Web Desc
G Protein-Coupled Receptors: Structural Dynamics and Functional Implications
joint with Frontiers of Structural Biology
Organizer(s): Christopher G. Tate and Fiona H. Marshall
Date: March 30 - April 04, 2014
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by Arena Pharmaceuticals, Inc. and Theravance, Inc.
Summary of Meeting:
G protein-coupled receptors are essential for intercellular communication in multicellular organisms and they are also the targets for many drugs already in use or under development, for the treatment of, for example, cardiovascular disease, asthma, cancer, neurological dysfunction and metabolic disorders. The field of GPCR biology has undergone a radical transformation with the structure determination of over 15 different GPCRs, including the first complex of an activated GPCR bound to a heterotrimeric G protein. This wealth of structural detail is now being translated into both a deeper understanding of GPCR function and into the development of new therapeutics. Structure is, however, only capable of defining atomic details of particular conformational states of a receptor. This meeting will focus on how an integration of structural data and information from experiments that study molecular dynamics in vitro, in vivo and in silico can be integrated to form an in-depth view of GPCR function. In addition, key therapeutic areas of cancer, inflammation and disorders of the central nervous system will be highlighted in relation to the development of novel therapeutics targeting GPCRs.
Scholarship Deadline: December 4 2013
Discounted Abstract Deadline: December 4 2013
Abstract Deadline: January 8 2014
Discounted Registration Deadline: January 30 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Arena Pharmaceuticals, Inc.Theravance, Inc.
We gratefully acknowledge additional support for this conference from:
EvotecPromega Corporation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Heptares Therapeutics Ltd
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Biochemical Society / Biochemical Journal
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 30 | 4:00PM - 8:00PM
Arrival and Registration
Room: Golden Cliff


Sunday, March 30 | 6:00PM - 8:00PM
Welcome Mixer
Room: Golden Cliff


Monday, March 31 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, March 31 | 8:00AM - 8:10AM
Opening Remarks (Joint)
Room: Ballroom 1-3

Speaker 1 of 4
Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

Monday, March 31 | 8:00AM - 8:10AM
Opening Remarks (Joint)
Room: Ballroom 1-3

Speaker 2 of 4
Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

Monday, March 31 | 8:00AM - 8:10AM
Opening Remarks (Joint)
Room: Ballroom 1-3

Speaker 3 of 4
Andrew B. Ward, The Scripps Research Institute, USA

Monday, March 31 | 8:00AM - 8:10AM
Opening Remarks (Joint)
Room: Ballroom 1-3

Speaker 4 of 4
† Andrew B. Ward, The Scripps Research Institute, USA

Monday, March 31 | 8:10AM - 9:10AM
Keynote Address (Joint)
Room: Ballroom 1-3

Speaker 1 of 2
* Fiona H. Marshall, Heptares Therapeutics Ltd., UK

Monday, March 31 | 8:10AM - 9:10AM
Keynote Address (Joint)
Room: Ballroom 1-3

Speaker 2 of 2
Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA
Seven Transmembrane Receptors

Monday, March 31 | 9:10AM - 12:30PM
Cutting-Edge Biophysics to Study Membrane Protein Conformati
onal Changes (Joint)

Room: Ballroom 1-3

Speaker 1 of 6
* Reinhard Grisshammer, NIH/NINDS, USA

Monday, March 31 | 9:10AM - 12:30PM
Cutting-Edge Biophysics to Study Membrane Protein Conformati
onal Changes (Joint)

Room: Ballroom 1-3

Speaker 2 of 6
H. Eric Xu, Van Andel Institute, USA
Toward a Structure of Rhodopsin-Arrestin Complex: Challenges in XFEL Data Processing and Structure Solution

Monday, March 31 | 9:10AM - 12:30PM
Cutting-Edge Biophysics to Study Membrane Protein Conformati
onal Changes (Joint)

Room: Ballroom 1-3

Speaker 3 of 6
Petra Fromme, Arizona State University, USA
Femtosecond Nanocrystallography of Membrane Proteins

Monday, March 31 | 9:10AM - 12:30PM
Cutting-Edge Biophysics to Study Membrane Protein Conformati
onal Changes (Joint)

Room: Ballroom 1-3

Speaker 4 of 6
Wayne L. Hubbell, University of California, Los Angeles, USA
Site-Directed Spin Labeling Strategies to Explore Conformational Dynamics of GPCRs

Monday, March 31 | 9:10AM - 12:30PM
Cutting-Edge Biophysics to Study Membrane Protein Conformati
onal Changes (Joint)

Room: Ballroom 1-3

Speaker 5 of 6
Ron O. Dror, Stanford University, USA
Structural Basis for Allosteric Modulation of GPCRs

Monday, March 31 | 9:10AM - 12:30PM
Cutting-Edge Biophysics to Study Membrane Protein Conformati
onal Changes (Joint)

Room: Ballroom 1-3

Speaker 6 of 6
Martin J. Lohse, Max Delbrück Center for Molecular Medicine, Germany
In vivo Studies of GPCR Conformational Changes Using Fluorescence-Based Assays

Monday, March 31 | 9:40AM - 10:00AM
Coffee Break
Room: Ballroom Lobby


Monday, March 31 | 12:30PM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Monday, March 31 | 12:30PM - 2:30PM
On Own for Lunch and Recreation


Monday, March 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 2-3

Speaker 1 of 9
* Fiona H. Marshall, Heptares Therapeutics Ltd., UK

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 2-3

Speaker 2 of 9
* Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 2-3

Speaker 3 of 9
James H. Felce, University of Oxford, UK
GPCR Family Structure - Explained by Receptor Organisation?

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 2-3

Speaker 4 of 9
Marta Filizola, Icahn School of Medicine at Mount Sinai, USA
Associations between G Protein-Coupled Receptors in an Explicit Membrane Investigated by Massive Molecular Dynamics Simulations

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 2-3

Speaker 5 of 9
Kim C. Jonas, Imperial College London, UK
Single Molecule Analysis of GPCR Transactivation via PD-PALM Reveals Oligomeric Complexes that Regulate Signal Sensitivity

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 2-3

Speaker 6 of 9
Christoph Klenk, University of Zurich, Switzerland
A Generic System for Increased Expression and Stabilization of G Protein-Coupled Receptors by Directed Evolution

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 2-3

Speaker 7 of 9
Aashish Manglik, University of California, San Francisco, USA
Leveraging Combinational Biology Methods to Understand GPCR Function

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 2-3

Speaker 8 of 9
Susmith Mukund, Genentech, USA
Probing Mechanisms of Glucagon Receptor Inhibition by Antibodies

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
Room: Ballroom 2-3

Speaker 9 of 9
Dimitrios Stamou, University of Copenhagen, Denmark
Single-Molecule Conformational Dynamics and Direct Observation of Multiple GPCR Dimerization Interfaces

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Biology
Room: Ballroom 1

Speaker 1 of 7
* Christopher P. Jaroniec, Ohio State University, USA


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Biology
Room: Ballroom 1

Speaker 2 of 7
Andre A. S. T. Ribeiro, Columbia University, USA
Determination of Signaling Pathways in Proteins Through Network Theory


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Biology
Room: Ballroom 1

Speaker 3 of 7
Gydo van Zundert, Utrecht University, Netherlands
Integrative Modeling of Biomolecular Complexes: HADDOCKing with Cryo-EM Data


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Biology
Room: Ballroom 1

Speaker 4 of 7
Peter K. Kasson, University of Virginia, USA
And Yet it Moves: Molecular Simulation Combined with Spectroscopic Methods to Probe Dynamic Function


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Biology
Room: Ballroom 1

Speaker 5 of 7
Wyatt Strutz, NanoTemper Technologies, USA
Some like it Hot: Determination of Biomolecular Interactions Using MicroScale Thermophoresis


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Biology
Room: Ballroom 1

Speaker 6 of 7
Matteo Dal Peraro, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Unveiling the Structure of Pathogenic Macromolecular Machines Using Integrative Dynamic Modeling


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
This session is from Structural Biology
Room: Ballroom 1

Speaker 7 of 7
Yuba R. Bhandari, National Cancer Institute, USA
Three-Dimensional Structure Determination of Large RNAs Using Small-Angle X-Ray Scattering


Monday, March 31 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, March 31 | 5:00PM - 7:15PM
Family C and Frizzled GPCRs
Room: Ballroom 2-3

Speaker 1 of 5
* Brian K. Kobilka, Stanford University School of Medicine, USA

Monday, March 31 | 5:00PM - 7:15PM
Family C and Frizzled GPCRs
Room: Ballroom 2-3

Speaker 2 of 5
Jean-Philippe Pin, Montpellier University, France
Structural Dynamics of Metabotropic Glutamate Receptors

Monday, March 31 | 5:00PM - 7:15PM
Family C and Frizzled GPCRs
Room: Ballroom 2-3

Speaker 3 of 5
Robert Lütjens, Addex Therapeutics, Switzerland
Discovery of Allosteric Modulators of Metabotropic Glutamate Receptors

Monday, March 31 | 5:00PM - 7:15PM
Family C and Frizzled GPCRs
Room: Ballroom 2-3

Speaker 4 of 5
Gunnar Schulte, Karolinska Institutet, Sweden
New Insights into Frizzled Signaling through Heterotrimeric G Proteins

Monday, March 31 | 5:00PM - 7:15PM
Family C and Frizzled GPCRs
Room: Ballroom 2-3

Speaker 5 of 5
Vadim Cherezov, The Scripps Research Institute, USA
Structural Basis of Small Molecule Recognition by the Human Smoothened (Class Frizzled) 7TM

Monday, March 31 | 5:00PM - 7:15PM
Utilizing Next Generation Technologies for Structural Biolog
y
This session is from Structural Biology

Room: Ballroom 1

Speaker 1 of 6
* Kurt Wüthrich, ETH Zürich, Switzerland


Monday, March 31 | 5:00PM - 7:15PM
Utilizing Next Generation Technologies for Structural Biolog
y
This session is from Structural Biology

Room: Ballroom 1

Speaker 2 of 6
Aled M. Edwards, University of Toronto, Canada
Structural Genomics in Aid of Drug Discovery


Monday, March 31 | 5:00PM - 7:15PM
Utilizing Next Generation Technologies for Structural Biolog
y
This session is from Structural Biology

Room: Ballroom 1

Speaker 3 of 6
David P. Marciano, Stanford University, USA
Short Talk: Rational Design of Novel PPARG Modulators with HDX


Monday, March 31 | 5:00PM - 7:15PM
Utilizing Next Generation Technologies for Structural Biolog
y
This session is from Structural Biology

Room: Ballroom 1

Speaker 4 of 6
Ian A. Wilson, The Scripps Research Institute, USA
Multidisciplinary Approaches for Tackling Challenging Problems in Human Health and Disease


Monday, March 31 | 5:00PM - 7:15PM
Utilizing Next Generation Technologies for Structural Biolog
y
This session is from Structural Biology

Room: Ballroom 1

Speaker 5 of 6
Wayne A. Hendrickson, Columbia University, USA
Diversity of Transmembrane Ion Channels Explored in a Structural Genomics Approach


Monday, March 31 | 5:00PM - 7:15PM
Utilizing Next Generation Technologies for Structural Biolog
y
This session is from Structural Biology

Room: Ballroom 1

Speaker 6 of 6
Dmitry Lyumkis, The Salk Institute for Biological Studies, USA
Short Talk: Direct Detectors and Single Particle Dissection of Conformational and Compositional Heterogeneity


Monday, March 31 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch


Monday, March 31 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby/Wasatch


Tuesday, April 01 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
Room: Ballroom 2-3

Speaker 1 of 7
* Brigitte L. Kieffer, Douglas Institute, Canada

Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
Room: Ballroom 2-3

Speaker 2 of 7
Kaspar Hollenstein, Heptares Therapeutics, UK
Using Conformational Thermostabilization to Determine the Structures of Class B G Protein-Coupled Receptors

Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
Room: Ballroom 2-3

Speaker 3 of 7
Patrick M. Sexton, Monash University, Australia
GLP1 Receptor Signaling in Response to Peptides and Allosteric Modulators

Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
Room: Ballroom 2-3

Speaker 4 of 7
Kathleen M. Caron, University of North Carolina at Chapel Hill, USA
Role of RAMPs in Disease

Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
Room: Ballroom 2-3

Speaker 5 of 7
Jean-Pierre Vilardaga, University of Pittsburgh, USA
GPCR in Noncanonical Signaling Mode

Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
Room: Ballroom 2-3

Speaker 6 of 7
Maria H. Hauge, Copenhagen University, Denmark
Short Talk: Free Fatty Acid Receptor FFAR1/GPR40 - Combined Gq and Gs Signaling Mediates Hormone Secretion by Ago-Allosteric Super-Agonists

Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
Room: Ballroom 2-3

Speaker 7 of 7
Minyoung Park, Novo Nordisk Research Center, USA
Short Talk: Site-Specific Labeling on Ghrelin Receptor via Genetically-Encoded Unnatural Amino Acid

Tuesday, April 01 | 8:00AM - 11:00AM
Structural and Functional Insights through the Use of Hybrid
Methods
This session is from Structural Biology

Room: Ballroom 1

Speaker 1 of 5
* Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA


Tuesday, April 01 | 8:00AM - 11:00AM
Structural and Functional Insights through the Use of Hybrid
Methods
This session is from Structural Biology

Room: Ballroom 1

Speaker 2 of 5
Gregory Alushin, NHLBI, National Institutes of Health, USA
Hybrid Approaches to Define the Effect of GTP Hydrolysis and Taxol Binding on Microtubule Structure and Stability


Tuesday, April 01 | 8:00AM - 11:00AM
Structural and Functional Insights through the Use of Hybrid
Methods
This session is from Structural Biology

Room: Ballroom 1

Speaker 3 of 5
Susan S. Taylor, University of California, San Diego, USA
PKA: Assembly of Dynamic Isoform-Specific Macromolecular Signaling Complexes


Tuesday, April 01 | 8:00AM - 11:00AM
Structural and Functional Insights through the Use of Hybrid
Methods
This session is from Structural Biology

Room: Ballroom 1

Speaker 4 of 5
Kurt Wüthrich, ETH Zürich, Switzerland
Solution NMR Studies of GPCR Conformational Polymorphisms and Function-Related Rate Processes


Tuesday, April 01 | 8:00AM - 11:00AM
Structural and Functional Insights through the Use of Hybrid
Methods
This session is from Structural Biology

Room: Ballroom 1

Speaker 5 of 5
Ponni Rajagopal, University of Washington, USA
Short Talk: Hybrid Methodologies for Elucidating Structure and Function of a Chaperone


Tuesday, April 01 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Tuesday, April 01 | 11:15AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Tuesday, April 01 | 11:15AM - 2:30PM
On Own for Lunch and Recreation


Tuesday, April 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 2-3

Speaker 1 of 9
* Fiona H. Marshall, Heptares Therapeutics Ltd., UK

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 2-3

Speaker 2 of 9
* Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 2-3

Speaker 3 of 9
Benjamin R. Myers, University of Utah School of Medicine, USA
Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the 7TM Oncoprotein Smoothened

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 2-3

Speaker 4 of 9
Tony Ngo, University of California, San Diego, USA
N-Terminal Metalloprotease Processing Regulates Trafficking and Function of the Orphan G Protein-Coupled Receptor, GPR37L1

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 2-3

Speaker 5 of 9
Whitney M. Nolte, Pfizer, USA
A Small Molecule Potentiator of Orthosteric Ligand Activity at the Glucagon-Like Peptide-1 Receptor Acts through Covalent Modification

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 2-3

Speaker 6 of 9
M. Flori Sassano, University of North Carolina, USA
An Open-Source Platform for the Remarkably Facile Genome-Wide Interrogation of the Druggable GPCR-ome

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 2-3

Speaker 7 of 9
Silvia Sposini, Imperial College London, UK
Post-Endocytic Sorting of the Luteinizing Hormone Receptor is Mediated by a Novel APPL1-Dependent Mechanism

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 2-3

Speaker 8 of 9
Amantha Thathiah, Catholic University of Leuven, Belgium
GPCR Signaling Dysfunction in Alzheimer’s Disease

Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
Room: Ballroom 2-3

Speaker 9 of 9
Nagarajan Vaidehi, City of Hope National Medical Center, USA
Insights into Thermostability of G-protein Coupled Receptors

Tuesday, April 01 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, April 01 | 5:00PM - 7:00PM
New Insights into GPCR Signaling
Room: Ballroom 2-3

Speaker 1 of 5
* Roger K. Sunahara, University of California, San Diego, USA

Tuesday, April 01 | 5:00PM - 7:00PM
New Insights into GPCR Signaling
Room: Ballroom 2-3

Speaker 2 of 5
Arthur Christopoulos, Monash University, Australia
Orthosteric and Allosteric Ligand Biased Signaling

Tuesday, April 01 | 5:00PM - 7:00PM
New Insights into GPCR Signaling
Room: Ballroom 2-3

Speaker 3 of 5
Vsevolod V. Gurevich, Vanderbilt University, USA
Arrestin Shape-Shifting and Design of Signaling-Biased Mutants

Tuesday, April 01 | 5:00PM - 7:00PM
New Insights into GPCR Signaling
Room: Ballroom 2-3

Speaker 4 of 5
John J.G. Tesmer, University of Michigan, USA
Structure and Small Molecule Inhibition of G Protein-Coupled Receptor Kinases

Tuesday, April 01 | 5:00PM - 7:00PM
New Insights into GPCR Signaling
Room: Ballroom 2-3

Speaker 5 of 5
Kamila M. Skieterska, Ghent University, Belgium
Short Talk: Non-Degradative and Non-Lysine Mediated Ubiquitination of the Dopamine D4 Receptor

Tuesday, April 01 | 5:00PM - 7:00PM
Structural Biology of Cellular Processes and Complexes
This session is from Structural Biology
Room: Ballroom 1

Speaker 1 of 5
* Susan S. Taylor, University of California, San Diego, USA


Tuesday, April 01 | 5:00PM - 7:00PM
Structural Biology of Cellular Processes and Complexes
This session is from Structural Biology
Room: Ballroom 1

Speaker 2 of 5
Christopher P. Jaroniec, Ohio State University, USA
Structural and Dynamic Studies of Protein Assemblies by Solid State NMR Spectroscopy


Tuesday, April 01 | 5:00PM - 7:00PM
Structural Biology of Cellular Processes and Complexes
This session is from Structural Biology
Room: Ballroom 1

Speaker 3 of 5
Tatyana Polenova, University of Delaware, USA
Structure and Dynamics of Microtubule-Associated and HIV-1 Protein Assemblies by MAS NMR Spectroscopy


Tuesday, April 01 | 5:00PM - 7:00PM
Structural Biology of Cellular Processes and Complexes
This session is from Structural Biology
Room: Ballroom 1

Speaker 4 of 5
Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Structure-Function Studies of Cytosolic DNA Sensors Governing the Interferon Response


Tuesday, April 01 | 5:00PM - 7:00PM
Structural Biology of Cellular Processes and Complexes
This session is from Structural Biology
Room: Ballroom 1

Speaker 5 of 5
Nathan D. Thomsen, University of California, San Francisco, USA
Short Talk: Reading between the Lines: Trapping Transient Protein Conformers for Structural Analysis, Functional Proteomics and Therapeutic Discovery


Tuesday, April 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch


Tuesday, April 01 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby/Wasatch


Wednesday, April 02 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
Room: Ballroom 2-3

Speaker 1 of 7
* Martin J. Lohse, Max Delbrück Center for Molecular Medicine, Germany

Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
Room: Ballroom 2-3

Speaker 2 of 7
Mark von Zastrow, University of California, San Francisco, USA
GPCR Signaling from Endosomes

Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
Room: Ballroom 2-3

Speaker 3 of 7
Andrew B. Tobin, University of Glasgow, UK
Novel Animal Models to Define GPCR Therapeutic Potential

Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
Room: Ballroom 2-3

Speaker 4 of 7
Christopher G. Tate, MRC Laboratory of Molecular Biology, UK
The Structural Basis for Ligand Efficacy in the Beta1-Adrenoceptor

Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
Room: Ballroom 2-3

Speaker 5 of 7
Roger K. Sunahara, University of California, San Diego, USA
The Mechanism of G Protein Activation through Interactions with GPCRs and How Nucleotide Release from G Proteins in Turn Allosterically Modulates Ligand Binding at the Orthosteric Site

Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
Room: Ballroom 2-3

Speaker 6 of 7
Alexey Bondar, Institute of Nanobiology and Structural Biology, Czech Republic
Short Talk: In vivo Imaging and Quantitation of Interactions between Gi/o Protein Subunits and GPCRs by Two-Photon Polarization Microscopy

Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
Room: Ballroom 2-3

Speaker 7 of 7
Susanne Nuber, University of Würzburg, Germany
Short Talk: FRET Based beta-Arrestin2 Biosensors Reveal Receptor Specific Conformational Movements in Real Time and Living Cells

Wednesday, April 02 | 8:00AM - 11:00AM
Advances in Membrane Protein Structure Solution
This session is from Structural Biology
Room: Ballroom 1

Speaker 1 of 6
* John Briggs, European Molecular Biology Laboratory, Germany


Wednesday, April 02 | 8:00AM - 11:00AM
Advances in Membrane Protein Structure Solution
This session is from Structural Biology
Room: Ballroom 1

Speaker 2 of 6
Liz Carpenter, University of Oxford, UK
Structural Genomics of Human Membrane Proteins has Given Diverse Insights into ABC Transporter Function (ABCB10), Premature Aging (ZMPSTE24) and Channel Conformations (TREK-2)


Wednesday, April 02 | 8:00AM - 11:00AM
Advances in Membrane Protein Structure Solution
This session is from Structural Biology
Room: Ballroom 1

Speaker 3 of 6
Claus J. Loland, University of Copenhagen, Denmark
Short Talk: Investigating Conformational Changes in a Neurotransmitter Transporter Homologue with Transition Metal-Ion FRET


Wednesday, April 02 | 8:00AM - 11:00AM
Advances in Membrane Protein Structure Solution
This session is from Structural Biology
Room: Ballroom 1

Speaker 4 of 6
Andrew B. Ward, The Scripps Research Institute, USA
Structural Studies of Viral Envelope Proteins


Wednesday, April 02 | 8:00AM - 11:00AM
Advances in Membrane Protein Structure Solution
This session is from Structural Biology
Room: Ballroom 1

Speaker 5 of 6
Jennifer L. Johnson, Georgia Institute of Technology, USA
Short Talk: The Development of Engineered Crystallization Chaperones to Promote Membrane Protein Crystallization


Wednesday, April 02 | 8:00AM - 11:00AM
Advances in Membrane Protein Structure Solution
This session is from Structural Biology
Room: Ballroom 1

Speaker 6 of 6
John Rubinstein, University of Toronto, Canada
Electron Cryomicroscopy of Rotary ATPases


Wednesday, April 02 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Wednesday, April 02 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Wednesday, April 02 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Wednesday, April 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
This session is from Structural Biology
Room: Ballroom 1

Speaker 1 of 8
* Marc A. Elsliger, The Scripps Research Institute, USA
The Joint Center for Structural Genomics – A PSI:Biology Center for High-Throughput Structure Determination


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
This session is from Structural Biology
Room: Ballroom 1

Speaker 2 of 8
Kelly Kai Li Hew, Nanyang Technological University, Singapore
Systems Structural Biology on Human Herpesviruses


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
This session is from Structural Biology
Room: Ballroom 1

Speaker 3 of 8
Jürgen Haas, Swiss Institute of Bioinformatics, Switzerland
The ProteinModelPortal - How Good Is My Prediction? –First Results from the Continuous Automated Model EvaluatiOn (CAMEO)


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
This session is from Structural Biology
Room: Ballroom 1

Speaker 4 of 8
Allyn J. Schoeffler, Genentech, USA
The Dynamics of cIAP1 Are Precisely Tuned for Rapid Activation


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
This session is from Structural Biology
Room: Ballroom 1

Speaker 5 of 8
Ekaterina V. Filippova, Northwestern University, USA
Functional and Structural Characterization of GNAT Family of Acetyltransferases


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
This session is from Structural Biology
Room: Ballroom 1

Speaker 6 of 8
Jeong Hyun Lee, The Scripps Research Institute, USA
Rapidly Uncovering New Epitopes on Viral Envelope Glycoproteins Using EM


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
This session is from Structural Biology
Room: Ballroom 1

Speaker 7 of 8
Lenore Sparks, European Molecular Biology Laboratory, Germany
Positioning the Nup214 Subcomplex and Nup358 into the Human Nuclear Pore Complex


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
This session is from Structural Biology
Room: Ballroom 1

Speaker 8 of 8
Peter S. Lee, The Scripps Research Institute, USA
Head Hunting: Targeting the Influenza Hemagglutinin Receptor Binding Site


Wednesday, April 02 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, April 02 | 5:00PM - 7:00PM
Targeting GPCRs in Cancer and Inflammation
Room: Ballroom 2-3

Speaker 1 of 5
* Patrick M. Sexton, Monash University, Australia

Wednesday, April 02 | 5:00PM - 7:00PM
Targeting GPCRs in Cancer and Inflammation
Room: Ballroom 2-3

Speaker 2 of 5
Xavier J. Leroy, ITEOS Therapeutics, Belgium
FPR2 Agonists in Inflammatory Disease

Wednesday, April 02 | 5:00PM - 7:00PM
Targeting GPCRs in Cancer and Inflammation
Room: Ballroom 2-3

Speaker 3 of 5
Michael Hanson, GPCR Consortium, USA
S1P1 Receptor Structure and Ligand Analysis

Wednesday, April 02 | 5:00PM - 7:00PM
Targeting GPCRs in Cancer and Inflammation
Room: Ballroom 2-3

Speaker 4 of 5
Suzie Chen, Rutgers University, USA
Metabotropic Glutamate Receptor Signaling in Cancer

Wednesday, April 02 | 5:00PM - 7:00PM
Targeting GPCRs in Cancer and Inflammation
Room: Ballroom 2-3

Speaker 5 of 5
Sophie J. Bradley, University of Glasgow, UK
Short Talk: Targeting Muscarinic Receptors Rescues the Cognitive Deficit in Prion Neurodegenerative Disease in Mice

Wednesday, April 02 | 5:00PM - 7:00PM
Advances in Imaging Cellular Structure
This session is from Structural Biology
Room: Ballroom 1

Speaker 1 of 4
* Andrew B. Ward, The Scripps Research Institute, USA


Wednesday, April 02 | 5:00PM - 7:00PM
Advances in Imaging Cellular Structure
This session is from Structural Biology
Room: Ballroom 1

Speaker 2 of 4
Carolyn A. Larabell, University of California, San Francisco, USA
Correlated Fluorescence and X-Ray Tomography of Nuclear Organization and Chromatin Topology


Wednesday, April 02 | 5:00PM - 7:00PM
Advances in Imaging Cellular Structure
This session is from Structural Biology
Room: Ballroom 1

Speaker 3 of 4
John Briggs, European Molecular Biology Laboratory, Germany
Determining Structures in situ – Advances in Subtomogram Averaging and in Correlative Light/Electron Microscopy


Wednesday, April 02 | 5:00PM - 7:00PM
Advances in Imaging Cellular Structure
This session is from Structural Biology
Room: Ballroom 1

Speaker 4 of 4
Erik M. Jorgensen, University of Utah, USA
Flash-and-Freeze Electron Microscopy Reveals Dynamic Cellular Events


Wednesday, April 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch


Wednesday, April 02 | 7:30PM - 10:00PM
Poster Session 3
Room: Superior/Superior Lobby/Wasatch


Thursday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System

Room: Ballroom 2-3

Speaker 1 of 7
* Arthur Christopoulos, Monash University, Australia

Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System

Room: Ballroom 2-3

Speaker 2 of 7
Brigitte L. Kieffer, Douglas Institute, Canada
In vivo Signaling of Opioid Receptors

Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System

Room: Ballroom 2-3

Speaker 3 of 7
Sebastien Granier, Institut de Génomique Fonctionnelle, France
Opioid Receptor Structural Pharmacology

Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System

Room: Ballroom 2-3

Speaker 4 of 7
Fiona H. Marshall, Heptares Therapeutics Ltd., UK
Structure-Based Drug Discovery Applied to CNS GPCRs

Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System

Room: Ballroom 2-3

Speaker 5 of 7
Gustavo Fenalti, Celgene Corporation, USA
Short Talk: Molecular Control of Delta-Opioid Receptor Signaling

Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System

Room: Ballroom 2-3

Speaker 6 of 7
David M. Thal, Monash Institute of Pharmaceutical Sciences, Australia
Short Talk: Structural Studies of the M4 Muscarinic Acetylcholine Receptor

Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System

Room: Ballroom 2-3

Speaker 7 of 7
AJ Venkatakrishnan, Stanford University, USA
Short Talk: Decoupled Modules of Atomic Contacts Mediate Stability and Orchestrate Activation of GPCRs

Thursday, April 03 | 8:00AM - 11:00AM
Extending Structural Knowledge through Informatics and Model
ing
This session is from Structural Biology

Room: Ballroom 1

Speaker 1 of 6
* Ian A. Wilson, The Scripps Research Institute, USA


Thursday, April 03 | 8:00AM - 11:00AM
Extending Structural Knowledge through Informatics and Model
ing
This session is from Structural Biology

Room: Ballroom 1

Speaker 2 of 6
Peter D. Kwong, NIAID, National Institutes of Health, USA
Informatics and Structure in Vaccine Design


Thursday, April 03 | 8:00AM - 11:00AM
Extending Structural Knowledge through Informatics and Model
ing
This session is from Structural Biology

Room: Ballroom 1

Speaker 3 of 6
Jens Meiler, Vanderbilt University, USA
Modeling Membrane Proteins from Limited Experimental Data


Thursday, April 03 | 8:00AM - 11:00AM
Extending Structural Knowledge through Informatics and Model
ing
This session is from Structural Biology

Room: Ballroom 1

Speaker 4 of 6
Andrej Sali, University of California, San Francisco, USA
Integrative Structural Biology


Thursday, April 03 | 8:00AM - 11:00AM
Extending Structural Knowledge through Informatics and Model
ing
This session is from Structural Biology

Room: Ballroom 1

Speaker 5 of 6
Paul Robustelli, Columbia University, USA, USA
Short Talk: Tuning the Conformational Dynamics and Enzymatic Activity of Ribonuclease H


Thursday, April 03 | 8:00AM - 11:00AM
Extending Structural Knowledge through Informatics and Model
ing
This session is from Structural Biology

Room: Ballroom 1

Speaker 6 of 6
Julien R. C. Bergeron, King's College London, UK
Short Talk: Architecture and Assembly of the Type 3 Secretion System Basal Body


Thursday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Thursday, April 03 | 11:15AM - 5:00PM
On Own for Lunch and Recreation


Thursday, April 03 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, April 03 | 5:00PM - 6:15PM
Structure and Dynamics of GPCRs
Room: Ballroom 2

Speaker 1 of 3
* Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

Thursday, April 03 | 5:00PM - 6:15PM
Structure and Dynamics of GPCRs
Room: Ballroom 2

Speaker 2 of 3
Reinhard Grisshammer, NIH/NINDS, USA
Structure of the Agonist-Bound Neurotensin Receptor NTS1

Thursday, April 03 | 5:00PM - 6:15PM
Structure and Dynamics of GPCRs
Room: Ballroom 2

Speaker 3 of 3
Vsevolod Katritch, University of Southern California, USA
Structures of the Major Antithrombotic Target P2Y12R Provide Key Insights into Function and Pharmacology of Purinergic GPCRs

Thursday, April 03 | 5:00PM - 6:15PM
Applications of Computation and Design
This session is from Structural Biology
Room: Ballroom 1

Speaker 1 of 3
* Jens Meiler, Vanderbilt University, USA


Thursday, April 03 | 5:00PM - 6:15PM
Applications of Computation and Design
This session is from Structural Biology
Room: Ballroom 1

Speaker 2 of 3
William F. DeGrado, University of California, San Francisco, USA
Analysis and Design of Proton Transporters


Thursday, April 03 | 5:00PM - 6:15PM
Applications of Computation and Design
This session is from Structural Biology
Room: Ballroom 1

Speaker 3 of 3
Todd Yeates, University of California, Los Angeles, USA
Engineering Self-Assembling Protein Materials: Design Principles and Applications


Thursday, April 03 | 6:15PM - 7:15PM
Keynote Address (Joint)
Room: Ballroom 1-2

Speaker 1 of 1
Brian K. Kobilka, Stanford University School of Medicine, USA
Structural Insights into G Protein Coupled Receptor Signaling

Thursday, April 03 | 7:15PM - 7:30PM
Concluding Remarks (Joint)

Speaker 1 of 2
Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

Thursday, April 03 | 7:15PM - 7:30PM
Concluding Remarks (Joint)

Speaker 2 of 2
Andrew B. Ward, The Scripps Research Institute, USA

Thursday, April 03 | 7:30PM - 8:30PM
Social Hour
Room: Ballroom Lobby


Thursday, April 03 | 8:00PM - 9:00PM
Lite Bites
Room: Ballroom 2-3


Thursday, April 03 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2-3


Thursday, April 03 | 8:30PM - 11:00PM
Cash Bar
Room: Ballroom Lobby


Friday, April 04 | 10:25AM - 10:25AM
Departure


*Session Chair.