Web Desc
Exploiting and Understanding Chemical Biotransformations in the Human Microbiome
Organizer(s): Peter J. Turnbaugh, Curtis Huttenhower and Michael A. Fischbach
Date: April 01 - 06, 2014
Location: Big Sky Resort, Big Sky, MT, USA
Supported by the Directors' Fund
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Summary of Meeting:
The aggregate genomes of the trillions of microorganisms associated with the human body, the gut microbiome, extend our own human metabolism through transforming our diet and xenobiotic compounds, including host-targeted drugs and antibiotics. Furthermore, our microbial consortia encode a diverse array of biosynthetic machinery, making them an ideal source of novel natural products. This conference explores the major challenges that are emerging from this new area of study: 1) The biotransformation and resistance to therapeutics; 2) The discovery of natural products from microorganisms, in the context of the human microbiome and other systems; 3) Computational approaches to understanding microbial metabolism and biosynthesis; 4) The potential for synthetic biology to engineer microbiomes; 5) Therapeutic approaches to manipulate the microbiome; 6) Host-microbial signaling mechanisms; and 7) The consequences of microbial biotransformations and toxicity on host health and disease. This conference should foster long-lasting collaborative partnerships between individuals with wide-ranging expertise from both academia and industry. It incorporates the introduction of state-of-the-art techniques to existing areas of research, along with an attempt to identify general biological themes that influence multiple areas of research.
Scholarship Deadline: December 5 2013
Discounted Abstract Deadline: December 5 2013
Abstract Deadline: January 9 2014
Discounted Registration Deadline: February 3 2014
Abstacts when book is in proofing process


We gratefully acknowledge additional support for this conference from:
CrohnIntegrated DNA Technologies
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
EMBO (European Molecular Biology Organization)
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-05
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, April 01 | 4:00PM - 8:00PM
Arrival and Registration
Room: Lower Atrium


Tuesday, April 01 | 6:00PM - 8:00PM
Welcome Mixer
Room: Jefferson


Wednesday, April 02 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Wednesday, April 02 | 8:00AM - 9:00AM
Keynote Address
Room: Jefferson/Madison

Speaker 1 of 2
* Michael A. Fischbach, Stanford University, USA

Wednesday, April 02 | 8:00AM - 9:00AM
Keynote Address
Room: Jefferson/Madison

Speaker 2 of 2
Elaine Holmes, Imperial College London, UK
Trans-Omic Communication in Development and Control of Obesity

Wednesday, April 02 | 9:00AM - 11:30AM
Microbial Interactions with Therapeutics
Room: Jefferson/Madison

Speaker 1 of 5
Gerry D. Wright, McMaster University, Canada
Bacterial Inactivation of Anticancer Drugs

Wednesday, April 02 | 9:00AM - 11:30AM
Microbial Interactions with Therapeutics
Room: Jefferson/Madison

Speaker 2 of 5
Matthew R. Redinbo, University of North Carolina at Chapel Hill, USA
Safely and Selectively Modulating the Mammalian Microbiome

Wednesday, April 02 | 9:00AM - 11:30AM
Microbial Interactions with Therapeutics
Room: Jefferson/Madison

Speaker 3 of 5
Peter J. Turnbaugh, University of California, San Francisco, USA
Contributions of the Human Gut Microbiome to Drug Metabolism

Wednesday, April 02 | 9:00AM - 11:30AM
Microbial Interactions with Therapeutics
Room: Jefferson/Madison

Speaker 4 of 5
Arik Alper, Yale University, USA
Short Talk: The Impact of Human Gut Microbial Community Variation on 5-ASA Metabolism

Wednesday, April 02 | 9:00AM - 11:30AM
Microbial Interactions with Therapeutics
Room: Jefferson/Madison

Speaker 5 of 5
Libusha Kelly, Albert Einstein College of Medicine, USA
Short Talk: Diverse and Mobile beta-Glucuronidases Populate Healthy Human Guts

Wednesday, April 02 | 9:40AM - 10:00AM
Coffee Break
Room: Lower Atrium


Wednesday, April 02 | 11:30AM - 12:45PM
NIH Resources and Funding Opportunities to Support Microbiom
e-Related Research
Room: Madison/Jefferson
The goals of the session are (1) to provide an overview of NIH programs, resources, and funding opportunities to support research on understanding how the microbiome contributes to health and disease and (2) to provide a forum for participants to meet and interact with NIH program officials through discussion.



The workshop will include an introduction and brief presentations by NIH program staff on specific programs and funding opportunities, followed by discussions where participants can interact with NIH program staff in small groups.

Speaker 1 of 1
* Padma Maruvada, NIDDK, National Institutes of Health, USA

Wednesday, April 02 | 11:30AM - 1:00PM
Poster Setup
Room: Gallatin


Wednesday, April 02 | 12:45PM - 5:00PM
On Own for Lunch and Recreation


Wednesday, April 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Wednesday, April 02 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Wednesday, April 02 | 5:00PM - 7:00PM
Biosynthesis of Small Molecules and Drug Discovery
Room: Jefferson/Madison

Speaker 1 of 4
* Gerry D. Wright, McMaster University, Canada

Wednesday, April 02 | 5:00PM - 7:00PM
Biosynthesis of Small Molecules and Drug Discovery
Room: Jefferson/Madison

Speaker 2 of 4
Emily P. Balskus, Harvard University, USA
Discovery and Characterization of Disease-Associated Metabolic Pathways within the Human Gut Microbiota

Wednesday, April 02 | 5:00PM - 7:00PM
Biosynthesis of Small Molecules and Drug Discovery
Room: Jefferson/Madison

Speaker 3 of 4
Michael A. Fischbach, Stanford University, USA
Insights from a Global View of Secondary Metabolism: Small Molecules from the Human Microbiota

Wednesday, April 02 | 5:00PM - 7:00PM
Biosynthesis of Small Molecules and Drug Discovery
Room: Jefferson/Madison

Speaker 4 of 4
Philip P. Strandwitz, Northeastern University, USA
Short Talk: GABA Is a Growth Factor for Uncultured Bacteria from the Human Gut Microbiome

Wednesday, April 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Gallatin


Wednesday, April 02 | 7:30PM - 10:00PM
Poster Session 1
Room: Gallatin


Thursday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Thursday, April 03 | 8:00AM - 11:15AM
Computational Approaches to Understanding Microbial Metaboli
sm and Biosynthesis

Room: Jefferson/Madison

Speaker 1 of 7
* Aleksandar David Kostic, Broad Institute, USA

Thursday, April 03 | 8:00AM - 11:15AM
Computational Approaches to Understanding Microbial Metaboli
sm and Biosynthesis

Room: Jefferson/Madison

Speaker 2 of 7
Elhanan Borenstein, University of Washington, USA
Metegenomic Systems Biology: Toward a Predictive Systems-Level Model of the Human Microbiome

Thursday, April 03 | 8:00AM - 11:15AM
Computational Approaches to Understanding Microbial Metaboli
sm and Biosynthesis

Room: Jefferson/Madison

Speaker 3 of 7
João B. Xavier, Memorial Sloan-Kettering Cancer Center, USA
Modeling Intestinal Microbiota Dynamics during Antibiotic Treatment

Thursday, April 03 | 8:00AM - 11:15AM
Computational Approaches to Understanding Microbial Metaboli
sm and Biosynthesis

Room: Jefferson/Madison

Speaker 4 of 7
Curtis Huttenhower, Harvard School of Public Health, USA
Multi'omic Characterization of the Gut Microbial Ecosystem for Diagnosis and Therapy in Inflammatory Disease

Thursday, April 03 | 8:00AM - 11:15AM
Computational Approaches to Understanding Microbial Metaboli
sm and Biosynthesis

Room: Jefferson/Madison

Speaker 5 of 7
Rob Knight, University of California, San Diego, USA
Microbial Communities Viewed Over Time and Space

Thursday, April 03 | 8:00AM - 11:15AM
Computational Approaches to Understanding Microbial Metaboli
sm and Biosynthesis

Room: Jefferson/Madison

Speaker 6 of 7
Patrick H. Bradley, Gladstone Institutes, USA
Short Talk: Assessing the Stability of Protein Family Abundance in the Gut Microbiome

Thursday, April 03 | 8:00AM - 11:15AM
Computational Approaches to Understanding Microbial Metaboli
sm and Biosynthesis

Room: Jefferson/Madison

Speaker 7 of 7
Dan B. Knights, University of Minnesota, USA
Short Talk: Linking Complex Host Genetics to Bacterial Dysbiosis in Inflammatory Bowel Disease

Thursday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Thursday, April 03 | 11:15AM - 1:00PM
Poster Setup
Room: Gallatin


Thursday, April 03 | 11:15AM - 2:30PM
On Own for Lunch and Recreation


Thursday, April 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Thursday, April 03 | 1:30PM - 4:30PM
Workshop: Bioinformatics Tools (a Tutorial)
Room: Jefferson/Madison

Speaker 1 of 4
* Curtis Huttenhower, Harvard School of Public Health, USA
HUMAnN v2/ShortBRED

Thursday, April 03 | 1:30PM - 4:30PM
Workshop: Bioinformatics Tools (a Tutorial)
Room: Jefferson/Madison

Speaker 2 of 4
Morgan Langille, Dalhousie University, Canada
PICRUSt/STAMP

Thursday, April 03 | 1:30PM - 4:30PM
Workshop: Bioinformatics Tools (a Tutorial)
Room: Jefferson/Madison

Speaker 3 of 4
Elhanan Borenstein, University of Washington, USA
Metabolic Modeling

Thursday, April 03 | 1:30PM - 4:30PM
Workshop: Bioinformatics Tools (a Tutorial)
Room: Jefferson/Madison

Speaker 4 of 4
Rob Knight, University of California, San Diego, USA
Evident/Qiita

Thursday, April 03 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Thursday, April 03 | 5:00PM - 7:00PM
Impacts on Host Health and Disease
Room: Jefferson/Madison

Speaker 1 of 5
* Heidi H. Kong, National Institutes of Health, USA

Thursday, April 03 | 5:00PM - 7:00PM
Impacts on Host Health and Disease
Room: Jefferson/Madison

Speaker 2 of 5
Christian Jobin, University of Florida, USA
Interaction between Genotoxic Bacteria and Host Environment Influences Colorectal Cancer Development

Thursday, April 03 | 5:00PM - 7:00PM
Impacts on Host Health and Disease
Room: Jefferson/Madison

Speaker 3 of 5
Stanley L. Hazen, Cleveland Clinical Foundation, USA
Links between Microbial Metabolism of Dietary Choline and Atherosclerosis

Thursday, April 03 | 5:00PM - 7:00PM
Impacts on Host Health and Disease
Room: Jefferson/Madison

Speaker 4 of 5
Eugene B. Chang, University of Chicago, USA
Diet, Microbes and Genetics: The Perfect Storm to Inflammatory Bowel Diseases

Thursday, April 03 | 5:00PM - 7:00PM
Impacts on Host Health and Disease
Room: Jefferson/Madison

Speaker 5 of 5
Elaine Y. Hsiao, University of California, Los Angeles, USA
Short Talk: A Commensal Bacterium of the Gut Microbiome Modulates Serum Metabolites and Ameliorates Behavioral Abnormalities in a Mouse Model of an Autism Risk Factor

Thursday, April 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Gallatin


Thursday, April 03 | 7:30PM - 10:00PM
Poster Session 2
Room: Gallatin


Friday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Friday, April 04 | 8:00AM - 11:00AM
Engineering Microbiomes
Room: Jefferson/Madison

Speaker 1 of 6
* Curtis Huttenhower, Harvard School of Public Health, USA

Friday, April 04 | 8:00AM - 11:00AM
Engineering Microbiomes
Room: Jefferson/Madison

Speaker 2 of 6
Sean Davies, Vanderbilt University, USA
Genetically Engineered Therapeutic Bacteria

Friday, April 04 | 8:00AM - 11:00AM
Engineering Microbiomes
Room: Jefferson/Madison

Speaker 3 of 6
Christopher Voigt, Massachusetts Institute of Technology, USA
Synthetic Metagenomics

Friday, April 04 | 8:00AM - 11:00AM
Engineering Microbiomes
Room: Jefferson/Madison

Speaker 4 of 6
Tom Van de Wiele, Ghent University, Belgium
Simulating the Human Gut Microbiome

Friday, April 04 | 8:00AM - 11:00AM
Engineering Microbiomes
Room: Jefferson/Madison

Speaker 5 of 6
Liang Ma, California Institute of Technology, USA
Short Talk: Using Microfluidics for Genetically Targeted Cultivation Validated by Isolation of a “Most Wanted” Microbe from the Human Gut

Friday, April 04 | 8:00AM - 11:00AM
Engineering Microbiomes
Room: Jefferson/Madison

Speaker 6 of 6
Yannan Zhao, The Scripps Research Institute, USA
Short Talk: Self-Assembling Cyclic Peptides for Modulating the Gut Microbiome to Treat Atherosclerosis

Friday, April 04 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Friday, April 04 | 11:00AM - 1:00PM
Poster Setup
Room: Gallatin


Friday, April 04 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Friday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Gallatin


Friday, April 04 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Friday, April 04 | 5:00PM - 7:15PM
Therapeutics Approaches to Manipulating the Microbiome
Room: Jefferson/Madison

Speaker 1 of 5
* Matthew R. Redinbo, University of North Carolina at Chapel Hill, USA

Friday, April 04 | 5:00PM - 7:15PM
Therapeutics Approaches to Manipulating the Microbiome
Room: Jefferson/Madison

Speaker 2 of 5
Nathalie Delzenne, Université Catholique de Louvain, Belgium
Prebiotic Approach: A Nutrition-Based Therapy to Tackle Metabolic Diseases Related to Malnutrition

Friday, April 04 | 5:00PM - 7:15PM
Therapeutics Approaches to Manipulating the Microbiome
Room: Jefferson/Madison

Speaker 3 of 5
Alexander Khoruts, University of Minnesota, USA
Human Fecal Microbiota Transplantation in Treatment of Clostridium difficile Infection: Metabolic Effects of Engraftment

Friday, April 04 | 5:00PM - 7:15PM
Therapeutics Approaches to Manipulating the Microbiome
Room: Jefferson/Madison

Speaker 4 of 5
Petra Louis, University of Aberdeen, UK
Dietary Modulation of the Gut Microbiota and Metabolism

Friday, April 04 | 5:00PM - 7:15PM
Therapeutics Approaches to Manipulating the Microbiome
Room: Jefferson/Madison

Speaker 5 of 5
Liping Zhao, Shanghai Jiao Tong University, China and Rutgers University, USA
Can We Follow Koch's Postulates for Hunting Down Human Obesity Bugs in Gut Microbiota?

Friday, April 04 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Gallatin


Friday, April 04 | 7:30PM - 10:00PM
Poster Session 3
Room: Gallatin


Saturday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: Gallatin


Saturday, April 05 | 8:00AM - 11:15AM
Host-Microbial Interactions
Room: Jefferson/Madison

Speaker 1 of 7
* Elaine Y. Hsiao, University of California, Los Angeles, USA

Saturday, April 05 | 8:00AM - 11:15AM
Host-Microbial Interactions
Room: Jefferson/Madison

Speaker 2 of 7
Heidi H. Kong, National Institutes of Health, USA
Host-Microbial Interactions in Healthy Skin and Dermatologic Disorders

Saturday, April 05 | 8:00AM - 11:15AM
Host-Microbial Interactions
Room: Jefferson/Madison

Speaker 3 of 7
Margaret J. McFall-Ngai, University of Hawai‘i at Manoa, USA
Evolutionarily Conserved Signals of Host-Microbe Interaction: Lessons from the Squid-Vibrio Symbiosis

Saturday, April 05 | 8:00AM - 11:15AM
Host-Microbial Interactions
Room: Jefferson/Madison

Speaker 4 of 7
Katherine P. Lemon, Forsyth Institute, USA
Nose Picking for Progress: Mining Nasal Microbiota for New Insights into Pathobionts

Saturday, April 05 | 8:00AM - 11:15AM
Host-Microbial Interactions
Room: Jefferson/Madison

Speaker 5 of 7
Sven Pettersson, Nanyang Technological University, Singapore
The Maternal Microbiome Influence Placenta Development and Function which can Influence Brain Function Later in Life

Saturday, April 05 | 8:00AM - 11:15AM
Host-Microbial Interactions
Room: Jefferson/Madison

Speaker 6 of 7
Charisse Petersen, University of Utah, USA
Short Talk: Direct Detection of the Microbiota by T Cells Prevents Pathobiont Expansion to Maintain Homeostasis

Saturday, April 05 | 8:00AM - 11:15AM
Host-Microbial Interactions
Room: Jefferson/Madison

Speaker 7 of 7
Tim D. Spector, King's College London, UK
Short Talk: Host Genetic Control of the Human Gut Microbiome: A Twin Study

Saturday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Saturday, April 05 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Saturday, April 05 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Saturday, April 05 | 5:00PM - 6:15PM
Unintended Consequences of Antibiotic Use
Room: Jefferson/Madison

Speaker 1 of 3
* Peter J. Turnbaugh, University of California, San Francisco, USA

Saturday, April 05 | 5:00PM - 6:15PM
Unintended Consequences of Antibiotic Use
Room: Jefferson/Madison

Speaker 2 of 3
Tami Lieberman, Massachusetts Institute of Technology, USA
Genomic Evolution and Diversification of a Pathogen within the Patient

Saturday, April 05 | 5:00PM - 6:15PM
Unintended Consequences of Antibiotic Use
Room: Jefferson/Madison

Speaker 3 of 3
Martin J. Blaser, New York University School of Medicine, USA
Early Life Exposure to Antibiotics Changes Developmental Phenotypes

Saturday, April 05 | 6:15PM - 7:15PM
Closing Keynote Address
Room: Jefferson/Madison

Speaker 1 of 1
David A. Relman, Stanford University, USA
Stability and Resilience in the Human Microbiome

Saturday, April 05 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Gallatin


Saturday, April 05 | 8:00PM - 11:00PM
Entertainment
Room: Gallatin


Saturday, April 05 | 8:00PM - 11:00PM
Cash Bar
Room: Gallatin


Sunday, April 06 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.