Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Signal Dynamics and Signal Integration in Development and Disease (2019J4)

Web Desc
Developmental Pathways and Cancer: Wnt, Notch and Hedgehog joint with Stem Cells and Cancer Organizer(s): Frederic J. de Sauvage, Mariann Bienz and Jon C. Aster Date: February 02 - 07, 2014 Location: Fairmont Banff Springs, Banff, AB, Canada Sponsored by Bayer HealthCare Pharmaceuticals, Cell Research, Genentech, Inc., OncoMed Pharmaceuticals, Inc., and Pfizer Inc. Summary of Meeting: Aberrant activation of the Wnt, Notch and Hedgehog pathways via mutations or ligand overexpression has been implicated in a large number of cancer types where they are involved in functions ranging from tumor initiation to cancer stem cell maintenance and angiogenesis. These findings have triggered intensive efforts in both academia and industry to identify targets in these pathways and develop drugs for the treatment of certain tumors. Agents targeting each one of these three pathways have now reached clinical trials, and the first one of these, Vismodegib, a Hedgehog Pathway Inhibitor, was approved in 2012 for the treatment of advanced basal cell carcinoma. This meeting will allow scientists from both academia and industry to review the latest results on the role of these pathways in cancer and share their experience with the development of drugs in preclinical models and in the clinic. Issues ranging from predicting clinical efficacy in animal models to identification of predictive diagnostics and potential mechanisms of acquired resistance are key to the success of these agents and will require a combined effort from the entire community studying these pathways. Scholarship Deadline: October 11 2013 Discounted Abstract Deadline: October 11 2013 Abstract Deadline: November 6 2013 Discounted Registration Deadline: December 3 2013 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Genentech, Inc. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Developmental Pathways and Cancer: Wnt, Notch and Hedgehog

joint with Stem Cells and Cancer

Organizer(s): Frederic J. de Sauvage, Mariann Bienz and Jon C. Aster

Date: February 02 - 07, 2014
Location: Fairmont Banff Springs, Banff, AB, Canada

Sponsored by Bayer HealthCare Pharmaceuticals, Cell Research, Genentech, Inc., OncoMed Pharmaceuticals, Inc., and Pfizer Inc.

Summary of Meeting:

Aberrant activation of the Wnt, Notch and Hedgehog pathways via mutations or ligand overexpression has been implicated in a large number of cancer types where they are involved in functions ranging from tumor initiation to cancer stem cell maintenance and angiogenesis. These findings have triggered intensive efforts in both academia and industry to identify targets in these pathways and develop drugs for the treatment of certain tumors. Agents targeting each one of these three pathways have now reached clinical trials, and the first one of these, Vismodegib, a Hedgehog Pathway Inhibitor, was approved in 2012 for the treatment of advanced basal cell carcinoma. This meeting will allow scientists from both academia and industry to review the latest results on the role of these pathways in cancer and share their experience with the development of drugs in preclinical models and in the clinic. Issues ranging from predicting clinical efficacy in animal models to identification of predictive diagnostics and potential mechanisms of acquired resistance are key to the success of these agents and will require a combined effort from the entire community studying these pathways.

Scholarship Deadline: October 11 2013

Discounted Abstract Deadline: October 11 2013

Abstract Deadline: November 6 2013

Discounted Registration Deadline: December 3 2013

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, February 02 \| 4:00PM - 8:00PM Arrival and Registration Room: Van Horne Foyer
Monday, February 03 \| 7:00AM - 8:00AM Breakfast Room: Mezzanine 2
Monday, February 03 \| 8:00AM - 11:15AM Signaling Pathways in Stem Cells This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 7 of 7 E. Alejandro Sweet-Cordero, Stanford University, USA Identification and Characterization of Tumor Propagating Cells in a Mouse Model of NSCLC
Monday, February 03 \| 8:00AM - 11:15AM Signaling Pathways in Stem Cells This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 6 of 7 Geoffrey M. Wahl, The Salk Institute, USA Investigating Human Breast Cancer through the Lens of Development
Monday, February 03 \| 8:00AM - 11:15AM Signaling Pathways in Stem Cells This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 5 of 7 Thea D. Tlsty, University of California, San Francisco, USA Stochastic Cellular States Associated with Malignancy
Monday, February 03 \| 8:00AM - 11:15AM Signaling Pathways in Stem Cells This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 4 of 7 Pantelis Rompolas, Yale University School of Medicine, USA Short Talk: Spatial Organization within a Niche as a Determinant of Stem Cell Fate
Monday, February 03 \| 8:00AM - 11:15AM Signaling Pathways in Stem Cells This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 3 of 7 Nick Barker, Institute of Medical Biology, Singapore Short Talk: Lgr5+ve Gastric Stem Cells Divide Symmetrically to Effect Epithelial Homeostasis in the Pylorus
Monday, February 03 \| 8:00AM - 11:15AM Signaling Pathways in Stem Cells This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 2 of 7 Jürgen A. Knoblich, Institute of Molecular Biotechnology, Austria Using Drosophila as a Model System for Tumorigenesis and Cancer Stem Cells
Monday, February 03 \| 8:00AM - 11:15AM Signaling Pathways in Stem Cells This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 1 of 7 * Elaine V. Fuchs, Rockefeller University, USA
Monday, February 03 \| 8:00AM - 11:15AM Signaling Mechanisms at the Cell Surface Room: Van Horne Ballroom C Speaker 6 of 6 Yulu Cherry Liu, University of Toronto, Canada Short Talk: The PPFIA1-PP2A Protein Complex Regulates Kif7 Ciliary Trafficking and Hedgehog Signaling
Monday, February 03 \| 8:00AM - 11:15AM Signaling Mechanisms at the Cell Surface Room: Van Horne Ballroom C Speaker 5 of 6 Jeremy F. Reiter, University of California, San Francisco, USA Restricted Access: The Transition Zone Controls Ciliary Composition and Vertebrate Hh Signaling
Monday, February 03 \| 8:00AM - 11:15AM Signaling Mechanisms at the Cell Surface Room: Van Horne Ballroom C Speaker 4 of 6 * Stephen C. Blacklow, Harvard Medical School, USA A Tail of Two Sites: Structural Basis for Recognition of Notch Ligands by Mind Bomb Proteins
Monday, February 03 \| 8:00AM - 11:15AM Signaling Mechanisms at the Cell Surface Room: Van Horne Ballroom C Speaker 3 of 6 William I. Weis, Stanford University, USA Short Talk: Structural Basis of GSK-3 Regulation by Autoinhibition and by the Wnt Receptor LRP6
Monday, February 03 \| 8:00AM - 11:15AM Signaling Mechanisms at the Cell Surface Room: Van Horne Ballroom C Speaker 2 of 6 Xi He, Harvard Medical School, USA Understanding the Mechanism of Wnt/beta-Catenin Signaling
Monday, February 03 \| 8:00AM - 11:15AM Signaling Mechanisms at the Cell Surface Room: Van Horne Ballroom C Speaker 1 of 6 Stefano Piccolo, University of Padua, Italy Wnt Signaling through YAP and TAZ
Monday, February 03 \| 9:20AM - 9:40AM Coffee Break Room: Van Horne Foyer
Monday, February 03 \| 11:15AM - 5:00PM On Own for Lunch and Recreation
Monday, February 03 \| 11:15AM - 1:00PM Poster Setup Room: Mezzanine 2
Monday, February 03 \| 1:00PM - 10:00PM Poster Viewing Room: Mezzanine 2
Monday, February 03 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Monday, February 03 \| 5:00PM - 7:00PM Signaling Mechanisms and Cancer Room: Van Horne Ballroom C Speaker 4 of 4 Madelon M. Maurice, University Medical Center Utrecht, Netherlands Short Talk: Cancer Mutations Derail Wnt Signalling via Conformational Conversion of the Scaffold Protein Axin
Monday, February 03 \| 5:00PM - 7:00PM Signaling Mechanisms and Cancer Room: Van Horne Ballroom C Speaker 3 of 4 * Warren S. Pear, University of Pennsylvania, USA Targeting the Notch:Myc Axis in Cancer
Monday, February 03 \| 5:00PM - 7:00PM Signaling Mechanisms and Cancer Room: Van Horne Ballroom C Speaker 2 of 4 Holger Gerhardt, Max Delbrück Center for Molecular Medicine, Germany Dll4/Notch Dynamics in Vascular Branching
Monday, February 03 \| 5:00PM - 7:00PM Signaling Mechanisms and Cancer Room: Van Horne Ballroom C Speaker 1 of 4 Adolfo Ferrando, Columbia University, USA An Oncogenic Metabolic Switch Mediates Resistance to NOTCH1 Inhibition in T-ALL
Monday, February 03 \| 5:00PM - 7:00PM Shared Signals in Stem Cells and Cancer This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 1 of 5 * Thea D. Tlsty, University of California, San Francisco, USA
Monday, February 03 \| 5:00PM - 7:00PM Shared Signals in Stem Cells and Cancer This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 2 of 5 Philip A. Beachy, HHMI/Stanford University, USA The Jekyll and Hyde Nature of Hedgehog Signaling in Cancer: Insights from the Urinary Bladder
Monday, February 03 \| 5:00PM - 7:00PM Shared Signals in Stem Cells and Cancer This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 3 of 5 Carman Man Chung Li, Massachusetts Institute of Technology, USA Short Talk: The Roles of Pulmonary and Gastrointestinal Developmental Programs in Regulating Lung Cancer Metastasis
Monday, February 03 \| 5:00PM - 7:00PM Shared Signals in Stem Cells and Cancer This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 4 of 5 Tannishtha Reya, University of California, San Diego, USA Developmental Pathways in Stem Cells and Cancer
Monday, February 03 \| 5:00PM - 7:00PM Shared Signals in Stem Cells and Cancer This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 5 of 5 Elaine V. Fuchs, Rockefeller University, USA Signaling of Skin Stem Cells in Homeostasis and Cancer
Monday, February 03 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Mezzanine 2
Monday, February 03 \| 7:30PM - 10:00PM Poster Session 1 Room: Mezzanine 2
Tuesday, February 04 \| 7:00AM - 8:00AM Breakfast Room: Mezzanine 2
Tuesday, February 04 \| 8:00AM - 11:15AM Nuclear Responses and Tumorigenesis Room: Van Horne Ballroom C Speaker 1 of 6 * Jon C. Aster, Brigham and Women's Hospital, USA Determinants of Notch Target Gene Activation and Notch-“Addiction” in Cancer
Tuesday, February 04 \| 8:00AM - 11:15AM Nuclear Responses and Tumorigenesis Room: Van Horne Ballroom C Speaker 2 of 6 Raphael Kopan, University of Cincinnati College of Medicine, USA Can We Record the Nuclear Footprints of Notch Signaling in Single Cells?
Tuesday, February 04 \| 8:00AM - 11:15AM Nuclear Responses and Tumorigenesis Room: Van Horne Ballroom C Speaker 3 of 6 Mariann Bienz, MRC Laboratory of Molecular Biology, UK Nuclear Wnt Signaling
Tuesday, February 04 \| 8:00AM - 11:15AM Nuclear Responses and Tumorigenesis Room: Van Horne Ballroom C Speaker 4 of 6 Marian Waterman, University of California, Irvine, USA A New Link Between Wnt, Warburg Metabolism, Stem Cells and Cancer
Tuesday, February 04 \| 8:00AM - 11:15AM Nuclear Responses and Tumorigenesis Room: Van Horne Ballroom C Speaker 5 of 6 Henner F. Farin, Hubrecht Institute, Netherlands Short Talk: Wnt3 Gradient in Intestinal Epithelial Crypts Is Formed by Proliferative Dilution of Membrane-Associated Growth Factor
Tuesday, February 04 \| 8:00AM - 11:15AM Nuclear Responses and Tumorigenesis Room: Van Horne Ballroom C Speaker 6 of 6 Joseph Rosenbluh, Broad Institute, USA Short Talk: Global Detailed Characterization of WNT Dependencies
Tuesday, February 04 \| 8:00AM - 11:15AM Cancer Cell of Origin This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 1 of 6 * John E. Dick, Princess Margaret Cancer Centre, Canada
Tuesday, February 04 \| 8:00AM - 11:15AM Cancer Cell of Origin This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 2 of 6 Robert J. Wechsler-Reya, Sanford-Burnham Medical Research Institute, USA Stem Cells and the Origins of Medulloblastoma
Tuesday, February 04 \| 8:00AM - 11:15AM Cancer Cell of Origin This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 3 of 6 Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA Genetic Mouse Models of Neural Cancer: Unique Insights and Translational Tools for Therapeutic Development
Tuesday, February 04 \| 8:00AM - 11:15AM Cancer Cell of Origin This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 4 of 6 Laetitia J. Seguin, University of California, San Diego, USA Short Talk: beta3 Integrin/KRAS/RalB Complex Drives Tumor Stemness and Resistance to EGFR Inhibition
Tuesday, February 04 \| 8:00AM - 11:15AM Cancer Cell of Origin This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 5 of 6 Menno J. Oudhoff, Biomedical Research Centre, Canada Short Talk: Set7 at the Intersection between Hippo/Yap and Wnt/beta-Catenin Signalling in Intestinal Homeostasis, Regeneration and Cancer
Tuesday, February 04 \| 8:00AM - 11:15AM Cancer Cell of Origin This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 6 of 6 Leonard I. Zon, HHMI/Boston Children's Hospital, USA A Stem Cell Program Triggered at the Onset on Cancer
Tuesday, February 04 \| 9:20AM - 9:40AM Coffee Break Room: Van Horne Foyer
Tuesday, February 04 \| 11:15AM - 12:30PM Roundtable: Preclinical Models and Early Translation This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 1 of 6 * Craig T. Jordan, University of Colorado, Anschutz Medical Campus, USA
Tuesday, February 04 \| 11:15AM - 12:30PM Roundtable: Preclinical Models and Early Translation This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 2 of 6 * Tannishtha Reya, University of California, San Diego, USA
Tuesday, February 04 \| 11:15AM - 12:30PM Roundtable: Preclinical Models and Early Translation This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 3 of 6 Robert S. Kerbel, Sunnybrook Research Institute, Canada Recapitulating Postsurgical Adjuvant or Metastatic Therapy in Mice as a Strategy to Improve Predicting Clinical Outcomes
Tuesday, February 04 \| 11:15AM - 12:30PM Roundtable: Preclinical Models and Early Translation This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 4 of 6 Zena Werb, University of California, San Francisco, USA
Tuesday, February 04 \| 11:15AM - 12:30PM Roundtable: Preclinical Models and Early Translation This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 5 of 6 Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Tuesday, February 04 \| 11:15AM - 12:30PM Roundtable: Preclinical Models and Early Translation This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 6 of 6 David A. Cheresh, University of California, San Diego, USA
Tuesday, February 04 \| 11:15AM - 1:00PM Poster Setup Room: Mezzanine 2
Tuesday, February 04 \| 11:15AM - 5:00PM On Own for Lunch and Recreation
Tuesday, February 04 \| 1:00PM - 10:00PM Poster Viewing Room: Mezzanine 2
Tuesday, February 04 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Tuesday, February 04 \| 5:00PM - 7:15PM Developmental Pathways and Tumor Initiation Room: Van Horne Ballroom C Speaker 1 of 4 * Freddy Radtke, EPFL SV ISREC UPRAD, Switzerland Tumor Suppressive Roles of Notch in Epithelial Cells
Tuesday, February 04 \| 5:00PM - 7:15PM Developmental Pathways and Tumor Initiation Room: Van Horne Ballroom C Speaker 2 of 4 Owen J. Sansom, Beatson Institute of Cancer Research, UK mTORC1 Is Required Following Apc Loss
Tuesday, February 04 \| 5:00PM - 7:15PM Developmental Pathways and Tumor Initiation Room: Van Horne Ballroom C Speaker 3 of 4 Rune C.M. Toftgard, Karolinska Institutet, Sweden Hedgehog Signal Transduction and Cancer Initiation
Tuesday, February 04 \| 5:00PM - 7:15PM Developmental Pathways and Tumor Initiation Room: Van Horne Ballroom C Speaker 4 of 4 Philip H. Jones, Wellcome Trust Sanger Institute / University of Cambridge, UK Short Talk: Inhibition of Notch Signaling Confers Clonal Dominance In Esophageal Epithelium
Tuesday, February 04 \| 5:00PM - 7:00PM Cancer Stem Cells This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 1 of 4 Sean J. Morrison, University of Texas Southwestern Medical Center, USA Hematopoietic Stem Cells Require a Highly Regulated Rate of Protein Synthesis
Tuesday, February 04 \| 5:00PM - 7:00PM Cancer Stem Cells This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 2 of 4 * John E. Dick, Princess Margaret Cancer Centre, Canada Complex Mechanisms Underlie Intra-Tumoral Heterogeneity
Tuesday, February 04 \| 5:00PM - 7:00PM Cancer Stem Cells This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 3 of 4 Robert J. Vanner, Hospital for Sick Children, Canada Short Talk: Quiescent Therapy Resistant Sox2+ Cells Drive Hierarchical Growth and Relapse in Shh-Subgroup Medulloblastoma
Tuesday, February 04 \| 5:00PM - 7:00PM Cancer Stem Cells This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 4 of 4 Jeffrey M. Rosen, Baylor College of Medicine, USA Wnt and Fgf Signaling in Mammary Stem Cells and Breast Cancer
Tuesday, February 04 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Mezzanine 2
Tuesday, February 04 \| 7:30PM - 10:00PM Poster Session 2 Room: Mezzanine 2
Wednesday, February 05 \| 7:00AM - 8:00AM Breakfast Room: Mezzanine 2
Wednesday, February 05 \| 8:00AM - 11:00AM Stem Cells, Development and Cancer (Joint) Room: Van Horne Ballroom A/B Speaker 1 of 7 * Tannishtha Reya, University of California, San Diego, USA
Wednesday, February 05 \| 8:00AM - 11:00AM Stem Cells, Development and Cancer (Joint) Room: Van Horne Ballroom A/B Speaker 2 of 7 * Frederic J. de Sauvage, Genentech, Inc., USA
Wednesday, February 05 \| 8:00AM - 11:00AM Stem Cells, Development and Cancer (Joint) Room: Van Horne Ballroom A/B Speaker 3 of 7 Cédric Blanpain, Universite Libre de Bruxelles, Belgium Keynote Address: Developmental Pathways Regulating Stemness in Skin Cancers
Wednesday, February 05 \| 8:00AM - 11:00AM Stem Cells, Development and Cancer (Joint) Room: Van Horne Ballroom A/B Speaker 4 of 7 Roeland Nusse, HHMI/Stanford University, USA Wnt Signaling and Stem Cell Control
Wednesday, February 05 \| 8:00AM - 11:00AM Stem Cells, Development and Cancer (Joint) Room: Van Horne Ballroom A/B Speaker 5 of 7 Ciara Metcalfe, Genentech, USA Short Talk: Lgr5+ Stem Cells are Indispensible for Radiation-Induced Intestinal Regeneration
Wednesday, February 05 \| 8:00AM - 11:00AM Stem Cells, Development and Cancer (Joint) Room: Van Horne Ballroom A/B Speaker 6 of 7 Catriona H.M. Jamieson, University of California, San Diego, USA The Niche Specific Role of RNA Editing in Leukemia Stem Cell Generation
Wednesday, February 05 \| 8:00AM - 11:00AM Stem Cells, Development and Cancer (Joint) Room: Van Horne Ballroom A/B Speaker 7 of 7 David A. Cheresh, University of California, San Diego, USA Reversing Cancer Stemness and Drug Resistance
Wednesday, February 05 \| 9:30AM - 9:50AM Coffee Break Room: Van Horne Foyer
Wednesday, February 05 \| 11:00AM - 5:00PM On Own for Lunch and Recreation
Wednesday, February 05 \| 11:30AM - 1:00PM Poster Setup Room: Mezzanine 2
Wednesday, February 05 \| 1:00PM - 10:00PM Poster Viewing Room: Mezzanine 2
Wednesday, February 05 \| 2:30PM - 4:30PM Workshop This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 1 of 7 * Lauren I. R. Ehrlich, University of Texas at Austin, USA
Wednesday, February 05 \| 2:30PM - 4:30PM Workshop This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 2 of 7 Ho-Chou Tu, Children's Hospital Boston, USA The Pluripotency Factor LIN28 Promotes Colorectal Tumorigenesis and Progression
Wednesday, February 05 \| 2:30PM - 4:30PM Workshop This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 3 of 7 Andrew C. White, Cornell University, USA Stem Cell Quiescence Acts as a Tumor Suppressor Mechanism in Hair Follicle Initiated Squamous Tumors
Wednesday, February 05 \| 2:30PM - 4:30PM Workshop This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 4 of 7 Ching-Cheng Chen, City of Hope National Medical Center, USA Acute Myeloid Leukemia-Derived Exosomes Transform Bone Marrow Niche into Leukemic Niche
Wednesday, February 05 \| 2:30PM - 4:30PM Workshop This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 5 of 7 Borhane Guezguez, McMaster Stem Cell and Cancer Research Institute, Canada Modeling the Human Bone Marrow HSC Niche in vivo
Wednesday, February 05 \| 2:30PM - 4:30PM Workshop This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 6 of 7 Martin Lackmann, Monash University, Australia Therapeutic Targeting of EphA3 in the Tumor Microenvironment Inhibits Cancer Growth
Wednesday, February 05 \| 2:30PM - 4:30PM Workshop This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 7 of 7 Gerald Schwank, ETH Zurich, Switzerland Genome Editing by CRISPR/Cas9 in Intestinal Stem Cell Organoids
Wednesday, February 05 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Wednesday, February 05 \| 5:00PM - 7:00PM Developmental Pathways in Cancer and Metastasis Room: Van Horne Ballroom C Speaker 1 of 4 * Michael D. Taylor, Hospital for Sick Children, Canada Heterogeneity and Therapeutic Resistance Amongst the Shh Medulloblastomas
Wednesday, February 05 \| 5:00PM - 7:00PM Developmental Pathways in Cancer and Metastasis Room: Van Horne Ballroom C Speaker 2 of 4 Kimberly Stegmaier, Dana-Farber Cancer Institute, USA Targeting Mutated NOTCH1 in Cancer
Wednesday, February 05 \| 5:00PM - 7:00PM Developmental Pathways in Cancer and Metastasis Room: Van Horne Ballroom C Speaker 3 of 4 Joerg Huelsken, Ecole Polytechnique Fédérale de Lausanne, Switzerland Targeting Tumor/Stroma Interactions to Overcome Metastasis
Wednesday, February 05 \| 5:00PM - 7:00PM Developmental Pathways in Cancer and Metastasis Room: Van Horne Ballroom C Speaker 4 of 4 Taran S. Gujral, Harvard Medical School, USA Short Talk: Wnt5-Fzd2 Signaling Drives Epithelial-Mesenchymal Transition, Tumor Progression, and Metastasis
Wednesday, February 05 \| 5:00PM - 7:15PM Cancer in Context: The Microenvironment and Metastasis This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 1 of 6 * Jeffrey M. Rosen, Baylor College of Medicine, USA
Wednesday, February 05 \| 5:00PM - 7:15PM Cancer in Context: The Microenvironment and Metastasis This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 2 of 6 Zena Werb, University of California, San Francisco, USA Imaging the Immune Microenvironment in Mammary Development and Cancer
Wednesday, February 05 \| 5:00PM - 7:15PM Cancer in Context: The Microenvironment and Metastasis This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 3 of 6 Lauren I. R. Ehrlich, University of Texas at Austin, USA Short Talk: The Tumor Microenvironment Promotes Tumorigenesis in T-ALL
Wednesday, February 05 \| 5:00PM - 7:15PM Cancer in Context: The Microenvironment and Metastasis This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 4 of 6 Jing Yang, University of California, San Diego, USA Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis
Wednesday, February 05 \| 5:00PM - 7:15PM Cancer in Context: The Microenvironment and Metastasis This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 5 of 6 Manuel Valiente, Memorial Sloan-Kettering Cancer Center, USA Short Talk: Serpins Promote Cancer Cell Survival and Vascular Cooption in Brain Metastasis
Wednesday, February 05 \| 5:00PM - 7:15PM Cancer in Context: The Microenvironment and Metastasis This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 6 of 6 Carla F. Kim, Boston Children's Hospital, USA Microenvironmental Regulation of Lung Stem Cell Differentiation
Wednesday, February 05 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Mezzanine 2
Wednesday, February 05 \| 7:30PM - 10:00PM Poster Session 3 Room: Mezzanine 2
Thursday, February 06 \| 7:00AM - 8:00AM Breakfast Room: Mezzanine 2
Thursday, February 06 \| 8:00AM - 11:15AM Emerging Cancer Drug Targets in Development Pathways Room: Van Horne Ballroom C Speaker 1 of 6 * Weilan Ye, Genentech, Inc., USA The Norrin-Mediated Canonical Wnt Signaling Pathway Regulates Vascular Integrity
Thursday, February 06 \| 8:00AM - 11:15AM Emerging Cancer Drug Targets in Development Pathways Room: Van Horne Ballroom C Speaker 2 of 6 Feng Cong, Novartis Institutes for BioMedical Research, USA Control of Wnt Signaling by Ubiquitin and Tankyrase
Thursday, February 06 \| 8:00AM - 11:15AM Emerging Cancer Drug Targets in Development Pathways Room: Van Horne Ballroom C Speaker 3 of 6 Babita Madan, DUKE-NUS Graduate Medical School, Singapore Short Talk: Novel Porcn Inhibitors Are Safe and Effective in the Treatment of Wnt-Dependent Cancers
Thursday, February 06 \| 8:00AM - 11:15AM Emerging Cancer Drug Targets in Development Pathways Room: Van Horne Ballroom C Speaker 4 of 6 Bradley E. Bernstein, Massachusetts General Hospital, USA Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-Like Cells
Thursday, February 06 \| 8:00AM - 11:15AM Emerging Cancer Drug Targets in Development Pathways Room: Van Horne Ballroom C Speaker 5 of 6 Austin Gurney, Napa Biotechnology Consulting, USA Targeting Stem Cell Pathways in Cancer
Thursday, February 06 \| 8:00AM - 11:15AM Emerging Cancer Drug Targets in Development Pathways Room: Van Horne Ballroom C Speaker 6 of 6 Raoul C.D.S. Coombes, Imperial College London, UK Short Talk: Antibodies to Nicastrin inhibit Invasion and Metastasis in Models of Breast Cancer
Thursday, February 06 \| 8:00AM - 11:15AM New Regulatory Pathways in Cancer This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 1 of 6 * Zena Werb, University of California, San Francisco, USA
Thursday, February 06 \| 8:00AM - 11:15AM New Regulatory Pathways in Cancer This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 2 of 6 Andreas Trumpp, German Cancer Research Center, Germany Mesenchymal and MDS Stem Cells Shape an Interactive Disease Unit in the Bone Marrow
Thursday, February 06 \| 8:00AM - 11:15AM New Regulatory Pathways in Cancer This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 3 of 6 Lewis A. Chodosh, University of Pennsylvania School of Medicine, USA Mechanisms Controlling Tumor Dormancy and Recurrence
Thursday, February 06 \| 8:00AM - 11:15AM New Regulatory Pathways in Cancer This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 4 of 6 Vishva M. Dixit, Genentech, Inc., USA Apoptosis and Cancer
Thursday, February 06 \| 8:00AM - 11:15AM New Regulatory Pathways in Cancer This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 5 of 6 Robert MacLeod, Ionis Pharmaceuticals, Inc., USA Short Talk: Preclinical and Early Clinical Evaluation of the Next Generation STAT3 Antisense Oligonucleotide STAT3rx/AZD9150
Thursday, February 06 \| 8:00AM - 11:15AM New Regulatory Pathways in Cancer This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 6 of 6 Daniel S. Pereira, Agensys, Inc, USA Short Talk: AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody (MMAE) Drug Conjugate as a Potential Therapeutic for Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia
Thursday, February 06 \| 9:20AM - 9:40AM Coffee Break Room: Van Horne Foyer
Thursday, February 06 \| 11:15AM - 12:15PM Special Lecture: Keynote Address (Joint) Room: Van Horne Ballroom A/B Speaker 1 of 1 Irving L. Weissman, Stanford University, USA Reversing Cancer Stemness and Drug Resistance
Thursday, February 06 \| 12:15PM - 5:00PM On Own for Lunch and Recreation
Thursday, February 06 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Thursday, February 06 \| 5:00PM - 7:00PM Targeting Developmental Pathways: Clinical Experience Room: Van Horne Ballroom C Speaker 1 of 4 Gavin O. Thurston, Regeneron Pharmaceuticals Inc., USA Blockade of Dll4-Notch Signaling in Tumor Angiogenesis
Thursday, February 06 \| 5:00PM - 7:00PM Targeting Developmental Pathways: Clinical Experience Room: Van Horne Ballroom C Speaker 2 of 4 Jean Y. Tang, Stanford University School of Medicine, USA Hedgehog Pathway Inhibitor Clinical Trials
Thursday, February 06 \| 5:00PM - 7:00PM Targeting Developmental Pathways: Clinical Experience Room: Van Horne Ballroom C Speaker 3 of 4 * Frederic J. de Sauvage, Genentech, Inc., USA Innate and Acquired Resistance to Hedgehog Pathways Inhibitors
Thursday, February 06 \| 5:00PM - 7:00PM Targeting Developmental Pathways: Clinical Experience Room: Van Horne Ballroom C Speaker 4 of 4 Lawrence Lum, University of Texas, Southwestern Medical Center, USA Short Talk: Extra-Mitochondrial Bcl-2 Anti-Apoptotic Proteins Regulate Gli Transcriptional Activity
Thursday, February 06 \| 5:00PM - 7:15PM Targeting Cancer Stem Cells: Trials and Translation This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 1 of 6 * Vishva M. Dixit, Genentech, Inc., USA
Thursday, February 06 \| 5:00PM - 7:15PM Targeting Cancer Stem Cells: Trials and Translation This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 2 of 6 Craig T. Jordan, University of Colorado, Anschutz Medical Campus, USA Targeting Metabolic Properties to More Effectively Eradicate Leukemia Stem Cells
Thursday, February 06 \| 5:00PM - 7:15PM Targeting Cancer Stem Cells: Trials and Translation This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 3 of 6 Annette Friebe, Nexigen GmbH, Germany Short Talk: Drugging the Undruggables - Cell-Permeable Peptide Antagonists Targeting the Wnt Signaling Pathway
Thursday, February 06 \| 5:00PM - 7:15PM Targeting Cancer Stem Cells: Trials and Translation This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 4 of 6 Peter Chu, Eclipse BioInnovations, USA Short Talk: Therapeutic Targeting of Cancer Stem Cells with BNC101, a Functional Anti-LGR5 Monoclonal Antibody
Thursday, February 06 \| 5:00PM - 7:15PM Targeting Cancer Stem Cells: Trials and Translation This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 5 of 6 Jeremy Naftali Rich, Cleveland Clinic, USA Partners in Crime: Tumor Stem Cells and the Tumor Microenvironment
Thursday, February 06 \| 5:00PM - 7:15PM Targeting Cancer Stem Cells: Trials and Translation This session is from Stem Cells and Cancer Room: Van Horne Ballroom A/B Speaker 6 of 6 Michael F. Clarke, Stanford University, USA Regulation of Normal and Cancer Stem Cell Self Renewal and Senescence by USP16
Thursday, February 06 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Mezzanine 2
Thursday, February 06 \| 8:00PM - 11:00PM Entertainment Room: Mezzanine 2
Thursday, February 06 \| 8:15PM - 11:00PM Cash Bar Room: Mezzanine 2
Friday, February 07 \| 10:25AM - 10:25AM Departure *Session Chair.