Web Desc
Immune Evolution in Cancer
joint with Inflammation, Infection and Cancer
Organizer(s): Suzanne Ostrand-Rosenberg, Olivera J. Finn and Lisa M. Coussens
Date: March 09 - 14, 2014
Location: Fairmont Chateau Whistler, Whistler, BC, Canada
Sponsored by Bristol-Myers Squibb Company, Genentech, Inc., OncoMed Pharmaceuticals, Inc., Roche and Vertex Pharmaceuticals Incorporated
Summary of Meeting:
Neoplastic progression is initiated by accumulations of somatic mutations in proliferating cells that cause “healthy” cells to sustain survival programs and resist embedded tissue-based programs designed to restrain their unchecked proliferation. Concurrent with neoplastic progression, the immune system sculpts the neoplastic cell repertoire by eliminating immunogenic cells while allowing outgrowth of less immunogenic variants, a process known as immunoediting. As neoplasms undergo early progression, they often resemble a chronic “wound” wherein activated tissue remodeling, and immune and angiogenic programs, facilitate the survival of potentially malignant cells. Cells of the adaptive and innate immune systems are particularly important during wound healing; however, during cancer development, many immune cells are co-opted and effectively “reprogrammed” toward a tumor-promoting phenotype. As a result, malignant cells condition their environment to facilitate their progression by co-opting multiple immune effector cell populations. Presentations at this conference will focus on how the tumor microenvironment perturbs lymphoid and myeloid cells, the mechanisms used by immune cells to promote tumor growth, and the strategies being developed to counteract tumor-induced immune suppression to generate anti-tumor immunity. Many of the tumor-promoting effects of the immune system are regulated by leukocyte infiltration (e.g., chronic inflammation); therefore, this conference, in conjunction with the companion conference on Inflammation, Infection and Cancer, will provide an in-depth examination of the current understanding of tumor progression, and will facilitate interactions between tumor immunologists and cancer biologists.
Scholarship Deadline: November 6 2013
Discounted Abstract Deadline: November 6 2013
Abstract Deadline: December 10 2013
Discounted Registration Deadline: January 9 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bristol-Myers Squibb CompanyGenentech, Inc.OncoMed Pharmaceuticals, Inc.RocheVertex Pharmaceuticals Incorporated
We gratefully acknowledge additional support for this conference from:
Peregrine Pharmaceuticals Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA182664-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 09 | 4:00PM - 8:00PM
Arrival and Registration
Room: MacDonald Foyer


Monday, March 10 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac Ballroom and Foyer


Monday, March 10 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: MacDonald A-F

Speaker 1 of 4
* Johanna A. Joyce, University of Lausanne, Switzerland

Monday, March 10 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: MacDonald A-F

Speaker 2 of 4
* Suzanne Ostrand-Rosenberg, University of Maryland, USA

Monday, March 10 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: MacDonald A-F

Speaker 3 of 4
Robert D. Schreiber, Washington University School of Medicine, USA
Using Genomics to Define Cancer Immunoediting Mechanisms and Inform Cancer Immunotherapy

Monday, March 10 | 8:00AM - 10:00AM
Keynote Session (Joint)
Room: MacDonald A-F

Speaker 4 of 4
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Differentiation and Function of Regulatory T Cells and Cancer

Monday, March 10 | 10:00AM - 10:20AM
Coffee Break
Room: MacDonald Foyer


Monday, March 10 | 10:20AM - 12:15PM
Inflammation and Immunity in the Tumor Microenvironment (Joi
nt)

Room: MacDonald A-F

Speaker 1 of 6
* Timothy C. Wang, Columbia University, USA

Monday, March 10 | 10:20AM - 12:15PM
Inflammation and Immunity in the Tumor Microenvironment (Joi
nt)

Room: MacDonald A-F

Speaker 2 of 6
Andrew J. Dannenberg, Weill Medical College of Cornell University, USA
The Obesity-Inflammation Connection: Implications for Breast Cancer

Monday, March 10 | 10:20AM - 12:15PM
Inflammation and Immunity in the Tumor Microenvironment (Joi
nt)

Room: MacDonald A-F

Speaker 3 of 6
Lisa M. Coussens, Oregon Health & Science University, USA
Impact of Innate and Adaptive Immunity on Cancer-Associated Chronic Inflammation

Monday, March 10 | 10:20AM - 12:15PM
Inflammation and Immunity in the Tumor Microenvironment (Joi
nt)

Room: MacDonald A-F

Speaker 4 of 6
Allison S. Harney, Albert Einstein College of Medicine, USA
Short Talk: Perivascular Macrophages Induce Localized, Transient Blood Vessel Permeability and Tumor Cell Intravasation

Monday, March 10 | 10:20AM - 12:15PM
Inflammation and Immunity in the Tumor Microenvironment (Joi
nt)

Room: MacDonald A-F

Speaker 5 of 6
Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany
Short Talk: Stat3 Controlled Lysosomal Membrane Permeabilization in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumor Initiation

Monday, March 10 | 10:20AM - 12:15PM
Inflammation and Immunity in the Tumor Microenvironment (Joi
nt)

Room: MacDonald A-F

Speaker 6 of 6
Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Macrophage Promotion of Tumor Progression and Metastasis

Monday, March 10 | 12:00PM - 1:00PM
Poster Setup
Room: Frontenac Ballroom and Foyer


Monday, March 10 | 12:15PM - 2:30PM
On Own for Lunch and Recreation


Monday, March 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Frontenac Ballroom and Foyer


Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: High-Throughput Approaches to Analyze and Target
Immune Cell Functions in Cancer (Joint)
Room: MacDonald ABC

Speaker 1 of 9
* Ming O. Li, Memorial Sloan Kettering Cancer Center, USA

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: High-Throughput Approaches to Analyze and Target
Immune Cell Functions in Cancer (Joint)
Room: MacDonald ABC

Speaker 2 of 9
Matthew H. Spitzer, Stanford University, USA
Revealing the Tumor-Immune Network via Single-Cell Mass Cytometry

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: High-Throughput Approaches to Analyze and Target
Immune Cell Functions in Cancer (Joint)
Room: MacDonald ABC

Speaker 3 of 9
Zlatko Trajanoski, Medical University of Innsbruck, Austria
Intratumoral Immune Landscape, Tumor Immunogenicity and Antigenome in Human Colorectal Cancer

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: High-Throughput Approaches to Analyze and Target
Immune Cell Functions in Cancer (Joint)
Room: MacDonald ABC

Speaker 4 of 9
Lisa Sevenich, Institute for Tumor Biology and Experimental Therapy, Germany
A Brain Metastasis-Promoting Role for Cathepsin S Identified from Analysis of Tumor- and Stroma-Supplied Proteolytic Networks

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: High-Throughput Approaches to Analyze and Target
Immune Cell Functions in Cancer (Joint)
Room: MacDonald ABC

Speaker 5 of 9
Neta Erez, Tel Aviv University, Israel
Pro-Inflammatory Signaling by Cancer-Associated Fibroblasts Co-Evolves during Mammary Carcinogenesis

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: High-Throughput Approaches to Analyze and Target
Immune Cell Functions in Cancer (Joint)
Room: MacDonald ABC

Speaker 6 of 9
Kaisa Thorell, Gothenburg University, Sweden
Differential Expression of Kynurenine Pathway Enzymes in Early Stomach Cancer Development

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: High-Throughput Approaches to Analyze and Target
Immune Cell Functions in Cancer (Joint)
Room: MacDonald ABC

Speaker 7 of 9
Matthew M. Gubin, Washington University in St. Louis, USA
Using Genomics to Identify Antigenic Targets of Checkpoint Blockade Therapy

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: High-Throughput Approaches to Analyze and Target
Immune Cell Functions in Cancer (Joint)
Room: MacDonald ABC

Speaker 8 of 9
Niels van de Roemer, TRON-Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg, Germany
The Pharmacodynamics of Actively Personalized RNA-Based Anti-Tumor Vaccination

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: High-Throughput Approaches to Analyze and Target
Immune Cell Functions in Cancer (Joint)
Room: MacDonald ABC

Speaker 9 of 9
Serena Zilio, University of Miami, USA
4PD Functionalized PAMAM Dendrimer Allows the in vivo Rehabilitation of Tumor Educated Myeloid Cells

Monday, March 10 | 4:30PM - 5:00PM
Coffee Available
Room: MacDonald Foyer


Monday, March 10 | 5:00PM - 7:15PM
Location, Location, Location: Stromal Cell Effects
Room: MacDonald DEF

Speaker 1 of 6
* Alberto Mantovani, Humanitas University, Italy

Monday, March 10 | 5:00PM - 7:15PM
Location, Location, Location: Stromal Cell Effects
Room: MacDonald DEF

Speaker 2 of 6
Ronen Alon, Weizmann Institute of Science, Israel
How Do Tumors Educate the Vasculature to Recruit Tumor Helper Cells?

Monday, March 10 | 5:00PM - 7:15PM
Location, Location, Location: Stromal Cell Effects
Room: MacDonald DEF

Speaker 3 of 6
Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA
Leukocytes in Breast Tumor Progression

Monday, March 10 | 5:00PM - 7:15PM
Location, Location, Location: Stromal Cell Effects
Room: MacDonald DEF

Speaker 4 of 6
Sven Brandau, University Hospital Essen, Germany
Short Talk: Bi-Directional Interaction of Stromal Neutrophils and Tumor Cells Promotes Metastasis by Inducing an Invasive, NK-Resistant Tumor Cell Phenotype

Monday, March 10 | 5:00PM - 7:15PM
Location, Location, Location: Stromal Cell Effects
Room: MacDonald DEF

Speaker 5 of 6
Martina Seiffert, German Cancer Research Center, Germany
Short Talk: Chronic Lymphocytic Leukemia Patients Show Abnormalities within their Myeloid Cell Compartment

Monday, March 10 | 5:00PM - 7:15PM
Location, Location, Location: Stromal Cell Effects
Room: MacDonald DEF

Speaker 6 of 6
Shannon J. Turley, Genentech, Inc., USA
Influence of the Stromal Niche on Leukocyte Function in Solid Tumors

Monday, March 10 | 5:00PM - 7:15PM
Chronic Inflammation and Cancer
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 1 of 6
* Wendy S. Garrett, Harvard School of Public Health, USA


Monday, March 10 | 5:00PM - 7:15PM
Chronic Inflammation and Cancer
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 2 of 6
Timothy C. Wang, Columbia University, USA
GI Infection, Inflammation and Tumor Microenvironment


Monday, March 10 | 5:00PM - 7:15PM
Chronic Inflammation and Cancer
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 3 of 6
Fiona M. Powrie, University of Oxford, UK
Cellular and Molecular Pathways that Promote Inflammation-Driven Cancer


Monday, March 10 | 5:00PM - 7:15PM
Chronic Inflammation and Cancer
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 4 of 6
Nuray Gül, VU University Medical Center, Netherlands
Short Talk: Colon Resection-Induced Inflammation Stimulates Outgrowth of Liver Metastases from Circulating Tumor Cells


Monday, March 10 | 5:00PM - 7:15PM
Chronic Inflammation and Cancer
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 5 of 6
Curtis J. Henry, Emory University School of Medicine, USA
Short Talk: Inflamm-Aging Reduces B-Progenitor Function Leading to Increased Selection for Oncogenically-Initiated B-Cells


Monday, March 10 | 5:00PM - 7:15PM
Chronic Inflammation and Cancer
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 6 of 6
Robert F. Schwabe, Columbia University, USA
Liver Cancer: Microbiome and Myofibroblasts Fuel the Flames


Monday, March 10 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Frontenac Ballroom and Foyer


Monday, March 10 | 7:30PM - 10:00PM
Poster Session 1
Room: Frontenac Ballroom and Foyer


Tuesday, March 11 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac Ballroom and Foyer


Tuesday, March 11 | 8:00AM - 11:15AM
Co-Opting of Anti-Tumor Immunity by Myeloid-Derived Suppress
or Cells

Room: MacDonald DEF

Speaker 1 of 7
* Robert H. Vonderheide, University of Pennsylvania, USA

Tuesday, March 11 | 8:00AM - 11:15AM
Co-Opting of Anti-Tumor Immunity by Myeloid-Derived Suppress
or Cells

Room: MacDonald DEF

Speaker 2 of 7
Olivera J. Finn, University of Pittsburgh School of Medicine, USA
MDSC in Premalignant Disease

Tuesday, March 11 | 8:00AM - 11:15AM
Co-Opting of Anti-Tumor Immunity by Myeloid-Derived Suppress
or Cells

Room: MacDonald DEF

Speaker 3 of 7
Vincenzo Bronte, University of Verona, Italy
Tumor-Induced Immune Suppression by MDSC.

Tuesday, March 11 | 8:00AM - 11:15AM
Co-Opting of Anti-Tumor Immunity by Myeloid-Derived Suppress
or Cells

Room: MacDonald DEF

Speaker 4 of 7
Kebin Liu, Medical College of Georgia, USA
Short Talk: Deregulation of Apoptotic Factors Bcl-xL and Bax Confers Apoptotic Resistance to Myeloid-Derived Suppressive Cells and Contributes to Their Persistence in Cancers

Tuesday, March 11 | 8:00AM - 11:15AM
Co-Opting of Anti-Tumor Immunity by Myeloid-Derived Suppress
or Cells

Room: MacDonald DEF

Speaker 5 of 7
Viktor Umansky, German Cancer Research Center, Germany
Short Talk: Neutralizing Immunosuppressive Melanoma Microenvironment

Tuesday, March 11 | 8:00AM - 11:15AM
Co-Opting of Anti-Tumor Immunity by Myeloid-Derived Suppress
or Cells

Room: MacDonald DEF

Speaker 6 of 7
Suzanne Ostrand-Rosenberg, University of Maryland, USA
Inflammation and Alarmins as Drivers of Immune Suppressive Myeloid Cells and Tumor Progression

Tuesday, March 11 | 8:00AM - 11:15AM
Co-Opting of Anti-Tumor Immunity by Myeloid-Derived Suppress
or Cells

Room: MacDonald DEF

Speaker 7 of 7
Dmitry I. Gabrilovich, AstraZeneca, USA
The Fate of Myeloid-Derived Suppressor Cells is Regulated Through TRAIL Receptors Mediated Apoptosis

Tuesday, March 11 | 8:00AM - 11:15AM
Infection and Cancer Initiation
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 1 of 7
* Fiona M. Powrie, University of Oxford, UK


Tuesday, March 11 | 8:00AM - 11:15AM
Infection and Cancer Initiation
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 2 of 7
Martyn Plummer, International Agency for Research on Cancer, France
The Global Burden of Cancer Attributable to Infection


Tuesday, March 11 | 8:00AM - 11:15AM
Infection and Cancer Initiation
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 3 of 7
Cynthia L. Sears, Johns Hopkins University School of Medicine, USA
Colonic Commensals, B. fragilis and Colorectal Cancer (CRC)


Tuesday, March 11 | 8:00AM - 11:15AM
Infection and Cancer Initiation
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 4 of 7
Nicole Antonio, University of Bristol, UK
Short Talk: Live Imaging Studies of the Competing Inflammatory Responses to Tumors, Wounds and Infections in Adult and Larval Zebrafish


Tuesday, March 11 | 8:00AM - 11:15AM
Infection and Cancer Initiation
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 5 of 7
Johanna Classon, Karolinska Institutet, Sweden
Short Talk: Human Cytomegalovirus and Androgen Signaling in Prostate Cancer Progression


Tuesday, March 11 | 8:00AM - 11:15AM
Infection and Cancer Initiation
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 6 of 7
Xiao-Fan Wang, Duke University Medical Center, USA
Tumor Microenvironment: MicroRNAs and Metastasis


Tuesday, March 11 | 8:00AM - 11:15AM
Infection and Cancer Initiation
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 7 of 7
Elizabeth P. Murchison, University of Cambridge, UK
Clonally Transmissible Cancers in Dogs and Tasmanian Devils


Tuesday, March 11 | 9:20AM - 9:40AM
Coffee Break
Room: MacDonald Foyer


Tuesday, March 11 | 11:15AM - 1:00PM
Poster Setup
Room: Frontenac Ballroom and Foyer


Tuesday, March 11 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, March 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Frontenac Ballroom and Foyer


Tuesday, March 11 | 4:30PM - 5:00PM
Coffee Available
Room: MacDonald Foyer


Tuesday, March 11 | 5:00PM - 7:15PM
Re-Educating Tumor-Promoting Macrophages (Joint)
Room: MacDonald A-F

Speaker 1 of 6
* Lisa M. Coussens, Oregon Health & Science University, USA

Tuesday, March 11 | 5:00PM - 7:15PM
Re-Educating Tumor-Promoting Macrophages (Joint)
Room: MacDonald A-F

Speaker 2 of 6
Jo A. Van Ginderachter, VIB-Vrije Universiteit Brussel, Belgium
Macrophage plasticity in the tumor microenvironment

Tuesday, March 11 | 5:00PM - 7:15PM
Re-Educating Tumor-Promoting Macrophages (Joint)
Room: MacDonald A-F

Speaker 3 of 6
Johanna A. Joyce, University of Lausanne, Switzerland
Re-Educating Macrophages in the Tumor Microenvironment

Tuesday, March 11 | 5:00PM - 7:15PM
Re-Educating Tumor-Promoting Macrophages (Joint)
Room: MacDonald A-F

Speaker 4 of 6
Charlotte Rolny, Karolinska Institute, Sweden
Short Talk: SEMA3A Dictates a Pro-Inflammatory Program that Restricts Tumor Growth

Tuesday, March 11 | 5:00PM - 7:15PM
Re-Educating Tumor-Promoting Macrophages (Joint)
Room: MacDonald A-F

Speaker 5 of 6
David Liberg, Cantargia AB, Sweden
Short Talk: Inhibition of S100A9/Receptor Interactions by Novel Small Molecules Reduces Tumor Growth and Promotes CD8+ T Cell Infiltration

Tuesday, March 11 | 5:00PM - 7:15PM
Re-Educating Tumor-Promoting Macrophages (Joint)
Room: MacDonald A-F

Speaker 6 of 6
Alberto Mantovani, Humanitas University, Italy
Inflammation, Macrophage Polarization, and Cancer

Tuesday, March 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Frontenac Ballroom and Foyer


Tuesday, March 11 | 7:30PM - 10:00PM
Poster Session 2
Room: Frontenac Ballroom and Foyer


Wednesday, March 12 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac Ballroom and Foyer


Wednesday, March 12 | 8:00AM - 11:15AM
Evolving Immune Suppressive Mechanisms in the Tumor Microenv
ironment

Room: MacDonald DEF

Speaker 1 of 6
* Vincenzo Bronte, University of Verona, Italy

Wednesday, March 12 | 8:00AM - 11:15AM
Evolving Immune Suppressive Mechanisms in the Tumor Microenv
ironment

Room: MacDonald DEF

Speaker 2 of 6
Ruth Ganss, Harry Perkins Institute of Medical Research, Australia
Tumor-Targeted Therapy to Modulate Stroma

Wednesday, March 12 | 8:00AM - 11:15AM
Evolving Immune Suppressive Mechanisms in the Tumor Microenv
ironment

Room: MacDonald DEF

Speaker 3 of 6
Andrea Schietinger, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Initial Tumor-Antigen Encounters in Pre-/Early Malignant Lesions Lead to CD8 T Cell Dysfunction

Wednesday, March 12 | 8:00AM - 11:15AM
Evolving Immune Suppressive Mechanisms in the Tumor Microenv
ironment

Room: MacDonald DEF

Speaker 4 of 6
Jay A. Berzofsky, NCI, National Institutes of Health, USA
Short Talk: Blockade of TGF-beta to Overcome Negative Regulation in the Tumor Microenvironment: From Mice to Cancer Patients

Wednesday, March 12 | 8:00AM - 11:15AM
Evolving Immune Suppressive Mechanisms in the Tumor Microenv
ironment

Room: MacDonald DEF

Speaker 5 of 6
Andy Hurwitz, Agentus Therapeutics, USA
The Highs and Lows of T Cell Avidity: Tumor Immunity Meets Immune Suppression

Wednesday, March 12 | 8:00AM - 11:15AM
Evolving Immune Suppressive Mechanisms in the Tumor Microenv
ironment

Room: MacDonald DEF

Speaker 6 of 6
Bill C. Dougall, Amgen, USA
Distinct Roles of RANKL in Cancer: RANKL-Dependent Osteoclasts in the Tumor/Bone Microenvironment and Direct effects of RANKL on Breast Tumor Initiation and Progression

Wednesday, March 12 | 8:00AM - 11:00AM
The Impact of the Microbiome on Cancer
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 1 of 6
* Cynthia L. Sears, Johns Hopkins University School of Medicine, USA


Wednesday, March 12 | 8:00AM - 11:00AM
The Impact of the Microbiome on Cancer
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 2 of 6
Wendy S. Garrett, Harvard School of Public Health, USA
Fusobacteria and Colon Cancer


Wednesday, March 12 | 8:00AM - 11:00AM
The Impact of the Microbiome on Cancer
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 3 of 6
Eric G. Pamer, University of Chicago, USA
The Effects of Intestinal Tract Bacterial Diversity on Mortality Following Allogeneic Hematopoietic Stem Cell Transplantation


Wednesday, March 12 | 8:00AM - 11:00AM
The Impact of the Microbiome on Cancer
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 4 of 6
Yiping W. Han, Case Western Reserve University, USA
Short Talk: A Novel Mechanism by which Oral Commensal Fusobacterium nucleatum Promotes Colorectal Cancer


Wednesday, March 12 | 8:00AM - 11:00AM
The Impact of the Microbiome on Cancer
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 5 of 6
Lei Chen, Hong Kong Baptist University, China
Short Talk: The Impacts of Herbal Triterpenoid Saponins on Gut Microbiota and Cancer in ApcMin/+ Mice


Wednesday, March 12 | 8:00AM - 11:00AM
The Impact of the Microbiome on Cancer
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 6 of 6
Johanna W. Lampe, Fred Hutchinson Cancer Research Center, USA
Effects of Diet and Modulation of Inflammation on Cancer Risk


Wednesday, March 12 | 9:20AM - 9:40AM
Coffee Break
Room: MacDonald Foyer


Wednesday, March 12 | 11:15AM - 12:15PM
Meet the Editors Roundtable
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 1 of 4
* Teodoro Pulvirenti, Journal of Experimental Medicine, USA


Wednesday, March 12 | 11:15AM - 12:15PM
Meet the Editors Roundtable
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 2 of 4
Christine Borowski, Access Industries, USA


Wednesday, March 12 | 11:15AM - 12:15PM
Meet the Editors Roundtable
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 3 of 4
Zoltan Fehervari, Nature Publishing Group, UK


Wednesday, March 12 | 11:15AM - 12:15PM
Meet the Editors Roundtable
This session is from Cancer & Inflammation
Room: MacDonald ABC

Speaker 4 of 4
Nancy R. Gough, National Breast Cancer Coalition, USA


Wednesday, March 12 | 11:15AM - 1:00PM
Poster Setup
Room: Frontenac Ballroom and Foyer


Wednesday, March 12 | 11:15AM - 2:30PM
On Own for Lunch and Recreation


Wednesday, March 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Frontenac Ballroom and Foyer


Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: Insights into Immune Cell Function from Live Ima
ging (Joint)
Room: MacDonald ABC

Speaker 1 of 9
* Mikael J. Pittet, Massachusetts General Hospital, USA

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: Insights into Immune Cell Function from Live Ima
ging (Joint)
Room: MacDonald ABC

Speaker 2 of 9
* Ronen Alon, Weizmann Institute of Science, Israel

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: Insights into Immune Cell Function from Live Ima
ging (Joint)
Room: MacDonald ABC

Speaker 3 of 9
Miranda L. Broz, Bristol Myers Squibb, USA
Distinct Lineages of Tolerogenic and Activating Myeloid Cells from Tumors

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: Insights into Immune Cell Function from Live Ima
ging (Joint)
Room: MacDonald ABC

Speaker 4 of 9
Esther N. Arwert, Francis Crick Institute, UK
Identification of Molecular and Functional Differences in Tumour Associated Macrophage Subsets

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: Insights into Immune Cell Function from Live Ima
ging (Joint)
Room: MacDonald ABC

Speaker 5 of 9
Liane Babes, University of Calgary, Canada
Visualizing Tumor Cell Killing by Immune Cells in the Liver

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: Insights into Immune Cell Function from Live Ima
ging (Joint)
Room: MacDonald ABC

Speaker 6 of 9
Guy Shakhar, Weizmann Institute of Science, Israel
Intravital Imaging of Melanoma Reveals that Target Cytolysis by CTLs Is Strictly Contact and Antigen-Dependent

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: Insights into Immune Cell Function from Live Ima
ging (Joint)
Room: MacDonald ABC

Speaker 7 of 9
Tali Feferman, Weizmann Institute of Science, Israel
Angiogenesis Promotes Intratumoral CTL Dissemination and Cytotoxicity

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: Insights into Immune Cell Function from Live Ima
ging (Joint)
Room: MacDonald ABC

Speaker 8 of 9
David Askew, Case Western Reserve University, USA
Heterogeneity of T Cell Acute Lymphoblastic Leukemia Cells Derived from Constitutive Expression of Intracellular Notch 1

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: Insights into Immune Cell Function from Live Ima
ging (Joint)
Room: MacDonald ABC

Speaker 9 of 9
Derek William Laux, Queen's Medical Research Institute, University of Edinburgh, UK
A Trophic Role for Innate Immunity in Cancer Progression

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 3: Immune Suppressive Myeloid Cells (Joint)
Room: MacDonald DEF

Speaker 1 of 10
* Lisa H. Butterfield, University of Pittsburgh, USA

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 3: Immune Suppressive Myeloid Cells (Joint)
Room: MacDonald DEF

Speaker 2 of 10
* Rolf Kiessling, Karolinska Institute, Sweden

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 3: Immune Suppressive Myeloid Cells (Joint)
Room: MacDonald DEF

Speaker 3 of 10
Yago Pico de Coaña, Karolinska Institutet, Sweden
Effects of Ipilimumab on Myeloid Derived Suppressor Cells in Advanced Melanoma Patients

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 3: Immune Suppressive Myeloid Cells (Joint)
Room: MacDonald DEF

Speaker 4 of 10
Erik Thiele Orberg, University Clinic Rechts der Isar, Technical University Munich, Germany
Immature Myeloid Cells as a Link between Inflammation and Tumorigenesis in Bacterial Colitis-Associated Carcinogenesis

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 3: Immune Suppressive Myeloid Cells (Joint)
Room: MacDonald DEF

Speaker 5 of 10
Xianming Huang, University of Texas Southwestern Medical Center Dallas, USA
Phosphatidylserine-Targeting Antibodies Induce M1 Macrophage Polarization, Promote Myeloid Derived Suppressor Cell Differentiation and Boost Tumor-Specific Immunity

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 3: Immune Suppressive Myeloid Cells (Joint)
Room: MacDonald DEF

Speaker 6 of 10
Nelly Vey, Cancer Research Centre of Lyon, France
The Antimicrobial Peptide LL37 Activates Plasmacytoid Dendritic Cells in Breast Cancer

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 3: Immune Suppressive Myeloid Cells (Joint)
Room: MacDonald DEF

Speaker 7 of 10
Rinat Zaynagetdinov, EMD Serono, USA
Alveolar Macrophages Promote Lung Tumorigenesis in the Context of Chronic Airway Inflammation through Differentiation of Regulatory T Cells (Tregs)

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 3: Immune Suppressive Myeloid Cells (Joint)
Room: MacDonald DEF

Speaker 8 of 10
Seth B. Coffelt, University of Glasgow and Cancer Research UK, UK
Gamma delta T Cells and Neutrophils Conspire together to Promote Breast Cancer Metastasis

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 3: Immune Suppressive Myeloid Cells (Joint)
Room: MacDonald DEF

Speaker 9 of 10
Kellie A. Charles, University of Sydney, Australia
Monocytic Myeloid Derived Suppressor Cells (Mo-MDSC) Decrease with 5FU-based Chemotherapy in Colorectal Cancer Patients

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 3: Immune Suppressive Myeloid Cells (Joint)
Room: MacDonald DEF

Speaker 10 of 10
Ofer Levy, Compugen Ltd., Israel
Identification of Novel Immune Checkpoints as Potential Targets for Cancer Immunotherapy

Wednesday, March 12 | 4:30PM - 5:00PM
Coffee Available
Room: MacDonald Foyer


Wednesday, March 12 | 5:00PM - 7:00PM
Antigen Presentation in the Tumor Microenvironment
Room: MacDonald DEF

Speaker 1 of 5
* Olivera J. Finn, University of Pittsburgh School of Medicine, USA

Wednesday, March 12 | 5:00PM - 7:00PM
Antigen Presentation in the Tumor Microenvironment
Room: MacDonald DEF

Speaker 2 of 5
Jose Conejo-Garcia, Wistar Institute, USA
Dynamic Expression of the Genomic Organizer SATB1 Regulates Dendritic Cell Differentiation and Immunostimulatory Functions in Cancer

Wednesday, March 12 | 5:00PM - 7:00PM
Antigen Presentation in the Tumor Microenvironment
Room: MacDonald DEF

Speaker 3 of 5
Lisa H. Butterfield, University of Pittsburgh, USA
Short Talk: Tumor-Derived alpha-Fetoprotein Impairs the Differentiation and T Cell Stimulatory Activity of Human Dendritic Cells

Wednesday, March 12 | 5:00PM - 7:00PM
Antigen Presentation in the Tumor Microenvironment
Room: MacDonald DEF

Speaker 4 of 5
Brad H. Nelson, BC Cancer Agency, Canada
Short Talk: Surveillance of the Tumor Mutanome by T Cells during Progression from Primary to Recurrent Ovarian Cancer

Wednesday, March 12 | 5:00PM - 7:00PM
Antigen Presentation in the Tumor Microenvironment
Room: MacDonald DEF

Speaker 5 of 5
Eduardo M. Sotomayor, Moffitt Cancer Center and Research Institute, USA
Epigenetic Manipulation of Antigen-Presenting Cells to Influence Immune Activation versus Immune Tolerance

Wednesday, March 12 | 5:00PM - 7:15PM
Origins and Therapeutic Targeting of Myeloid Cells in Physio
logy and Cancer
This session is from Cancer & Inflammation

Room: MacDonald ABC

Speaker 1 of 6
* Eric G. Pamer, University of Chicago, USA


Wednesday, March 12 | 5:00PM - 7:15PM
Origins and Therapeutic Targeting of Myeloid Cells in Physio
logy and Cancer
This session is from Cancer & Inflammation

Room: MacDonald ABC

Speaker 2 of 6
Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
In vivo Characterisation of the YS Progenitor for Tissue Resident Macrophages


Wednesday, March 12 | 5:00PM - 7:15PM
Origins and Therapeutic Targeting of Myeloid Cells in Physio
logy and Cancer
This session is from Cancer & Inflammation

Room: MacDonald ABC

Speaker 3 of 6
Mikael J. Pittet, Massachusetts General Hospital, USA
Origins of Tumor-Associated Myeloid Cells


Wednesday, March 12 | 5:00PM - 7:15PM
Origins and Therapeutic Targeting of Myeloid Cells in Physio
logy and Cancer
This session is from Cancer & Inflammation

Room: MacDonald ABC

Speaker 4 of 6
Alessia Zoso, University of Miami, USA
Short Talk: Molecular and Functional Characterization of IDO-Expressing Human Fibrocytic Myeloid Derived Suppressor Cells


Wednesday, March 12 | 5:00PM - 7:15PM
Origins and Therapeutic Targeting of Myeloid Cells in Physio
logy and Cancer
This session is from Cancer & Inflammation

Room: MacDonald ABC

Speaker 5 of 6
Mary Christine Hollander, NCI/National Institutes of Health, USA
Short Talk: Myeloid Specific TGF-beta Signaling and Cancer Metastasis


Wednesday, March 12 | 5:00PM - 7:15PM
Origins and Therapeutic Targeting of Myeloid Cells in Physio
logy and Cancer
This session is from Cancer & Inflammation

Room: MacDonald ABC

Speaker 6 of 6
Miriam Merad, Mount Sinai School of Medicine, USA
Tracing the Cell of Origin for Resident Macrophage Populations


Wednesday, March 12 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Frontenac Ballroom and Foyer


Wednesday, March 12 | 7:30PM - 10:00PM
Poster Session 3
Room: Frontenac Ballroom and Foyer


Thursday, March 13 | 7:00AM - 8:00AM
Breakfast
Room: Frontenac Ballroom and Foyer


Thursday, March 13 | 8:00AM - 11:00AM
Overcoming Immune Suppression in the Tumor Microenvironment
Room: MacDonald DEF

Speaker 1 of 7
* Dmitry I. Gabrilovich, AstraZeneca, USA

Thursday, March 13 | 8:00AM - 11:00AM
Overcoming Immune Suppression in the Tumor Microenvironment
Room: MacDonald DEF

Speaker 2 of 7
Martin Oft, ARMO BioSciences, USA
All TILs, no TAMs - or how PEG-IL-10 Activates Intratumoral CD8 T Cell Cytotoxicity

Thursday, March 13 | 8:00AM - 11:00AM
Overcoming Immune Suppression in the Tumor Microenvironment
Room: MacDonald DEF

Speaker 3 of 7
George Coukos, University Hospital of Lausanne - CHUV, Switzerland
Immune Escape and Angiogenesis

Thursday, March 13 | 8:00AM - 11:00AM
Overcoming Immune Suppression in the Tumor Microenvironment
Room: MacDonald DEF

Speaker 4 of 7
Brian Ruffell, Oregon Health & Science University, USA
Short Talk: TH2 Cytokines Limit Chemotherapeutic Efficacy by Repressing Dendritic Cell Production of IL12

Thursday, March 13 | 8:00AM - 11:00AM
Overcoming Immune Suppression in the Tumor Microenvironment
Room: MacDonald DEF

Speaker 5 of 7
Sadna Budhu, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Blockade of Treg Derived TGF-beta Abrogates Suppression of Effector T Cell Function within the Tumor Microenvironment

Thursday, March 13 | 8:00AM - 11:00AM
Overcoming Immune Suppression in the Tumor Microenvironment
Room: MacDonald DEF

Speaker 6 of 7
Alan Serrels, University of Edinburgh, UK
Short Talk: Evading the Anti-Tumor Immune Response - A Novel Role for Focal Adhesion Kinase

Thursday, March 13 | 8:00AM - 11:00AM
Overcoming Immune Suppression in the Tumor Microenvironment
Room: MacDonald DEF

Speaker 7 of 7
Thomas Blankenstein, Max Delbruck Center for Molecular Medicine, Germany
Spontaneous and Therapy-Induced T Cell Responses to Cancer

Thursday, March 13 | 8:00AM - 11:15AM
Inflammation as a Target and Modulator of Cancer Therapeutic
s
This session is from Cancer & Inflammation

Room: MacDonald ABC

Speaker 1 of 7
* Giorgio Trinchieri, NCI, National Institutes of Health, USA


Thursday, March 13 | 8:00AM - 11:15AM
Inflammation as a Target and Modulator of Cancer Therapeutic
s
This session is from Cancer & Inflammation

Room: MacDonald ABC

Speaker 2 of 7
Michael Karin, University of California, San Diego, USA
Liver Inflammation, Obesity and Cancer


Thursday, March 13 | 8:00AM - 11:15AM
Inflammation as a Target and Modulator of Cancer Therapeutic
s
This session is from Cancer & Inflammation

Room: MacDonald ABC

Speaker 3 of 7
Napoleone Ferrara, University of California, San Diego, USA
Myeloid Cells and VEGF?Independent Tumor Angiogenesis


Thursday, March 13 | 8:00AM - 11:15AM
Inflammation as a Target and Modulator of Cancer Therapeutic
s
This session is from Cancer & Inflammation

Room: MacDonald ABC

Speaker 4 of 7
Mauricio da Silva Caetano, University of Texas MD Anderson Cancer Center, USA
Short Talk: Pharmacologic Targeting of IL-6 Suppresses Tumor Progression in a K-ras Mutant Lung Cancer Mouse Model through Re-Educating the Tumor Microenvironment


Thursday, March 13 | 8:00AM - 11:15AM
Inflammation as a Target and Modulator of Cancer Therapeutic
s
This session is from Cancer & Inflammation

Room: MacDonald ABC

Speaker 5 of 7
Maryse Dagenais, McGill University, Canada
Short Talk: The Role of the Cellular Inhibitor of Apoptosis Protein cIAP2 in Colitis and Colitis-Associated Colorectal Cancer


Thursday, March 13 | 8:00AM - 11:15AM
Inflammation as a Target and Modulator of Cancer Therapeutic
s
This session is from Cancer & Inflammation

Room: MacDonald ABC

Speaker 6 of 7
Carola H. Ries, Roche Innovation Center Munich, Germany
Targeting Tumor-Associated Macrophages in Cancer Patients


Thursday, March 13 | 8:00AM - 11:15AM
Inflammation as a Target and Modulator of Cancer Therapeutic
s
This session is from Cancer & Inflammation

Room: MacDonald ABC

Speaker 7 of 7
Martin Brown, Stanford University, USA
Myeloid Cells Govern the Response of Tumors to Irradiation


Thursday, March 13 | 9:20AM - 9:40AM
Coffee Break
Room: MacDonald Foyer


Thursday, March 13 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Thursday, March 13 | 4:30PM - 5:00PM
Coffee Available
Room: MacDonald Foyer


Thursday, March 13 | 5:00PM - 7:15PM
Therapeutic Manipulation of the Tumor Microenvironment (Join
t)

Room: MacDonald A-F

Speaker 1 of 6
* Johanna A. Joyce, University of Lausanne, Switzerland

Thursday, March 13 | 5:00PM - 7:15PM
Therapeutic Manipulation of the Tumor Microenvironment (Join
t)

Room: MacDonald A-F

Speaker 2 of 6
* Suzanne Ostrand-Rosenberg, University of Maryland, USA

Thursday, March 13 | 5:00PM - 7:15PM
Therapeutic Manipulation of the Tumor Microenvironment (Join
t)

Room: MacDonald A-F

Speaker 3 of 6
Robert H. Vonderheide, University of Pennsylvania, USA
Inflammatory Networks and Immune Privilege in Carcinoma

Thursday, March 13 | 5:00PM - 7:15PM
Therapeutic Manipulation of the Tumor Microenvironment (Join
t)

Room: MacDonald A-F

Speaker 4 of 6
Giorgio Trinchieri, NCI, National Institutes of Health, USA
The Role of Inflammation in Carcinogenesis and Response to Cancer Therapy

Thursday, March 13 | 5:00PM - 7:15PM
Therapeutic Manipulation of the Tumor Microenvironment (Join
t)

Room: MacDonald A-F

Speaker 5 of 6
Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK
Targeting Inflammatory Cytokines and Chemokines

Thursday, March 13 | 5:00PM - 7:15PM
Therapeutic Manipulation of the Tumor Microenvironment (Join
t)

Room: MacDonald A-F

Speaker 6 of 6
Carl H. June, University of Pennsylvania, USA
Adoptive Therapy with Engineered T Cells

Thursday, March 13 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Frontenac Ballroom and Foyer


Thursday, March 13 | 8:00PM - 11:00PM
Entertainment
Room: Frontenac Ballroom and Foyer


Thursday, March 13 | 8:00PM - 11:00PM
Cash Bar
Room: Frontenac Ballroom and Foyer


Friday, March 14 | 10:25AM - 10:25AM
Departure


*Session Chair.