Web Desc
The Brain: Adaptation and Maladaptation in Chronic Pain
Organizer(s): Frank Porreca, David Borsook and David W. Dodick
Date: June 15 - 20, 2014
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Regeneron Pharmaceuticals, Inc.
Summary of Meeting:
SIGNIFICANCE: The Institutes of Medicine indicate that pain affects more than 100 million Americans and costs more than an estimated $540-630 billion, a number predicted to only increase as our population ages and is influenced by lifestyle. We have few effective treatments for migraine or chronic pain. GOALS: Understanding the complexities of brain circuits involved in pain and migraine headache has been a major challenge in neurobiology that has limited the discovery of new therapies. For decades, the pain and headache communities have separately focused on peripheral mechanisms. INNOVATION: This conference brings together the world’s leading experts in brain systems neuroscience to highlight the advances in understanding brain systems relevant to the neurobiology of migraine and chronic pain. We wish to explore neurobiology of pain and headache together with contributions and attendance from both communities. APPROACH: A conversation of a number of new technologies has opened new opportunities to better understand the neural networks involved in the emotional, cognitive and sensory components of pain and consequent suffering. New technologies have opened doors to revolutionize our concepts of the impact of pain on the brain. OPPORTUNITY: Bringing together scientists from different disciplines related to, but not exclusively connected to pain and headache as a key to integration and bridging of disciplines and advancement of knowledge in these areas of clinical need. Accumulating functional and imaging data implicate headache and chronic pains as diseases of the brain – either primarily or secondarily as a consequence of peripheral damage. OUTCOME: We are at an exciting moment in the neurosciences where new understanding of brain function promises to change paradigms for drug discovery for neurological disorders. The promise is great, and the next decade of brain sciences research will redefine disease states, including predictive and personalized medicine, allow imaging the brain during pain and its relief by treatments in the individual patients suffering from pain.
Scholarship Deadline: February 13 2014
Discounted Abstract Deadline: February 13 2014
Abstract Deadline: March 13 2014
Discounted Registration Deadline: April 30 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Regeneron Pharmaceuticals, Inc.
We gratefully acknowledge additional support for this conference from:
Educational grant from Lilly
$2,500 - $9,999

SAGE: Cephalalgia, published by SAGE on behalf of the International Headache Society
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

SAGE: Cephalalgia
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS087854-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, June 15 | 4:00PM - 8:00PM
Arrival and Registration
Room: Lakeside Suite


Sunday, June 15 | 6:00PM - 8:00PM
Mixer
Room: Gallery


Monday, June 16 | 7:30AM - 8:30AM
Breakfast
Room: Bighorn Room


Monday, June 16 | 8:30AM - 8:45AM
Opening Remarks
Room: Lodge Ballroom

Speaker 1 of 3
David W. Dodick, Mayo Clinic, USA

Monday, June 16 | 8:30AM - 8:45AM
Opening Remarks
Room: Lodge Ballroom

Speaker 2 of 3
David Borsook, Children's Hospital, USA

Monday, June 16 | 8:30AM - 8:45AM
Opening Remarks
Room: Lodge Ballroom

Speaker 3 of 3
Frank Porreca, University of Arizona, USA

Monday, June 16 | 8:45AM - 9:45AM
Keynote Address
Room: Lodge Ballroom

Speaker 1 of 2
* Frank Porreca, University of Arizona, USA

Monday, June 16 | 8:45AM - 9:45AM
Keynote Address
Room: Lodge Ballroom

Speaker 2 of 2
Michael W. Salter, Hospital for Sick Children and University of Toronto, Canada
Neuron-Glia Signaling in Pain Neuroplasticity

Monday, June 16 | 9:45AM - 12:15PM
Plasticity of Brain Neurons, Glia and Other Processes
Room: Lodge Ballroom

Speaker 1 of 6
* Stephen B. McMahon, King's College London, UK

Monday, June 16 | 9:45AM - 12:15PM
Plasticity of Brain Neurons, Glia and Other Processes
Room: Lodge Ballroom

Speaker 2 of 6
Ru-Rong Ji, Duke University, USA
Microglial and Astroglial Signaling in Persistent Pain

Monday, June 16 | 9:45AM - 12:15PM
Plasticity of Brain Neurons, Glia and Other Processes
Room: Lodge Ballroom

Speaker 3 of 6
Magdalena Luciuk, University of Sydney, Australia
Short Talk: Microglial Phenotype in the Medullary Reticular Region in Chronic Pain

Monday, June 16 | 9:45AM - 12:15PM
Plasticity of Brain Neurons, Glia and Other Processes
Room: Lodge Ballroom

Speaker 4 of 6
Manuel Graeber, University of Sydney, Australia
What Is Neuroinflammation?

Monday, June 16 | 9:45AM - 12:15PM
Plasticity of Brain Neurons, Glia and Other Processes
Room: Lodge Ballroom

Speaker 5 of 6
Amanda L. Ellis, University of Colorado, USA
Short Talk: Administering Morphine following Spinal Cord Injury Amplifies Central Neuropathic Pain

Monday, June 16 | 9:45AM - 12:15PM
Plasticity of Brain Neurons, Glia and Other Processes
Room: Lodge Ballroom

Speaker 6 of 6
Giorgio A. Ascoli, George Mason University, USA
Neuronal Morphology Goes Digital: A Research Hub for Cellular and System Neuroscience

Monday, June 16 | 10:10AM - 10:30AM
Coffee Break
Room: Gallery


Monday, June 16 | 12:15PM - 1:00PM
Poster Setup
Room: Lodge Ballroom


Monday, June 16 | 12:15PM - 2:00PM
On Own for Lunch


Monday, June 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Lodge Ballroom


Monday, June 16 | 2:00PM - 3:30PM
Workshop: New Technologies to Understand the Brain in Pain
Room: Lodge Ballroom

Speaker 1 of 5
* David Borsook, Children's Hospital, USA

Monday, June 16 | 2:00PM - 3:30PM
Workshop: New Technologies to Understand the Brain in Pain
Room: Lodge Ballroom

Speaker 2 of 5
Yves De Koninck, Université Laval, Quebec Mental Health Institute, Canada
Towards an All-Optical Functional Dissection of Pain Pathways

Monday, June 16 | 2:00PM - 3:30PM
Workshop: New Technologies to Understand the Brain in Pain
Room: Lodge Ballroom

Speaker 3 of 5
Katja Wiech, University of Oxford, UK

Monday, June 16 | 2:00PM - 3:30PM
Workshop: New Technologies to Understand the Brain in Pain
Room: Lodge Ballroom

Speaker 4 of 5
Jon-Kar Zubieta, University of Michigan, USA
Effects of tDCS on Endogenous Opioid Mechanisms

Monday, June 16 | 2:00PM - 3:30PM
Workshop: New Technologies to Understand the Brain in Pain
Room: Lodge Ballroom

Speaker 5 of 5
Tor D. Wager, University of Colorado at Boulder, USA
Towards fMRI-Based Biomarkers for Pain and Emotion

Monday, June 16 | 3:30PM - 4:00PM
Coffee Available
Room: Gallery


Monday, June 16 | 4:00PM - 6:00PM
New Technologies to Image the Human Brain Structure and Func
tion

Room: Lodge Ballroom

Speaker 1 of 5
* Robert C. Coghill, Cincinnati Children's Hopsital, USA

Monday, June 16 | 4:00PM - 6:00PM
New Technologies to Image the Human Brain Structure and Func
tion

Room: Lodge Ballroom

Speaker 2 of 5
Yves De Koninck, Université Laval, Quebec Mental Health Institute, Canada
Probing the Brain with Light

Monday, June 16 | 4:00PM - 6:00PM
New Technologies to Image the Human Brain Structure and Func
tion

Room: Lodge Ballroom

Speaker 3 of 5
Jing Wang, New York University School of Medicine, USA
Short Talk: Optogenetic Activation of Corticostriatal Circuitry Regulates Chronic Neuropathic Pain

Monday, June 16 | 4:00PM - 6:00PM
New Technologies to Image the Human Brain Structure and Func
tion

Room: Lodge Ballroom

Speaker 4 of 5
Katja Wiech, University of Oxford, UK
Imaging Pain

Monday, June 16 | 4:00PM - 6:00PM
New Technologies to Image the Human Brain Structure and Func
tion

Room: Lodge Ballroom

Speaker 5 of 5
Richard Hargreaves, Celgene, USA
Imaging to Optimize Analgesic Drug Discovery and Development

Monday, June 16 | 6:00PM - 7:00PM
Social Hour with Lite Bites
Room: Gallery/Lakeside Suite


Monday, June 16 | 7:00PM - 9:30PM
Poster Session 1
Room: Lodge Ballroom


Tuesday, June 17 | 7:30AM - 8:30AM
Breakfast
Room: Bighorn Room


Tuesday, June 17 | 8:30AM - 9:30AM
Keynote Address
Room: Lodge Ballroom

Speaker 1 of 2
* Frank Porreca, University of Arizona, USA

Tuesday, June 17 | 8:30AM - 9:30AM
Keynote Address
Room: Lodge Ballroom

Speaker 2 of 2
Howard L. Fields, University of California, San Francisco, USA
Mesolimbic Circuits: Where Pain and Pleasure Interact

Tuesday, June 17 | 9:30AM - 11:45AM
Dissecting Basic Brain Circuits Involved in Pain Behaviors
Room: Lodge Ballroom

Speaker 1 of 5
* A. Vania Apkarian, Northwestern University, USA

Tuesday, June 17 | 9:30AM - 11:45AM
Dissecting Basic Brain Circuits Involved in Pain Behaviors
Room: Lodge Ballroom

Speaker 2 of 5
Mark Tommerdahl, University of North Carolina, USA
Role of the Primary Somatosensory Cortex in Pain

Tuesday, June 17 | 9:30AM - 11:45AM
Dissecting Basic Brain Circuits Involved in Pain Behaviors
Room: Lodge Ballroom

Speaker 3 of 5
Robert C. Coghill, Cincinnati Children's Hopsital, USA
The Role of the Posterior Parietal Cortex in Pain

Tuesday, June 17 | 9:30AM - 11:45AM
Dissecting Basic Brain Circuits Involved in Pain Behaviors
Room: Lodge Ballroom

Speaker 4 of 5
Karen Davis, University of Toronto/Toronto Western Research Institute, Canada
Pain-Attention Brain Circuitry Phenotypes: Potential for Personalized Therapeutics?

Tuesday, June 17 | 9:30AM - 11:45AM
Dissecting Basic Brain Circuits Involved in Pain Behaviors
Room: Lodge Ballroom

Speaker 5 of 5
Neil Schwartz, Stanford University, USA
Short Talk: Decreased Motivation during Chronic Pain Requires Depression of the Nucleus Accumbens Indirect Pathway

Tuesday, June 17 | 10:00AM - 10:20AM
Coffee Break
Room: Gallery


Tuesday, June 17 | 11:45AM - 3:30PM
On Own for Lunch


Tuesday, June 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Lodge Ballroom


Tuesday, June 17 | 3:30PM - 4:00PM
Coffee Available
Room: Gallery


Tuesday, June 17 | 4:00PM - 6:15PM
Preclinical to Clinical Evaluation of Pain - Garnering a Bet
ter Approximation to the Human Condition

Room: Lodge Ballroom

Speaker 1 of 6
* Maria Fitzgerald, University College London, UK

Tuesday, June 17 | 4:00PM - 6:15PM
Preclinical to Clinical Evaluation of Pain - Garnering a Bet
ter Approximation to the Human Condition

Room: Lodge Ballroom

Speaker 2 of 6
Frank Porreca, University of Arizona, USA
Reward Circuits and Pain

Tuesday, June 17 | 4:00PM - 6:15PM
Preclinical to Clinical Evaluation of Pain - Garnering a Bet
ter Approximation to the Human Condition

Room: Lodge Ballroom

Speaker 3 of 6
Andrew Charles, University of California, Los Angeles, USA
Translational Models of the Migraine Brain State

Tuesday, June 17 | 4:00PM - 6:15PM
Preclinical to Clinical Evaluation of Pain - Garnering a Bet
ter Approximation to the Human Condition

Room: Lodge Ballroom

Speaker 4 of 6
Mirko Santello, University of Bern, Switzerland
Short Talk: Dysfunction of Dendritic Properties of Cortical Pyramidal Neurons in a Chronic Pain Model

Tuesday, June 17 | 4:00PM - 6:15PM
Preclinical to Clinical Evaluation of Pain - Garnering a Bet
ter Approximation to the Human Condition

Room: Lodge Ballroom

Speaker 5 of 6
Gary R. Strichartz, Harvard Medical School, Brigham and Women's Hospital, USA
Short Talk: Critical Role of the RVM in Chronic Pain after Thoracotomy

Tuesday, June 17 | 4:00PM - 6:15PM
Preclinical to Clinical Evaluation of Pain - Garnering a Bet
ter Approximation to the Human Condition

Room: Lodge Ballroom

Speaker 6 of 6
Chas Bountra, University of Oxford, UK
Working Together Pre-Competitively, Exploring Novel Epigenetic Proteins and Using Human Cells to Increase the Probability of Discovering New Analgesics

Tuesday, June 17 | 6:15PM - 7:15PM
Social Hour with Lite Bites
Room: Gallery/Lakeside Suite


Tuesday, June 17 | 7:15PM - 7:30PM
Transportation to Silverthorne


Tuesday, June 17 | 7:30PM - 9:00PM
Local Community Panel Discussion on Pain
Room: Silverthorne Pavilion
Drs. David Dodick and Frank Porreca, along with a local physician, Dr. Ross Dickstein, will present a community panel discussion on 'Pain' at the Silverthorne Community Center in Silverthorne CO. The discussion, which is targeted at a lay audience, is part of a Keystone Symposia outreach program to bring interesting science to our local community in Summit County. Bus transportation will be available for a limited number of conference participants who would like to attend the panel discussion.

Wednesday, June 18 | 7:30AM - 8:30AM
Breakfast
Room: Bighorn Room


Wednesday, June 18 | 8:30AM - 9:30AM
Keynote Address
Room: Lodge Ballroom

Speaker 1 of 2
* David W. Dodick, Mayo Clinic, USA

Wednesday, June 18 | 8:30AM - 9:30AM
Keynote Address
Room: Lodge Ballroom

Speaker 2 of 2
David Borsook, Children's Hospital, USA
Pain in Neurological Disease

Wednesday, June 18 | 9:30AM - 12:00PM
Pain in Neurological Disease States
Room: Lodge Ballroom

Speaker 1 of 6
* Giandomenico Iannetti, University College London, UK

Wednesday, June 18 | 9:30AM - 12:00PM
Pain in Neurological Disease States
Room: Lodge Ballroom

Speaker 2 of 6
Emeran Mayer, University of California, Los Angeles, USA
Brain Networks in Chronic Visceral Pain

Wednesday, June 18 | 9:30AM - 12:00PM
Pain in Neurological Disease States
Room: Lodge Ballroom

Speaker 3 of 6
Todd J. Schwedt, Mayo Clinic, USA
The Interictal Migraine Brain: Hypersensitive, Hypervigilant and Hyperactive

Wednesday, June 18 | 9:30AM - 12:00PM
Pain in Neurological Disease States
Room: Lodge Ballroom

Speaker 4 of 6
A. Vania Apkarian, Northwestern University, USA
The Neurological basis of Chronic Pain: Causes and Consequences

Wednesday, June 18 | 9:30AM - 12:00PM
Pain in Neurological Disease States
Room: Lodge Ballroom

Speaker 5 of 6
Vasco Galhardo, Faculdade de Medicina - Universidade do Porto, Portugal
Short Talk: Dopaminergic Reversal of Pain-Related Working Memory Deficits

Wednesday, June 18 | 9:30AM - 12:00PM
Pain in Neurological Disease States
Room: Lodge Ballroom

Speaker 6 of 6
Catherine D. Chong, Mayo Clinic Arizona, USA
Short Talk: Atypical Age-Related Cortical Thinning in Episodic Migraine

Wednesday, June 18 | 10:10AM - 10:30AM
Coffee Break
Room: Gallery


Wednesday, June 18 | 12:00PM - 3:30PM
On Own for Lunch


Wednesday, June 18 | 3:30PM - 4:00PM
Coffee Available
Room: Gallery


Wednesday, June 18 | 4:00PM - 6:00PM
Altered Processing of Pain
Room: Lodge Ballroom

Speaker 1 of 5
* Rami Burstein, Harvard Medical School, USA

Wednesday, June 18 | 4:00PM - 6:00PM
Altered Processing of Pain
Room: Lodge Ballroom

Speaker 2 of 5
Herta Flor, Medical Faculty Mannheim, Heidelberg University, Germany
Brain Circuits Involved in Phantom Limb Pain

Wednesday, June 18 | 4:00PM - 6:00PM
Altered Processing of Pain
Room: Lodge Ballroom

Speaker 3 of 5
Rami Burstein, Harvard Medical School, USA
Neurochemical Pathways that Modulate Thalamic Trigeminovascular Neurons

Wednesday, June 18 | 4:00PM - 6:00PM
Altered Processing of Pain
Room: Lodge Ballroom

Speaker 4 of 5
Jon Levine, University of California, San Francisco, USA
Mirror Mirror on the Wall, Who Is the Sexiest of Them All

Wednesday, June 18 | 4:00PM - 6:00PM
Altered Processing of Pain
Room: Lodge Ballroom

Speaker 5 of 5
Dustin Green, University of Texas Health Science Center at San Antonio, USA
Short Talk: Role of Endogenous TRPV1 Agonists in a Post-Burn Pain Model of Partial-Thickness Injury

Wednesday, June 18 | 6:00PM - 7:00PM
Social Hour with Lite Bites
Room: Gallery/Lakeside Suite


Wednesday, June 18 | 7:00PM - 9:30PM
Poster Session 2
Room: Lodge Ballroom


Thursday, June 19 | 7:30AM - 8:30AM
Breakfast
Room: Bighorn Room


Thursday, June 19 | 8:30AM - 9:30AM
Keynote Address
Room: Lodge Ballroom

Speaker 1 of 2
* David Borsook, Children's Hospital, USA

Thursday, June 19 | 8:30AM - 9:30AM
Keynote Address
Room: Lodge Ballroom

Speaker 2 of 2
Fabrizio Benedetti, University of Turin, Italy
Placebos and Drugs: What's the Difference?

Thursday, June 19 | 9:30AM - 11:15AM
The Brain and Self-Trickery in Pain and Analgesia
Room: Lodge Ballroom

Speaker 1 of 5
* Karen Davis, University of Toronto/Toronto Western Research Institute, Canada

Thursday, June 19 | 9:30AM - 11:15AM
The Brain and Self-Trickery in Pain and Analgesia
Room: Lodge Ballroom

Speaker 2 of 5
Jon-Kar Zubieta, University of Michigan, USA
Opioid Mechanisms, Pain Regulation and Placebo Analgesia

Thursday, June 19 | 9:30AM - 11:15AM
The Brain and Self-Trickery in Pain and Analgesia
Room: Lodge Ballroom

Speaker 3 of 5
Giandomenico Iannetti, University College London, UK
Pain and Perception

Thursday, June 19 | 9:30AM - 11:15AM
The Brain and Self-Trickery in Pain and Analgesia
Room: Lodge Ballroom

Speaker 4 of 5
Tor D. Wager, University of Colorado at Boulder, USA
Neuroimaging of the Generation and Regulation of Pain

Thursday, June 19 | 9:30AM - 11:15AM
The Brain and Self-Trickery in Pain and Analgesia
Room: Lodge Ballroom

Speaker 5 of 5
Richard D. Lane, University of Arizona, USA
Short Talk: Neural Correlates of Deficits in Pain-Related Affective Meaning Construction in Patients with Chronic Pain Disorder

Thursday, June 19 | 10:10AM - 10:30AM
Coffee Break
Room: Gallery


Thursday, June 19 | 11:15AM - 3:30PM
On Own for Lunch


Thursday, June 19 | 3:30PM - 4:00PM
Coffee Available
Room: Gallery


Thursday, June 19 | 4:00PM - 6:15PM
The Brain in Development
Room: Lodge Ballroom

Speaker 1 of 6
* Tor D. Wager, University of Colorado at Boulder, USA

Thursday, June 19 | 4:00PM - 6:15PM
The Brain in Development
Room: Lodge Ballroom

Speaker 2 of 6
Maria Fitzgerald, University College London, UK
Pain in the Young Brain Becomes Pain in the Older Brain

Thursday, June 19 | 4:00PM - 6:15PM
The Brain in Development
Room: Lodge Ballroom

Speaker 3 of 6
Stephen B. McMahon, King's College London, UK
Pain Genetics and Epigenetics

Thursday, June 19 | 4:00PM - 6:15PM
The Brain in Development
Room: Lodge Ballroom

Speaker 4 of 6
P. Ellen Grant, Boston Children's Hospital, USA
Human Brain Measures in Development

Thursday, June 19 | 4:00PM - 6:15PM
The Brain in Development
Room: Lodge Ballroom

Speaker 5 of 6
Lorenzo Fabrizi, University College London, UK
Short Talk: How Does Nociceptive Processing in the Human Infant Brain Compare with That in Adults?

Thursday, June 19 | 4:00PM - 6:15PM
The Brain in Development
Room: Lodge Ballroom

Speaker 6 of 6
Dusica Bajic, Boston Children's Hospital, USA
Short Talk: Rat Periaqueductal Gray Neurotransmitter Gene Expression with Development and Chronic Morphine

Thursday, June 19 | 6:15PM - 7:15PM
Social Hour with Lite Bites
Room: Gallery/Lakeside Suite


Thursday, June 19 | 7:00PM - 11:00PM
Entertainment
Room: Lodge Ballroom


Thursday, June 19 | 7:15PM - 11:00PM
Cash Bar
Room: Gallery/Lakeside Suite


Friday, June 20 | 10:25AM - 10:25AM
Departure


*Session Chair.