Web Desc
Innate Immunity to Viral Infections
joint with Pathogenesis of Respiratory Viruses
Organizer(s): Caetano Reis e Sousa, Kate A. Fitzgerald and Charles M. Rice
Date: January 19 - 24, 2014
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Roche
For important information on the coronavirus, please click here
Summary of Meeting:
Viruses pose a unique problem from the perspective of innate immunity in that they are biochemically similar to the host. This similarity has forced the evolution of specialized immune recognition mechanisms for detecting virus infection and of unique mechanisms for restricting virus replication. As such, innate immunity to viruses overlaps with that utilized for defense against other organisms but also displays key differences that are often overlooked in more general meetings on innate immunity. This meeting will highlight the similarities and differences in antiviral defense across vertebrate and non-vertebrate species. It aims to bring together specialists in virology, immunology and pathogenesis to discuss the mechanisms involved in virus/host discrimination, the effector responses involved in restricting virus spread and the impact of innate antiviral immunity on disease. The symposium will create the first forum for exchange of ideas between virologists, immunologists and clinicians, offering a unique opportunity for these disparate research communities to come together and look at antiviral immunity from the perspective of contemporary medicine and biology. Importantly, this meeting will take place concurrently with the symposium on 'Pathogenesis of Respiratory Viruses.' Joint plenary sessions and synergistic interactions between both meetings will further contribute to the development of an integrated view of viral disease, immunity and pathogenesis.
Scholarship Deadline: October 9 2013
Discounted Abstract Deadline: October 9 2013
Abstract Deadline: October 31 2013
Discounted Registration Deadline: November 19 2013
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Roche
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, January 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Monday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud/Shavano


Monday, January 20 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 1 of 3
* Adolfo García-Sastre, Mount Sinai School of Medicine, USA

Monday, January 20 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 2 of 3
* Caetano Reis e Sousa, Francis Crick Institute, UK
RLRs in Immunity to Viruses

Monday, January 20 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: Columbine Ballroom

Speaker 3 of 3
Peter M. Palese, Icahn School of Medicine at Mount Sinai, USA
Why Do Influenza Viruses Undergo Antigenic Drift and Shift and What Can We Do About It?

Monday, January 20 | 10:00AM - 10:20AM
Coffee Break
Room: Longs Peak Foyer


Monday, January 20 | 10:20AM - 12:00PM
Antiviral Strategies Across Taxa
Room: Longs/Grays Peaks
Virus defense strategies in bacteria, plants and invertebrates, CRISPR RNAs, RNAi, death.
Speaker 1 of 4
* Sara R. Cherry, University of Pennsylvania, USA

Monday, January 20 | 10:20AM - 12:00PM
Antiviral Strategies Across Taxa
Room: Longs/Grays Peaks
Virus defense strategies in bacteria, plants and invertebrates, CRISPR RNAs, RNAi, death.
Speaker 2 of 4
Luciano A. Marraffini, Rockefeller University, USA
Tolerance during CRISPR-Cas Immunity: Domesticating the Virus

Monday, January 20 | 10:20AM - 12:00PM
Antiviral Strategies Across Taxa
Room: Longs/Grays Peaks
Virus defense strategies in bacteria, plants and invertebrates, CRISPR RNAs, RNAi, death.
Speaker 3 of 4
Jean-Luc Imler, Institut de Biologie Moléculaire et Cellulaire, France
Sensing and Signaling Viral Infection in Drosophila

Monday, January 20 | 10:20AM - 12:00PM
Antiviral Strategies Across Taxa
Room: Longs/Grays Peaks
Virus defense strategies in bacteria, plants and invertebrates, CRISPR RNAs, RNAi, death.
Speaker 4 of 4
Shou-Wei Ding, University of California, Riverside, USA
RNAi as an Antiviral Strategy across Species, including Vertebrates

Monday, January 20 | 10:20AM - 12:00PM
Viral Entry and Replication
This session is from Respiratory Viruses
Room: Quandary Peak
Glycoprotein structure, viral entry and genome replication.
Speaker 1 of 4
* Yoshihiro Kawaoka, University of Wisconsin / University of Tokyo, USA


Monday, January 20 | 10:20AM - 12:00PM
Viral Entry and Replication
This session is from Respiratory Viruses
Room: Quandary Peak
Glycoprotein structure, viral entry and genome replication.
Speaker 2 of 4
Ian A. Wilson, The Scripps Research Institute, USA
Structural Basis of Influenza HA Function and Neutralization


Monday, January 20 | 10:20AM - 12:00PM
Viral Entry and Replication
This session is from Respiratory Viruses
Room: Quandary Peak
Glycoprotein structure, viral entry and genome replication.
Speaker 3 of 4
James E. Crowe, Jr., Vanderbilt University Medical Center, USA
Host-Virus Interactions during RSV Infection


Monday, January 20 | 10:20AM - 12:00PM
Viral Entry and Replication
This session is from Respiratory Viruses
Room: Quandary Peak
Glycoprotein structure, viral entry and genome replication.
Speaker 4 of 4
Robert A. Lamb, Northwestern University, USA
The Mechanism of Entry into Cells by Membrane Fusion for Respiratory Negative Strand Viruses


Monday, January 20 | 12:00PM - 1:00PM
Poster Setup
Room: Crestone/Red Cloud/Shavano


Monday, January 20 | 12:00PM - 2:30PM
On Own for Lunch and Recreation


Monday, January 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone/Red Cloud/Shavano


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
Room: Longs/Grays Peaks

Speaker 1 of 8
* John Hiscott, Vaccine & Gene Therapy Institute of Florida, USA

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
Room: Longs/Grays Peaks

Speaker 2 of 8
David E. Levy, New York University School of Medicine, USA
Regulation of IFN Production and Response during Viral Infections

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
Room: Longs/Grays Peaks

Speaker 3 of 8
Eva-Katharina Pauli, Boston College, USA
USP15 Promotes RIG-I Antiviral Signaling by Stabilizing TRIM25

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
Room: Longs/Grays Peaks

Speaker 4 of 8
Sun Hur, Harvard Medical School, USA
RIG-I Forms Signaling-Competent Filaments in an ATP-Dependent and Ubiquitin-Independent Manner

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
Room: Longs/Grays Peaks

Speaker 5 of 8
Hao-Sen Chiang, National Taiwan University, Taiwan
GEF-H1 Mediates Microtubule-Dependent Sensing of Nucleic Acids for Antiviral Host Defenses

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
Room: Longs/Grays Peaks

Speaker 6 of 8
Chen Seng Ng, Kyoto University, Japan
Encephalomyocarditis Virus Disrupts Stress Granules, the Critical Platform for Triggering Antiviral Innate Immune Responses

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
Room: Longs/Grays Peaks

Speaker 7 of 8
Søren Riis Paludan, University of Aarhus, Denmark
Gammaherpesviruses Evade Innate Immune Activation via Cytosolic DNA Sensors to Allow Establishment of Chronic Infection

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Innate Virus Sensors
Room: Longs/Grays Peaks

Speaker 8 of 8
Pingwei Li, Texas A&M University, USA
Cyclic GMP-AMP Synthase is Activated by Double-Stranded DNA- Induced Oligomerization

Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 1 of 10
* James E. Crowe, Jr., Vanderbilt University Medical Center, USA


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 2 of 10
* Cecilia Johansson, Imperial College London, UK


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 3 of 10
Victor Stalinraj, Erasmus Medical Center, Netherlands
Characterization of DPP4 as the Functional Receptor for Middle East Respiratory Syndrome Coronavirus


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 4 of 10
Monika Bajorek, Imperial College London, UK
Human RSV M Protein Interactions with Host Proteins Reveal New Cellular Ligands Involved in Viral Nuclear Localization and Innate Defense


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 5 of 10
Kavestri Yegambaram, University of Auckland, New Zealand
Protein Interactions Underpinning Movement of the Viral Polymerase Diverge in the Paramyxovirinae


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 6 of 10
Patricia S. Domingues, University of Glasgow, UK
Non-Canonical Interplay between Influenza Virus and the Host SUMO System


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 7 of 10
Raymond J. Pickles, University of North Carolina, Chapel Hill, USA
Respiratory Syncytial Virus NS2 Protein Promotes Shedding of Virus-Infected Epithelial Cells Resulting in Acute Distal Airway Obstruction


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 8 of 10
Christopher Brooke, NIAID, National Institutes of Health, USA
Illuminating the Dark Matter of Influenza A Virus Infection: Dynamic Viral Gene Expression Patterns within the “Non-Infectious” Virus Population


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 9 of 10
Nicholas S. Heaton, Icahn School of Medicine at Mount Sinai, USA
Genome-Wide Mutagenesis of Influenza Virus: Unique Plasticity of the Hemagglutinin and NS1 Proteins


Monday, January 20 | 2:30PM - 4:30PM
Workshop 1: Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 10 of 10
Hugh D. Mitchell, Pacific Northwest National Laboratory, USA
Integration of Proteomics Data Focuses Pathogenicity Pathways from Influenza Infection


Monday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 20 | 5:00PM - 7:00PM
Effector Responses and Viral Evasion
Room: Longs/Grays Peaks

Speaker 1 of 5
* Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA

Monday, January 20 | 5:00PM - 7:00PM
Effector Responses and Viral Evasion
Room: Longs/Grays Peaks

Speaker 2 of 5
Sara R. Cherry, University of Pennsylvania, USA
Autophagy Nutrient Signaling and Antiviral Defenses

Monday, January 20 | 5:00PM - 7:00PM
Effector Responses and Viral Evasion
Room: Longs/Grays Peaks

Speaker 3 of 5
Kanako Kuniyoshi, iOsaka University, Japan
Short Talk: Pivotal Role of RNA-Binding E3 Ubiquitin Ligase Mex3c in RIG-I-Mediated Antiviral Innate Immunity

Monday, January 20 | 5:00PM - 7:00PM
Effector Responses and Viral Evasion
Room: Longs/Grays Peaks

Speaker 4 of 5
Michael Gale, Jr., University of Washington, USA
Differential Innate Antiviral Effector Responses Impart Outcome of Pathogenic and Nonpathogenic Flavivirus Infection

Monday, January 20 | 5:00PM - 7:00PM
Effector Responses and Viral Evasion
Room: Longs/Grays Peaks

Speaker 5 of 5
Andrew G. Bowie, Trinity College Dublin, Ireland
Unexpected Roles for the TLR Adaptors TRAM and SARM in Anti-Viral Gene Induction

Monday, January 20 | 5:00PM - 7:00PM
Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak
Host factors required for replication, impact of viral infection in cell functions.
Speaker 1 of 5
* Tracy Hussell, University of Manchester, UK


Monday, January 20 | 5:00PM - 7:00PM
Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak
Host factors required for replication, impact of viral infection in cell functions.
Speaker 2 of 5
Yoshihiro Kawaoka, University of Wisconsin / University of Tokyo, USA
Influenza Virus Pathogenesis and Transmission


Monday, January 20 | 5:00PM - 7:00PM
Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak
Host factors required for replication, impact of viral infection in cell functions.
Speaker 3 of 5
Ursula J. Buchholz, NIAID, National Institutes of Health, USA
Evasion of the Adaptive Immune Response by HRSV and HMPV


Monday, January 20 | 5:00PM - 7:00PM
Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak
Host factors required for replication, impact of viral infection in cell functions.
Speaker 4 of 5
J. Kenneth Baillie, University of Edinburgh, UK
Host Genetic Susceptibility and Viral Pathogenesis


Monday, January 20 | 5:00PM - 7:00PM
Virus-Host Interactions
This session is from Respiratory Viruses
Room: Quandary Peak
Host factors required for replication, impact of viral infection in cell functions.
Speaker 5 of 5
Sharon K. Kuss, University of Texas Southwestern Medical Center, USA
Short Talk: Influenza A Virus RNA Splicing is Regulated by Cellular Proteins NS1-BP and hnRNP K


Monday, January 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud/Shavano


Monday, January 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Crestone/Red Cloud/Shavano


Tuesday, January 21 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud/Shavano


Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 1 of 7
* Charles M. Rice, Rockefeller University, USA

Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 2 of 7
Teunis B.H. Geijtenbeek, University of Amsterdam, Netherlands
C-Type Lectin Receptors as Virus Sensors or ‘Dupes’

Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 3 of 7
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Long Non-Coding RNA and Innate Immunity

Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 4 of 7
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Innate Immune Sensing of Cytosolic DNA

Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 5 of 7
Juris A. Grasis, San Diego State University, USA
Short Talk: Viral Recognition in the Basal Metazoan Hydra

Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 6 of 7
Akshay A. D'Cruz, Australia
Short Talk: A Two-Site Interaction Underpins TRIM25 Activation of the RIG-I Anti-Viral Response

Tuesday, January 21 | 8:00AM - 11:15AM
Virus Detection by the Host (Joint)
Room: Columbine Ballroom
Cell-intrinsic (RLRs, DNA sensors), cell-extrinsic (TLRs, CLRs).
Speaker 7 of 7
Karl-Peter Hopfner, Ludwig-Maximilians-University Munich, Germany
Talk Title to be Announced

Tuesday, January 21 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, January 21 | 11:00AM - 1:00PM
Poster Setup
Room: Crestone/Red Cloud/Shavano


Tuesday, January 21 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, January 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone/Red Cloud/Shavano


Tuesday, January 21 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 21 | 5:00PM - 7:00PM
Signaling Responses to Virus Infection
Room: Longs/Grays Peaks
MAVS, STING, inflammasome.
Speaker 1 of 5
* Andrew G. Bowie, Trinity College Dublin, Ireland

Tuesday, January 21 | 5:00PM - 7:00PM
Signaling Responses to Virus Infection
Room: Longs/Grays Peaks
MAVS, STING, inflammasome.
Speaker 2 of 5
Yong-Jun Liu, Sanofi, USA
Biochemical Characterization of Nucleic Acid Sensors in Dendritic Cells

Tuesday, January 21 | 5:00PM - 7:00PM
Signaling Responses to Virus Infection
Room: Longs/Grays Peaks
MAVS, STING, inflammasome.
Speaker 3 of 5
Kate L. Jeffrey, Harvard Medical School, USA
Short Talk: Antiviral Defense in Mammals Mediated by Argonautes 2 and 4

Tuesday, January 21 | 5:00PM - 7:00PM
Signaling Responses to Virus Infection
Room: Longs/Grays Peaks
MAVS, STING, inflammasome.
Speaker 4 of 5
Glen N. Barber, University of Miami, USA
STING at the Crossroads of Cell-Intrinsic DNA Sensing

Tuesday, January 21 | 5:00PM - 7:00PM
Signaling Responses to Virus Infection
Room: Longs/Grays Peaks
MAVS, STING, inflammasome.
Speaker 5 of 5
Veit Hornung, Ludwig-Maximilians-University Munich, Germany
Spreading of Antiviral Immunity via Gap Junctions

Tuesday, January 21 | 5:00PM - 7:00PM
Innate Immunity in Pathogenesis
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 1 of 6
* Adolfo García-Sastre, Mount Sinai School of Medicine, USA


Tuesday, January 21 | 5:00PM - 7:00PM
Innate Immunity in Pathogenesis
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 2 of 6
* Ben Hale, University of Glasgow, UK


Tuesday, January 21 | 5:00PM - 7:00PM
Innate Immunity in Pathogenesis
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 3 of 6
Peter Staeheli, University of Freiburg, Germany
Role of Interferon in Influenza Virus Defense


Tuesday, January 21 | 5:00PM - 7:00PM
Innate Immunity in Pathogenesis
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 4 of 6
Cecilia Johansson, Imperial College London, UK
Interferon Responses to Respiratory Syncytial Virus (RSV) Infection


Tuesday, January 21 | 5:00PM - 7:00PM
Innate Immunity in Pathogenesis
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 5 of 6
Deborah J. Lenschow, Washington University School of Medicine, USA
Regulation of the Host Response to Viral Infection by ISG15


Tuesday, January 21 | 5:00PM - 7:00PM
Innate Immunity in Pathogenesis
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 6 of 6
Amy C. Graham, Montana State University, USA
Short Talk: Influenza A Virus Activates Mast Cells to Enhance Viral-Induced Pathology


Tuesday, January 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud/Shavano


Tuesday, January 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Crestone/Red Cloud/Shavano


Wednesday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud/Shavano


Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 1 of 7
* Peter J.M. Openshaw, Imperial College London, UK

Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 2 of 7
Tracy Hussell, University of Manchester, UK
Airway Immune Homeostasis

Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 3 of 7
Andreas Wack, Francis Crick Institute, UK
Short Talk: Interferon in Flu

Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 4 of 7
Ricardo Rajsbaum, University of Texas Medical Branch, USA
Short Talk: Activation of Ikk Epsilon

Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 5 of 7
Harry B. Greenberg, Stanford University, USA
Rotaviruses and Vaccines: Host Range, Pathogenesis and Innate Immunity - A Ménage a Trois

Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 6 of 7
Nicholas W. Lukacs, University of Michigan, USA
Talk Title to be Announced

Wednesday, January 22 | 8:00AM - 11:00AM
Induction of Immunity at Epithelial Surfaces (Joint)
Room: Columbine Ballroom
Dendritic cells, innate responses in the lung, inflammation.
Speaker 7 of 7
Akiko Iwasaki, HHMI/Yale University School of Medicine, USA
Linking Innate Recognition of Viruses to Adaptive Immunity

Wednesday, January 22 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, January 22 | 11:00AM - 1:00PM
Poster Setup
Room: Crestone/Red Cloud/Shavano


Wednesday, January 22 | 11:00AM - 2:30PM
On Own for Lunch and Recreation


Wednesday, January 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone/Red Cloud/Shavano


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
Room: Longs/Grays Peaks

Speaker 1 of 8
* Søren Riis Paludan, University of Aarhus, Denmark

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
Room: Longs/Grays Peaks

Speaker 2 of 8
Curt M. Horvath, Northwestern University, USA
Genomic Analysis Reveals Novel Sites of Virus-Induced RNA Transcription

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
Room: Longs/Grays Peaks

Speaker 3 of 8
Saumendra N. Sarkar, University of Pittsburgh Cancer Institute, USA
Mechanisms of Antiviral Activity of Human OASL

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
Room: Longs/Grays Peaks

Speaker 4 of 8
Jennifer H. Stuart, University of Cambridge, UK
Dual Mechanisms of Inhibition of Interferon Responses by Vaccinia Virus Protein C6

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
Room: Longs/Grays Peaks

Speaker 5 of 8
John Hiscott, Vaccine & Gene Therapy Institute of Florida, USA
Host Restriction Factor SAMHD1 Limits Human Retrovirus Infection of Monocytes via STING-Mediated Apoptosis

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
Room: Longs/Grays Peaks

Speaker 6 of 8
John W. Schoggins, University of Texas Southwestern Medical Center, USA
Expression Screens Identify a Viral Bias in Interferon-Induced Effector Specificity and a Requirement for cGAS in Antiviral Immunity

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
Room: Longs/Grays Peaks

Speaker 7 of 8
Sumana Sanyal, University of Hong Kong, Hong Kong
Viral Exploitation of Host Intracellular Trafficking Pathways upon Interferon Induction

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Antiviral Strategies
Room: Longs/Grays Peaks

Speaker 8 of 8
Silke Paust, Baylor College of Medicine, USA
Vaccine Induced Memory NK Cells Protect from Lethal Influenza Infection

Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 1 of 10
* Adolfo García-Sastre, Mount Sinai School of Medicine, USA


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 2 of 10
* Ursula J. Buchholz, NIAID, National Institutes of Health, USA


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 3 of 10
Bas Baaten, Sanford-Burnham-Prebys Medical Discovery Institute, USA
Antiviral Immunity to Influenza Virus at the Aged Nasal Mucosa


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 4 of 10
Tim Beaumont, AIMM Therapeutics, Netherlands
Human B Cells Specific for the RSV F Prefusion Protein are Highly Prevalent and Efficiently Reduce Respiratory Tract Infection by RSV


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 5 of 10
Emily A. Hemann, University of Washington, USA
The Contribution of Direct Infection of Pulmonary Plasmacytoid Dendritic Cells to Robust CD8 T Cell Responses in the Lungs during Influenza A Virus Infection


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 6 of 10
Rebecca J. Ortiz Marty, Nationwide Children's Hospital Research Institute, USA
Epitope Specificity and Function of T-Cell
Responses during Acute RSV Bronchiolitis and Memory in Children and Adults


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 7 of 10
Saranya Sridhar, Imperial College, UK
CD8+ T Cells Correlate with Protection against Symptomatic Illness Following Natural Pandemic Influenza Infection in Humans


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 8 of 10
Jeffrey C. Boyington, NIAID, National Institutes of Health, USA
Rational Design of an Influenza Hemagglutinin Stem Immunogen Enables Elicitation of Stem-Directed Neutralizing Antibodies


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 9 of 10
Nicole L. Kallewaard, MedImmune, USA
Characterization of Novel Human Monoclonal Antibodies that Neutralize all Influenza A Viruses


Wednesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Host Responses
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 10 of 10
M. Gordon Joyce, US Military HIV Research Program, USA
Structure-Based Respiratory Syncytial Virus Vaccine Design


Wednesday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 22 | 5:00PM - 7:00PM
Defense from Retroviruses
Room: Longs/Grays Peaks
Cell-intrinsic barriers to exogenous retroviruses and endogenous retroelements (APOBECs, TRIMs, tetherin, TREX1, SAMHD1).
Speaker 1 of 5
* Alexander Tarakhovsky, Rockefeller University, USA

Wednesday, January 22 | 5:00PM - 7:00PM
Defense from Retroviruses
Room: Longs/Grays Peaks
Cell-intrinsic barriers to exogenous retroviruses and endogenous retroelements (APOBECs, TRIMs, tetherin, TREX1, SAMHD1).
Speaker 2 of 5
Stephen P. Goff, Columbia University, USA
Silencing of Retroviral DNAs in Embryonic Stem Cells: Transacting Proteins, Chromatin Modifications, and Timing

Wednesday, January 22 | 5:00PM - 7:00PM
Defense from Retroviruses
Room: Longs/Grays Peaks
Cell-intrinsic barriers to exogenous retroviruses and endogenous retroelements (APOBECs, TRIMs, tetherin, TREX1, SAMHD1).
Speaker 3 of 5
Maroof Hasan, Novartis Institutes for BioMedical Research, Switzerland
Short Talk: Tail-Anchored TREX1 Prevents Liberation of Free Glycans with Immunogenic Potential through a DNase-Independent Function

Wednesday, January 22 | 5:00PM - 7:00PM
Defense from Retroviruses
Room: Longs/Grays Peaks
Cell-intrinsic barriers to exogenous retroviruses and endogenous retroelements (APOBECs, TRIMs, tetherin, TREX1, SAMHD1).
Speaker 4 of 5
Jan Rehwinkel, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Nucleotide Starvation: A SAMHD1-Dependent Strategy for Cell-Intrinsic Anti-Retroviral Defense

Wednesday, January 22 | 5:00PM - 7:00PM
Defense from Retroviruses
Room: Longs/Grays Peaks
Cell-intrinsic barriers to exogenous retroviruses and endogenous retroelements (APOBECs, TRIMs, tetherin, TREX1, SAMHD1).
Speaker 5 of 5
Jeremy Luban, University of Massachusetts Medical School, USA
TRIM5 is an Innate Immune Sensor for the HIV-1 Capsid Protein Lattice

Wednesday, January 22 | 5:00PM - 7:00PM
Specific Immunity: The Good and the Bad
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 1 of 5
* Kanta Subbarao, WHO Collaborating Centre for Reference and Research on Influenza, Australia


Wednesday, January 22 | 5:00PM - 7:00PM
Specific Immunity: The Good and the Bad
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 2 of 5
Peter J.M. Openshaw, Imperial College London, UK
Immunity to Respiratory Syncytial Virus (RSV) Infection


Wednesday, January 22 | 5:00PM - 7:00PM
Specific Immunity: The Good and the Bad
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 3 of 5
Patrick C. Wilson, University of Chicago, USA
Diversity Drives the Human B Cell Response to Influenza


Wednesday, January 22 | 5:00PM - 7:00PM
Specific Immunity: The Good and the Bad
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 4 of 5
Ethan C. Settembre, Novartis Vaccines, USA
Improving the Global Influenza Vaccine System


Wednesday, January 22 | 5:00PM - 7:00PM
Specific Immunity: The Good and the Bad
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 5 of 5
Cory J. Knudson, University of Iowa, USA
Short Talk: Memory CD8 T Cells Provide Protection against Respiratory Syncytial Virus Infection at the Cost of Severe Pulmonary Immunopathology


Wednesday, January 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud/Shavano


Wednesday, January 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Crestone/Red Cloud/Shavano


Thursday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud/Shavano


Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 1 of 7
* Veit Hornung, Ludwig-Maximilians-University Munich, Germany

Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 2 of 7
Alexander Tarakhovsky, Rockefeller University, USA
Epigenetic Regulation of Antiviral Immunity

Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 3 of 7
Andreas Pichlmair, Max-Planck Institute of Biochemistry, Germany
Nucleic Acid Binding Proteins with Antiviral Properties

Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 4 of 7
Maria-Carla Saleh, Institut Pasteur, France
Short Talk: Evidence of Long-Lasting Antiviral Immunity in Insects

Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 5 of 7
Charles M. Rice, Rockefeller University, USA
Antiviral Activities of Interferon-Stimulated Genes

Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 6 of 7
Sonja M. Best, NIAID, National Institutes of Health, USA
Short Talk: The Mechanism of Type I Interferon Antagonism by NS5 from Encephalitic Flaviviruses, TBEV and WNV

Thursday, January 23 | 8:00AM - 11:15AM
IFNs and ISGs
Room: Longs/Grays Peaks
Innate IFNs (a/b lambda) and their receptors, ISGs and their antiviral effects (mechanism of action, importance in infections, etc.)
Speaker 7 of 7
Gaya K. Amarasinghe, Washington University in St. Louis, USA
A Structural Element at the 5'-End of Viral RNA Antagonizes IFIT1-Mediated Cell-Intrinsic Immunity

Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 1 of 8
* Monika Bajorek, Imperial College London, UK


Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 2 of 8
Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Subversion of Innate Pathways by Influenza Virus


Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 3 of 8
* Thomas J. Braciale, University of Virginia, USA
Respiratory Dendritic Cells in the Control of Anti-Viral Effector and Memory T Cell Responses


Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 4 of 8
Jonathan A. McCullers, University of Tennessee Health Sciences Center, USA
The Importance of Virus-Mediated Immune Dysfunction in Secondary Bacterial Pneumonia following Influenza


Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 5 of 8
Lance K. Blevins, Wake Forest School of Medicine, USA
Short Talk: Coinfection with S. Pneumoniae Results in Decreases in Both the Quality and Quantity of Influenza Specific CD8+ T Cells


Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 6 of 8
Agnieszka Rynda-Apple, Montana State University, USA
Short Talk: Regulation of IFN-? by IL-13 Dictates the Susceptibility to Secondary Post-Influenza MRSA Pneumonia


Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 7 of 8
Charles J. Russell, St. Jude Children's Research Hospital, USA
Short Talk: Dynamics of Primary Parainfluenza Virus Infection and Protection from Reinfection are Determined by the Mode of Transmission while Pathogenesis is Determined by Distinct Viral and Host Factors


Thursday, January 23 | 8:00AM - 11:15AM
Virulence and Coinfections
This session is from Respiratory Viruses
Room: Quandary Peak

Speaker 8 of 8
Denise E. de Almeida Nagata, University of Michigan, USA
Short Talk: Epigenetic Control by TGFbeta1-Inducible SMYD3 H3K4 Methyltransferase Influences iTreg Development and Respiratory Syncytial Virus-Related Disease Progression


Thursday, January 23 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, January 23 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Thursday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 23 | 5:00PM - 7:00PM
Antiviral Innate Immunity in Disease
Room: Longs/Grays Peaks
Inflammation and immunopathology, interferonopathies (AGS, lupus).
Speaker 1 of 5
* Caetano Reis e Sousa, Francis Crick Institute, UK

Thursday, January 23 | 5:00PM - 7:00PM
Antiviral Innate Immunity in Disease
Room: Longs/Grays Peaks
Inflammation and immunopathology, interferonopathies (AGS, lupus).
Speaker 2 of 5
Yanick Crow, University of Edinburgh, UK
Human Type I Interferonopathies

Thursday, January 23 | 5:00PM - 7:00PM
Antiviral Innate Immunity in Disease
Room: Longs/Grays Peaks
Inflammation and immunopathology, interferonopathies (AGS, lupus).
Speaker 3 of 5
Carla V. Rothlin, Yale University, USA
Negative Regulation of Type I Interferons

Thursday, January 23 | 5:00PM - 7:00PM
Antiviral Innate Immunity in Disease
Room: Longs/Grays Peaks
Inflammation and immunopathology, interferonopathies (AGS, lupus).
Speaker 4 of 5
Roland W. Kolbeck, MedImmune, LLC, USA
New Approaches to the Treatment of Interferon-Driven Autoimmunity

Thursday, January 23 | 5:00PM - 7:00PM
Antiviral Innate Immunity in Disease
Room: Longs/Grays Peaks
Inflammation and immunopathology, interferonopathies (AGS, lupus).
Speaker 5 of 5
Romain Bouziat, Genentech, Inc., USA
Short Talk: Role of Reoviral Infections and Type 1 Interferon in Celiac Disease

Thursday, January 23 | 5:00PM - 7:00PM
Regulation and Resolution of Inflammation
This session is from Respiratory Viruses
Room: Quandary Peak
Immunoregulation, resolvins
Speaker 1 of 5
* Peter J.M. Openshaw, Imperial College London, UK


Thursday, January 23 | 5:00PM - 7:00PM
Regulation and Resolution of Inflammation
This session is from Respiratory Viruses
Room: Quandary Peak
Immunoregulation, resolvins
Speaker 2 of 5
Bali Pulendran, Stanford University School of Medicine, USA
Systems Vaccinology: Enabling Rational Vaccine Design with Systems Biology


Thursday, January 23 | 5:00PM - 7:00PM
Regulation and Resolution of Inflammation
This session is from Respiratory Viruses
Room: Quandary Peak
Immunoregulation, resolvins
Speaker 3 of 5
Bruce D. Levy, Brigham and Women's Hospital, USA
Specialized Pro-Resolving Mediators Promote the Resolution of Pathogen-Mediated Inflammation


Thursday, January 23 | 5:00PM - 7:00PM
Regulation and Resolution of Inflammation
This session is from Respiratory Viruses
Room: Quandary Peak
Immunoregulation, resolvins
Speaker 4 of 5
Luis Enjuanes, CNB-Spanish National Research Council, Spain
MERS and SARS Pathogenesis and Vaccines


Thursday, January 23 | 5:00PM - 7:00PM
Regulation and Resolution of Inflammation
This session is from Respiratory Viruses
Room: Quandary Peak
Immunoregulation, resolvins
Speaker 5 of 5
Ryan A. Langlois, University of Minnesota, USA
Short Talk: Long-Term Influenza A Virus Infected Cells are Critical for Repair of Respiratory Damage


Thursday, January 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud/Shavano


Thursday, January 23 | 8:00PM - 11:00PM
Entertainment
Room: Crestone/Red Cloud/Shavano


Thursday, January 23 | 8:00PM - 11:00PM
Cash Bar
Room: Crestone/Red Cloud/Shavano


Friday, January 24 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.