Web Desc
Obesity: A Multisystems Perspective
joint with Challenges and Opportunities in Diabetes Research and Treatment
Organizer(s): Roger D. Cone, Barbara Cannon and Lee M. Kaplan
Date: January 12 - 17, 2014
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
This meeting will cover the latest discoveries on the role of multiple organ systems in the process of energy homeostasis and obesity. In addition to the role of the central nervous system and white adipose tissue (WAT) depots, this meeting will examine the role of WAT development, brown fat, the microbiome, gut-brain signaling and circadian rhythms in the development of obesity. Bariatric surgery and the latest pharmaceutical approaches to obesity treatment will also be considered, as will the latest genetic approaches to both common and rare syndromic obesity. Joint sessions with the Keystone Symposia meeting on Challenges and Opportunities in Diabetes Research and Treatment will include “The Role of Brown Adipose Tissue in Thermogenesis and Glucose Uptake” and “Mechanisms Underlying the Efficacy of Bariatric Surgery.” This meeting will bring together a diverse array of leading scientists from the U.S., Europe and Japan to talk about breaking discoveries in a very broad array of physiological processes relevant to obesity and its treatment. The goal of the meeting will be to provide participants with an update on cutting-edge developments in the field, as well as with a broader perspective on the biology of obesity. The anticipated outcome is the development of new, and potentially interdisciplinary, research collaborations and directions.
Scholarship Deadline: October 4 2013
Discounted Abstract Deadline: October 4 2013
Abstract Deadline: October 29 2013
Discounted Registration Deadline: November 14 2013
Abstacts when book is in proofing process


We gratefully acknowledge additional support for this conference from:
AdipoGen InternationalResearch Diets, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Biochemical Society / Biochemical Journal
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-05
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 12 | 4:00PM - 8:00PM
Arrival and Registration
Room: British/Columbia Foyer


Monday, January 13 | 7:30AM - 8:30AM
Breakfast
Room: Pacific Ballroom


Monday, January 13 | 8:30AM - 9:30AM
Keynote Session (Joint)
Room: British/Columbia Ballroom

Speaker 1 of 1
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
An Increasing Web of Interactions in Diabetes and Obesity

Monday, January 13 | 9:30AM - 10:00AM
Coffee Break
Room: British/Columbia Foyer


Monday, January 13 | 10:00AM - 12:15PM
Development of Adipose Tissue
Room: Columbia Ballroom

Speaker 1 of 6
* Christian Wolfrum, ETH Zürich, Switzerland

Monday, January 13 | 10:00AM - 12:15PM
Development of Adipose Tissue
Room: Columbia Ballroom

Speaker 2 of 6
Jonathan M. Graff, University of Texas Southwestern Medical Center, USA
Adipose Stem Cells: Give Me a Pill Not a Treadmill

Monday, January 13 | 10:00AM - 12:15PM
Development of Adipose Tissue
Room: Columbia Ballroom

Speaker 3 of 6
Peter Arner, Karolinska Institutet, Sweden
Bone Marrow as a Source of Adipocytes in Adult Humans

Monday, January 13 | 10:00AM - 12:15PM
Development of Adipose Tissue
Room: Columbia Ballroom

Speaker 4 of 6
Matt Rodeheffer, Yale University, USA
Cellular Mechanisms of Adipogenesis in vivo

Monday, January 13 | 10:00AM - 12:15PM
Development of Adipose Tissue
Room: Columbia Ballroom

Speaker 5 of 6
David A. Guertin, University of Massachusetts Medical School, USA
Short Talk: New Insights into the Origins and Programming of Adipocyte Development

Monday, January 13 | 10:00AM - 12:15PM
Development of Adipose Tissue
Room: Columbia Ballroom

Speaker 6 of 6
Dwight J. Klemm, University of Colorado Denver Anschutz Medical Center, USA
Short Talk: De Novo Generation of Adipocytes from Bone Marrow in Human Adipose Tissue

Monday, January 13 | 10:00AM - 12:30PM
Metabolic Control in Liver
This session is from Diabetes
Room: British Ballroom

Speaker 1 of 6
* Masato Kasuga, National Center for Global Health and Medicine, Japan


Monday, January 13 | 10:00AM - 12:30PM
Metabolic Control in Liver
This session is from Diabetes
Room: British Ballroom

Speaker 2 of 6
Rebecca A. Haeusler, Columbia University, USA
Regulation of Metabolic Flux by FoxOs during the Fasting–Refeeding Transition


Monday, January 13 | 10:00AM - 12:30PM
Metabolic Control in Liver
This session is from Diabetes
Room: British Ballroom

Speaker 3 of 6
Morris J. Birnbaum, Pfizer Inc., USA
The Control of Hepatic Metabolism by Insulin


Monday, January 13 | 10:00AM - 12:30PM
Metabolic Control in Liver
This session is from Diabetes
Room: British Ballroom

Speaker 4 of 6
Kei Sakamoto, Nestlé Institute of Health Sciences, Switzerland
LKB1-SIK Signaling Pathway in the Control of Hepatic Gluconeogenesis


Monday, January 13 | 10:00AM - 12:30PM
Metabolic Control in Liver
This session is from Diabetes
Room: British Ballroom

Speaker 5 of 6
David J. Lloyd, Amgen, Inc., USA
Short Talk: Small Molecule Disruption of the GKRP-GK Interaction Accompanied with Glucose Lowering Efficacy


Monday, January 13 | 10:00AM - 12:30PM
Metabolic Control in Liver
This session is from Diabetes
Room: British Ballroom

Speaker 6 of 6
Hans-Ulrich Häring, Eberhard-Karls University Tübingen, Germany
Subphenotypes in Prediabetes: Role of Fatty Liver and Brain Insulin Resistance


Monday, January 13 | 12:15PM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Monday, January 13 | 12:15PM - 2:30PM
On Own for Lunch and Recreation


Monday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Obesity Drug Discovery
Room: Columbia Ballroom

Speaker 1 of 7
* Minmin Wang, Eli Lilly and Company, USA

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Obesity Drug Discovery
Room: Columbia Ballroom

Speaker 2 of 7
Lex H.T. Van der Ploeg, VDP LLC, USA
Melanocortin 4 Receptor Agonists for the Treatment of Obesity

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Obesity Drug Discovery
Room: Columbia Ballroom

Speaker 3 of 7
David Maggs, Fractyl Labs, USA
Endobarrier Therapy for Obesity and Diabetes

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Obesity Drug Discovery
Room: Columbia Ballroom

Speaker 4 of 7
Lotte Bjerre Knudsen, Novo Nordisk A/S, Denmark
Liraglutide Lowers Body Weight through CART, NPY and AgRP

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Obesity Drug Discovery
Room: Columbia Ballroom

Speaker 5 of 7
Yong Xu, Baylor College of Medicine, USA
Targeting Hypothalamic Steroid Receptor Co-Activator-1 to Treat Diet-Induced Obesity

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Obesity Drug Discovery
Room: Columbia Ballroom

Speaker 6 of 7
Zachary R. Patterson, Carleton University, Canada
Novel GOAT Inhibitor, CF801, Reduces Acylated Ghrelin and Body Weight in C57/BL6J Male Mice: A Potential Treatment for Obesity Related Disorders

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Obesity Drug Discovery
Room: Columbia Ballroom

Speaker 7 of 7
Susan Cellitti, Genomics Institute of the Novartis Research Foundation, USA
A Novel GLP-1-FGF21 Fusion Protein for the Treatment of Diabetes and Obesity

Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Insulin Sensitivity
This session is from Diabetes
Room: British Ballroom

Speaker 1 of 7
* Anna Krook, Karolinska Institutet, Sweden


Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Insulin Sensitivity
This session is from Diabetes
Room: British Ballroom

Speaker 2 of 7
Tine Hannibal, University of Copenhagen, Denmark
Investigating the Role of Plasmacytoid Dendritic Cells in Inflammation Associated with Diabetes


Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Insulin Sensitivity
This session is from Diabetes
Room: British Ballroom

Speaker 3 of 7
Jan Mauer, Max Planck Institute for Neurological Research, Germany
Novel Aspects of Macrophage IL-6-Signaling in Obesity-Associated Inflammation


Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Insulin Sensitivity
This session is from Diabetes
Room: British Ballroom

Speaker 4 of 7
Tadasuke Komori, Wakayama Medical University, Japan
Oncostatin M Protects against Obesity and Related Metabolic Disorders in Mice


Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Insulin Sensitivity
This session is from Diabetes
Room: British Ballroom

Speaker 5 of 7
Aurele Besse-Patin, Montreal Neurological Institute, Canada
Loss of Pgc-1alpha Expression in Aging Mouse Muscle Potentiates Glucose Intolerance and Systemic Inflammation


Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Insulin Sensitivity
This session is from Diabetes
Room: British Ballroom

Speaker 6 of 7
Yan-Shan Dai, Central South University, China
NFATc3 Is Required for Pancreatic beta-Cell Function and Adipose Tissue Inflammation


Monday, January 13 | 2:30PM - 4:30PM
Workshop 1: Inflammation and Insulin Sensitivity
This session is from Diabetes
Room: British Ballroom

Speaker 7 of 7
Darren C. Henstridge, Baker IDI Heart and Diabetes Institute, Australia
HSP72 Prevents Peripheral Tissue Lipotoxicity and Preserves Insulin Sensitivity by Increasing Oxidative Metabolism in Skeletal Muscle


Monday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Monday, January 13 | 5:00PM - 7:15PM
Role of Brown Adipose Tissue in Thermogenesis and Glucose Up
take (Joint)

Room: British/Columbia Ballroom

Speaker 1 of 6
* Jan Nedergaard, Stockholm University, Sweden

Monday, January 13 | 5:00PM - 7:15PM
Role of Brown Adipose Tissue in Thermogenesis and Glucose Up
take (Joint)

Room: British/Columbia Ballroom

Speaker 2 of 6
* Alexander S. Banks, Harvard Medical School, USA

Monday, January 13 | 5:00PM - 7:15PM
Role of Brown Adipose Tissue in Thermogenesis and Glucose Up
take (Joint)

Room: British/Columbia Ballroom

Speaker 3 of 6
Barbara Cannon, Stockholm University, Sweden
Brown adipose tissue and thermogenesis

Monday, January 13 | 5:00PM - 7:15PM
Role of Brown Adipose Tissue in Thermogenesis and Glucose Up
take (Joint)

Room: British/Columbia Ballroom

Speaker 4 of 6
Joerg Heeren, University Medical Center Hamburg-Eppendorf, Germany
Brown Adipose Tissue and a Potential Role in Resolution of the Metabolic Syndrome

Monday, January 13 | 5:00PM - 7:15PM
Role of Brown Adipose Tissue in Thermogenesis and Glucose Up
take (Joint)

Room: British/Columbia Ballroom

Speaker 5 of 6
Masayuki Saito, Tenshi College, Japan
Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fatness in Humans

Monday, January 13 | 5:00PM - 7:15PM
Role of Brown Adipose Tissue in Thermogenesis and Glucose Up
take (Joint)

Room: British/Columbia Ballroom

Speaker 6 of 6
Antonio J. Vidal-Puig, University of Cambridge, UK
BMP8b and Thermogenesis

Monday, January 13 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Monday, January 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Tuesday, January 14 | 7:30AM - 8:30AM
Breakfast
Room: Pacific Ballroom


Tuesday, January 14 | 8:00AM - 8:30AM
Poster Setup
Room: Pacific Ballroom


Tuesday, January 14 | 8:30AM - 7:00PM
Poster Viewing
Room: Pacific Ballroom


Tuesday, January 14 | 8:30AM - 11:45AM
Mechanisms Underlying the Efficacy of Bariatric Surgery (Joi
nt)

Room: British/Columbia Ballroom

Speaker 1 of 8
* C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

Tuesday, January 14 | 8:30AM - 11:45AM
Mechanisms Underlying the Efficacy of Bariatric Surgery (Joi
nt)

Room: British/Columbia Ballroom

Speaker 2 of 8
* Laurent Gautron, University of Texas Southwestern Medical Center, USA

Tuesday, January 14 | 8:30AM - 11:45AM
Mechanisms Underlying the Efficacy of Bariatric Surgery (Joi
nt)

Room: British/Columbia Ballroom

Speaker 3 of 8
Lee M. Kaplan, Massachusetts General Hospital, USA
Molecular Mechanisms of Response to Roux-en-Y Gastric Bypass

Tuesday, January 14 | 8:30AM - 11:45AM
Mechanisms Underlying the Efficacy of Bariatric Surgery (Joi
nt)

Room: British/Columbia Ballroom

Speaker 4 of 8
Blandine Laferrère, St. Luke's-Roosevelt, Columbia University, USA
Mechanism of Diabetes Remission after Gastric Bypass Surgery: Not Just Weight Loss

Tuesday, January 14 | 8:30AM - 11:45AM
Mechanisms Underlying the Efficacy of Bariatric Surgery (Joi
nt)

Room: British/Columbia Ballroom

Speaker 5 of 8
Carel Le Roux, University College Dublin, Ireland
Gastro Intestinal Regulation of Appetitive Drives

Tuesday, January 14 | 8:30AM - 11:45AM
Mechanisms Underlying the Efficacy of Bariatric Surgery (Joi
nt)

Room: British/Columbia Ballroom

Speaker 6 of 8
Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA
Neural Mechanisms of Gastric Bypass

Tuesday, January 14 | 8:30AM - 11:45AM
Mechanisms Underlying the Efficacy of Bariatric Surgery (Joi
nt)

Room: British/Columbia Ballroom

Speaker 7 of 8
Nicholas Stylopoulos, Harvard Medical School and Boston Children's Hospital, USA
Short Talk: Bypassing Diabetes by Reprogramming Intestinal Metabolism

Tuesday, January 14 | 8:30AM - 11:45AM
Mechanisms Underlying the Efficacy of Bariatric Surgery (Joi
nt)

Room: British/Columbia Ballroom

Speaker 8 of 8
Thomas Alexander Lutz, University of Zürich, Switzerland
Short Talk: GLP-1 Contributes to Improved Vascular Reactivity after Roux-en-Y Gastric Bypass Surgery (RYGB)

Tuesday, January 14 | 9:50AM - 10:10AM
Coffee Break
Room: British/Columbia Foyer


Tuesday, January 14 | 11:45AM - 12:30PM
Lunch
Room: Pacific Ballroom


Tuesday, January 14 | 12:00PM - 2:30PM
Poster Session 2
Room: Pacific Ballroom


Tuesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Hypothalamic Development and Maternal Effects
Room: Columbia Ballroom

Speaker 1 of 5
Richard B. Simerly, Vanderbilt University, USA
Hypothalamic Development

Tuesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Hypothalamic Development and Maternal Effects
Room: Columbia Ballroom

Speaker 2 of 5
Kevin L. Grove, Novo Nordisk, USA
Effects of Maternal Overnutrition

Tuesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Hypothalamic Development and Maternal Effects
Room: Columbia Ballroom

Speaker 3 of 5
Lori M. Zeltser, Columbia University, USA
Early Intervention in a Mouse Model of Childhood Obesity


Tuesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Hypothalamic Development and Maternal Effects
Room: Columbia Ballroom

Speaker 4 of 5
* William F. Colmers, University of Alberta, Canada
Talk Title Unknown

Tuesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Hypothalamic Development and Maternal Effects
Room: Columbia Ballroom

Speaker 5 of 5
Sebastien G. Bouret, Inserm U1172, France
Molecular Mechanisms Involved in Hypothalamic Development

Tuesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Advances in the Diabetes Drug Pipeline
This session is from Diabetes
Room: British Ballroom

Speaker 1 of 7
Avirup Bose, Novartis Institutes for Biomedical Research Inc., USA
FGF21 Pharmacology: Implications for T2D and Beyond?


Tuesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Advances in the Diabetes Drug Pipeline
This session is from Diabetes
Room: British Ballroom

Speaker 2 of 7
Philip J. Larsen, Bayer Pharmaceuticals, Germany
Diabetes Therapy of Tomorrow: Beyond Glycemic Control


Tuesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Advances in the Diabetes Drug Pipeline
This session is from Diabetes
Room: British Ballroom

Speaker 3 of 7
Anish Konkar, MedImmune, Inc., USA
Leveraging Gut Peptides for the Treatment of Type 2 Diabetes


Tuesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Advances in the Diabetes Drug Pipeline
This session is from Diabetes
Room: British Ballroom

Speaker 4 of 7
* Cristina M. Rondinone, Cellarity Inc., USA
Biologics: The Future of Cardiometabolic Medicines?


Tuesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Advances in the Diabetes Drug Pipeline
This session is from Diabetes
Room: British Ballroom

Speaker 5 of 7
Alessandro Pocai, Janssen, Pharmaceutical Companies of Johnson & Johnson, USA
Glucagon Agonism to Treat Diabetes


Tuesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Advances in the Diabetes Drug Pipeline
This session is from Diabetes
Room: British Ballroom

Speaker 6 of 7
Yoshiyuki Tsujihata, Takeda Pharmaceutical Company, Ltd., Japan
Efficacy of Mono and Combination Therapy with GPR40/FFAR1 Agonist Fasiglifam in Animal Models Suggest Potential New Treatment for Type 2 Diabetes


Tuesday, January 14 | 2:30PM - 4:30PM
Workshop 2: Advances in the Diabetes Drug Pipeline
This session is from Diabetes
Room: British Ballroom

Speaker 7 of 7
* Bei B. Zhang, Pfizer Inc., USA
Challenges and Opportunities in Diabetes Drug Discovery


Tuesday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Tuesday, January 14 | 5:00PM - 6:45PM
Role of the Gut Microbiota in Obesity and Metabolic Disorder
s

Room: Columbia Ballroom

Speaker 1 of 4
* Helen Cox, King's College London, UK

Tuesday, January 14 | 5:00PM - 6:45PM
Role of the Gut Microbiota in Obesity and Metabolic Disorder
s

Room: Columbia Ballroom

Speaker 2 of 4
Frank J. Gonzalez, National Institutes of Health, USA
Microbiome and Intestinal Farnesoid X Receptor in the Control of Obesity

Tuesday, January 14 | 5:00PM - 6:45PM
Role of the Gut Microbiota in Obesity and Metabolic Disorder
s

Room: Columbia Ballroom

Speaker 3 of 4
Martin J. Blaser, New York University School of Medicine, USA
Effects of Early Life Antibiotics on Developmental Phenotypes

Tuesday, January 14 | 5:00PM - 6:45PM
Role of the Gut Microbiota in Obesity and Metabolic Disorder
s

Room: Columbia Ballroom

Speaker 4 of 4
Patrice D. Cani, Université Catholique de Louvain, Belgium
Cross-Talks between Host Intestinal Epithelial Cells and Gut Microbes Controls Energy Homeostasis

Tuesday, January 14 | 5:00PM - 6:45PM
Diabetes and Neurodegenerative Disorders
This session is from Diabetes
Room: British Ballroom

Speaker 1 of 3
* Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
IRS Signaling Balances Metabolic Homeostasis and Neurodegeneration


Tuesday, January 14 | 5:00PM - 6:45PM
Diabetes and Neurodegenerative Disorders
This session is from Diabetes
Room: British Ballroom

Speaker 2 of 3
Linda Partridge, Max Planck Institute for Biology of Ageing, Germany
Nutrient-Sensing Pathways and Aging


Tuesday, January 14 | 5:00PM - 6:45PM
Diabetes and Neurodegenerative Disorders
This session is from Diabetes
Room: British Ballroom

Speaker 3 of 3
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
The Dual Function of Autophagy in Aging and Age-Related Disorders


Tuesday, January 14 | 6:45PM - 6:45PM
On Own for Dinner


Wednesday, January 15 | 7:30AM - 8:30AM
Breakfast
Room: Pacific Ballroom


Wednesday, January 15 | 8:30AM - 11:45AM
Genetics of Obesity and Metabolic Traits
Room: Columbia Ballroom

Speaker 1 of 7
* Elizabeth K. Speliotes, University of Michigan, USA

Wednesday, January 15 | 8:30AM - 11:45AM
Genetics of Obesity and Metabolic Traits
Room: Columbia Ballroom

Speaker 2 of 7
Struan F. A. Grant, Children’s Hospital of Philadelphia Research Institute, USA
Genetics of Common Paediatric Obesity

Wednesday, January 15 | 8:30AM - 11:45AM
Genetics of Obesity and Metabolic Traits
Room: Columbia Ballroom

Speaker 3 of 7
Cristen J. Willer, University of Michigan, USA
Genetic Architecture of Obesity: Lessons Learned from Lipids

Wednesday, January 15 | 8:30AM - 11:45AM
Genetics of Obesity and Metabolic Traits
Room: Columbia Ballroom

Speaker 4 of 7
Sadaf Farooqi, University of Cambridge, UK
Genetic Basis of Severe Obesity

Wednesday, January 15 | 8:30AM - 11:45AM
Genetics of Obesity and Metabolic Traits
Room: Columbia Ballroom

Speaker 5 of 7
Abhimanyu Garg, University of Texas Southwestern Medical Center, USA
Genetic Basis of Lipodystrophies

Wednesday, January 15 | 8:30AM - 11:45AM
Genetics of Obesity and Metabolic Traits
Room: Columbia Ballroom

Speaker 6 of 7
Marcelo Nobrega, University of Chicago, USA
Short Talk: Obesity-Associated Variants within FTO Form Long-Range Functional Connections with IRX3

Wednesday, January 15 | 8:30AM - 11:45AM
Genetics of Obesity and Metabolic Traits
Room: Columbia Ballroom

Speaker 7 of 7
Christopher Lelliott, Wellcome Trust Sanger Institute, UK
Short Talk: Discovery of Novel Genes Relevant for Metabolic Homeostasis by the Sanger Mouse Genetics Project

Wednesday, January 15 | 8:30AM - 11:30AM
Nutrigenomics
This session is from Diabetes
Room: British Ballroom

Speaker 1 of 7
* Simeon Taylor, University of Maryland School of Medicine, USA


Wednesday, January 15 | 8:30AM - 11:30AM
Nutrigenomics
This session is from Diabetes
Room: British Ballroom

Speaker 2 of 7
Christopher B. Newgard, Duke University Medical Center, USA
Intermediary Metabolism and Insulin Resistance


Wednesday, January 15 | 8:30AM - 11:30AM
Nutrigenomics
This session is from Diabetes
Room: British Ballroom

Speaker 3 of 7
Murielle M. Veniant, Amgen Inc., USA
FGF21, a Potential Therapeutic for Type 2 Diabetes


Wednesday, January 15 | 8:30AM - 11:30AM
Nutrigenomics
This session is from Diabetes
Room: British Ballroom

Speaker 4 of 7
Feifan Guo, Institute for Nutritional Sciences, China
Branched Chain Amino Acids and Metabolic Signaling


Wednesday, January 15 | 8:30AM - 11:30AM
Nutrigenomics
This session is from Diabetes
Room: British Ballroom

Speaker 5 of 7
Wataru Ogawa, Kobe University, Japan
Novel Variants of PGC1alpha and Muscle Energy Efficiency


Wednesday, January 15 | 8:30AM - 11:30AM
Nutrigenomics
This session is from Diabetes
Room: British Ballroom

Speaker 6 of 7
Alexander S. Banks, Harvard Medical School, USA
Short Talk: Both Erk and Cdk5 Kinases Control the Diabetogenic Actions of PPARgamma


Wednesday, January 15 | 8:30AM - 11:30AM
Nutrigenomics
This session is from Diabetes
Room: British Ballroom

Speaker 7 of 7
Christian Bjorbaek, Beth Israel Deaconess Medical Center, USA
Short Talk: Hypothalamic AgRP Neurons and the Central Melanocortin System are Mediators of Leptin’s Anti-Diabetic Actions


Wednesday, January 15 | 9:50AM - 10:10AM
Coffee Break
Room: British/Columbia Foyer


Wednesday, January 15 | 11:45AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Wednesday, January 15 | 11:45AM - 5:00PM
On Own for Lunch and Recreation


Wednesday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Wednesday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Wednesday, January 15 | 5:00PM - 7:00PM
CNS Control of Energy Homeostasis
Room: Columbia Ballroom

Speaker 1 of 5
* Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany

Wednesday, January 15 | 5:00PM - 7:00PM
CNS Control of Energy Homeostasis
Room: Columbia Ballroom

Speaker 2 of 5
Scott M. Sternson, HHMI/Janelia Research Campus, USA
Neural Circuits that Control Feeding Behavior

Wednesday, January 15 | 5:00PM - 7:00PM
CNS Control of Energy Homeostasis
Room: Columbia Ballroom

Speaker 3 of 5
Roger D. Cone, University of Michigan, USA
Novel Allosteric Modulators and Signaling Modalities of the Melanocortin-4 Receptor

Wednesday, January 15 | 5:00PM - 7:00PM
CNS Control of Energy Homeostasis
Room: Columbia Ballroom

Speaker 4 of 5
Michael Rosenbaum, Columbia University Medical College, USA
Leptin Depletion and Repletion

Wednesday, January 15 | 5:00PM - 7:00PM
CNS Control of Energy Homeostasis
Room: Columbia Ballroom

Speaker 5 of 5
Peter K. Jackson, Stanford University, USA
Short Talk: Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndromepathway to Signal in Neuronal Primary Cilia

Wednesday, January 15 | 5:00PM - 7:00PM
Insulin Sensitivity in the CV System
This session is from Diabetes
Room: British Ballroom

Speaker 1 of 5
* Juleen R. Zierath, Karolinska Institutet, Sweden


Wednesday, January 15 | 5:00PM - 7:00PM
Insulin Sensitivity in the CV System
This session is from Diabetes
Room: British Ballroom

Speaker 2 of 5
Alan R. Tall, Columbia University, USA
Diabetes and Obesity Promote Myelopoiesis and Atherogenesis


Wednesday, January 15 | 5:00PM - 7:00PM
Insulin Sensitivity in the CV System
This session is from Diabetes
Room: British Ballroom

Speaker 3 of 5
E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Myocardial Insulin Signaling, Hyperinsulinemia and Heart Failure


Wednesday, January 15 | 5:00PM - 7:00PM
Insulin Sensitivity in the CV System
This session is from Diabetes
Room: British Ballroom

Speaker 4 of 5
Sekar Kathiresan, Verve Therapeutics, USA
Diabetes and Cardiovascular Disease: Is there a Causal Link in Humans?


Wednesday, January 15 | 5:00PM - 7:00PM
Insulin Sensitivity in the CV System
This session is from Diabetes
Room: British Ballroom

Speaker 5 of 5
In-Kyu Lee, Kyungpook National University Hospital, South Korea
Short Talk: The Role of PDK4 in Vascular Calcification


Wednesday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Wednesday, January 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Pacific Ballroom


Thursday, January 16 | 7:30AM - 8:30AM
Breakfast
Room: Pacific Ballroom


Thursday, January 16 | 8:30AM - 11:45AM
Circadian Rhythms, Obesity and Metabolic Disorders
Room: Columbia Ballroom

Speaker 1 of 6
Joseph T. Bass, Northwestern University, USA
Circadian Integration of Mitochondrial Oxidative Function and Behavior

Thursday, January 16 | 8:30AM - 11:45AM
Circadian Rhythms, Obesity and Metabolic Disorders
Room: Columbia Ballroom

Speaker 2 of 6
Eve Van Cauter, University of Chicago, USA
Sleep Disturbances and Obesity

Thursday, January 16 | 8:30AM - 11:45AM
Circadian Rhythms, Obesity and Metabolic Disorders
Room: Columbia Ballroom

Speaker 3 of 6
* Satchidananda Panda, The Salk Institute for Biological Studies, USA
Rhythmic Feeding and Fasting Prevents Metabolic Diseases in Mice

Thursday, January 16 | 8:30AM - 11:45AM
Circadian Rhythms, Obesity and Metabolic Disorders
Room: Columbia Ballroom

Speaker 4 of 6
Joseph S. Takahashi, HHMI/University of Texas Southwestern Medical Center, USA
Molecular Mechanisms of the Mammalian Circadian Clock

Thursday, January 16 | 8:30AM - 11:45AM
Circadian Rhythms, Obesity and Metabolic Disorders
Room: Columbia Ballroom

Speaker 5 of 6
Zach Gerhart-Hines, University of Copenhagen, Denmark
Short Talk: The Nuclear Receptor Rev-erb? Controls Circadian Thermogenic Plasticity

Thursday, January 16 | 8:30AM - 11:45AM
Circadian Rhythms, Obesity and Metabolic Disorders
Room: Columbia Ballroom

Speaker 6 of 6
Rosa van den Berg, Leiden University Medical Center, Netherlands
Short Talk: Circadian Rhythm Modulates Body Fat Mass through Regulation of Brown Adipose Tissue Function

Thursday, January 16 | 8:30AM - 11:30AM
Diabetes and Cancer
This session is from Diabetes
Room: British Ballroom

Speaker 1 of 5
* Lily Q. Dong, University of Texas Health Science Center, USA


Thursday, January 16 | 8:30AM - 11:30AM
Diabetes and Cancer
This session is from Diabetes
Room: British Ballroom

Speaker 2 of 5
Derek Leroith, Mount Sinai School of Medicine, USA
Diabetes and Cancer: The Role of Insulin and IGFs


Thursday, January 16 | 8:30AM - 11:30AM
Diabetes and Cancer
This session is from Diabetes
Room: British Ballroom

Speaker 3 of 5
Timothy E. McGraw, Weill Medical College of Cornell University, USA
Cancer Metabolism


Thursday, January 16 | 8:30AM - 11:30AM
Diabetes and Cancer
This session is from Diabetes
Room: British Ballroom

Speaker 4 of 5
Kathryn E. Wellen, University of Pennsylvania, USA
Metabolic Reprogramming in Cancer Cells: Links to the Epigenome


Thursday, January 16 | 8:30AM - 11:30AM
Diabetes and Cancer
This session is from Diabetes
Room: British Ballroom

Speaker 5 of 5
Li Qiang, Columbia University Medical Center, USA
Short Talk: Deficiency of Deleted in Breast Cancer 1 Increases Risks for Metabolic Disorders through Activation of Stearoyl-Coenzyme A Desaturase 1


Thursday, January 16 | 9:50AM - 10:10AM
Coffee Break
Room: British/Columbia Foyer


Thursday, January 16 | 11:45AM - 12:30PM
Joint Workshop: NIH Funding Opportunities through NIDDK
Room: Columbia Ballroom

Speaker 1 of 2
Carol Renfrew Haft, NIDDK, National Institutes of Health, USA

Thursday, January 16 | 11:45AM - 12:30PM
Joint Workshop: NIH Funding Opportunities through NIDDK
Room: Columbia Ballroom

Speaker 2 of 2
Aaron Pawlyk, Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA

Thursday, January 16 | 12:30PM - 2:30PM
On Own for Lunch and Recreation


Thursday, January 16 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Results
Room: Columbia Ballroom

Speaker 1 of 9
* Lora K. Heisler, Rowett Institute, University of Aberdeen, UK

Thursday, January 16 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Results
Room: Columbia Ballroom

Speaker 2 of 9
Brian Finan, Novo Nordisk, USA
Molecular Cold Mimicry via TRPM8 Modulation Amplifies Thermogenesis by Influencing the Adrenergic Axis

Thursday, January 16 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Results
Room: Columbia Ballroom

Speaker 3 of 9
Diego V. Bohórquez, Duke University Medical Center, USA
A Gut-Brain Neurocircuit Unveiled

Thursday, January 16 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Results
Room: Columbia Ballroom

Speaker 4 of 9
Jayne F. Martin Carli, Columbia University Medical Center, USA
Functional Analysis of Potential Modifiers of Leptin Production Identified by GWAS

Thursday, January 16 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Results
Room: Columbia Ballroom

Speaker 5 of 9
Chen Liu, University of Texas Southwestern Medical Center, USA
A Paradoxical Orexigenic 5HT2CR Circuit in Forebrain Sim1 Neurons

Thursday, January 16 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Results
Room: Columbia Ballroom

Speaker 6 of 9
Joseph H. Nadeau, Maine Medical Center Research Institute, USA
Fractal Genetics, Gene Interactions and Systems Properties of Diet Induced Metabolic Conditions

Thursday, January 16 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Results
Room: Columbia Ballroom

Speaker 7 of 9
Maja Storm Engelstoft, Kallyope, USA
Identical Nutrient Metabolite Sensors Stimulate GLP-1 Release and Inhibit Ghrelin Release through Differential, Cell-Specific G Protein Coupling

Thursday, January 16 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Results
Room: Columbia Ballroom

Speaker 8 of 9
Eugenia Morselli, University of Texas Southwestern Medical Center, USA
Hypothalamic PGC-1alpha Protects against High Fat Diet Exposure by Regulating ER alpha

Thursday, January 16 | 2:30PM - 4:30PM
Workshop 3: Late Breaking Results
Room: Columbia Ballroom

Speaker 9 of 9
Arian F. Baquero, Novo Nordisk Inc., USA
ATP-Sensitive Potassium Channels (KATP) Are Essential for the Switch in Leptin Signaling to its Inhibitory Actions on NPY/AgRP Neurons during Development

Thursday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Thursday, January 16 | 5:00PM - 7:15PM
All Kinds of -kines
Room: Columbia Ballroom

Speaker 1 of 6
* Sheila Collins, Vanderbilt University Medical Center, USA

Thursday, January 16 | 5:00PM - 7:15PM
All Kinds of -kines
Room: Columbia Ballroom

Speaker 2 of 6
Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
FGF21: From Feast to Famine to Pharmacology

Thursday, January 16 | 5:00PM - 7:15PM
All Kinds of -kines
Room: Columbia Ballroom

Speaker 3 of 6
Ruth E. Gimeno, Eli Lilly and Company, USA
Secreted Proteins as Therapeutic Targets for Metabolic Disorders

Thursday, January 16 | 5:00PM - 7:15PM
All Kinds of -kines
Room: Columbia Ballroom

Speaker 4 of 6
Jaemyoung Suh, Korea Advanced Institute of Science & Technology, South Korea
New Roles for FGF1 in Metabolic Homeostasis and Insulin Sensitization

Thursday, January 16 | 5:00PM - 7:15PM
All Kinds of -kines
Room: Columbia Ballroom

Speaker 5 of 6
Rajesh R. Rao, Genomics Institute of Novartis Research Foundation, USA
Short Talk: Identification of a Novel PGC-1alpha4-Dependent Myokine that Regulates Adipose Tissue Thermogenesis, Energy Homeostasis and Inflammation

Thursday, January 16 | 5:00PM - 7:15PM
All Kinds of -kines
Room: Columbia Ballroom

Speaker 6 of 6
Nicholas Douris, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Short Talk: The Sympathetic Nervous System Mediates Systemic Adaptation to the Ketogenic Diet

Thursday, January 16 | 5:00PM - 7:00PM
Approaches to Beta Cell Failure in Type 2 Diabetes
This session is from Diabetes
Room: British Ballroom

Speaker 1 of 4
Susumu Seino, Kobe University Graduate School of Medicine, Japan
Cell Signaling in Insulin Secretion: Novel Mechanisms of cAMP Action


Thursday, January 16 | 5:00PM - 7:00PM
Approaches to Beta Cell Failure in Type 2 Diabetes
This session is from Diabetes
Room: British Ballroom

Speaker 2 of 4
Domenico Accili, Columbia University, USA
beta-Cell Dedifferentiation and beta-Cell Failure


Thursday, January 16 | 5:00PM - 7:00PM
Approaches to Beta Cell Failure in Type 2 Diabetes
This session is from Diabetes
Room: British Ballroom

Speaker 3 of 4
* Andrew F. Stewart, Mount Sinai School of Medicine, USA
Beta Cell Expansion Strategies


Thursday, January 16 | 5:00PM - 7:00PM
Approaches to Beta Cell Failure in Type 2 Diabetes
This session is from Diabetes
Room: British Ballroom

Speaker 4 of 4
Tsai-Hsiu Tess Lu, Max-Planck Institute of Immunobiology and Epigenetics, Germany
Short Talk: PRC2 Stabilizes Functional Beta-Cell Transcriptional Program and Prevents Terminal Dedifferentiation


Thursday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Thursday, January 16 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom


Thursday, January 16 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Friday, January 17 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.