Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
AAA+ Proteins: From Atomic Structures to Organisms (2020A5)

Web Desc
Frontiers of Structural Biology joint with G Protein-Coupled Receptors: Structural Dynamics and Functional Implications Organizer(s): Andrew B. Ward and Wayne A. Hendrickson Date: March 30 - April 04, 2014 Location: Snowbird Resort, Snowbird, UT, USA Supported by the Directors' Fund For important information on the coronavirus, please click here Summary of Meeting: Direct observation of biological phenomena on a structural level provides a basis for understanding and manipulating molecular interactions within a cell and enabling endeavors such as structure-based drug design. The field of structural biology now operates on a scale from atoms to cells, and the most exciting research is being conducted at the interface of different technologies. Thus, it is important that practitioners of the various structural biology techniques come together and discuss a more holistic view of the field. The goal of this meeting is to connect leaders in the structural biology field, with particular emphasis on novel methods/technology development, highlights of complex cell biological insights made by pioneering structural efforts (across multiple biophysical disciplines) and contributions made by large-scale, high-throughput efforts. Additionally, because of the large amount of structural information that is becoming available (and will continue to do so), the meting highlights innovations made in areas of bioinformatics and modeling/design that have begun to harness the increasing structural information. Because this meeting brings together a diverse group of structural biologists who employ a variety of experimental techniques, the meeting should suppor the dissemination of cutting-edge advances and promote interaction among the vibrant international structural biology community. Scholarship Deadline: December 4 2013 Discounted Abstract Deadline: December 4 2013 Abstract Deadline: January 8 2014 Discounted Registration Deadline: January 30 2014 Abstacts when book is in proofing process We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Keio University School of Medicine We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We gratefully acknowledge the generous grant for this conference provided by: National Institute of General Medical Sciences (NIGMS) Grant No. 1R13GM109390-01 The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Frontiers of Structural Biology

joint with G Protein-Coupled Receptors: Structural Dynamics and Functional Implications

Organizer(s): Andrew B. Ward and Wayne A. Hendrickson

Date: March 30 - April 04, 2014
Location: Snowbird Resort, Snowbird, UT, USA

Supported by the Directors' Fund

For important information on the coronavirus, please click here

Summary of Meeting:

Direct observation of biological phenomena on a structural level provides a basis for understanding and manipulating molecular interactions within a cell and enabling endeavors such as structure-based drug design. The field of structural biology now operates on a scale from atoms to cells, and the most exciting research is being conducted at the interface of different technologies. Thus, it is important that practitioners of the various structural biology techniques come together and discuss a more holistic view of the field. The goal of this meeting is to connect leaders in the structural biology field, with particular emphasis on novel methods/technology development, highlights of complex cell biological insights made by pioneering structural efforts (across multiple biophysical disciplines) and contributions made by large-scale, high-throughput efforts. Additionally, because of the large amount of structural information that is becoming available (and will continue to do so), the meting highlights innovations made in areas of bioinformatics and modeling/design that have begun to harness the increasing structural information. Because this meeting brings together a diverse group of structural biologists who employ a variety of experimental techniques, the meeting should suppor the dissemination of cutting-edge advances and promote interaction among the vibrant international structural biology community.

Scholarship Deadline: December 4 2013

Discounted Abstract Deadline: December 4 2013

Abstract Deadline: January 8 2014

Discounted Registration Deadline: January 30 2014

Abstacts when book is in proofing process

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Keio University School of Medicine

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM109390-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, March 30 \| 4:00PM - 8:00PM Arrival and Registration Room: Golden Cliff
Sunday, March 30 \| 6:00PM - 8:00PM Welcome Mixer Room: Golden Cliff
Monday, March 31 \| 7:00AM - 8:00AM Breakfast Room: Golden Cliff/Eagles
Monday, March 31 \| 8:00AM - 8:10AM Opening Remarks (Joint) Room: Ballroom 1-3 Speaker 1 of 2 Christopher G. Tate, MRC Laboratory of Molecular Biology, UK
Monday, March 31 \| 8:00AM - 8:10AM Opening Remarks (Joint) Room: Ballroom 1-3 Speaker 2 of 2 Andrew B. Ward, The Scripps Research Institute, USA
Monday, March 31 \| 8:10AM - 9:10AM Keynote Address (Joint) Room: Ballroom 1-3 Speaker 1 of 3 * Christopher G. Tate, MRC Laboratory of Molecular Biology, UK
Monday, March 31 \| 8:10AM - 9:10AM Keynote Address (Joint) Room: Ballroom 1-3 Speaker 2 of 3 * Fiona H. Marshall, Heptares Therapeutics Ltd., UK
Monday, March 31 \| 8:10AM - 9:10AM Keynote Address (Joint) Room: Ballroom 1-3 Speaker 3 of 3 Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA Seven Transmembrane Receptors
Monday, March 31 \| 9:10AM - 12:30PM Cutting-Edge Biophysics to Study Membrane Protein Conformati onal Changes (Joint) Room: Ballroom 1-3 Speaker 1 of 6 * Reinhard Grisshammer, NIH/NINDS, USA
Monday, March 31 \| 9:10AM - 12:30PM Cutting-Edge Biophysics to Study Membrane Protein Conformati onal Changes (Joint) Room: Ballroom 1-3 Speaker 2 of 6 H. Eric Xu, Van Andel Institute, USA Toward a Structure of Rhodopsin-Arrestin Complex: Challenges in XFEL Data Processing and Structure Solution
Monday, March 31 \| 9:10AM - 12:30PM Cutting-Edge Biophysics to Study Membrane Protein Conformati onal Changes (Joint) Room: Ballroom 1-3 Speaker 3 of 6 Petra Fromme, Arizona State University, USA Femtosecond Nanocrystallography of Membrane Proteins
Monday, March 31 \| 9:10AM - 12:30PM Cutting-Edge Biophysics to Study Membrane Protein Conformati onal Changes (Joint) Room: Ballroom 1-3 Speaker 4 of 6 Wayne L. Hubbell, University of California, Los Angeles, USA Site-Directed Spin Labeling Strategies to Explore Conformational Dynamics of GPCRs
Monday, March 31 \| 9:10AM - 12:30PM Cutting-Edge Biophysics to Study Membrane Protein Conformati onal Changes (Joint) Room: Ballroom 1-3 Speaker 5 of 6 Ron O. Dror, Stanford University, USA Structural Basis for Allosteric Modulation of GPCRs
Monday, March 31 \| 9:10AM - 12:30PM Cutting-Edge Biophysics to Study Membrane Protein Conformati onal Changes (Joint) Room: Ballroom 1-3 Speaker 6 of 6 Martin J. Lohse, Max Delbrück Center for Molecular Medicine, Germany In vivo Studies of GPCR Conformational Changes Using Fluorescence-Based Assays
Monday, March 31 \| 9:40AM - 10:00AM Coffee Break Room: Ballroom Lobby
Monday, March 31 \| 12:30PM - 1:00PM Poster Setup Room: Superior/Superior Lobby/Wasatch
Monday, March 31 \| 12:30PM - 2:30PM On Own for Lunch and Recreation
Monday, March 31 \| 1:00PM - 10:00PM Poster Viewing Room: Superior/Superior Lobby/Wasatch
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Ballroom 1 Speaker 1 of 7 * Christopher P. Jaroniec, Ohio State University, USA
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Ballroom 1 Speaker 2 of 7 Andre A. S. T. Ribeiro, Columbia University, USA Determination of Signaling Pathways in Proteins Through Network Theory
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Ballroom 1 Speaker 3 of 7 Gydo van Zundert, Utrecht University, Netherlands Integrative Modeling of Biomolecular Complexes: HADDOCKing with Cryo-EM Data
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Ballroom 1 Speaker 4 of 7 Peter K. Kasson, University of Virginia, USA And Yet it Moves: Molecular Simulation Combined with Spectroscopic Methods to Probe Dynamic Function
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Ballroom 1 Speaker 5 of 7 Wyatt Strutz, NanoTemper Technologies, USA Some like it Hot: Determination of Biomolecular Interactions Using MicroScale Thermophoresis
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Ballroom 1 Speaker 6 of 7 Matteo Dal Peraro, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland Unveiling the Structure of Pathogenic Macromolecular Machines Using Integrative Dynamic Modeling
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1: Advances in Methodologies and Tools for Structur al Biology Room: Ballroom 1 Speaker 7 of 7 Yuba R. Bhandari, National Cancer Institute, USA Three-Dimensional Structure Determination of Large RNAs Using Small-Angle X-Ray Scattering
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 This session is from GPCRs Room: Ballroom 2-3 Speaker 1 of 9 * Fiona H. Marshall, Heptares Therapeutics Ltd., UK
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 This session is from GPCRs Room: Ballroom 2-3 Speaker 2 of 9 * Christopher G. Tate, MRC Laboratory of Molecular Biology, UK
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 This session is from GPCRs Room: Ballroom 2-3 Speaker 3 of 9 James H. Felce, University of Oxford, UK GPCR Family Structure - Explained by Receptor Organisation?
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 This session is from GPCRs Room: Ballroom 2-3 Speaker 4 of 9 Marta Filizola, Icahn School of Medicine at Mount Sinai, USA Associations between G Protein-Coupled Receptors in an Explicit Membrane Investigated by Massive Molecular Dynamics Simulations
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 This session is from GPCRs Room: Ballroom 2-3 Speaker 5 of 9 Kim C. Jonas, Imperial College London, UK Single Molecule Analysis of GPCR Transactivation via PD-PALM Reveals Oligomeric Complexes that Regulate Signal Sensitivity
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 This session is from GPCRs Room: Ballroom 2-3 Speaker 6 of 9 Christoph Klenk, University of Zurich, Switzerland A Generic System for Increased Expression and Stabilization of G Protein-Coupled Receptors by Directed Evolution
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 This session is from GPCRs Room: Ballroom 2-3 Speaker 7 of 9 Aashish Manglik, University of California, San Francisco, USA Leveraging Combinational Biology Methods to Understand GPCR Function
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 This session is from GPCRs Room: Ballroom 2-3 Speaker 8 of 9 Susmith Mukund, Genentech, USA Probing Mechanisms of Glucagon Receptor Inhibition by Antibodies
Monday, March 31 \| 2:30PM - 4:30PM Workshop 1 This session is from GPCRs Room: Ballroom 2-3 Speaker 9 of 9 Dimitrios Stamou, University of Copenhagen, Denmark Single-Molecule Conformational Dynamics and Direct Observation of Multiple GPCR Dimerization Interfaces
Monday, March 31 \| 4:30PM - 5:00PM Coffee Available Room: Ballroom Lobby
Monday, March 31 \| 5:00PM - 7:15PM Utilizing Next Generation Technologies for Structural Biolog y Room: Ballroom 1 Speaker 1 of 6 * Kurt Wüthrich, ETH Zürich, Switzerland
Monday, March 31 \| 5:00PM - 7:15PM Utilizing Next Generation Technologies for Structural Biolog y Room: Ballroom 1 Speaker 2 of 6 Aled M. Edwards, University of Toronto, Canada Structural Genomics in Aid of Drug Discovery
Monday, March 31 \| 5:00PM - 7:15PM Utilizing Next Generation Technologies for Structural Biolog y Room: Ballroom 1 Speaker 3 of 6 David P. Marciano, Stanford University, USA Short Talk: Rational Design of Novel PPARG Modulators with HDX
Monday, March 31 \| 5:00PM - 7:15PM Utilizing Next Generation Technologies for Structural Biolog y Room: Ballroom 1 Speaker 4 of 6 Ian A. Wilson, The Scripps Research Institute, USA Multidisciplinary Approaches for Tackling Challenging Problems in Human Health and Disease
Monday, March 31 \| 5:00PM - 7:15PM Utilizing Next Generation Technologies for Structural Biolog y Room: Ballroom 1 Speaker 5 of 6 Wayne A. Hendrickson, Columbia University, USA Diversity of Transmembrane Ion Channels Explored in a Structural Genomics Approach
Monday, March 31 \| 5:00PM - 7:15PM Utilizing Next Generation Technologies for Structural Biolog y Room: Ballroom 1 Speaker 6 of 6 Dmitry Lyumkis, The Salk Institute for Biological Studies, USA Short Talk: Direct Detectors and Single Particle Dissection of Conformational and Compositional Heterogeneity
Monday, March 31 \| 5:00PM - 7:15PM Family C and Frizzled GPCRs This session is from GPCRs Room: Ballroom 2-3 Speaker 1 of 5 * Brian K. Kobilka, Stanford University School of Medicine, USA
Monday, March 31 \| 5:00PM - 7:15PM Family C and Frizzled GPCRs This session is from GPCRs Room: Ballroom 2-3 Speaker 2 of 5 Jean-Philippe Pin, Montpellier University, France Structural Dynamics of Metabotropic Glutamate Receptors
Monday, March 31 \| 5:00PM - 7:15PM Family C and Frizzled GPCRs This session is from GPCRs Room: Ballroom 2-3 Speaker 3 of 5 Robert Lütjens, Addex Therapeutics, Switzerland Discovery of Allosteric Modulators of Metabotropic Glutamate Receptors
Monday, March 31 \| 5:00PM - 7:15PM Family C and Frizzled GPCRs This session is from GPCRs Room: Ballroom 2-3 Speaker 4 of 5 Gunnar Schulte, Karolinska Institutet, Sweden New Insights into Frizzled Signaling through Heterotrimeric G Proteins
Monday, March 31 \| 5:00PM - 7:15PM Family C and Frizzled GPCRs This session is from GPCRs Room: Ballroom 2-3 Speaker 5 of 5 Vadim Cherezov, The Scripps Research Institute, USA Structural Basis of Small Molecule Recognition by the Human Smoothened (Class Frizzled) 7TM
Monday, March 31 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Superior/Superior Lobby/Wasatch
Monday, March 31 \| 7:30PM - 10:00PM Poster Session 1 Room: Superior/Superior Lobby/Wasatch
Tuesday, April 01 \| 7:00AM - 8:00AM Breakfast Room: Golden Cliff/Eagles
Tuesday, April 01 \| 8:00AM - 11:00AM Structural and Functional Insights through the Use of Hybrid Methods Room: Ballroom 1 Speaker 1 of 5 * Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Tuesday, April 01 \| 8:00AM - 11:00AM Structural and Functional Insights through the Use of Hybrid Methods Room: Ballroom 1 Speaker 2 of 5 Gregory Alushin, NHLBI, National Institutes of Health, USA Hybrid Approaches to Define the Effect of GTP Hydrolysis and Taxol Binding on Microtubule Structure and Stability
Tuesday, April 01 \| 8:00AM - 11:00AM Structural and Functional Insights through the Use of Hybrid Methods Room: Ballroom 1 Speaker 3 of 5 Susan S. Taylor, University of California, San Diego, USA PKA: Assembly of Dynamic Isoform-Specific Macromolecular Signaling Complexes
Tuesday, April 01 \| 8:00AM - 11:00AM Structural and Functional Insights through the Use of Hybrid Methods Room: Ballroom 1 Speaker 4 of 5 Kurt Wüthrich, ETH Zürich, Switzerland Solution NMR Studies of GPCR Conformational Polymorphisms and Function-Related Rate Processes
Tuesday, April 01 \| 8:00AM - 11:00AM Structural and Functional Insights through the Use of Hybrid Methods Room: Ballroom 1 Speaker 5 of 5 Ponni Rajagopal, University of Washington, USA Short Talk: Hybrid Methodologies for Elucidating Structure and Function of a Chaperone
Tuesday, April 01 \| 8:00AM - 11:15AM Family B GPCRs This session is from GPCRs Room: Ballroom 2-3 Speaker 1 of 7 * Brigitte L. Kieffer, Douglas Institute, Canada
Tuesday, April 01 \| 8:00AM - 11:15AM Family B GPCRs This session is from GPCRs Room: Ballroom 2-3 Speaker 2 of 7 Kaspar Hollenstein, Heptares Therapeutics, UK Using Conformational Thermostabilization to Determine the Structures of Class B G Protein-Coupled Receptors
Tuesday, April 01 \| 8:00AM - 11:15AM Family B GPCRs This session is from GPCRs Room: Ballroom 2-3 Speaker 3 of 7 Patrick M. Sexton, Monash University, Australia GLP1 Receptor Signaling in Response to Peptides and Allosteric Modulators
Tuesday, April 01 \| 8:00AM - 11:15AM Family B GPCRs This session is from GPCRs Room: Ballroom 2-3 Speaker 4 of 7 Kathleen M. Caron, University of North Carolina at Chapel Hill, USA Role of RAMPs in Disease
Tuesday, April 01 \| 8:00AM - 11:15AM Family B GPCRs This session is from GPCRs Room: Ballroom 2-3 Speaker 5 of 7 Jean-Pierre Vilardaga, University of Pittsburgh, USA GPCR in Noncanonical Signaling Mode
Tuesday, April 01 \| 8:00AM - 11:15AM Family B GPCRs This session is from GPCRs Room: Ballroom 2-3 Speaker 6 of 7 Maria H. Hauge, Copenhagen University, Denmark Short Talk: Free Fatty Acid Receptor FFAR1/GPR40 - Combined Gq and Gs Signaling Mediates Hormone Secretion by Ago-Allosteric Super-Agonists
Tuesday, April 01 \| 8:00AM - 11:15AM Family B GPCRs This session is from GPCRs Room: Ballroom 2-3 Speaker 7 of 7 Minyoung Park, Novo Nordisk Research Center, USA Short Talk: Site-Specific Labeling on Ghrelin Receptor via Genetically-Encoded Unnatural Amino Acid
Tuesday, April 01 \| 9:20AM - 9:40AM Coffee Break Room: Ballroom Lobby
Tuesday, April 01 \| 11:00AM - 1:00PM Poster Setup Room: Superior/Superior Lobby/Wasatch
Tuesday, April 01 \| 11:00AM - 5:00PM On Own for Lunch and Recreation
Tuesday, April 01 \| 1:00PM - 10:00PM Poster Viewing Room: Superior/Superior Lobby/Wasatch
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 This session is from GPCRs Room: Ballroom 2-3 Speaker 1 of 9 * Fiona H. Marshall, Heptares Therapeutics Ltd., UK
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 This session is from GPCRs Room: Ballroom 2-3 Speaker 2 of 9 * Christopher G. Tate, MRC Laboratory of Molecular Biology, UK
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 This session is from GPCRs Room: Ballroom 2-3 Speaker 3 of 9 Benjamin R. Myers, University of Utah School of Medicine, USA Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the 7TM Oncoprotein Smoothened
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 This session is from GPCRs Room: Ballroom 2-3 Speaker 4 of 9 Tony Ngo, University of California, San Diego, USA N-Terminal Metalloprotease Processing Regulates Trafficking and Function of the Orphan G Protein-Coupled Receptor, GPR37L1
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 This session is from GPCRs Room: Ballroom 2-3 Speaker 5 of 9 Whitney M. Nolte, Pfizer, USA A Small Molecule Potentiator of Orthosteric Ligand Activity at the Glucagon-Like Peptide-1 Receptor Acts through Covalent Modification
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 This session is from GPCRs Room: Ballroom 2-3 Speaker 6 of 9 M. Flori Sassano, University of North Carolina, USA An Open-Source Platform for the Remarkably Facile Genome-Wide Interrogation of the Druggable GPCR-ome
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 This session is from GPCRs Room: Ballroom 2-3 Speaker 7 of 9 Silvia Sposini, Imperial College London, UK Post-Endocytic Sorting of the Luteinizing Hormone Receptor is Mediated by a Novel APPL1-Dependent Mechanism
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 This session is from GPCRs Room: Ballroom 2-3 Speaker 8 of 9 Amantha Thathiah, Catholic University of Leuven, Belgium GPCR Signaling Dysfunction in Alzheimer’s Disease
Tuesday, April 01 \| 2:30PM - 4:30PM Workshop 2 This session is from GPCRs Room: Ballroom 2-3 Speaker 9 of 9 Nagarajan Vaidehi, City of Hope National Medical Center, USA Insights into Thermostability of G-protein Coupled Receptors
Tuesday, April 01 \| 4:30PM - 5:00PM Coffee Available Room: Ballroom Lobby
Tuesday, April 01 \| 5:00PM - 7:00PM Structural Biology of Cellular Processes and Complexes Room: Ballroom 1 Speaker 1 of 5 * Susan S. Taylor, University of California, San Diego, USA
Tuesday, April 01 \| 5:00PM - 7:00PM Structural Biology of Cellular Processes and Complexes Room: Ballroom 1 Speaker 2 of 5 Christopher P. Jaroniec, Ohio State University, USA Structural and Dynamic Studies of Protein Assemblies by Solid State NMR Spectroscopy
Tuesday, April 01 \| 5:00PM - 7:00PM Structural Biology of Cellular Processes and Complexes Room: Ballroom 1 Speaker 3 of 5 Tatyana Polenova, University of Delaware, USA Structure and Dynamics of Microtubule-Associated and HIV-1 Protein Assemblies by MAS NMR Spectroscopy
Tuesday, April 01 \| 5:00PM - 7:00PM Structural Biology of Cellular Processes and Complexes Room: Ballroom 1 Speaker 4 of 5 Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA Structure-Function Studies of Cytosolic DNA Sensors Governing the Interferon Response
Tuesday, April 01 \| 5:00PM - 7:00PM Structural Biology of Cellular Processes and Complexes Room: Ballroom 1 Speaker 5 of 5 Nathan D. Thomsen, University of California, San Francisco, USA Short Talk: Reading between the Lines: Trapping Transient Protein Conformers for Structural Analysis, Functional Proteomics and Therapeutic Discovery
Tuesday, April 01 \| 5:00PM - 7:00PM New Insights into GPCR Signaling This session is from GPCRs Room: Ballroom 2-3 Speaker 1 of 5 * Roger K. Sunahara, University of California, San Diego, USA
Tuesday, April 01 \| 5:00PM - 7:00PM New Insights into GPCR Signaling This session is from GPCRs Room: Ballroom 2-3 Speaker 2 of 5 Arthur Christopoulos, Monash University, Australia Orthosteric and Allosteric Ligand Biased Signaling
Tuesday, April 01 \| 5:00PM - 7:00PM New Insights into GPCR Signaling This session is from GPCRs Room: Ballroom 2-3 Speaker 3 of 5 Vsevolod V. Gurevich, Vanderbilt University, USA Arrestin Shape-Shifting and Design of Signaling-Biased Mutants
Tuesday, April 01 \| 5:00PM - 7:00PM New Insights into GPCR Signaling This session is from GPCRs Room: Ballroom 2-3 Speaker 4 of 5 John J.G. Tesmer, University of Michigan, USA Structure and Small Molecule Inhibition of G Protein-Coupled Receptor Kinases
Tuesday, April 01 \| 5:00PM - 7:00PM New Insights into GPCR Signaling This session is from GPCRs Room: Ballroom 2-3 Speaker 5 of 5 Kamila M. Skieterska, Ghent University, Belgium Short Talk: Non-Degradative and Non-Lysine Mediated Ubiquitination of the Dopamine D4 Receptor
Tuesday, April 01 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Superior/Superior Lobby/Wasatch
Tuesday, April 01 \| 7:30PM - 10:00PM Poster Session 2 Room: Superior/Superior Lobby/Wasatch
Wednesday, April 02 \| 7:00AM - 8:00AM Breakfast Room: Golden Cliff/Eagles
Wednesday, April 02 \| 8:00AM - 11:00AM Advances in Membrane Protein Structure Solution Room: Ballroom 1 Speaker 1 of 6 * John Briggs, European Molecular Biology Laboratory, Germany
Wednesday, April 02 \| 8:00AM - 11:00AM Advances in Membrane Protein Structure Solution Room: Ballroom 1 Speaker 2 of 6 Liz Carpenter, University of Oxford, UK Structural Genomics of Human Membrane Proteins has Given Diverse Insights into ABC Transporter Function (ABCB10), Premature Aging (ZMPSTE24) and Channel Conformations (TREK-2)
Wednesday, April 02 \| 8:00AM - 11:00AM Advances in Membrane Protein Structure Solution Room: Ballroom 1 Speaker 3 of 6 Claus J. Loland, University of Copenhagen, Denmark Short Talk: Investigating Conformational Changes in a Neurotransmitter Transporter Homologue with Transition Metal-Ion FRET
Wednesday, April 02 \| 8:00AM - 11:00AM Advances in Membrane Protein Structure Solution Room: Ballroom 1 Speaker 4 of 6 Andrew B. Ward, The Scripps Research Institute, USA Structural Studies of Viral Envelope Proteins
Wednesday, April 02 \| 8:00AM - 11:00AM Advances in Membrane Protein Structure Solution Room: Ballroom 1 Speaker 5 of 6 Jennifer L. Johnson, Georgia Institute of Technology, USA Short Talk: The Development of Engineered Crystallization Chaperones to Promote Membrane Protein Crystallization
Wednesday, April 02 \| 8:00AM - 11:00AM Advances in Membrane Protein Structure Solution Room: Ballroom 1 Speaker 6 of 6 John Rubinstein, University of Toronto, Canada Electron Cryomicroscopy of Rotary ATPases
Wednesday, April 02 \| 8:00AM - 11:15AM Activation of GPCRs and G Proteins This session is from GPCRs Room: Ballroom 2-3 Speaker 1 of 7 * Martin J. Lohse, Max Delbrück Center for Molecular Medicine, Germany
Wednesday, April 02 \| 8:00AM - 11:15AM Activation of GPCRs and G Proteins This session is from GPCRs Room: Ballroom 2-3 Speaker 2 of 7 Mark von Zastrow, University of California, San Francisco, USA GPCR Signaling from Endosomes
Wednesday, April 02 \| 8:00AM - 11:15AM Activation of GPCRs and G Proteins This session is from GPCRs Room: Ballroom 2-3 Speaker 3 of 7 Andrew B. Tobin, University of Glasgow, Scotland Novel Animal Models to Define GPCR Therapeutic Potential
Wednesday, April 02 \| 8:00AM - 11:15AM Activation of GPCRs and G Proteins This session is from GPCRs Room: Ballroom 2-3 Speaker 4 of 7 Christopher G. Tate, MRC Laboratory of Molecular Biology, UK The Structural Basis for Ligand Efficacy in the Beta1-Adrenoceptor
Wednesday, April 02 \| 8:00AM - 11:15AM Activation of GPCRs and G Proteins This session is from GPCRs Room: Ballroom 2-3 Speaker 5 of 7 Roger K. Sunahara, University of California, San Diego, USA The Mechanism of G Protein Activation through Interactions with GPCRs and How Nucleotide Release from G Proteins in Turn Allosterically Modulates Ligand Binding at the Orthosteric Site
Wednesday, April 02 \| 8:00AM - 11:15AM Activation of GPCRs and G Proteins This session is from GPCRs Room: Ballroom 2-3 Speaker 6 of 7 Alexey Bondar, Institute of Nanobiology and Structural Biology, Czech Republic Short Talk: In vivo Imaging and Quantitation of Interactions between Gi/o Protein Subunits and GPCRs by Two-Photon Polarization Microscopy
Wednesday, April 02 \| 8:00AM - 11:15AM Activation of GPCRs and G Proteins This session is from GPCRs Room: Ballroom 2-3 Speaker 7 of 7 Susanne Nuber, University of Würzburg, Germany Short Talk: FRET Based beta-Arrestin2 Biosensors Reveal Receptor Specific Conformational Movements in Real Time and Living Cells
Wednesday, April 02 \| 9:20AM - 9:40AM Coffee Break Room: Ballroom Lobby
Wednesday, April 02 \| 11:00AM - 1:00PM Poster Setup Room: Superior/Superior Lobby/Wasatch
Wednesday, April 02 \| 11:00AM - 2:30PM On Own for Lunch and Recreation
Wednesday, April 02 \| 1:00PM - 10:00PM Poster Viewing Room: Superior/Superior Lobby/Wasatch
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 2: High-Throughput and Integrative Structural Biolo gy Room: Ballroom 1 Speaker 1 of 8 * Marc A. Elsliger, The Scripps Research Institute, USA The Joint Center for Structural Genomics – A PSI:Biology Center for High-Throughput Structure Determination
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 2: High-Throughput and Integrative Structural Biolo gy Room: Ballroom 1 Speaker 2 of 8 Kelly Kai Li Hew, Nanyang Technological University, Singapore Systems Structural Biology on Human Herpesviruses
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 2: High-Throughput and Integrative Structural Biolo gy Room: Ballroom 1 Speaker 3 of 8 Jürgen Haas, Swiss Institute of Bioinformatics, Switzerland The ProteinModelPortal - How Good Is My Prediction? –First Results from the Continuous Automated Model EvaluatiOn (CAMEO)
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 2: High-Throughput and Integrative Structural Biolo gy Room: Ballroom 1 Speaker 4 of 8 Allyn J. Schoeffler, Genentech, USA The Dynamics of cIAP1 Are Precisely Tuned for Rapid Activation
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 2: High-Throughput and Integrative Structural Biolo gy Room: Ballroom 1 Speaker 5 of 8 Ekaterina V. Filippova, Northwestern University, USA Functional and Structural Characterization of GNAT Family of Acetyltransferases
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 2: High-Throughput and Integrative Structural Biolo gy Room: Ballroom 1 Speaker 6 of 8 Jeong Hyun Lee, The Scripps Research Institute, USA Rapidly Uncovering New Epitopes on Viral Envelope Glycoproteins Using EM
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 2: High-Throughput and Integrative Structural Biolo gy Room: Ballroom 1 Speaker 7 of 8 Lenore Sparks, European Molecular Biology Laboratory, Germany Positioning the Nup214 Subcomplex and Nup358 into the Human Nuclear Pore Complex
Wednesday, April 02 \| 2:30PM - 4:30PM Workshop 2: High-Throughput and Integrative Structural Biolo gy Room: Ballroom 1 Speaker 8 of 8 Peter S. Lee, The Scripps Research Institute, USA Head Hunting: Targeting the Influenza Hemagglutinin Receptor Binding Site
Wednesday, April 02 \| 4:30PM - 5:00PM Coffee Available Room: Ballroom Lobby
Wednesday, April 02 \| 5:00PM - 7:00PM Advances in Imaging Cellular Structure Room: Ballroom 1 Speaker 1 of 4 * Andrew B. Ward, The Scripps Research Institute, USA
Wednesday, April 02 \| 5:00PM - 7:00PM Advances in Imaging Cellular Structure Room: Ballroom 1 Speaker 2 of 4 Carolyn A. Larabell, University of California, San Francisco, USA Correlated Fluorescence and X-Ray Tomography of Nuclear Organization and Chromatin Topology
Wednesday, April 02 \| 5:00PM - 7:00PM Advances in Imaging Cellular Structure Room: Ballroom 1 Speaker 3 of 4 John Briggs, European Molecular Biology Laboratory, Germany Determining Structures in situ – Advances in Subtomogram Averaging and in Correlative Light/Electron Microscopy
Wednesday, April 02 \| 5:00PM - 7:00PM Advances in Imaging Cellular Structure Room: Ballroom 1 Speaker 4 of 4 Erik M. Jorgensen, University of Utah, USA Flash-and-Freeze Electron Microscopy Reveals Dynamic Cellular Events
Wednesday, April 02 \| 5:00PM - 7:00PM Targeting GPCRs in Cancer and Inflammation This session is from GPCRs Room: Ballroom 2-3 Speaker 1 of 5 * Patrick M. Sexton, Monash University, Australia
Wednesday, April 02 \| 5:00PM - 7:00PM Targeting GPCRs in Cancer and Inflammation This session is from GPCRs Room: Ballroom 2-3 Speaker 2 of 5 Xavier J. Leroy, ITEOS Therapeutics, Belgium FPR2 Agonists in Inflammatory Disease
Wednesday, April 02 \| 5:00PM - 7:00PM Targeting GPCRs in Cancer and Inflammation This session is from GPCRs Room: Ballroom 2-3 Speaker 3 of 5 Michael Hanson, GPCR Consortium, USA S1P1 Receptor Structure and Ligand Analysis
Wednesday, April 02 \| 5:00PM - 7:00PM Targeting GPCRs in Cancer and Inflammation This session is from GPCRs Room: Ballroom 2-3 Speaker 4 of 5 Suzie Chen, Rutgers University, USA Metabotropic Glutamate Receptor Signaling in Cancer
Wednesday, April 02 \| 5:00PM - 7:00PM Targeting GPCRs in Cancer and Inflammation This session is from GPCRs Room: Ballroom 2-3 Speaker 5 of 5 Sophie J. Bradley, University of Glasgow, UK Short Talk: Targeting Muscarinic Receptors Rescues the Cognitive Deficit in Prion Neurodegenerative Disease in Mice
Wednesday, April 02 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Superior/Superior Lobby/Wasatch
Wednesday, April 02 \| 7:30PM - 10:00PM Poster Session 3 Room: Superior/Superior Lobby/Wasatch
Thursday, April 03 \| 7:00AM - 8:00AM Breakfast Room: Golden Cliff/Eagles
Thursday, April 03 \| 8:00AM - 11:00AM Extending Structural Knowledge through Informatics and Model ing Room: Ballroom 1 Speaker 1 of 6 * Ian A. Wilson, The Scripps Research Institute, USA
Thursday, April 03 \| 8:00AM - 11:00AM Extending Structural Knowledge through Informatics and Model ing Room: Ballroom 1 Speaker 2 of 6 Peter D. Kwong, NIAID, National Institutes of Health, USA Informatics and Structure in Vaccine Design
Thursday, April 03 \| 8:00AM - 11:00AM Extending Structural Knowledge through Informatics and Model ing Room: Ballroom 1 Speaker 3 of 6 Jens Meiler, Vanderbilt University, USA Modeling Membrane Proteins from Limited Experimental Data
Thursday, April 03 \| 8:00AM - 11:00AM Extending Structural Knowledge through Informatics and Model ing Room: Ballroom 1 Speaker 4 of 6 Andrej Sali, University of California, San Francisco, USA Integrative Structural Biology
Thursday, April 03 \| 8:00AM - 11:00AM Extending Structural Knowledge through Informatics and Model ing Room: Ballroom 1 Speaker 5 of 6 Paul Robustelli, Columbia University, USA, USA Short Talk: Tuning the Conformational Dynamics and Enzymatic Activity of Ribonuclease H
Thursday, April 03 \| 8:00AM - 11:00AM Extending Structural Knowledge through Informatics and Model ing Room: Ballroom 1 Speaker 6 of 6 Julien R. C. Bergeron, King's College London, UK Short Talk: Architecture and Assembly of the Type 3 Secretion System Basal Body
Thursday, April 03 \| 8:00AM - 11:15AM Targeting GPCRs Involved in the Treatment of Diseases of the Central Nervous System This session is from GPCRs Room: Ballroom 2-3 Speaker 1 of 7 * Arthur Christopoulos, Monash University, Australia
Thursday, April 03 \| 8:00AM - 11:15AM Targeting GPCRs Involved in the Treatment of Diseases of the Central Nervous System This session is from GPCRs Room: Ballroom 2-3 Speaker 2 of 7 Brigitte L. Kieffer, Douglas Institute, Canada In vivo Signaling of Opioid Receptors
Thursday, April 03 \| 8:00AM - 11:15AM Targeting GPCRs Involved in the Treatment of Diseases of the Central Nervous System This session is from GPCRs Room: Ballroom 2-3 Speaker 3 of 7 Sebastien Granier, Institut de Génomique Fonctionnelle, France Opioid Receptor Structural Pharmacology
Thursday, April 03 \| 8:00AM - 11:15AM Targeting GPCRs Involved in the Treatment of Diseases of the Central Nervous System This session is from GPCRs Room: Ballroom 2-3 Speaker 4 of 7 Fiona H. Marshall, Heptares Therapeutics Ltd., UK Structure-Based Drug Discovery Applied to CNS GPCRs
Thursday, April 03 \| 8:00AM - 11:15AM Targeting GPCRs Involved in the Treatment of Diseases of the Central Nervous System This session is from GPCRs Room: Ballroom 2-3 Speaker 5 of 7 Gustavo Fenalti, Celgene Corporation, USA Short Talk: Molecular Control of Delta-Opioid Receptor Signaling
Thursday, April 03 \| 8:00AM - 11:15AM Targeting GPCRs Involved in the Treatment of Diseases of the Central Nervous System This session is from GPCRs Room: Ballroom 2-3 Speaker 6 of 7 David M. Thal, Monash Institute of Pharmaceutical Sciences, Australia Short Talk: Structural Studies of the M4 Muscarinic Acetylcholine Receptor
Thursday, April 03 \| 8:00AM - 11:15AM Targeting GPCRs Involved in the Treatment of Diseases of the Central Nervous System This session is from GPCRs Room: Ballroom 2-3 Speaker 7 of 7 AJ Venkatakrishnan, Stanford University, USA Short Talk: Decoupled Modules of Atomic Contacts Mediate Stability and Orchestrate Activation of GPCRs
Thursday, April 03 \| 9:20AM - 9:40AM Coffee Break Room: Ballroom Lobby
Thursday, April 03 \| 11:00AM - 5:00PM On Own for Lunch and Recreation
Thursday, April 03 \| 4:30PM - 5:00PM Coffee Available Room: Ballroom Lobby
Thursday, April 03 \| 5:00PM - 6:15PM Applications of Computation and Design Room: Ballroom 1 Speaker 1 of 3 * Jens Meiler, Vanderbilt University, USA
Thursday, April 03 \| 5:00PM - 6:15PM Applications of Computation and Design Room: Ballroom 1 Speaker 2 of 3 William F. DeGrado, University of California, San Francisco, USA Analysis and Design of Proton Transporters
Thursday, April 03 \| 5:00PM - 6:15PM Applications of Computation and Design Room: Ballroom 1 Speaker 3 of 3 Todd Yeates, University of California, Los Angeles, USA Engineering Self-Assembling Protein Materials: Design Principles and Applications
Thursday, April 03 \| 5:00PM - 6:15PM Structure and Dynamics of GPCRs This session is from GPCRs Room: Ballroom 2 Speaker 1 of 3 * Christopher G. Tate, MRC Laboratory of Molecular Biology, UK
Thursday, April 03 \| 5:00PM - 6:15PM Structure and Dynamics of GPCRs This session is from GPCRs Room: Ballroom 2 Speaker 2 of 3 Reinhard Grisshammer, NIH/NINDS, USA Structure of the Agonist-Bound Neurotensin Receptor NTS1
Thursday, April 03 \| 5:00PM - 6:15PM Structure and Dynamics of GPCRs This session is from GPCRs Room: Ballroom 2 Speaker 3 of 3 Vsevolod Katritch, University of Southern California, USA Structures of the Major Antithrombotic Target P2Y12R Provide Key Insights into Function and Pharmacology of Purinergic GPCRs
Thursday, April 03 \| 6:15PM - 7:15PM Keynote Address (Joint) Room: Ballroom 1-2 Speaker 1 of 1 Brian K. Kobilka, Stanford University School of Medicine, USA Structural Insights into G Protein Coupled Receptor Signaling
Thursday, April 03 \| 7:15PM - 7:30PM Concluding Remarks (Joint) Speaker 1 of 2 Christopher G. Tate, MRC Laboratory of Molecular Biology, UK
Thursday, April 03 \| 7:15PM - 7:30PM Concluding Remarks (Joint) Speaker 2 of 2 Andrew B. Ward, The Scripps Research Institute, USA
Thursday, April 03 \| 7:30PM - 8:30PM Social Hour Room: Ballroom Lobby
Thursday, April 03 \| 8:00PM - 9:00PM Lite Bites Room: Ballroom 2-3
Thursday, April 03 \| 8:00PM - 11:00PM Entertainment Room: Ballroom 2-3
Thursday, April 03 \| 8:30PM - 11:00PM Cash Bar Room: Ballroom Lobby
Friday, April 04 \| 10:23AM - 10:23AM Departure *Session Chair †Invited, not yet responded.