Web Desc
Cilia, Development and Human Disease
Organizer(s): Elizabeth Petri Henske, Jeremy F. Reiter and Joel Rosenbaum
Date: March 02 - 07, 2014
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by the Directors' Fund
Summary of Meeting:
Our understanding of the cilium and ciliary-based signaling continue to rapidly advance, providing novel insights into diseases in which ciliary defects appear to play a dominant role in disease initiation ('ciliopathies'), as well as diseases such as cancer in which ciliary defects appear to play a critical role in disease progression. Increasingly, an understanding of ciliary disease mechanisms is leading to novel therapeutic strategies. This Keystone Symposia meeting brings together leaders in basic mechanisms, translational research, and clinical research, with the objective of bridging the gaps between basic discovery and human disease.
Scholarship Deadline: November 4 2013
Discounted Abstract Deadline: November 4 2013
Abstract Deadline: December 4 2013
Discounted Registration Deadline: January 7 2014
We gratefully acknowledge additional support for this conference from:
March of Dimes Foundation Grant No. 4-FY14-469
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
EMBO (European Molecular Biology Organization)
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK101223-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 02 | 4:00PM - 8:00PM
Arrival and Registration
Room: Pre Function


Sunday, March 02 | 6:00PM - 8:00PM
Light Meal - Provided by Granlibakken
Room: Granhall


Monday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, March 03 | 8:00AM - 9:00AM
Keynote Address
Room: Mountain/Lake

Speaker 1 of 1
Kathryn V. Anderson, Memorial Sloan-Kettering Cancer Center, USA
Regulation of Cilia Structure and Cilia Formation during Mouse Development

Monday, March 03 | 9:00AM - 11:30AM
Ciliary Structure, Formation and Resorption
Room: Mountain/Lake

Speaker 1 of 7
* Joel Rosenbaum, Yale University, USA

Monday, March 03 | 9:00AM - 11:30AM
Ciliary Structure, Formation and Resorption
Room: Mountain/Lake

Speaker 2 of 7
* Bradley K. Yoder, University of Alabama at Birmingham, USA

Monday, March 03 | 9:00AM - 11:30AM
Ciliary Structure, Formation and Resorption
Room: Mountain/Lake

Speaker 3 of 7
Wallace Marshall, University of California, San Francisco, USA
The Flagellar Length Control System

Monday, March 03 | 9:00AM - 11:30AM
Ciliary Structure, Formation and Resorption
Room: Mountain/Lake

Speaker 4 of 7
Paul A. Lefebvre, University of Minnesota, USA
The Role of Flagellar and Cytoplasmic Protein Kinases in the Control of Flagellar Length in Chlamydomonas

Monday, March 03 | 9:00AM - 11:30AM
Ciliary Structure, Formation and Resorption
Room: Mountain/Lake

Speaker 5 of 7
Cheryl L. Walker, Baylor College of Medicine, USA
Targeting of Aurora Kinase A (AURKA) by the von Hippel-Lindau (VHL) Tumor Suppressor in Maintenance of the Primary Cilia

Monday, March 03 | 9:00AM - 11:30AM
Ciliary Structure, Formation and Resorption
Room: Mountain/Lake

Speaker 6 of 7
Christine Insinna Kettenhofen, NCI-Frederick National Laboratory, USA
Short Talk: EHD and Rab Proteins Coordinate the Initiation of Ciliary Membrane Assembly

Monday, March 03 | 9:00AM - 11:30AM
Ciliary Structure, Formation and Resorption
Room: Mountain/Lake

Speaker 7 of 7
Mustafa k. Khokha, Yale University, USA
Short Talk: The Heterotaxy Gene, GALNT11, Glycosylates Notch to Orchestrate Cilia Type and Laterality

Monday, March 03 | 9:40AM - 10:00AM
Coffee Break
Room: Pre Function


Monday, March 03 | 11:30AM - 1:00PM
Poster Setup
Room: Bay


Monday, March 03 | 11:30AM - 5:00PM
On Own for Lunch and Recreation


Monday, March 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, March 03 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, March 03 | 5:00PM - 6:45PM
Left-Right Patterning and Hedgehog Signaling
Room: Mountain/Lake

Speaker 1 of 5
* Gregory J. Pazour, University of Massachusetts Medical School, USA

Monday, March 03 | 5:00PM - 6:45PM
Left-Right Patterning and Hedgehog Signaling
Room: Mountain/Lake

Speaker 2 of 5
* Michael J. Caplan, Yale University, USA

Monday, March 03 | 5:00PM - 6:45PM
Left-Right Patterning and Hedgehog Signaling
Room: Mountain/Lake

Speaker 3 of 5
Bradley K. Yoder, University of Alabama at Birmingham, USA
A Role for the Mammalian DRC Protein Gas8 in Left-Right Asymmetry and Cilia Motility

Monday, March 03 | 5:00PM - 6:45PM
Left-Right Patterning and Hedgehog Signaling
Room: Mountain/Lake

Speaker 4 of 5
Yingzi Yang, Harvard School of Dental Medicine, USA
Planar Cell Polarity of Node Cells and Symmetry Breaking

Monday, March 03 | 5:00PM - 6:45PM
Left-Right Patterning and Hedgehog Signaling
Room: Mountain/Lake

Speaker 5 of 5
Bomi Jung, Institute of Diabetes and Regeneration, Germany
Short Talk: Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation

Monday, March 03 | 6:45PM - 7:45PM
Dinner
Room: Granhall


Monday, March 03 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay


Monday, March 03 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Tuesday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, March 04 | 8:00AM - 11:15AM
Vesicle Transport and Trafficking
Room: Mountain/Lake

Speaker 1 of 8
* Jean Bennett, University of Pennsylvania, USA

Tuesday, March 04 | 8:00AM - 11:15AM
Vesicle Transport and Trafficking
Room: Mountain/Lake

Speaker 2 of 8
* Michel R. Leroux, Simon Fraser University, Canada

Tuesday, March 04 | 8:00AM - 11:15AM
Vesicle Transport and Trafficking
Room: Mountain/Lake

Speaker 3 of 8
Peter K. Jackson, Stanford University, USA
Linking Cilia to Insulin Signaling in Preadipocytes

Tuesday, March 04 | 8:00AM - 11:15AM
Vesicle Transport and Trafficking
Room: Mountain/Lake

Speaker 4 of 8
Oliver Blacque, University College Dublin, Ireland
New Transport Regulators at Cilia Base

Tuesday, March 04 | 8:00AM - 11:15AM
Vesicle Transport and Trafficking
Room: Mountain/Lake

Speaker 5 of 8
Gregory J. Pazour, University of Massachusetts Medical School, USA
IFT25 and IFT27 Are Required for Maintenance of the Ciliary Signaling Compartment

Tuesday, March 04 | 8:00AM - 11:15AM
Vesicle Transport and Trafficking
Room: Mountain/Lake

Speaker 6 of 8
Markus Delling, University of California, San Francisco, USA
The Primary Cilium is a Specialized Calcium Signaling Organelle

Tuesday, March 04 | 8:00AM - 11:15AM
Vesicle Transport and Trafficking
Room: Mountain/Lake

Speaker 7 of 8
Ellen J. Ezratty, Rockefeller University, USA
Short Talk: An Emerging Role for Arl/Arf Family GTPases in Regulation of Cilia Function during Notch Signaling and Epidermal Differentiation

Tuesday, March 04 | 8:00AM - 11:15AM
Vesicle Transport and Trafficking
Room: Mountain/Lake

Speaker 8 of 8
John A. Martignetti, Mount Sinai School of Medicine, USA
Short Talk: Inactivation of the Ciliary Protein CEP19 Results in a Novel Morbid Obesity Syndrome in Humans and Mice

Tuesday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Tuesday, March 04 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, March 04 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, March 04 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, March 04 | 5:00PM - 7:00PM
Therapeutic Advances in Treating Ciliopathies
Room: Mountain/Lake

Speaker 1 of 5
* Elizabeth Petri Henske, Brigham and Women's Hospital, USA

Tuesday, March 04 | 5:00PM - 7:00PM
Therapeutic Advances in Treating Ciliopathies
Room: Mountain/Lake

Speaker 2 of 5
Jean Bennett, University of Pennsylvania, USA
Ciliopathies Causing Blindness as Gene Therapy Targets: Progress and Prospects

Tuesday, March 04 | 5:00PM - 7:00PM
Therapeutic Advances in Treating Ciliopathies
Room: Mountain/Lake

Speaker 3 of 5
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
The Dual Interplay between Ciliogenesis and Autophagy

Tuesday, March 04 | 5:00PM - 7:00PM
Therapeutic Advances in Treating Ciliopathies
Room: Mountain/Lake

Speaker 4 of 5
Frederic J. de Sauvage, Genentech, Inc., USA
Innate and Acquired Resistance to Hedgehog Pathways Inhibitors

Tuesday, March 04 | 5:00PM - 7:00PM
Therapeutic Advances in Treating Ciliopathies
Room: Mountain/Lake

Speaker 5 of 5
Ching-Hwa Sung, Cornell University, USA
Short Talk: Light Regulates the Ciliary Protein Transport and Outer Segment Disc Renewal of Mammalian Photoreceptors

Tuesday, March 04 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, March 04 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay


Tuesday, March 04 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Wednesday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, March 05 | 8:00AM - 11:15AM
Cilia, Proliferation and Cancer
Room: Mountain/Lake

Speaker 1 of 7
* Cheryl L. Walker, Baylor College of Medicine, USA

Wednesday, March 05 | 8:00AM - 11:15AM
Cilia, Proliferation and Cancer
Room: Mountain/Lake

Speaker 2 of 7
Elizabeth Petri Henske, Brigham and Women's Hospital, USA
Cilia and the Pathogenesis of Tuberous Sclerosis Complex

Wednesday, March 05 | 8:00AM - 11:15AM
Cilia, Proliferation and Cancer
Room: Mountain/Lake

Speaker 3 of 7
Jeremy F. Reiter, University of California, San Francisco, USA
Do Cilia Participate in Common Diseases?

Wednesday, March 05 | 8:00AM - 11:15AM
Cilia, Proliferation and Cancer
Room: Mountain/Lake

Speaker 4 of 7
Brian D. Dynlacht, New York University School of Medicine, USA
Regulation of the Centrosome-Cilium Cycle

Wednesday, March 05 | 8:00AM - 11:15AM
Cilia, Proliferation and Cancer
Room: Mountain/Lake

Speaker 5 of 7
Erica A. Golemis, Fox Chase Cancer Center, USA
Probing the Relationship between Cilia and Cystogenesis in Models of ADPKD

Wednesday, March 05 | 8:00AM - 11:15AM
Cilia, Proliferation and Cancer
Room: Mountain/Lake

Speaker 6 of 7
Mattias Alenius, Linkoping University, Sweden
Short Talk: Cilia-Mediated Hedgehog Signaling in Drosophila

Wednesday, March 05 | 8:00AM - 11:15AM
Cilia, Proliferation and Cancer
Room: Mountain/Lake

Speaker 7 of 7
Daniel B. Constam, École Polytechnique Fédérale de Lausanne, Switzerland
Short Talk: Regulation of Bicc1-Mediated mRNA Silencing by Calcium

Wednesday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Wednesday, March 05 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Wednesday, March 05 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Wednesday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Wednesday, March 05 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, March 05 | 5:00PM - 7:15PM
Cystic Disease
Room: Mountain/Lake

Speaker 1 of 7
* Erica A. Golemis, Fox Chase Cancer Center, USA

Wednesday, March 05 | 5:00PM - 7:15PM
Cystic Disease
Room: Mountain/Lake

Speaker 2 of 7
* Jeremy F. Reiter, University of California, San Francisco, USA

Wednesday, March 05 | 5:00PM - 7:15PM
Cystic Disease
Room: Mountain/Lake

Speaker 3 of 7
Friedhelm Hildebrandt, Howard Hughes Medical Institute and Boston Children’s Hospital, USA
DNA Damage Response Signaling in Ciliopathies

Wednesday, March 05 | 5:00PM - 7:15PM
Cystic Disease
Room: Mountain/Lake

Speaker 4 of 7
Michael J. Caplan, Yale University, USA
The Polycystins and Ciliary Sensing

Wednesday, March 05 | 5:00PM - 7:15PM
Cystic Disease
Room: Mountain/Lake

Speaker 5 of 7
Kimberly M. McDermott, Kimberly McDermott Coaching, USA
Investigating the Role of Primary Cilia in Hedgehog Pathway Drug Resistance

Wednesday, March 05 | 5:00PM - 7:15PM
Cystic Disease
Room: Mountain/Lake

Speaker 6 of 7
Sandra Hakim, Monash University, Australia
Short Talk: Inpp5e Regulates Cilia and mTOR Signaling in Renal Epithelial Cells to Suppress Polycystic Kidney Disease

Wednesday, March 05 | 5:00PM - 7:15PM
Cystic Disease
Room: Mountain/Lake

Speaker 7 of 7
Rannar Airik, Boston Children’s Hospital, USA
Short Talk: Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response signaling

Wednesday, March 05 | 7:15PM - 8:15PM
Dinner
Room: Granhall


Wednesday, March 05 | 7:30PM - 10:00PM
Poster Session 3
Room: Bay


Wednesday, March 05 | 8:00PM - 9:00PM
Social Hour
Room: Bay


Thursday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, March 06 | 8:00AM - 11:00AM
Signaling to and from the Cilium
Room: Mountain/Lake

Speaker 1 of 7
* Kathryn V. Anderson, Memorial Sloan-Kettering Cancer Center, USA

Thursday, March 06 | 8:00AM - 11:00AM
Signaling to and from the Cilium
Room: Mountain/Lake

Speaker 2 of 7
Adrian Salic, Harvard Medical School, USA
Hedgehogs and Sterols

Thursday, March 06 | 8:00AM - 11:00AM
Signaling to and from the Cilium
Room: Mountain/Lake

Speaker 3 of 7
Philip A. Beachy, HHMI/Stanford University, USA
Hedgehog Signaling, Cilia and Cancer

Thursday, March 06 | 8:00AM - 11:00AM
Signaling to and from the Cilium
Room: Mountain/Lake

Speaker 4 of 7
Tao P. Zhong, East China Normal University, China
Short Talk; Prostaglandin Signaling Regulates Ciliogenesis through Modulating Intraflagellar Transport

Thursday, March 06 | 8:00AM - 11:00AM
Signaling to and from the Cilium
Room: Mountain/Lake

Speaker 5 of 7
Elle C. Roberson, University of California, San Francisco, USA
Short Talk: Tmem231 is a Ciliopathy Protein Required for Ciliary Membrane Protein Composition

Thursday, March 06 | 8:00AM - 11:00AM
Signaling to and from the Cilium
Room: Mountain/Lake

Speaker 6 of 7
Ruhee Dere, Baylor College of Medicine, USA
Short Talk: Aurora Kinase A (AURKA) Inhibition Rescues Renal Cystogenesis, Independent of mTORC1 Activation, in a Ciliopathy Model of Tsc2

Thursday, March 06 | 8:00AM - 11:00AM
Signaling to and from the Cilium
Room: Mountain/Lake

Speaker 7 of 7
* Cosima T. Baldari, University of Siena, Italy
Short Talk: The Atypical Rab GTPase, Rab29, Is a Common Regulator of Immune Synapse Assembly and Ciliogenesis

Thursday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Thursday, March 06 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Thursday, March 06 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Thursday, March 06 | 5:00PM - 7:00PM
Protein Localization to Cilia
Room: Mountain/Lake

Speaker 1 of 5
* Kimberly M. McDermott, Kimberly McDermott Coaching, USA

Thursday, March 06 | 5:00PM - 7:00PM
Protein Localization to Cilia
Room: Mountain/Lake

Speaker 2 of 5
Michel R. Leroux, Simon Fraser University, Canada
Formation and Function of the Transition Zone, a Ciliary Gate

Thursday, March 06 | 5:00PM - 7:00PM
Protein Localization to Cilia
Room: Mountain/Lake

Speaker 3 of 5
* Kristen Verhey, University of Michigan, USA
Regulating Entry into the Ciliary Compartment

Thursday, March 06 | 5:00PM - 7:00PM
Protein Localization to Cilia
Room: Mountain/Lake

Speaker 4 of 5
Stefan Somlo, Yale School of Medicine, USA
Polycystic Kidney and Liver Diseases: From Gene Discovery to Mechanism

Thursday, March 06 | 5:00PM - 7:00PM
Protein Localization to Cilia
Room: Mountain/Lake

Speaker 5 of 5
Ahmet Yildiz, University of California, Berkeley, USA
Short Talk: Direct Observation of IFT Turnover at the Flagellar Tip and Base using the Photobleaching Gate Assay

Thursday, March 06 | 7:00PM - 7:15PM
Closing Remarks
Room: Mountain/Lake

Speaker 1 of 3
Elizabeth Petri Henske, Brigham and Women's Hospital, USA

Thursday, March 06 | 7:00PM - 7:15PM
Closing Remarks
Room: Mountain/Lake

Speaker 2 of 3
Jeremy F. Reiter, University of California, San Francisco, USA

Thursday, March 06 | 7:00PM - 7:15PM
Closing Remarks
Room: Mountain/Lake

Speaker 3 of 3
Joel Rosenbaum, Yale University, USA

Thursday, March 06 | 7:15PM - 8:15PM
Dinner
Room: Granhall


Thursday, March 06 | 7:15PM - 8:15PM
Social Hour
Room: Granhall


Thursday, March 06 | 8:00PM - 11:00PM
Entertainment
Room: Granhall


Thursday, March 06 | 8:15PM - 11:00PM
Cash Bar
Room: Granhall


Friday, March 07 | 10:25AM - 10:25AM
Departure


*Session Chair.