Web Desc
The Chemistry and Biology of Cell Death
joint with Mitochondrial Dynamics and Physiology
Organizer(s): Guy S. Salvesen, Matthew S. Bogyo and Jennie R. Lill
Date: February 18 - 23, 2014
Location: Santa Fe Community Convention Center, Santa Fe, NM, USA
Sponsored by Genentech, Inc. and Infinity Pharmaceuticals, Inc.
Summary of Meeting:
Cell death can occur through distinct mechanisms, and the signaling pathways leading to these lethal outcomes are becoming established. Although therapeutic strategies targeting specific cell death mediators were introduced over 10 years ago, the breadth of cell death mechanisms should present numerous additional possibilities for drug development. To better understand the Achilles’ heels for targeted therapy, we need to comprehend the chemistry behind cell death paradigms. Coupling the breadth of chemical biology with genetic analysis of cell death pathways in model organisms should provide not only a comprehensive understanding, but reveal tractable targets. This meeting will address the normal regulation and pathogenic dysfunction of distinct cell death modalities, discuss new modalities for therapeutic intervention and highlight chemical biology efforts that are leading to a better understanding of the role that cell death plays in health and disease. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on “Mitochondrial Dynamics and Physiology,” which will share keynote addresses and a plenary session with this meeting.
Scholarship Deadline: October 17 2013
Discounted Abstract Deadline: October 17 2013
Abstract Deadline: November 21 2013
Discounted Registration Deadline: December 17 2013
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Genentech, Inc.Infinity Pharmaceuticals, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Amgen Inc.

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Biochemical Society / Biochemical Journal
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 18 | 4:00PM - 8:00PM
Arrival and Registration
Room: Sweeney Ballroom Foyer


Wednesday, February 19 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Wednesday, February 19 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 4
* Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA

Wednesday, February 19 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 4
* Rodrigue Rossignol, University of Bordeaux, France

Wednesday, February 19 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 4
Vishva M. Dixit, Genentech, Inc., USA
Signaling Lessons from Death Receptors: The Inflammasome and Beyond

Wednesday, February 19 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 4
Jodi Nunnari, University of California, Davis, USA
The Behavior of Mitochondria

Wednesday, February 19 | 10:00AM - 10:20AM
Coffee Break
Room: Sweeney F, Main Level Breakouts


Wednesday, February 19 | 10:20AM - 12:00PM
Mitochondria and Death (Joint)
Room: Sweeney Ballroom A-E

Speaker 1 of 6
* Sally A. Kornbluth, Duke University Medical Center, USA

Wednesday, February 19 | 10:20AM - 12:00PM
Mitochondria and Death (Joint)
Room: Sweeney Ballroom A-E

Speaker 2 of 6
* Heidi M. McBride, McGill University, Canada

Wednesday, February 19 | 10:20AM - 12:00PM
Mitochondria and Death (Joint)
Room: Sweeney Ballroom A-E

Speaker 3 of 6
David W. Andrews, Sunnybrook Research Institute, Canada
Shedding Light on the Mechanisms of Action of Bcl-2 Family Proteins

Wednesday, February 19 | 10:20AM - 12:00PM
Mitochondria and Death (Joint)
Room: Sweeney Ballroom A-E

Speaker 4 of 6
Richard J. Youle, NINDS, National Institutes of Health, USA
Damage Control - How the Pink1/Parkin Pathway Can Regulate Removal of Impaired Mitochondria by Autophagy

Wednesday, February 19 | 10:20AM - 12:00PM
Mitochondria and Death (Joint)
Room: Sweeney Ballroom A-E

Speaker 5 of 6
Dhyan Chandra, Roswell Park Comprehensive Cancer Center, USA
Short Talk: Macromolecular Changes on Mitochondria and their Impact on DNA Damage-Induced Apoptotic Cell Death

Wednesday, February 19 | 10:20AM - 12:00PM
Mitochondria and Death (Joint)
Room: Sweeney Ballroom A-E

Speaker 6 of 6
Luca Scorrano, University of Padova, Italy
Role of Mitochondrial Dynamics in Embryogenesis

Wednesday, February 19 | 12:00PM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakouts


Wednesday, February 19 | 12:00PM - 5:00PM
On Own for Lunch and Recreation


Wednesday, February 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakouts


Wednesday, February 19 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakouts


Wednesday, February 19 | 5:00PM - 7:00PM
Fundamental Death Mechanisms
Room: Sweeney Ballroom D-E

Speaker 1 of 4
* John Silke, Walter and Eliza Hall Institute of Medical Research, Australia

Wednesday, February 19 | 5:00PM - 7:00PM
Fundamental Death Mechanisms
Room: Sweeney Ballroom D-E

Speaker 2 of 4
Douglas R. Green, St. Jude Children's Research Hospital, USA
Apoptotic and Non-Apoptotic Developmental Cell Death in Mice

Wednesday, February 19 | 5:00PM - 7:00PM
Fundamental Death Mechanisms
Room: Sweeney Ballroom D-E

Speaker 3 of 4
Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
The Role of the BCL-2 Regulated (Mitochondrial) Apoptotic Pathway in Morphogenesis during Mouse Development

Wednesday, February 19 | 5:00PM - 7:00PM
Fundamental Death Mechanisms
Room: Sweeney Ballroom D-E

Speaker 4 of 4
Peter E. Czabotar, Walter and Eliza Hall Institute of Medical Research, Australia
Crystal Structures of Bax and Bak Reveal Molecular Events Initiating Apoptosis

Wednesday, February 19 | 5:00PM - 7:00PM
Mitochondrial Architecture
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 1 of 5
* David C. Chan, California Institute of Technology, USA


Wednesday, February 19 | 5:00PM - 7:00PM
Mitochondrial Architecture
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 2 of 5
Nikolaus Pfanner, University of Freiburg, Germany
Biogenesis and Architecture of Mitochondria


Wednesday, February 19 | 5:00PM - 7:00PM
Mitochondrial Architecture
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 3 of 5
Thomas Langer, CECAD Research Center, Germany
Proteolytic Control of Mitochondrial Membrane Dynamics


Wednesday, February 19 | 5:00PM - 7:00PM
Mitochondrial Architecture
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 4 of 5
Peter Rehling, University Medical Centre Göttingen, Germany
Biogenesis of Mitochondrial Membrane Protein Complexes


Wednesday, February 19 | 5:00PM - 7:00PM
Mitochondrial Architecture
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 5 of 5
Victoria L. Hewitt, Medical Research Council, UK
Short Talk: The Role of SAM and ERMES Complexes in Candida albicans Mitochondria


Wednesday, February 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts


Wednesday, February 19 | 7:30PM - 10:00PM
Poster Session 1
Room: Sweeney F, Main Level Breakouts


Thursday, February 20 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Thursday, February 20 | 7:30AM - 8:00AM
Poster Setup
Room: Sweeney F, Main Level Breakouts


Thursday, February 20 | 8:00AM - 7:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakouts


Thursday, February 20 | 8:00AM - 11:00AM
Chemical Biology
Room: Sweeney Ballroom D-E

Speaker 1 of 7
* Jennie R. Lill, Genentech, Inc., USA

Thursday, February 20 | 8:00AM - 11:00AM
Chemical Biology
Room: Sweeney Ballroom D-E

Speaker 2 of 7
Mark B. Hampton, University of Otago, New Zealand
Reactive Oxygen Species and Cell Death

Thursday, February 20 | 8:00AM - 11:00AM
Chemical Biology
Room: Sweeney Ballroom D-E

Speaker 3 of 7
Brent R. Stockwell, Columbia University, USA
Probing Cell Death with Small Molecules

Thursday, February 20 | 8:00AM - 11:00AM
Chemical Biology
Room: Sweeney Ballroom D-E

Speaker 4 of 7
Matthew S. Bogyo, Stanford University School of Medicine, USA
A Chemical Biology Approach for the Selective Imaging and Inhibition of Caspases

Thursday, February 20 | 8:00AM - 11:00AM
Chemical Biology
Room: Sweeney Ballroom D-E

Speaker 5 of 7
Sarah H. MacKenzie, North Carolina State University, USA
Short Talk: A Natural Peptide Binds to an Allosteric Site in Caspase-3

Thursday, February 20 | 8:00AM - 11:00AM
Chemical Biology
Room: Sweeney Ballroom D-E

Speaker 6 of 7
Sharan R. Srinivasan, University of Michigan, USA
Short Talk: Allosteric Inhibitor of Hsp70 Reveals its Role at the Intersection of Multiple Cell Death Pathways

Thursday, February 20 | 8:00AM - 11:00AM
Chemical Biology
Room: Sweeney Ballroom D-E

Speaker 7 of 7
Guillaume Lessene, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Novel, Potent and Selective Inhibitors of the Pro-Survival BCL-2 Family Member BCL-XL

Thursday, February 20 | 8:00AM - 11:00AM
Mitochondrial Dynamics
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 1 of 6
* Jodi Nunnari, University of California, Davis, USA


Thursday, February 20 | 8:00AM - 11:00AM
Mitochondrial Dynamics
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 2 of 6
Heidi M. McBride, McGill University, Canada
The Physiological Implications of Mitochondrial SUMOylation


Thursday, February 20 | 8:00AM - 11:00AM
Mitochondrial Dynamics
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 3 of 6
Gia K. Voeltz, University of Colorado Boulder, USA
Snapshots of ER-Mediated Mitochondrial Constriction Sites


Thursday, February 20 | 8:00AM - 11:00AM
Mitochondrial Dynamics
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 4 of 6
Henry N. Higgs, Geisel School of Medicine at Dartmouth, USA
A Role for Actin, Formins and Myosin II in Mammalian Mitochondrial Fission


Thursday, February 20 | 8:00AM - 11:00AM
Mitochondrial Dynamics
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 5 of 6
Stefan Strack, University of Iowa, USA
Regulation of Mitochondrial Fission in Neuronal Development and Synaptic Plasticity


Thursday, February 20 | 8:00AM - 11:00AM
Mitochondrial Dynamics
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 6 of 6
Robert A. Screaton, Sunnybrook Research Institute, Canada
Short Talk: Genome-Wide RNAi Screen Identifies ROMO1 as an Essential Redox-Dependent Regulator of Mitochondrial Dynamics


Thursday, February 20 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakouts


Thursday, February 20 | 11:00AM - 12:00PM
Lunch
Room: Sweeney F, Main Level Breakouts


Thursday, February 20 | 12:00PM - 2:30PM
Poster Session 2
Room: Sweeney F, Main Level Breakouts


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Autophagy and Mitophagy
Room: Sweeney Ballroom D-E

Speaker 1 of 8
* Lisa M. Lindqvist, Walter and Eliza Hall Institute of Medical Research, Australia
Bcl-2, Bcl-xL and Mcl-1 Are Not Major Regulators of Autophagy

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Autophagy and Mitophagy
Room: Sweeney Ballroom D-E

Speaker 2 of 8
Juliane C. Campos, University of Sao Paulo, Brazil
Disrupted Mitochondrial Dynamics and Impaired Autophagy in Heart Failure: Impact of Exercise Training

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Autophagy and Mitophagy
Room: Sweeney Ballroom D-E

Speaker 3 of 8
Isabella Caniggia, Lunenfeld-Tanenbaum Research Institute, Canada
Disruption of Sphingolipid Metabolism Augments Placental Autophagy

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Autophagy and Mitophagy
Room: Sweeney Ballroom D-E

Speaker 4 of 8
Kelly Sullivan, University of Colorado, USA
Mechanisms of p53-Dependent Cell Fate Choice

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Autophagy and Mitophagy
Room: Sweeney Ballroom D-E

Speaker 5 of 8
Aditya Murthy, Genentech, Inc., USA
A Crohn’s Disease Mutation in the Autophagy Gene Atg16L1 Facilitates its Caspase-Mediated Degradation

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Autophagy and Mitophagy
Room: Sweeney Ballroom D-E

Speaker 6 of 8
Gavin Clive Higgins, Baker IDI Heart and Diabetes Institute, Australia
Impaired Mitophagy Activity in Experimental Diabetic Nephropathy

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Autophagy and Mitophagy
Room: Sweeney Ballroom D-E

Speaker 7 of 8
Malle Kuum, University of Tartu, Estonia
Directed Laser Irradiation-Based Method to Study Selective Mitophagy in Neurons

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Autophagy and Mitophagy
Room: Sweeney Ballroom D-E

Speaker 8 of 8
Baris Bingol, Genentech, Inc., USA
DUBs Regulate the Parkin/PINK1 Mitophagy Pathway

Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Research and Drug Discovery
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 1 of 7
* Thomas Langer, CECAD Research Center, Germany


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Research and Drug Discovery
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 2 of 7
Ying Liu, Peking University, China
Endogenous Small Molecule Signals of C. elegans Mitochondrial Dysfunction Couple to the Induction of Detoxification and Pathogen Response Pathways


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Research and Drug Discovery
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 3 of 7
Bjoern Oettinghaus, University Hospital Basel, Switzerland
Induced Drp1 Ablation in the Adult Mouse Forebrain


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Research and Drug Discovery
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 4 of 7
Melissa Vos, University of Lübeck, Germany
Stimulation of the Electron Transport Chain as a Possible Therapeutic Strategy for Parkinson’s Disease


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Research and Drug Discovery
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 5 of 7
Daniel J. Gonzalez-Dunia, Inserm UMR1043, France
Bornavirus X Protein: A New Tool Against Neurodegenerative Disorders?


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Research and Drug Discovery
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 6 of 7
Simone Caielli, Baylor Institute for Immunology Research, USA
Incomplete Mitophagy in Human Neutrophils Leads to Extrusion of Mitochondrial Nucleoids


Thursday, February 20 | 2:30PM - 4:30PM
Workshop 1: Mitochondrial Research and Drug Discovery
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 7 of 7
Erin Quan Toyama, Genomics Institute of the Novartis Research Foundation, USA
Identification of MFF as a Direct Substrate for AMPK


Thursday, February 20 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakouts


Thursday, February 20 | 5:00PM - 7:00PM
'Deathomics'
Room: Sweeney Ballroom D-E

Speaker 1 of 5
* Matthew S. Bogyo, Stanford University School of Medicine, USA

Thursday, February 20 | 5:00PM - 7:00PM
'Deathomics'
Room: Sweeney Ballroom D-E

Speaker 2 of 5
Jennie R. Lill, Genentech, Inc., USA
Caspase Substrate Discovery

Thursday, February 20 | 5:00PM - 7:00PM
'Deathomics'
Room: Sweeney Ballroom D-E

Speaker 3 of 5
James A. Wells, University of California, San Francisco, USA
Caspase Kinetics

Thursday, February 20 | 5:00PM - 7:00PM
'Deathomics'
Room: Sweeney Ballroom D-E

Speaker 4 of 5
Harris G. Fienberg, Stanford University, USA
Network Rewiring Is Critical for Non-Genetic Resistance to TRAIL

Thursday, February 20 | 5:00PM - 7:00PM
'Deathomics'
Room: Sweeney Ballroom D-E

Speaker 5 of 5
James A. Clulow, Imperial College London, UK
Short Talk: Unravelling the Targets of Electrophilic Natural Products using Quantitative Activity-Based Chemical Proteomics

Thursday, February 20 | 5:00PM - 7:00PM
Mitochondria as Signaling Platform
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 1 of 5
* Andrew G. Dillin, University of California, Berkeley, USA


Thursday, February 20 | 5:00PM - 7:00PM
Mitochondria as Signaling Platform
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 2 of 5
Marcia C. Haigis, Harvard Medical School, USA
Mitochondrial Dynamics in Metabolic Adaptation


Thursday, February 20 | 5:00PM - 7:00PM
Mitochondria as Signaling Platform
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 3 of 5
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
The Mitochondrial Pathway of Antiviral Innate Immune Response


Thursday, February 20 | 5:00PM - 7:00PM
Mitochondria as Signaling Platform
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 4 of 5
David C. Chan, California Institute of Technology, USA
Molecular Regulation of Mitochondrial Dynamics


Thursday, February 20 | 5:00PM - 7:00PM
Mitochondria as Signaling Platform
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 5 of 5
Andrea Rasola, Università degli Studi di Padova, Italy
Short Talk: The Mitochondrial Chaperone TRAP1 and Neoplastic Transformation


Thursday, February 20 | 7:00PM - 7:00PM
On Own for Dinner


Friday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Friday, February 21 | 8:00AM - 11:00AM
Post-Translational Control of Cell Death
Room: Sweeney Ballroom D-E

Speaker 1 of 6
* Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia

Friday, February 21 | 8:00AM - 11:00AM
Post-Translational Control of Cell Death
Room: Sweeney Ballroom D-E

Speaker 2 of 6
John Silke, Walter and Eliza Hall Institute of Medical Research, Australia
cIAPs and Sharpin Regulate TNF/MLKL Dependent Necroptotic Cell Death and Developments in Targeting this Axis in Disease

Friday, February 21 | 8:00AM - 11:00AM
Post-Translational Control of Cell Death
Room: Sweeney Ballroom D-E

Speaker 3 of 6
Henning Walczak, University College London, Cancer Institute, UK
New Traits of TRAIL in Cancer

Friday, February 21 | 8:00AM - 11:00AM
Post-Translational Control of Cell Death
Room: Sweeney Ballroom D-E

Speaker 4 of 6
Marion MacFarlane, MRC Toxicology Unit, UK
Death Receptor Mechanisms: The ‘FLIP’ Side of the DISC

Friday, February 21 | 8:00AM - 11:00AM
Post-Translational Control of Cell Death
Room: Sweeney Ballroom D-E

Speaker 5 of 6
Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
Proteolytic Crosstalk in Cell Death and Survival

Friday, February 21 | 8:00AM - 11:00AM
Post-Translational Control of Cell Death
Room: Sweeney Ballroom D-E

Speaker 6 of 6
Yoshihisa Kaizuka, National Institute for Materials Science, Japan
Short Talk: Signal Protein Clusters in Plasma Membranes Involved in Death Signaling and Adaptive Immunity

Friday, February 21 | 8:00AM - 11:00AM
Quality Control
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 1 of 6
* Richard J. Youle, NINDS, National Institutes of Health, USA


Friday, February 21 | 8:00AM - 11:00AM
Quality Control
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 2 of 6
Cole M. Haynes, University of Massachusetts Medical School, USA
Coordinating Repair and Regeneration of Defective Mitochondrial via the UPRmt


Friday, February 21 | 8:00AM - 11:00AM
Quality Control
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 3 of 6
Jared Rutter, University of Utah, USA
Functionalizing the Unannotated Mitochondrial Proteome


Friday, February 21 | 8:00AM - 11:00AM
Quality Control
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 4 of 6
Dario C. Altieri, Wistar Institute, USA
Mitochondrial Chaperones


Friday, February 21 | 8:00AM - 11:00AM
Quality Control
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 5 of 6
Koji Okamoto, Osaka University, Japan
Targeting Autophagy for Mitochondrial Clearance


Friday, February 21 | 8:00AM - 11:00AM
Quality Control
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 6 of 6
Giovanni Bénard, INSERM, France
Short Talk: Mitochondrial Turnover and Energy Metabolism


Friday, February 21 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakouts


Friday, February 21 | 11:00AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakouts


Friday, February 21 | 11:00AM - 2:30PM
On Own for Lunch and Recreation


Friday, February 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakouts


Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: RIP3/Necroptosis
Room: Sweeney Ballroom D-E

Speaker 1 of 6
* Kim Newton, Genentech, Inc., USA

Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: RIP3/Necroptosis
Room: Sweeney Ballroom D-E

Speaker 2 of 6
Susana L. Orozco, University of Washington, USA
RIPK1 both Positively and Negatively Regulates RIPK3 Oligomerization and Necroptosis.

Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: RIP3/Necroptosis
Room: Sweeney Ballroom D-E

Speaker 3 of 6
Carlos F. Lopez, Vanderbilt University, USA
Exploring how Cells Commit to Apoptotic or Necrotic Cell-Death

Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: RIP3/Necroptosis
Room: Sweeney Ballroom D-E

Speaker 4 of 6
Francis Ka-Ming Chan, Duke University, USA
Necrotic and Non-Necrotic Functions of RIP3 in Injury-Induced Inflammation

Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: RIP3/Necroptosis
Room: Sweeney Ballroom D-E

Speaker 5 of 6
Mordechay Gerlic, Sackler Faculty of Medicine, Tel Aviv University, Israel
RIPK1 Regulates Cell Death Driven Systemic Inflammation

Friday, February 21 | 2:30PM - 4:30PM
Workshop 2: RIP3/Necroptosis
Room: Sweeney Ballroom D-E

Speaker 6 of 6
Edward S. Mocarski, Emory University, USA
Small Molecule RIP3-Kinase Inhibitor-Induced Apoptosis

Friday, February 21 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakouts


Friday, February 21 | 5:00PM - 7:00PM
Death Meets Survival
Room: Sweeney Ballroom D-E

Speaker 1 of 5
* Douglas R. Green, St. Jude Children's Research Hospital, USA

Friday, February 21 | 5:00PM - 7:00PM
Death Meets Survival
Room: Sweeney Ballroom D-E

Speaker 2 of 5
Pamela M. Holland, Alpine Immune Sciences, USA
Death Receptor Agonists for Cancer: Which Is the Right TRAIL?

Friday, February 21 | 5:00PM - 7:00PM
Death Meets Survival
Room: Sweeney Ballroom D-E

Speaker 3 of 5
Marion C. Bonnet, INSERM U976-Hopital St-Louis, France
Death and Survival of Keratinocytes

Friday, February 21 | 5:00PM - 7:00PM
Death Meets Survival
Room: Sweeney Ballroom D-E

Speaker 4 of 5
Kim Newton, Genentech, Inc., USA
Death by Kinases RIP1 and RIP3

Friday, February 21 | 5:00PM - 7:00PM
Death Meets Survival
Room: Sweeney Ballroom D-E

Speaker 5 of 5
Ben A. Croker, Boston Children's Hospital, USA
Short Talk: Fas Controls Neutrophil Lifespan during Viral Infection and Is Negatively Regulated by TLR and IL-18 Signaling

Friday, February 21 | 5:00PM - 7:00PM
Stem Cells and Development
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 1 of 7
* Luca Scorrano, University of Padova, Italy


Friday, February 21 | 5:00PM - 7:00PM
Stem Cells and Development
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 2 of 7
Carla Koehler, University of California, Los Angeles, USA
Correcting Human Mitochondrial Mutations with Targeted RNA Import


Friday, February 21 | 5:00PM - 7:00PM
Stem Cells and Development
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 3 of 7
Jahar Bhattacharya, College of Physicians & Surgeons, Columbia University, USA
Mitochondrial Transfer from Bone-Marrow-Derived Stromal Cells to Pulmonary Alveoli Protects Against Acute Lung Injury


Friday, February 21 | 5:00PM - 7:00PM
Stem Cells and Development
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 4 of 7
Mireille Khacho, University of Ottawa, Canada
Short Talk: Mitochondrial Dynamics in the Regulation of Stem Cell Maintenance and Cell Fate Decisions


Friday, February 21 | 5:00PM - 7:00PM
Stem Cells and Development
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 5 of 7
Alison M. Burkart, Joslin Diabetes Center, USA
Short Talk: Dissecting Relationships between Insulin Resistance and Mitochondrial Metabolism in Human iPS Cells


Friday, February 21 | 5:00PM - 7:00PM
Stem Cells and Development
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 6 of 7
Konstanze F. Winklhofer, Ruhr University Bochum, Germany
Short Talk: Talk Title to be Announced


Friday, February 21 | 5:00PM - 7:00PM
Stem Cells and Development
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 7 of 7
Michael A. Frohman, Stony Brook University, USA
Roles for the Lipid-Signaling Enzymes MitoPLD and Lipin 1 in Mitochondrial Dynamics, piRNA Biogenesis, and Spermatogenesis


Friday, February 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts


Friday, February 21 | 7:30PM - 10:00PM
Poster Session 3
Room: Sweeney F, Main Level Breakouts


Saturday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Saturday, February 22 | 8:00AM - 11:15AM
Leveraging Model Organisms
Room: Sweeney Ballroom D-E

Speaker 1 of 7
* Marion MacFarlane, MRC Toxicology Unit, UK

Saturday, February 22 | 8:00AM - 11:15AM
Leveraging Model Organisms
Room: Sweeney Ballroom D-E

Speaker 2 of 7
Eli Arama, Weizmann Institute of Science, Israel
A Mitochondrial-Based Rate-Limiting Mechanism for Caspase Activation during Sperm Differentiation in Drosophila

Saturday, February 22 | 8:00AM - 11:15AM
Leveraging Model Organisms
Room: Sweeney Ballroom D-E

Speaker 3 of 7
Hyung Don Ryoo, New York University Langone Medical Center, USA
Regulating the Subcellular Distribution of a Pro-Apoptotic Protein, Hid

Saturday, February 22 | 8:00AM - 11:15AM
Leveraging Model Organisms
Room: Sweeney Ballroom D-E

Speaker 4 of 7
Kim McCall, Boston University, USA
Non-Apoptotic Cell Death in Drosophila Oogenesis

Saturday, February 22 | 8:00AM - 11:15AM
Leveraging Model Organisms
Room: Sweeney Ballroom D-E

Speaker 5 of 7
Eric H. Baehrecke, University of Massachusetts Medical School, USA
Regulation and Function of Autophagy during Cell Death

Saturday, February 22 | 8:00AM - 11:15AM
Leveraging Model Organisms
Room: Sweeney Ballroom D-E

Speaker 6 of 7
Keren Yacobi Sharon, Weizmann Institute of Science, Israel
Short Talk: Germ Cell Death: A Physiological Alternative Cell Death Pathway in Drosophila

Saturday, February 22 | 8:00AM - 11:15AM
Leveraging Model Organisms
Room: Sweeney Ballroom D-E

Speaker 7 of 7
Barbara Conradt, Ludwig-Maximilians-Universitat, Germany
Short Talk: C. elegans CED-3 Caspase Regulates Centrosome Asymmetry in an Apoptotic Death

Saturday, February 22 | 8:00AM - 11:00AM
Environmental Control of Mitochondrial Physiology
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 1 of 5
Andrew G. Dillin, University of California, Berkeley, USA
The Conserved Histone Lysine Demethylase PHF8 Regulates Mitochondrial ETC-Mediated Longevity


Saturday, February 22 | 8:00AM - 11:00AM
Environmental Control of Mitochondrial Physiology
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 2 of 5
* Lluis Fajas, Université de Lausanne, Switzerland
Participation of CDK4 in the Regulation of Mitochondrial Metabolism and Energy Homeostasis


Saturday, February 22 | 8:00AM - 11:00AM
Environmental Control of Mitochondrial Physiology
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 3 of 5
Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Lipid Metabolism, Mitochondria, and Memory T Cell Generation


Saturday, February 22 | 8:00AM - 11:00AM
Environmental Control of Mitochondrial Physiology
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 4 of 5
Christian Frezza, Hutchison/MRC Research Centre, UK
Altered Mitochondrial Metabolism in Cancer


Saturday, February 22 | 8:00AM - 11:00AM
Environmental Control of Mitochondrial Physiology
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 5 of 5
Sameer Kulkarni, Nestlè Institute of Health Sciences SA, Switzerland
Short Talk: Impact of Liver-Specific Deletion of Mfn1 and Mfn2 in Metabolic Health


Saturday, February 22 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney F, Main Level Breakouts


Saturday, February 22 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Saturday, February 22 | 2:30PM - 4:30PM
Workshop 2: Emerging Topics in Mitochondrial Dynamics and Ph
ysiology
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 1 of 8
* Cole M. Haynes, University of Massachusetts Medical School, USA


Saturday, February 22 | 2:30PM - 4:30PM
Workshop 2: Emerging Topics in Mitochondrial Dynamics and Ph
ysiology
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 2 of 8
Mariusz Karbowski, University of Maryland School of Medicine, USA
MARCH5-Dependent Regulation of the OMM-Associated Degradation (OMMAD) Pathway and Mitochondrial Steps in Apoptosis


Saturday, February 22 | 2:30PM - 4:30PM
Workshop 2: Emerging Topics in Mitochondrial Dynamics and Ph
ysiology
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 3 of 8
Adam L. Hughes, University of Utah, USA
An Autophagy-Dependent Pathway for Removal of Individual Proteins from Dysfunctional Mitochondria


Saturday, February 22 | 2:30PM - 4:30PM
Workshop 2: Emerging Topics in Mitochondrial Dynamics and Ph
ysiology
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 4 of 8
Noriyuki Matsuda, Tokyo Metropolitan Institute of Medical Science, Japan
Identification of the Genuine Substrate of PINK1 that Activates Parkin


Saturday, February 22 | 2:30PM - 4:30PM
Workshop 2: Emerging Topics in Mitochondrial Dynamics and Ph
ysiology
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 5 of 8
Christof Osman, University of California, San Francisco, USA
Live-Cell Microscopy of Mitochondrial DNA Suggests a Mechanism for its Inheritance and Distribution


Saturday, February 22 | 2:30PM - 4:30PM
Workshop 2: Emerging Topics in Mitochondrial Dynamics and Ph
ysiology
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 6 of 8
A. Phillip West, Yale University School of Medicine, USA
Altered Mitochondrial DNA Dynamics Elicits a Cell-Intrinsic Antiviral Signaling Program


Saturday, February 22 | 2:30PM - 4:30PM
Workshop 2: Emerging Topics in Mitochondrial Dynamics and Ph
ysiology
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 7 of 8
Atsushi Tanaka, Yamagata University, Japan
Mechanisms and Process of Mitochondrial Collapse in Autophagy-Deficient Mice


Saturday, February 22 | 2:30PM - 4:30PM
Workshop 2: Emerging Topics in Mitochondrial Dynamics and Ph
ysiology
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 8 of 8
Brian Alexander Roelofs, University of Maryland Baltimore, USA
Npl4 Is Required for p97 to Perform Mitochondrial Quality Control Functions


Saturday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney F, Main Level Breakouts


Saturday, February 22 | 5:00PM - 7:00PM
Systems Biology and Death Imaging
Room: Sweeney Ballroom D-E

Speaker 1 of 5
* Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA

Saturday, February 22 | 5:00PM - 7:00PM
Systems Biology and Death Imaging
Room: Sweeney Ballroom D-E

Speaker 2 of 5
Peter Sorger, Harvard Medical School, USA
Measuring and Modeling Receptor Mediated Cell Death

Saturday, February 22 | 5:00PM - 7:00PM
Systems Biology and Death Imaging
Room: Sweeney Ballroom D-E

Speaker 3 of 5
Jessie Ochoa, University of California, Santa Cruz, USA
Short Talk: Cytological Profiling of Natural Products to Identify Modes of Action

Saturday, February 22 | 5:00PM - 7:00PM
Systems Biology and Death Imaging
Room: Sweeney Ballroom D-E

Speaker 4 of 5
Sally A. Kornbluth, Duke University Medical Center, USA
Control of Caspase 2 Activation

Saturday, February 22 | 5:00PM - 7:00PM
Systems Biology and Death Imaging
Room: Sweeney Ballroom D-E

Speaker 5 of 5
Pascal Meier, Institute of Cancer Research, UK
Regulation of the Ubiquitin E3 Ligase cIAP1

Saturday, February 22 | 5:00PM - 7:00PM
Mitochondria in Tissue Homeostasis
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 1 of 5
* Jared Rutter, University of Utah, USA


Saturday, February 22 | 5:00PM - 7:00PM
Mitochondria in Tissue Homeostasis
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 2 of 5
Eric A. Shoubridge, McGill University, Canada
Posttranscriptional Regulation of Mitochondrial Gene Expression


Saturday, February 22 | 5:00PM - 7:00PM
Mitochondria in Tissue Homeostasis
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 3 of 5
Rodrigue Rossignol, University of Bordeaux, France
Oncogenic RAS Inhibits the LKB1-AMPK Axis and Repatterns Energy Metabolism


Saturday, February 22 | 5:00PM - 7:00PM
Mitochondria in Tissue Homeostasis
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 4 of 5
Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Mitochondrial Metabolism in Cancer


Saturday, February 22 | 5:00PM - 7:00PM
Mitochondria in Tissue Homeostasis
This session is from Mitochondrial Dynamics
Room: Sweeney Ballroom A-C

Speaker 5 of 5
Dongryeol Ryu, Sungkyunkwan University, South Korea
Short Talk: SIRT7 Regulates Mitochondrial Homeostasis via the Deacetylation and Activation of GABPbeta1


Saturday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts


Saturday, February 22 | 8:00PM - 11:00PM
Entertainment
Room: Sweeney F, Main Level Breakouts


Saturday, February 22 | 8:00PM - 11:00PM
Cash Bar
Room: Sweeney F, Main Level Breakouts


Sunday, February 23 | 10:25AM - 10:25AM
Departure


*Session Chair.