Web Desc
Prophylactic and Therapeutic Antibodies
joint with Biology of B Cell Responses
Organizer(s): Margaret Karow and Neil Stahl
Date: February 09 - 14, 2014
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc. and Roche. Supported by an educational grant from Lilly.
Summary of Meeting:
Until recently, most antibody therapeutics have been indicated for inflammatory diseases and cancer. The success of this approach has led to an expansion to a broader group of diseases such as infection, metabolic diseases, pain, Alzheimer’s and bone diseases, bringing a new level of challenge. This meeting will address developing antibodies for prophylactic- or chronic-use indications that have traditionally been dominated by small-molecule therapeutics, with case studies describing the development of antibodies for these marketplaces. It will also explore how molecule choices, dosing and delivery, and clinical design for efficacy and the minimization of safety risk, all impact success. The meeting will address up-and-coming approaches such as antibody engineering for pharmacokinetic and pharmacodynamic improvements, the use of vaccines to induce humoral responses in vivo, and use of antibodies to deliver vaccines, as well as look back at what has been learned from chronic therapy of immune diseases. We expect the attendees will be from the fields of translational medicine, antibody generation, pre-clinical pharmacology and clinical testing, whose work contributes to and drives innovation in these fields. It is anticipated that they will come away with an appreciation of these challenges and that the meeting will stimulate research and novel solutions for addressing this group of indications. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on “Biology of B Cell Responses,” which will share a plenary session on antibody diversity.
Scholarship Deadline: October 16 2013
Discounted Abstract Deadline: October 16 2013
Abstract Deadline: November 14 2013
Discounted Registration Deadline: December 10 2013
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Boehringer Ingelheim Pharmaceuticals, Inc.Educational grant from LillyRoche
We gratefully acknowledge additional support for this conference from:
MedImmune
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Alexion Pharmaceuticals, Inc.

Biogen Idec

MedImmune
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI109807-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 09 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Monday, February 10 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Monday, February 10 | 8:00AM - 9:15AM
Welcome and Keynote Address
Room: Quandary Peak

Speaker 1 of 2
* Margaret Karow, Akrevia Therapeutics, USA
Introductory Remarks

Monday, February 10 | 8:00AM - 9:15AM
Welcome and Keynote Address
Room: Quandary Peak

Speaker 2 of 2
Joseph Miletich, Merck, USA
Antibody Therapeutic Indications: Expanding Beyond Cancer and Inflammatory Diseases

Monday, February 10 | 9:00AM - 11:35AM
Programming B Cell Physiology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 5
Barry P. Sleckman, University of Alabama Birmingham School of Medicine, USA
Regulation of B Cell Development by Signals from RAG-Mediated DNA Double Strand Breaks


Monday, February 10 | 9:00AM - 11:35AM
Programming B Cell Physiology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 5
Cornelis Murre, University of California, San Diego, USA
Global Analysis of Long-Range Genomic Interactions that Orchestrate Lymphocyte Cell Fate


Monday, February 10 | 9:00AM - 11:35AM
Programming B Cell Physiology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 5
Hassan Jumaa, Institute for Immunology, Ulm University Hospital, Germany
Pre B Cell Development


Monday, February 10 | 9:00AM - 11:35AM
Programming B Cell Physiology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 5
* Stephen L. Nutt, Walter and Eliza Hall Institute, Australia
Short Talk: The Intrinsic and Extrinsic Controls of Late B Cell Differentiation


Monday, February 10 | 9:00AM - 11:35AM
Programming B Cell Physiology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 5 of 5
Amy L. Kenter, University of Illinois College of Medicine, USA
Short Talk: Class Switch Recombination can Precede V(D)J Joining during Early B Cell Development: Consequences and Implications in vivo


Monday, February 10 | 9:15AM - 11:30AM
Novel Antibody Therapy for Pain
Room: Quandary Peak

Speaker 1 of 4
* Margaret Karow, Akrevia Therapeutics, USA

Monday, February 10 | 9:15AM - 11:30AM
Novel Antibody Therapy for Pain
Room: Quandary Peak

Speaker 2 of 4
Mark T. Brown, Pfizer, USA
Overview of Analgesic Efficacy and Safety of Tanezumab, a Monoclonal Antibody Targeting Nerve Growth Factor for Treatment of Chronic Pain

Monday, February 10 | 9:15AM - 11:30AM
Novel Antibody Therapy for Pain
Room: Quandary Peak

Speaker 3 of 4
John A. Latham, Alder BioPharmaceuticals, USA
The Discovery and Development of an Anti-CGRP Antibody ALD403 for the Treatment of Migraine

Monday, February 10 | 9:15AM - 11:30AM
Novel Antibody Therapy for Pain
Room: Quandary Peak

Speaker 4 of 4
Stephen P. Squinto, OrbiMed Healthcare Fund Management, USA
Development of a Terminal Complement Inhibitor for the Treatment of Life-Threatening Ultra Rare Chronic Diseases

Monday, February 10 | 9:40AM - 10:00AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 10 | 11:30AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Monday, February 10 | 11:30AM - 2:00PM
On Own for Lunch and Recreation


Monday, February 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Monday, February 10 | 2:00PM - 4:30PM
Workshop 1: Crossing the Blood-Brain Barrier
Room: Quandary Peak

Speaker 1 of 5
Jean E. Lachowicz, Angiochem, Canada
Creation of a Brain-Penetrant Peptide-Antibody Conjugate that Targets Brain Tumors and Increases Survival in Mice with Intracranial HER2+ Tumors

Monday, February 10 | 2:00PM - 4:30PM
Workshop 1: Crossing the Blood-Brain Barrier
Room: Quandary Peak

Speaker 2 of 5
* Robert G. Thorne, Denali Therapeutics, USA
Bypassing the Blood-Brain Barrier to Directly Deliver Antibodies and Antibody Fragments
to Central Nervous System Target Sites


Monday, February 10 | 2:00PM - 4:30PM
Workshop 1: Crossing the Blood-Brain Barrier
Room: Quandary Peak

Speaker 3 of 5
Denise D. Karaoglu, AbbVie Bioresearch Center, USA
Uptake and Retention of DVD-Ig™ in Mouse Brain by Intravenous or Intraperitoneal Injection

Monday, February 10 | 2:00PM - 4:30PM
Workshop 1: Crossing the Blood-Brain Barrier
Room: Quandary Peak

Speaker 4 of 5
Morten Hanefeld Dziegiel, Copenhagen University Hospital, Denmark
Maternofetal Transplacental Transport of Novel Recombinant IgG Antibodies Lacking Effector Functions – Treatment of Maternal Pathogenic Antibodies

Monday, February 10 | 2:00PM - 4:30PM
Workshop 1: Crossing the Blood-Brain Barrier
Room: Quandary Peak

Speaker 5 of 5
Graham K. Farrington, Biogen Idec, USA
Intravenous Biological Activity of FC5Fc in Transporting Biologically Active Peptides across the BBB in a Hargreaves Model Correlates with Plasma Half-Life and Apparent Binding Affinity

Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
This session is from B Cells
Room: Longs Peak

Speaker 1 of 10
* Michael P. Cancro, University of Pennsylvania, USA


Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
This session is from B Cells
Room: Longs Peak

Speaker 2 of 10
* Frances E. Lund, University of Alabama at Birmingham, USA


Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
This session is from B Cells
Room: Longs Peak

Speaker 3 of 10
Jeffrey J. Bednarski, Washington University School of Medicine, USA
Signals from RAG DNA Breaks Attenuate Pre-BCR Activity through Sequential Activation of NF-kappaB2 and SpiC


Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
This session is from B Cells
Room: Longs Peak

Speaker 4 of 10
Hannes Bergmann, John Curtin School of Medical Research, Australian National University, Australia
Removal of p8-CD74 Peptides by Intramembrane Endopeptidase SPPL2A Is Crucial for B Cell Survival


Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
This session is from B Cells
Room: Longs Peak

Speaker 5 of 10
Barbara Bertocci, INSERM 783, France
KLHL6 Is an Adaptor of the Cullin-Based-E3-Ubiquitin Ligase Complex Responsible for Transitional B Cell Survival and Differentiation


Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
This session is from B Cells
Room: Longs Peak

Speaker 6 of 10
Keith M. Hamel, AbbVie, Inc., USA
The Epigenetic Reader Cecr2 in B-Lymphopoiesis


Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
This session is from B Cells
Room: Longs Peak

Speaker 7 of 10
Yogesh S. Jeelall, John Curtin School of Medical Research, Australian National University, Australia
Human Lymphoma Mutations Reveal CARD11 as the Switch between Self-Antigen-Induced B Cell Death or Proliferation and Autoantibody Production


Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
This session is from B Cells
Room: Longs Peak

Speaker 8 of 10
Beatriz León, University of Alabama at Birmingham, USA
Prolonged Antigen Presentation by Immune Complex-Binding Dendritic Cells Programs Memory CD8 T Cells


Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
This session is from B Cells
Room: Longs Peak

Speaker 9 of 10
Matthew S. Macauley, The Scripps Research Institute, USA
Siglec-Mediated B Cell Tolerance to Membrane Autoantigens


Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
This session is from B Cells
Room: Longs Peak

Speaker 10 of 10
Trang T.T. Nguyen, University of California, Davis, USA
Secreted IgM Enforces B Cell Central Tolerance Induction


Monday, February 10 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 10 | 5:00PM - 7:00PM
Treating Chronic Diseases of Metabolism with Antibody-Based
Therapeutics

Room: Quandary Peak

Speaker 1 of 4
* John A. Latham, Alder BioPharmaceuticals, USA

Monday, February 10 | 5:00PM - 7:00PM
Treating Chronic Diseases of Metabolism with Antibody-Based
Therapeutics

Room: Quandary Peak

Speaker 2 of 4
Neil Stahl, Regeneron Pharmaceuticals, USA
Alirocumab : Fully Human Antibody against PCSK9 Reduced LDL-C Both in Monotherapy and in Combination with Statins and Other Lipid Lowering Therapies in Preclinical and Early Clinical Studies

Monday, February 10 | 5:00PM - 7:00PM
Treating Chronic Diseases of Metabolism with Antibody-Based
Therapeutics

Room: Quandary Peak

Speaker 3 of 4
Peter Libby, Brigham and Women's Hospital, USA
Inflammation and Atherosclerosis: A Rationale for Antibody Treatment

Monday, February 10 | 5:00PM - 7:00PM
Treating Chronic Diseases of Metabolism with Antibody-Based
Therapeutics

Room: Quandary Peak

Speaker 4 of 4
Estelle Trifilieff, Novartis Institutes for Biomedical Research, Switzerland
Restore and Maintain Strong Body through Antibody Treatment in Skeletal Muscle Wasting Diseases

Monday, February 10 | 5:00PM - 7:15PM
Self-Tolerance and Autoimmunity
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 5
* Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Germinal Center Selection for Lower Autoantigen Affinity and for V-Regions Blocked by N-Glycans: Redemption of Autoantibodies Carried by Anergic B Cells in the Pre-Immune Repertoire


Monday, February 10 | 5:00PM - 7:15PM
Self-Tolerance and Autoimmunity
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 5
Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
(De-)Regulation of B Cell Activation


Monday, February 10 | 5:00PM - 7:15PM
Self-Tolerance and Autoimmunity
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 5
Roberta Pelanda, University of Colorado Denver, USA
Positive and Negative Selection of Primary B Cells


Monday, February 10 | 5:00PM - 7:15PM
Self-Tolerance and Autoimmunity
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 5
Robert C. Rickert, Pfizer Inc., USA
Short Talk: B Cell Tolerance to Gut-Associated Antigens


Monday, February 10 | 5:00PM - 7:15PM
Self-Tolerance and Autoimmunity
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 5 of 5
Claude-Agnès Reynaud, Necker-Paris Medical School, France
Short Talk: A Splenic Marginal Zone B-Cell Precursor with NOTCH2-Dependent Differentiation Properties in Humans


Monday, February 10 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys


Monday, February 10 | 7:30PM - 10:00PM
Poster Session 1
Room: Red Cloud/Shavano/Torreys


Tuesday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Tuesday, February 11 | 8:00AM - 11:00AM
Tailoring Therapeutics to Meet the Demands of Prophylactic a
nd Long-Term Therapy

Room: Quandary Peak

Speaker 1 of 5
* Marc Retter, Amgen Inc., USA

Tuesday, February 11 | 8:00AM - 11:00AM
Tailoring Therapeutics to Meet the Demands of Prophylactic a
nd Long-Term Therapy

Room: Quandary Peak

Speaker 2 of 5
Herren Wu, MedImmune, USA
Engineering Biosuperiors

Tuesday, February 11 | 8:00AM - 11:00AM
Tailoring Therapeutics to Meet the Demands of Prophylactic a
nd Long-Term Therapy

Room: Quandary Peak

Speaker 3 of 5
Javier Chaparro-Riggers, Rinat-Pfizer Inc., USA
Improving PK and Cholesterol Lowering by a pH-Sensitive Anti-PCSK9-Antibody

Tuesday, February 11 | 8:00AM - 11:00AM
Tailoring Therapeutics to Meet the Demands of Prophylactic a
nd Long-Term Therapy

Room: Quandary Peak

Speaker 4 of 5
Tomoyuki Igawa, Chugai Pharmabody Research, Singapore
Bispecific IgG Antibody against FIXa and FX (ACE910) for the Treatment of Hemophilia A


Tuesday, February 11 | 8:00AM - 11:00AM
Tailoring Therapeutics to Meet the Demands of Prophylactic a
nd Long-Term Therapy

Room: Quandary Peak

Speaker 5 of 5
CM Hsieh, Merck & Co., USA
Short Talk:Generation of ABT-122, an Anti-TNF/IL-17 DVD-Ig™ Molecule as a Potential Therapeutic Candidate for Rheumatoid Arthritis

Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 7
* Hedda Wardemann, German Cancer Research Center, Germany


Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 7
Susan K. Pierce, NIAID, National Institutes of Health, USA
How B Cells Remember


Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 7
Tomohiro Kurosaki, Osaka University, Japan
Calcium Signaling in B Lymphocytes


Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 7
Jeffrey V. Ravetch, Rockefeller University, USA
Regulating B Cell Activation


Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 5 of 7
Jürgen Wienands, Georg August University of Goettingen, Germany
Short Talk: Signal Perception by SLP65 Requires its Macromolecular Assembly at Vesicular Signaling Scaffolds


Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 6 of 7
Maria A. Curotto de Lafaille, New York University School of Medicine, USA
Short Talk: Regulation of IgE Cell Differentiation and Memory


Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 7 of 7
Kai-Michael Toellner, University of Birmingham, UK
Short Talk: Regulation of B Cell Responses by Antibody


Tuesday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 11 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Tuesday, February 11 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, February 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
This session is from B Cells
Room: Longs/Grays Peak

Speaker 1 of 9
* Anthony L. DeFranco, University of California, San Francisco, USA


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
This session is from B Cells
Room: Longs/Grays Peak

Speaker 2 of 9
* Jürgen Wienands, Georg August University of Goettingen, Germany


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
This session is from B Cells
Room: Longs/Grays Peak

Speaker 3 of 9
Wenxia Song, University of Maryland, USA
Actin-Mediated Attenuation of B-Cell Receptor Signaling Is Important for the Maintenance of B-Cell Tolerance


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
This session is from B Cells
Room: Longs/Grays Peak

Speaker 4 of 9
Alberto Martin, University of Toronto, Canada
Genome-Wide Screen Identifies kin17 as a Factor Required for Immunoglobulin Class Switch Recombination


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
This session is from B Cells
Room: Longs/Grays Peak

Speaker 5 of 9
Javier M. Di Noia, Institut de Recherches Cliniques de Montreal, Canada
An Atypical Dominant-Negative Effect of Truncated AID Variants on Isotype Switching Explains the Autosomal Dominant HIGM2 Syndrome


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
This session is from B Cells
Room: Longs/Grays Peak

Speaker 6 of 9
Carla R. Nowosad, Rockefeller University, USA
Determining the Architecture and Function of Immune Synapses within B Cell Populations


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
This session is from B Cells
Room: Longs/Grays Peak

Speaker 7 of 9
Mark R. Boothby, Vanderbilt University Medical Center, USA
Signaling Pathways in B Cell Survival and Humoral Memory


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
This session is from B Cells
Room: Longs/Grays Peak

Speaker 8 of 9
Isabelle Robert, Institute of Genetics and Molecular and Cellular Biology, France
Immunoglobulin Class Switch Recombination Is Negatively Regulated by Parp3


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
This session is from B Cells
Room: Longs/Grays Peak

Speaker 9 of 9
Pia Dosenovic, Karolinska Institutet, Sweden
Slc15a4 Function in Plasmacytoid Dendritic Cells Is Required for in vivo Class Switch Recombination to IgG2c in Response to CpGA


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Quandary Peak

Speaker 1 of 9
* Nicole Baumgarth, University of California, Davis, USA


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Quandary Peak

Speaker 2 of 9
Roberto DiNiro, University of Pittsburgh, USA
The B Cell Response to Salmonella typhimurium: Promiscuous B Cell Recruitment for Early Ab Followed by Extrafollicular Affinity Maturation


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Quandary Peak

Speaker 3 of 9
Rebecca A. Elsner, University of Pittsburgh, USA
The Lyme Disease Agent B. burgdorferi Inhibits Immunological Memory Formation by Suppressing Functional Germinal Center Responses


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Quandary Peak

Speaker 4 of 9
Eliver Eid Bou Ghosn, Emory University, USA
HSC-Independent Development of Antigen-Specific B-1a Memory


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Quandary Peak

Speaker 5 of 9
E. Ashley Moseman, NINDS, National Institutes of Health, USA
Adoptive B Cell Immunotherapy Accelerates Control of Chronic Viral Infection


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Quandary Peak

Speaker 6 of 9
Noel T. Pauli, Adimab LLC, USA
Staphylococcus aureus Infection Induces Affinity Maturation Derived Protein A-Mediated Immune Evasion in Humans


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Quandary Peak

Speaker 7 of 9
Kristin M.S. Schroeder, National Jewish Health, USA
Characterizing the HIV Envelope Antibody Response by Marginal Zone B Cells


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Quandary Peak

Speaker 8 of 9
Cristina Gil-Cruz, Kantonsspital St.Gallen, Switzerland
MyD88 Dependent Signals on FRC-Like Cells on Peyer's Patches Control Immune Responses against Pathogens


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Quandary Peak

Speaker 9 of 9
Adnan R. Khan, UCB Celltech, UK
'The Breg Gets the Worm:' How Helminths Can Shed a Light on Regulatory B Cells


Tuesday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 11 | 5:00PM - 7:00PM
Overcoming Challenging Indications for Antibody Therapeutics
Room: Quandary Peak

Speaker 1 of 5
* Margaret Karow, Akrevia Therapeutics, USA

Tuesday, February 11 | 5:00PM - 7:00PM
Overcoming Challenging Indications for Antibody Therapeutics
Room: Quandary Peak

Speaker 2 of 5
Bruce L. Roberts, Vedanta Biosciences, USA
New Insights into the Mechanism of Action of Alemtuzumab

Tuesday, February 11 | 5:00PM - 7:00PM
Overcoming Challenging Indications for Antibody Therapeutics
Room: Quandary Peak

Speaker 3 of 5
Ronald A. Ignotz, University of Massachusetts Medical School, USA
Short Talk: Topical Anti-TNF-alpha Antibody Enhances Wound Healing in Diabetic Mice

Tuesday, February 11 | 5:00PM - 7:00PM
Overcoming Challenging Indications for Antibody Therapeutics
Room: Quandary Peak

Speaker 4 of 5
Andreas Grauer, Amgen, USA
Targeting Osteoporosis: Increasing Bone Strength with Antibodies against RANK-L
and Sclerostin


Tuesday, February 11 | 5:00PM - 7:00PM
Overcoming Challenging Indications for Antibody Therapeutics
Room: Quandary Peak

Speaker 5 of 5
Ronald B. DeMattos, Lilly Research Laboratories, USA
Engaging the Enemy: Improving the Efficacy of Anti- beta-Amyloid Antibodies

Tuesday, February 11 | 5:00PM - 7:15PM
B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 5
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
B Cell Memory to Infection


Tuesday, February 11 | 5:00PM - 7:15PM
B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 5
* Patrick C. Wilson, University of Chicago, USA
B Cell Immunity to Influenza in Humans


Tuesday, February 11 | 5:00PM - 7:15PM
B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 5
Hedda Wardemann, German Cancer Research Center, Germany
B Cell Clonal Selection


Tuesday, February 11 | 5:00PM - 7:15PM
B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 5
Scott D. Boyd, Stanford University, USA
Short Talk: Convergent Antibodies Are a Hallmark of Influenza Vaccine Seroconversion


Tuesday, February 11 | 5:00PM - 7:15PM
B Cell Responses to Foreign Antigens
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 5 of 5
Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Short Talk: The Multifaceted Role of Il-21r/Stat3 Signaling in Regulating Humoral Immunity and Memory in Humans


Tuesday, February 11 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys


Tuesday, February 11 | 7:30PM - 10:00PM
Poster Session 2
Room: Red Cloud/Shavano/Torreys


Wednesday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Wednesday, February 12 | 8:00AM - 11:00AM
Prophylaxis versus Therapeutic Treatment of Infectious Disea
se

Room: Quandary Peak

Speaker 1 of 5
* Michael A. Barry, Mayo Clinic, USA

Wednesday, February 12 | 8:00AM - 11:00AM
Prophylaxis versus Therapeutic Treatment of Infectious Disea
se

Room: Quandary Peak

Speaker 2 of 5
Arturo Casadevall, Albert Einstein College of Medicine, USA
A New Synthesis for Antibody-Mediated Immunity

Wednesday, February 12 | 8:00AM - 11:00AM
Prophylaxis versus Therapeutic Treatment of Infectious Disea
se

Room: Quandary Peak

Speaker 3 of 5
Deborah C. Molrine, University of Massachusetts Medical School, USA
Antibody Mixtures: Treating Clostridium difficile with an Antibody Combination

Wednesday, February 12 | 8:00AM - 11:00AM
Prophylaxis versus Therapeutic Treatment of Infectious Disea
se

Room: Quandary Peak

Speaker 4 of 5
Charles Ken Stover, MedImmune, LLC, USA
A Novel Multi-Mechanistic Monoclonal Antibody for Treating P. aeruginosa Infections

Wednesday, February 12 | 8:00AM - 11:00AM
Prophylaxis versus Therapeutic Treatment of Infectious Disea
se

Room: Quandary Peak

Speaker 5 of 5
Gene Tan, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Characterization of a Broadly Neutralizing Monoclonal Antibody that Targets the Fusion Domain of the Group 2 Hemagglutinin of Influenza A Virus

Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 7
Marc K. Jenkins, University of Minnesota Medical School, USA
Origins of CD4+ Effector and Memory T Cells during Bacterial Infection


Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 7
Michael G. McHeyzer-Williams, The Scripps Research Institute, USA
Intra-Clonal Analysis of B Cell Memory


Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 7
Carola G. Vinuesa, Australian National University, Australia
Novel Mechanisms Controlling Mouse and Human Follicular T Cell Homeostasis


Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 7
Shane Crotty, La Jolla Institute for Immunology, USA
T Cell Help to B Cells: Differentiation and Function of Follicular Helper CD4 T Cells (Tfh)


Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 5 of 7
* Hai Qi, Tsinghua University, China
Short Talk: Short-Lived T-B Entanglement in the Germinal Center and the Generation of High-Affinity BM Plasma Cells


Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 6 of 7
Hui Hu, University of Alabama at Birmingham, USA
Short Talk: Foxp1 Is a Rate-Limiting and Essential Negative Regulator of TFH Cell Differentiation


Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 7 of 7
Andre Ballesteros-Tato, University of Alabama at Birmingham, USA
Short Talk: FoxP3+ Regulatory T Cells Promote Influenza-Specific Tfh Cell Responses in vivo by Regulating IL-2


Wednesday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 12 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Wednesday, February 12 | 11:00AM - 2:00PM
On Own for Lunch and Recreation


Wednesday, February 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Wednesday, February 12 | 2:00PM - 4:30PM
Workshop 2: When an Antibody Isn't Enough
Room: Quandary Peak

Speaker 1 of 6
* Hilde Revets, Ablynx, Belgium

Wednesday, February 12 | 2:00PM - 4:30PM
Workshop 2: When an Antibody Isn't Enough
Room: Quandary Peak

Speaker 2 of 6
Barbara S. Fox, Tilos Therapeutics, Inc., USA
AVX-470: A Novel Orally-Delivered Polyclonal Anti-TNF Antibody Designed to Work Locally in the GI Tract

Wednesday, February 12 | 2:00PM - 4:30PM
Workshop 2: When an Antibody Isn't Enough
Room: Quandary Peak

Speaker 3 of 6
Anthony B. Cooper, Adimab, LLC, USA
Non-Viral Adeno Associated Virus-Based Platform for Stable Expression of Antibody Combination Therapeutics

Wednesday, February 12 | 2:00PM - 4:30PM
Workshop 2: When an Antibody Isn't Enough
Room: Quandary Peak

Speaker 4 of 6
Rastislav Tamaskovic, University of Zürich, Switzerland
Intermolecular Trapping of ErbB2 Receptor Disables ErbB Signaling Network and Induces Apoptosis in ErbB2-Addicted Tumors

Wednesday, February 12 | 2:00PM - 4:30PM
Workshop 2: When an Antibody Isn't Enough
Room: Quandary Peak

Speaker 5 of 6
Kipp Weiskopf, Stanford University, USA
High-Affinity SIRPalpha Variants Enhance Macrophage Destruction of Small Cell Lung Cancer

Wednesday, February 12 | 2:00PM - 4:30PM
Workshop 2: When an Antibody Isn't Enough
Room: Quandary Peak

Speaker 6 of 6
Nicholas J. Veomett, Weill Cornell Medical College, USA
Targeting the Intracellular WT1 Oncoprotein with Multiple Therapeutic Antibody Modalities

Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
This session is from B Cells
Room: Castle Peaks

Speaker 1 of 11
* Ann M. Haberman, Yale University School of Medicine, USA


Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
This session is from B Cells
Room: Castle Peaks

Speaker 2 of 11
* Takaharu Okada, RIKEN, Japan


Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
This session is from B Cells
Room: Castle Peaks

Speaker 3 of 11
Simon N. Willis, Walter and Eliza Hall Institute, Australia
Transcription Factor IRF4 Regulates Germinal Center Cell Formation through a B Cell-Intrinsic Mechanism


Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
This session is from B Cells
Room: Castle Peaks

Speaker 4 of 11
Peter Sage, Harvard Medical School, USA
Specialization of Memory-Like Circulating T Follicular Helper and T Follicular Regulatory Cells


Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
This session is from B Cells
Room: Castle Peaks

Speaker 5 of 11
Michela Locci, University of Pennsylvania, USA
Human Blood CXCR5+ PD-1+CXCR3- CD4 T Cells Are Highly Functional Circulating Memory Tfh Cells


Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
This session is from B Cells
Room: Castle Peaks

Speaker 6 of 11
Tharu M. Fernando, Genentech, Inc., USA
Heat Shock Factor 1 Induces BCL6 to Mediate Stress Tolerance


Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
This session is from B Cells
Room: Castle Peaks

Speaker 7 of 11
Seung Goo Kang, Kangwon National University, South Korea
Essential Roles of miR-17~92 Family miRNAs in Regulating Lymphoid Effector Programs


Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
This session is from B Cells
Room: Castle Peaks

Speaker 8 of 11
Florian Weisel, University of Pittsburgh, USA
A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells


Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
This session is from B Cells
Room: Castle Peaks

Speaker 9 of 11
Alexander D. Gitlin, Rockefeller University, USA
Cellular Dynamics Underlying Selection of B Cells in the Germinal Center


Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
This session is from B Cells
Room: Castle Peaks

Speaker 10 of 11
Roy Ramiscal, John Curtin School of Medical Research, Australian National University, Australia
Germinal Center T Follicular Helper Cells Are a Metabolically Distinct Subset of Effector T Cells


Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
This session is from B Cells
Room: Castle Peaks

Speaker 11 of 11
Ziv Shulman, Weizmann Institute, Israel
Prolonged T Follicular Helper Cell Calcium Mobilization during B Cell Selection in Germinal Centers


Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 10
* Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Germany


Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 10
* Stuart G. Tangye, Garvan Institute of Medical Research, Australia


Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 10
Jean-Nicolas Schickel, Adimab, LLC, USA
Expanded VH4-34+IgG+ Memory B Cells in IRAK-4 and MyD88-Deficient and SLE Patients Recognize Commensal Bacteria


Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 10
Alexander Frühwirth, Institute for Research in Biomedicine, Switzerland
Identification of a Marker for Recently Activated Memory B Cells


Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 5 of 10
Pierre J. Milpied, The Scripps Research Institute, USA
Intraclonal Analysis of Memory B Cell Functional Plasticity


Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 6 of 10
Justin J. Taylor, Fred Hutchinson Cancer Research Center, USA
Analysis of the Differentiation of a Single Antigen-Specific Naïve B Cell Early in the Primary Response


Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 7 of 10
Niklas Engels, Georg August University Goettingen, Germany
The Immunoglobulin Tail Tyrosine in Surface IgG Promotes T Cell Independent Reactivation of IgG-Switched Memory B Cells


Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 8 of 10
Tyani D. Chan, Garvan Institute of Medical Research, Australia
Novel Regulatory Control of IgE Antibody Responses


Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 9 of 10
Kathryn A. Pape, University of Minnesota, USA
Generation of IgA Plasma Cells during a Secondary Response in the Absence of IgA Memory B Cells


Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 10 of 10
Kaval Kaur, Agency for Science, Technology and Research, Singapore
SLE Patients Make Higher Affinity Antibody Responses to Influenza Vaccination


Wednesday, February 12 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 12 | 5:00PM - 7:15PM
In vivo Induction of Therapeutic Antibodies for Prophylactic
Treatment of Disease

Room: Quandary Peak

Speaker 1 of 5
* Peter M. Palese, Icahn School of Medicine at Mount Sinai, USA
Redirecting the Immune Response of the Influenza Virus Hemagglutinin to the Conserved Stalk of the Hemagglutinin and Neuraminidase

Wednesday, February 12 | 5:00PM - 7:15PM
In vivo Induction of Therapeutic Antibodies for Prophylactic
Treatment of Disease

Room: Quandary Peak

Speaker 2 of 5
Ronald G. Crystal, Weill Medical College of Cornell University, USA
Viral Vectors as Platforms for Anti-Addiction Vaccines

Wednesday, February 12 | 5:00PM - 7:15PM
In vivo Induction of Therapeutic Antibodies for Prophylactic
Treatment of Disease

Room: Quandary Peak

Speaker 3 of 5
Lélia Delamarre, Genentech, Inc., USA
Antibody-Mediated Antigen Delivery for Vaccine Antigens to Dendritic Cells

Wednesday, February 12 | 5:00PM - 7:15PM
In vivo Induction of Therapeutic Antibodies for Prophylactic
Treatment of Disease

Room: Quandary Peak

Speaker 4 of 5
Seleeke F. Flingai, University of Pennsylvania, USA
Short Talk: Generation of DNA Plasmid-Encoded Broadly Neutralizing Antibodies in vivo

Wednesday, February 12 | 5:00PM - 7:15PM
In vivo Induction of Therapeutic Antibodies for Prophylactic
Treatment of Disease

Room: Quandary Peak

Speaker 5 of 5
Erin Crossey, University of New Mexico, USA
Short Talk: Generation of a Cholesterol-Lowering Vaccine that Targets PCSK9

Wednesday, February 12 | 5:00PM - 7:15PM
Germinal Center Biology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 5
David M. Tarlinton, Monash University, Australia
The Impact of Arginine Methylation on B-Cell Responsiveness


Wednesday, February 12 | 5:00PM - 7:15PM
Germinal Center Biology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 5
Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
The Ins and Outs of Germinal Centers: Selection, Generation and Identity


Wednesday, February 12 | 5:00PM - 7:15PM
Germinal Center Biology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 5
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Germinal Center Biology


Wednesday, February 12 | 5:00PM - 7:15PM
Germinal Center Biology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 5
* Gabriel D. Victora, Rockefeller University, USA
Short Talk: T Follicular Helper Cell Dynamics in Germinal Centers


Wednesday, February 12 | 5:00PM - 7:15PM
Germinal Center Biology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 5 of 5
Roger Sciammas, University of California, Davis, USA
Short Talk: Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4


Wednesday, February 12 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys


Wednesday, February 12 | 7:30PM - 10:00PM
Poster Session 3
Room: Red Cloud/Shavano/Torreys


Thursday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 1 of 7
Max D. Cooper, Emory University, USA
Immune System Ontogeny and Phylogeny

Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 2 of 7
David G. Schatz, Yale University School of Medicine, USA
Targeting of V(D)J Recombination and Somatic Hypermutation

Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 3 of 7
Cristina Rada, MRC Laboratory of Molecular Biology, UK
Ig Gene Mutagenesis

Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 4 of 7
Frederick W. Alt, Boston Children's Hospital, USA
Role of Target Sequences in Frequency and Outcome of AID-Initiated Mutational and Deletional Events

Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 5 of 7
* F. Nina Papavasiliou, Deutsches Krebsforschungszentrum, Germany
Short Talk: Generation of Diversity: Beyond Genomic Changes

Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 6 of 7
Changchun Xiao, The Scripps Research Institute, USA
Short Talk: MicroRNA-17~92 Plays a Causative Role in Lymphomagenesis by Coordinating Multiple Oncogenic Pathways

Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 7 of 7
Carol E. Schrader, University of Massachusetts, USA
Short Talk: The Effect of AP Endonuclease on Somatic Hypermutation of IgH Variable Region Genes

Thursday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 13 | 11:30AM - 2:00PM
On Own for Lunch and Recreation


Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
Room: Quandary Peak

Speaker 1 of 7
* Peter Brams, Zai Lab, USA

Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
Room: Quandary Peak

Speaker 2 of 7
Fabricio Montalvao, Institut Pasteur, France
The Mechanism of Anti-CD20-Mediated B-Cell Depletion Revealed by Intravital Imaging

Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
Room: Quandary Peak

Speaker 3 of 7
Karin A. van Schie, Sanquin Research, University of Amsterdam, Netherlands
Anti-Drug Antibodies to All Anti-TNFalpha Therapeutic Antibodies Are Largely Neutralizing

Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
Room: Quandary Peak

Speaker 4 of 7
Nancy E. Everds, Amgen, Inc, USA
Off-Target Effects of Therapeutic mAbs on Peripheral Blood Cells

Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
Room: Quandary Peak

Speaker 5 of 7
Stefan Barghorn, AbbVie, Inc., Germany
Off Target Toxicity of an Anti-Amyloid Beta Antibody for Alzheimer's Disease Immunotherapy

Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
Room: Quandary Peak

Speaker 6 of 7
Mark J. Kwakkenbos, AIMM Therapeutics, Netherlands
In vitro B Cell Affinity Maturation Selects for Antibodies with Increased Neutralizing Activity and Stability

Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
Room: Quandary Peak

Speaker 7 of 7
Nathan J. Alves, Indiana University, USA
Advancing Antibody Targeted Therapies through Site-Specific UV Conjugation of Functional Ligands to the Conserved Antibody Nucleotide Binding Site (NBS)

Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 9
* Eric Meffre, Yale University School of Medicine, USA


Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 9
Nobuo Sakaguchi, Kumamoto University, Japan
GANP Plays a Regulatory Role in the Choice of DNA Repair Pathway by Dissociating DNA-PKcs in AID-Induced Immunoglobulin V-Region Diversification


Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 9
Wai Yen Alfred Lim, MRC Laboratory of Molecular Biology, UK
Directed Evolution of scFvs Using the Hypermutating DT40 B-Cell Line


Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 9
Xiaohua Wang, Asclepius Therapy, USA
A Source of the Single-Stranded DNA Substrate for Activation-Induced Deaminase during Somatic Hypermutation


Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 5 of 9
Amanda C. Drennan, University of Wisconsin, Madison, USA
Canonical and Non-Canonical JAK1 Signaling in Diffuse Large B-Cell Lymphoma


Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 6 of 9
Virginia G. de Yébenes, Centro Nacional de Investigaciones Cardiovasculares, Spain
miR-217 Is an Oncogene that Enhances the Germinal Center Reaction


Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 7 of 9
Daniel Gadala-Maria, Yale University, USA
Genotyping Methods for Improving Detection of Immunoglobulin Mutations


Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 8 of 9
Adrienne Greenough, Duke University, USA
Identifying the Landscape of Genetic Alterations in the Lymphoma Transcriptome


Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 9 of 9
Sébastien Storck, Institut Necker-Enfants Malades, France
AID Expression Restricted to the G1 Phase of the Cell Cycle Recapitulates the Mutation Spectrum of Immunoglobulin Genes


Thursday, February 13 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 13 | 5:00PM - 7:00PM
What We've Learned from Antibody Treatment of Inflammation
Room: Quandary Peak

Speaker 1 of 4
* Neil Graham, Regeneron Pharmaceuticals, USA

Thursday, February 13 | 5:00PM - 7:00PM
What We've Learned from Antibody Treatment of Inflammation
Room: Quandary Peak

Speaker 2 of 4
Meena Subramanyam, Biogen Idec, USA
Immunogenicity of Monoclonal Antibody Therapeutics: Experiences and Lessons Learned


Thursday, February 13 | 5:00PM - 7:00PM
What We've Learned from Antibody Treatment of Inflammation
Room: Quandary Peak

Speaker 3 of 4
Neil Graham, Regeneron Pharmaceuticals, USA
Lessons Learned in the Therapeutic Blockade of Th2 Inflammation in Asthma and Atopic Dermatitis Culminating in Dupilumab, a blocker of IL4 Receptor

Thursday, February 13 | 5:00PM - 7:00PM
What We've Learned from Antibody Treatment of Inflammation
Room: Quandary Peak

Speaker 4 of 4
Thomas A. Waldmann, National Institutes of Health, USA
What We Are Still Learning about Anti-CD25 Therapy after 25 Years with Daclizumab

Thursday, February 13 | 5:00PM - 7:15PM
B Cell Cancer Biology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 1 of 5
Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
Modeling B Cell Lymphomagenesis in Mice


Thursday, February 13 | 5:00PM - 7:15PM
B Cell Cancer Biology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 2 of 5
Louis M. Staudt, NCI, National Institutes of Health, USA
Therapies Targeting Pathological Signaling in B Cell Lymphomas


Thursday, February 13 | 5:00PM - 7:15PM
B Cell Cancer Biology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 3 of 5
Riccardo Dalla-Favera, Columbia University, USA
Molecular Genetics of Diffuse Large B Cell Lymphoma


Thursday, February 13 | 5:00PM - 7:15PM
B Cell Cancer Biology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 4 of 5
* Ralf Küppers, University of Duisburg-Essen, Medical School, Germany
Short Talk: Aspects of the Pathogenesis of Hodgkin Lymphoma


Thursday, February 13 | 5:00PM - 7:15PM
B Cell Cancer Biology
This session is from B Cells
Room: Longs/Grays Peaks

Speaker 5 of 5
Uttiya Basu, USA
Short Talk: Noncoding RNA Processing Promotes AID Targeting to the B Cell Genome


Thursday, February 13 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys


Thursday, February 13 | 8:00PM - 11:00PM
Entertainment
Room: Red Cloud/Shavano/Torreys


Thursday, February 13 | 8:00PM - 11:00PM
Cash Bar
Room: Red Cloud/Shavano/Torreys


Friday, February 14 | 10:25AM - 10:25AM
Departure


*Session Chair.