Web Desc
Biology of B Cell Responses
joint with Prophylactic and Therapeutic Antibodies
Organizer(s): Hedda Wardemann, Michael G. McHeyzer-Williams and Michel C. Nussenzweig
Date: February 09 - 14, 2014
Location: Keystone Resort, Keystone, CO, USA
Sponsored by BioLegend, Inc. and Celgene Corporation.
Summary of Meeting:
The requirements and processes relevant for the induction of protective B cell responses remain largely unclear, and inefficient or deregulated B cell responses are frequently associated with the development of diseases. The goal of this meeting is to deepen our understanding of the factors and mechanisms controlling and regulating B cell development, differentiation and activation under steady-state conditions and in autoimmunity, infection and B cell tumors. The specific aims are to: 1) Identify factors involved in the developmental programming and function of B cells; 2) Elucidate the mechanisms relevant for the establishment and maintenance of B cell self-tolerance; 3) Define how B cell responses are initiated and regulated; 4) Provide insight into the mechanisms and dynamics underlying germinal center responses; and 5) Establish the link between immunoglobulin gene diversification and B cell tumor development. The meeting will provide a platform for early-stage and established researchers to engage in interactive discussions on all aspects of the biology of B cell responses from B cell evolution to basic principles of B cell biology and human B cell immunology. It will thereby facilitate and booster the exchange of ideas and the initiation of collaborative research on B cells at an international level. Interactions will be fostered across disciplines. Access to the parallel meeting on “Prophylactic and Therapeutic Antibodies” will provide all attendees with the unique opportunity to engage in expanded interdisciplinary interaction with translational scientists from academia and industry.
Scholarship Deadline: October 16 2013
Discounted Abstract Deadline: October 16 2013
Abstract Deadline: November 14 2013
Discounted Registration Deadline: December 10 2013
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
BioLegend, Inc.Celgene Corporation
We gratefully acknowledge additional support for this conference from:
MedImmune
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI109612-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 09 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Monday, February 10 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Monday, February 10 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Longs/Grays Peaks

Speaker 1 of 1
Jason G. Cyster, HHMI/University of California, San Francisco, USA
Deciphering the Guidance Cue Code for B Cell Immunity

Monday, February 10 | 9:00AM - 11:35AM
Programming B Cell Physiology
Room: Longs/Grays Peaks

Speaker 1 of 5
Barry P. Sleckman, University of Alabama Birmingham School of Medicine, USA
Regulation of B Cell Development by Signals from RAG-Mediated DNA Double Strand Breaks

Monday, February 10 | 9:00AM - 11:35AM
Programming B Cell Physiology
Room: Longs/Grays Peaks

Speaker 2 of 5
Cornelis Murre, University of California, San Diego, USA
Global Analysis of Long-Range Genomic Interactions that Orchestrate Lymphocyte Cell Fate

Monday, February 10 | 9:00AM - 11:35AM
Programming B Cell Physiology
Room: Longs/Grays Peaks

Speaker 3 of 5
Hassan Jumaa, Institute for Immunology, Ulm University Hospital, Germany
Pre B Cell Development

Monday, February 10 | 9:00AM - 11:35AM
Programming B Cell Physiology
Room: Longs/Grays Peaks

Speaker 4 of 5
* Stephen L. Nutt, Walter and Eliza Hall Institute, Australia
Short Talk: The Intrinsic and Extrinsic Controls of Late B Cell Differentiation

Monday, February 10 | 9:00AM - 11:35AM
Programming B Cell Physiology
Room: Longs/Grays Peaks

Speaker 5 of 5
Amy L. Kenter, University of Illinois College of Medicine, USA
Short Talk: Class Switch Recombination can Precede V(D)J Joining during Early B Cell Development: Consequences and Implications in vivo

Monday, February 10 | 9:15AM - 11:30AM
Novel Antibody Therapy for Pain
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 1 of 4
* Margaret Karow, Akrevia Therapeutics, USA


Monday, February 10 | 9:15AM - 11:30AM
Novel Antibody Therapy for Pain
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 2 of 4
Mark T. Brown, Pfizer, USA
Overview of Analgesic Efficacy and Safety of Tanezumab, a Monoclonal Antibody Targeting Nerve Growth Factor for Treatment of Chronic Pain


Monday, February 10 | 9:15AM - 11:30AM
Novel Antibody Therapy for Pain
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 3 of 4
John A. Latham, Alder BioPharmaceuticals, USA
The Discovery and Development of an Anti-CGRP Antibody ALD403 for the Treatment of Migraine


Monday, February 10 | 9:15AM - 11:30AM
Novel Antibody Therapy for Pain
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 4 of 4
Stephen P. Squinto, OrbiMed Healthcare Fund Management, USA
Development of a Terminal Complement Inhibitor for the Treatment of Life-Threatening Ultra Rare Chronic Diseases


Monday, February 10 | 9:40AM - 10:00AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 10 | 11:30AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Monday, February 10 | 11:35AM - 2:30PM
On Own for Lunch and Recreation


Monday, February 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Monday, February 10 | 2:00PM - 4:30PM
Workshop 1: Crossing the Blood-Brain Barrier
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 1 of 5
Jean E. Lachowicz, Angiochem, Canada
Creation of a Brain-Penetrant Peptide-Antibody Conjugate that Targets Brain Tumors and Increases Survival in Mice with Intracranial HER2+ Tumors


Monday, February 10 | 2:00PM - 4:30PM
Workshop 1: Crossing the Blood-Brain Barrier
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 2 of 5
* Robert G. Thorne, Denali Therapeutics, USA
Bypassing the Blood-Brain Barrier to Directly Deliver Antibodies and Antibody Fragments
to Central Nervous System Target Sites


Monday, February 10 | 2:00PM - 4:30PM
Workshop 1: Crossing the Blood-Brain Barrier
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 3 of 5
Denise D. Karaoglu, AbbVie Bioresearch Center, USA
Uptake and Retention of DVD-Ig™ in Mouse Brain by Intravenous or Intraperitoneal Injection


Monday, February 10 | 2:00PM - 4:30PM
Workshop 1: Crossing the Blood-Brain Barrier
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 4 of 5
Morten Hanefeld Dziegiel, Copenhagen University Hospital, Denmark
Maternofetal Transplacental Transport of Novel Recombinant IgG Antibodies Lacking Effector Functions – Treatment of Maternal Pathogenic Antibodies


Monday, February 10 | 2:00PM - 4:30PM
Workshop 1: Crossing the Blood-Brain Barrier
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 5 of 5
Graham K. Farrington, Biogen Idec, USA
Intravenous Biological Activity of FC5Fc in Transporting Biologically Active Peptides across the BBB in a Hargreaves Model Correlates with Plasma Half-Life and Apparent Binding Affinity


Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
Room: Longs Peak

Speaker 1 of 10
* Michael P. Cancro, University of Pennsylvania, USA

Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
Room: Longs Peak

Speaker 2 of 10
* Frances E. Lund, University of Alabama at Birmingham, USA

Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
Room: Longs Peak

Speaker 3 of 10
Jeffrey J. Bednarski, Washington University School of Medicine, USA
Signals from RAG DNA Breaks Attenuate Pre-BCR Activity through Sequential Activation of NF-kappaB2 and SpiC

Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
Room: Longs Peak

Speaker 4 of 10
Hannes Bergmann, John Curtin School of Medical Research, Australian National University, Australia
Removal of p8-CD74 Peptides by Intramembrane Endopeptidase SPPL2A Is Crucial for B Cell Survival

Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
Room: Longs Peak

Speaker 5 of 10
Barbara Bertocci, INSERM 783, France
KLHL6 Is an Adaptor of the Cullin-Based-E3-Ubiquitin Ligase Complex Responsible for Transitional B Cell Survival and Differentiation

Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
Room: Longs Peak

Speaker 6 of 10
Keith M. Hamel, AbbVie, Inc., USA
The Epigenetic Reader Cecr2 in B-Lymphopoiesis

Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
Room: Longs Peak

Speaker 7 of 10
Yogesh S. Jeelall, John Curtin School of Medical Research, Australian National University, Australia
Human Lymphoma Mutations Reveal CARD11 as the Switch between Self-Antigen-Induced B Cell Death or Proliferation and Autoantibody Production

Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
Room: Longs Peak

Speaker 8 of 10
Beatriz León, University of Alabama at Birmingham, USA
Prolonged Antigen Presentation by Immune Complex-Binding Dendritic Cells Programs Memory CD8 T Cells

Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
Room: Longs Peak

Speaker 9 of 10
Matthew S. Macauley, The Scripps Research Institute, USA
Siglec-Mediated B Cell Tolerance to Membrane Autoantigens

Monday, February 10 | 2:30PM - 4:30PM
Workshop 1: From B Cell Selection and Homeostasis to Program
ming and Functions
Room: Longs Peak

Speaker 10 of 10
Trang T.T. Nguyen, University of California, Davis, USA
Secreted IgM Enforces B Cell Central Tolerance Induction

Monday, February 10 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 10 | 5:00PM - 7:15PM
Self-Tolerance and Autoimmunity
Room: Longs/Grays Peaks

Speaker 1 of 5
* Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Germinal Center Selection for Lower Autoantigen Affinity and for V-Regions Blocked by N-Glycans: Redemption of Autoantibodies Carried by Anergic B Cells in the Pre-Immune Repertoire

Monday, February 10 | 5:00PM - 7:15PM
Self-Tolerance and Autoimmunity
Room: Longs/Grays Peaks

Speaker 2 of 5
Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
(De-)Regulation of B Cell Activation

Monday, February 10 | 5:00PM - 7:15PM
Self-Tolerance and Autoimmunity
Room: Longs/Grays Peaks

Speaker 3 of 5
Roberta Pelanda, University of Colorado Denver, USA
Positive and Negative Selection of Primary B Cells

Monday, February 10 | 5:00PM - 7:15PM
Self-Tolerance and Autoimmunity
Room: Longs/Grays Peaks

Speaker 4 of 5
Robert C. Rickert, Pfizer Inc., USA
Short Talk: B Cell Tolerance to Gut-Associated Antigens

Monday, February 10 | 5:00PM - 7:15PM
Self-Tolerance and Autoimmunity
Room: Longs/Grays Peaks

Speaker 5 of 5
Claude-Agnès Reynaud, Necker-Paris Medical School, France
Short Talk: A Splenic Marginal Zone B-Cell Precursor with NOTCH2-Dependent Differentiation Properties in Humans

Monday, February 10 | 5:00PM - 7:00PM
Treating Chronic Diseases of Metabolism with Antibody-Based
Therapeutics
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 1 of 4
* John A. Latham, Alder BioPharmaceuticals, USA


Monday, February 10 | 5:00PM - 7:00PM
Treating Chronic Diseases of Metabolism with Antibody-Based
Therapeutics
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 2 of 4
Neil Stahl, Regeneron Pharmaceuticals, USA
Alirocumab : Fully Human Antibody against PCSK9 Reduced LDL-C Both in Monotherapy and in Combination with Statins and Other Lipid Lowering Therapies in Preclinical and Early Clinical Studies


Monday, February 10 | 5:00PM - 7:00PM
Treating Chronic Diseases of Metabolism with Antibody-Based
Therapeutics
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 3 of 4
Peter Libby, Brigham and Women's Hospital, USA
Inflammation and Atherosclerosis: A Rationale for Antibody Treatment


Monday, February 10 | 5:00PM - 7:00PM
Treating Chronic Diseases of Metabolism with Antibody-Based
Therapeutics
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 4 of 4
Estelle Trifilieff, Novartis Institutes for Biomedical Research, Switzerland
Restore and Maintain Strong Body through Antibody Treatment in Skeletal Muscle Wasting Diseases


Monday, February 10 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys


Monday, February 10 | 7:30PM - 10:00PM
Poster Session 1
Room: Red Cloud/Shavano/Torreys


Tuesday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
Room: Longs/Grays Peaks

Speaker 1 of 7
* Hedda Wardemann, German Cancer Research Center, Germany

Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
Room: Longs/Grays Peaks

Speaker 2 of 7
Susan K. Pierce, NIAID, National Institutes of Health, USA
How B Cells Remember

Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
Room: Longs/Grays Peaks

Speaker 3 of 7
Tomohiro Kurosaki, Osaka University, Japan
Calcium Signaling in B Lymphocytes

Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
Room: Longs/Grays Peaks

Speaker 4 of 7
Jeffrey V. Ravetch, Rockefeller University, USA
Regulating B Cell Activation

Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
Room: Longs/Grays Peaks

Speaker 5 of 7
Jürgen Wienands, Georg August University of Goettingen, Germany
Short Talk: Signal Perception by SLP65 Requires its Macromolecular Assembly at Vesicular Signaling Scaffolds

Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
Room: Longs/Grays Peaks

Speaker 6 of 7
Maria A. Curotto de Lafaille, New York University School of Medicine, USA
Short Talk: Regulation of IgE Cell Differentiation and Memory

Tuesday, February 11 | 8:00AM - 11:00AM
Initiating and Regulating B Cell Responses
Room: Longs/Grays Peaks

Speaker 7 of 7
Kai-Michael Toellner, University of Birmingham, UK
Short Talk: Regulation of B Cell Responses by Antibody

Tuesday, February 11 | 8:00AM - 11:00AM
Tailoring Therapeutics to Meet the Demands of Prophylactic a
nd Long-Term Therapy
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 1 of 5
* Marc Retter, Amgen Inc., USA


Tuesday, February 11 | 8:00AM - 11:00AM
Tailoring Therapeutics to Meet the Demands of Prophylactic a
nd Long-Term Therapy
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 2 of 5
Herren Wu, MedImmune, USA
Engineering Biosuperiors


Tuesday, February 11 | 8:00AM - 11:00AM
Tailoring Therapeutics to Meet the Demands of Prophylactic a
nd Long-Term Therapy
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 3 of 5
Javier Chaparro-Riggers, Rinat-Pfizer Inc., USA
Improving PK and Cholesterol Lowering by a pH-Sensitive Anti-PCSK9-Antibody


Tuesday, February 11 | 8:00AM - 11:00AM
Tailoring Therapeutics to Meet the Demands of Prophylactic a
nd Long-Term Therapy
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 4 of 5
Tomoyuki Igawa, Chugai Pharmabody Research, Singapore
Bispecific IgG Antibody against FIXa and FX (ACE910) for the Treatment of Hemophilia A


Tuesday, February 11 | 8:00AM - 11:00AM
Tailoring Therapeutics to Meet the Demands of Prophylactic a
nd Long-Term Therapy
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 5 of 5
CM Hsieh, Merck & Co., USA
Short Talk:Generation of ABT-122, an Anti-TNF/IL-17 DVD-Ig™ Molecule as a Potential Therapeutic Candidate for Rheumatoid Arthritis


Tuesday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 11 | 11:00AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Tuesday, February 11 | 11:00AM - 2:30PM
On Own for Lunch and Recreation


Tuesday, February 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
Room: Longs/Grays Peak

Speaker 1 of 9
* Anthony L. DeFranco, University of California, San Francisco, USA

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
Room: Longs/Grays Peak

Speaker 2 of 9
* Jürgen Wienands, Georg August University of Goettingen, Germany

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
Room: Longs/Grays Peak

Speaker 3 of 9
Wenxia Song, University of Maryland, USA
Actin-Mediated Attenuation of B-Cell Receptor Signaling Is Important for the Maintenance of B-Cell Tolerance

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
Room: Longs/Grays Peak

Speaker 4 of 9
Alberto Martin, University of Toronto, Canada
Genome-Wide Screen Identifies kin17 as a Factor Required for Immunoglobulin Class Switch Recombination

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
Room: Longs/Grays Peak

Speaker 5 of 9
Javier M. Di Noia, Institut de Recherches Cliniques de Montreal, Canada
An Atypical Dominant-Negative Effect of Truncated AID Variants on Isotype Switching Explains the Autosomal Dominant HIGM2 Syndrome

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
Room: Longs/Grays Peak

Speaker 6 of 9
Carla R. Nowosad, Rockefeller University, USA
Determining the Architecture and Function of Immune Synapses within B Cell Populations

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
Room: Longs/Grays Peak

Speaker 7 of 9
Mark R. Boothby, Vanderbilt University Medical Center, USA
Signaling Pathways in B Cell Survival and Humoral Memory

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
Room: Longs/Grays Peak

Speaker 8 of 9
Isabelle Robert, Institute of Genetics and Molecular and Cellular Biology, France
Immunoglobulin Class Switch Recombination Is Negatively Regulated by Parp3

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 2: B Cell Activation and Control of B Cell Response
s
Room: Longs/Grays Peak

Speaker 9 of 9
Pia Dosenovic, Karolinska Institutet, Sweden
Slc15a4 Function in Plasmacytoid Dendritic Cells Is Required for in vivo Class Switch Recombination to IgG2c in Response to CpGA

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
Room: Quandary Peak

Speaker 1 of 9
* Nicole Baumgarth, University of California, Davis, USA

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
Room: Quandary Peak

Speaker 2 of 9
Roberto DiNiro, University of Pittsburgh, USA
The B Cell Response to Salmonella typhimurium: Promiscuous B Cell Recruitment for Early Ab Followed by Extrafollicular Affinity Maturation

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
Room: Quandary Peak

Speaker 3 of 9
Rebecca A. Elsner, University of Pittsburgh, USA
The Lyme Disease Agent B. burgdorferi Inhibits Immunological Memory Formation by Suppressing Functional Germinal Center Responses

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
Room: Quandary Peak

Speaker 4 of 9
Eliver Eid Bou Ghosn, Emory University, USA
HSC-Independent Development of Antigen-Specific B-1a Memory

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
Room: Quandary Peak

Speaker 5 of 9
E. Ashley Moseman, NINDS, National Institutes of Health, USA
Adoptive B Cell Immunotherapy Accelerates Control of Chronic Viral Infection

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
Room: Quandary Peak

Speaker 6 of 9
Noel T. Pauli, Adimab LLC, USA
Staphylococcus aureus Infection Induces Affinity Maturation Derived Protein A-Mediated Immune Evasion in Humans

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
Room: Quandary Peak

Speaker 7 of 9
Kristin M.S. Schroeder, National Jewish Health, USA
Characterizing the HIV Envelope Antibody Response by Marginal Zone B Cells

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
Room: Quandary Peak

Speaker 8 of 9
Cristina Gil-Cruz, Kantonsspital St.Gallen, Switzerland
MyD88 Dependent Signals on FRC-Like Cells on Peyer's Patches Control Immune Responses against Pathogens

Tuesday, February 11 | 2:30PM - 4:30PM
Workshop 3: B Cell Responses to Foreign Antigens
Room: Quandary Peak

Speaker 9 of 9
Adnan R. Khan, UCB Celltech, UK
'The Breg Gets the Worm:' How Helminths Can Shed a Light on Regulatory B Cells

Tuesday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 11 | 5:00PM - 7:15PM
B Cell Responses to Foreign Antigens
Room: Longs/Grays Peaks

Speaker 1 of 5
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
B Cell Memory to Infection

Tuesday, February 11 | 5:00PM - 7:15PM
B Cell Responses to Foreign Antigens
Room: Longs/Grays Peaks

Speaker 2 of 5
* Patrick C. Wilson, University of Chicago, USA
B Cell Immunity to Influenza in Humans

Tuesday, February 11 | 5:00PM - 7:15PM
B Cell Responses to Foreign Antigens
Room: Longs/Grays Peaks

Speaker 3 of 5
Hedda Wardemann, German Cancer Research Center, Germany
B Cell Clonal Selection

Tuesday, February 11 | 5:00PM - 7:15PM
B Cell Responses to Foreign Antigens
Room: Longs/Grays Peaks

Speaker 4 of 5
Scott D. Boyd, Stanford University, USA
Short Talk: Convergent Antibodies Are a Hallmark of Influenza Vaccine Seroconversion

Tuesday, February 11 | 5:00PM - 7:15PM
B Cell Responses to Foreign Antigens
Room: Longs/Grays Peaks

Speaker 5 of 5
Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Short Talk: The Multifaceted Role of Il-21r/Stat3 Signaling in Regulating Humoral Immunity and Memory in Humans

Tuesday, February 11 | 5:00PM - 7:00PM
Overcoming Challenging Indications for Antibody Therapeutics
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 1 of 5
* Margaret Karow, Akrevia Therapeutics, USA


Tuesday, February 11 | 5:00PM - 7:00PM
Overcoming Challenging Indications for Antibody Therapeutics
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 2 of 5
Bruce L. Roberts, Vedanta Biosciences, USA
New Insights into the Mechanism of Action of Alemtuzumab


Tuesday, February 11 | 5:00PM - 7:00PM
Overcoming Challenging Indications for Antibody Therapeutics
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 3 of 5
Ronald A. Ignotz, University of Massachusetts Medical School, USA
Short Talk: Topical Anti-TNF-alpha Antibody Enhances Wound Healing in Diabetic Mice


Tuesday, February 11 | 5:00PM - 7:00PM
Overcoming Challenging Indications for Antibody Therapeutics
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 4 of 5
Andreas Grauer, Amgen, USA
Targeting Osteoporosis: Increasing Bone Strength with Antibodies against RANK-L
and Sclerostin


Tuesday, February 11 | 5:00PM - 7:00PM
Overcoming Challenging Indications for Antibody Therapeutics
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 5 of 5
Ronald B. DeMattos, Lilly Research Laboratories, USA
Engaging the Enemy: Improving the Efficacy of Anti- beta-Amyloid Antibodies


Tuesday, February 11 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys


Tuesday, February 11 | 7:30PM - 10:00PM
Poster Session 2
Room: Red Cloud/Shavano/Torreys


Wednesday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
Room: Longs/Grays Peaks

Speaker 1 of 7
Marc K. Jenkins, University of Minnesota Medical School, USA
Origins of CD4+ Effector and Memory T Cells during Bacterial Infection

Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
Room: Longs/Grays Peaks

Speaker 2 of 7
Michael G. McHeyzer-Williams, The Scripps Research Institute, USA
Intra-Clonal Analysis of B Cell Memory

Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
Room: Longs/Grays Peaks

Speaker 3 of 7
Carola G. Vinuesa, Australian National University, Australia
Novel Mechanisms Controlling Mouse and Human Follicular T Cell Homeostasis

Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
Room: Longs/Grays Peaks

Speaker 4 of 7
Shane Crotty, La Jolla Institute for Immunology, USA
T Cell Help to B Cells: Differentiation and Function of Follicular Helper CD4 T Cells (Tfh)

Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
Room: Longs/Grays Peaks

Speaker 5 of 7
* Hai Qi, Tsinghua University, China
Short Talk: Short-Lived T-B Entanglement in the Germinal Center and the Generation of High-Affinity BM Plasma Cells

Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
Room: Longs/Grays Peaks

Speaker 6 of 7
Hui Hu, University of Alabama at Birmingham, USA
Short Talk: Foxp1 Is a Rate-Limiting and Essential Negative Regulator of TFH Cell Differentiation

Wednesday, February 12 | 8:00AM - 11:30AM
Regulating B Cell Immunity
Room: Longs/Grays Peaks

Speaker 7 of 7
Andre Ballesteros-Tato, University of Alabama at Birmingham, USA
Short Talk: FoxP3+ Regulatory T Cells Promote Influenza-Specific Tfh Cell Responses in vivo by Regulating IL-2

Wednesday, February 12 | 8:00AM - 11:00AM
Prophylaxis versus Therapeutic Treatment of Infectious Disea
se
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 1 of 5
* Michael A. Barry, Mayo Clinic, USA


Wednesday, February 12 | 8:00AM - 11:00AM
Prophylaxis versus Therapeutic Treatment of Infectious Disea
se
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 2 of 5
Arturo Casadevall, Albert Einstein College of Medicine, USA
A New Synthesis for Antibody-Mediated Immunity


Wednesday, February 12 | 8:00AM - 11:00AM
Prophylaxis versus Therapeutic Treatment of Infectious Disea
se
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 3 of 5
Deborah C. Molrine, University of Massachusetts Medical School, USA
Antibody Mixtures: Treating Clostridium difficile with an Antibody Combination


Wednesday, February 12 | 8:00AM - 11:00AM
Prophylaxis versus Therapeutic Treatment of Infectious Disea
se
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 4 of 5
Charles Ken Stover, MedImmune, LLC, USA
A Novel Multi-Mechanistic Monoclonal Antibody for Treating P. aeruginosa Infections


Wednesday, February 12 | 8:00AM - 11:00AM
Prophylaxis versus Therapeutic Treatment of Infectious Disea
se
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 5 of 5
Gene Tan, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Characterization of a Broadly Neutralizing Monoclonal Antibody that Targets the Fusion Domain of the Group 2 Hemagglutinin of Influenza A Virus


Wednesday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 12 | 11:30AM - 1:00PM
Poster Setup
Room: Red Cloud/Shavano/Torreys


Wednesday, February 12 | 11:30AM - 2:30PM
On Own for Lunch and Recreation


Wednesday, February 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Red Cloud/Shavano/Torreys


Wednesday, February 12 | 2:00PM - 4:30PM
Workshop 2: When an Antibody Isn't Enough
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 1 of 6
* Hilde Revets, Ablynx, Belgium


Wednesday, February 12 | 2:00PM - 4:30PM
Workshop 2: When an Antibody Isn't Enough
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 2 of 6
Barbara S. Fox, Tilos Therapeutics, Inc., USA
AVX-470: A Novel Orally-Delivered Polyclonal Anti-TNF Antibody Designed to Work Locally in the GI Tract


Wednesday, February 12 | 2:00PM - 4:30PM
Workshop 2: When an Antibody Isn't Enough
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 3 of 6
Anthony B. Cooper, Adimab, LLC, USA
Non-Viral Adeno Associated Virus-Based Platform for Stable Expression of Antibody Combination Therapeutics


Wednesday, February 12 | 2:00PM - 4:30PM
Workshop 2: When an Antibody Isn't Enough
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 4 of 6
Rastislav Tamaskovic, University of Zürich, Switzerland
Intermolecular Trapping of ErbB2 Receptor Disables ErbB Signaling Network and Induces Apoptosis in ErbB2-Addicted Tumors


Wednesday, February 12 | 2:00PM - 4:30PM
Workshop 2: When an Antibody Isn't Enough
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 5 of 6
Kipp Weiskopf, Stanford University, USA
High-Affinity SIRPalpha Variants Enhance Macrophage Destruction of Small Cell Lung Cancer


Wednesday, February 12 | 2:00PM - 4:30PM
Workshop 2: When an Antibody Isn't Enough
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 6 of 6
Nicholas J. Veomett, Weill Cornell Medical College, USA
Targeting the Intracellular WT1 Oncoprotein with Multiple Therapeutic Antibody Modalities


Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
Room: Longs/Grays Peaks

Speaker 1 of 10
* Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Germany

Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
Room: Longs/Grays Peaks

Speaker 2 of 10
* Stuart G. Tangye, Garvan Institute of Medical Research, Australia

Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
Room: Longs/Grays Peaks

Speaker 3 of 10
Jean-Nicolas Schickel, Adimab, LLC, USA
Expanded VH4-34+IgG+ Memory B Cells in IRAK-4 and MyD88-Deficient and SLE Patients Recognize Commensal Bacteria

Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
Room: Longs/Grays Peaks

Speaker 4 of 10
Alexander Frühwirth, Institute for Research in Biomedicine, Switzerland
Identification of a Marker for Recently Activated Memory B Cells

Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
Room: Longs/Grays Peaks

Speaker 5 of 10
Pierre J. Milpied, The Scripps Research Institute, USA
Intraclonal Analysis of Memory B Cell Functional Plasticity

Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
Room: Longs/Grays Peaks

Speaker 6 of 10
Justin J. Taylor, Fred Hutchinson Cancer Research Center, USA
Analysis of the Differentiation of a Single Antigen-Specific Naïve B Cell Early in the Primary Response

Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
Room: Longs/Grays Peaks

Speaker 7 of 10
Niklas Engels, Georg August University Goettingen, Germany
The Immunoglobulin Tail Tyrosine in Surface IgG Promotes T Cell Independent Reactivation of IgG-Switched Memory B Cells

Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
Room: Longs/Grays Peaks

Speaker 8 of 10
Tyani D. Chan, Garvan Institute of Medical Research, Australia
Novel Regulatory Control of IgE Antibody Responses

Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
Room: Longs/Grays Peaks

Speaker 9 of 10
Kathryn A. Pape, University of Minnesota, USA
Generation of IgA Plasma Cells during a Secondary Response in the Absence of IgA Memory B Cells

Wednesday, February 12 | 2:30PM - 4:30PM
Workshop 5: B Cell Memory
Room: Longs/Grays Peaks

Speaker 10 of 10
Kaval Kaur, Agency for Science, Technology and Research, Singapore
SLE Patients Make Higher Affinity Antibody Responses to Influenza Vaccination

Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
Room: Castle Peaks

Speaker 1 of 11
* Ann M. Haberman, Yale University School of Medicine, USA

Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
Room: Castle Peaks

Speaker 2 of 11
* Takaharu Okada, RIKEN, Japan

Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
Room: Castle Peaks

Speaker 3 of 11
Simon N. Willis, Walter and Eliza Hall Institute, Australia
Transcription Factor IRF4 Regulates Germinal Center Cell Formation through a B Cell-Intrinsic Mechanism

Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
Room: Castle Peaks

Speaker 4 of 11
Peter Sage, Harvard Medical School, USA
Specialization of Memory-Like Circulating T Follicular Helper and T Follicular Regulatory Cells

Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
Room: Castle Peaks

Speaker 5 of 11
Michela Locci, University of Pennsylvania, USA
Human Blood CXCR5+ PD-1+CXCR3- CD4 T Cells Are Highly Functional Circulating Memory Tfh Cells

Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
Room: Castle Peaks

Speaker 6 of 11
Tharu M. Fernando, Genentech, Inc., USA
Heat Shock Factor 1 Induces BCL6 to Mediate Stress Tolerance

Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
Room: Castle Peaks

Speaker 7 of 11
Seung Goo Kang, Kangwon National University, South Korea
Essential Roles of miR-17~92 Family miRNAs in Regulating Lymphoid Effector Programs

Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
Room: Castle Peaks

Speaker 8 of 11
Florian Weisel, University of Pittsburgh, USA
A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
Room: Castle Peaks

Speaker 9 of 11
Alexander D. Gitlin, Rockefeller University, USA
Cellular Dynamics Underlying Selection of B Cells in the Germinal Center

Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
Room: Castle Peaks

Speaker 10 of 11
Roy Ramiscal, John Curtin School of Medical Research, Australian National University, Australia
Germinal Center T Follicular Helper Cells Are a Metabolically Distinct Subset of Effector T Cells

Wednesday, February 12 | 2:30PM - 4:45PM
Workshop 4: Follicular Helpers and Germinal Center Biology
Room: Castle Peaks

Speaker 11 of 11
Ziv Shulman, Weizmann Institute, Israel
Prolonged T Follicular Helper Cell Calcium Mobilization during B Cell Selection in Germinal Centers

Wednesday, February 12 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 12 | 5:00PM - 7:15PM
Germinal Center Biology
Room: Longs/Grays Peaks

Speaker 1 of 5
David M. Tarlinton, Monash University, Australia
The Impact of Arginine Methylation on B-Cell Responsiveness

Wednesday, February 12 | 5:00PM - 7:15PM
Germinal Center Biology
Room: Longs/Grays Peaks

Speaker 2 of 5
Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
The Ins and Outs of Germinal Centers: Selection, Generation and Identity

Wednesday, February 12 | 5:00PM - 7:15PM
Germinal Center Biology
Room: Longs/Grays Peaks

Speaker 3 of 5
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Germinal Center Biology

Wednesday, February 12 | 5:00PM - 7:15PM
Germinal Center Biology
Room: Longs/Grays Peaks

Speaker 4 of 5
* Gabriel D. Victora, Rockefeller University, USA
Short Talk: T Follicular Helper Cell Dynamics in Germinal Centers

Wednesday, February 12 | 5:00PM - 7:15PM
Germinal Center Biology
Room: Longs/Grays Peaks

Speaker 5 of 5
Roger Sciammas, University of California, Davis, USA
Short Talk: Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4

Wednesday, February 12 | 5:00PM - 7:15PM
In vivo Induction of Therapeutic Antibodies for Prophylactic
Treatment of Disease
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 1 of 5
* Peter M. Palese, Icahn School of Medicine at Mount Sinai, USA
Redirecting the Immune Response of the Influenza Virus Hemagglutinin to the Conserved Stalk of the Hemagglutinin and Neuraminidase


Wednesday, February 12 | 5:00PM - 7:15PM
In vivo Induction of Therapeutic Antibodies for Prophylactic
Treatment of Disease
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 2 of 5
Ronald G. Crystal, Weill Medical College of Cornell University, USA
Viral Vectors as Platforms for Anti-Addiction Vaccines


Wednesday, February 12 | 5:00PM - 7:15PM
In vivo Induction of Therapeutic Antibodies for Prophylactic
Treatment of Disease
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 3 of 5
Lélia Delamarre, Genentech, Inc., USA
Antibody-Mediated Antigen Delivery for Vaccine Antigens to Dendritic Cells


Wednesday, February 12 | 5:00PM - 7:15PM
In vivo Induction of Therapeutic Antibodies for Prophylactic
Treatment of Disease
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 4 of 5
Seleeke F. Flingai, University of Pennsylvania, USA
Short Talk: Generation of DNA Plasmid-Encoded Broadly Neutralizing Antibodies in vivo


Wednesday, February 12 | 5:00PM - 7:15PM
In vivo Induction of Therapeutic Antibodies for Prophylactic
Treatment of Disease
This session is from Antibodies as Drugs

Room: Quandary Peak

Speaker 5 of 5
Erin Crossey, University of New Mexico, USA
Short Talk: Generation of a Cholesterol-Lowering Vaccine that Targets PCSK9


Wednesday, February 12 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys


Wednesday, February 12 | 7:30PM - 10:00PM
Poster Session 3
Room: Red Cloud/Shavano/Torreys


Thursday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Red Cloud/Shavano/Torreys


Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 1 of 7
Max D. Cooper, Emory University, USA
Immune System Ontogeny and Phylogeny

Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 2 of 7
David G. Schatz, Yale University School of Medicine, USA
Targeting of V(D)J Recombination and Somatic Hypermutation

Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 3 of 7
Cristina Rada, MRC Laboratory of Molecular Biology, UK
Ig Gene Mutagenesis

Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 4 of 7
Frederick W. Alt, Boston Children's Hospital, USA
Role of Target Sequences in Frequency and Outcome of AID-Initiated Mutational and Deletional Events

Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 5 of 7
* F. Nina Papavasiliou, Deutsches Krebsforschungszentrum, Germany
Short Talk: Generation of Diversity: Beyond Genomic Changes

Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 6 of 7
Changchun Xiao, The Scripps Research Institute, USA
Short Talk: MicroRNA-17~92 Plays a Causative Role in Lymphomagenesis by Coordinating Multiple Oncogenic Pathways

Thursday, February 13 | 8:00AM - 11:30AM
Generation of Diversity (Joint)
Room: Longs/Grays Peaks

Speaker 7 of 7
Carol E. Schrader, University of Massachusetts, USA
Short Talk: The Effect of AP Endonuclease on Somatic Hypermutation of IgH Variable Region Genes

Thursday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 13 | 11:30AM - 2:30PM
On Own for Lunch and Recreation


Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 1 of 7
* Peter Brams, Zai Lab, USA


Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 2 of 7
Fabricio Montalvao, Institut Pasteur, France
The Mechanism of Anti-CD20-Mediated B-Cell Depletion Revealed by Intravital Imaging


Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 3 of 7
Karin A. van Schie, Sanquin Research, University of Amsterdam, Netherlands
Anti-Drug Antibodies to All Anti-TNFalpha Therapeutic Antibodies Are Largely Neutralizing


Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 4 of 7
Nancy E. Everds, Amgen, Inc, USA
Off-Target Effects of Therapeutic mAbs on Peripheral Blood Cells


Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 5 of 7
Stefan Barghorn, AbbVie, Inc., Germany
Off Target Toxicity of an Anti-Amyloid Beta Antibody for Alzheimer's Disease Immunotherapy


Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 6 of 7
Mark J. Kwakkenbos, AIMM Therapeutics, Netherlands
In vitro B Cell Affinity Maturation Selects for Antibodies with Increased Neutralizing Activity and Stability


Thursday, February 13 | 2:00PM - 4:30PM
Workshop 3: What We Are Learning about Antibody Therapeutics
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 7 of 7
Nathan J. Alves, Indiana University, USA
Advancing Antibody Targeted Therapies through Site-Specific UV Conjugation of Functional Ligands to the Conserved Antibody Nucleotide Binding Site (NBS)


Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
Room: Longs/Grays Peaks

Speaker 1 of 9
* Eric Meffre, Yale University School of Medicine, USA

Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
Room: Longs/Grays Peaks

Speaker 2 of 9
Nobuo Sakaguchi, Kumamoto University, Japan
GANP Plays a Regulatory Role in the Choice of DNA Repair Pathway by Dissociating DNA-PKcs in AID-Induced Immunoglobulin V-Region Diversification

Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
Room: Longs/Grays Peaks

Speaker 3 of 9
Wai Yen Alfred Lim, MRC Laboratory of Molecular Biology, UK
Directed Evolution of scFvs Using the Hypermutating DT40 B-Cell Line

Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
Room: Longs/Grays Peaks

Speaker 4 of 9
Xiaohua Wang, Asclepius Therapy, USA
A Source of the Single-Stranded DNA Substrate for Activation-Induced Deaminase during Somatic Hypermutation

Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
Room: Longs/Grays Peaks

Speaker 5 of 9
Amanda C. Drennan, University of Wisconsin, Madison, USA
Canonical and Non-Canonical JAK1 Signaling in Diffuse Large B-Cell Lymphoma

Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
Room: Longs/Grays Peaks

Speaker 6 of 9
Virginia G. de Yébenes, Centro Nacional de Investigaciones Cardiovasculares, Spain
miR-217 Is an Oncogene that Enhances the Germinal Center Reaction

Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
Room: Longs/Grays Peaks

Speaker 7 of 9
Daniel Gadala-Maria, Yale University, USA
Genotyping Methods for Improving Detection of Immunoglobulin Mutations

Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
Room: Longs/Grays Peaks

Speaker 8 of 9
Adrienne Greenough, Duke University, USA
Identifying the Landscape of Genetic Alterations in the Lymphoma Transcriptome

Thursday, February 13 | 2:30PM - 4:30PM
Workshop 6: Ig Diversity and Biology of B Cell Tumors
Room: Longs/Grays Peaks

Speaker 9 of 9
Sébastien Storck, Institut Necker-Enfants Malades, France
AID Expression Restricted to the G1 Phase of the Cell Cycle Recapitulates the Mutation Spectrum of Immunoglobulin Genes

Thursday, February 13 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 13 | 5:00PM - 7:15PM
B Cell Cancer Biology
Room: Longs/Grays Peaks

Speaker 1 of 5
Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
Modeling B Cell Lymphomagenesis in Mice

Thursday, February 13 | 5:00PM - 7:15PM
B Cell Cancer Biology
Room: Longs/Grays Peaks

Speaker 2 of 5
Louis M. Staudt, NCI, National Institutes of Health, USA
Therapies Targeting Pathological Signaling in B Cell Lymphomas

Thursday, February 13 | 5:00PM - 7:15PM
B Cell Cancer Biology
Room: Longs/Grays Peaks

Speaker 3 of 5
Riccardo Dalla-Favera, Columbia University, USA
Molecular Genetics of Diffuse Large B Cell Lymphoma

Thursday, February 13 | 5:00PM - 7:15PM
B Cell Cancer Biology
Room: Longs/Grays Peaks

Speaker 4 of 5
* Ralf Küppers, University of Duisburg-Essen, Medical School, Germany
Short Talk: Aspects of the Pathogenesis of Hodgkin Lymphoma

Thursday, February 13 | 5:00PM - 7:15PM
B Cell Cancer Biology
Room: Longs/Grays Peaks

Speaker 5 of 5
Uttiya Basu, USA
Short Talk: Noncoding RNA Processing Promotes AID Targeting to the B Cell Genome

Thursday, February 13 | 5:00PM - 7:00PM
What We've Learned from Antibody Treatment of Inflammation
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 1 of 4
* Neil Graham, Regeneron Pharmaceuticals, USA


Thursday, February 13 | 5:00PM - 7:00PM
What We've Learned from Antibody Treatment of Inflammation
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 2 of 4
Meena Subramanyam, Biogen Idec, USA
Immunogenicity of Monoclonal Antibody Therapeutics: Experiences and Lessons Learned


Thursday, February 13 | 5:00PM - 7:00PM
What We've Learned from Antibody Treatment of Inflammation
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 3 of 4
Neil Graham, Regeneron Pharmaceuticals, USA
Lessons Learned in the Therapeutic Blockade of Th2 Inflammation in Asthma and Atopic Dermatitis Culminating in Dupilumab, a blocker of IL4 Receptor


Thursday, February 13 | 5:00PM - 7:00PM
What We've Learned from Antibody Treatment of Inflammation
This session is from Antibodies as Drugs
Room: Quandary Peak

Speaker 4 of 4
Thomas A. Waldmann, National Institutes of Health, USA
What We Are Still Learning about Anti-CD25 Therapy after 25 Years with Daclizumab


Thursday, February 13 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Red Cloud/Shavano/Torreys


Thursday, February 13 | 8:00PM - 11:00PM
Entertainment
Room: Red Cloud/Shavano/Torreys


Thursday, February 13 | 8:00PM - 11:00PM
Cash Bar
Room: Red Cloud/Shavano/Torreys


Friday, February 14 | 10:25AM - 10:25AM
Departure


*Session Chair.