Web Desc
Mobile Genetic Elements and Genome Evolution
Organizer(s): Nancy L. Craig, Henry L. Levin and Cedric Feschotte
Date: March 09 - 14, 2014
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Supported by the Directors' Fund
Summary of Meeting:
Transposable elements are powerful engines of evolution. They constitute the majority of genomic DNA in many eukaryotes, and they dramatically shape genetic content by causing mutations, rearrangements and sequence duplications. Of increasing significance is the link of these transposon-mediated mutations to disease. Sequencing of human populations demonstrates that active transposons are substantially more prevalent than previously appreciated. The aims of this conference are to: 1) Apply recent innovations in high-throughput sequencing and genome analysis to the study of transposon biology and genome evolution; 2) Discuss the discovery of cellular systems that inhibit transposon activity as examples of the evolutionary arms race that exists between mobile DNA and their hosts; and 3) Describe active transposition during neurogenesis and in tumor cells and raise fundamental questions about the role of mobile DNA in brain development and cancer. The symposium is designed to foster ties between leaders in the field of transposon biology and the pioneers of genome analysis. Discussions of transposon activity and genome evolution will focus on mechanistic models. Methods applied to these problems include molecular structures, biochemistry, expression studies and bioinformatic analyses. The transposons and hosts represented in this meeting include diverse examples from eubacteria, archaea, protists, plants and mammals.
Scholarship Deadline: November 6 2013
Discounted Abstract Deadline: November 6 2013
Abstract Deadline: December 9 2013
Discounted Registration Deadline: January 8 2014
We gratefully acknowledge additional support for this conference from:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)March of Dimes Foundation Grant No. 4-FY14-469
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Illumina, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
PLOS Genetics
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, March 09 | 4:00PM - 8:00PM
Arrival and Registration
Room: Promenade


Monday, March 10 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Monday, March 10 | 8:00AM - 9:40AM
Keynote Session
Room: Mesa A-B

Speaker 1 of 2
Allan C. Spradling, HHMI/Carnegie Institute, USA
Transposon Regulation and Genome Evolution

Monday, March 10 | 8:00AM - 9:40AM
Keynote Session
Room: Mesa A-B

Speaker 2 of 2
Haig H. Kazazian, Johns Hopkins University School of Medicine, USA
Biology of Human Retrotransposons: A Potential Role for Retrotransposition in Tumorigenesis?

Monday, March 10 | 9:40AM - 10:00AM
Coffee Break
Room: Promenade


Monday, March 10 | 10:00AM - 11:30AM
Transposon Applications and Human Health
Room: Mesa A-B

Speaker 1 of 4
Gerald G. Schumann, Paul-Ehrlich-Institute, Germany
Short Talk: Reprogramming Triggers Mutagenic Endogenous L1, Alu and SVA Retrotransposition in Human Induced Pluripotent Stem Cells

Monday, March 10 | 10:00AM - 11:30AM
Transposon Applications and Human Health
Room: Mesa A-B

Speaker 2 of 4
Frederic D. Bushman, University of Pennsylvania, USA
Viral Metagenomes

Monday, March 10 | 10:00AM - 11:30AM
Transposon Applications and Human Health
Room: Mesa A-B

Speaker 3 of 4
Shawn M. Burgess, NHGRI, National Institutes of Health, USA
Short Talk: MLV Integration Site Selection Is Driven by Strong Enhancers and Active Promoters: Implications for Genome Evolution and Gene Therapy

Monday, March 10 | 10:00AM - 11:30AM
Transposon Applications and Human Health
Room: Mesa A-B

Speaker 4 of 4
* Kevin L. Gunderson, Illumina, Inc., USA
In vitro Transposition Assays for Next Generation Sequencing Library Preparation

Monday, March 10 | 11:30AM - 1:00PM
Poster Setup
Room: Mesa C


Monday, March 10 | 11:30AM - 5:00PM
On Own for Lunch and Recreation


Monday, March 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Monday, March 10 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Monday, March 10 | 5:00PM - 7:00PM
A Transposon-Eye View of Primate Evolution
Room: Mesa A-B

Speaker 1 of 5
Mark A. Batzer, Louisiana State University, USA
Mobile Elements and Genomic Variation

Monday, March 10 | 5:00PM - 7:00PM
A Transposon-Eye View of Primate Evolution
Room: Mesa A-B

Speaker 2 of 5
Geoffrey J. Faulkner, Queensland Brain Institute, Australia
L1 Mobilization in the Mammalian Hippocampus

Monday, March 10 | 5:00PM - 7:00PM
A Transposon-Eye View of Primate Evolution
Room: Mesa A-B

Speaker 3 of 5
David B. Greenberg, University of California, Santa Cruz, USA
Short Talk: ZNF91 and ZNF93 Evolved to Restrict SVA and L1 Mobile Elements in Ape Genomes

Monday, March 10 | 5:00PM - 7:00PM
A Transposon-Eye View of Primate Evolution
Room: Mesa A-B

Speaker 4 of 5
Pam Cook, NIDDK, National Institutes of Health, USA
Short Talk: Phosphorylation of ORF1p on Conserved MAPK Target and Docking Motifs Regulates L1 Retrotransposition

Monday, March 10 | 5:00PM - 7:00PM
A Transposon-Eye View of Primate Evolution
Room: Mesa A-B

Speaker 5 of 5
* John V. Moran, University of Michigan Medical School, USA
The L1 Poly (A) Tail is Required for Efficient Retrotransposition

Monday, March 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Monday, March 10 | 7:30PM - 10:00PM
Poster Session 1
Room: Mesa C


Tuesday, March 11 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Tuesday, March 11 | 7:30AM - 8:00AM
Poster Setup
Room: Mesa C


Tuesday, March 11 | 8:00AM - 7:00PM
Poster Viewing
Room: Mesa C


Tuesday, March 11 | 8:00AM - 11:00AM
Mechanisms of Genome Evolution I
Room: Mesa A-B

Speaker 1 of 6
Marlene Belfort, University of Albany, SUNY, USA
How Intron Retro-Elements Shape Genomes in Bacteria and Yeast

Tuesday, March 11 | 8:00AM - 11:00AM
Mechanisms of Genome Evolution I
Room: Mesa A-B

Speaker 2 of 6
Lynne E. Maquat, University of Rochester Medical Center, USA
Control of Gene Expression via SINE-Containing lncRNAs and mRNAs

Tuesday, March 11 | 8:00AM - 11:00AM
Mechanisms of Genome Evolution I
Room: Mesa A-B

Speaker 3 of 6
Scott Waddell, University of Oxford, UK
Short Talk: Transposition Driven Genomic Heterogeneity in the Drosophila Brain

Tuesday, March 11 | 8:00AM - 11:00AM
Mechanisms of Genome Evolution I
Room: Mesa A-B

Speaker 4 of 6
Kazufumi Mochizuki, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria
Two Types of Eliminated Sequences Express Different Classes of siRNAs during Programmed DNA Elimination in Tetrahymena

Tuesday, March 11 | 8:00AM - 11:00AM
Mechanisms of Genome Evolution I
Room: Mesa A-B

Speaker 5 of 6
Guillaume Cornelis, Stanford University, USA
Short Talk: Syncytin Env Gene Capture: Taming of Endogenous Retroviruses Involved in Placenta Formation and Diversity in Mammals

Tuesday, March 11 | 8:00AM - 11:00AM
Mechanisms of Genome Evolution I
Room: Mesa A-B

Speaker 6 of 6
* Guillaume Bourque, McGill University, Canada
Transposable Elements: Innovation and Biochemical Noise in the Human Genome

Tuesday, March 11 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Tuesday, March 11 | 11:00AM - 12:00PM
Lunch
Room: Mesa C


Tuesday, March 11 | 12:00PM - 2:30PM
Poster Session 2
Room: Mesa C


Tuesday, March 11 | 2:30PM - 4:30PM
Workshop 1: Transposition Mechanisms and Regulation
Room: Mesa A-B

Speaker 1 of 7
Stuart F.J. Le Grice, NCI, National Institutes of Health, USA
Ty3 Reverse Transcriptase Complexed with an RNA/DNA Hybrid Shows Structural and Functional Asymmetry

Tuesday, March 11 | 2:30PM - 4:30PM
Workshop 1: Transposition Mechanisms and Regulation
Room: Mesa A-B

Speaker 2 of 7
Jake Z. Jacobs, Rutgers University, USA
Sap1 Replication Fork Barrier Activity Guides the Integration of LTR Retrotransposons in Fission Yeast

Tuesday, March 11 | 2:30PM - 4:30PM
Workshop 1: Transposition Mechanisms and Regulation
Room: Mesa A-B

Speaker 3 of 7
Orsolya Barabas, European Molecular Biology Laboratory, Germany
Crystal Structure of a Conjugative Transposon Integrase: Insights into Tyrosine Recombination without Homology

Tuesday, March 11 | 2:30PM - 4:30PM
Workshop 1: Transposition Mechanisms and Regulation
Room: Mesa A-B

Speaker 4 of 7
Bao Ton-Hoang, Laboratoire de Microbiologie et de Génétique Moléculaire, LMGM, France
Single Strand Transposases and Genome Dynamics

Tuesday, March 11 | 2:30PM - 4:30PM
Workshop 1: Transposition Mechanisms and Regulation
Room: Mesa A-B

Speaker 5 of 7
Antoine Molaro, Fred Hutchinson Cancer Research Center, USA
Multiple Waves of de novo Methylation during Mouse Germ Cell Development

Tuesday, March 11 | 2:30PM - 4:30PM
Workshop 1: Transposition Mechanisms and Regulation
Room: Mesa A-B

Speaker 6 of 7
Sergey G. Shpiz, Institute of Molecular Genetics, Russia
Transposon-Induced piRNA Cluster Formation

Tuesday, March 11 | 2:30PM - 4:30PM
Workshop 1: Transposition Mechanisms and Regulation
Room: Mesa A-B

Speaker 7 of 7
* R. Keith Slotkin, Ohio State University, USA
Transposable Element Small Interfering RNAs Regulate Genic mRNAs and Inhibit Host TE Silencing

Tuesday, March 11 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Tuesday, March 11 | 5:00PM - 7:00PM
Mechanisms of Genome Evolution II
Room: Mesa A-B

Speaker 1 of 5
David M. Kingsley, Stanford University, USA
Fishing for the Secrets of Vertebrate Evolution

Tuesday, March 11 | 5:00PM - 7:00PM
Mechanisms of Genome Evolution II
Room: Mesa A-B

Speaker 2 of 5
Daniel A. Barbash, Cornell University, USA
How Species Cope with Genomic Cancer

Tuesday, March 11 | 5:00PM - 7:00PM
Mechanisms of Genome Evolution II
Room: Mesa A-B

Speaker 3 of 5
Anne-Marie Dion-Côté, University Laval, Canada
Short Talk: Fast-Forward Speciation: Investigating the Role of Transposable Elements in Reproductive Isolation

Tuesday, March 11 | 5:00PM - 7:00PM
Mechanisms of Genome Evolution II
Room: Mesa A-B

Speaker 4 of 5
David R. Kelley, Harvard University, USA
Short Talk: RNA Binding Proteins Interact Specifically with Transposable Element Sequence in Human Genes

Tuesday, March 11 | 5:00PM - 7:00PM
Mechanisms of Genome Evolution II
Room: Mesa A-B

Speaker 5 of 5
* Cedric Feschotte, Cornell University, USA
Flexible Genomes for Better Flyers: Evolution of the Bat Genome

Tuesday, March 11 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, March 12 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Wednesday, March 12 | 8:00AM - 11:00AM
The Contribution of Host Factors to DNA Mobility
Room: Mesa A-B

Speaker 1 of 7
Suzanne B. Sandmeyer, University of California, Irvine, USA
Ty3 Promoters: Making Sense from the Change

Wednesday, March 12 | 8:00AM - 11:00AM
The Contribution of Host Factors to DNA Mobility
Room: Mesa A-B

Speaker 2 of 7
Jef D. Boeke, New York University Langone Medical Center, USA
Affinity Proteomics Reveals Human Host Factors for L1 Retrotransposition

Wednesday, March 12 | 8:00AM - 11:00AM
The Contribution of Host Factors to DNA Mobility
Room: Mesa A-B

Speaker 3 of 7
Axel V. Horn, Tulane University, USA
Short Talk: The ESCRT Cargo-Sorting Pathway Is Involved in LINE Retrotransposition

Wednesday, March 12 | 8:00AM - 11:00AM
The Contribution of Host Factors to DNA Mobility
Room: Mesa A-B

Speaker 4 of 7
Alan N. Engelman, Dana-Farber Cancer Institute, USA
Host Factors and Multimodal HIV-1 Integrase Inhibitors

Wednesday, March 12 | 8:00AM - 11:00AM
The Contribution of Host Factors to DNA Mobility
Room: Mesa A-B

Speaker 5 of 7
Pascale Lesage, Institut Universitaire d'Hématologie, France
Short Talk: An Essential Role of Pol III Subunit AC40 in Ty1 Integration Targeting

Wednesday, March 12 | 8:00AM - 11:00AM
The Contribution of Host Factors to DNA Mobility
Room: Mesa A-B

Speaker 6 of 7
Mireille Bétermier, CNRS UPR 3404, France
Short Talk: Ku-Mediated Coupling of DNA Cleavage and Repair during Programmed Genome Rearrangements in Paramecium

Wednesday, March 12 | 8:00AM - 11:00AM
The Contribution of Host Factors to DNA Mobility
Room: Mesa A-B

Speaker 7 of 7
* Nancy L. Craig, Johns Hopkins University School of Medicine, USA
Transposon Mechanism and Regulation

Wednesday, March 12 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Wednesday, March 12 | 11:00AM - 1:00PM
Poster Setup
Room: Mesa C


Wednesday, March 12 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Wednesday, March 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Wednesday, March 12 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Wednesday, March 12 | 5:00PM - 7:00PM
The Biological Impact of Mobile DNA, Friend or Foe I
Room: Mesa A-B

Speaker 1 of 5
Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Nuclear RNA Processing Network and Cryptic Introns Target RNAi to Silence Retrotransposons

Wednesday, March 12 | 5:00PM - 7:00PM
The Biological Impact of Mobile DNA, Friend or Foe I
Room: Mesa A-B

Speaker 2 of 5
Michelle S. Longworth, Cleveland Clinic Lerner Research Institute, USA
Short Talk: Condensin II Subunit dCAP-D3 Prevents Retrotransposon Destabilization in Drosophila Somatic Cells

Wednesday, March 12 | 5:00PM - 7:00PM
The Biological Impact of Mobile DNA, Friend or Foe I
Room: Mesa A-B

Speaker 3 of 5
Damon R. Lisch, University of California, Berkeley, USA
Causes and Consequences of MuDR Transposon Silencing in Maize

Wednesday, March 12 | 5:00PM - 7:00PM
The Biological Impact of Mobile DNA, Friend or Foe I
Room: Mesa A-B

Speaker 4 of 5
Axel Imhof, Ludwig Maximilians University of Munich, Germany
Short Talk: A Pair of Centromeric Proteins Mediates Reproductive Isolation in Drosophila Species

Wednesday, March 12 | 5:00PM - 7:00PM
The Biological Impact of Mobile DNA, Friend or Foe I
Room: Mesa A-B

Speaker 5 of 5
* Henry L. Levin, NIH, USA
The Biological Impact of Mobile DNA

Wednesday, March 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz


Wednesday, March 12 | 7:30PM - 10:00PM
Poster Session 3
Room: Mesa C


Thursday, March 13 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Thursday, March 13 | 8:00AM - 11:00AM
The Biological Impact of Mobile DNA, Friend or Foe II
Room: Mesa A-B

Speaker 1 of 6
William Theurkauf, University of Massachusetts Medical Center, USA
A Role for Germline Transposition in Adaptation to Genetic Stress

Thursday, March 13 | 8:00AM - 11:00AM
The Biological Impact of Mobile DNA, Friend or Foe II
Room: Mesa A-B

Speaker 2 of 6
Luciano A. Marraffini, Rockefeller University, USA
Tolerance during CRISPR-Cas Immunity: Domesticating the Virus

Thursday, March 13 | 8:00AM - 11:00AM
The Biological Impact of Mobile DNA, Friend or Foe II
Room: Mesa A-B

Speaker 3 of 6
Grace A. Wyngaard, James Madison University, USA
Short Talk: Billions of Basepairs of Recently Expanded, Repetitive Sequences Are Eliminated from the Somatic Genome during Copepod Development

Thursday, March 13 | 8:00AM - 11:00AM
The Biological Impact of Mobile DNA, Friend or Foe II
Room: Mesa A-B

Speaker 4 of 6
Todd S. Macfarlan, NICHD, National Institutes of Health, USA
Short Talk: KRAB-ZNF Proteins Function as Species-Specific Pro-Viral Silencers

Thursday, March 13 | 8:00AM - 11:00AM
The Biological Impact of Mobile DNA, Friend or Foe II
Room: Mesa A-B

Speaker 5 of 6
Vasavi Sundaram, Washington University in St. Louis, USA
Short Talk: Characterization of Transposable Elements’ Contribution to the Innovation of Gene Regulatory Networks in Human and Mouse

Thursday, March 13 | 8:00AM - 11:00AM
The Biological Impact of Mobile DNA, Friend or Foe II
Room: Mesa A-B

Speaker 6 of 6
* Harmit S. Malik, Fred Hutchinson Cancer Research Center, USA
Genetic Conflicts between Host and Viral Genomes

Thursday, March 13 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Thursday, March 13 | 11:00AM - 2:30PM
On Own for Lunch and Recreation


Thursday, March 13 | 2:30PM - 4:30PM
Workshop 2: Genetic Variation and Evolution
Room: Mesa A-B

Speaker 1 of 7
Peter W. Atkinson, University of California, Riverside, USA
The Muta1 Transposon from the Mosquito Aedes aegypti Is Active in its Host Insect and a Range of Organisms

Thursday, March 13 | 2:30PM - 4:30PM
Workshop 2: Genetic Variation and Evolution
Room: Mesa A-B

Speaker 2 of 7
Csaba Miskey, Paul Ehrlich Institut, Germany
Search for the Primate-Specific Functions of SETMAR, a Domesticated, Transposase-Derived Protein in Apes and Humans

Thursday, March 13 | 2:30PM - 4:30PM
Workshop 2: Genetic Variation and Evolution
Room: Mesa A-B

Speaker 3 of 7
Keizo Tomonaga, Kyoto University, Japan
Endogenous Bornavirus-Like Elements: Cellular Co-Option and Impact on Genome Evolution

Thursday, March 13 | 2:30PM - 4:30PM
Workshop 2: Genetic Variation and Evolution
Room: Mesa A-B

Speaker 4 of 7
Josefa González, Institut de Biologia Evolutiva, CSIC-Universitat Pompeu Fabra, Spain
A Transposable Element Insertion Confers Xenobiotic Resistance in Drosophila

Thursday, March 13 | 2:30PM - 4:30PM
Workshop 2: Genetic Variation and Evolution
Room: Mesa A-B

Speaker 5 of 7
Inigo Narvaiza, Takeda, USA
Differential L1 Regulation in Induced Pluripotent Stem Cells between Humans and Great Apes

Thursday, March 13 | 2:30PM - 4:30PM
Workshop 2: Genetic Variation and Evolution
Room: Mesa A-B

Speaker 6 of 7
Liana Fasching, Wallenberg Neuroscience Center, Lund University, Sweden
Transcriptional Co-Repressor TRIM28 controls Endogenous Retroviruses in Neural Progenitor Cells

Thursday, March 13 | 2:30PM - 4:30PM
Workshop 2: Genetic Variation and Evolution
Room: Mesa A-B

Speaker 7 of 7
* Josh Dubnau, Stony Brook University, USA
The Transposon Storm Hypothesis of Neurodegeneration

Thursday, March 13 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Thursday, March 13 | 5:00PM - 7:00PM
The Interface between Mobile DNA, DNA Replication and DNA Re
pair/The Molecular Face of Transposition

Room: Mesa A-B

Speaker 1 of 4
Rasika M. Harshey, University of Texas at Austin, USA
Repair of Mu DNA Insertions

Thursday, March 13 | 5:00PM - 7:00PM
The Interface between Mobile DNA, DNA Replication and DNA Re
pair/The Molecular Face of Transposition

Room: Mesa A-B

Speaker 2 of 4
Fred Dyda, NIDDK, National Institutes of Health, USA
The Architecture of Hermes, a hAT Family DNA Transposase

Thursday, March 13 | 5:00PM - 7:00PM
The Interface between Mobile DNA, DNA Replication and DNA Re
pair/The Molecular Face of Transposition

Room: Mesa A-B

Speaker 3 of 4
Phoebe A. Rice, University of Chicago, USA
Why Are Two Recombinases Better than One: The Large S Recombinases of MRSA

Thursday, March 13 | 5:00PM - 7:00PM
The Interface between Mobile DNA, DNA Replication and DNA Re
pair/The Molecular Face of Transposition

Room: Mesa A-B

Speaker 4 of 4
* Joseph E. Peters, Cornell University, USA
Heterologous Expression Reveals a Mechanism for Transposon Tn7 Host Specificity through Adaptation to Replication Processivity Factor

Thursday, March 13 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Promenade/Mesa Ballroom


Thursday, March 13 | 8:00PM - 11:00PM
Entertainment
Room: Mesa Ballroom


Thursday, March 13 | 9:00PM - 11:00PM
Cash Bar
Room: Mesa Ballroom


Friday, March 14 | 10:25AM - 10:25AM
Departure


*Session Chair.