Web Desc
Innate Immunity, Metabolism and Vascular Injury
joint with Complications of Diabetes
Organizer(s): Ajay Chawla, Peter Tontonoz and Gwendalyn J. Randolph
Date: March 23 - 28, 2014
Location: Whistler Conference Centre, Whistler, BC, Canada
Supported by an educational donation provided by Amgen
Summary of Meeting:
A chronic low-grade inflammatory response is a defining feature of various metabolic diseases, including atherosclerosis, obesity, and type 2 diabetes. This smoldering inflammation in tissues, whether it is in the vascular bed, white adipose tissue or perivascular fat, is primarily mediated by the innate immune system. Consequently, this Keystone Symposium on Innate Immunity, Metabolism and Vascular Injury will bring together leading investigators in areas of macrophage biology, vascular inflammation, atherosclerosis, and obesity-induced metabolic disease. Sessions will encompass a broad range of topics highlighting the importance of and mechanisms by which innate immunity contributes to progression of metabolic diseases, including monocyte development and trafficking, macrophage activation in vascular bed and adipose tissues, and systems biology of myeloid cells. Exciting new developments in sensing of metabolic stress by inflammasomes, clearance of apoptotic cells by macrophages, and initiation of necrotic cell death programs will also be discussed. These basic studies will be complemented by talks discussing new strategies for promoting plaque regression, and targeting innate inflammation to treat insulin resistance, type 2 diabetes, and coronary artery disease.
Scholarship Deadline: November 21 2013
Discounted Abstract Deadline: November 21 2013
Abstract Deadline: December 19 2013
Discounted Registration Deadline: January 23 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Educational donation provided by Amgen.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
S. Karger AG - Journal of Innate Immunity
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL121792-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 23 | 4:00PM - 8:00PM
Arrival and Registration
Room: Grand Foyer


Sunday, March 23 | 6:00PM - 8:00PM
Welcome Mixer
Room: Grand Foyer


Monday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Monday, March 24 | 8:00AM - 9:00AM
Opening Remarks
Room: Sea to Sky C

Speaker 1 of 3
Ajay Chawla, Merck Research Labs, USA

Monday, March 24 | 8:00AM - 9:00AM
Opening Remarks
Room: Sea to Sky C

Speaker 2 of 3
Peter Tontonoz, University of California, Los Angeles, USA

Monday, March 24 | 8:00AM - 9:00AM
Opening Remarks
Room: Sea to Sky C

Speaker 3 of 3
Gwendalyn J. Randolph, Washington University, USA

Monday, March 24 | 8:00AM - 8:15AM
Opening Remarks
This session is from Complications of Diabetes

Speaker 1 of 1
Michael A. Brownlee, Albert Einstein College of Medicine, USA


Monday, March 24 | 8:15AM - 10:45AM
Monocytes: Development and Disease
Room: Sea to Sky C

Speaker 1 of 6
* Gwendalyn J. Randolph, Washington University, USA

Monday, March 24 | 8:15AM - 10:45AM
Monocytes: Development and Disease
Room: Sea to Sky C

Speaker 2 of 6
Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Developmental and Functional Heterogeneity of Macrophages

Monday, March 24 | 8:15AM - 10:45AM
Monocytes: Development and Disease
Room: Sea to Sky C

Speaker 3 of 6
Filip K. Swirski, Massachusetts General Hospital, USA
The Monocyte Lineage in Atherosclerosis

Monday, March 24 | 8:15AM - 10:45AM
Monocytes: Development and Disease
Room: Sea to Sky C

Speaker 4 of 6
Alan R. Tall, Columbia University, USA
Regulation of Hematopoiesis by Cholesterol

Monday, March 24 | 8:15AM - 10:45AM
Monocytes: Development and Disease
Room: Sea to Sky C

Speaker 5 of 6
Tiffany Horng, ShanghaiTech University, China
Short Talk: The TSC-mTOR Pathway Regulates Macrophage Polarization

Monday, March 24 | 8:15AM - 10:45AM
Monocytes: Development and Disease
Room: Sea to Sky C

Speaker 6 of 6
Partha Dutta, Massachusetts General Hospital Harvard Medical School, USA
Short Talk: Activation of CCR2+ Hematopoietic Stem Cells after Myocardial Infarction

Monday, March 24 | 9:15AM - 11:30AM
Metabolic Dysregulation and the Pathogenesis of Diabetic Car
diovascular Disease
This session is from Complications of Diabetes

Room: Sea to Sky B
Dysreguation of metabolism and impaired heart and vascular function. Defining the pathways contributing to impaired cardiovascular function and opportinuties to correct this will be the focus of this session.
Speaker 1 of 5
* Susan Quaggin, Northwestern University, USA


Monday, March 24 | 9:15AM - 11:30AM
Metabolic Dysregulation and the Pathogenesis of Diabetic Car
diovascular Disease
This session is from Complications of Diabetes

Room: Sea to Sky B
Dysreguation of metabolism and impaired heart and vascular function. Defining the pathways contributing to impaired cardiovascular function and opportinuties to correct this will be the focus of this session.
Speaker 2 of 5
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipocyte Origin of Insulin Resistance, Chronic Inflammation and Lipotoxicity


Monday, March 24 | 9:15AM - 11:30AM
Metabolic Dysregulation and the Pathogenesis of Diabetic Car
diovascular Disease
This session is from Complications of Diabetes

Room: Sea to Sky B
Dysreguation of metabolism and impaired heart and vascular function. Defining the pathways contributing to impaired cardiovascular function and opportinuties to correct this will be the focus of this session.
Speaker 3 of 5
Richard J.M. Coward, University of Bristol, UK
Insulin Resistance and the Kidney


Monday, March 24 | 9:15AM - 11:30AM
Metabolic Dysregulation and the Pathogenesis of Diabetic Car
diovascular Disease
This session is from Complications of Diabetes

Room: Sea to Sky B
Dysreguation of metabolism and impaired heart and vascular function. Defining the pathways contributing to impaired cardiovascular function and opportinuties to correct this will be the focus of this session.
Speaker 4 of 5
Christopher B. Newgard, Duke University Medical Center, USA
Metabolomics and Cardiometabolic Disease Mechanisms


Monday, March 24 | 9:15AM - 11:30AM
Metabolic Dysregulation and the Pathogenesis of Diabetic Car
diovascular Disease
This session is from Complications of Diabetes

Room: Sea to Sky B
Dysreguation of metabolism and impaired heart and vascular function. Defining the pathways contributing to impaired cardiovascular function and opportinuties to correct this will be the focus of this session.
Speaker 5 of 5
Kyoungmin Park, Joslin Diabetes Center, USA
Short Talk: Direct Demonstration that Overexpression of IRS1 and Enhanced Insulin Actions in Vascular Endothelial Cells Can Reduce Atherosclerosis via a Novel Pathway to Activate eNOS


Monday, March 24 | 9:40AM - 10:00AM
Coffee Break
Room: Grand Foyer


Monday, March 24 | 11:45AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Monday, March 24 | 11:45AM - 2:30PM
On Own for Lunch and Recreation


Monday, March 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Monday, March 24 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 1 of 7
* Ichiro Manabe, Chiba University, Japan

Monday, March 24 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 2 of 7
Miyako Tanaka, Nagoya University, Japan
Mincle, a Novel Pathogen Sensor in Macrophages, Underlies Obesity-Induced Adipose Tissue Fibrosis in Mice

Monday, March 24 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 3 of 7
Joel D. Schilling, Washington University School of Medicine, USA
Inflammatory-Metabolic Crosstalk in Macrophages: The Role of the Lysosome

Monday, March 24 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 4 of 7
Bruno M. Carvalho, University of Pernambuco, Brazil
Splenic Monocytes and Macrophages Mediate Insulin Resistance in Obesity

Monday, March 24 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 5 of 7
Dario A. Gutierrez, TCR2, USA
Kit Deficiency, But Not Lack of Mast Cells, Has a Profound Effect on Adiposity and Obesity-Induced Insulin Resistance

Monday, March 24 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 6 of 7
Anca Dana E. Dobrian, Eastern Virginia Medical School, USA
Signal Transducer and Activator 4 (STAT4) Deficiency in Subsets of Hematopoietic Cells Improves Metabolic Phenotype by Reducing Adipose Tissue and Islet Inflammation in Obesity and Insulin Resistance

Monday, March 24 | 2:30PM - 4:30PM
Workshop 1
Room: Sea to Sky C

Speaker 7 of 7
Jonathan R. Brestoff, Perelman School of Medicine, University of Pennsylvania, USA
Group 2 Innate Lymphoid Cell Responses in White Adipose Tissue Are Conserved in Mice and Humans

Monday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Monday, March 24 | 5:00PM - 7:00PM
Genomics of Myeloid Cells
Room: Sea to Sky C

Speaker 1 of 5
* Alan R. Tall, Columbia University, USA

Monday, March 24 | 5:00PM - 7:00PM
Genomics of Myeloid Cells
Room: Sea to Sky C

Speaker 2 of 5
Christopher K. Glass, University of California, San Diego, USA
A Genome-Wide View of Macrophage Activation

Monday, March 24 | 5:00PM - 7:00PM
Genomics of Myeloid Cells
Room: Sea to Sky C

Speaker 3 of 5
Laszlo Nagy, Sanford-Burnham Medical Research Institute at Lake Nona, USA
The Genomic Basis of a Retinoid X Receptor-Induced Angiogenic Macrophage Phenotype

Monday, March 24 | 5:00PM - 7:00PM
Genomics of Myeloid Cells
Room: Sea to Sky C

Speaker 4 of 5
Chih-Hao Lee, Harvard University School of Public Health, USA
Serum Lipidome in Metabolic and Immune Functions

Monday, March 24 | 5:00PM - 7:00PM
Genomics of Myeloid Cells
Room: Sea to Sky C

Speaker 5 of 5
Ekaterina K. Koltsova, Fox Chase Cancer Center, USA
Short Talk: Interleukin-27 Signaling Curbs Inflammation in Atherosclerosis

Monday, March 24 | 5:00PM - 7:00PM
Stem Cells in Diabetic Tissue Repair I
This session is from Complications of Diabetes
Room: Sea to Sky B
Impaired tissues repair is a hallmark of the diabetic state. Recent studies suggest impaired stem cell mobilization may contribute. This session overview the contribution of stem-cell 'opathy' to diabetic complications.
Speaker 1 of 5
* Michael A. Brownlee, Albert Einstein College of Medicine, USA


Monday, March 24 | 5:00PM - 7:00PM
Stem Cells in Diabetic Tissue Repair I
This session is from Complications of Diabetes
Room: Sea to Sky B
Impaired tissues repair is a hallmark of the diabetic state. Recent studies suggest impaired stem cell mobilization may contribute. This session overview the contribution of stem-cell 'opathy' to diabetic complications.
Speaker 2 of 5
Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
Using iPS Cells to Investigate Complications in Type 1 Diabetes


Monday, March 24 | 5:00PM - 7:00PM
Stem Cells in Diabetic Tissue Repair I
This session is from Complications of Diabetes
Room: Sea to Sky B
Impaired tissues repair is a hallmark of the diabetic state. Recent studies suggest impaired stem cell mobilization may contribute. This session overview the contribution of stem-cell 'opathy' to diabetic complications.
Speaker 3 of 5
Geoffrey C. Gurtner, Stanford University, USA
Stem Cell Defects and Impaired Diabetic Wound Healing


Monday, March 24 | 5:00PM - 7:00PM
Stem Cells in Diabetic Tissue Repair I
This session is from Complications of Diabetes
Room: Sea to Sky B
Impaired tissues repair is a hallmark of the diabetic state. Recent studies suggest impaired stem cell mobilization may contribute. This session overview the contribution of stem-cell 'opathy' to diabetic complications.
Speaker 4 of 5
Andras Nagy, Mount Sinai Hospital, University of Toronto, Canada
Alternative Sources of Stem Cells for Tissue Repair


Monday, March 24 | 5:00PM - 7:00PM
Stem Cells in Diabetic Tissue Repair I
This session is from Complications of Diabetes
Room: Sea to Sky B
Impaired tissues repair is a hallmark of the diabetic state. Recent studies suggest impaired stem cell mobilization may contribute. This session overview the contribution of stem-cell 'opathy' to diabetic complications.
Speaker 5 of 5
Mattia Albiero, Venetian Institute of Molecular Medicine, Italy
Short Talk: Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1


Monday, March 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Monday, March 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky A


Tuesday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Tuesday, March 25 | 8:00AM - 11:15AM
Macrophages and Vascular Inflammation (Joint)
Room: Sea to Sky B/C

Speaker 1 of 7
* Christopher K. Glass, University of California, San Diego, USA

Tuesday, March 25 | 8:00AM - 11:15AM
Macrophages and Vascular Inflammation (Joint)
Room: Sea to Sky B/C

Speaker 2 of 7
Kathryn J. Moore, New York University Medical Center, USA
The NLRP3 Inflammasome in Atherosclerosis and Diabetes: Activation from Within

Tuesday, March 25 | 8:00AM - 11:15AM
Macrophages and Vascular Inflammation (Joint)
Room: Sea to Sky B/C

Speaker 3 of 7
Christoph J. Binder, Medical University of Vienna, Austria
Innate Sensors of Oxidative Stress

Tuesday, March 25 | 8:00AM - 11:15AM
Macrophages and Vascular Inflammation (Joint)
Room: Sea to Sky B/C

Speaker 4 of 7
Ira Tabas, Columbia University, USA
Defective Inflammation Resolution in Atherosclerosis: Mechanisms and Therapeutic Opportunities

Tuesday, March 25 | 8:00AM - 11:15AM
Macrophages and Vascular Inflammation (Joint)
Room: Sea to Sky B/C

Speaker 5 of 7
Peter Tontonoz, University of California, Los Angeles, USA
Integration of Metabolism and Inflammation by LXRs

Tuesday, March 25 | 8:00AM - 11:15AM
Macrophages and Vascular Inflammation (Joint)
Room: Sea to Sky B/C

Speaker 6 of 7
Qian Li, Joslin Diabetes Center, USA
Short Talk: Acceleration of Atherosclerosis by Specific Deletion of Protein Kinase C Isoform in Macrophages: An Anti-Atherosclerotic Role for its Activation in Diabetes

Tuesday, March 25 | 8:00AM - 11:15AM
Macrophages and Vascular Inflammation (Joint)
Room: Sea to Sky B/C

Speaker 7 of 7
José J. Fuster, Boston University School of Medicine, USA
Short Talk: Non-Canonical Wnt Signaling Promotes Inflammatory Abdominal Aortic Aneurysm Formation

Tuesday, March 25 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Tuesday, March 25 | 11:15AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Tuesday, March 25 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Tuesday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Tuesday, March 25 | 5:00PM - 7:00PM
Inflammasomes in Metabolic Disease
Room: Sea to Sky C

Speaker 1 of 5
* Kathryn J. Moore, New York University Medical Center, USA

Tuesday, March 25 | 5:00PM - 7:00PM
Inflammasomes in Metabolic Disease
Room: Sea to Sky C

Speaker 2 of 5
Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia, USA
Talk Title to be Announced

Tuesday, March 25 | 5:00PM - 7:00PM
Inflammasomes in Metabolic Disease
Room: Sea to Sky C

Speaker 3 of 5
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Fatty Acid Activation of the Inflammasomes

Tuesday, March 25 | 5:00PM - 7:00PM
Inflammasomes in Metabolic Disease
Room: Sea to Sky C

Speaker 4 of 5
Vishva M. Dixit, Genentech, Inc., USA
The Inflammasome

Tuesday, March 25 | 5:00PM - 7:00PM
Inflammasomes in Metabolic Disease
Room: Sea to Sky C

Speaker 5 of 5
Jon A. Hagar, University of North Carolina at Chapel Hill, USA
Short Talk: Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

Tuesday, March 25 | 5:00PM - 7:00PM
Emerging Targets for the Treatment of Diabetic Complications


This session is from Complications of Diabetes

Room: Sea to Sky B

Speaker 1 of 5
* Karl Tryggvason, Karolinska Institutet, Sweden


Tuesday, March 25 | 5:00PM - 7:00PM
Emerging Targets for the Treatment of Diabetic Complications


This session is from Complications of Diabetes

Room: Sea to Sky B

Speaker 2 of 5
Susan Quaggin, Northwestern University, USA
Targeting the Tie2 Pathway for Diabetic Nephropathy


Tuesday, March 25 | 5:00PM - 7:00PM
Emerging Targets for the Treatment of Diabetic Complications


This session is from Complications of Diabetes

Room: Sea to Sky B

Speaker 3 of 5
Dean Li, University of Utah, USA
Vascular Inflammation


Tuesday, March 25 | 5:00PM - 7:00PM
Emerging Targets for the Treatment of Diabetic Complications


This session is from Complications of Diabetes

Room: Sea to Sky B

Speaker 4 of 5
Martin Friedlander, The Scripps Research Institute, USA
Endothelial Progenitor Cells and Diabetic Retinopathy


Tuesday, March 25 | 5:00PM - 7:00PM
Emerging Targets for the Treatment of Diabetic Complications


This session is from Complications of Diabetes

Room: Sea to Sky B

Speaker 5 of 5
Ulf P.E. Eriksson, Karolinska Institutet, Sweden
Short Talk: Targeting VEGF-B as a Treatment of Insulin Resistance, Type 2 Diabetes and Diabetic Co-Morbidities


Tuesday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Tuesday, March 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Wednesday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Wednesday, March 26 | 8:00AM - 9:00AM
Keynote Address
Room: Sea to Sky C

Speaker 1 of 2
* Ajay Chawla, Merck Research Labs, USA

Wednesday, March 26 | 8:00AM - 9:00AM
Keynote Address
Room: Sea to Sky C

Speaker 2 of 2
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Inflammation and Diseases of Homeostasis

Wednesday, March 26 | 8:00AM - 11:00AM
Clinical Therapies on the Horizon for Diabetic Complications
This session is from Complications of Diabetes
Room: Sea to Sky B
Several novel therapeutics are in phase 2 clinical trials. These trials should be completed by 2014 or earlier. This session will overview the rationale for and results of these trials.
Speaker 1 of 6
* David E. Kelley, Merck & Co., Inc., USA


Wednesday, March 26 | 8:00AM - 11:00AM
Clinical Therapies on the Horizon for Diabetic Complications
This session is from Complications of Diabetes
Room: Sea to Sky B
Several novel therapeutics are in phase 2 clinical trials. These trials should be completed by 2014 or earlier. This session will overview the rationale for and results of these trials.
Speaker 2 of 6
Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute, Canada
Cardiovascular Effects of GLP1R Agonists


Wednesday, March 26 | 8:00AM - 11:00AM
Clinical Therapies on the Horizon for Diabetic Complications
This session is from Complications of Diabetes
Room: Sea to Sky B
Several novel therapeutics are in phase 2 clinical trials. These trials should be completed by 2014 or earlier. This session will overview the rationale for and results of these trials.
Speaker 3 of 6
Matthew D. Breyer, Janssen Pharmaceutical Company, USA
Discovery of Novel Treatments for Diabetic Nephropathy


Wednesday, March 26 | 8:00AM - 11:00AM
Clinical Therapies on the Horizon for Diabetic Complications
This session is from Complications of Diabetes
Room: Sea to Sky B
Several novel therapeutics are in phase 2 clinical trials. These trials should be completed by 2014 or earlier. This session will overview the rationale for and results of these trials.
Speaker 4 of 6
James W. Russell, University of Maryland, USA
Nicotinamide Precursors as a Treatment in the Diabetic Nervous System


Wednesday, March 26 | 8:00AM - 11:00AM
Clinical Therapies on the Horizon for Diabetic Complications
This session is from Complications of Diabetes
Room: Sea to Sky B
Several novel therapeutics are in phase 2 clinical trials. These trials should be completed by 2014 or earlier. This session will overview the rationale for and results of these trials.
Speaker 5 of 6
Edward P. Feener, KalVista Pharmaceuticals, USA
Plasma Kallikrein Inhibitors for Diabetic Macular Edema


Wednesday, March 26 | 8:00AM - 11:00AM
Clinical Therapies on the Horizon for Diabetic Complications
This session is from Complications of Diabetes
Room: Sea to Sky B
Several novel therapeutics are in phase 2 clinical trials. These trials should be completed by 2014 or earlier. This session will overview the rationale for and results of these trials.
Speaker 6 of 6
Kevin G. Peters, Aerpio Pharmaceuticals, USA
Short Talk: Novel Approach to Treatment of Diabetic Macular Edema: Activating Tie2 by Inhibition of Vascular Endothelial Protein Tyrosine Phosphatase (VE-PTP)


Wednesday, March 26 | 9:00AM - 11:30AM
Innate Inflammation and Insulin Resistance
Room: Sea to Sky C

Speaker 1 of 6
* Ira Tabas, Columbia University, USA

Wednesday, March 26 | 9:00AM - 11:30AM
Innate Inflammation and Insulin Resistance
Room: Sea to Sky C

Speaker 2 of 6
Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Targeting Inflammation to Treat Metabolic Disease

Wednesday, March 26 | 9:00AM - 11:30AM
Innate Inflammation and Insulin Resistance
Room: Sea to Sky C

Speaker 3 of 6
Richard M. Locksley, HHMI/University of California, San Francisco, USA
Innate Helper Type 2 Cells (ILC2) and Metabolic Homeostasis

Wednesday, March 26 | 9:00AM - 11:30AM
Innate Inflammation and Insulin Resistance
Room: Sea to Sky C

Speaker 4 of 6
Ajay Chawla, Merck Research Labs, USA
Anticipatory Inflammation: Physiologic Functions and Pathologic Consequences

Wednesday, March 26 | 9:00AM - 11:30AM
Innate Inflammation and Insulin Resistance
Room: Sea to Sky C

Speaker 5 of 6
Dayoung Oh, University of Texas Southwestern Medical Center, USA
Short Talk: LTB4 Causes Macrophage-Mediated Inflammation and Directly Induces Insulin Resistance

Wednesday, March 26 | 9:00AM - 11:30AM
Innate Inflammation and Insulin Resistance
Room: Sea to Sky C

Speaker 6 of 6
James C. Lo, Weill Cornell Medicine, USA
Short Talk: Adipsin Is an Adipokine that Improves beta Cell Function in Diabetes

Wednesday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Wednesday, March 26 | 11:30AM - 5:00PM
On Own for Lunch and Recreation


Wednesday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Wednesday, March 26 | 5:00PM - 7:00PM
Apoptosis and Necrosis
Room: Sea to Sky C

Speaker 1 of 5
* Peter Tontonoz, University of California, Los Angeles, USA

Wednesday, March 26 | 5:00PM - 7:00PM
Apoptosis and Necrosis
Room: Sea to Sky C

Speaker 2 of 5
Yoshihiro Ogawa, Kyushu University, Japan
Role of Parenchymal-Stromal Cell Interaction in Metabolic Diseases

Wednesday, March 26 | 5:00PM - 7:00PM
Apoptosis and Necrosis
Room: Sea to Sky C

Speaker 3 of 5
Shigekazu Nagata, IFReC, Osaka University, Japan
Exposure of Phosphatidylserine and Phosphatidylserine-Dependent Engulfment of Apoptotic Cells

Wednesday, March 26 | 5:00PM - 7:00PM
Apoptosis and Necrosis
Room: Sea to Sky C

Speaker 4 of 5
Andrés Hidalgo, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Spain
Clearance of Aged Neutrophils

Wednesday, March 26 | 5:00PM - 7:00PM
Apoptosis and Necrosis
Room: Sea to Sky C

Speaker 5 of 5
A. Phillip West, Yale University School of Medicine, USA
Short Talk: Altered Mitochondrial DNA Dynamics Elicit a Cell-Intrinsic Antiviral Signaling Program

Wednesday, March 26 | 5:00PM - 6:25PM
Mitochondrial Biology
This session is from Complications of Diabetes
Room: Sea to Sky B

Speaker 1 of 4
* James W. Russell, University of Maryland, USA


Wednesday, March 26 | 5:00PM - 6:25PM
Mitochondrial Biology
This session is from Complications of Diabetes
Room: Sea to Sky B

Speaker 2 of 4
Navdeep S. Chandel, Northwestern University, USA
Physiological Roles of Mitochondrial Reactive Oxygen Species


Wednesday, March 26 | 5:00PM - 6:25PM
Mitochondrial Biology
This session is from Complications of Diabetes
Room: Sea to Sky B

Speaker 3 of 4
Melinda T. Coughlan, Baker IDI Heart & Diabetes Institute, Australia
Impaired Mitophagy Activity in Diabetic Nephropathy


Wednesday, March 26 | 5:00PM - 6:25PM
Mitochondrial Biology
This session is from Complications of Diabetes
Room: Sea to Sky B

Speaker 4 of 4
Moshe Levi, Georgetown University, USA
Short Talk: G Protein Coupled Receptor TGR5 Activation Prevents Kidney Disease in Mice with Obesity and Diabetes


Wednesday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A


Thursday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Thursday, March 27 | 8:00AM - 11:15AM
Where Are the Missing Genetics in Diabetic Complications? (J
oint)

Room: Sea to Sky B/C

Speaker 1 of 6
* Karl Tryggvason, Karolinska Institutet, Sweden
Search for Diabetic Nephropathy Susceptibility Genes

Thursday, March 27 | 8:00AM - 11:15AM
Where Are the Missing Genetics in Diabetic Complications? (J
oint)

Room: Sea to Sky B/C

Speaker 2 of 6
Caroline S. Fox, Merck Research Labs, USA
Using GWAS, Exome ChIP and Exome Sequencing as Tools for Understanding Kidney Disease

Thursday, March 27 | 8:00AM - 11:15AM
Where Are the Missing Genetics in Diabetic Complications? (J
oint)

Room: Sea to Sky B/C

Speaker 3 of 6
Michael G. Rosenfeld, University of California, San Diego, USA
Enhancer Codes and Regulated Gene Transcription in Development and Disease

Thursday, March 27 | 8:00AM - 11:15AM
Where Are the Missing Genetics in Diabetic Complications? (J
oint)

Room: Sea to Sky B/C

Speaker 4 of 6
Fredrik Bäckhed, University of Gothenburg, Sweden
Altered Gut Metagenome in Diabetes - Cause or Consequence

Thursday, March 27 | 8:00AM - 11:15AM
Where Are the Missing Genetics in Diabetic Complications? (J
oint)

Room: Sea to Sky B/C

Speaker 5 of 6
Claudiu V. Komorowsky, University Clinic Erlangen, Germany
Short Talk: Systems Genetics Facilitates Driver Identification in Human Diabetic Kidney Disease

Thursday, March 27 | 8:00AM - 11:15AM
Where Are the Missing Genetics in Diabetic Complications? (J
oint)

Room: Sea to Sky B/C

Speaker 6 of 6
Alexandre Stewart, University of Ottawa Heart Institute, Canada
Short Talk: IRF2BP2, A Novel Transcriptional Regulator of Innate Immunity and Cholesterol Metabolism

Thursday, March 27 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Thursday, March 27 | 11:15AM - 2:30PM
On Own for Lunch and Recreation


Thursday, March 27 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 1 of 8
* Christoph J. Binder, Medical University of Vienna, Austria

Thursday, March 27 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 2 of 8
Xin Rong, HHMI/University of California, Los Angeles, USA
LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

Thursday, March 27 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 3 of 8
Mark A. Gillespie, Institute for Systems Biology, USA
A Systems Approach to Identifying Promoter-Bound LXR Coregulators in Atherosclerosis

Thursday, March 27 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 4 of 8
Siroon Bekkering, Radboud UMC, Netherlands
oxLDL Augments Long-Term Pro-Inflammatory Cytokine Production and Foam Cell Formation via Epigenetic Histone Modifications of Monocytes

Thursday, March 27 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 5 of 8
Suneil K. Koliwad, University of California, San Francisco, USA
Saturated Fats Engage an IRE1 alpha-Dependent Pathway to Activate the NLRP3 Inflammasome in Murine Myeloid Cells

Thursday, March 27 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 6 of 8
Ryan Snodgrass, Goethe University Frankfurt, Germany
Hypoxia Augments Palmitate-Induced Proinflammatory Activation of Primary Human Macrophages

Thursday, March 27 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 7 of 8
Joseph J. Boyle, Imperial College London, UK
AMPK-ATF1 Regulated Transcription Integrates Iron and Lipid Metabolism in Mhem Macrophages in Vascular Self-Protection from Hemorrhage and Pharmacological Protection with Metformin

Thursday, March 27 | 2:30PM - 4:30PM
Workshop 2
Room: Sea to Sky C

Speaker 8 of 8
Maroof Hasan, Novartis Institutes for BioMedical Research, Switzerland
The Role of Trex1 in Immunometabolism and Autoimmune Disease

Thursday, March 27 | 2:30PM - 4:30PM
Workshop: External Funding for Diabetes Complications Resear
ch
This session is from Complications of Diabetes
Room: Sea to Sky B

Speaker 1 of 4
Teresa Jones, NIDDK, National Institutes of Health, USA


Thursday, March 27 | 2:30PM - 4:30PM
Workshop: External Funding for Diabetes Complications Resear
ch
This session is from Complications of Diabetes
Room: Sea to Sky B

Speaker 2 of 4
Christian Ketchum, NIDDK, National Institutes of Health, USA
Diabetic Complications Consortium (DiaComp)


Thursday, March 27 | 2:30PM - 4:30PM
Workshop: External Funding for Diabetes Complications Resear
ch
This session is from Complications of Diabetes
Room: Sea to Sky B

Speaker 3 of 4
Tracy Rankin, NIDDK, National Institutes of Health, USA


Thursday, March 27 | 2:30PM - 4:30PM
Workshop: External Funding for Diabetes Complications Resear
ch
This session is from Complications of Diabetes
Room: Sea to Sky B

Speaker 4 of 4
Helen D. Nickerson, Juvenile Diabetes Research Foundation, USA
JDRF Strategy and Priorities in Diabetic Complications


Thursday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Thursday, March 27 | 5:00PM - 7:00PM
Progressing Fat and Regressing Cholesterol
Room: Sea to Sky C

Speaker 1 of 5
* Ajay Chawla, Merck Research Labs, USA

Thursday, March 27 | 5:00PM - 7:00PM
Progressing Fat and Regressing Cholesterol
Room: Sea to Sky C

Speaker 2 of 5
Karine Clément, INSERM / Sorbonne Universite, France
Extracellular Matrix Remodeling of Adipose Tissue and Metabolic Homeostasis

Thursday, March 27 | 5:00PM - 7:00PM
Progressing Fat and Regressing Cholesterol
Room: Sea to Sky C

Speaker 3 of 5
Edward A. Fisher, New York University School of Medicine, USA
HDL and Atherosclerosis Regression: Getting Rid of Cholesterol and Macrophages from the Plaque

Thursday, March 27 | 5:00PM - 7:00PM
Progressing Fat and Regressing Cholesterol
Room: Sea to Sky C

Speaker 4 of 5
Gwendalyn J. Randolph, Washington University, USA
Blood and Lymphatic Vasculature Inflammation in Crohn's Disease

Thursday, March 27 | 5:00PM - 7:00PM
Progressing Fat and Regressing Cholesterol
Room: Sea to Sky C

Speaker 5 of 5
Rachel J. Roth Flach, Pfizer Inc., USA
Short Talk: Endothelial MAP4K4 Is a Novel Regulator of Vascular Inflammation and Atherosclerosis

Thursday, March 27 | 5:00PM - 7:00PM
Model Systems for Diabetic Complications
This session is from Complications of Diabetes
Room: Sea to Sky B
The complexity of the systemic effects of chronic hyperglycemia on the organism cannot be reproduced by cell culture. This session will review novel biological systems that can faciliate the study of diabetic complications.
Speaker 1 of 5
* Matthew D. Breyer, Janssen Pharmaceutical Company, USA


Thursday, March 27 | 5:00PM - 7:00PM
Model Systems for Diabetic Complications
This session is from Complications of Diabetes
Room: Sea to Sky B
The complexity of the systemic effects of chronic hyperglycemia on the organism cannot be reproduced by cell culture. This session will review novel biological systems that can faciliate the study of diabetic complications.
Speaker 2 of 5
Ross L. Cagan, Mount Sinai School of Medicine, USA
Modeling Diabetic Complications in Drosophila


Thursday, March 27 | 5:00PM - 7:00PM
Model Systems for Diabetic Complications
This session is from Complications of Diabetes
Room: Sea to Sky B
The complexity of the systemic effects of chronic hyperglycemia on the organism cannot be reproduced by cell culture. This session will review novel biological systems that can faciliate the study of diabetic complications.
Speaker 3 of 5
Jens Kroll, Medical Faculty Mannheim, Heidelberg University and DKFZ-ZMBH Alliance, Germany
Modeling Diabetic Complications in Zebrafish


Thursday, March 27 | 5:00PM - 7:00PM
Model Systems for Diabetic Complications
This session is from Complications of Diabetes
Room: Sea to Sky B
The complexity of the systemic effects of chronic hyperglycemia on the organism cannot be reproduced by cell culture. This session will review novel biological systems that can faciliate the study of diabetic complications.
Speaker 4 of 5
Thomas M. Coffman, NUS Duke Singapore, Singapore
Humanized Mouse Models of Diabetic Nephropathy


Thursday, March 27 | 5:00PM - 7:00PM
Model Systems for Diabetic Complications
This session is from Complications of Diabetes
Room: Sea to Sky B
The complexity of the systemic effects of chronic hyperglycemia on the organism cannot be reproduced by cell culture. This session will review novel biological systems that can faciliate the study of diabetic complications.
Speaker 5 of 5
Hermann Haller, Hannover Medical School, Germany
Short Talk: A Novel Rapid Animal Model in Zebrafish to Analyse Molecular Mechanisms of Proteinuria and to Identify and to Evaluate Drugs for CKD and Diabetic Nephropathy


Thursday, March 27 | 7:00PM - 7:15PM
Concluding Remarks
Room: Sea to Sky C

Speaker 1 of 3
Ajay Chawla, Merck Research Labs, USA

Thursday, March 27 | 7:00PM - 7:15PM
Concluding Remarks
Room: Sea to Sky C

Speaker 2 of 3
Peter Tontonoz, University of California, Los Angeles, USA

Thursday, March 27 | 7:00PM - 7:15PM
Concluding Remarks
Room: Sea to Sky C

Speaker 3 of 3
Gwendalyn J. Randolph, Washington University, USA

Thursday, March 27 | 7:00PM - 7:15PM
Concluding Remarks
This session is from Complications of Diabetes

Speaker 1 of 3
Michael A. Brownlee, Albert Einstein College of Medicine, USA


Thursday, March 27 | 7:00PM - 7:15PM
Concluding Remarks
This session is from Complications of Diabetes

Speaker 2 of 3
Matthew D. Breyer, Janssen Pharmaceutical Company, USA


Thursday, March 27 | 7:00PM - 7:15PM
Concluding Remarks
This session is from Complications of Diabetes

Speaker 3 of 3
Susan Quaggin, Northwestern University, USA


Thursday, March 27 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Sea to Sky A


Thursday, March 27 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky A


Thursday, March 27 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky A


Friday, March 28 | 10:25AM - 10:25AM
Departure


*Session Chair.