Web Desc
Tumor Metabolism
joint with Metabolism and Angiogenesis
Organizer(s): William G. Kaelin, Jr., Benjamin F. Cravatt III and Peter K. Jackson
Date: March 16 - 21, 2014
Location: Whistler Conference Centre, Whistler, BC, Canada
Sponsored by Bayer HealthCare Pharmaceuticals, Pfizer Inc., Takeda Pharmaceutical Company Limited and TESARO, Inc. Supported by an educational donation provided by Amgen.
Summary of Meeting:
The recent discovery of mutations affecting metabolic enzymes such as succinate dehydrogenase, fumarate hydratase and isocitrate dehydrogenase provides genetic evidence that altered cellular metabolism can cause cancer. Moreover, it has become apparent that a number of proteins that regulate processes pertinent to cellular transformation, such as enzymes that affect chromatin structure, respond to specific cellular metabolites. Finally, technologies for monitoring cellular metabolism are improving rapidly including technologies that lend themselves to non-invasive imaging. The goals of this meeting are to bring together a diverse group of scientists from academia and industry with basic and translational interests surrounding cancer metabolism. A particular focus will be on metabolic enzymes as potential targets for treating and/or imaging cancer cells. Toward this end this meeting engages a diverse group of scientists including biologists, chemists and engineers. This meeting provides participants with a greater understanding of the language and logic of cellular metabolism and provides a sense of the translational opportunities emerging from our growing knowledge of the role that altered metabolism plays in cancer.
Scholarship Deadline: November 18 2013
Discounted Abstract Deadline: November 18 2013
Abstract Deadline: December 17 2013
Discounted Registration Deadline: January 15 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Educational donation provided by AmgenBayer HealthCare PharmaceuticalsPfizer Inc.Takeda Pharmaceutical Company LimitedTESARO, Inc.
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Seahorse Bioscience, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Eli Lilly and Company
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA183152-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 16 | 4:00PM - 8:00PM
Arrival and Registration
Room: Sea to Sky Foyer


Monday, March 17 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Monday, March 17 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 1 of 2
M. Celeste Simon, University of Pennsylvania, USA
Oxygen, Lipids and Cancer Cell Metabolism

Monday, March 17 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 2 of 2
Steven L. McKnight, University of Texas Southwestern Medical Center, USA
Acetate Consumption as a Potential Vulnerability of Certain Types of Human Tumors

Monday, March 17 | 9:30AM - 9:50AM
Coffee Break
Room: Foyer


Monday, March 17 | 9:50AM - 12:30PM
Novel Metabolic Pathways in Cancer I (Joint)
Room: Sea to Sky B/C

Speaker 1 of 5
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Metabolic Pathways Important for Tumor Growth and Survival

Monday, March 17 | 9:50AM - 12:30PM
Novel Metabolic Pathways in Cancer I (Joint)
Room: Sea to Sky B/C

Speaker 2 of 5
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Amino Acids, Sugars and Cancer Metabolism

Monday, March 17 | 9:50AM - 12:30PM
Novel Metabolic Pathways in Cancer I (Joint)
Room: Sea to Sky B/C

Speaker 3 of 5
Karen H. Vousden, Francis Crick Institute, UK
p53-Pathway Mediated Metabolic Regulation

Monday, March 17 | 9:50AM - 12:30PM
Novel Metabolic Pathways in Cancer I (Joint)
Room: Sea to Sky B/C

Speaker 4 of 5
Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Metabolic Versatility in Cancer Cells

Monday, March 17 | 9:50AM - 12:30PM
Novel Metabolic Pathways in Cancer I (Joint)
Room: Sea to Sky B/C

Speaker 5 of 5
Douglas R. Green, St. Jude Children's Research Hospital, USA
Balancing Act: Caspases and RIP Kinases in Cell Death and Development

Monday, March 17 | 12:30PM - 1:00PM
Poster Setup
Room: Sea to Sky A


Monday, March 17 | 12:30PM - 5:00PM
On Own for Lunch and Recreation


Monday, March 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Monday, March 17 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, March 17 | 5:00PM - 7:00PM
Succinate Dehydrogenase and Fumarate Hydratase
Room: Sea to Sky C

Speaker 1 of 5
* Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA

Monday, March 17 | 5:00PM - 7:00PM
Succinate Dehydrogenase and Fumarate Hydratase
Room: Sea to Sky C

Speaker 2 of 5
Patrick J. Pollard, University of Edinburgh, UK
Oncometabolites: Linking Altered Metabolism With Cancer?

Monday, March 17 | 5:00PM - 7:00PM
Succinate Dehydrogenase and Fumarate Hydratase
Room: Sea to Sky C

Speaker 3 of 5
Eyal Gottlieb, Technion - Israel Institute of Technology, Israel
Revealing New Metabolic Networks in FH-Deficient Tumors

Monday, March 17 | 5:00PM - 7:00PM
Succinate Dehydrogenase and Fumarate Hydratase
Room: Sea to Sky C

Speaker 4 of 5
Navdeep S. Chandel, Northwestern University, USA
Targeting Mitochondrial Metabolism for Cancer Therapy

Monday, March 17 | 5:00PM - 7:00PM
Succinate Dehydrogenase and Fumarate Hydratase
Room: Sea to Sky C

Speaker 5 of 5
Paul-Joseph Penaflor Aspuria, Atara Biotherapeutics, Inc., USA
Short Talk: Succinate Dehydrogenase Inhibition Leads to Epithelial-Mesenchymal Transition and Reprogrammed Carbon Metabolism

Monday, March 17 | 5:00PM - 7:00PM
Metabolism and Angiogenesis: Bidirectional Cross-Talk
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 1 of 5
* Adrian L. Harris, University of Oxford, Weatherall Institute of Molecular Medicine, UK


Monday, March 17 | 5:00PM - 7:00PM
Metabolism and Angiogenesis: Bidirectional Cross-Talk
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 2 of 5
Zoltan P. Arany, University of Pennsylvania, USA
Endothelial PGC-1alpha Mediates Vascular Dysfunction in Diabetes


Monday, March 17 | 5:00PM - 7:00PM
Metabolism and Angiogenesis: Bidirectional Cross-Talk
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 3 of 5
Massimo Santoro, Vesalius Research Center, Belgium
Novel Non-Mitochondrial Redox Regulator in Endothelial Cells


Monday, March 17 | 5:00PM - 7:00PM
Metabolism and Angiogenesis: Bidirectional Cross-Talk
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 4 of 5
Luisa Iruela-Arispe, University of California, Los Angeles, USA
Endothelial VEGFR2 Signaling in Diabetes


Monday, March 17 | 5:00PM - 7:00PM
Metabolism and Angiogenesis: Bidirectional Cross-Talk
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 5 of 5
Markus Jabs, German Cancer Research Center, Germany
Short Talk: Notch Signaling Regulates Systemic Energy Metabolism


Monday, March 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Monday, March 17 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A


Tuesday, March 18 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Tuesday, March 18 | 8:00AM - 11:15AM
Isocitrate Dehydrogenase
Room: Sea to Sky C

Speaker 1 of 6
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
The von Hippel-Lindau Tumor Suppressor Protein: Insights into Oxygen Sensing and Cancer Metabolism

Tuesday, March 18 | 8:00AM - 11:15AM
Isocitrate Dehydrogenase
Room: Sea to Sky C

Speaker 2 of 6
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Epigenetic Control by Mutant IDH

Tuesday, March 18 | 8:00AM - 11:15AM
Isocitrate Dehydrogenase
Room: Sea to Sky C

Speaker 3 of 6
Elizabeth Maher, University of Texas Southwestern Medical Center, USA
Metabolic Imaging of IDH Mutant Brain Tumors

Tuesday, March 18 | 8:00AM - 11:15AM
Isocitrate Dehydrogenase
Room: Sea to Sky C

Speaker 4 of 6
Kate Yen, Auron Therapeutics, USA
AG-221 Offers a Survival Advantage in a Primary Human IDH2 Mutant AML Xenograft Model

Tuesday, March 18 | 8:00AM - 11:15AM
Isocitrate Dehydrogenase
Room: Sea to Sky C

Speaker 5 of 6
Christian Metallo, University of California, San Diego, USA
Short Talk: Exploiting Oncogenic IDH Mutations to Identify Therapeutic Targets and Annotate Compartmentalized Pathway Function

Tuesday, March 18 | 8:00AM - 11:15AM
Isocitrate Dehydrogenase
Room: Sea to Sky C

Speaker 6 of 6
Yoko Ogawara, National Cancer Center Research Institute, Japan
Short Talk: Critical Roles of the IDH2 Mutation in Development and Maintenance of Acute Myeloid Leukemia

Tuesday, March 18 | 8:00AM - 11:15AM
Metabolism and Vascular Branching
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 1 of 8
* Luisa Iruela-Arispe, University of California, Los Angeles, USA


Tuesday, March 18 | 8:00AM - 11:15AM
Metabolism and Vascular Branching
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 2 of 8
Michael Potente, Max Planck Institute for Heart and Lung Research, Germany
Linking Angiogenesis and Metabolism through FOXO Transcription Factors


Tuesday, March 18 | 8:00AM - 11:15AM
Metabolism and Vascular Branching
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 3 of 8
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Targeting Endothelial Metabolism: Principles and Strategies


Tuesday, March 18 | 8:00AM - 11:15AM
Metabolism and Vascular Branching
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 4 of 8
Annika Keller, Zurich University Hospital, Switzerland
Endothelial-Pericyte Signaling and Brain Disease


Tuesday, March 18 | 8:00AM - 11:15AM
Metabolism and Vascular Branching
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 5 of 8
Hilary A. Coller, University of California, Los Angeles, USA
Tumor Stromal Cells


Tuesday, March 18 | 8:00AM - 11:15AM
Metabolism and Vascular Branching
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 6 of 8
Kari K. Alitalo, University of Helsinki, Finland
VEGF-B in Metabolic Reprogramming and Cardiovascular Disease


Tuesday, March 18 | 8:00AM - 11:15AM
Metabolism and Vascular Branching
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 7 of 8
Peter D. Westenskow, The Scripps Research Institute, USA
Short Talk: Cone Photoreceptors Generate the Fatty Acid Amide Erucamide for Maintenance of the Ocular Vasculature


Tuesday, March 18 | 8:00AM - 11:15AM
Metabolism and Vascular Branching
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 8 of 8
Pengchun Yu, Yale School of Medicine, USA
Short Talk: Regulation of Lymphangiogenesis by FGF Signaling


Tuesday, March 18 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, March 18 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Tuesday, March 18 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, March 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Tuesday, March 18 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, March 18 | 5:00PM - 7:00PM
Lactate and Monocarboxylate Transporters
Room: Sea to Sky C

Speaker 1 of 4
Ubaldo E. Martinez Outschoorn, Thomas Jefferson University/Frontiers, USA
Talk Title to be Announced

Tuesday, March 18 | 5:00PM - 7:00PM
Lactate and Monocarboxylate Transporters
Room: Sea to Sky C

Speaker 2 of 4
Jacques Pouysségur, University of Nice, France
Targeting Lactate/H+ Symporters for Cancer Therapy

Tuesday, March 18 | 5:00PM - 7:00PM
Lactate and Monocarboxylate Transporters
Room: Sea to Sky C

Speaker 3 of 4
John Kurhanewicz, University of California, San Francisco, USA
Using in Vivo Hyperpolarized 13C MR Imaging for Measuring Metabolic Fluxes Important to Prostate Cancer Progression and Therapeutic Response

Tuesday, March 18 | 5:00PM - 7:00PM
Lactate and Monocarboxylate Transporters
Room: Sea to Sky C

Speaker 4 of 4
Sunghee Park, Duke University Medical Center, USA
Short Talk: PGC-1alpha/ERRalpha Regulates Lactate-Fueled Mitochondrial Oxidative Metabolism in Breast Cancer

Tuesday, March 18 | 5:00PM - 7:00PM
Novel Metabolic Pathways in Cancer II
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 1 of 6
* M. Celeste Simon, University of Pennsylvania, USA


Tuesday, March 18 | 5:00PM - 7:00PM
Novel Metabolic Pathways in Cancer II
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 2 of 6
James M. Phang, NCI at Frederick, National Institutes of Health, USA
The Proline Regulatory Axis: Metabolic Reprogramming in Cancer


Tuesday, March 18 | 5:00PM - 7:00PM
Novel Metabolic Pathways in Cancer II
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 3 of 6
Yury I. Miller, University of California, San Diego, USA
Cholesterol Efflux and Angiogenesis


Tuesday, March 18 | 5:00PM - 7:00PM
Novel Metabolic Pathways in Cancer II
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 4 of 6
Hwee Ying Lim, National University of Singapore, Singapore
Role of Lymphatic Vessels in Cholesterol Clearance and the Involvement of High-Density Lipoproteins in Regulating Lymphatic Function


Tuesday, March 18 | 5:00PM - 7:00PM
Novel Metabolic Pathways in Cancer II
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 5 of 6
† Natalie Sheng Jie Lim, National University Singapore, Singapore
Short Talk: Strategy to Enhance Angiogenesis: A Prolyl Hydroxylase Inhibitor and Lysophospholipid Approach


Tuesday, March 18 | 5:00PM - 7:00PM
Novel Metabolic Pathways in Cancer II
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 6 of 6
Brian W. Wong, Washington University School of Medicine, USA
Short Talk: Investigating the Metabolism of Venous and Lymphatic Endothelial Cells


Tuesday, March 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Tuesday, March 18 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Wednesday, March 19 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Wednesday, March 19 | 7:30AM - 8:00AM
Poster Setup
Room: Sea to Sky A


Wednesday, March 19 | 8:00AM - 7:00PM
Poster Viewing
Room: Sea to Sky A


Wednesday, March 19 | 8:00AM - 11:15AM
Metabolism and Epigenetic Enzymes
Room: Sea to Sky C

Speaker 1 of 5
Lucy A. Godley, University of Chicago, USA
Regulation of Hematopoiesis by 5-Hydroxymethylcytosine

Wednesday, March 19 | 8:00AM - 11:15AM
Metabolism and Epigenetic Enzymes
Room: Sea to Sky C

Speaker 2 of 5
Chuan He, University of Chicago, USA
Epigenetic DNA and RNA Demethylation in Mammalian Regulation

Wednesday, March 19 | 8:00AM - 11:15AM
Metabolism and Epigenetic Enzymes
Room: Sea to Sky C

Speaker 3 of 5
Anne Brunet, Stanford University, USA
Metabolic and Epigenetic Regulation of Aging

Wednesday, March 19 | 8:00AM - 11:15AM
Metabolism and Epigenetic Enzymes
Room: Sea to Sky C

Speaker 4 of 5
Paul Guilhamon, University College London Cancer Institute, UK
Short Talk: Meta-Analysis of IDH-Mutant Cancers Identifies a New Interaction Partner for TET2

Wednesday, March 19 | 8:00AM - 11:15AM
Metabolism and Epigenetic Enzymes
Room: Sea to Sky C

Speaker 5 of 5
Hong-Wu Chen, University of California, Davis, USA
Short Talk: Reprogramming Metabolism for Cancer Therapeutic Resistance by Histone Methylases

Wednesday, March 19 | 8:00AM - 11:15AM
Metabolism and Anti-Angiogenic Therapy
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 1 of 6
Dai Fukumura, Massachusetts General Hospital, USA
Vascular Normalization and Metabolic Microenvironment


Wednesday, March 19 | 8:00AM - 11:15AM
Metabolism and Anti-Angiogenic Therapy
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 2 of 6
Patrizia Agostinis, KU Leuven, Belgium
Tumor Vessel Normalization by Chloroquine Independent on Autophagy Blockage


Wednesday, March 19 | 8:00AM - 11:15AM
Metabolism and Anti-Angiogenic Therapy
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 3 of 6
Olivier Feron, Université Catholique de Louvain, Belgium
Targeting Lactate and Glutamine Metabolism in Endothelial Cells


Wednesday, March 19 | 8:00AM - 11:15AM
Metabolism and Anti-Angiogenic Therapy
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 4 of 6
Adrian L. Harris, University of Oxford, Weatherall Institute of Molecular Medicine, UK
Metabolic Response to Anti-Angiogenic Therapy


Wednesday, March 19 | 8:00AM - 11:15AM
Metabolism and Anti-Angiogenic Therapy
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 5 of 6
Guy Eelen, Vesalius Research Center, KU Leuven, Belgium
Short Talk: Deletion of Glutamine Synthetase in Endothelial Cells Leads to Vessel Branching Defects


Wednesday, March 19 | 8:00AM - 11:15AM
Metabolism and Anti-Angiogenic Therapy
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 6 of 6
Stephanie M. Cossette, Medical College of Wisconsin, USA
Short Talk: Sucrose Non-Fermenting Related Kinase (SNRK) Is an AMPK Family Member that Is Essential for Cardiac Metabolism in vivo


Wednesday, March 19 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, March 19 | 11:15AM - 12:00PM
Lunch
Room: Sea to Sky A


Wednesday, March 19 | 12:00PM - 2:30PM
Poster Session 3
Room: Sea to Sky A


Wednesday, March 19 | 2:30PM - 4:30PM
Workshop: Monitoring Metabolism
Room: Sea to Sky C

Speaker 1 of 4
Hilary A. Coller, University of California, Los Angeles, USA
Metabolism of Quiescent Cells

Wednesday, March 19 | 2:30PM - 4:30PM
Workshop: Monitoring Metabolism
Room: Sea to Sky C

Speaker 2 of 4
Linda C. Hsieh-Wilson, California Institute of Technology, USA
The Interplay of Protein Glycosylation and Cancer Metabolism

Wednesday, March 19 | 2:30PM - 4:30PM
Workshop: Monitoring Metabolism
Room: Sea to Sky C

Speaker 3 of 4
Alan Saghatelian, The Salk Institute for Biological Studies, USA
Protein-Metabolite Interactions

Wednesday, March 19 | 2:30PM - 4:30PM
Workshop: Monitoring Metabolism
Room: Sea to Sky C

Speaker 4 of 4
Sakino Toue, Ajinomoto Co., Inc, Japan
Short Talk: MALDI-Imaging Mass Spectrometry Assisted by On-Tissue Chemical Derivatization for Visualizing Multiple Amino Acids in Human Colon Cancer Xenografts

Wednesday, March 19 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, March 19 | 5:00PM - 7:00PM
Lipid Metabolism
Room: Sea to Sky C

Speaker 1 of 4
Daniel K. Nomura, University of California, Berkeley, USA
Mapping Dyregulated Metabolic Pathways in Cancer Using Functional Proteomic and Metabolomic Platforms

Wednesday, March 19 | 5:00PM - 7:00PM
Lipid Metabolism
Room: Sea to Sky C

Speaker 2 of 4
Gerald Hoefler, Medical University of Graz, Austria
Adipose Triglyceride Lipase (ATGL) is a Metabolic Tumor Suppressor Gene

Wednesday, March 19 | 5:00PM - 7:00PM
Lipid Metabolism
Room: Sea to Sky C

Speaker 3 of 4
Ernst R. Lengyel, University of Chicago, USA
Crosstalk between Cancer Cells and Adipocytes

Wednesday, March 19 | 5:00PM - 7:00PM
Lipid Metabolism
Room: Sea to Sky C

Speaker 4 of 4
Jurre J. Kamphorst, Rheos Medicines, USA
Short Talk: Hypoxic and Ras-Transformed Cells Support Growth by Scavenging Fatty Acids from Lysophospholipids

Wednesday, March 19 | 5:00PM - 7:00PM
Metabolism and Pathological Angiogenesis
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 1 of 4
Yoshiaki Kubota, Keio University, Japan
Oxidative Stress as a Target for Anti-Angiogenic Therapy


Wednesday, March 19 | 5:00PM - 7:00PM
Metabolism and Pathological Angiogenesis
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 2 of 4
* Michael Simons, Yale University, USA
Vascular Fate Determination


Wednesday, March 19 | 5:00PM - 7:00PM
Metabolism and Pathological Angiogenesis
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 3 of 4
Massimiliano Mazzone, KU Leuven – VIB, Belgium
Influence of Macrophage Metabolism on Vessel Shape: Implications for Cancer


Wednesday, March 19 | 5:00PM - 7:00PM
Metabolism and Pathological Angiogenesis
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 4 of 4
Tony Walshe, Novartis, USA
Short Talk: Mitochondrial Oxidative Phosphorylation and Redox Signaling Govern Endothelial Cell Fate Decisions


Wednesday, March 19 | 7:00PM - 7:00PM
On Own for Dinner


Thursday, March 20 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Thursday, March 20 | 8:00AM - 11:00AM
Novel Cancer Metabolic Targets (Joint)
Room: Sea to Sky B/C

Speaker 1 of 6
Almut Schulze, University of Würzburg/Theodor-Boveri Institute, Germany
The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells

Thursday, March 20 | 8:00AM - 11:00AM
Novel Cancer Metabolic Targets (Joint)
Room: Sea to Sky B/C

Speaker 2 of 6
Jonathan Hurov, Agios Pharmaceuticals, USA
Investigation of Glutaminase (GLS1) Dependency in Cancer Cells

Thursday, March 20 | 8:00AM - 11:00AM
Novel Cancer Metabolic Targets (Joint)
Room: Sea to Sky B/C

Speaker 3 of 6
Thomas O'Brien, Pfizer, USA
and

Thursday, March 20 | 8:00AM - 11:00AM
Novel Cancer Metabolic Targets (Joint)
Room: Sea to Sky B/C

Speaker 4 of 6
Peter K. Jackson, Stanford University, USA
Inhibiting Glycolysis with a New LDHA Inhibitor

Thursday, March 20 | 8:00AM - 11:00AM
Novel Cancer Metabolic Targets (Joint)
Room: Sea to Sky B/C

Speaker 5 of 6
Brooke M. Emerling, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Deletion of Phosphatidylinositol-5-Phosphate 4-Kinases Results in Impaired Growth of p53 Deficient Tumors by Mediating Changes in Metabolism

Thursday, March 20 | 8:00AM - 11:00AM
Novel Cancer Metabolic Targets (Joint)
Room: Sea to Sky B/C

Speaker 6 of 6
Kristen E.N. Scott, H. Lee Moffitt Cancer Center & Research Institute, USA
Short Talk: De Novo Fatty Acid Synthesis Is Regulated by Myc and Is Required for B-Lymphoma Survival

Thursday, March 20 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, March 20 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Thursday, March 20 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, March 20 | 5:00PM - 7:00PM
Novel Cancer Metabolic Targets II
Room: Sea to Sky C

Speaker 1 of 3
Benjamin F. Cravatt III, The Scripps Research Institute, USA
Crosstalk between Metabolic and Signaling Pathways in Cancer

Thursday, March 20 | 5:00PM - 7:00PM
Novel Cancer Metabolic Targets II
Room: Sea to Sky C

Speaker 2 of 3
Sandaruwan Geeganage, Eli Lilly and Company, USA
Targeting Metabolic Reprogramming for Cancer – A Pharma Perspective

Thursday, March 20 | 5:00PM - 7:00PM
Novel Cancer Metabolic Targets II
Room: Sea to Sky C

Speaker 3 of 3
Nissim Hay, University of Illinois at Chicago, USA
Targeting Glucose Metabolism for Cancer Therapy

Thursday, March 20 | 5:00PM - 7:00PM
Metabolism and Angiogenesis: Therapeutic Implications
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 1 of 5
* Massimiliano Mazzone, KU Leuven – VIB, Belgium


Thursday, March 20 | 5:00PM - 7:00PM
Metabolism and Angiogenesis: Therapeutic Implications
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 2 of 5
Sara Zanivan, CRUK Beatson Institute, UK
Elucidating Endothelial Metabolism Using Quantitative Proteomics


Thursday, March 20 | 5:00PM - 7:00PM
Metabolism and Angiogenesis: Therapeutic Implications
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 3 of 5
Ulrike Harjes, University of Oxford, UK
Dll4-Notch and Foxo1 Co-Regulate Endothelial Fatty Acid Binding Protein 4


Thursday, March 20 | 5:00PM - 7:00PM
Metabolism and Angiogenesis: Therapeutic Implications
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 4 of 5
Miguel Quintela-Fandino, Spanish National Cancer Research Centre, Spain
Short Talk: Metabolic Synthetic Lethality: Antiangiogenic Treatment Plus Phenformin in Breast Cancer


Thursday, March 20 | 5:00PM - 7:00PM
Metabolism and Angiogenesis: Therapeutic Implications
This session is from Metabolism & Angiogenesis
Room: Sea to Sky B

Speaker 5 of 5
Anuradha Doddaballapur, Institute of Cardiovascular Regeneration, Germany
Short Talk: Shear Stress and Krüppel-Like Factor 2 Regulate Endothelial Metabolism by Repressing PFKFB3


Thursday, March 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Thursday, March 20 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A


Thursday, March 20 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Friday, March 21 | 10:25AM - 10:25AM
Departure


*Session Chair.