Web Desc
Epigenetic Programming and Inheritance
Organizer(s): Joseph H. Nadeau, Marisa S. Bartolomei, Peter Gluckman and Wolf Reik
Date: April 06 - 10, 2014
Location: Boston Park Plaza, Boston, MA, USA
Supported by the Directors' Fund
Summary of Meeting:
Epigenetics is emerging as a fundamentally important area of biological and medical research with implications for our understanding of developmental and physiological processes, for childhood and adult disease, as well as for an unexpected and important new mode of inheritance. Epigenetics deals with phenotypic changes that are independent of the underlying DNA sequence. These mechanisms modulate gene expression, RNA biology and protein function throughout development and adulthood and are strongly influenced by both genetic and environmental factors. Anomalies can lead to birth defects, metabolic disease, cancer and behavioral changes. Recent evidence shows that epigenetic features can be transmitted across generations, suggesting that molecular changes in addition to DNA sequence differences control phenotypic variation and disease risk and therefore that epigenetics might be as important as genetics in organismal biology. This meeting will bring together both established researchers and rising stars; for the first time individuals focusing on molecular mechanisms can interact with those studying population consequences, with the hope that these two communities will begin to work together to understand epigenetics in the context of health and disease.
Scholarship Deadline: December 5 2013
Discounted Abstract Deadline: December 5 2013
Abstract Deadline: January 14 2014
Discounted Registration Deadline: February 4 2014
We gratefully acknowledge additional support for this conference from:
Development, The Company of Biologists LtdEscher Fund for AutismLandes BioscienceMarch of Dimes Foundation Grant No. 4-FY14-469Zymo Research Corporation
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
EMBO (European Molecular Biology Organization)
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 06 | 4:00PM - 8:00PM
Arrival and Registration
Room: Imperial Check Room


Sunday, April 06 | 6:00PM - 8:00PM
Welcome Mixer
Room: Statler Room


Monday, April 07 | 7:30AM - 8:30AM
Breakfast
Room: Plaza Ballroom


Monday, April 07 | 8:00AM - 8:30AM
Poster Setup
Room: Plaza Ballroom


Monday, April 07 | 8:30AM - 11:45AM
Epigenetic and Epigenomic Mechanisms I.
Session sponso

red by the journal, Development.

Room: Imperial Ballroom
Support for these organizer-selected speakers generously provided by this journal.
Speaker 8 of 8
Jerome Jullien, CRUK Wellcome Trust Gurdon Institute, UK
Short Talk: Sperm Is Programmed to Support Transcription of Developmentally-Important Embryonic Genes

Monday, April 07 | 8:30AM - 11:45AM
Epigenetic and Epigenomic Mechanisms I.
Session sponso

red by the journal, Development.

Room: Imperial Ballroom
Support for these organizer-selected speakers generously provided by this journal.
Speaker 7 of 8
Bluma J. Lesch, Whitehead Institute for Biomedical Research, USA
Short Talk: Genes Central to Embryogenesis Retain a Poised Chromatin State during Mammalian Germ Cell Development

Monday, April 07 | 8:30AM - 11:45AM
Epigenetic and Epigenomic Mechanisms I.
Session sponso

red by the journal, Development.

Room: Imperial Ballroom
Support for these organizer-selected speakers generously provided by this journal.
Speaker 6 of 8
Antoine H.F.M. Peters, Friedrich Miescher Institute for Biomedical Research, Switzerland
Epigenetic Control of Mammalian Germ Line and Early Embryonic Development

Monday, April 07 | 8:30AM - 11:45AM
Epigenetic and Epigenomic Mechanisms I.
Session sponso

red by the journal, Development.

Room: Imperial Ballroom
Support for these organizer-selected speakers generously provided by this journal.
Speaker 5 of 8
Alexander Meissner, Max Planck Institute for Molecular Genetics, Germany
DNA Methylation Dynamics in Stem Cells and Development

Monday, April 07 | 8:30AM - 11:45AM
Epigenetic and Epigenomic Mechanisms I.
Session sponso

red by the journal, Development.

Room: Imperial Ballroom
Support for these organizer-selected speakers generously provided by this journal.
Speaker 4 of 8
Gavin D. Kelsey, Babraham Institute, UK
DNA Methylation Establishment in the Germline

Monday, April 07 | 8:30AM - 11:45AM
Epigenetic and Epigenomic Mechanisms I.
Session sponso

red by the journal, Development.

Room: Imperial Ballroom
Support for these organizer-selected speakers generously provided by this journal.
Speaker 3 of 8
Wolf Reik, Babraham Institute, UK
The Role of DNA Modifications in Epigenetic Reprogramming and Signaling

Monday, April 07 | 8:30AM - 11:45AM
Epigenetic and Epigenomic Mechanisms I.
Session sponso

red by the journal, Development.

Room: Imperial Ballroom
Support for these organizer-selected speakers generously provided by this journal.
Speaker 2 of 8
* Bradley R. Cairns, HHMI/University of Utah, USA

Monday, April 07 | 8:30AM - 11:45AM
Epigenetic and Epigenomic Mechanisms I.
Session sponso

red by the journal, Development.

Room: Imperial Ballroom
Support for these organizer-selected speakers generously provided by this journal.
Speaker 1 of 8
Joseph H. Nadeau, Maine Medical Center Research Institute, USA
Introduction and Welcome Remarks

Monday, April 07 | 8:30AM - 5:00PM
Poster Viewing
Room: Plaza Ballroom


Monday, April 07 | 9:50AM - 10:10AM
Coffee Break
Room: Plaza Ballroom


Monday, April 07 | 11:45AM - 12:30PM
Lunch
Room: Plaza Ballroom


Monday, April 07 | 12:00PM - 2:30PM
Poster Session 1
Room: Plaza Ballroom


Monday, April 07 | 4:30PM - 5:00PM
Coffee Available
Room: Plaza Ballroom


Monday, April 07 | 5:00PM - 7:00PM
Epigenetic and Epigenomic Mechanisms II
Room: Imperial Ballroom

Speaker 4 of 4
Eric L. Greer, Harvard Medical School, Boston Children's Hospital, USA
Short Talk: A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C. elegans

Monday, April 07 | 5:00PM - 7:00PM
Epigenetic and Epigenomic Mechanisms II
Room: Imperial Ballroom

Speaker 3 of 4
Mitinori Saitou, Graduate School of Medicine, Kyoto University, Japan
Mechanism and Reconstitution in vitro of Germ Cell Development in Mice

Monday, April 07 | 5:00PM - 7:00PM
Epigenetic and Epigenomic Mechanisms II
Room: Imperial Ballroom

Speaker 2 of 4
Bradley R. Cairns, HHMI/University of Utah, USA
Chromatin Strategies for Maintaining Pluripotency in Adult Germline Stem Cells and Mammalian Spermatogenesis


Monday, April 07 | 5:00PM - 7:00PM
Epigenetic and Epigenomic Mechanisms II
Room: Imperial Ballroom

Speaker 1 of 4
* Wolf Reik, Babraham Institute, UK

Monday, April 07 | 7:00PM - 7:00PM
On Own for Dinner


Tuesday, April 08 | 7:30AM - 8:30AM
Breakfast
Room: Plaza Ballroom


Tuesday, April 08 | 8:30AM - 11:45AM
Transgenerational Inheritance and Imprinting I
Room: Imperial Ballroom

Speaker 1 of 7
* Joseph H. Nadeau, Maine Medical Center Research Institute, USA

Tuesday, April 08 | 8:30AM - 11:45AM
Transgenerational Inheritance and Imprinting I
Room: Imperial Ballroom

Speaker 2 of 7
Marisa S. Bartolomei, University of Pennsylvania Perelman School of Medicine, USA
Endocrine Disrupting Chemicals Exposure in Mouse: Genomic Imprinting, Physiology and Transgenerational Inheritance

Tuesday, April 08 | 8:30AM - 11:45AM
Transgenerational Inheritance and Imprinting I
Room: Imperial Ballroom

Speaker 3 of 7
Anne C. Ferguson-Smith, University of Cambridge, UK
Genomic Imprinting

Tuesday, April 08 | 8:30AM - 11:45AM
Transgenerational Inheritance and Imprinting I
Room: Imperial Ballroom

Speaker 4 of 7
John A. Stamatoyannopoulos, Altius Institute for Biomedical Sciences, USA
Epigenetics and GWAS

Tuesday, April 08 | 8:30AM - 11:45AM
Transgenerational Inheritance and Imprinting I
Room: Imperial Ballroom

Speaker 5 of 7
Anne Brunet, Stanford University, USA
Metabolic and Epigenetic Regulation of Aging

Tuesday, April 08 | 8:30AM - 11:45AM
Transgenerational Inheritance and Imprinting I
Room: Imperial Ballroom

Speaker 6 of 7
Nicole L. Yohn, University of Pennsylvania, Perelman School of Medicine, USA
Short Talk: The Multigenerational Interaction of Nicotine and Chronic Stress on Anxiety and Stress Sensitivity in Mice

Tuesday, April 08 | 8:30AM - 11:45AM
Transgenerational Inheritance and Imprinting I
Room: Imperial Ballroom

Speaker 7 of 7
Brian G. Dias, Emory University, USA
Short Talk: Transgenerational Inheritance of Ancestral Olfactory Experience

Tuesday, April 08 | 9:50AM - 10:10AM
Coffee Break
Room: Plaza Ballroom


Tuesday, April 08 | 11:45AM - 12:45PM
Career Development Workshop - 'How to Choose Your Next Lab o
r Workplace'
Room: Imperial Ballroom
'Choose Your Next Lab or Workplace'Grad students and postdocs frequently don't choose a lab as if it were a major career decision, yet they spend 4-7 years working for one person in a small group. Choosing a lab is definitely worth a little preparation to make sure it will be a good fit and get junior investigators close to where they want to go in the future. This presentation gives practical tips about what to look for and how to find it when choosing a new lab. While geared to junior scientists, this talk will also help advisors understand their lab culture. Presented by Joanne Kamens, Ph.D., Executive Director, Addgene.

Tuesday, April 08 | 11:45AM - 1:00PM
Poster Setup
Room: Plaza Ballroom


Tuesday, April 08 | 11:45AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, April 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Plaza Ballroom


Tuesday, April 08 | 4:30PM - 5:00PM
Coffee Available
Room: Plaza Ballroom


Tuesday, April 08 | 5:00PM - 7:00PM
Transgenerational Inheritance and Imprinting II
Room: Imperial Ballroom

Speaker 1 of 5
* Marisa S. Bartolomei, University of Pennsylvania Perelman School of Medicine, USA

Tuesday, April 08 | 5:00PM - 7:00PM
Transgenerational Inheritance and Imprinting II
Room: Imperial Ballroom

Speaker 2 of 5
Oliver J. Rando, University of Massachusetts Medical School, USA
Paternal Effects on Gene Regulation in Mammals

Tuesday, April 08 | 5:00PM - 7:00PM
Transgenerational Inheritance and Imprinting II
Room: Imperial Ballroom

Speaker 3 of 5
Ueli Grossniklaus, University of Zürich, Switzerland
Epigenetic Maternal Regulation of Seed Development

Tuesday, April 08 | 5:00PM - 7:00PM
Transgenerational Inheritance and Imprinting II
Room: Imperial Ballroom

Speaker 4 of 5
Joseph H. Nadeau, Maine Medical Center Research Institute, USA
The Genetics of Epigenetic Inheritance

Tuesday, April 08 | 5:00PM - 7:00PM
Transgenerational Inheritance and Imprinting II
Room: Imperial Ballroom

Speaker 5 of 5
Louise E. Docherty, University of Southampton, UK
Short Talk: Using Genome-Wide DNA Methylation Analysis of Patients with Complex Imprinting Disorders to Identify Novel Candidate Imprinted Genes

Tuesday, April 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Plaza Ballroom


Tuesday, April 08 | 7:30PM - 10:00PM
Poster Session 2
Room: Plaza Ballroom


Wednesday, April 09 | 7:30AM - 8:30AM
Breakfast
Room: Plaza Ballroom


Wednesday, April 09 | 8:30AM - 11:30AM
Developmental Origins and Epigenetic Epidemiology I
Room: Imperial Ballroom

Speaker 1 of 6
* Terrence Forrester, University of the West Indies, Jamaica

Wednesday, April 09 | 8:30AM - 11:30AM
Developmental Origins and Epigenetic Epidemiology I
Room: Imperial Ballroom

Speaker 2 of 6
Peter Gluckman, University of Auckland, New Zealand
Epigenetic Epidemiology: Its Application to the Challenge of the Developmental Origins of Health and Disease Hypothesis

Wednesday, April 09 | 8:30AM - 11:30AM
Developmental Origins and Epigenetic Epidemiology I
Room: Imperial Ballroom

Speaker 3 of 6
Caroline L. Relton, Newcastle University, UK
Epigenetic Biomarkers and Causality in Complex Disease

Wednesday, April 09 | 8:30AM - 11:30AM
Developmental Origins and Epigenetic Epidemiology I
Room: Imperial Ballroom

Speaker 4 of 6
Jonathan Mill, University of Exeter Medical School and King's College London, UK
Epigenetic Trajectories to Neuropsychiatric Disease

Wednesday, April 09 | 8:30AM - 11:30AM
Developmental Origins and Epigenetic Epidemiology I
Room: Imperial Ballroom

Speaker 5 of 6
Bas T. Heijmans, Leiden University Medical Centre, Netherlands
The Prenatal Epigenome and Studies into Long-Term Health

Wednesday, April 09 | 8:30AM - 11:30AM
Developmental Origins and Epigenetic Epidemiology I
Room: Imperial Ballroom

Speaker 6 of 6
Soetkin Versteyhe, Copenhagen University, Denmark
Short Talk: Obese Human have an Altered Spermatozoal Small RNA Expression Profile - Possible Contributors of Epigenetic Inheritance

Wednesday, April 09 | 9:50AM - 10:10AM
Coffee Break
Room: Plaza Ballroom


Wednesday, April 09 | 11:30AM - 12:00PM
Workshop on Biological Applications of Epigenetics
Room: Imperial Ballroom
Epigenetics methods and thinking are increasingly applied in many areas of exciting contemporary biology, such as developmental programming, neurosciences, and metabolic disorders. This discussion session explores links between the disciplines and how choice of methods and quality standards is important so that results can be widely compared, increasing confidence in the conclusions.
Speaker 1 of 2
* Marisa S. Bartolomei, University of Pennsylvania Perelman School of Medicine, USA

Wednesday, April 09 | 11:30AM - 12:00PM
Workshop on Biological Applications of Epigenetics
Room: Imperial Ballroom
Epigenetics methods and thinking are increasingly applied in many areas of exciting contemporary biology, such as developmental programming, neurosciences, and metabolic disorders. This discussion session explores links between the disciplines and how choice of methods and quality standards is important so that results can be widely compared, increasing confidence in the conclusions.
Speaker 2 of 2
* Wolf Reik, Babraham Institute, UK

Wednesday, April 09 | 12:00PM - 5:00PM
On Own for Lunch and Recreation


Wednesday, April 09 | 4:30PM - 5:00PM
Coffee Available
Room: Plaza Ballroom


Wednesday, April 09 | 5:00PM - 7:00PM
Developmental Origins and Epigenetic Epidemiology II
Room: Imperial Ballroom

Speaker 1 of 6
* Peter Gluckman, University of Auckland, New Zealand

Wednesday, April 09 | 5:00PM - 7:00PM
Developmental Origins and Epigenetic Epidemiology II
Room: Imperial Ballroom

Speaker 2 of 6
Terrence Forrester, University of the West Indies, Jamaica
Long-Term Consequences of Early-Life Malnutrition: Developmental Context

Wednesday, April 09 | 5:00PM - 7:00PM
Developmental Origins and Epigenetic Epidemiology II
Room: Imperial Ballroom

Speaker 3 of 6
Cheryl L. Walker, Baylor College of Medicine, USA
Developmental (re)Programming by Endocrine Disruptors: Environmental Cross-Talk with the Epigenetic Machinery

Wednesday, April 09 | 5:00PM - 7:00PM
Developmental Origins and Epigenetic Epidemiology II
Room: Imperial Ballroom

Speaker 4 of 6
Krishnendu Mukherjee, University of Applied Sciences Mittelhessen, Germany
Short Talk: Epigenetic Changes during Pathogen Infections, Trans-Generational Immune Priming and Metamorphosis in the Insect Model Galleria Mellonella

Wednesday, April 09 | 5:00PM - 7:00PM
Developmental Origins and Epigenetic Epidemiology II
Room: Imperial Ballroom

Speaker 5 of 6
Marine Baptissart, INSERM, France
Short Talk: Paternal Bile Acids Exposure: a Dark Messenger throughout Generations

Wednesday, April 09 | 5:00PM - 7:00PM
Developmental Origins and Epigenetic Epidemiology II
Room: Imperial Ballroom

Speaker 6 of 6
Mara C. Inniss, Obsidian Therapeutics, USA
Short Talk: Synthetic Cellular Memory for Tracking Human Cell Fate

Wednesday, April 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Plaza Ballroom


Wednesday, April 09 | 8:00PM - 11:00PM
Entertainment
Room: Plaza Ballroom


Wednesday, April 09 | 8:00PM - 11:00PM
Cash Bar
Room: Plaza Ballroom


Thursday, April 10 | 10:25AM - 10:25AM
Departure


*Session Chair.