Web Desc
Developmental Pathways and Cancer: Wnt, Notch and Hedgehog
joint with Stem Cells and Cancer
Organizer(s): Frederic J. de Sauvage, Mariann Bienz and Jon C. Aster
Date: February 02 - 07, 2014
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by Bayer HealthCare Pharmaceuticals, Cell Research, Genentech, Inc., OncoMed Pharmaceuticals, Inc., and Pfizer Inc.
Summary of Meeting:
Aberrant activation of the Wnt, Notch and Hedgehog pathways via mutations or ligand overexpression has been implicated in a large number of cancer types where they are involved in functions ranging from tumor initiation to cancer stem cell maintenance and angiogenesis. These findings have triggered intensive efforts in both academia and industry to identify targets in these pathways and develop drugs for the treatment of certain tumors. Agents targeting each one of these three pathways have now reached clinical trials, and the first one of these, Vismodegib, a Hedgehog Pathway Inhibitor, was approved in 2012 for the treatment of advanced basal cell carcinoma. This meeting will allow scientists from both academia and industry to review the latest results on the role of these pathways in cancer and share their experience with the development of drugs in preclinical models and in the clinic. Issues ranging from predicting clinical efficacy in animal models to identification of predictive diagnostics and potential mechanisms of acquired resistance are key to the success of these agents and will require a combined effort from the entire community studying these pathways.
Scholarship Deadline: October 11 2013
Discounted Abstract Deadline: October 11 2013
Abstract Deadline: November 6 2013
Discounted Registration Deadline: December 3 2013
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer HealthCare PharmaceuticalsCell ResearchGenentech, Inc.OncoMed Pharmaceuticals, Inc.Pfizer Inc.
We gratefully acknowledge additional support for this conference from:
Bethyl Laboratories, Inc.CEDARLANECell Signaling Technology, Inc.Educational grant from Lilly
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
EMBO (European Molecular Biology Organization)
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 02 | 4:00PM - 8:00PM
Arrival and Registration
Room: Van Horne Foyer


Monday, February 03 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Monday, February 03 | 8:00AM - 11:15AM
Signaling Pathways in Stem Cells
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 7 of 7
E. Alejandro Sweet-Cordero, Stanford University, USA
Identification and Characterization of Tumor Propagating Cells in a Mouse Model of NSCLC


Monday, February 03 | 8:00AM - 11:15AM
Signaling Pathways in Stem Cells
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 6 of 7
Geoffrey M. Wahl, The Salk Institute, USA
Investigating Human Breast Cancer through the Lens of Development


Monday, February 03 | 8:00AM - 11:15AM
Signaling Pathways in Stem Cells
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 5 of 7
Thea D. Tlsty, University of California, San Francisco, USA
Stochastic Cellular States Associated with Malignancy


Monday, February 03 | 8:00AM - 11:15AM
Signaling Pathways in Stem Cells
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 4 of 7
Pantelis Rompolas, Yale University School of Medicine, USA
Short Talk: Spatial Organization within a Niche as a Determinant of Stem Cell Fate


Monday, February 03 | 8:00AM - 11:15AM
Signaling Pathways in Stem Cells
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 3 of 7
Nick Barker, Institute of Medical Biology, Singapore
Short Talk: Lgr5+ve Gastric Stem Cells Divide Symmetrically to Effect Epithelial Homeostasis in the Pylorus


Monday, February 03 | 8:00AM - 11:15AM
Signaling Pathways in Stem Cells
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 2 of 7
Jürgen A. Knoblich, Institute of Molecular Biotechnology, Austria
Using Drosophila as a Model System for Tumorigenesis and Cancer Stem Cells


Monday, February 03 | 8:00AM - 11:15AM
Signaling Pathways in Stem Cells
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 1 of 7
* Elaine V. Fuchs, Rockefeller University, USA


Monday, February 03 | 8:00AM - 11:15AM
Signaling Mechanisms at the Cell Surface
Room: Van Horne Ballroom C

Speaker 6 of 6
Yulu Cherry Liu, University of Toronto, Canada
Short Talk: The PPFIA1-PP2A Protein Complex Regulates Kif7 Ciliary Trafficking and Hedgehog Signaling

Monday, February 03 | 8:00AM - 11:15AM
Signaling Mechanisms at the Cell Surface
Room: Van Horne Ballroom C

Speaker 5 of 6
Jeremy F. Reiter, University of California, San Francisco, USA
Restricted Access: The Transition Zone Controls Ciliary Composition and Vertebrate Hh Signaling

Monday, February 03 | 8:00AM - 11:15AM
Signaling Mechanisms at the Cell Surface
Room: Van Horne Ballroom C

Speaker 4 of 6
* Stephen C. Blacklow, Harvard Medical School, USA
A Tail of Two Sites: Structural Basis for Recognition of Notch Ligands by Mind Bomb Proteins

Monday, February 03 | 8:00AM - 11:15AM
Signaling Mechanisms at the Cell Surface
Room: Van Horne Ballroom C

Speaker 3 of 6
William I. Weis, Stanford University, USA
Short Talk: Structural Basis of GSK-3 Regulation by Autoinhibition and by the Wnt Receptor LRP6

Monday, February 03 | 8:00AM - 11:15AM
Signaling Mechanisms at the Cell Surface
Room: Van Horne Ballroom C

Speaker 2 of 6
Xi He, Harvard Medical School, USA
Understanding the Mechanism of Wnt/beta-Catenin Signaling

Monday, February 03 | 8:00AM - 11:15AM
Signaling Mechanisms at the Cell Surface
Room: Van Horne Ballroom C

Speaker 1 of 6
Stefano Piccolo, University of Padua, Italy
Wnt Signaling through YAP and TAZ

Monday, February 03 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Monday, February 03 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Monday, February 03 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Monday, February 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Monday, February 03 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Monday, February 03 | 5:00PM - 7:00PM
Signaling Mechanisms and Cancer
Room: Van Horne Ballroom C

Speaker 4 of 4
Madelon M. Maurice, University Medical Center Utrecht, Netherlands
Short Talk: Cancer Mutations Derail Wnt Signalling via Conformational Conversion of the Scaffold Protein Axin

Monday, February 03 | 5:00PM - 7:00PM
Signaling Mechanisms and Cancer
Room: Van Horne Ballroom C

Speaker 3 of 4
* Warren S. Pear, University of Pennsylvania, USA
Targeting the Notch:Myc Axis in Cancer

Monday, February 03 | 5:00PM - 7:00PM
Signaling Mechanisms and Cancer
Room: Van Horne Ballroom C

Speaker 2 of 4
Holger Gerhardt, Max Delbrück Center for Molecular Medicine, Germany
Dll4/Notch Dynamics in Vascular Branching

Monday, February 03 | 5:00PM - 7:00PM
Signaling Mechanisms and Cancer
Room: Van Horne Ballroom C

Speaker 1 of 4
Adolfo Ferrando, Columbia University, USA
An Oncogenic Metabolic Switch Mediates Resistance to NOTCH1 Inhibition in T-ALL

Monday, February 03 | 5:00PM - 7:00PM
Shared Signals in Stem Cells and Cancer
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 1 of 5
* Thea D. Tlsty, University of California, San Francisco, USA


Monday, February 03 | 5:00PM - 7:00PM
Shared Signals in Stem Cells and Cancer
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 2 of 5
Philip A. Beachy, HHMI/Stanford University, USA
The Jekyll and Hyde Nature of Hedgehog Signaling in Cancer: Insights from the Urinary Bladder


Monday, February 03 | 5:00PM - 7:00PM
Shared Signals in Stem Cells and Cancer
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 3 of 5
Carman Man Chung Li, Massachusetts Institute of Technology, USA
Short Talk: The Roles of Pulmonary and Gastrointestinal Developmental Programs in Regulating Lung Cancer Metastasis


Monday, February 03 | 5:00PM - 7:00PM
Shared Signals in Stem Cells and Cancer
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 4 of 5
Tannishtha Reya, University of California, San Diego, USA
Developmental Pathways in Stem Cells and Cancer


Monday, February 03 | 5:00PM - 7:00PM
Shared Signals in Stem Cells and Cancer
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 5 of 5
Elaine V. Fuchs, Rockefeller University, USA
Signaling of Skin Stem Cells in Homeostasis and Cancer


Monday, February 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mezzanine 2


Monday, February 03 | 7:30PM - 10:00PM
Poster Session 1
Room: Mezzanine 2


Tuesday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Tuesday, February 04 | 8:00AM - 11:15AM
Nuclear Responses and Tumorigenesis
Room: Van Horne Ballroom C

Speaker 1 of 6
* Jon C. Aster, Brigham and Women's Hospital, USA
Determinants of Notch Target Gene Activation and Notch-“Addiction” in Cancer

Tuesday, February 04 | 8:00AM - 11:15AM
Nuclear Responses and Tumorigenesis
Room: Van Horne Ballroom C

Speaker 2 of 6
Raphael Kopan, University of Cincinnati College of Medicine, USA
Can We Record the Nuclear Footprints of Notch Signaling in Single Cells?

Tuesday, February 04 | 8:00AM - 11:15AM
Nuclear Responses and Tumorigenesis
Room: Van Horne Ballroom C

Speaker 3 of 6
Mariann Bienz, MRC Laboratory of Molecular Biology, UK
Nuclear Wnt Signaling

Tuesday, February 04 | 8:00AM - 11:15AM
Nuclear Responses and Tumorigenesis
Room: Van Horne Ballroom C

Speaker 4 of 6
Marian Waterman, University of California, Irvine, USA
A New Link Between Wnt, Warburg Metabolism, Stem Cells and Cancer

Tuesday, February 04 | 8:00AM - 11:15AM
Nuclear Responses and Tumorigenesis
Room: Van Horne Ballroom C

Speaker 5 of 6
Henner F. Farin, Hubrecht Institute, Netherlands
Short Talk: Wnt3 Gradient in Intestinal Epithelial Crypts Is Formed by Proliferative Dilution of Membrane-Associated Growth Factor

Tuesday, February 04 | 8:00AM - 11:15AM
Nuclear Responses and Tumorigenesis
Room: Van Horne Ballroom C

Speaker 6 of 6
Joseph Rosenbluh, Broad Institute, USA
Short Talk: Global Detailed Characterization of WNT Dependencies

Tuesday, February 04 | 8:00AM - 11:15AM
Cancer Cell of Origin
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 1 of 6
* John E. Dick, Princess Margaret Cancer Centre, Canada


Tuesday, February 04 | 8:00AM - 11:15AM
Cancer Cell of Origin
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 2 of 6
Robert J. Wechsler-Reya, Sanford-Burnham Medical Research Institute, USA
Stem Cells and the Origins of Medulloblastoma


Tuesday, February 04 | 8:00AM - 11:15AM
Cancer Cell of Origin
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 3 of 6
Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Genetic Mouse Models of Neural Cancer: Unique Insights and Translational Tools for Therapeutic Development


Tuesday, February 04 | 8:00AM - 11:15AM
Cancer Cell of Origin
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 4 of 6
Laetitia J. Seguin, University of California, San Diego, USA
Short Talk: beta3 Integrin/KRAS/RalB Complex Drives Tumor Stemness and Resistance to EGFR Inhibition


Tuesday, February 04 | 8:00AM - 11:15AM
Cancer Cell of Origin
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 5 of 6
Menno J. Oudhoff, Biomedical Research Centre, Canada
Short Talk: Set7 at the Intersection between Hippo/Yap and Wnt/beta-Catenin Signalling in Intestinal Homeostasis, Regeneration and Cancer


Tuesday, February 04 | 8:00AM - 11:15AM
Cancer Cell of Origin
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 6 of 6
Leonard I. Zon, HHMI/Boston Children's Hospital, USA
A Stem Cell Program Triggered at the Onset on Cancer


Tuesday, February 04 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Tuesday, February 04 | 11:15AM - 12:30PM
Roundtable: Preclinical Models and Early Translation
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 1 of 6
* Craig T. Jordan, University of Colorado, Anschutz Medical Campus, USA


Tuesday, February 04 | 11:15AM - 12:30PM
Roundtable: Preclinical Models and Early Translation
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 2 of 6
* Tannishtha Reya, University of California, San Diego, USA


Tuesday, February 04 | 11:15AM - 12:30PM
Roundtable: Preclinical Models and Early Translation
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 3 of 6
Robert S. Kerbel, Sunnybrook Research Institute, Canada
Recapitulating Postsurgical Adjuvant or Metastatic Therapy in Mice as a Strategy to Improve Predicting Clinical Outcomes


Tuesday, February 04 | 11:15AM - 12:30PM
Roundtable: Preclinical Models and Early Translation
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 4 of 6
Zena Werb, University of California, San Francisco, USA


Tuesday, February 04 | 11:15AM - 12:30PM
Roundtable: Preclinical Models and Early Translation
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 5 of 6
Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA


Tuesday, February 04 | 11:15AM - 12:30PM
Roundtable: Preclinical Models and Early Translation
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 6 of 6
David A. Cheresh, University of California, San Diego, USA


Tuesday, February 04 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Tuesday, February 04 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, February 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Tuesday, February 04 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, February 04 | 5:00PM - 7:15PM
Developmental Pathways and Tumor Initiation
Room: Van Horne Ballroom C

Speaker 1 of 4
* Freddy Radtke, EPFL SV ISREC UPRAD, Switzerland
Tumor Suppressive Roles of Notch in Epithelial Cells

Tuesday, February 04 | 5:00PM - 7:15PM
Developmental Pathways and Tumor Initiation
Room: Van Horne Ballroom C

Speaker 2 of 4
Owen J. Sansom, Beatson Institute of Cancer Research, UK
mTORC1 Is Required Following Apc Loss

Tuesday, February 04 | 5:00PM - 7:15PM
Developmental Pathways and Tumor Initiation
Room: Van Horne Ballroom C

Speaker 3 of 4
Rune C.M. Toftgard, Karolinska Institutet, Sweden
Hedgehog Signal Transduction and Cancer Initiation

Tuesday, February 04 | 5:00PM - 7:15PM
Developmental Pathways and Tumor Initiation
Room: Van Horne Ballroom C

Speaker 4 of 4
Philip H. Jones, Wellcome Trust Sanger Institute / University of Cambridge, UK
Short Talk: Inhibition of Notch Signaling Confers Clonal Dominance In Esophageal Epithelium

Tuesday, February 04 | 5:00PM - 7:00PM
Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 1 of 4
Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Hematopoietic Stem Cells Require a Highly Regulated Rate of Protein Synthesis


Tuesday, February 04 | 5:00PM - 7:00PM
Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 2 of 4
* John E. Dick, Princess Margaret Cancer Centre, Canada
Complex Mechanisms Underlie Intra-Tumoral Heterogeneity


Tuesday, February 04 | 5:00PM - 7:00PM
Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 3 of 4
Robert J. Vanner, Hospital for Sick Children, Canada
Short Talk: Quiescent Therapy Resistant Sox2+ Cells Drive Hierarchical Growth and Relapse in Shh-Subgroup Medulloblastoma


Tuesday, February 04 | 5:00PM - 7:00PM
Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 4 of 4
Jeffrey M. Rosen, Baylor College of Medicine, USA
Wnt and Fgf Signaling in Mammary Stem Cells and Breast Cancer


Tuesday, February 04 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Mezzanine 2


Tuesday, February 04 | 7:30PM - 10:00PM
Poster Session 2
Room: Mezzanine 2


Wednesday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Wednesday, February 05 | 8:00AM - 11:00AM
Stem Cells, Development and Cancer (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 7
* Tannishtha Reya, University of California, San Diego, USA

Wednesday, February 05 | 8:00AM - 11:00AM
Stem Cells, Development and Cancer (Joint)
Room: Van Horne Ballroom A/B

Speaker 2 of 7
* Frederic J. de Sauvage, Genentech, Inc., USA

Wednesday, February 05 | 8:00AM - 11:00AM
Stem Cells, Development and Cancer (Joint)
Room: Van Horne Ballroom A/B

Speaker 3 of 7
Cédric Blanpain, Universite Libre de Bruxelles, Belgium
Keynote Address: Developmental Pathways Regulating Stemness in Skin Cancers

Wednesday, February 05 | 8:00AM - 11:00AM
Stem Cells, Development and Cancer (Joint)
Room: Van Horne Ballroom A/B

Speaker 4 of 7
Roeland Nusse, HHMI/Stanford University, USA
Wnt Signaling and Stem Cell Control

Wednesday, February 05 | 8:00AM - 11:00AM
Stem Cells, Development and Cancer (Joint)
Room: Van Horne Ballroom A/B

Speaker 5 of 7
Ciara Metcalfe, Genentech, USA
Short Talk: Lgr5+ Stem Cells are Indispensible for Radiation-Induced Intestinal Regeneration

Wednesday, February 05 | 8:00AM - 11:00AM
Stem Cells, Development and Cancer (Joint)
Room: Van Horne Ballroom A/B

Speaker 6 of 7
Catriona H.M. Jamieson, University of California, San Diego, USA
The Niche Specific Role of RNA Editing in Leukemia Stem Cell Generation

Wednesday, February 05 | 8:00AM - 11:00AM
Stem Cells, Development and Cancer (Joint)
Room: Van Horne Ballroom A/B

Speaker 7 of 7
David A. Cheresh, University of California, San Diego, USA
Reversing Cancer Stemness and Drug Resistance

Wednesday, February 05 | 9:30AM - 9:50AM
Coffee Break
Room: Van Horne Foyer


Wednesday, February 05 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Wednesday, February 05 | 11:30AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Wednesday, February 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Wednesday, February 05 | 2:30PM - 4:30PM
Workshop
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 1 of 7
* Lauren I. R. Ehrlich, University of Texas at Austin, USA


Wednesday, February 05 | 2:30PM - 4:30PM
Workshop
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 2 of 7
Ho-Chou Tu, Children's Hospital Boston, USA
The Pluripotency Factor LIN28 Promotes Colorectal Tumorigenesis and Progression


Wednesday, February 05 | 2:30PM - 4:30PM
Workshop
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 3 of 7
Andrew C. White, Cornell University, USA
Stem Cell Quiescence Acts as a Tumor Suppressor Mechanism in Hair Follicle Initiated Squamous Tumors


Wednesday, February 05 | 2:30PM - 4:30PM
Workshop
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 4 of 7
Ching-Cheng Chen, City of Hope National Medical Center, USA
Acute Myeloid Leukemia-Derived Exosomes Transform Bone Marrow Niche into Leukemic Niche


Wednesday, February 05 | 2:30PM - 4:30PM
Workshop
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 5 of 7
Borhane Guezguez, McMaster Stem Cell and Cancer Research Institute, Canada
Modeling the Human Bone Marrow HSC Niche in vivo


Wednesday, February 05 | 2:30PM - 4:30PM
Workshop
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 6 of 7
Martin Lackmann, Monash University, Australia
Therapeutic Targeting of EphA3 in the Tumor Microenvironment Inhibits Cancer Growth


Wednesday, February 05 | 2:30PM - 4:30PM
Workshop
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 7 of 7
Gerald Schwank, ETH Zurich, Switzerland
Genome Editing by CRISPR/Cas9 in Intestinal Stem Cell Organoids


Wednesday, February 05 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, February 05 | 5:00PM - 7:00PM
Developmental Pathways in Cancer and Metastasis
Room: Van Horne Ballroom C

Speaker 1 of 4
* Michael D. Taylor, Hospital for Sick Children, Canada
Heterogeneity and Therapeutic Resistance Amongst the Shh Medulloblastomas

Wednesday, February 05 | 5:00PM - 7:00PM
Developmental Pathways in Cancer and Metastasis
Room: Van Horne Ballroom C

Speaker 2 of 4
Kimberly Stegmaier, Dana-Farber Cancer Institute, USA
Targeting Mutated NOTCH1 in Cancer

Wednesday, February 05 | 5:00PM - 7:00PM
Developmental Pathways in Cancer and Metastasis
Room: Van Horne Ballroom C

Speaker 3 of 4
Joerg Huelsken, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Targeting Tumor/Stroma Interactions to Overcome Metastasis

Wednesday, February 05 | 5:00PM - 7:00PM
Developmental Pathways in Cancer and Metastasis
Room: Van Horne Ballroom C

Speaker 4 of 4
Taran S. Gujral, Harvard Medical School, USA
Short Talk: Wnt5-Fzd2 Signaling Drives Epithelial-Mesenchymal Transition, Tumor Progression, and Metastasis

Wednesday, February 05 | 5:00PM - 7:15PM
Cancer in Context: The Microenvironment and Metastasis
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 1 of 6
* Jeffrey M. Rosen, Baylor College of Medicine, USA


Wednesday, February 05 | 5:00PM - 7:15PM
Cancer in Context: The Microenvironment and Metastasis
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 2 of 6
Zena Werb, University of California, San Francisco, USA
Imaging the Immune Microenvironment in Mammary Development and Cancer


Wednesday, February 05 | 5:00PM - 7:15PM
Cancer in Context: The Microenvironment and Metastasis
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 3 of 6
Lauren I. R. Ehrlich, University of Texas at Austin, USA
Short Talk: The Tumor Microenvironment Promotes Tumorigenesis in T-ALL


Wednesday, February 05 | 5:00PM - 7:15PM
Cancer in Context: The Microenvironment and Metastasis
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 4 of 6
Jing Yang, University of California, San Diego, USA
Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis


Wednesday, February 05 | 5:00PM - 7:15PM
Cancer in Context: The Microenvironment and Metastasis
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 5 of 6
Manuel Valiente, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Serpins Promote Cancer Cell Survival and Vascular Cooption in Brain Metastasis


Wednesday, February 05 | 5:00PM - 7:15PM
Cancer in Context: The Microenvironment and Metastasis
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 6 of 6
Carla F. Kim, Boston Children's Hospital, USA
Microenvironmental Regulation of Lung Stem Cell Differentiation


Wednesday, February 05 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Mezzanine 2


Wednesday, February 05 | 7:30PM - 10:00PM
Poster Session 3
Room: Mezzanine 2


Thursday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Thursday, February 06 | 8:00AM - 11:15AM
Emerging Cancer Drug Targets in Development Pathways
Room: Van Horne Ballroom C

Speaker 1 of 6
* Weilan Ye, Genentech, Inc., USA
The Norrin-Mediated Canonical Wnt Signaling Pathway Regulates Vascular Integrity



Thursday, February 06 | 8:00AM - 11:15AM
Emerging Cancer Drug Targets in Development Pathways
Room: Van Horne Ballroom C

Speaker 2 of 6
Feng Cong, Novartis Institutes for BioMedical Research, USA
Control of Wnt Signaling by Ubiquitin and Tankyrase

Thursday, February 06 | 8:00AM - 11:15AM
Emerging Cancer Drug Targets in Development Pathways
Room: Van Horne Ballroom C

Speaker 3 of 6
Babita Madan, DUKE-NUS Graduate Medical School, Singapore
Short Talk: Novel Porcn Inhibitors Are Safe and Effective in the Treatment of Wnt-Dependent Cancers

Thursday, February 06 | 8:00AM - 11:15AM
Emerging Cancer Drug Targets in Development Pathways
Room: Van Horne Ballroom C

Speaker 4 of 6
Bradley E. Bernstein, Massachusetts General Hospital, USA
Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-Like Cells

Thursday, February 06 | 8:00AM - 11:15AM
Emerging Cancer Drug Targets in Development Pathways
Room: Van Horne Ballroom C

Speaker 5 of 6
Austin Gurney, Napa Biotechnology Consulting, USA
Targeting Stem Cell Pathways in Cancer

Thursday, February 06 | 8:00AM - 11:15AM
Emerging Cancer Drug Targets in Development Pathways
Room: Van Horne Ballroom C

Speaker 6 of 6
Raoul C.D.S. Coombes, Imperial College London, UK
Short Talk: Antibodies to Nicastrin inhibit Invasion and Metastasis in Models of Breast Cancer

Thursday, February 06 | 8:00AM - 11:15AM
New Regulatory Pathways in Cancer
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 1 of 6
* Zena Werb, University of California, San Francisco, USA


Thursday, February 06 | 8:00AM - 11:15AM
New Regulatory Pathways in Cancer
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 2 of 6
Andreas Trumpp, German Cancer Research Center, Germany
Mesenchymal and MDS Stem Cells Shape an Interactive Disease Unit in the Bone Marrow


Thursday, February 06 | 8:00AM - 11:15AM
New Regulatory Pathways in Cancer
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 3 of 6
Lewis A. Chodosh, University of Pennsylvania School of Medicine, USA
Mechanisms Controlling Tumor Dormancy and Recurrence


Thursday, February 06 | 8:00AM - 11:15AM
New Regulatory Pathways in Cancer
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 4 of 6
Vishva M. Dixit, Genentech, Inc., USA
Apoptosis and Cancer


Thursday, February 06 | 8:00AM - 11:15AM
New Regulatory Pathways in Cancer
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 5 of 6
Robert MacLeod, Ionis Pharmaceuticals, Inc., USA
Short Talk: Preclinical and Early Clinical Evaluation of the Next Generation STAT3 Antisense Oligonucleotide STAT3rx/AZD9150


Thursday, February 06 | 8:00AM - 11:15AM
New Regulatory Pathways in Cancer
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 6 of 6
Daniel S. Pereira, Agensys, Inc, USA
Short Talk: AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody (MMAE) Drug Conjugate as a Potential Therapeutic for Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia


Thursday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Thursday, February 06 | 11:15AM - 12:15PM
Special Lecture: Keynote Address (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 1
Irving L. Weissman, Stanford University, USA
Reversing Cancer Stemness and Drug Resistance

Thursday, February 06 | 12:15PM - 5:00PM
On Own for Lunch and Recreation


Thursday, February 06 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, February 06 | 5:00PM - 7:00PM
Targeting Developmental Pathways: Clinical Experience
Room: Van Horne Ballroom C

Speaker 1 of 4
Gavin O. Thurston, Regeneron Pharmaceuticals Inc., USA
Blockade of Dll4-Notch Signaling in Tumor Angiogenesis

Thursday, February 06 | 5:00PM - 7:00PM
Targeting Developmental Pathways: Clinical Experience
Room: Van Horne Ballroom C

Speaker 2 of 4
Jean Y. Tang, Stanford University School of Medicine, USA
Hedgehog Pathway Inhibitor Clinical Trials

Thursday, February 06 | 5:00PM - 7:00PM
Targeting Developmental Pathways: Clinical Experience
Room: Van Horne Ballroom C

Speaker 3 of 4
* Frederic J. de Sauvage, Genentech, Inc., USA
Innate and Acquired Resistance to Hedgehog Pathways Inhibitors

Thursday, February 06 | 5:00PM - 7:00PM
Targeting Developmental Pathways: Clinical Experience
Room: Van Horne Ballroom C

Speaker 4 of 4
Lawrence Lum, University of Texas, Southwestern Medical Center, USA
Short Talk: Extra-Mitochondrial Bcl-2 Anti-Apoptotic Proteins Regulate Gli Transcriptional Activity

Thursday, February 06 | 5:00PM - 7:15PM
Targeting Cancer Stem Cells: Trials and Translation
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 1 of 6
* Vishva M. Dixit, Genentech, Inc., USA


Thursday, February 06 | 5:00PM - 7:15PM
Targeting Cancer Stem Cells: Trials and Translation
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 2 of 6
Craig T. Jordan, University of Colorado, Anschutz Medical Campus, USA
Targeting Metabolic Properties to More Effectively Eradicate Leukemia Stem Cells


Thursday, February 06 | 5:00PM - 7:15PM
Targeting Cancer Stem Cells: Trials and Translation
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 3 of 6
Annette Friebe, Nexigen GmbH, Germany
Short Talk: Drugging the Undruggables - Cell-Permeable Peptide Antagonists Targeting the Wnt Signaling Pathway


Thursday, February 06 | 5:00PM - 7:15PM
Targeting Cancer Stem Cells: Trials and Translation
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 4 of 6
Peter Chu, Eclipse BioInnovations, USA
Short Talk: Therapeutic Targeting of Cancer Stem Cells with BNC101, a Functional Anti-LGR5 Monoclonal Antibody


Thursday, February 06 | 5:00PM - 7:15PM
Targeting Cancer Stem Cells: Trials and Translation
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 5 of 6
Jeremy Naftali Rich, Cleveland Clinic, USA
Partners in Crime: Tumor Stem Cells and the Tumor Microenvironment


Thursday, February 06 | 5:00PM - 7:15PM
Targeting Cancer Stem Cells: Trials and Translation
This session is from Stem Cells and Cancer
Room: Van Horne Ballroom A/B

Speaker 6 of 6
Michael F. Clarke, Stanford University, USA
Regulation of Normal and Cancer Stem Cell Self Renewal and Senescence by USP16


Thursday, February 06 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Mezzanine 2


Thursday, February 06 | 8:00PM - 11:00PM
Entertainment
Room: Mezzanine 2


Thursday, February 06 | 8:15PM - 11:00PM
Cash Bar
Room: Mezzanine 2


Friday, February 07 | 10:25AM - 10:25AM
Departure


*Session Chair.