Web Desc
Chromatin Mechanisms and Cell Physiology
Organizer(s): Thomas Jenuwein and Shelley L. Berger
Date: March 23 - 28, 2014
Location: Oberstdorf Haus, Oberstdorf, Germany
Sponsored by Bayer HealthCare Pharmaceuticals, Constellation Pharmaceuticals and the German Ministry of Education and Research (BMBF).
Summary of Meeting:
Chromatin is the physiological form of DNA in eukaryotic cells and thus serves as a template for many basic DNA related processes (e.g., transcription, repair, replication, recombination). Dynamic changes in chromatin structure are essential for the organization and utilization of our genetic information and are mediated by epigenetic mechanisms such as histone/DNA modifications, non-coding RNAs and chromatin remodeling. The establishment, maintenance and plasticity of distinct chromatin states are crucial for embryonic development, cell differentiation and cell type identity, as well as allowing response to environmental cues such as hormones, stress or nutrients. Chromatin dysfunction also significantly contributes to cell transformation and perturbed development. This Keystone meeting will highlight novel findings in mechanisms of dynamic chromatin regulation and their translation into cellular physiology. In particular, we will focus on four fundamental chromatin processes (RNA regulation, transcription and remodeling, DNA damage and repair, DNA replication) in conjunction with normal and perturbed cellular states (cell fate, signal response, cell transformation, epigenetic inheritance). Sessions feature basic and applied research in model systems ranging from plants to fungi to mammals. This open and inclusive program should generate intense discussions, interesting synergies and a strong bridge connecting basic chromatin research with cellular physiology. This link is beneficial to further explore the dynamic (mis)-regulation of chromatin-based processes in medically relevant research fields investigating complex human disorders or stem cell therapy.
Scholarship Deadline: November 20 2013
Discounted Abstract Deadline: November 20 2013
Abstract Deadline: December 19 2013
Discounted Registration Deadline: January 22 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer HealthCare PharmaceuticalsConstellation PharmaceuticalsGerman Ministry of Education and Research (BMBF)
We gratefully acknowledge additional support for this conference from:
Abcam plcBethyl Laboratories, Inc.Cell Signaling Technology, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
EMBO (European Molecular Biology Organization)
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 23 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Sunday, March 23 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer


Monday, March 24 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Monday, March 24 | 8:30AM - 11:45AM
Chromatin Modifications
Room: Nebelhorn

Speaker 1 of 5
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
TET Proteins and 5-Methylcytosine Oxidation

Monday, March 24 | 8:30AM - 11:45AM
Chromatin Modifications
Room: Nebelhorn

Speaker 2 of 5
* Ali Shilatifard, Northwestern University, USA
Enhancer Malfunction in Cancer

Monday, March 24 | 8:30AM - 11:45AM
Chromatin Modifications
Room: Nebelhorn

Speaker 3 of 5
Henk G. Stunnenberg, Radboud University, Netherlands
Epigenomics: Functional Indexing Genomes in Health and Disease

Monday, March 24 | 8:30AM - 11:45AM
Chromatin Modifications
Room: Nebelhorn

Speaker 4 of 5
Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany
Epigenetic Regulation of the X Chromosome

Monday, March 24 | 8:30AM - 11:45AM
Chromatin Modifications
Room: Nebelhorn

Speaker 5 of 5
Jörn Walter, Saarland University, Germany
DNA Methylation and the Shaping of the Epigenome

Monday, March 24 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Monday, March 24 | 11:45AM - 1:00PM
Poster Setup
Room: Nebelhorn


Monday, March 24 | 11:45AM - 2:30PM
On Own for Lunch and Recreation


Monday, March 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Nebelhorn


Monday, March 24 | 2:30PM - 4:30PM
Panel: Epigenetic Inheritance
Room: Nebelhorn

Speaker 1 of 2
* Shelley L. Berger, University of Pennsylvania, USA

Monday, March 24 | 2:30PM - 4:30PM
Panel: Epigenetic Inheritance
Room: Nebelhorn

Speaker 2 of 2
Bradley R. Cairns, HHMI/University of Utah, USA

Monday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, March 24 | 5:00PM - 7:00PM
Cell Fate
Room: Nebelhorn

Speaker 1 of 5
* Geneviève Almouzni, Centre National de la Recherche Scientifique, France

Monday, March 24 | 5:00PM - 7:00PM
Cell Fate
Room: Nebelhorn

Speaker 2 of 5
Alexander Meissner, Max Planck Institute for Molecular Genetics, Germany
DNA Methylation Dynamics in Stem Cells and Development

Monday, March 24 | 5:00PM - 7:00PM
Cell Fate
Room: Nebelhorn

Speaker 3 of 5
Azim Surani, University of Cambridge, UK
Germline – Specification and Epigenetic Programming

Monday, March 24 | 5:00PM - 7:00PM
Cell Fate
Room: Nebelhorn

Speaker 4 of 5
Amanda G. Fisher, Imperial College London, UK
Human X Chromosome Reactivation by Cell Fusion Reprogramming

Monday, March 24 | 5:00PM - 7:00PM
Cell Fate
Room: Nebelhorn

Speaker 5 of 5
Maria-Elena Torres-Padilla, Helmholtz Centre Munich, Germany
Short Talk: Novel Chromatin Pathways to Induce Totipotency

Monday, March 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breitachklamm


Monday, March 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Nebelhorn


Tuesday, March 25 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Tuesday, March 25 | 8:30AM - 11:45AM
Transcription and Chromatin Remodeling
Room: Nebelhorn

Speaker 1 of 7
* Amanda G. Fisher, Imperial College London, UK

Tuesday, March 25 | 8:30AM - 11:45AM
Transcription and Chromatin Remodeling
Room: Nebelhorn

Speaker 2 of 7
Bradley R. Cairns, HHMI/University of Utah, USA
The Regulation of Chromatin Remodeling ATPases

Tuesday, March 25 | 8:30AM - 11:45AM
Transcription and Chromatin Remodeling
Room: Nebelhorn

Speaker 3 of 7
Huck-Hui Ng, Genome Institute of Singapore, Singapore
Transcriptional Regulatory Networks in Embryonic Stem Cells

Tuesday, March 25 | 8:30AM - 11:45AM
Transcription and Chromatin Remodeling
Room: Nebelhorn

Speaker 4 of 7
Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Nucleosome Dynamics and Histone Variants

Tuesday, March 25 | 8:30AM - 11:45AM
Transcription and Chromatin Remodeling
Room: Nebelhorn

Speaker 5 of 7
Jerry L. Workman, Stowers Institute for Medical Research, USA
Histone Modification and Exchange during Gene Transcription: Signals and Mechanisms

Tuesday, March 25 | 8:30AM - 11:45AM
Transcription and Chromatin Remodeling
Room: Nebelhorn

Speaker 6 of 7
Armelle Corpet, University Hospital Zürich, Switzerland
Short Talk: Daxx-Dependent Targeting of New H3.3 to PML Bodies in Proliferating and Senescent Cells

Tuesday, March 25 | 8:30AM - 11:45AM
Transcription and Chromatin Remodeling
Room: Nebelhorn

Speaker 7 of 7
Julie Ahringer, University of Cambridge, UK
Short Talk: Extreme HOT Regions Are CpG Dense Promoters in C. elegans and Humans

Tuesday, March 25 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Tuesday, March 25 | 11:45AM - 1:00PM
Poster Setup
Room: Nebelhorn


Tuesday, March 25 | 11:45AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Nebelhorn


Tuesday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, March 25 | 5:00PM - 7:00PM
Signal Response
Room: Nebelhorn

Speaker 1 of 5
* Nicholas J. Proudfoot, University of Oxford, UK

Tuesday, March 25 | 5:00PM - 7:00PM
Signal Response
Room: Nebelhorn

Speaker 2 of 5
Paolo Sassone-Corsi, University of California, Irvine, USA
Mammalian Circadian Clock and Metabolism: The Epigenetic Link

Tuesday, March 25 | 5:00PM - 7:00PM
Signal Response
Room: Nebelhorn

Speaker 3 of 5
Katrin F. Chua, Stanford University Medical Center, USA
Chromatin Regulation and Genome Maintenance by Mammalian SIRT6 and SIRT7

Tuesday, March 25 | 5:00PM - 7:00PM
Signal Response
Room: Nebelhorn

Speaker 4 of 5
Ari M. Melnick, Weill Cornell Medical College, USA
IDH Mutations in Leukemia

Tuesday, March 25 | 5:00PM - 7:00PM
Signal Response
Room: Nebelhorn

Speaker 5 of 5
Anna T. Rolicka, University of Warsaw, Poland
Short Talk: DELLA-Interacting SWI3C Core Subunit of SWI/SNF Chromatin Remodeling Complex Modulates Gibberellin Responses and Hormonal Crosstalk in Arabidopsis

Tuesday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breitachklamm


Tuesday, March 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Nebelhorn


Wednesday, March 26 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Wednesday, March 26 | 8:00AM - 8:30AM
Poster Setup
Room: Nebelhorn


Wednesday, March 26 | 8:30AM - 7:00PM
Poster Viewing
Room: Nebelhorn


Wednesday, March 26 | 8:30AM - 11:30AM
RNA Regulation
Room: Nebelhorn

Speaker 1 of 7
* Edith Heard, European Molecular Biology Laboratory, Germany

Wednesday, March 26 | 8:30AM - 11:30AM
RNA Regulation
Room: Nebelhorn

Speaker 2 of 7
Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Nuclear RNA Processing and Facultative Heterochromatin Assembly

Wednesday, March 26 | 8:30AM - 11:30AM
RNA Regulation
Room: Nebelhorn

Speaker 3 of 7
Peter J. Thompson, University of California, San Francisco, USA
Short Talk: hnRNP K Mediates SETDB1-Dependent Proviral and Gene Repression in ES Cells

Wednesday, March 26 | 8:30AM - 11:30AM
RNA Regulation
Room: Nebelhorn

Speaker 4 of 7
Nicholas J. Proudfoot, University of Oxford, UK
Mechanisms of RNA Polymerase II Termination in Protein Coding and lncRNA Genes

Wednesday, March 26 | 8:30AM - 11:30AM
RNA Regulation
Room: Nebelhorn

Speaker 5 of 7
Ramin Shiekhattar, University of Miami, USA
Long Noncoding RNAs with Enhancer-Like Function in Human Cells

Wednesday, March 26 | 8:30AM - 11:30AM
RNA Regulation
Room: Nebelhorn

Speaker 6 of 7
Robert Schneider, Helmholtz Center Munich, Germany
Short Talk: H2B Methylation, a Guardian of Transposable Elements

Wednesday, March 26 | 8:30AM - 11:30AM
RNA Regulation
Room: Nebelhorn

Speaker 7 of 7
Federica Federici, Erasmus MC, Netherlands
Short Talk: Round Spermatid Injection and X Chromosome Inactivation in Mouse Female Embryos

Wednesday, March 26 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Wednesday, March 26 | 11:30AM - 12:30PM
Lunch
Room: Breitachklamm


Wednesday, March 26 | 12:00PM - 2:30PM
Poster Session 3
Room: Nebelhorn


Wednesday, March 26 | 2:30PM - 4:30PM
Workshop: Epigenetic Therapy/Inhibitors
Room: Nebelhorn

Speaker 1 of 8
* Thomas Jenuwein, Max Planck Institute of Immunobiology and Epigenetics, Germany

Wednesday, March 26 | 2:30PM - 4:30PM
Workshop: Epigenetic Therapy/Inhibitors
Room: Nebelhorn

Speaker 2 of 8
Eugene Yue Dao Chua, Nanyang Technological University, Singapore
Nucleosomal DNA Sequence-Dependent Properties and Targeting by Novel Platinum-Intercalator Species

Wednesday, March 26 | 2:30PM - 4:30PM
Workshop: Epigenetic Therapy/Inhibitors
Room: Nebelhorn

Speaker 3 of 8
Paul Fields, Adaptive Biotechnologies, USA
H2A.Z Functionally Interacts with Tandem Bromodomain Proteins to Activate Genes during ESC Differentiation

Wednesday, March 26 | 2:30PM - 4:30PM
Workshop: Epigenetic Therapy/Inhibitors
Room: Nebelhorn

Speaker 4 of 8
Ruri Kaneda, Jichi Medical University, Japan
Histone Methyltransferase Inhibitor Improves Prognosis in Chronic Heart Failure:
Analysis of Histone H3 Lysine 9 Methylation-Status on Repetitive loci


Wednesday, March 26 | 2:30PM - 4:30PM
Workshop: Epigenetic Therapy/Inhibitors
Room: Nebelhorn

Speaker 5 of 8
Kathryn E. Malecek, Whitehead Institute, USA
Identification and Characterization of Oxidized Methylcytosine Binding Activity in Mammalian Brain

Wednesday, March 26 | 2:30PM - 4:30PM
Workshop: Epigenetic Therapy/Inhibitors
Room: Nebelhorn

Speaker 6 of 8
Anne Schaefer, Mount Sinai School of Medicine, USA
PRC2 Is Essential for Neuronal Function and Survival

Wednesday, March 26 | 2:30PM - 4:30PM
Workshop: Epigenetic Therapy/Inhibitors
Room: Nebelhorn

Speaker 7 of 8
Emma Nilsson, Lund University, Sweden
Genome-Wide Analyses of DNA Methylation and mRNA Expression in Adipose Tissue from Monozygotic Twin Pairs Discordant for Type 2 Diabetes

Wednesday, March 26 | 2:30PM - 4:30PM
Workshop: Epigenetic Therapy/Inhibitors
Room: Nebelhorn

Speaker 8 of 8
Alessio Zippo, Fondazione Istituto Nazionale de Genetica Molecolare-INGM, Italy
MYC Sustains the Wnt Autocrine Loop of ESC by Inducing Epigenetic Silencing of DKK1 and SFRP1 via PRC2 Recruitment

Wednesday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, March 26 | 5:00PM - 7:00PM
Cell Transformation
Room: Nebelhorn

Speaker 1 of 5
* Job Dekker, University of Massachusetts Medical School, USA

Wednesday, March 26 | 5:00PM - 7:00PM
Cell Transformation
Room: Nebelhorn

Speaker 2 of 5
Alexander Tarakhovsky, Rockefeller University, USA
Signaling Function of Polycomb

Wednesday, March 26 | 5:00PM - 7:00PM
Cell Transformation
Room: Nebelhorn

Speaker 3 of 5
Tony Kouzarides, University of Cambridge, UK
Epigenetic Modifications in Transcription and Cancer

Wednesday, March 26 | 5:00PM - 7:00PM
Cell Transformation
Room: Nebelhorn

Speaker 4 of 5
Toshikazu Ushijima, National Cancer Center Research Institute, Japan
Induction Mechanism of Aberrant Epigenetic Modifications by Chronic Inflammation

Wednesday, March 26 | 5:00PM - 7:00PM
Cell Transformation
Room: Nebelhorn

Speaker 5 of 5
Panagiotis Ntziachristos, Northwestern University, USA
Short Talk: Dissecting Important Roles of H3K27 Demethylases in T Cell Leukemia

Wednesday, March 26 | 7:00PM - 7:00PM
On Own for Dinner


Thursday, March 27 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Thursday, March 27 | 8:30AM - 11:45AM
Chromatin Organization
Room: Nebelhorn

Speaker 1 of 7
* Huck-Hui Ng, Genome Institute of Singapore, Singapore

Thursday, March 27 | 8:30AM - 11:45AM
Chromatin Organization
Room: Nebelhorn

Speaker 2 of 7
Bas van Steensel, Netherlands Cancer Institute, Netherlands
Single-Cell Dynamics of Genome - Nuclear Lamina Interactions

Thursday, March 27 | 8:30AM - 11:45AM
Chromatin Organization
Room: Nebelhorn

Speaker 3 of 7
Thomas Jenuwein, Max Planck Institute of Immunobiology and Epigenetics, Germany
Interstitial Heterochromatin in the Mouse Embryonic Stem Cell Epigenome Is Defined by Suv39h-Dependent H3K9me3

Thursday, March 27 | 8:30AM - 11:45AM
Chromatin Organization
Room: Nebelhorn

Speaker 4 of 7
Job Dekker, University of Massachusetts Medical School, USA
Chromosome Folding and Gene Regulation

Thursday, March 27 | 8:30AM - 11:45AM
Chromatin Organization
Room: Nebelhorn

Speaker 5 of 7
Edith Heard, European Molecular Biology Laboratory, Germany
Dynamic Genomic and Epigenomic Landscapes: Lessons from the X-Inactivation Centre

Thursday, March 27 | 8:30AM - 11:45AM
Chromatin Organization
Room: Nebelhorn

Speaker 6 of 7
Florian A. Steiner, University of Geneva, Switzerland
Short Talk: Holocentromeres Are Dispersed Point Centromeres Localized at Transcription Factor Hotspots

Thursday, March 27 | 8:30AM - 11:45AM
Chromatin Organization
Room: Nebelhorn

Speaker 7 of 7
Nabieh Ayoub, Technion -Israel Institute of Technology, Israel
Short Talk: Misregulation of KDM4A-D Histone Demethylases Promotes Chromosomal Instability

Thursday, March 27 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Thursday, March 27 | 11:45AM - 5:00PM
On Own for Lunch and Recreation


Thursday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, March 27 | 5:00PM - 7:15PM
Epigenetic Inheritance
Room: Nebelhorn

Speaker 1 of 6
* Paolo Sassone-Corsi, University of California, Irvine, USA

Thursday, March 27 | 5:00PM - 7:15PM
Epigenetic Inheritance
Room: Nebelhorn

Speaker 2 of 6
Danny F. Reinberg, HHMI/New York University, USA
Polycomb Complexes

Thursday, March 27 | 5:00PM - 7:15PM
Epigenetic Inheritance
Room: Nebelhorn

Speaker 3 of 6
Shelley L. Berger, University of Pennsylvania, USA
Profound Chromatin Changes in Eukaryotic Senescence and Relationship to Aging and Cancer

Thursday, March 27 | 5:00PM - 7:15PM
Epigenetic Inheritance
Room: Nebelhorn

Speaker 4 of 6
Minoo Rassoulzadegan, Université de Nice, France
RNA-Mediated Heredity of Paramutation and Acquired Phenotype in the Mouse

Thursday, March 27 | 5:00PM - 7:15PM
Epigenetic Inheritance
Room: Nebelhorn

Speaker 5 of 6
Eric L. Greer, Harvard Medical School, Boston Children's Hospital, USA
A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C. elegans

Thursday, March 27 | 5:00PM - 7:15PM
Epigenetic Inheritance
Room: Nebelhorn

Speaker 6 of 6
Sarah Kimmins, McGill University, Canada
Short Talk: KDM1A/LSD1 Is Essential for Spermtogonial Stem Cell Differentiation and Survival

Thursday, March 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Breitachklamm


Thursday, March 27 | 8:00PM - 11:00PM
Entertainment
Room: Breitachklamm


Thursday, March 27 | 8:00PM - 11:00PM
Cash Bar
Room: Breitachklamm


Friday, March 28 | 10:25AM - 10:25AM
Departure


*Session Chair.