Web Desc
HIV Vaccines: Adaptive Immunity and Beyond
joint with HIV Pathogenesis - Virus vs. Host
Organizer(s): Nicole Frahm, Susan W. Barnett and Galit Alter
Date: March 09 - 14, 2014
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by Sangamo BioSciences, Inc. Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
The HIV vaccine field has undergone dramatic changes over the last several years: from the failure of the promising MRKAd5-HIV-1 vaccine to provide any protection from acquisition or disease progression to the first demonstration that an HIV vaccine can actually show efficacy with a regimen that was predicted to fail in RV144. Following these developments, the field has turned from T-cell based vaccines favored for the late nineties/early 2000s back to antibody-inducing strategies, although with a reduced focus on broadly neutralizing antibodies since these were not detected in RV144 vaccinees. This meeting aims at bringing the cellular and humoral factions together to work on a holistic approach to HIV vaccination: induction of antibodies – both binding and neutralizing – to prevent infection; a safety net of CD8 T-cell responses to control viral replication in those hosts that do become infected; and CD4 T cell help for both effector arms. In addition, we seek to provide a better understanding of the interplay of innate immune responses and the resulting adaptive response, as well as a closer look at the signals that are crucial for the induction of long-lasting memory responses. This comprehensive approach to vaccinology will be complemented by a thorough portrayal of HIV transmission, both from the viral perspective as well as the portal of entry; and by a closer look of how vaccines interact with the host’s genetic profile. Taken together, this meeting will bring scientists from all denominations together to tackle the design of a new generation of highly effective HIV vaccines.
Global Health Travel Award Deadline: October 8 2013
Scholarship Deadline: November 7 2013
Discounted Abstract Deadline: November 7 2013
Abstract Deadline: December 11 2013
Discounted Registration Deadline: January 10 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates FoundationSangamo BioSciences, Inc.
We gratefully acknowledge additional support for this conference from:
BioLegend, Inc.Canadian HIV Vaccine Initiative Research & Development Alliance
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Vaccines and Diagnostics
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI110241-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 09 | 4:00PM - 8:00PM
Arrival and Registration
Room: Van Horne Foyer


Sunday, March 09 | 4:30PM - 6:00PM
Keystone Symposia Webcast - HIV/AIDS: Strategies for an Endg
ame

Room: Shaughnessy
Taped rebroadcast of the first virtual Keystone Symposia event. This can also be viewed online at any time at www.visualwebcaster.com/KSHIV.

Monday, March 10 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Monday, March 10 | 8:00AM - 9:00AM
Opening Addresses (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 4
* Nicole Frahm, Bill & Melinda Gates Medical Research Institute, USA

Monday, March 10 | 8:00AM - 9:00AM
Opening Addresses (Joint)
Room: Van Horne Ballroom A/B

Speaker 2 of 4
* J. Victor Garcia-Martinez, University of North Carolina at Chapel Hill, USA

Monday, March 10 | 8:00AM - 9:00AM
Opening Addresses (Joint)
Room: Van Horne Ballroom A/B

Speaker 3 of 4
Myron S. Cohen, University of North Carolina at Chapel Hill, USA
Integrated HIV Prevention Strategies: High Time for a Synergistic Approach

Monday, March 10 | 8:00AM - 9:00AM
Opening Addresses (Joint)
Room: Van Horne Ballroom A/B

Speaker 4 of 4
Carl W. Dieffenbach, NIAID, National Institutes of Health, USA
The Big Questions: The Basic Research Progress Needed to Help Control the HIV/AIDS Pandemic

Monday, March 10 | 9:00AM - 11:30AM
Portals of Entry and Sites of Dissemination (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 7
* James A. Hoxie, University of Pennsylvania, USA

Monday, March 10 | 9:00AM - 11:30AM
Portals of Entry and Sites of Dissemination (Joint)
Room: Van Horne Ballroom A/B

Speaker 2 of 7
* Thomas Musich, Armed Forces Research Institute of Medical Sciences, Thailand

Monday, March 10 | 9:00AM - 11:30AM
Portals of Entry and Sites of Dissemination (Joint)
Room: Van Horne Ballroom A/B

Speaker 3 of 7
J. Victor Garcia-Martinez, University of North Carolina at Chapel Hill, USA
Mechanistic Analysis of Vaginal HIV Transmission and Prevention

Monday, March 10 | 9:00AM - 11:30AM
Portals of Entry and Sites of Dissemination (Joint)
Room: Van Horne Ballroom A/B

Speaker 4 of 7
Peter A. Anton, David Geffen School of Medicine at UCLA, USA
Rectal HIV Transmission

Monday, March 10 | 9:00AM - 11:30AM
Portals of Entry and Sites of Dissemination (Joint)
Room: Van Horne Ballroom A/B

Speaker 5 of 7
Ashley T. Haase, University of Minnesota, USA
Virus-Host Immune Interactions at the Portal of Entry and Vaccine Design to Prevent HIV-1 Transmission to Women

Monday, March 10 | 9:00AM - 11:30AM
Portals of Entry and Sites of Dissemination (Joint)
Room: Van Horne Ballroom A/B

Speaker 6 of 7
Thomas J. Hope, Northwestern University, USA
Short Talk: Hotspots of SIV Infection in the Female Reproductive Tract after Vaginal Exposure of Rhesus macaques to Single Round Dual Reporter Vector

Monday, March 10 | 9:00AM - 11:30AM
Portals of Entry and Sites of Dissemination (Joint)
Room: Van Horne Ballroom A/B

Speaker 7 of 7
Samuel K. Lai, University of North Carolina at Chapel Hill, USA
Short Talk: Influence of Vaginal Microbiota on the Diffusional Barrier Properties of Cervicovaginal Mucus against HIV

Monday, March 10 | 9:40AM - 10:00AM
Coffee Break
Room: Van Horne Foyer


Monday, March 10 | 11:30AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Monday, March 10 | 11:30AM - 2:30PM
On Own for Lunch and Recreation


Monday, March 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Mucosal Immunity
Room: Van Horne Ballroom A/B

Speaker 1 of 10
* Marjorie Robert-Guroff, NCI, National Institutes of Health, USA

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Mucosal Immunity
Room: Van Horne Ballroom A/B

Speaker 2 of 10
* Thomas J. Hope, Northwestern University, USA

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Mucosal Immunity
Room: Van Horne Ballroom A/B

Speaker 3 of 10
Liang Shang, University of Minnesota, USA
Immune Complex – Fc Receptor Interactions Reduce Inflammatory Responses at the Genital Mucosa as a Correlate of SIV Vaccine-Induced Protection

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Mucosal Immunity
Room: Van Horne Ballroom A/B

Speaker 4 of 10
Yichuan Wang, NCI, National institutes of Health, USA
Vaginal Type-II Mucosa Acts as an Inductive Site for the Generation of Primary CD8+ T Cell Mucosal Immune Responses

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Mucosal Immunity
Room: Van Horne Ballroom A/B

Speaker 5 of 10
Genoveffa Franchini, NCI, National Institutes of Health, USA
Modulation of the RAS Pathways as a Biomarker of Protection Against HIV and as a Means to Improve Vaccine Efficacy

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Mucosal Immunity
Room: Van Horne Ballroom A/B

Speaker 6 of 10
Rena D. Astronomo, Fred Hutchinson Cancer Research Center, USA
Neutrophils May Provide Front-Line Antibody Effector Functions in the Cervical But Not the Vaginal Mucosa

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Mucosal Immunity
Room: Van Horne Ballroom A/B

Speaker 7 of 10
Béhazine Combadiere, Centre d'Immunologie et des Maladies Infectieuses, France
Cutaneous Routes for HIV Vaccination Strategies

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Mucosal Immunity
Room: Van Horne Ballroom A/B

Speaker 8 of 10
Sampa Santra, Harvard Medical School, USA
Simian-Human Immunodeficiency Viruses with Transmitted/Founder Clade C HIV-1 Envelopes

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Mucosal Immunity
Room: Van Horne Ballroom A/B

Speaker 9 of 10
Thorsten Demberg, NCI, National Institutes of Health, USA
Phenotyping and Characterization of Mucosal Memory B-Cell Populations in the SIV/SHIV Rhesus macaque Model

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Mucosal Immunity
Room: Van Horne Ballroom A/B

Speaker 10 of 10
Thomas Musich, Armed Forces Research Institute of Medical Sciences, Thailand
Purification and Functional Characterization of Mucosal IgA from Vaccinated and SIV-Infected Rhesus macaques

Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Role of Animal Models for HIV Research
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 1 of 10
* Roberto F. Speck, University of Zurich, Switzerland


Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Role of Animal Models for HIV Research
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 2 of 10
* Frank Kirchhoff, University of Ulm, Germany


Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Role of Animal Models for HIV Research
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 3 of 10
Atef F. Allam, Walter Reed Institute of Research, USA
Characterization of B- and T Cells in the Gut Mucosa of Humanized DRAG Mice
During HIV Infection


Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Role of Animal Models for HIV Research
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 4 of 10
Timothy E. Dudek, Ragon Institute of MGH, MIT and Harvard, USA
Immunization of Humanized BLT Mice Against HIV Influences Early Immune Responses and Viral Loads


Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Role of Animal Models for HIV Research
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 5 of 10
Yanhui Cai, Tulane National Primate Research Center, USA
SIV Infection of Lung Interstitial Macrophages Contributes to Tissue Damage and Inflammatory Responses in the Lung


Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Role of Animal Models for HIV Research
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 6 of 10
Christopher A. Gaulke, University of California, Davis, USA
SIV Induced Disruption of microRNA Expression in the Small Intestine Contributes to Epithelial Barrier Dysfunction


Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Role of Animal Models for HIV Research
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 7 of 10
Jung Joo Hong, Korea Research Institute of Bioscience and Biotechnology, South Korea
Early Lymphoid Responses and Germinal Center Formation Correlates with Lower Viral Load Set Points and Better Prognosis of SIV Infection


Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Role of Animal Models for HIV Research
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 8 of 10
Luca Micci, Emory University, YNPRC, USA
Interleukin-21 Reduces Residual Immune Activation in ART-Suppressed SIV-Infected Rhesus macaques by Restoring Intestinal Th17 and Th22 Cells


Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Role of Animal Models for HIV Research
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 9 of 10
M. Christine Zink, Johns Hopkins University, USA
Sustained Upregulation of Neurotoxic Kynurenine Pathway Metabolites in cART-Treated SIV-Infected Pigtailed Macaques: Impact on Neuroinflammation and Serotonin Metabolism


Monday, March 10 | 2:30PM - 4:30PM
Workshop 1: Role of Animal Models for HIV Research
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 10 of 10
Adrienne E. Swanstrom, University of Pennsylvania, USA
In Vivo Evaluation of a Novel Variant of SIVmac Lacking CD4 Tropism


Monday, March 10 | 3:30PM - 5:00PM
Keystone Symposia Webcast - HIV/AIDS: Strategies for an Endg
ame

Room: Shaughnessy
Taped rebroadcast of the first virtual Keystone Symposia event. This can also be viewed online at any time at www.visualwebcaster.com/KSHIV.

Monday, March 10 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Monday, March 10 | 5:00PM - 7:15PM
Programming Durable Immunity
Room: Van Horne Ballroom A/B

Speaker 1 of 7
* Rafael Cubas, Genentech, USA

Monday, March 10 | 5:00PM - 7:15PM
Programming Durable Immunity
Room: Van Horne Ballroom A/B

Speaker 2 of 7
* Hendrik Streeck, Military HIV Research Program, USA

Monday, March 10 | 5:00PM - 7:15PM
Programming Durable Immunity
Room: Van Horne Ballroom A/B

Speaker 3 of 7
Robert A. Seder, NIAID, National Institutes of Health, USA
Development of a Malaria Vaccine: A Parable of Vaccine Delivery, Breadth of Antigens and Effector Cells

Monday, March 10 | 5:00PM - 7:15PM
Programming Durable Immunity
Room: Van Horne Ballroom A/B

Speaker 4 of 7
Mark K. Slifka, Oregon National Primate Research Center, Oregon Health & Science University, USA
Potential Mechanisms for Sustaining Long-Term Humoral Immunity

Monday, March 10 | 5:00PM - 7:15PM
Programming Durable Immunity
Room: Van Horne Ballroom A/B

Speaker 5 of 7
Shane Crotty, La Jolla Institute for Immunology, USA
Tfh Cells and Memory Tfh Cells

Monday, March 10 | 5:00PM - 7:15PM
Programming Durable Immunity
Room: Van Horne Ballroom A/B

Speaker 6 of 7
Diego J. Farfán-Arribas, University of Massachusetts Medical School, USA
Short Talk: Evidence on the Involvement of Germinal Centers and T Follicular Helper Cells in DNA Immunization for HIV Vaccine Development

Monday, March 10 | 5:00PM - 7:15PM
Programming Durable Immunity
Room: Van Horne Ballroom A/B

Speaker 7 of 7
Ann J. Hessell, Oregon Health & Science University, USA
Short Talk: Cross-Clade Neutralizing Antibodies and Envelope-Specific TFH Cell Responses Are Elicited in Macaques Co-Immunized with DNA and Protein Env Vaccines Derived from Multiple Subjects during Development of Breadth

Monday, March 10 | 5:00PM - 7:15PM
Host-Viral Co-Evolution
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 1 of 8
* Quentin J. Sattentau, Sir William Dunn School of Pathology, UK


Monday, March 10 | 5:00PM - 7:15PM
Host-Viral Co-Evolution
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 2 of 8
* Doris Wilflingseder, Insbruck Medical University, Austria


Monday, March 10 | 5:00PM - 7:15PM
Host-Viral Co-Evolution
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 3 of 8
Welkin E. Johnson, Boston College, USA
Genetic Barriers to Cross-Species Transmission and Emergence of Primate Immunodeficiency Viruses


Monday, March 10 | 5:00PM - 7:15PM
Host-Viral Co-Evolution
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 4 of 8
Robert J. Gifford, University of Glasgow, UK
The Evolution and Emergence of Lentiviral Pandemics since the Neolithic Era


Monday, March 10 | 5:00PM - 7:15PM
Host-Viral Co-Evolution
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 5 of 8
Viviana Simon, Icahn School of Medicine at Mount Sinai, USA
Short Talk: HIV Evolution in Humanized Mice


Monday, March 10 | 5:00PM - 7:15PM
Host-Viral Co-Evolution
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 6 of 8
Li Wu, Ohio State University, USA
Short Talk: Identification of Cellular Proteins Interacting with the Retroviral Restriction Factor SAMHD1


Monday, March 10 | 5:00PM - 7:15PM
Host-Viral Co-Evolution
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 7 of 8
Thijs Booiman, University of Amsterdam, Netherlands
Short Talk: The Effect of Genetic Variation in Trex1 on HIV-1 Disease Progression and in vitro HIV-1 Replication


Monday, March 10 | 5:00PM - 7:15PM
Host-Viral Co-Evolution
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 8 of 8
Angelique Hoelzemer, Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: Selection of a Distinct HIV-1 p24 Gag Sequence Polymorphism in KIR2DL3/HLA-C*03:04+ Individuals Is Associated with Viral Escape from Recognition by KIR2DL3+ NK Cells


Monday, March 10 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Mezzanine 2


Monday, March 10 | 7:30PM - 10:00PM
Poster Session 1
Room: Mezzanine 2


Tuesday, March 11 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Tuesday, March 11 | 7:30AM - 8:00AM
Poster Setup
Room: Mezzanine 2


Tuesday, March 11 | 8:00AM - 7:00PM
Poster Viewing
Room: Mezzanine 2


Tuesday, March 11 | 8:00AM - 11:00AM
Inducing Protective Immunity
Room: Van Horne Ballroom A/B

Speaker 1 of 8
* Anne-Sophie M. Dugast, Ragon Institute of MGH, MIT and Harvard, USA

Tuesday, March 11 | 8:00AM - 11:00AM
Inducing Protective Immunity
Room: Van Horne Ballroom A/B

Speaker 2 of 8
* Adrian B. McDermott, National Institutes of Health, USA

Tuesday, March 11 | 8:00AM - 11:00AM
Inducing Protective Immunity
Room: Van Horne Ballroom A/B

Speaker 3 of 8
William H. Robinson, Stanford University School of Medicine, USA
Protective B Cell Responses

Tuesday, March 11 | 8:00AM - 11:00AM
Inducing Protective Immunity
Room: Van Horne Ballroom A/B

Speaker 4 of 8
Gabriel D. Victora, Rockefeller University, USA
Cellular Dynamics and Clonal Selection in the Germinal Center

Tuesday, March 11 | 8:00AM - 11:00AM
Inducing Protective Immunity
Room: Van Horne Ballroom A/B

Speaker 5 of 8
Jonathan W. Yewdell, NIAID, National Institutes of Health, USA
Translating Information for MHC Class Immunosurveillance

Tuesday, March 11 | 8:00AM - 11:00AM
Inducing Protective Immunity
Room: Van Horne Ballroom A/B

Speaker 6 of 8
Susan W. Barnett, Bill & Melinda Gates Foundation, USA
Non-Viral Delivery of Self-Amplifying mRNA: A Versatile Synthetic Vaccine Platform for HIV

Tuesday, March 11 | 8:00AM - 11:00AM
Inducing Protective Immunity
Room: Van Horne Ballroom A/B

Speaker 7 of 8
Kelly D. Moynihan, Third Rock Ventures, USA
Short Talk: Lymph-Node Targeting of Molecular Vaccines through “Albumin Hitchhiking”

Tuesday, March 11 | 8:00AM - 11:00AM
Inducing Protective Immunity
Room: Van Horne Ballroom A/B

Speaker 8 of 8
Joseph G. Jardine, The Scripps Research Institute, USA
Short Talk: Design of Germline-Targeted Immunogens with Enhanced Breadth for VRC01-Class Precursors

Tuesday, March 11 | 8:00AM - 11:15AM
Viral Entry/Exit and Host Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 1 of 8
* Eric Hunter, Emory University, USA


Tuesday, March 11 | 8:00AM - 11:15AM
Viral Entry/Exit and Host Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 2 of 8
* Gilda Tachedjian, Burnet Institute, Australia


Tuesday, March 11 | 8:00AM - 11:15AM
Viral Entry/Exit and Host Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 3 of 8
Wesley I. Sundquist, University of Utah School of Medicine, USA
HIV Assembly and Egress


Tuesday, March 11 | 8:00AM - 11:15AM
Viral Entry/Exit and Host Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 4 of 8
Vineet N. KewalRamani, NCI, National Institutes of Health, USA
HIV Entry and Nuclear Translocation


Tuesday, March 11 | 8:00AM - 11:15AM
Viral Entry/Exit and Host Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 5 of 8
Fadila Bouamr, NIAID, National Institutes of Health, USA
The Host and HIV Exit


Tuesday, March 11 | 8:00AM - 11:15AM
Viral Entry/Exit and Host Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 6 of 8
Janice E. Clements, Johns Hopkins University, USA
Macrophages Contribute to the Latent Viral Reservoir in Tissues of cART Suppressed SIV-Infected Macaques


Tuesday, March 11 | 8:00AM - 11:15AM
Viral Entry/Exit and Host Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 7 of 8
Peijun Zhang, University of Oxford, UK
Short Talk: Structural Mechanisms of HIV-1 Capsid Assembly and Maturation


Tuesday, March 11 | 8:00AM - 11:15AM
Viral Entry/Exit and Host Genetics
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 8 of 8
Amy Hulme, Northwestern University, USA
Short Talk: Viral and Cellular Factors Affect HIV-1 Uncoating


Tuesday, March 11 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Tuesday, March 11 | 11:15AM - 12:15PM
Lunch
Room: Mezzanine 2


Tuesday, March 11 | 12:00PM - 2:30PM
Poster Session 2
Room: Mezzanine 2


Tuesday, March 11 | 2:30PM - 4:30PM
Panel 1: HIV/AIDS: Strategies for an Endgame (Joint)
Room: Van Horne Ballroom A/B
Keystone Symposia is pleased to present a panel discussion on the topic of 'HIV/AIDS: Strategies for an Endgame' moderated by Dr. Carl Dieffenbach, Director of the Division of AIDS Research at NIAID. The panel builds on discussions from our first virtual, live webcast on the same topic, originally broadcast in December of 2013, and offers opportunities for audience participation. The original webcast is being shown several times during the current meeting in the Shaughnessy Room and can also be viewed online at any time at www.visualwebcaster.com/KSHIV.
Speaker 1 of 7
* Carl W. Dieffenbach, NIAID, National Institutes of Health, USA

Tuesday, March 11 | 2:30PM - 4:30PM
Panel 1: HIV/AIDS: Strategies for an Endgame (Joint)
Room: Van Horne Ballroom A/B
Keystone Symposia is pleased to present a panel discussion on the topic of 'HIV/AIDS: Strategies for an Endgame' moderated by Dr. Carl Dieffenbach, Director of the Division of AIDS Research at NIAID. The panel builds on discussions from our first virtual, live webcast on the same topic, originally broadcast in December of 2013, and offers opportunities for audience participation. The original webcast is being shown several times during the current meeting in the Shaughnessy Room and can also be viewed online at any time at www.visualwebcaster.com/KSHIV.
Speaker 2 of 7
Galit Alter, MIT and Harvard University, USA

Tuesday, March 11 | 2:30PM - 4:30PM
Panel 1: HIV/AIDS: Strategies for an Endgame (Joint)
Room: Van Horne Ballroom A/B
Keystone Symposia is pleased to present a panel discussion on the topic of 'HIV/AIDS: Strategies for an Endgame' moderated by Dr. Carl Dieffenbach, Director of the Division of AIDS Research at NIAID. The panel builds on discussions from our first virtual, live webcast on the same topic, originally broadcast in December of 2013, and offers opportunities for audience participation. The original webcast is being shown several times during the current meeting in the Shaughnessy Room and can also be viewed online at any time at www.visualwebcaster.com/KSHIV.
Speaker 3 of 7
Peter A. Anton, David Geffen School of Medicine at UCLA, USA

Tuesday, March 11 | 2:30PM - 4:30PM
Panel 1: HIV/AIDS: Strategies for an Endgame (Joint)
Room: Van Horne Ballroom A/B
Keystone Symposia is pleased to present a panel discussion on the topic of 'HIV/AIDS: Strategies for an Endgame' moderated by Dr. Carl Dieffenbach, Director of the Division of AIDS Research at NIAID. The panel builds on discussions from our first virtual, live webcast on the same topic, originally broadcast in December of 2013, and offers opportunities for audience participation. The original webcast is being shown several times during the current meeting in the Shaughnessy Room and can also be viewed online at any time at www.visualwebcaster.com/KSHIV.
Speaker 4 of 7
Myron S. Cohen, University of North Carolina at Chapel Hill, USA

Tuesday, March 11 | 2:30PM - 4:30PM
Panel 1: HIV/AIDS: Strategies for an Endgame (Joint)
Room: Van Horne Ballroom A/B
Keystone Symposia is pleased to present a panel discussion on the topic of 'HIV/AIDS: Strategies for an Endgame' moderated by Dr. Carl Dieffenbach, Director of the Division of AIDS Research at NIAID. The panel builds on discussions from our first virtual, live webcast on the same topic, originally broadcast in December of 2013, and offers opportunities for audience participation. The original webcast is being shown several times during the current meeting in the Shaughnessy Room and can also be viewed online at any time at www.visualwebcaster.com/KSHIV.
Speaker 5 of 7
Magdalena E. Sobieszczyk, Columbia University, USA

Tuesday, March 11 | 2:30PM - 4:30PM
Panel 1: HIV/AIDS: Strategies for an Endgame (Joint)
Room: Van Horne Ballroom A/B
Keystone Symposia is pleased to present a panel discussion on the topic of 'HIV/AIDS: Strategies for an Endgame' moderated by Dr. Carl Dieffenbach, Director of the Division of AIDS Research at NIAID. The panel builds on discussions from our first virtual, live webcast on the same topic, originally broadcast in December of 2013, and offers opportunities for audience participation. The original webcast is being shown several times during the current meeting in the Shaughnessy Room and can also be viewed online at any time at www.visualwebcaster.com/KSHIV.
Speaker 6 of 7
David M. Margolis, University of North Carolina at Chapel Hill, USA

Tuesday, March 11 | 2:30PM - 4:30PM
Panel 1: HIV/AIDS: Strategies for an Endgame (Joint)
Room: Van Horne Ballroom A/B
Keystone Symposia is pleased to present a panel discussion on the topic of 'HIV/AIDS: Strategies for an Endgame' moderated by Dr. Carl Dieffenbach, Director of the Division of AIDS Research at NIAID. The panel builds on discussions from our first virtual, live webcast on the same topic, originally broadcast in December of 2013, and offers opportunities for audience participation. The original webcast is being shown several times during the current meeting in the Shaughnessy Room and can also be viewed online at any time at www.visualwebcaster.com/KSHIV.
Speaker 7 of 7
Thomas C. Quinn, NIAID and Johns Hopkins University, USA

Tuesday, March 11 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Tuesday, March 11 | 5:00PM - 7:15PM
Tackling Global HIV Diversity
Room: Van Horne Ballroom A/B

Speaker 1 of 7
* Richard A. Koup, NIAID, National Institutes of Health, USA

Tuesday, March 11 | 5:00PM - 7:15PM
Tackling Global HIV Diversity
Room: Van Horne Ballroom A/B

Speaker 2 of 7
* Edward A. Berger, NIAID, National Institutes of Health, USA

Tuesday, March 11 | 5:00PM - 7:15PM
Tackling Global HIV Diversity
Room: Van Horne Ballroom A/B

Speaker 3 of 7
Beatrice H. Hahn, University of Pennsylvania, USA
Phenotypic Properties of Transmitted Founder HIV-1

Tuesday, March 11 | 5:00PM - 7:15PM
Tackling Global HIV Diversity
Room: Van Horne Ballroom A/B

Speaker 4 of 7
Bette Tina Marie Korber, Los Alamos National Laboratory, USA
Using Signatures of Neutralizing Antibodies to Inform Vaccine Design

Tuesday, March 11 | 5:00PM - 7:15PM
Tackling Global HIV Diversity
Room: Van Horne Ballroom A/B

Speaker 5 of 7
Andrew B. Ward, The Scripps Research Institute, USA
High-Resolution Cryo-EM Studies of HIV-1 Env

Tuesday, March 11 | 5:00PM - 7:15PM
Tackling Global HIV Diversity
Room: Van Horne Ballroom A/B

Speaker 6 of 7
Dan H. Barouch, Beth Israel Deaconess Medical Center, USA
Short Talk: Prospects for Monoclonal Antibody Therapy for HIV-1

Tuesday, March 11 | 5:00PM - 7:15PM
Tackling Global HIV Diversity
Room: Van Horne Ballroom A/B

Speaker 7 of 7
Devin Sok, International AIDS Vaccine Initiative, USA
Short Talk: Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Facilitates Broader Neutralization of HIV

Tuesday, March 11 | 5:00PM - 7:00PM
Mechanistic Models of Pathogenesis and Disease
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 1 of 6
* Heinrich Gottlinger, University of Massachusetts Medical School, USA


Tuesday, March 11 | 5:00PM - 7:00PM
Mechanistic Models of Pathogenesis and Disease
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 2 of 6
* Shokrollah Elahi, University of Alberta, Canada


Tuesday, March 11 | 5:00PM - 7:00PM
Mechanistic Models of Pathogenesis and Disease
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 3 of 6
Richard T. D'Aquila, Northwestern University, USA
APOBEC3s versus Vif-Positive HIV-1: Tipping the Balance toward Virus Control


Tuesday, March 11 | 5:00PM - 7:00PM
Mechanistic Models of Pathogenesis and Disease
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 4 of 6
Timothy W. Schacker, University of Minnesota, USA
The Natural History of HIV Infection in Lymphatic Tissues


Tuesday, March 11 | 5:00PM - 7:00PM
Mechanistic Models of Pathogenesis and Disease
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 5 of 6
Anthony L. Cunningham, Westmead Institute for Medical Research, Australia
Short Talk: HIV Inhibits Interferon Production in Macrophages and Dendritic Cells but Exerts Other Antiviral Mechanisms


Tuesday, March 11 | 5:00PM - 7:00PM
Mechanistic Models of Pathogenesis and Disease
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 6 of 6
Anna Aldovini, Boston Children's Hospital and Harvard Medical School, USA
Short Talk: HIV-1 Tat Engagement of Different Promoters in Different Cell Types Results in Apoptosis of CD4+ T Cells and Activation of ISG Linked to Immune Activation in Antigen Presenting Cells


Tuesday, March 11 | 7:15PM - 7:15PM
On Own for Dinner


Wednesday, March 12 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Wednesday, March 12 | 8:00AM - 11:15AM
Novel Mechanisms for Vaccine-Induced Protection
Room: Van Horne Ballroom A/B

Speaker 1 of 8
* Genoveffa Franchini, NCI, National Institutes of Health, USA

Wednesday, March 12 | 8:00AM - 11:15AM
Novel Mechanisms for Vaccine-Induced Protection
Room: Van Horne Ballroom A/B

Speaker 2 of 8
* Jeffrey Robert Schneider, Northwestern University, USA

Wednesday, March 12 | 8:00AM - 11:15AM
Novel Mechanisms for Vaccine-Induced Protection
Room: Van Horne Ballroom A/B

Speaker 3 of 8
Silke Paust, Baylor College of Medicine, USA
NK Memory to Experimental HIV Vaccines in Mice and Humanized Mice

Wednesday, March 12 | 8:00AM - 11:15AM
Novel Mechanisms for Vaccine-Induced Protection
Room: Van Horne Ballroom A/B

Speaker 4 of 8
Galit Alter, MIT and Harvard University, USA
Fc-Signatures of Functional HIV-Specific Antibodies

Wednesday, March 12 | 8:00AM - 11:15AM
Novel Mechanisms for Vaccine-Induced Protection
Room: Van Horne Ballroom A/B

Speaker 5 of 8
Penny L. Moore, University of the Witwatersrand and National Institute for Communicable Diseases, South Africa
Evolution of V1V2 Broad Neutralizing Antibodies during HIV-1 Infection

Wednesday, March 12 | 8:00AM - 11:15AM
Novel Mechanisms for Vaccine-Induced Protection
Room: Van Horne Ballroom A/B

Speaker 6 of 8
Louis J. Picker, Oregon Health & Science University, USA
Effector Memory T-Cell Targeted Vaccines

Wednesday, March 12 | 8:00AM - 11:15AM
Novel Mechanisms for Vaccine-Induced Protection
Room: Van Horne Ballroom A/B

Speaker 7 of 8
Susan Johnson, US Military HIV Research Program, USA
Short Talk: HIV-Specific Cytolytic CD4 T Cells Are Distinct from Th1 Cells and Preserved in HIV Infection

Wednesday, March 12 | 8:00AM - 11:15AM
Novel Mechanisms for Vaccine-Induced Protection
Room: Van Horne Ballroom A/B

Speaker 8 of 8
Anna Aldovini, Boston Children's Hospital and Harvard Medical School, USA
Short Talk: Resistance to Infection, Early and Persistent Suppression of SIVmac251 Viremia and Significant Reduction of Tissue Viral Burden after Mucosal Vaccination in Females Rhesus macaques

Wednesday, March 12 | 8:00AM - 11:15AM
Host-Virus Interactions and Responses
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 1 of 8
* Paul R. Clapham, University of Massachusetts Medical School, USA


Wednesday, March 12 | 8:00AM - 11:15AM
Host-Virus Interactions and Responses
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 2 of 8
* Jaisri R. Lingappa, University of Washington, USA


Wednesday, March 12 | 8:00AM - 11:15AM
Host-Virus Interactions and Responses
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 3 of 8
Michael Emerman, Fred Hutchinson Cancer Research Center, USA
How Ancient Host-Virus Interactions Shaped the Modern HIV-1 Pandemic in Humans


Wednesday, March 12 | 8:00AM - 11:15AM
Host-Virus Interactions and Responses
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 4 of 8
Theodora Hatziioannou, Aaron Diamond AIDS Research Center (ADARC), USA
Restriction Factors and the Adaptation of HIV-1 to Non-Human Primates


Wednesday, March 12 | 8:00AM - 11:15AM
Host-Virus Interactions and Responses
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 5 of 8
Andrea Cimarelli, CIRI, International Center for Infectology Research, France
Exploring the Multiple Layers of Complexity Existing during the Early Phases of Infection of Myeloid Cells by Primate Lentiviruses


Wednesday, March 12 | 8:00AM - 11:15AM
Host-Virus Interactions and Responses
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 6 of 8
Reuben S. Harris, University of Minnesota, USA
Natural Resistance to HIV Infection by Select APOBEC3H Haplotypes


Wednesday, March 12 | 8:00AM - 11:15AM
Host-Virus Interactions and Responses
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 7 of 8
Daniel Claiborne, Ragon Institute of MGH, MIT, and Harvard, USA
Short Talk: Protective HLA Alleles Reduce Markers of Gut Damage and Microbial Translocation and Influence Early Inflammatory Cytokine Profiles


Wednesday, March 12 | 8:00AM - 11:15AM
Host-Virus Interactions and Responses
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 8 of 8
Rui Andre Raposo, George Washington University, USA
Short Talk: Increased Expression of Host Restriction Factors in HLA-B*57+ Individuals


Wednesday, March 12 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Wednesday, March 12 | 11:15AM - 12:45PM
Hands-On Computer Session on Los Alamos HIV Sequence Databas
e
Room: Beatty
Maximum attendance: 60 Interested participants may sign up at the meeting on a first-come, first-serve basis.
Speaker 1 of 3
* Brian T. Foley, Los Alamos National Lab, USA

Wednesday, March 12 | 11:15AM - 12:45PM
Hands-On Computer Session on Los Alamos HIV Sequence Databas
e
Room: Beatty
Maximum attendance: 60 Interested participants may sign up at the meeting on a first-come, first-serve basis.
Speaker 2 of 3
* Bette Tina Marie Korber, Los Alamos National Laboratory, USA

Wednesday, March 12 | 11:15AM - 12:45PM
Hands-On Computer Session on Los Alamos HIV Sequence Databas
e
Room: Beatty
Maximum attendance: 60 Interested participants may sign up at the meeting on a first-come, first-serve basis.
Speaker 3 of 3
* Will Fischer, Los Alamos National Laboratory, USA

Wednesday, March 12 | 11:15AM - 1:00PM
Poster Setup
Room: Mezzanine 2


Wednesday, March 12 | 12:45PM - 2:30PM
On Own for Lunch and Recreation


Wednesday, March 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Mezzanine 2


Wednesday, March 12 | 2:30PM - 4:30PM
Panel 2: Functions of Protective Antibodies
Room: Van Horne Ballroom A/B

Speaker 1 of 6
Stephen J. Kent, University of Melbourne, Australia

Wednesday, March 12 | 2:30PM - 4:30PM
Panel 2: Functions of Protective Antibodies
Room: Van Horne Ballroom A/B

Speaker 2 of 6
Margaret E. Ackerman, Dartmouth College, USA

Wednesday, March 12 | 2:30PM - 4:30PM
Panel 2: Functions of Protective Antibodies
Room: Van Horne Ballroom A/B

Speaker 3 of 6
Nancy L. Haigwood, Oregon Health & Science University, USA

Wednesday, March 12 | 2:30PM - 4:30PM
Panel 2: Functions of Protective Antibodies
Room: Van Horne Ballroom A/B

Speaker 4 of 6
Ruth M. Ruprecht, Texas Biomedical Research Institute, USA

Wednesday, March 12 | 2:30PM - 4:30PM
Panel 2: Functions of Protective Antibodies
Room: Van Horne Ballroom A/B

Speaker 5 of 6
James Arthos, NIAID, National Institutes of Health, USA

Wednesday, March 12 | 2:30PM - 4:30PM
Panel 2: Functions of Protective Antibodies
Room: Van Horne Ballroom A/B

Speaker 6 of 6
* Susan Zolla-Pazner, Icahn School of Medicine at Mount Sinai, USA

Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: It Is All in the Head: HIV, Macs, DCs and the CN
S
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 1 of 10
* Brenda L. Fredericksen, NIAID, National Institutes of Health, USA


Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: It Is All in the Head: HIV, Macs, DCs and the CN
S
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 2 of 10
* Pamela J. Skinner, University of Minnesota, USA


Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: It Is All in the Head: HIV, Macs, DCs and the CN
S
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 3 of 10
Joe Casazza, NIAID, National Institutes of Health, USA
Identification of HIV-Infected CD4+ T Cells using HIV RNA and Broadly Neutralizing Antibodies


Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: It Is All in the Head: HIV, Macs, DCs and the CN
S
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 4 of 10
Andrew N. Harman, Westmead Institute, Australia
The Role of Mucosal Dendritic Cells in HIV Infection


Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: It Is All in the Head: HIV, Macs, DCs and the CN
S
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 5 of 10
Rosa Camacho, Instituto Nacional de Enfermedades Respiratorias, Mexico
TNFalpha Overproduction by Conventional Dendritic Cells in Viremic versus Controller HIV Subjects


Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: It Is All in the Head: HIV, Macs, DCs and the CN
S
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 6 of 10
Alexandre Deshiere, Laval University, Canada
Transcriptomic and Proteomic Screening of Host Genes Modulated by HIV-1 in Human Macrophages: A Highly Sensitive Strategy for the Identification of New Susceptibility/Restriction Factors


Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: It Is All in the Head: HIV, Macs, DCs and the CN
S
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 7 of 10
Katharina Borm, Burnet Institute, Australia
Envelope Glycoprotein Determinants of Macrophages Tropism during Progressive HIV-1 Subtype C Infection


Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: It Is All in the Head: HIV, Macs, DCs and the CN
S
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 8 of 10
Maria Paz Gonzalez-Perez, UMASS, USA
HIV-1 R5 Envelopes from Brain and Immune Tissue of AIDS Patients with Normal Neurology are Less Functional and Less Macrophage-Tropic Compared to those in HAD Patients


Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: It Is All in the Head: HIV, Macs, DCs and the CN
S
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 9 of 10
Sheila M. Keating, GigaGen, USA
Cerebrospinal Fluid and Blood Inflammatory Biomarkers are Differentially Elevated in HIV and Neurological Disease


Wednesday, March 12 | 2:30PM - 4:30PM
Workshop 2: It Is All in the Head: HIV, Macs, DCs and the CN
S
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 10 of 10
David R. Graham, Johns Hopkins School of Medicine, USA
A Combined Proteomics and Metabolomics Study of CSF from HAND Patients Under cART Therapy Reveals Evidence for Ongoing Macrophage Activation and Pertubations in Glutamate Metabolism


Wednesday, March 12 | 3:30PM - 5:00PM
Keystone Symposia Webcast - HIV/AIDS: Strategies for an Endg
ame

Room: Shaughnessy
Taped rebroadcast of the first virtual Keystone Symposia event. This can also be viewed online at any time at www.visualwebcaster.com/KSHIV.

Wednesday, March 12 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Wednesday, March 12 | 5:00PM - 7:15PM
Engineering Protective Immune Responses
Room: Van Horne Ballroom A/B

Speaker 1 of 6
* Rena D. Astronomo, Fred Hutchinson Cancer Research Center, USA

Wednesday, March 12 | 5:00PM - 7:15PM
Engineering Protective Immune Responses
Room: Van Horne Ballroom A/B

Speaker 2 of 6
* Mark Connors, NIAID, National Institutes of Health, USA

Wednesday, March 12 | 5:00PM - 7:15PM
Engineering Protective Immune Responses
Room: Van Horne Ballroom A/B

Speaker 3 of 6
William Schief, International AIDS Vaccine Initiative and The Scripps Research Institute, USA
Vaccines to Induce Broadly Neutralizing Antibodies

Wednesday, March 12 | 5:00PM - 7:15PM
Engineering Protective Immune Responses
Room: Van Horne Ballroom A/B

Speaker 4 of 6
Nicholas M. Valiante, Novartis Vaccines and Diagnostics, USA
Minimal Essential Adjuvants: A Rational Approach for Optimizing Small Molecules as Vaccine Adjuvants

Wednesday, March 12 | 5:00PM - 7:15PM
Engineering Protective Immune Responses
Room: Van Horne Ballroom A/B

Speaker 5 of 6
Mario Roederer, NIAID, National Institutes of Health, USA
Antigenic Heterogeneity of Clonal Envelopes: A Novel Immune Evasion Mechanism

Wednesday, March 12 | 5:00PM - 7:15PM
Engineering Protective Immune Responses
Room: Van Horne Ballroom A/B

Speaker 6 of 6
Louise Scharf, California Institute of Technology, USA
Short Talk: A New Site of Broad Vulnerability on the HIV-1 Envelope Spike Defined by a Patient-Derived Antibody

Wednesday, March 12 | 5:00PM - 7:15PM
HIV, the Microbiome and the Mucosa
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 1 of 7
* Charles R. Rinaldo, University of Pittsburgh, USA


Wednesday, March 12 | 5:00PM - 7:15PM
HIV, the Microbiome and the Mucosa
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 2 of 7
* John C. Tilton, Case Western Reserve University, USA


Wednesday, March 12 | 5:00PM - 7:15PM
HIV, the Microbiome and the Mucosa
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 3 of 7
Dan R. Littman, HHMI/New York University School of Medicine, USA
Immue Homeostasis and Commensal Bacteria


Wednesday, March 12 | 5:00PM - 7:15PM
HIV, the Microbiome and the Mucosa
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 4 of 7
Nichole R. Klatt, University of Miami, USA
Kinetics of Mucosal Dysfunction after SIV Infection of Rhesus macaques


Wednesday, March 12 | 5:00PM - 7:15PM
HIV, the Microbiome and the Mucosa
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 5 of 7
Satya Dandekar, University of California, Davis, USA
HIV Pathogenesis: The GALT


Wednesday, March 12 | 5:00PM - 7:15PM
HIV, the Microbiome and the Mucosa
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 6 of 7
Brent E. Palmer, University of Colorado Health Sciences Center, USA
Short Talk: Alterations in the Gut Microbiota Associated with HIV Infection


Wednesday, March 12 | 5:00PM - 7:15PM
HIV, the Microbiome and the Mucosa
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 7 of 7
Hannah J. Barbian, University of Pennsylvania, USA
Short Talk: Evaluating the Enteric Virome as a Marker of Disease Progression in SIVcpz Infected Wild-Living Chimpanzees


Wednesday, March 12 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Mezzanine 2


Wednesday, March 12 | 7:30PM - 10:00PM
Poster Session 3
Room: Mezzanine 2


Thursday, March 13 | 7:00AM - 8:00AM
Breakfast
Room: Mezzanine 2


Thursday, March 13 | 8:00AM - 11:15AM
From Concepts to Implementation
Room: Van Horne Ballroom A/B

Speaker 1 of 8
* Liang Shang, University of Minnesota, USA

Thursday, March 13 | 8:00AM - 11:15AM
From Concepts to Implementation
Room: Van Horne Ballroom A/B

Speaker 2 of 8
* William A. Paxton, Institute of Infection and Global Health, UK

Thursday, March 13 | 8:00AM - 11:15AM
From Concepts to Implementation
Room: Van Horne Ballroom A/B

Speaker 3 of 8
Nicole Frahm, Bill & Melinda Gates Medical Research Institute, USA
Immunogenicity of HIV Vaccine Candidates in the HIV Vaccine Trials Network (HVTN)

Thursday, March 13 | 8:00AM - 11:15AM
From Concepts to Implementation
Room: Van Horne Ballroom A/B

Speaker 4 of 8
Magdalena E. Sobieszczyk, Columbia University, USA
Lessons from HVTN 505 Efficacy Trial of a DNA/rAd5 HIV Preventive Vaccine

Thursday, March 13 | 8:00AM - 11:15AM
From Concepts to Implementation
Room: Van Horne Ballroom A/B

Speaker 5 of 8
Jerome H. Kim, International Vaccine Institute, South Korea
RV144 and HIV Acquisition: Insights and New Questions

Thursday, March 13 | 8:00AM - 11:15AM
From Concepts to Implementation
Room: Van Horne Ballroom A/B

Speaker 6 of 8
Thomas C. Quinn, NIAID and Johns Hopkins University, USA
The Impact of Combination Prevention on the HIV Pandemic

Thursday, March 13 | 8:00AM - 11:15AM
From Concepts to Implementation
Room: Van Horne Ballroom A/B

Speaker 7 of 8
Susan Zolla-Pazner, Icahn School of Medicine at Mount Sinai, USA
Short Talk: IgG V3-Specific Antibody (Ab) Reactivity in Plasma from RV144: Implications for Vaccine Efficacy

Thursday, March 13 | 8:00AM - 11:15AM
From Concepts to Implementation
Room: Van Horne Ballroom A/B

Speaker 8 of 8
Iskra Tuero, Universidad Peruana Cayetano Heredia, Peru
Short Talk: SIV Trimeric versus Monomeric Env-Induced Antibodies and Delayed SIV Acquisition in Vaccinated Female Rhesus macaques

Thursday, March 13 | 8:00AM - 11:15AM
Reservoirs, Latency, Reactivation and Eradication
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 1 of 8
* Robert W. Buckheit, Jr., ImQuest BioSciences, Inc., USA


Thursday, March 13 | 8:00AM - 11:15AM
Reservoirs, Latency, Reactivation and Eradication
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 2 of 8
* Linda Chelico, University of Saskatchewan, Canada


Thursday, March 13 | 8:00AM - 11:15AM
Reservoirs, Latency, Reactivation and Eradication
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 3 of 8
Daria J. Hazuda, Merck Research Laboratories, USA
New Drug Targets in the Search for an HIV Cure


Thursday, March 13 | 8:00AM - 11:15AM
Reservoirs, Latency, Reactivation and Eradication
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 4 of 8
David M. Margolis, University of North Carolina at Chapel Hill, USA
HIV Eradication Approaches


Thursday, March 13 | 8:00AM - 11:15AM
Reservoirs, Latency, Reactivation and Eradication
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 5 of 8
Hiroyu Hatano, University of California, San Francisco, USA
HIV Persistence in 'Elite' Controllers


Thursday, March 13 | 8:00AM - 11:15AM
Reservoirs, Latency, Reactivation and Eradication
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 6 of 8
Steven Wolinsky, Northwestern University, USA
Persistent HIV-1 Replication and Evolution in Drug Sanctuaries within Peripheral Lymphoid Organ Compartments in Patients on Combination Antiretroviral Therapy


Thursday, March 13 | 8:00AM - 11:15AM
Reservoirs, Latency, Reactivation and Eradication
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 7 of 8
Edward A. Berger, NIAID, National Institutes of Health, USA
Short Talk: Novel CD4-Based Chimeric Antigen Receptors: Toward an HIV Functional Cure Using Genetically Modified CD8+ T Cells


Thursday, March 13 | 8:00AM - 11:15AM
Reservoirs, Latency, Reactivation and Eradication
This session is from HIV Pathogenesis
Room: Van Horne Ballroom C

Speaker 8 of 8
Scott G. Kitchen, University of California, Los Angeles AIDS Institute, USA
Short Talk: Engineering Stem Cells with Chimeric Antigen Receptors for HIV-Specific T Cell Immunity


Thursday, March 13 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Thursday, March 13 | 11:15AM - 12:45PM
Hands-On Computer Session on Los Alamos HIV Immunology Datab
ase
Room: Beatty
Maximum attendance: 60 Interested participants may sign up at the meeting on a first-come, first-serve basis.
Speaker 1 of 3
* Brian T. Foley, Los Alamos National Lab, USA

Thursday, March 13 | 11:15AM - 12:45PM
Hands-On Computer Session on Los Alamos HIV Immunology Datab
ase
Room: Beatty
Maximum attendance: 60 Interested participants may sign up at the meeting on a first-come, first-serve basis.
Speaker 2 of 3
* Bette Tina Marie Korber, Los Alamos National Laboratory, USA

Thursday, March 13 | 11:15AM - 12:45PM
Hands-On Computer Session on Los Alamos HIV Immunology Datab
ase
Room: Beatty
Maximum attendance: 60 Interested participants may sign up at the meeting on a first-come, first-serve basis.
Speaker 3 of 3
* Will Fischer, Los Alamos National Laboratory, USA

Thursday, March 13 | 12:45PM - 2:30PM
On Own for Lunch and Recreation


Thursday, March 13 | 2:30PM - 4:30PM
Panel 3: Triggering Protective B-Cell Responses
Room: Van Horne Ballroom A/B

Speaker 1 of 6
* George K. Lewis, University of Maryland, USA

Thursday, March 13 | 2:30PM - 4:30PM
Panel 3: Triggering Protective B-Cell Responses
Room: Van Horne Ballroom A/B

Speaker 2 of 6
M. Anthony Moody, Duke University Medical Center, USA

Thursday, March 13 | 2:30PM - 4:30PM
Panel 3: Triggering Protective B-Cell Responses
Room: Van Horne Ballroom A/B

Speaker 3 of 6
Rogier W. Sanders, University of Amsterdam and Weill Cornell Medical College, Netherlands
Neutralizing Antibodies Induced by a Soluble Cleaved HIV Envelope Trimer, BG505 SOSIP.664 gp140

Thursday, March 13 | 2:30PM - 4:30PM
Panel 3: Triggering Protective B-Cell Responses
Room: Van Horne Ballroom A/B

Speaker 4 of 6
Jens P. Wrammert, Emory University, USA
Interrogating SIV/HIV Specific Plasmablast Responses in Rhesus macaques

Thursday, March 13 | 2:30PM - 4:30PM
Panel 3: Triggering Protective B-Cell Responses
Room: Van Horne Ballroom A/B

Speaker 5 of 6
Alejandro Balazs, Massachusetts General Hospital, USA

Thursday, March 13 | 2:30PM - 4:30PM
Panel 3: Triggering Protective B-Cell Responses
Room: Van Horne Ballroom A/B

Speaker 6 of 6
Burton E. Barnett, Genomics Institute of the Novartis Research Foundation, USA

Thursday, March 13 | 3:30PM - 5:00PM
Keystone Symposia Webcast - HIV/AIDS: Strategies for an Endg
ame

Room: Shaughnessy
Taped rebroadcast of the first virtual Keystone Symposia event. This can also be viewed online at any time at www.visualwebcaster.com/KSHIV.

Thursday, March 13 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Foyer


Thursday, March 13 | 5:00PM - 6:45PM
Cellular and Genetic Therapies for HIV/AIDS (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 5
* Nicole Frahm, Bill & Melinda Gates Medical Research Institute, USA

Thursday, March 13 | 5:00PM - 6:45PM
Cellular and Genetic Therapies for HIV/AIDS (Joint)
Room: Van Horne Ballroom A/B

Speaker 2 of 5
* J. Victor Garcia-Martinez, University of North Carolina at Chapel Hill, USA

Thursday, March 13 | 5:00PM - 6:45PM
Cellular and Genetic Therapies for HIV/AIDS (Joint)
Room: Van Horne Ballroom A/B

Speaker 3 of 5
Robert F. Siliciano, Johns Hopkins University School of Medicine, USA
Prospects for HIV Eradication

Thursday, March 13 | 5:00PM - 6:45PM
Cellular and Genetic Therapies for HIV/AIDS (Joint)
Room: Van Horne Ballroom A/B

Speaker 4 of 5
Nicolas Chomont, Université de Montréal, Canada
HIV Persistence during ART: What Can We Learn from CD4 T Cell Homeostasis?

Thursday, March 13 | 5:00PM - 6:45PM
Cellular and Genetic Therapies for HIV/AIDS (Joint)
Room: Van Horne Ballroom A/B

Speaker 5 of 5
Jerome A. Zack, University of California, Los Angeles, USA
Novel Means for Eliminating Latent HIV Reservoirs

Thursday, March 13 | 6:45PM - 7:30PM
Keynote Address (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 1
Mark M. Davis, Stanford University School of Medicine, USA

Thursday, March 13 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Mezzanine 2


Thursday, March 13 | 8:00PM - 11:00PM
Entertainment
Room: Mezzanine 2


Thursday, March 13 | 8:00PM - 11:00PM
Cash Bar
Room: Mezzanine 2


Friday, March 14 | 10:25AM - 10:25AM
Departure


*Session Chair.