Web Desc
Cancer Epigenetics
joint with Transcriptional Regulation
Organizer(s): Sharon Y.R. Dent, Jean-Pierre Issa and Peter A. Jones
Date: February 04 - 09, 2014
Location: Santa Fe Community Convention Center, Santa Fe, NM, USA
Sponsored by Astellas Pharma Inc., Celgene Corporation, Constellation Pharmaceuticals and Novartis Institutes for BioMedical Research
For important information on the coronavirus, please click here
Summary of Meeting:
Epigenetic changes are now recognized to be as important to cancer formation as are gene mutations. Unlike mutations, however, epigenetic states can be altered, and epigenetic therapies hold promise as anti-cancer agents. For these approaches to succeed, we must understand how epigenetic states are created and maintained, and how they are altered in particular malignancies. This meeting will highlight large scale epigenome mapping efforts in normal cells, stem cells, and cancer cells, as well as genetic and biochemical studies focused on defining the mechanistic underpinning of these states. The meeting will bring together basic scientists studying the enzymes that govern epigenetic marks, particularly DNA methylation and histone post translational modifications, with translational and clinical researchers who are developing and implementing new epigenetic therapies. Opportunities for cross fertilization of ideas and interdisciplinary interactions will be further strengthened by joint keynote and plenary sessions with the concurrent meeting on Transcriptional Regulation.
Scholarship Deadline: October 15 2013
Discounted Abstract Deadline: October 15 2013
Abstract Deadline: November 7 2013
Discounted Registration Deadline: December 4 2013
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Astellas Pharma Inc.Celgene CorporationConstellation PharmaceuticalsNovartis Institutes for BioMedical Research
We gratefully acknowledge additional support for this conference from:
Abcam plcCayman Chemical CompanyCell Signaling Technology, Inc.InventivaLandes BioscienceZymo Research Corporation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA181881-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 04 | 4:00PM - 8:00PM
Arrival and Registration
Room: Sweeney Ballroom Foyer


Wednesday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Wednesday, February 05 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 2
* Sharon Y.R. Dent, University of Texas MD Anderson Cancer Center, USA

Wednesday, February 05 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 2
James E. Bradner, Novartis Institutes for BioMedical Research, USA
Chemical Modulation of Chromatin Structure and Function

Wednesday, February 05 | 9:00AM - 11:45AM
Fundamentals at the Structural, Biochemical and Genomic Leve
ls (Joint)

Room: Sweeney Ballroom A-E

Speaker 1 of 5
* Sharon Y.R. Dent, University of Texas MD Anderson Cancer Center, USA

Wednesday, February 05 | 9:00AM - 11:45AM
Fundamentals at the Structural, Biochemical and Genomic Leve
ls (Joint)

Room: Sweeney Ballroom A-E

Speaker 2 of 5
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Cellular Metabolism and Epigenetic Changes in Cancer

Wednesday, February 05 | 9:00AM - 11:45AM
Fundamentals at the Structural, Biochemical and Genomic Leve
ls (Joint)

Room: Sweeney Ballroom A-E

Speaker 3 of 5
Joan W. Conaway, Stowers Institute for Medical Research, USA
Function and Regulation of the Human INO80 Complex

Wednesday, February 05 | 9:00AM - 11:45AM
Fundamentals at the Structural, Biochemical and Genomic Leve
ls (Joint)

Room: Sweeney Ballroom A-E

Speaker 4 of 5
Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany
Transcriptome Surveillance by Selective Termination of Non-Coding RNA Synthesis

Wednesday, February 05 | 9:00AM - 11:45AM
Fundamentals at the Structural, Biochemical and Genomic Leve
ls (Joint)

Room: Sweeney Ballroom A-E

Speaker 5 of 5
Bing Ren, Ludwig Institute for Cancer Research, USA
Long-Range Control Sequences in Health and Diseases

Wednesday, February 05 | 9:40AM - 10:00AM
Coffee Break
Room: Sweeney F, Main Level Breakouts


Wednesday, February 05 | 11:45AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakouts


Wednesday, February 05 | 11:45AM - 5:00PM
On Own for Lunch and Recreation


Wednesday, February 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakouts


Wednesday, February 05 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakouts


Wednesday, February 05 | 5:00PM - 7:15PM
Genomic Profiles of Chromatin Modifiers in Cancer
Room: Sweeney Ballroom A-B

Speaker 1 of 6
* Peter A. Jones, Van Andel Research Institute, USA

Wednesday, February 05 | 5:00PM - 7:15PM
Genomic Profiles of Chromatin Modifiers in Cancer
Room: Sweeney Ballroom A-B

Speaker 2 of 6
Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA
The Functional Relevance of JARID1B in Breast Cancer

Wednesday, February 05 | 5:00PM - 7:15PM
Genomic Profiles of Chromatin Modifiers in Cancer
Room: Sweeney Ballroom A-B

Speaker 3 of 6
Peggy J. Farnham, University of Southern California, USA
Using Epigenetic Drugs and Genome Engineering to Target Cancer-Associated Enhancers

Wednesday, February 05 | 5:00PM - 7:15PM
Genomic Profiles of Chromatin Modifiers in Cancer
Room: Sweeney Ballroom A-B

Speaker 4 of 6
Dirk Schübeler, Friedrich Miescher Institute for Biomedical Research, Switzerland
Genomic Patterns and Context Specific Interpretation of DNA Methylation

Wednesday, February 05 | 5:00PM - 7:15PM
Genomic Profiles of Chromatin Modifiers in Cancer
Room: Sweeney Ballroom A-B

Speaker 5 of 6
Dan A. Landau, Dana-Farber Cancer Institute and the Broad Institute, USA
Short Talk: Locally Disordered DNA Methylation Forms the Basis of Intra-Leukemic Epigenetic Heterogeneity and Enhances CLL Evolution

Wednesday, February 05 | 5:00PM - 7:15PM
Genomic Profiles of Chromatin Modifiers in Cancer
Room: Sweeney Ballroom A-B

Speaker 6 of 6
James J. Morrow, Case Western Reserve University School of Medicine, USA
Short Talk: Specific Alterations in the Enhancer Epigenome Drive a Unique Transcriptional Program to Mediate the Metastatic Phenotype in Osteosarcoma

Wednesday, February 05 | 5:00PM - 7:15PM
Transcription Factors and Cofactors
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Richard A. Young, Whitehead Institute for Biomedical Research, USA


Wednesday, February 05 | 5:00PM - 7:15PM
Transcription Factors and Cofactors
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Robert G. Roeder, Rockefeller University, USA
Transcriptional Coactivators: Recruitment Mechanisms and Functions


Wednesday, February 05 | 5:00PM - 7:15PM
Transcription Factors and Cofactors
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 3 of 5
Martha L. Bulyk, Brigham & Women's Hospital and Harvard Medical School, USA
The Genomic Landscape of NF-kB Binding in Lymphoblastoid B-Cells


Wednesday, February 05 | 5:00PM - 7:15PM
Transcription Factors and Cofactors
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Eva Nogales, University of California, Berkeley, USA
Structure of the Human Transcription Preinitiation Complex


Wednesday, February 05 | 5:00PM - 7:15PM
Transcription Factors and Cofactors
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 5 of 5
David H. Price, University of Iowa, USA
Functional Domains of Gdown1 and Regulation by Phosphorylation


Wednesday, February 05 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts


Wednesday, February 05 | 7:30PM - 10:00PM
Poster Session 1
Room: Sweeney F, Main Level Breakouts


Thursday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Thursday, February 06 | 7:30AM - 8:00AM
Poster Setup
Room: Sweeney F, Main Level Breakouts


Thursday, February 06 | 8:00AM - 7:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakouts


Thursday, February 06 | 8:00AM - 11:00AM
Histone Modifiers in Development and Cancer
Room: Sweeney Ballroom A-B

Speaker 1 of 6
* Mark T. Bedford, University of Texas MD Anderson Cancer Center, USA

Thursday, February 06 | 8:00AM - 11:00AM
Histone Modifiers in Development and Cancer
Room: Sweeney Ballroom A-B

Speaker 2 of 6
Robert A. Waterland, Baylor College of Medicine, USA
Early Nutritional Influences on Human Metastable Epialleles

Thursday, February 06 | 8:00AM - 11:00AM
Histone Modifiers in Development and Cancer
Room: Sweeney Ballroom A-B

Speaker 3 of 6
Sharon Y.R. Dent, University of Texas MD Anderson Cancer Center, USA
A SAGA of GCN5 and USP22 in Development and Disease

Thursday, February 06 | 8:00AM - 11:00AM
Histone Modifiers in Development and Cancer
Room: Sweeney Ballroom A-B

Speaker 4 of 6
Yi Zhang, HHMI/Harvard Medical School, Children's Hospital Boston, USA
Mechanism and Function of Tet-Mediated 5mC Oxidation


Thursday, February 06 | 8:00AM - 11:00AM
Histone Modifiers in Development and Cancer
Room: Sweeney Ballroom A-B

Speaker 5 of 6
Sung Hee Baek, Seoul National University, South Korea
Histone Modifiers in Epigenetic Control of Stem Cell Homeostasis and Cancer

Thursday, February 06 | 8:00AM - 11:00AM
Histone Modifiers in Development and Cancer
Room: Sweeney Ballroom A-B

Speaker 6 of 6
Andy J. Andrews, Fox Chase Cancer Center, USA
Short Talk: Herding KATs: How Acetyl-CoA and Small Molecules Can Alter Selectivity of CBP and p300

Thursday, February 06 | 8:00AM - 11:00AM
Transcriptional Control in Development
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 1 of 6
* Robert G. Roeder, Rockefeller University, USA


Thursday, February 06 | 8:00AM - 11:00AM
Transcriptional Control in Development
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 2 of 6
Michael S. Levine, Princeton University, USA
Pause Control in Development


Thursday, February 06 | 8:00AM - 11:00AM
Transcriptional Control in Development
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 3 of 6
Karen Adelman, Harvard Medical School, USA
RNA Polymerase II Pausing in Pluripotent Stem Cells


Thursday, February 06 | 8:00AM - 11:00AM
Transcriptional Control in Development
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 4 of 6
Joanna Wysocka, Stanford University, USA
Mechanisms of Developmental Plasticity


Thursday, February 06 | 8:00AM - 11:00AM
Transcriptional Control in Development
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 5 of 6
Margaret T. Fuller, Stanford University, USA
Cell Type Specific Transcriptional Repression Programs Proper Differentiation a Stem Cell Lineage


Thursday, February 06 | 8:00AM - 11:00AM
Transcriptional Control in Development
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 6 of 6
Artem Barski, Cincinnati Children's Hospital, USA
Short Talk: Rapid Recall Ability of Memory T Cells Is Encoded in their Epigenome


Thursday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakouts


Thursday, February 06 | 11:00AM - 12:00PM
Lunch
Room: Sweeney F, Main Level Breakouts


Thursday, February 06 | 12:00PM - 2:30PM
Poster Session 2
Room: Sweeney F, Main Level Breakouts


Thursday, February 06 | 2:30PM - 3:00PM
Coffee Available
Room: Sweeney F, Main Level Breakouts


Thursday, February 06 | 3:00PM - 5:00PM
Genetic and Epigenetic Interactions in Cancer
Room: Sweeney Ballroom A-B

Speaker 1 of 5
* Margaret A. Goodell, Baylor College of Medicine, USA

Thursday, February 06 | 3:00PM - 5:00PM
Genetic and Epigenetic Interactions in Cancer
Room: Sweeney Ballroom A-B

Speaker 2 of 5
Susan J. Clark, Garvan Institute of Medical Research, Australia
CpG Island Methylation in Cancer: What Is the
Trigger?


Thursday, February 06 | 3:00PM - 5:00PM
Genetic and Epigenetic Interactions in Cancer
Room: Sweeney Ballroom A-B

Speaker 3 of 5
Megan P. Hitchins, Stanford University School of Medicine, USA
Epimutations and Epialleles in Familial Cancer

Thursday, February 06 | 3:00PM - 5:00PM
Genetic and Epigenetic Interactions in Cancer
Room: Sweeney Ballroom A-B

Speaker 4 of 5
Xiaobing Shi, Van Andel Institute, USA
Short Talk: Histone Variant H3.3-Specific Readout of H3K36 Trimethylation by ZMYND11

Thursday, February 06 | 3:00PM - 5:00PM
Genetic and Epigenetic Interactions in Cancer
Room: Sweeney Ballroom A-B

Speaker 5 of 5
Ki Eun Pyo, Seoul National University, South Korea
Short Talk: EZH2 Generates a Methyl Degron that Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex

Thursday, February 06 | 3:00PM - 5:00PM
ncRNAs
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Karen Adelman, Harvard Medical School, USA


Thursday, February 06 | 3:00PM - 5:00PM
ncRNAs
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs


Thursday, February 06 | 3:00PM - 5:00PM
ncRNAs
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 3 of 5
John L. Rinn, University of Colorado Boulder, USA
Linking RNA to Nuclear Architecture


Thursday, February 06 | 3:00PM - 5:00PM
ncRNAs
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Christopher K. Glass, University of California, San Diego, USA
Enhancer RNAs: Noise, Consequence or Contributors to Enhancer Function?


Thursday, February 06 | 3:00PM - 5:00PM
ncRNAs
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Michael Jordan Rowley, University of Michigan, USA
Short Talk: Gene Expression and Heterochromatin Edge Control via Transcriptional Gene Silencing


Thursday, February 06 | 5:00PM - 5:00PM
On Own for Dinner


Friday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Friday, February 07 | 8:00AM - 11:00AM
Aging, Epigenetic Variation and Cancer
Room: Sweeney Ballroom A-B

Speaker 1 of 6
* Robert A. Waterland, Baylor College of Medicine, USA

Friday, February 07 | 8:00AM - 11:00AM
Aging, Epigenetic Variation and Cancer
Room: Sweeney Ballroom A-B

Speaker 2 of 6
Jean-Pierre Issa, Temple University School of Medicine, USA
Epigenetic Drift in Aging and Cancer

Friday, February 07 | 8:00AM - 11:00AM
Aging, Epigenetic Variation and Cancer
Room: Sweeney Ballroom A-B

Speaker 3 of 6
Margaret A. Goodell, Baylor College of Medicine, USA
DNA Methylation in Normal and Malignant Hematopoiesis

Friday, February 07 | 8:00AM - 11:00AM
Aging, Epigenetic Variation and Cancer
Room: Sweeney Ballroom A-B

Speaker 4 of 6
Taiping Chen, University of Texas MD Anderson Cancer Center, USA
Crosstalk between DNA Methylation and Histone Methylation in Mammalian Development and Disease

Friday, February 07 | 8:00AM - 11:00AM
Aging, Epigenetic Variation and Cancer
Room: Sweeney Ballroom A-B

Speaker 5 of 6
Johnathan R. Whetstine, Fox Chase Cancer Center, USA
Chromatin Modulators Provide a New Insight into Cancer Genomes

Friday, February 07 | 8:00AM - 11:00AM
Aging, Epigenetic Variation and Cancer
Room: Sweeney Ballroom A-B

Speaker 6 of 6
Brian C. Capell, University of Pennsylvania, USA
Short Talk: Senescence Leads to Epigenomic Disruption Invoking Hallmarks of Reprogramming and Pluripotency

Friday, February 07 | 8:00AM - 11:00AM
Transcription, Development and Disease
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 1 of 6
* Joanna Wysocka, Stanford University, USA


Friday, February 07 | 8:00AM - 11:00AM
Transcription, Development and Disease
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 2 of 6
Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Transcription Elongation in Blood Development and Cancer


Friday, February 07 | 8:00AM - 11:00AM
Transcription, Development and Disease
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 3 of 6
Joaquín M. Espinosa, Linda Crnic Institute for Down Syndrome, USA
Mechanisms of Transcriptional Regulation in the p53 Network


Friday, February 07 | 8:00AM - 11:00AM
Transcription, Development and Disease
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 4 of 6
Kenneth S. Zaret, University of Pennsylvania, USA
Regulatory Mechanisms in Mammalian Tissue Induction and Cell Reprogramming


Friday, February 07 | 8:00AM - 11:00AM
Transcription, Development and Disease
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 5 of 6
Thomas G. Boyer, University of Texas Health Science Center at San Antonio, USA
Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity


Friday, February 07 | 8:00AM - 11:00AM
Transcription, Development and Disease
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 6 of 6
Michael L. Stitzel, The Jackson Laboratory for Genomic Medicine, USA
Short Talk: Stretch Enhancers, Cell Identity and GWAS


Friday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakouts


Friday, February 07 | 11:00AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakouts


Friday, February 07 | 11:00AM - 2:30PM
On Own for Lunch and Recreation


Friday, February 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakouts


Friday, February 07 | 2:30PM - 4:30PM
Workshop: Current Topics in Epigenetics

Speaker 1 of 7
* Johnathan R. Whetstine, Fox Chase Cancer Center, USA

Friday, February 07 | 2:30PM - 4:30PM
Workshop: Current Topics in Epigenetics

Speaker 2 of 7
Calley L. Hirsch, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Canada
Characterizing the Earliest Epigenetic Events in Reprogramming

Friday, February 07 | 2:30PM - 4:30PM
Workshop: Current Topics in Epigenetics

Speaker 3 of 7
Alessia Cavazza, Dana Farber Cancer Institute, Harvard Medical School, USA
CNOT3 Regulates an Embryonic Stem Cell-Like Self-Renewal Pathway in Colorectal Cancer

Friday, February 07 | 2:30PM - 4:30PM
Workshop: Current Topics in Epigenetics

Speaker 4 of 7
Collene R. Jeter, University of Texas MD Anderson Medical Center, USA
NANOG Regulation of Prostate Tumorigenesis

Friday, February 07 | 2:30PM - 4:30PM
Workshop: Current Topics in Epigenetics

Speaker 5 of 7
Gregory David, New York University School of Medicine, USA
An Epigenetic Program Required for Oncogene-Induced Senescence Drives Inflammation and Pancreatic Cancer Progression

Friday, February 07 | 2:30PM - 4:30PM
Workshop: Current Topics in Epigenetics

Speaker 6 of 7
Wa Zhang, University of Nebraska Medical Center, USA
The Molecular Pathology of DNA Hypomethylation in Epithelial Ovarian Cancer (EOC)

Friday, February 07 | 2:30PM - 4:30PM
Workshop: Current Topics in Epigenetics

Speaker 7 of 7
Daniel Thomas, Stanford University, USA
Wilms' Tumor 1 Mutation is a Driver of DNA Hyper-Methylation in Acute Myeloid Leukemia

Friday, February 07 | 2:30PM - 4:30PM
Workshop: Transcriptional Regulation
This session is from Transcriptional Regulation

Speaker 1 of 9
* Michael S. Levine, Princeton University, USA


Friday, February 07 | 2:30PM - 4:30PM
Workshop: Transcriptional Regulation
This session is from Transcriptional Regulation

Speaker 2 of 9
Benjamin R. Sabari, University of Texas Southwestern Medical Center, USA
Metabolic Regulation of Transcription through Differential Histone Acylations


Friday, February 07 | 2:30PM - 4:30PM
Workshop: Transcriptional Regulation
This session is from Transcriptional Regulation

Speaker 3 of 9
Elizabeth M. Duncan, Stowers Institute for Medical Research, USA
Set1 Regulates Genes Required for Stem Cell Function in Schmidtea mediterranea


Friday, February 07 | 2:30PM - 4:30PM
Workshop: Transcriptional Regulation
This session is from Transcriptional Regulation

Speaker 4 of 9
Alessandro Gardini, Wistar Institute, USA
Integrator Regulates Transcriptional Pausing and Elongation at Immediate Early Genes


Friday, February 07 | 2:30PM - 4:30PM
Workshop: Transcriptional Regulation
This session is from Transcriptional Regulation

Speaker 5 of 9
Matthias Merkenschlager, Imperial College London, UK
Features of Cohesin-Mediated Gene Regulation


Friday, February 07 | 2:30PM - 4:30PM
Workshop: Transcriptional Regulation
This session is from Transcriptional Regulation

Speaker 6 of 9
Jian Yan, Karolinska Institutet, Sweden
Inheritance of the Transcriptional Regulatory Landscape in Human Cells


Friday, February 07 | 2:30PM - 4:30PM
Workshop: Transcriptional Regulation
This session is from Transcriptional Regulation

Speaker 7 of 9
Andrew Xiao, Yale University, USA
A Novel Epigenetic Pathway Regulating ES Heterogeneity


Friday, February 07 | 2:30PM - 4:30PM
Workshop: Transcriptional Regulation
This session is from Transcriptional Regulation

Speaker 8 of 9
Lorenzo Pasquali, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Spain
Pancreatic Islet Epigenomics Reveals Enhancer Clusters that Are Enriched in Type 2 Diabetes


Friday, February 07 | 2:30PM - 4:30PM
Workshop: Transcriptional Regulation
This session is from Transcriptional Regulation

Speaker 9 of 9
Kai Ge, NIDDK, National Institutes of Health, USA
Enhancer Regulation by H3K4me1/2 Methyltransferase MLL4


Friday, February 07 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakouts


Friday, February 07 | 5:00PM - 7:00PM
Therapeutics Discovery (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 5
* Jean-Pierre Issa, Temple University School of Medicine, USA

Friday, February 07 | 5:00PM - 7:00PM
Therapeutics Discovery (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 5
Mark T. Bedford, University of Texas MD Anderson Cancer Center, USA
Defining New Histone Reader Domains

Friday, February 07 | 5:00PM - 7:00PM
Therapeutics Discovery (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 5
Peter A. Jones, Van Andel Research Institute, USA
Targeting Chromatin for Therapy

Friday, February 07 | 5:00PM - 7:00PM
Therapeutics Discovery (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 5
Yali Dou, University of Michigan, USA
Targeting H3 K4 Methylation by MLL1 in Treatment of Mixed Lineage Leukemia

Friday, February 07 | 5:00PM - 7:00PM
Therapeutics Discovery (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 5
Rui Li, University of Texas Southwestern Medical Center, USA
Short Talk: Suppression of Estrogen-Induced Gene Expression in Breast Cancer Cells by the BET Inhibitor JQ1

Friday, February 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts


Friday, February 07 | 7:30PM - 10:00PM
Poster Session 3
Room: Sweeney F, Main Level Breakouts


Saturday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Saturday, February 08 | 8:00AM - 11:00AM
Programming and Reprogramming (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 5
* Kenneth S. Zaret, University of Pennsylvania, USA

Saturday, February 08 | 8:00AM - 11:00AM
Programming and Reprogramming (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 5
Amanda G. Fisher, Imperial College London, UK
Human X Chromosome Reactivation by Cell Fusion Reprogramming

Saturday, February 08 | 8:00AM - 11:00AM
Programming and Reprogramming (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 5
Chris J.C. van Oevelen, Centre for Genomic Regulation, Spain
C/EBPa Orchestrates the Activity of Distinct Enhancer Types during Transdifferentiation

Saturday, February 08 | 8:00AM - 11:00AM
Programming and Reprogramming (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 5
Jacob H. Hanna, Weizmann Institute of Science, Israel
Molecular Mechanisms for Inducing and Maintaining Pluripotent States

Saturday, February 08 | 8:00AM - 11:00AM
Programming and Reprogramming (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 5
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Roles for Transcriptional Super-Enhancers in Cell Identity and Disease

Saturday, February 08 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakouts


Saturday, February 08 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Saturday, February 08 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakouts


Saturday, February 08 | 5:00PM - 7:00PM
Epigenetic Therapies
Room: Sweeney Ballroom A-B

Speaker 1 of 5
* Susan J. Clark, Garvan Institute of Medical Research, Australia

Saturday, February 08 | 5:00PM - 7:00PM
Epigenetic Therapies
Room: Sweeney Ballroom A-B

Speaker 2 of 5
Stephen B. Baylin, Johns Hopkins University School of Medicine, USA
Role of Epigenetics in Cancer Treatments

Saturday, February 08 | 5:00PM - 7:00PM
Epigenetic Therapies
Room: Sweeney Ballroom A-B

Speaker 3 of 5
Caretha L. Creasy, GlaxoSmithKline Pharmaceuticals, USA
Therapeutic Opportunities for EZH2 Methyltransferase Inhibitors in Lymphoma

Saturday, February 08 | 5:00PM - 7:00PM
Epigenetic Therapies
Room: Sweeney Ballroom A-B

Speaker 4 of 5
Kenneth P. Nephew, Indiana University, USA
Epigenetic Therapies that Overcome Cancer Drug Resistance

Saturday, February 08 | 5:00PM - 7:00PM
Epigenetic Therapies
Room: Sweeney Ballroom A-B

Speaker 5 of 5
Michael P. Kladde, University of Florida, USA
Short Talk: Epigenetic Profiling Identifies Drug-Tolerant Glioblastoma Cells

Saturday, February 08 | 5:00PM - 7:00PM
Cellular and Global Views of Transcription
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 1 of 5
* Bing Ren, Ludwig Institute for Cancer Research, USA


Saturday, February 08 | 5:00PM - 7:00PM
Cellular and Global Views of Transcription
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 2 of 5
Job Dekker, University of Massachusetts Medical School, USA
Chromosome Folding and Gene Regulation


Saturday, February 08 | 5:00PM - 7:00PM
Cellular and Global Views of Transcription
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 3 of 5
B. Franklin Pugh, Pennsylvania State University, USA
Genome-Wide Organization of Chromatin and the Transcription Machinery


Saturday, February 08 | 5:00PM - 7:00PM
Cellular and Global Views of Transcription
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 4 of 5
Michael P. Snyder, Stanford University School of Medicine, USA
Analysis of Regulatory Networks within and between Species


Saturday, February 08 | 5:00PM - 7:00PM
Cellular and Global Views of Transcription
This session is from Transcriptional Regulation
Room: Sweeney Ballroom C-E

Speaker 5 of 5
Frédéric L. Chedin, University of California, Davis, USA
Short Talk: Transcription Protects CpG Island Promoters from DNA Methylation Independently of Histone H3 lysine 4 Trimethylation


Saturday, February 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts


Saturday, February 08 | 8:00PM - 11:00PM
Entertainment
Room: Sweeney F, Main Level Breakouts


Saturday, February 08 | 8:00PM - 11:00PM
Cash Bar
Room: Sweeney F, Main Level Breakouts


Sunday, February 09 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.