt, German Cancer Research Center, Germany
rRNA Regulation by ncRNAs

Friday, February 28 | 5:00PM - 7:00PM
ncRNAs and Transcriptional Control
Room: Anasazi Ballroom

Speaker 4 of 5
Edith Heard, European Molecular Biology Laboratory, Germany
X-Chromosome Inactivation: A Paradigm of Epigenetic Regulation via Noncoding RNA

Friday, February 28 | 5:00PM - 7:00PM
ncRNAs and Transcriptional Control
Room: Anasazi Ballroom

Speaker 5 of 5
Céline Vallot, UMR 7216-Centre National de la Recherche Scientifique, France
Short Talk: XACT – a Supportive Coat for X-Chromosome Activity in Human?

Friday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Friday, February 28 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunset Room/Eldorado Court


Saturday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Saturday, March 01 | 7:30AM - 8:00AM
Poster Setup
Room: Sunset Room/Eldorado Court


Saturday, March 01 | 8:00AM - 7:00PM
Poster Viewing
Room: Sunset Room/Eldorado Court


Saturday, March 01 | 8:00AM - 11:00AM
Bacterial ncRNAs
Room: Anasazi Ballroom

Speaker 1 of 6
* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA

Saturday, March 01 | 8:00AM - 11:00AM
Bacterial ncRNAs
Room: Anasazi Ballroom

Speaker 2 of 6
Ronald R. Breaker, Yale University, USA
Large ncRNAs in Bacteria

Saturday, March 01 | 8:00AM - 11:00AM
Bacterial ncRNAs
Room: Anasazi Ballroom

Speaker 3 of 6
Gisela T. Storz, National Institutes of Health, USA
Dual Function Regulatory RNAs in Bacteria

Saturday, March 01 | 8:00AM - 11:00AM
Bacterial ncRNAs
Room: Anasazi Ballroom

Speaker 4 of 6
Karen M. Wassarman, University of Wisconsin-Madison, USA
6S RNA in E. coli, B. subtilis, and Beyond . . .

Saturday, March 01 | 8:00AM - 11:00AM
Bacterial ncRNAs
Room: Anasazi Ballroom

Speaker 5 of 6
James W. Nelson, Yale University, USA
Short Talk: Riboswitch Receptors for Bacterial Second Messengers

Saturday, March 01 | 8:00AM - 11:00AM
Bacterial ncRNAs
Room: Anasazi Ballroom

Speaker 6 of 6
Thomas Hermann, University of California, San Diego, USA
Short Talk: A Guanine-Triggered Conformational Switch in a Highly Conserved Domain of the Hepatitis C Virus IRES

Saturday, March 01 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Saturday, March 01 | 11:00AM - 12:00PM
Lunch
Room: Sunset Room/Eldorado Court


Saturday, March 01 | 12:00PM - 2:30PM
Poster Session 2
Room: Sunset Room/Eldorado Court


Saturday, March 01 | 2:30PM - 4:30PM
Workshop 1: LincRNAs in Differentiation and Development
Room: Anasazi Ballroom

Speaker 1 of 7
* Ingrid Grummt, German Cancer Research Center, Germany

Saturday, March 01 | 2:30PM - 4:30PM
Workshop 1: LincRNAs in Differentiation and Development
Room: Anasazi Ballroom

Speaker 2 of 7
Federico D. Ariel, Institut des Sciences du Végétal, France
Noncoding Transcription by Alternative RNA Polymerases Regulates Chromatin Loop Dynamics

Saturday, March 01 | 2:30PM - 4:30PM
Workshop 1: LincRNAs in Differentiation and Development
Room: Anasazi Ballroom

Speaker 3 of 7
Riki Kurokawa, Saitama Medical University, Japan
Mechanism of Transcription of Long Noncoding RNA

Saturday, March 01 | 2:30PM - 4:30PM
Workshop 1: LincRNAs in Differentiation and Development
Room: Anasazi Ballroom

Speaker 4 of 7
Ezgi Hacisuleyman, Harvard University, USA
Topological Organization of Multi-Chromosomal Regions by Firre

Saturday, March 01 | 2:30PM - 4:30PM
Workshop 1: LincRNAs in Differentiation and Development
Room: Anasazi Ballroom

Speaker 5 of 7
Nianwei Lin, Sanford-Burnham Medical Research Institute, USA
An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment

Saturday, March 01 | 2:30PM - 4:30PM
Workshop 1: LincRNAs in Differentiation and Development
Room: Anasazi Ballroom

Speaker 6 of 7
Matthew G. Schwartz, Harvard Medical School, USA
The Role of Long Noncoding RNAs in Regulating Chicken Limb Patterning

Saturday, March 01 | 2:30PM - 4:30PM
Workshop 1: LincRNAs in Differentiation and Development
Room: Anasazi Ballroom

Speaker 7 of 7
H. Scott Stadler, Shriners Hospital, Oregon Health & Science University, USA
The Novel Long Noncoding RNA, Hotchon, Regulates Chondrogenic Programming in Limb Mesenchyme and Mesenchymal Stem Cells

Saturday, March 01 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Saturday, March 01 | 5:00PM - 7:00PM
Riboswitches and CRISPR
Room: Anasazi Ballroom

Speaker 1 of 5
* Ronald R. Breaker, Yale University, USA

Saturday, March 01 | 5:00PM - 7:00PM
Riboswitches and CRISPR
Room: Anasazi Ballroom

Speaker 2 of 5
Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
RNA-Guided Genome Defense and Engineering by CRISPR Systems

Saturday, March 01 | 5:00PM - 7:00PM
Riboswitches and CRISPR
Room: Anasazi Ballroom

Speaker 3 of 5
Samuel H. Sternberg, Columbia University, USA
Short Talk: DNA Interrogation by the CRISPR RNA-Guided Endonuclease Cas9

Saturday, March 01 | 5:00PM - 7:00PM
Riboswitches and CRISPR
Room: Anasazi Ballroom

Speaker 4 of 5
Beatrix Suess, Technical University Darmstadt, Germany
Mechanistic Insights into Engineered Riboswitches

Saturday, March 01 | 5:00PM - 7:00PM
Riboswitches and CRISPR
Room: Anasazi Ballroom

Speaker 5 of 5
Robert T. Batey, University of Colorado, Boulder, USA
Structure and Mechanism of Bacterial Cobalamin Riboswitches


Saturday, March 01 | 7:00PM - 7:00PM
On Own for Dinner


Sunday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Sunday, March 02 | 8:00AM - 11:00AM
RNA Methods, Diagnostics and Therapeutics
Room: Anasazi Ballroom

Speaker 1 of 6
* Anna Marie Pyle, Yale University, USA

Sunday, March 02 | 8:00AM - 11:00AM
RNA Methods, Diagnostics and Therapeutics
Room: Anasazi Ballroom

Speaker 2 of 6
Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs

Sunday, March 02 | 8:00AM - 11:00AM
RNA Methods, Diagnostics and Therapeutics
Room: Anasazi Ballroom

Speaker 3 of 6
Larry Gold, SomaLogic Inc., USA
Nucleic Acid SOMAmers for Diagnostics and Therapeutics

Sunday, March 02 | 8:00AM - 11:00AM
RNA Methods, Diagnostics and Therapeutics
Room: Anasazi Ballroom

Speaker 4 of 6
Bruce A. Sullenger, Duke University, USA
Clinical Applications of Antithrombotic Noncoding RNAs

Sunday, March 02 | 8:00AM - 11:00AM
RNA Methods, Diagnostics and Therapeutics
Room: Anasazi Ballroom

Speaker 5 of 6
Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA

Sunday, March 02 | 8:00AM - 11:00AM
RNA Methods, Diagnostics and Therapeutics
Room: Anasazi Ballroom

Speaker 6 of 6
Ming Lei, Institute of Biochemistry and Cell Biology, China
Structural Basis for Protein-RNA Recognition in Telomerase

Sunday, March 02 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Sunday, March 02 | 11:15AM - 1:00PM
Poster Setup
Room: Sunset Room/Eldorado Court


Sunday, March 02 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Sunday, March 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room/Eldorado Court


Sunday, March 02 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Sunday, March 02 | 5:00PM - 7:00PM
Catalytic RNAs and RNPs
Room: Anasazi Ballroom

Speaker 1 of 5
* Lara Szewczak, Cell Press, USA

Sunday, March 02 | 5:00PM - 7:00PM
Catalytic RNAs and RNPs
Room: Anasazi Ballroom

Speaker 2 of 5
Anna Marie Pyle, Yale University, USA
Structure Determination and Functional Analysis of Long Intergenic Noncoding RNAs (lincRNAs)

Sunday, March 02 | 5:00PM - 7:00PM
Catalytic RNAs and RNPs
Room: Anasazi Ballroom

Speaker 3 of 5
Peter Baumann, HHMI/Stowers Institute for Medical Research, USA
Telomerase Biogenesis and Regulation

Sunday, March 02 | 5:00PM - 7:00PM
Catalytic RNAs and RNPs
Room: Anasazi Ballroom

Speaker 4 of 5
Joachim Lingner, École Polytechnique Fédérale de Lausanne, Switzerland
Telomere Functions of TERRA ncRNA

Sunday, March 02 | 5:00PM - 7:00PM
Catalytic RNAs and RNPs
Room: Anasazi Ballroom

Speaker 5 of 5
Isabel López de Silanes, Spanish National Cancer Research Centre, Spain
Short Talk: Identification of the Subtelomeric Sequence of the Long Noncoding RNA TERRA Unveils its Role at Telomeres

Sunday, March 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Sunday, March 02 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunset Room/Eldorado Court


Monday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Monday, March 03 | 8:00AM - 11:00AM
Genome-Wide Analysis
Room: Anasazi Ballroom

Speaker 1 of 7
* Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA

Monday, March 03 | 8:00AM - 11:00AM
Genome-Wide Analysis
Room: Anasazi Ballroom

Speaker 2 of 7
John L. Rinn, University of Colorado Boulder, USA
Linking RNA to Cellular Differentiation

Monday, March 03 | 8:00AM - 11:00AM
Genome-Wide Analysis
Room: Anasazi Ballroom

Speaker 3 of 7
Nicholas Ingolia, University of California, Berkeley, USA
Exploring Translation Outside of Canonical Protein Coding Region with Ribosome Profiling

Monday, March 03 | 8:00AM - 11:00AM
Genome-Wide Analysis
Room: Anasazi Ballroom

Speaker 4 of 7
Thomas R. Gingeras, Cold Spring Harbor Laboratory, USA
RNA Based Communication Inside and Outside Cells

Monday, March 03 | 8:00AM - 11:00AM
Genome-Wide Analysis
Room: Anasazi Ballroom

Speaker 5 of 7
Julia Questa, John Innes Centre, UK
Linking Antisense RNA and Chromatin in Flowering Control

Monday, March 03 | 8:00AM - 11:00AM
Genome-Wide Analysis
Room: Anasazi Ballroom

Speaker 6 of 7
Crystal Zhao, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: N6-Methyladenosine Modification Destabilizes Developmental Regulators in Embryonic Stem Cells

Monday, March 03 | 8:00AM - 11:00AM
Genome-Wide Analysis
Room: Anasazi Ballroom

Speaker 7 of 7
Alexandra Lusser, Innsbruck Medical University, Austria
Short Talk: Identification and Characterization of Cytosine Methylation in Mammalian lncRNAs

Monday, March 03 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Monday, March 03 | 11:00AM - 2:30PM
On Own for Lunch and Recreation


Monday, March 03 | 2:30PM - 4:30PM
Workshop 2: Emerging Technologies for LncRNA Research
Room: Anasazi Ballroom

Speaker 1 of 9
* Howard Y. Chang, Stanford University, USA

Monday, March 03 | 2:30PM - 4:30PM
Workshop 2: Emerging Technologies for LncRNA Research
Room: Anasazi Ballroom

Speaker 2 of 9
Timothy G. Johnstone, Yale University School of Medicine, USA
Ribosome Footprinting Defines the Coding Potential of the Vertebrate Genome

Monday, March 03 | 2:30PM - 4:30PM
Workshop 2: Emerging Technologies for LncRNA Research
Room: Anasazi Ballroom

Speaker 3 of 9
Amanda Birmingham, Dharmacon, GE Healthcare, USA
Targeting and Off-Targeting of Long Non-Coding RNAs by siRNAs

Monday, March 03 | 2:30PM - 4:30PM
Workshop 2: Emerging Technologies for LncRNA Research
Room: Anasazi Ballroom

Speaker 4 of 9
Moran Nataly Cabili, Harvard and The Broad Institute, USA
A Single Molecule, single Cell RNA Localization Catalog Reveals Abundance and
Cellular Localization Patterns of lincRNAs


Monday, March 03 | 2:30PM - 4:30PM
Workshop 2: Emerging Technologies for LncRNA Research
Room: Anasazi Ballroom

Speaker 5 of 9
Lalith S. Gunawardane, Case Western Reserve University, USA
Analysis of the Interactome of a Long Non-Coding RNA: lncRNA-Protein Interactions Capture by AntiSense Oligonucleotides (lncRNA- PICASO)

Monday, March 03 | 2:30PM - 4:30PM
Workshop 2: Emerging Technologies for LncRNA Research
Room: Anasazi Ballroom

Speaker 6 of 9
Liangliang Hao, MIT, USA
Spherical Nucleic Acids for Noncoding RNA Therapeutics

Monday, March 03 | 2:30PM - 4:30PM
Workshop 2: Emerging Technologies for LncRNA Research
Room: Anasazi Ballroom

Speaker 7 of 9
Peter Mouritzen, Exiqon, Denmark
Efficient Silencing of lncRNA with LNA™ Antisense Oligonucleotides

Monday, March 03 | 2:30PM - 4:30PM
Workshop 2: Emerging Technologies for LncRNA Research
Room: Anasazi Ballroom

Speaker 8 of 9
Mitchell R. O'Connell, University of Rochester Medical Center, USA
Programmable RNA Targeting and Cleavage by CRISPR/Cas9 Enzymes

Monday, March 03 | 2:30PM - 4:30PM
Workshop 2: Emerging Technologies for LncRNA Research
Room: Anasazi Ballroom

Speaker 9 of 9
Karissa Y. Sanbonmatsu, Los Alamos National Laboratory, USA
Structural Studies of Intact Long Noncoding RNAs in Plants and Mammals

Monday, March 03 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Monday, March 03 | 5:00PM - 7:00PM
Long ncRNAs and Chromatin
Room: Anasazi Ballroom

Speaker 1 of 6
* Edith Heard, European Molecular Biology Laboratory, Germany

Monday, March 03 | 5:00PM - 7:00PM
Long ncRNAs and Chromatin
Room: Anasazi Ballroom

Speaker 2 of 6
Chen Davidovich, Monash University, Australia
Short Talk: Promiscuous RNA Binding by PRC2: A Model for Scanning through Active Genes and Maintaining Repressed Chromatin

Monday, March 03 | 5:00PM - 7:00PM
Long ncRNAs and Chromatin
Room: Anasazi Ballroom

Speaker 3 of 6
Thomas R. Cech, HHMI/University of Colorado, USA
Cooperative RNA Binding by FUS Nucleates Higher-Order Protein Assemblies

Monday, March 03 | 5:00PM - 7:00PM
Long ncRNAs and Chromatin
Room: Anasazi Ballroom

Speaker 4 of 6
Lawrence J. Hayward, University of Massachusetts Medical School, USA
Short Talk: Transgenic Mouse Models of FUS/TLS-Mediated ALS

Monday, March 03 | 5:00PM - 7:00PM
Long ncRNAs and Chromatin
Room: Anasazi Ballroom

Speaker 5 of 6
Daniel H. Kim, California Institute of Technology, USA
Short Talk: Single-Cell Transcriptome Analysis of Long Noncoding RNAs during Cellular Reprogramming

Monday, March 03 | 5:00PM - 7:00PM
Long ncRNAs and Chromatin
Room: Anasazi Ballroom

Speaker 6 of 6
Mridula (Millie) K. Ray, Harvard University, Massachusetts General Hospital, USA
Short Talk: lncRNAs Interact with PRC1 to Impact PcG Gene-Regulatory Networks

Monday, March 03 | 7:00PM - 7:15PM
Closing Comments
Room: Anasazi Ballroom

Speaker 1 of 3
Ronald R. Breaker, Yale University, USA

Monday, March 03 | 7:00PM - 7:15PM
Closing Comments
Room: Anasazi Ballroom

Speaker 2 of 3
Edith Heard, European Molecular Biology Laboratory, Germany

Monday, March 03 | 7:00PM - 7:15PM
Closing Comments
Room: Anasazi Ballroom

Speaker 3 of 3
Thomas R. Cech, HHMI/University of Colorado, USA

Monday, March 03 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Monday, March 03 | 8:00PM - 11:00PM
Entertainment
Room: Eldorado Court/Sunset Room


Monday, March 03 | 8:15PM - 11:00PM
Cash Bar
Room: Eldorado Court/Sunset Room


Tuesday, March 04 | 10:25AM - 10:25AM
Departure


*Session Chair.