Web Desc
Pathogenesis of Respiratory Viruses
joint with Innate Immunity to Viral Infections
Organizer(s): Adolfo García-Sastre and Peter J.M. Openshaw
Date: January 19 - 24, 2014
Location: Keystone Resort, Keystone, CO, USA
Sponsored by AstraZeneca
Summary of Meeting:
Respiratory viruses are a major cause of infectious disease and death in humans. The Keystone Symposia meeting on 'Pathogenesis of Respiratory Viruses' will discuss some of the latest advances in our understanding of the biology and pathogenesis of this group of viruses, including major human pathogens such as influenza viruses, respiratory syncytial virus, parainfluenza virus, rhinoviruses, coronaviruses and adenoviruses. There will be a special emphasis on influenza and respiratory syncytial virus. This meeting will bring together experts in virology, viral pathogenesis and viral immunity to discuss factors contributing to viral replication, tropism, disease and immunity in the respiratory tract. Opportunities for synergistic interactions will be significantly enhanced by the concurrent meeting on 'Innate Immunity to Viral Infections,' resulting in a more integrated view of viral disease and immunity.
Scholarship Deadline: October 9 2013
Discounted Abstract Deadline: October 9 2013
Abstract Deadline: October 31 2013
Discounted Registration Deadline: November 19 2013
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZeneca
We gratefully acknowledge additional support for this conference from:
MedImmune
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Institutes for BioMedical Research
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
EMBO (European Molecular Biology Organization)
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI110083-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Monday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud/Shavano


Monday, January 20 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 1 of 3
* Adolfo García-Sastre, Mount Sinai School of Medicine, USA

Monday, January 20 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 2 of 3
* Caetano Reis e Sousa, Francis Crick Institute, UK
RLRs in Immunity to Viruses

Monday, January 20 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 3 of 3
Peter M. Palese, Icahn School of Medicine at Mount Sinai, USA
Why Do Influenza Viruses Undergo Antigenic Drift and Shift and What Can We Do About It?

Monday, January 20 | 10:00AM - 10:20AM
Coffee Break
Room: Longs Peak Foyer


Monday, January 20 | 10:20AM - 12:00PM
Viral Entry and Replication
Room: Quandary Peak
Glycoprotein structure, viral entry and genome replication.
Speaker 1 of 4
* Yoshihiro Kawaoka, University of Wisconsin / University of Tokyo, USA

Monday, January 20 | 10:20AM - 12:00PM
Viral Entry and Replication
Room: Quandary Peak
Glycoprotein structure, viral entry and genome replication.
Speaker 2 of 4
Ian A. Wilson, The Scripps Research Institute, USA
Structural Basis of Influenza HA Function and Neutralization

Monday, January 20 | 10:20AM - 12:00PM
Viral Entry and Replication
Room: Quandary Peak
Glycoprotein structure, viral entry and genome replication.
Speaker 3 of 4
James E. Crowe, Jr., Vanderbilt University Medical Center, USA
Host-Virus Interactions during RSV Infection

Monday, January 20 | 10:20AM - 12:00PM
Viral Entry and Replication
Room: Quandary Peak
Glycoprotein structure, viral entry and genome replication.
Speaker 4 of 4
Robert A. Lamb, Northwestern University, USA
The Mechanism of Entry into Cells by Membrane Fusion for Respiratory Negative Strand Viruses

Monday, January 20 | 10:20AM - 12:00PM
Antiviral Strategies Across Taxa
This session is from Innate Immunity
Room: Longs/Grays Peaks
Virus defense strategies in bacteria, plants and invertebrates, CRISPR RNAs, RNAi, death.
Speaker 1 of 4
* Sara R. Cherry, University of Pennsylvania, USA


Monday, January 20 | 10:20AM - 12:00PM
Antiviral Strategies Across Taxa
This session is from Innate Immunity
Room: Longs/Grays Peaks
Virus defense strategies in bacteria, plants and invertebrates, CRISPR RNAs, RNAi, death.
Speaker 2 of 4
Luciano A. Marraffini, Rockefeller University, USA
Tolerance during CRISPR-Cas Immunity: Domesticating the Virus


Monday, January 20 | 10:20AM - 12:00PM
Antiviral Strategies Across Taxa
This session is from Innate Immunity
Room: Longs/Grays Peaks
Virus defense strategies in bacteria, plants and invertebrates, CRISPR RNAs, RNAi, death.
Speaker 3 of 4
Jean-Luc Imler, Institut de Biologie Moléculaire et Cellulaire, France
Sensing and Signaling Viral Infection in Drosophila


Monday, January 20 | 10:20AM - 12:00PM
Antiviral Strategies Across Taxa
This session is from Innate Immunity
Room: Longs/Grays Peaks
Virus defense strategies in bacteria, plants and invertebrates, CRISPR RNAs, RNAi, death.
Speaker 4 of 4
Shou-Wei Ding, University of California, Riverside, USA
RNAi as an Antiviral Strategy across Species, including Vertebrates


Monday, January 20 | 12:00PM - 1:00PM
Poster Setup
Room: Crestone/Red Cloud/Shavano


Monday, January 20 | 12:00PM - 2:30PM
On Own for Lunch and Recreation


Monday, January 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone/Red Cloud/Shavano


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
Room: Quandary Peak

Speaker 1 of 10
* James E. Crowe, Jr., Vanderbilt University Medical Center, USA

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
Room: Quandary Peak

Speaker 2 of 10
* Cecilia Johansson, Imperial College London, UK

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
Room: Quandary Peak

Speaker 3 of 10
Victor Stalinraj, Erasmus Medical Center, Netherlands
Characterization of DPP4 as the Functional Receptor for Middle East Respiratory Syndrome Coronavirus

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
Room: Quandary Peak

Speaker 4 of 10
Monika Bajorek, Imperial College London, UK
Human RSV M Protein Interactions with Host Proteins Reveal New Cellular Ligands Involved in Viral Nuclear Localization and Innate Defense

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
Room: Quandary Peak

Speaker 5 of 10
Kavestri Yegambaram, University of Auckland, New Zealand
Protein Interactions Underpinning Movement of the Viral Polymerase Diverge in the Paramyxovirinae

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
Room: Quandary Peak

Speaker 6 of 10
Patricia S. Domingues, University of Glasgow, UK
Non-Canonical Interplay between Influenza Virus and the Host SUMO System

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
Room: Quandary Peak

Speaker 7 of 10
Raymond J. Pickles, University of North Carolina, Chapel Hill, USA
Respiratory Syncytial Virus NS2 Protein Promotes Shedding of Virus-Infected Epithelial Cells Resulting in Acute Distal Airway Obstruction

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
Room: Quandary Peak

Speaker 8 of 10
Christopher Brooke, NIAID, National Institutes of Health, USA
Illuminating the Dark Matter of Influenza A Virus Infection: Dynamic Viral Gene Expression Patterns within the “Non-Infectious” Virus Population

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
Room: Quandary Peak

Speaker 9 of 10
Nicholas S. Heaton, Icahn School of Medicine at Mount Sinai, USA
Genome-Wide Mutagenesis of Influenza Virus: Unique Plasticity of the Hemagglutinin and NS1 Proteins

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
Room: Quandary Peak

Speaker 10 of 10
Hugh D. Mitchell, Pacific Northwest National Laboratory, USA
Integration of Proteomics Data Focuses Pathogenicity Pathways from Influenza Infection

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 1 of 8
* John Hiscott, Vaccine & Gene Therapy Institute of Florida, USA


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 2 of 8
David E. Levy, New York University School of Medicine, USA
Regulation of IFN Production and Response during Viral Infections


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 3 of 8
Eva-Katharina Pauli, Boston College, USA
USP15 Promotes RIG-I Antiviral Signaling by Stabilizing TRIM25


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 4 of 8
Sun Hur, Harvard Medical School, USA
RIG-I Forms Signaling-Competent Filaments in an ATP-Dependent and Ubiquitin-Independent Manner


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 5 of 8
Hao-Sen Chiang, National Taiwan University, Taiwan
GEF-H1 Mediates Microtubule-Dependent Sensing of Nucleic Acids for Antiviral Host Defenses


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 6 of 8
Chen Seng Ng, Kyoto University, Japan
Encephalomyocarditis Virus Disrupts Stress Granules, the Critical Platform for Triggering Antiviral Innate Immune Responses


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 7 of 8
Søren Riis Paludan, University of Aarhus, Denmark
Gammaherpesviruses Evade Innate Immune Activation via Cytosolic DNA Sensors to Allow Establishment of Chronic Infection


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 8 of 8
Pingwei Li, Texas A&M University, USA
Cyclic GMP-AMP Synthase is Activated by Double-Stranded DNA- Induced Oligomerization


Monday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 20 | 5:00PM - 7:00PM
Virus-Host Interactions
Room: Quandary Peak
Host factors required for replication, impact of viral infection in cell functions.
Speaker 1 of 5
* Tracy Hussell, University of Manchester, UK

Monday, January 20 | 5:00PM - 7:00PM
Virus-Host Interactions
Room: Quandary Peak
Host factors required for replication, impact of viral infection in cell functions.
Speaker 2 of 5
Yoshihiro Kawaoka, University of Wisconsin / University of Tokyo, USA
Influenza Virus Pathogenesis and Transmission

Monday, January 20 | 5:00PM - 7:00PM
Virus-Host Interactions
Room: Quandary Peak
Host factors required for replication, impact of viral infection in cell functions.
Speaker 3 of 5
Ursula J. Buchholz, NIAID, National Institutes of Health, USA
Evasion of the Adaptive Immune Response by HRSV and HMPV

Monday, January 20 | 5:00PM - 7:00PM
Virus-Host Interactions
Room: Quandary Peak
Host factors required for replication, impact of viral infection in cell functions.
Speaker 4 of 5
J. Kenneth Baillie, University of Edinburgh, UK
Host Genetic Susceptibility and Viral Pathogenesis

Monday, January 20 | 5:00PM - 7:00PM
Virus-Host Interactions
Room: Quandary Peak
Host factors required for replication, impact of viral infection in cell functions.
Speaker 5 of 5
Sharon K. Kuss, University of Texas Southwestern Medical Center, USA
Short Talk: Influenza A Virus RNA Splicing is Regulated by Cellular Proteins NS1-BP and hnRNP K

Monday, January 20 | 5:00PM - 7:00PM
Effector Responses and Viral Evasion
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 1 of 5
* Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA


Monday, January 20 | 5:00PM - 7:00PM
Effector Responses and Viral Evasion
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 2 of 5
Sara R. Cherry, University of Pennsylvania, USA
Autophagy Nutrient Signaling and Antiviral Defenses


Monday, January 20 | 5:00PM - 7:00PM
Effector Responses and Viral Evasion
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 3 of 5
Kanako Kuniyoshi, iOsaka University, Japan
Short Talk: Pivotal Role of RNA-Binding E3 Ubiquitin Ligase Mex3c in RIG-I-Mediated Antiviral Innate Immunity


Monday, January 20 | 5:00PM - 7:00PM
Effector Responses and Viral Evasion
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 4 of 5
Michael Gale, Jr., University of Washington, USA
Differential Innate Antiviral Effector Responses Impart Outcome of Pathogenic and Nonpathogenic Flavivirus Infection


Monday, January 20 | 5:00PM - 7:00PM
Effector Responses and Viral Evasion
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 5 of 5
Andrew G. Bowie, Trinity College Dublin, Ireland
Unexpected Roles for the TLR Adaptors TRAM and SARM in Anti-Viral Gene Induction


Monday, January 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud/Shavano


Monday, January 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Crestone/Red Cloud/Shavano


Tuesday, January 21 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud/Shavano


Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 1 of 7
* Charles M. Rice, Rockefeller University, USA

Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 2 of 7
Teunis B.H. Geijtenbeek, University of Amsterdam, Netherlands
C-Type Lectin Receptors as Virus Sensors or ‘Dupes’

Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 3 of 7
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Long Non-Coding RNA and Innate Immunity

Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 4 of 7
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Innate Immune Sensing of Cytosolic DNA

Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 5 of 7
Juris A. Grasis, San Diego State University, USA
Short Talk: Viral Recognition in the Basal Metazoan Hydra

Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 6 of 7
Akshay A. D'Cruz, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: A Two-Site Interaction Underpins TRIM25 Activation of the RIG-I Anti-Viral Response

Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 7 of 7
Karl-Peter Hopfner, Ludwig-Maximilians-University Munich, Germany
Talk Title to be Announced

Tuesday, January 21 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, January 21 | 11:15AM - 1:00PM
Poster Setup
Room: Crestone/Red Cloud/Shavano


Tuesday, January 21 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, January 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone/Red Cloud/Shavano


Tuesday, January 21 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 21 | 5:00PM - 7:00PM
Innate Immunity in Pathogenesis
Room: Quandary Peak

Speaker 1 of 6
* Adolfo García-Sastre, Mount Sinai School of Medicine, USA

Tuesday, January 21 | 5:00PM - 7:00PM
Innate Immunity in Pathogenesis
Room: Quandary Peak

Speaker 2 of 6
* Ben Hale, University of Glasgow, UK

Tuesday, January 21 | 5:00PM - 7:00PM
Innate Immunity in Pathogenesis
Room: Quandary Peak

Speaker 3 of 6
Peter Staeheli, University of Freiburg, Germany
Role of Interferon in Influenza Virus Defense

Tuesday, January 21 | 5:00PM - 7:00PM
Innate Immunity in Pathogenesis
Room: Quandary Peak

Speaker 4 of 6
Cecilia Johansson, Imperial College London, UK
Interferon Responses to Respiratory Syncytial Virus (RSV) Infection

Tuesday, January 21 | 5:00PM - 7:00PM
Innate Immunity in Pathogenesis
Room: Quandary Peak

Speaker 5 of 6
Deborah J. Lenschow, Washington University School of Medicine, USA
Regulation of the Host Response to Viral Infection by ISG15

Tuesday, January 21 | 5:00PM - 7:00PM
Innate Immunity in Pathogenesis
Room: Quandary Peak

Speaker 6 of 6
Amy C. Graham, Montana State University, USA
Short Talk: Influenza A Virus Activates Mast Cells to Enhance Viral-Induced Pathology

Tuesday, January 21 | 5:00PM - 7:00PM
Signaling Responses to Virus Infection
This session is from Innate Immunity
Room: Longs/Grays Peaks
MAVS, STING, inflammasome.
Speaker 1 of 5
* Andrew G. Bowie, Trinity College Dublin, Ireland


Tuesday, January 21 | 5:00PM - 7:00PM
Signaling Responses to Virus Infection
This session is from Innate Immunity
Room: Longs/Grays Peaks
MAVS, STING, inflammasome.
Speaker 2 of 5
Yong-Jun Liu, Sanofi, USA
Biochemical Characterization of Nucleic Acid Sensors in Dendritic Cells


Tuesday, January 21 | 5:00PM - 7:00PM
Signaling Responses to Virus Infection
This session is from Innate Immunity
Room: Longs/Grays Peaks
MAVS, STING, inflammasome.
Speaker 3 of 5
Kate L. Jeffrey, Harvard Medical School, USA
Short Talk: Antiviral Defense in Mammals Mediated by Argonautes 2 and 4


Tuesday, January 21 | 5:00PM - 7:00PM
Signaling Responses to Virus Infection
This session is from Innate Immunity
Room: Longs/Grays Peaks
MAVS, STING, inflammasome.
Speaker 4 of 5
Glen N. Barber, University of Miami, USA
STING at the Crossroads of Cell-Intrinsic DNA Sensing


Tuesday, January 21 | 5:00PM - 7:00PM
Signaling Responses to Virus Infection
This session is from Innate Immunity
Room: Longs/Grays Peaks
MAVS, STING, inflammasome.
Speaker 5 of 5
Veit Hornung, Ludwig-Maximilians-University Munich, Germany
Spreading of Antiviral Immunity via Gap Junctions


Tuesday, January 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud/Shavano


Tuesday, January 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Crestone/Red Cloud/Shavano


Wednesday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud/Shavano


Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 1 of 7
* Peter J.M. Openshaw, Imperial College London, UK

Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 2 of 7
Tracy Hussell, University of Manchester, UK
Airway Immune Homeostasis

Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 3 of 7
Andreas Wack, Francis Crick Institute, UK
Short Talk: Interferon in Flu

Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 4 of 7
Ricardo Rajsbaum, University of Texas Medical Branch, USA
Short Talk: Activation of Ikk Epsilon

Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 5 of 7
Harry B. Greenberg, Stanford University, USA
Rotaviruses and Vaccines: Host Range, Pathogenesis and Innate Immunity - A Ménage a Trois

Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 6 of 7
Nicholas W. Lukacs, University of Michigan, USA
Talk Title to be Announced

Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 7 of 7
Akiko Iwasaki, HHMI/Yale University School of Medicine, USA
Linking Innate Recognition of Viruses to Adaptive Immunity

Wednesday, January 22 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, January 22 | 11:00AM - 1:00PM
Poster Setup
Room: Crestone/Red Cloud/Shavano


Wednesday, January 22 | 11:00AM - 2:30PM
On Own for Lunch and Recreation


Wednesday, January 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone/Red Cloud/Shavano


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
Room: Quandary Peak

Speaker 1 of 10
* Adolfo García-Sastre, Mount Sinai School of Medicine, USA

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
Room: Quandary Peak

Speaker 2 of 10
* Ursula J. Buchholz, NIAID, National Institutes of Health, USA

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
Room: Quandary Peak

Speaker 3 of 10
Bas Baaten, Sanford-Burnham-Prebys Medical Discovery Institute, USA
Antiviral Immunity to Influenza Virus at the Aged Nasal Mucosa

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
Room: Quandary Peak

Speaker 4 of 10
Tim Beaumont, AIMM Therapeutics, Netherlands
Human B Cells Specific for the RSV F Prefusion Protein are Highly Prevalent and Efficiently Reduce Respiratory Tract Infection by RSV

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
Room: Quandary Peak

Speaker 5 of 10
Emily A. Hemann, University of Washington, USA
The Contribution of Direct Infection of Pulmonary Plasmacytoid Dendritic Cells to Robust CD8 T Cell Responses in the Lungs during Influenza A Virus Infection

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
Room: Quandary Peak

Speaker 6 of 10
Rebecca J. Ortiz Marty, Nationwide Children's Hospital Research Institute, USA
Epitope Specificity and Function of T-Cell
Responses during Acute RSV Bronchiolitis and Memory in Children and Adults


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
Room: Quandary Peak

Speaker 7 of 10
Saranya Sridhar, Imperial College, UK
CD8+ T Cells Correlate with Protection against Symptomatic Illness Following Natural Pandemic Influenza Infection in Humans

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
Room: Quandary Peak

Speaker 8 of 10
Jeffrey C. Boyington, NIAID, National Institutes of Health, USA
Rational Design of an Influenza Hemagglutinin Stem Immunogen Enables Elicitation of Stem-Directed Neutralizing Antibodies

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
Room: Quandary Peak

Speaker 9 of 10
Nicole L. Kallewaard, MedImmune, USA
Characterization of Novel Human Monoclonal Antibodies that Neutralize all Influenza A Viruses

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
Room: Quandary Peak

Speaker 10 of 10
M. Gordon Joyce, US Military HIV Research Program, USA
Structure-Based Respiratory Syncytial Virus Vaccine Design

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 1 of 8
* Søren Riis Paludan, University of Aarhus, Denmark


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 2 of 8
Curt M. Horvath, Northwestern University, USA
Genomic Analysis Reveals Novel Sites of Virus-Induced RNA Transcription


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 3 of 8
Saumendra N. Sarkar, University of Pittsburgh Cancer Institute, USA
Mechanisms of Antiviral Activity of Human OASL


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 4 of 8
Jennifer H. Stuart, University of Cambridge, UK
Dual Mechanisms of Inhibition of Interferon Responses by Vaccinia Virus Protein C6


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 5 of 8
John Hiscott, Vaccine & Gene Therapy Institute of Florida, USA
Host Restriction Factor SAMHD1 Limits Human Retrovirus Infection of Monocytes via STING-Mediated Apoptosis


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 6 of 8
John W. Schoggins, University of Texas Southwestern Medical Center, USA
Expression Screens Identify a Viral Bias in Interferon-Induced Effector Specificity and a Requirement for cGAS in Antiviral Immunity


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 7 of 8
Sumana Sanyal, University of Hong Kong, Hong Kong
Viral Exploitation of Host Intracellular Trafficking Pathways upon Interferon Induction


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
This session is from Innate Immunity
Room: Longs/Grays Peaks

Speaker 8 of 8
Silke Paust, Baylor College of Medicine, USA
Vaccine Induced Memory NK Cells Protect from Lethal Influenza Infection


Wednesday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 22 | 5:00PM - 7:00PM
Specific Immunity: The Good and the Bad
Room: Quandary Peak

Speaker 1 of 5
* Kanta Subbarao, WHO Collaborating Centre for Reference and Research on Influenza, Australia

Wednesday, January 22 | 5:00PM - 7:00PM
Specific Immunity: The Good and the Bad
Room: Quandary Peak

Speaker 2 of 5
Peter J.M. Openshaw, Imperial College London, UK
Immunity to Respiratory Syncytial Virus (RSV) Infection

Wednesday, January 22 | 5:00PM - 7:00PM
Specific Immunity: The Good and the Bad
Room: Quandary Peak

Speaker 3 of 5
Patrick C. Wilson, University of Chicago, USA
Diversity Drives the Human B Cell Response to Influenza

Wednesday, January 22 | 5:00PM - 7:00PM
Specific Immunity: The Good and the Bad
Room: Quandary Peak

Speaker 4 of 5
Ethan C. Settembre, Novartis Vaccines, USA
Improving the Global Influenza Vaccine System

Wednesday, January 22 | 5:00PM - 7:00PM
Specific Immunity: The Good and the Bad
Room: Quandary Peak

Speaker 5 of 5
Cory J. Knudson, University of Iowa, USA
Short Talk: Memory CD8 T Cells Provide Protection against Respiratory Syncytial Virus Infection at the Cost of Severe Pulmonary Immunopathology

Wednesday, January 22 | 5:00PM - 7:00PM
Defense from Retroviruses
This session is from Innate Immunity
Room: Longs/Grays Peaks
Cell-intrinsic barriers to exogenous retroviruses and endogenous retroelements (APOBECs, TRIMs, tetherin, TREX1, SAMHD1).
Speaker 1 of 5
* Alexander Tarakhovsky, Rockefeller University, USA


Wednesday, January 22 | 5:00PM - 7:00PM
Defense from Retroviruses
This session is from Innate Immunity
Room: Longs/Grays Peaks
Cell-intrinsic barriers to exogenous retroviruses and endogenous retroelements (APOBECs, TRIMs, tetherin, TREX1, SAMHD1).
Speaker 2 of 5
Stephen P. Goff, Columbia University, USA
Silencing of Retroviral DNAs in Embryonic Stem Cells: Transacting Proteins, Chromatin Modifications, and Timing


Wednesday, January 22 | 5:00PM - 7:00PM
Defense from Retroviruses
This session is from Innate Immunity
Room: Longs/Grays Peaks
Cell-intrinsic barriers to exogenous retroviruses and endogenous retroelements (APOBECs, TRIMs, tetherin, TREX1, SAMHD1).
Speaker 3 of 5
Maroof Hasan, Novartis Institutes for BioMedical Research, Switzerland
Short Talk: Tail-Anchored TREX1 Prevents Liberation of Free Glycans with Immunogenic Potential through a DNase-Independent Function


Wednesday, January 22 | 5:00PM - 7:00PM
Defense from Retroviruses
This session is from Innate Immunity
Room: Longs/Grays Peaks
Cell-intrinsic barriers to exogenous retroviruses and endogenous retroelements (APOBECs, TRIMs, tetherin, TREX1, SAMHD1).
Speaker 4 of 5
Jan Rehwinkel, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Nucleotide Starvation: A SAMHD1-Dependent Strategy for Cell-Intrinsic Anti-Retroviral Defense


Wednesday, January 22 | 5:00PM - 7:00PM
Defense from Retroviruses
This session is from Innate Immunity
Room: Longs/Grays Peaks
Cell-intrinsic barriers to exogenous retroviruses and endogenous retroelements (APOBECs, TRIMs, tetherin, TREX1, SAMHD1).
Speaker 5 of 5
Jeremy Luban, University of Massachusetts Medical School, USA
TRIM5 is an Innate Immune Sensor for the HIV-1 Capsid Protein Lattice


Wednesday, January 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud/Shavano


Wednesday, January 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Crestone/Red Cloud/Shavano


Thursday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud/Shavano


Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
Room: Quandary Peak

Speaker 1 of 8
* Monika Bajorek, Imperial College London, UK

Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
Room: Quandary Peak

Speaker 2 of 8
Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Subversion of Innate Pathways by Influenza Virus

Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
Room: Quandary Peak

Speaker 3 of 8
* Thomas J. Braciale, University of Virginia, USA
Respiratory Dendritic Cells in the Control of Anti-Viral Effector and Memory T Cell Responses

Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
Room: Quandary Peak

Speaker 4 of 8
Jonathan A. McCullers, University of Tennessee Health Sciences Center, USA
The Importance of Virus-Mediated Immune Dysfunction in Secondary Bacterial Pneumonia following Influenza

Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
Room: Quandary Peak

Speaker 5 of 8
Lance K. Blevins, Wake Forest School of Medicine, USA
Short Talk: Coinfection with S. Pneumoniae Results in Decreases in Both the Quality and Quantity of Influenza Specific CD8+ T Cells

Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
Room: Quandary Peak

Speaker 6 of 8
Agnieszka Rynda-Apple, Montana State University, USA
Short Talk: Regulation of IFN-? by IL-13 Dictates the Susceptibility to Secondary Post-Influenza MRSA Pneumonia

Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
Room: Quandary Peak

Speaker 7 of 8
Charles J. Russell, St. Jude Children's Research Hospital, USA
Short Talk: Dynamics of Primary Parainfluenza Virus Infection and Protection from Reinfection are Determined by the Mode of Transmission while Pathogenesis is Determined by Distinct Viral and Host Factors

Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
Room: Quandary Peak

Speaker 8 of 8
Denise E. de Almeida Nagata, University of Michigan, USA
Short Talk: Epigenetic Control by TGFbeta1-Inducible SMYD3 H3K4 Methyltransferase Influences iTreg Development and Respiratory Syncytial Virus-Related Disease Progression

Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
This session is from Innate Immunity
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 1 of 7
* Veit Hornung, Ludwig-Maximilians-University Munich, Germany


Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
This session is from Innate Immunity
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 2 of 7
Alexander Tarakhovsky, Rockefeller University, USA
Epigenetic Regulation of Antiviral Immunity


Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
This session is from Innate Immunity
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 3 of 7
Andreas Pichlmair, Max-Planck Institute of Biochemistry, Germany
Nucleic Acid Binding Proteins with Antiviral Properties


Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
This session is from Innate Immunity
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 4 of 7
Maria-Carla Saleh, Institut Pasteur, France
Short Talk: Evidence of Long-Lasting Antiviral Immunity in Insects


Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
This session is from Innate Immunity
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 5 of 7
Charles M. Rice, Rockefeller University, USA
Antiviral Activities of Interferon-Stimulated Genes


Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
This session is from Innate Immunity
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 6 of 7
Sonja M. Best, NIAID, National Institutes of Health, USA
Short Talk: The Mechanism of Type I Interferon Antagonism by NS5 from Encephalitic Flaviviruses, TBEV and WNV


Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
This session is from Innate Immunity
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 7 of 7
Gaya K. Amarasinghe, Washington University in St. Louis, USA
A Structural Element at the 5'-End of Viral RNA Antagonizes IFIT1-Mediated Cell-Intrinsic Immunity


Thursday, January 23 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, January 23 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Thursday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 23 | 5:00PM - 7:00PM
Regulation and Resolution of Inflammation
Room: Quandary Peak
Immunoregulation, resolvins
Speaker 1 of 5
* Peter J.M. Openshaw, Imperial College London, UK

Thursday, January 23 | 5:00PM - 7:00PM
Regulation and Resolution of Inflammation
Room: Quandary Peak
Immunoregulation, resolvins
Speaker 2 of 5
Bali Pulendran, Stanford University School of Medicine, USA
Systems Vaccinology: Enabling Rational Vaccine Design with Systems Biology

Thursday, January 23 | 5:00PM - 7:00PM
Regulation and Resolution of Inflammation
Room: Quandary Peak
Immunoregulation, resolvins
Speaker 3 of 5
Bruce D. Levy, Brigham and Women's Hospital, USA
Specialized Pro-Resolving Mediators Promote the Resolution of Pathogen-Mediated Inflammation

Thursday, January 23 | 5:00PM - 7:00PM
Regulation and Resolution of Inflammation
Room: Quandary Peak
Immunoregulation, resolvins
Speaker 4 of 5
Luis Enjuanes, CNB-Spanish National Research Council, Spain
MERS and SARS Pathogenesis and Vaccines

Thursday, January 23 | 5:00PM - 7:00PM
Regulation and Resolution of Inflammation
Room: Quandary Peak
Immunoregulation, resolvins
Speaker 5 of 5
Ryan A. Langlois, University of Minnesota, USA
Short Talk: Long-Term Influenza A Virus Infected Cells are Critical for Repair of Respiratory Damage

Thursday, January 23 | 5:00PM - 7:00PM
Antiviral Innate Immunity in Disease
This session is from Innate Immunity
Room: Longs/Grays Peaks
Inflammation and immunopathology, interferonopathies (AGS, lupus).
Speaker 1 of 5
* Caetano Reis e Sousa, Francis Crick Institute, UK


Thursday, January 23 | 5:00PM - 7:00PM
Antiviral Innate Immunity in Disease
This session is from Innate Immunity
Room: Longs/Grays Peaks
Inflammation and immunopathology, interferonopathies (AGS, lupus).
Speaker 2 of 5
Yanick Crow, University of Edinburgh, UK
Human Type I Interferonopathies


Thursday, January 23 | 5:00PM - 7:00PM
Antiviral Innate Immunity in Disease
This session is from Innate Immunity
Room: Longs/Grays Peaks
Inflammation and immunopathology, interferonopathies (AGS, lupus).
Speaker 3 of 5
Carla V. Rothlin, Yale University, USA
Negative Regulation of Type I Interferons


Thursday, January 23 | 5:00PM - 7:00PM
Antiviral Innate Immunity in Disease
This session is from Innate Immunity
Room: Longs/Grays Peaks
Inflammation and immunopathology, interferonopathies (AGS, lupus).
Speaker 4 of 5
Roland W. Kolbeck, MedImmune, LLC, USA
New Approaches to the Treatment of Interferon-Driven Autoimmunity


Thursday, January 23 | 5:00PM - 7:00PM
Antiviral Innate Immunity in Disease
This session is from Innate Immunity
Room: Longs/Grays Peaks
Inflammation and immunopathology, interferonopathies (AGS, lupus).
Speaker 5 of 5
Romain Bouziat, Genentech, Inc., USA
Short Talk: Role of Reoviral Infections and Type 1 Interferon in Celiac Disease


Thursday, January 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud/Shavano


Thursday, January 23 | 8:00PM - 11:00PM
Entertainment
Room: Crestone/Red Cloud/Shavano


Thursday, January 23 | 8:00PM - 11:00PM
Cash Bar
Room: Crestone/Red Cloud/Shavano


Friday, January 24 | 10:25AM - 10:25AM
Departure


*Session Chair.