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Web Desc
Cilia, Development and Human Disease Organizer(s): Elizabeth Petri Henske, Jeremy F. Reiter and Joel Rosenbaum Date: March 02 - 07, 2014 Location: Granlibakken Tahoe, Tahoe City, CA, USA Supported by the Directors' Fund Summary of Meeting: Our understanding of the cilium and ciliary-based signaling continue to rapidly advance, providing novel insights into diseases in which ciliary defects appear to play a dominant role in disease initiation ('ciliopathies'), as well as diseases such as cancer in which ciliary defects appear to play a critical role in disease progression. Increasingly, an understanding of ciliary disease mechanisms is leading to novel therapeutic strategies. This Keystone Symposia meeting brings together leaders in basic mechanisms, translational research, and clinical research, with the objective of bridging the gaps between basic discovery and human disease. Scholarship Deadline: November 4 2013 Discounted Abstract Deadline: November 4 2013 Abstract Deadline: December 4 2013 Discounted Registration Deadline: January 7 2014 We gratefully acknowledge additional support for this conference from: We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Grant No. 1R13DK101223-01 The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Cilia, Development and Human Disease

Organizer(s): Elizabeth Petri Henske, Jeremy F. Reiter and Joel Rosenbaum

Date: March 02 - 07, 2014
Location: Granlibakken Tahoe, Tahoe City, CA, USA

Supported by the Directors' Fund

Summary of Meeting:

Our understanding of the cilium and ciliary-based signaling continue to rapidly advance, providing novel insights into diseases in which ciliary defects appear to play a dominant role in disease initiation ('ciliopathies'), as well as diseases such as cancer in which ciliary defects appear to play a critical role in disease progression. Increasingly, an understanding of ciliary disease mechanisms is leading to novel therapeutic strategies. This Keystone Symposia meeting brings together leaders in basic mechanisms, translational research, and clinical research, with the objective of bridging the gaps between basic discovery and human disease.

Scholarship Deadline: November 4 2013

Discounted Abstract Deadline: November 4 2013

Abstract Deadline: December 4 2013

Discounted Registration Deadline: January 7 2014

We gratefully acknowledge additional support for this conference from:

March of Dimes Foundation Grant No. 4-FY14-469

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK101223-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, March 02 \| 4:00PM - 8:00PM Arrival and Registration Room: Pre Function
Sunday, March 02 \| 6:00PM - 8:00PM Light Meal - Provided by Granlibakken Room: Granhall
Monday, March 03 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Monday, March 03 \| 8:00AM - 9:00AM Keynote Address Room: Mountain/Lake Speaker 1 of 1 Kathryn V. Anderson, Memorial Sloan-Kettering Cancer Center, USA Regulation of Cilia Structure and Cilia Formation during Mouse Development
Monday, March 03 \| 9:00AM - 11:30AM Ciliary Structure, Formation and Resorption Room: Mountain/Lake Speaker 1 of 7 * Joel Rosenbaum, Yale University, USA
Monday, March 03 \| 9:00AM - 11:30AM Ciliary Structure, Formation and Resorption Room: Mountain/Lake Speaker 2 of 7 * Bradley K. Yoder, University of Alabama at Birmingham, USA
Monday, March 03 \| 9:00AM - 11:30AM Ciliary Structure, Formation and Resorption Room: Mountain/Lake Speaker 3 of 7 Wallace Marshall, University of California, San Francisco, USA The Flagellar Length Control System
Monday, March 03 \| 9:00AM - 11:30AM Ciliary Structure, Formation and Resorption Room: Mountain/Lake Speaker 4 of 7 Paul A. Lefebvre, University of Minnesota, USA The Role of Flagellar and Cytoplasmic Protein Kinases in the Control of Flagellar Length in Chlamydomonas
Monday, March 03 \| 9:00AM - 11:30AM Ciliary Structure, Formation and Resorption Room: Mountain/Lake Speaker 5 of 7 Cheryl L. Walker, Baylor College of Medicine, USA Targeting of Aurora Kinase A (AURKA) by the von Hippel-Lindau (VHL) Tumor Suppressor in Maintenance of the Primary Cilia
Monday, March 03 \| 9:00AM - 11:30AM Ciliary Structure, Formation and Resorption Room: Mountain/Lake Speaker 6 of 7 Christine Insinna Kettenhofen, NCI-Frederick National Laboratory, USA Short Talk: EHD and Rab Proteins Coordinate the Initiation of Ciliary Membrane Assembly
Monday, March 03 \| 9:00AM - 11:30AM Ciliary Structure, Formation and Resorption Room: Mountain/Lake Speaker 7 of 7 Mustafa k. Khokha, Yale University, USA Short Talk: The Heterotaxy Gene, GALNT11, Glycosylates Notch to Orchestrate Cilia Type and Laterality
Monday, March 03 \| 9:40AM - 10:00AM Coffee Break Room: Pre Function
Monday, March 03 \| 11:30AM - 1:00PM Poster Setup Room: Bay
Monday, March 03 \| 11:30AM - 5:00PM On Own for Lunch and Recreation
Monday, March 03 \| 1:00PM - 10:00PM Poster Viewing Room: Bay
Monday, March 03 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Monday, March 03 \| 5:00PM - 6:45PM Left-Right Patterning and Hedgehog Signaling Room: Mountain/Lake Speaker 1 of 5 * Gregory J. Pazour, University of Massachusetts Medical School, USA
Monday, March 03 \| 5:00PM - 6:45PM Left-Right Patterning and Hedgehog Signaling Room: Mountain/Lake Speaker 2 of 5 * Michael J. Caplan, Yale University, USA
Monday, March 03 \| 5:00PM - 6:45PM Left-Right Patterning and Hedgehog Signaling Room: Mountain/Lake Speaker 3 of 5 Bradley K. Yoder, University of Alabama at Birmingham, USA A Role for the Mammalian DRC Protein Gas8 in Left-Right Asymmetry and Cilia Motility
Monday, March 03 \| 5:00PM - 6:45PM Left-Right Patterning and Hedgehog Signaling Room: Mountain/Lake Speaker 4 of 5 Yingzi Yang, Harvard School of Dental Medicine, USA Planar Cell Polarity of Node Cells and Symmetry Breaking
Monday, March 03 \| 5:00PM - 6:45PM Left-Right Patterning and Hedgehog Signaling Room: Mountain/Lake Speaker 5 of 5 Bomi Jung, Institute of Diabetes and Regeneration, Germany Short Talk: Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation
Monday, March 03 \| 6:45PM - 7:45PM Dinner Room: Granhall
Monday, March 03 \| 7:30PM - 10:00PM Poster Session 1 Room: Bay
Monday, March 03 \| 8:00PM - 9:00PM Social Hour Room: Bay
Tuesday, March 04 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Tuesday, March 04 \| 8:00AM - 11:15AM Vesicle Transport and Trafficking Room: Mountain/Lake Speaker 1 of 8 * Jean Bennett, University of Pennsylvania, USA
Tuesday, March 04 \| 8:00AM - 11:15AM Vesicle Transport and Trafficking Room: Mountain/Lake Speaker 2 of 8 * Michel R. Leroux, Simon Fraser University, Canada
Tuesday, March 04 \| 8:00AM - 11:15AM Vesicle Transport and Trafficking Room: Mountain/Lake Speaker 3 of 8 Peter K. Jackson, Stanford University, USA Linking Cilia to Insulin Signaling in Preadipocytes
Tuesday, March 04 \| 8:00AM - 11:15AM Vesicle Transport and Trafficking Room: Mountain/Lake Speaker 4 of 8 Oliver Blacque, University College Dublin, Ireland New Transport Regulators at Cilia Base
Tuesday, March 04 \| 8:00AM - 11:15AM Vesicle Transport and Trafficking Room: Mountain/Lake Speaker 5 of 8 Gregory J. Pazour, University of Massachusetts Medical School, USA IFT25 and IFT27 Are Required for Maintenance of the Ciliary Signaling Compartment
Tuesday, March 04 \| 8:00AM - 11:15AM Vesicle Transport and Trafficking Room: Mountain/Lake Speaker 6 of 8 Markus Delling, University of California, San Francisco, USA The Primary Cilium is a Specialized Calcium Signaling Organelle
Tuesday, March 04 \| 8:00AM - 11:15AM Vesicle Transport and Trafficking Room: Mountain/Lake Speaker 7 of 8 Ellen J. Ezratty, Rockefeller University, USA Short Talk: An Emerging Role for Arl/Arf Family GTPases in Regulation of Cilia Function during Notch Signaling and Epidermal Differentiation
Tuesday, March 04 \| 8:00AM - 11:15AM Vesicle Transport and Trafficking Room: Mountain/Lake Speaker 8 of 8 John A. Martignetti, Mount Sinai School of Medicine, USA Short Talk: Inactivation of the Ciliary Protein CEP19 Results in a Novel Morbid Obesity Syndrome in Humans and Mice
Tuesday, March 04 \| 9:20AM - 9:40AM Coffee Break Room: Pre Function
Tuesday, March 04 \| 11:15AM - 1:00PM Poster Setup Room: Bay
Tuesday, March 04 \| 11:15AM - 5:00PM On Own for Lunch and Recreation
Tuesday, March 04 \| 1:00PM - 10:00PM Poster Viewing Room: Bay
Tuesday, March 04 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Tuesday, March 04 \| 5:00PM - 7:00PM Therapeutic Advances in Treating Ciliopathies Room: Mountain/Lake Speaker 1 of 5 * Elizabeth Petri Henske, Brigham and Women's Hospital, USA
Tuesday, March 04 \| 5:00PM - 7:00PM Therapeutic Advances in Treating Ciliopathies Room: Mountain/Lake Speaker 2 of 5 Jean Bennett, University of Pennsylvania, USA Ciliopathies Causing Blindness as Gene Therapy Targets: Progress and Prospects
Tuesday, March 04 \| 5:00PM - 7:00PM Therapeutic Advances in Treating Ciliopathies Room: Mountain/Lake Speaker 3 of 5 Ana Maria Cuervo, Albert Einstein College of Medicine, USA The Dual Interplay between Ciliogenesis and Autophagy
Tuesday, March 04 \| 5:00PM - 7:00PM Therapeutic Advances in Treating Ciliopathies Room: Mountain/Lake Speaker 4 of 5 Frederic J. de Sauvage, Genentech, Inc., USA Innate and Acquired Resistance to Hedgehog Pathways Inhibitors
Tuesday, March 04 \| 5:00PM - 7:00PM Therapeutic Advances in Treating Ciliopathies Room: Mountain/Lake Speaker 5 of 5 Ching-Hwa Sung, Cornell University, USA Short Talk: Light Regulates the Ciliary Protein Transport and Outer Segment Disc Renewal of Mammalian Photoreceptors
Tuesday, March 04 \| 7:00PM - 8:00PM Dinner Room: Granhall
Tuesday, March 04 \| 7:30PM - 10:00PM Poster Session 2 Room: Bay
Tuesday, March 04 \| 8:00PM - 9:00PM Social Hour Room: Bay
Wednesday, March 05 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Wednesday, March 05 \| 8:00AM - 11:15AM Cilia, Proliferation and Cancer Room: Mountain/Lake Speaker 1 of 7 * Cheryl L. Walker, Baylor College of Medicine, USA
Wednesday, March 05 \| 8:00AM - 11:15AM Cilia, Proliferation and Cancer Room: Mountain/Lake Speaker 2 of 7 Elizabeth Petri Henske, Brigham and Women's Hospital, USA Cilia and the Pathogenesis of Tuberous Sclerosis Complex
Wednesday, March 05 \| 8:00AM - 11:15AM Cilia, Proliferation and Cancer Room: Mountain/Lake Speaker 3 of 7 Jeremy F. Reiter, University of California, San Francisco, USA Do Cilia Participate in Common Diseases?
Wednesday, March 05 \| 8:00AM - 11:15AM Cilia, Proliferation and Cancer Room: Mountain/Lake Speaker 4 of 7 Brian D. Dynlacht, New York University School of Medicine, USA Regulation of the Centrosome-Cilium Cycle
Wednesday, March 05 \| 8:00AM - 11:15AM Cilia, Proliferation and Cancer Room: Mountain/Lake Speaker 5 of 7 Erica A. Golemis, Fox Chase Cancer Center, USA Probing the Relationship between Cilia and Cystogenesis in Models of ADPKD
Wednesday, March 05 \| 8:00AM - 11:15AM Cilia, Proliferation and Cancer Room: Mountain/Lake Speaker 6 of 7 Mattias Alenius, Linkoping University, Sweden Short Talk: Cilia-Mediated Hedgehog Signaling in Drosophila
Wednesday, March 05 \| 8:00AM - 11:15AM Cilia, Proliferation and Cancer Room: Mountain/Lake Speaker 7 of 7 Daniel B. Constam, École Polytechnique Fédérale de Lausanne, Switzerland Short Talk: Regulation of Bicc1-Mediated mRNA Silencing by Calcium
Wednesday, March 05 \| 9:20AM - 9:40AM Coffee Break Room: Pre Function
Wednesday, March 05 \| 11:15AM - 1:00PM Poster Setup Room: Bay
Wednesday, March 05 \| 11:15AM - 5:00PM On Own for Lunch and Recreation
Wednesday, March 05 \| 1:00PM - 10:00PM Poster Viewing Room: Bay
Wednesday, March 05 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Wednesday, March 05 \| 5:00PM - 7:15PM Cystic Disease Room: Mountain/Lake Speaker 1 of 7 * Erica A. Golemis, Fox Chase Cancer Center, USA
Wednesday, March 05 \| 5:00PM - 7:15PM Cystic Disease Room: Mountain/Lake Speaker 2 of 7 * Jeremy F. Reiter, University of California, San Francisco, USA
Wednesday, March 05 \| 5:00PM - 7:15PM Cystic Disease Room: Mountain/Lake Speaker 3 of 7 Friedhelm Hildebrandt, Howard Hughes Medical Institute and Boston Children’s Hospital, USA DNA Damage Response Signaling in Ciliopathies
Wednesday, March 05 \| 5:00PM - 7:15PM Cystic Disease Room: Mountain/Lake Speaker 4 of 7 Michael J. Caplan, Yale University, USA The Polycystins and Ciliary Sensing
Wednesday, March 05 \| 5:00PM - 7:15PM Cystic Disease Room: Mountain/Lake Speaker 5 of 7 Kimberly M. McDermott, Kimberly McDermott Coaching, USA Investigating the Role of Primary Cilia in Hedgehog Pathway Drug Resistance
Wednesday, March 05 \| 5:00PM - 7:15PM Cystic Disease Room: Mountain/Lake Speaker 6 of 7 Sandra Hakim, Monash University, Australia Short Talk: Inpp5e Regulates Cilia and mTOR Signaling in Renal Epithelial Cells to Suppress Polycystic Kidney Disease
Wednesday, March 05 \| 5:00PM - 7:15PM Cystic Disease Room: Mountain/Lake Speaker 7 of 7 Rannar Airik, Boston Children’s Hospital, USA Short Talk: Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response signaling
Wednesday, March 05 \| 7:15PM - 8:15PM Dinner Room: Granhall
Wednesday, March 05 \| 7:30PM - 10:00PM Poster Session 3 Room: Bay
Wednesday, March 05 \| 8:00PM - 9:00PM Social Hour Room: Bay
Thursday, March 06 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Thursday, March 06 \| 8:00AM - 11:00AM Signaling to and from the Cilium Room: Mountain/Lake Speaker 1 of 7 * Kathryn V. Anderson, Memorial Sloan-Kettering Cancer Center, USA
Thursday, March 06 \| 8:00AM - 11:00AM Signaling to and from the Cilium Room: Mountain/Lake Speaker 2 of 7 Adrian Salic, Harvard Medical School, USA Hedgehogs and Sterols
Thursday, March 06 \| 8:00AM - 11:00AM Signaling to and from the Cilium Room: Mountain/Lake Speaker 3 of 7 Philip A. Beachy, HHMI/Stanford University, USA Hedgehog Signaling, Cilia and Cancer
Thursday, March 06 \| 8:00AM - 11:00AM Signaling to and from the Cilium Room: Mountain/Lake Speaker 4 of 7 Tao P. Zhong, East China Normal University, China Short Talk; Prostaglandin Signaling Regulates Ciliogenesis through Modulating Intraflagellar Transport
Thursday, March 06 \| 8:00AM - 11:00AM Signaling to and from the Cilium Room: Mountain/Lake Speaker 5 of 7 Elle C. Roberson, University of California, San Francisco, USA Short Talk: Tmem231 is a Ciliopathy Protein Required for Ciliary Membrane Protein Composition
Thursday, March 06 \| 8:00AM - 11:00AM Signaling to and from the Cilium Room: Mountain/Lake Speaker 6 of 7 Ruhee Dere, Baylor College of Medicine, USA Short Talk: Aurora Kinase A (AURKA) Inhibition Rescues Renal Cystogenesis, Independent of mTORC1 Activation, in a Ciliopathy Model of Tsc2
Thursday, March 06 \| 8:00AM - 11:00AM Signaling to and from the Cilium Room: Mountain/Lake Speaker 7 of 7 * Cosima T. Baldari, University of Siena, Italy Short Talk: The Atypical Rab GTPase, Rab29, Is a Common Regulator of Immune Synapse Assembly and Ciliogenesis
Thursday, March 06 \| 9:20AM - 9:40AM Coffee Break Room: Pre Function
Thursday, March 06 \| 11:00AM - 5:00PM On Own for Lunch and Recreation
Thursday, March 06 \| 4:30PM - 5:00PM Coffee Available Room: Pre Function
Thursday, March 06 \| 5:00PM - 7:00PM Protein Localization to Cilia Room: Mountain/Lake Speaker 1 of 5 * Kimberly M. McDermott, Kimberly McDermott Coaching, USA
Thursday, March 06 \| 5:00PM - 7:00PM Protein Localization to Cilia Room: Mountain/Lake Speaker 2 of 5 Michel R. Leroux, Simon Fraser University, Canada Formation and Function of the Transition Zone, a Ciliary Gate
Thursday, March 06 \| 5:00PM - 7:00PM Protein Localization to Cilia Room: Mountain/Lake Speaker 3 of 5 * Kristen Verhey, University of Michigan, USA Regulating Entry into the Ciliary Compartment
Thursday, March 06 \| 5:00PM - 7:00PM Protein Localization to Cilia Room: Mountain/Lake Speaker 4 of 5 Stefan Somlo, Yale School of Medicine, USA Polycystic Kidney and Liver Diseases: From Gene Discovery to Mechanism
Thursday, March 06 \| 5:00PM - 7:00PM Protein Localization to Cilia Room: Mountain/Lake Speaker 5 of 5 Ahmet Yildiz, University of California, Berkeley, USA Short Talk: Direct Observation of IFT Turnover at the Flagellar Tip and Base using the Photobleaching Gate Assay
Thursday, March 06 \| 7:00PM - 7:15PM Closing Remarks Room: Mountain/Lake Speaker 1 of 3 Elizabeth Petri Henske, Brigham and Women's Hospital, USA
Thursday, March 06 \| 7:00PM - 7:15PM Closing Remarks Room: Mountain/Lake Speaker 2 of 3 Jeremy F. Reiter, University of California, San Francisco, USA
Thursday, March 06 \| 7:00PM - 7:15PM Closing Remarks Room: Mountain/Lake Speaker 3 of 3 Joel Rosenbaum, Yale University, USA
Thursday, March 06 \| 7:15PM - 8:15PM Dinner Room: Granhall
Thursday, March 06 \| 7:15PM - 8:15PM Social Hour Room: Granhall
Thursday, March 06 \| 8:00PM - 11:00PM Entertainment Room: Granhall
Thursday, March 06 \| 8:15PM - 11:00PM Cash Bar Room: Granhall
Friday, March 07 \| 10:25AM - 10:25AM Departure *Session Chair.