Web Desc
Frontiers of Structural Biology
joint with G Protein-Coupled Receptors: Structural Dynamics and Functional Implications
Organizer(s): Andrew B. Ward and Wayne A. Hendrickson
Date: March 30 - April 04, 2014
Location: Snowbird Resort, Snowbird, UT, USA
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Direct observation of biological phenomena on a structural level provides a basis for understanding and manipulating molecular interactions within a cell and enabling endeavors such as structure-based drug design. The field of structural biology now operates on a scale from atoms to cells, and the most exciting research is being conducted at the interface of different technologies. Thus, it is important that practitioners of the various structural biology techniques come together and discuss a more holistic view of the field. The goal of this meeting is to connect leaders in the structural biology field, with particular emphasis on novel methods/technology development, highlights of complex cell biological insights made by pioneering structural efforts (across multiple biophysical disciplines) and contributions made by large-scale, high-throughput efforts. Additionally, because of the large amount of structural information that is becoming available (and will continue to do so), the meting highlights innovations made in areas of bioinformatics and modeling/design that have begun to harness the increasing structural information. Because this meeting brings together a diverse group of structural biologists who employ a variety of experimental techniques, the meeting should suppor the dissemination of cutting-edge advances and promote interaction among the vibrant international structural biology community.
Scholarship Deadline: December 4 2013
Discounted Abstract Deadline: December 4 2013
Abstract Deadline: January 8 2014
Discounted Registration Deadline: January 30 2014
Abstacts when book is in proofing process


We gratefully acknowledge additional support for this conference from:
Bruker CorporationFEI CompanyISOTEC, a member of the Sigma-Aldrich GroupNew Era Enterprises, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Keio University School of Medicine
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
S. Karger AG - Cells Tissues Organs
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM109390-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 30 | 4:00PM - 8:00PM
Arrival and Registration
Room: Golden Cliff


Sunday, March 30 | 6:00PM - 8:00PM
Welcome Mixer
Room: Golden Cliff


Monday, March 31 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, March 31 | 8:00AM - 8:10AM
Opening Remarks (Joint)
Room: Ballroom 1-3

Speaker 1 of 2
Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

Monday, March 31 | 8:00AM - 8:10AM
Opening Remarks (Joint)
Room: Ballroom 1-3

Speaker 2 of 2
Andrew B. Ward, The Scripps Research Institute, USA

Monday, March 31 | 8:10AM - 9:10AM
Keynote Address (Joint)
Room: Ballroom 1-3

Speaker 1 of 3
* Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

Monday, March 31 | 8:10AM - 9:10AM
Keynote Address (Joint)
Room: Ballroom 1-3

Speaker 2 of 3
* Fiona H. Marshall, Heptares Therapeutics Ltd., UK

Monday, March 31 | 8:10AM - 9:10AM
Keynote Address (Joint)
Room: Ballroom 1-3

Speaker 3 of 3
Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA
Seven Transmembrane Receptors

Monday, March 31 | 9:10AM - 12:30PM
Cutting-Edge Biophysics to Study Membrane Protein Conformati
onal Changes (Joint)

Room: Ballroom 1-3

Speaker 1 of 6
* Reinhard Grisshammer, NIH/NINDS, USA

Monday, March 31 | 9:10AM - 12:30PM
Cutting-Edge Biophysics to Study Membrane Protein Conformati
onal Changes (Joint)

Room: Ballroom 1-3

Speaker 2 of 6
H. Eric Xu, Van Andel Institute, USA
Toward a Structure of Rhodopsin-Arrestin Complex: Challenges in XFEL Data Processing and Structure Solution

Monday, March 31 | 9:10AM - 12:30PM
Cutting-Edge Biophysics to Study Membrane Protein Conformati
onal Changes (Joint)

Room: Ballroom 1-3

Speaker 3 of 6
Petra Fromme, Arizona State University, USA
Femtosecond Nanocrystallography of Membrane Proteins

Monday, March 31 | 9:10AM - 12:30PM
Cutting-Edge Biophysics to Study Membrane Protein Conformati
onal Changes (Joint)

Room: Ballroom 1-3

Speaker 4 of 6
Wayne L. Hubbell, University of California, Los Angeles, USA
Site-Directed Spin Labeling Strategies to Explore Conformational Dynamics of GPCRs

Monday, March 31 | 9:10AM - 12:30PM
Cutting-Edge Biophysics to Study Membrane Protein Conformati
onal Changes (Joint)

Room: Ballroom 1-3

Speaker 5 of 6
Ron O. Dror, Stanford University, USA
Structural Basis for Allosteric Modulation of GPCRs

Monday, March 31 | 9:10AM - 12:30PM
Cutting-Edge Biophysics to Study Membrane Protein Conformati
onal Changes (Joint)

Room: Ballroom 1-3

Speaker 6 of 6
Martin J. Lohse, Max Delbrück Center for Molecular Medicine, Germany
In vivo Studies of GPCR Conformational Changes Using Fluorescence-Based Assays

Monday, March 31 | 9:40AM - 10:00AM
Coffee Break
Room: Ballroom Lobby


Monday, March 31 | 12:30PM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Monday, March 31 | 12:30PM - 2:30PM
On Own for Lunch and Recreation


Monday, March 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Ballroom 1

Speaker 1 of 7
* Christopher P. Jaroniec, Ohio State University, USA

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Ballroom 1

Speaker 2 of 7
Andre A. S. T. Ribeiro, Columbia University, USA
Determination of Signaling Pathways in Proteins Through Network Theory

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Ballroom 1

Speaker 3 of 7
Gydo van Zundert, Utrecht University, Netherlands
Integrative Modeling of Biomolecular Complexes: HADDOCKing with Cryo-EM Data

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Ballroom 1

Speaker 4 of 7
Peter K. Kasson, University of Virginia, USA
And Yet it Moves: Molecular Simulation Combined with Spectroscopic Methods to Probe Dynamic Function

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Ballroom 1

Speaker 5 of 7
Wyatt Strutz, NanoTemper Technologies, USA
Some like it Hot: Determination of Biomolecular Interactions Using MicroScale Thermophoresis

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Ballroom 1

Speaker 6 of 7
Matteo Dal Peraro, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Unveiling the Structure of Pathogenic Macromolecular Machines Using Integrative Dynamic Modeling

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1: Advances in Methodologies and Tools for Structur
al Biology
Room: Ballroom 1

Speaker 7 of 7
Yuba R. Bhandari, National Cancer Institute, USA
Three-Dimensional Structure Determination of Large RNAs Using Small-Angle X-Ray Scattering

Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
This session is from GPCRs
Room: Ballroom 2-3

Speaker 1 of 9
* Fiona H. Marshall, Heptares Therapeutics Ltd., UK


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
This session is from GPCRs
Room: Ballroom 2-3

Speaker 2 of 9
* Christopher G. Tate, MRC Laboratory of Molecular Biology, UK


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
This session is from GPCRs
Room: Ballroom 2-3

Speaker 3 of 9
James H. Felce, University of Oxford, UK
GPCR Family Structure - Explained by Receptor Organisation?


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
This session is from GPCRs
Room: Ballroom 2-3

Speaker 4 of 9
Marta Filizola, Icahn School of Medicine at Mount Sinai, USA
Associations between G Protein-Coupled Receptors in an Explicit Membrane Investigated by Massive Molecular Dynamics Simulations


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
This session is from GPCRs
Room: Ballroom 2-3

Speaker 5 of 9
Kim C. Jonas, Imperial College London, UK
Single Molecule Analysis of GPCR Transactivation via PD-PALM Reveals Oligomeric Complexes that Regulate Signal Sensitivity


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
This session is from GPCRs
Room: Ballroom 2-3

Speaker 6 of 9
Christoph Klenk, University of Zurich, Switzerland
A Generic System for Increased Expression and Stabilization of G Protein-Coupled Receptors by Directed Evolution


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
This session is from GPCRs
Room: Ballroom 2-3

Speaker 7 of 9
Aashish Manglik, University of California, San Francisco, USA
Leveraging Combinational Biology Methods to Understand GPCR Function


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
This session is from GPCRs
Room: Ballroom 2-3

Speaker 8 of 9
Susmith Mukund, Genentech, USA
Probing Mechanisms of Glucagon Receptor Inhibition by Antibodies


Monday, March 31 | 2:30PM - 4:30PM
Workshop 1
This session is from GPCRs
Room: Ballroom 2-3

Speaker 9 of 9
Dimitrios Stamou, University of Copenhagen, Denmark
Single-Molecule Conformational Dynamics and Direct Observation of Multiple GPCR Dimerization Interfaces


Monday, March 31 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, March 31 | 5:00PM - 7:15PM
Utilizing Next Generation Technologies for Structural Biolog
y

Room: Ballroom 1

Speaker 1 of 6
* Kurt Wüthrich, ETH Zürich, Switzerland

Monday, March 31 | 5:00PM - 7:15PM
Utilizing Next Generation Technologies for Structural Biolog
y

Room: Ballroom 1

Speaker 2 of 6
Aled M. Edwards, University of Toronto, Canada
Structural Genomics in Aid of Drug Discovery

Monday, March 31 | 5:00PM - 7:15PM
Utilizing Next Generation Technologies for Structural Biolog
y

Room: Ballroom 1

Speaker 3 of 6
David P. Marciano, Stanford University, USA
Short Talk: Rational Design of Novel PPARG Modulators with HDX

Monday, March 31 | 5:00PM - 7:15PM
Utilizing Next Generation Technologies for Structural Biolog
y

Room: Ballroom 1

Speaker 4 of 6
Ian A. Wilson, The Scripps Research Institute, USA
Multidisciplinary Approaches for Tackling Challenging Problems in Human Health and Disease

Monday, March 31 | 5:00PM - 7:15PM
Utilizing Next Generation Technologies for Structural Biolog
y

Room: Ballroom 1

Speaker 5 of 6
Wayne A. Hendrickson, Columbia University, USA
Diversity of Transmembrane Ion Channels Explored in a Structural Genomics Approach

Monday, March 31 | 5:00PM - 7:15PM
Utilizing Next Generation Technologies for Structural Biolog
y

Room: Ballroom 1

Speaker 6 of 6
Dmitry Lyumkis, The Salk Institute for Biological Studies, USA
Short Talk: Direct Detectors and Single Particle Dissection of Conformational and Compositional Heterogeneity

Monday, March 31 | 5:00PM - 7:15PM
Family C and Frizzled GPCRs
This session is from GPCRs
Room: Ballroom 2-3

Speaker 1 of 5
* Brian K. Kobilka, Stanford University School of Medicine, USA


Monday, March 31 | 5:00PM - 7:15PM
Family C and Frizzled GPCRs
This session is from GPCRs
Room: Ballroom 2-3

Speaker 2 of 5
Jean-Philippe Pin, Montpellier University, France
Structural Dynamics of Metabotropic Glutamate Receptors


Monday, March 31 | 5:00PM - 7:15PM
Family C and Frizzled GPCRs
This session is from GPCRs
Room: Ballroom 2-3

Speaker 3 of 5
Robert Lütjens, Addex Therapeutics, Switzerland
Discovery of Allosteric Modulators of Metabotropic Glutamate Receptors


Monday, March 31 | 5:00PM - 7:15PM
Family C and Frizzled GPCRs
This session is from GPCRs
Room: Ballroom 2-3

Speaker 4 of 5
Gunnar Schulte, Karolinska Institutet, Sweden
New Insights into Frizzled Signaling through Heterotrimeric G Proteins


Monday, March 31 | 5:00PM - 7:15PM
Family C and Frizzled GPCRs
This session is from GPCRs
Room: Ballroom 2-3

Speaker 5 of 5
Vadim Cherezov, The Scripps Research Institute, USA
Structural Basis of Small Molecule Recognition by the Human Smoothened (Class Frizzled) 7TM


Monday, March 31 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch


Monday, March 31 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby/Wasatch


Tuesday, April 01 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, April 01 | 8:00AM - 11:00AM
Structural and Functional Insights through the Use of Hybrid
Methods

Room: Ballroom 1

Speaker 1 of 5
* Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA

Tuesday, April 01 | 8:00AM - 11:00AM
Structural and Functional Insights through the Use of Hybrid
Methods

Room: Ballroom 1

Speaker 2 of 5
Gregory Alushin, NHLBI, National Institutes of Health, USA
Hybrid Approaches to Define the Effect of GTP Hydrolysis and Taxol Binding on Microtubule Structure and Stability

Tuesday, April 01 | 8:00AM - 11:00AM
Structural and Functional Insights through the Use of Hybrid
Methods

Room: Ballroom 1

Speaker 3 of 5
Susan S. Taylor, University of California, San Diego, USA
PKA: Assembly of Dynamic Isoform-Specific Macromolecular Signaling Complexes

Tuesday, April 01 | 8:00AM - 11:00AM
Structural and Functional Insights through the Use of Hybrid
Methods

Room: Ballroom 1

Speaker 4 of 5
Kurt Wüthrich, ETH Zürich, Switzerland
Solution NMR Studies of GPCR Conformational Polymorphisms and Function-Related Rate Processes

Tuesday, April 01 | 8:00AM - 11:00AM
Structural and Functional Insights through the Use of Hybrid
Methods

Room: Ballroom 1

Speaker 5 of 5
Ponni Rajagopal, University of Washington, USA
Short Talk: Hybrid Methodologies for Elucidating Structure and Function of a Chaperone

Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
This session is from GPCRs
Room: Ballroom 2-3

Speaker 1 of 7
* Brigitte L. Kieffer, Douglas Institute, Canada


Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
This session is from GPCRs
Room: Ballroom 2-3

Speaker 2 of 7
Kaspar Hollenstein, Heptares Therapeutics, UK
Using Conformational Thermostabilization to Determine the Structures of Class B G Protein-Coupled Receptors


Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
This session is from GPCRs
Room: Ballroom 2-3

Speaker 3 of 7
Patrick M. Sexton, Monash University, Australia
GLP1 Receptor Signaling in Response to Peptides and Allosteric Modulators


Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
This session is from GPCRs
Room: Ballroom 2-3

Speaker 4 of 7
Kathleen M. Caron, University of North Carolina at Chapel Hill, USA
Role of RAMPs in Disease


Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
This session is from GPCRs
Room: Ballroom 2-3

Speaker 5 of 7
Jean-Pierre Vilardaga, University of Pittsburgh, USA
GPCR in Noncanonical Signaling Mode


Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
This session is from GPCRs
Room: Ballroom 2-3

Speaker 6 of 7
Maria H. Hauge, Copenhagen University, Denmark
Short Talk: Free Fatty Acid Receptor FFAR1/GPR40 - Combined Gq and Gs Signaling Mediates Hormone Secretion by Ago-Allosteric Super-Agonists


Tuesday, April 01 | 8:00AM - 11:15AM
Family B GPCRs
This session is from GPCRs
Room: Ballroom 2-3

Speaker 7 of 7
Minyoung Park, Novo Nordisk Research Center, USA
Short Talk: Site-Specific Labeling on Ghrelin Receptor via Genetically-Encoded Unnatural Amino Acid


Tuesday, April 01 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Tuesday, April 01 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Tuesday, April 01 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Tuesday, April 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
This session is from GPCRs
Room: Ballroom 2-3

Speaker 1 of 9
* Fiona H. Marshall, Heptares Therapeutics Ltd., UK


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
This session is from GPCRs
Room: Ballroom 2-3

Speaker 2 of 9
* Christopher G. Tate, MRC Laboratory of Molecular Biology, UK


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
This session is from GPCRs
Room: Ballroom 2-3

Speaker 3 of 9
Benjamin R. Myers, University of Utah School of Medicine, USA
Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the 7TM Oncoprotein Smoothened


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
This session is from GPCRs
Room: Ballroom 2-3

Speaker 4 of 9
Tony Ngo, University of California, San Diego, USA
N-Terminal Metalloprotease Processing Regulates Trafficking and Function of the Orphan G Protein-Coupled Receptor, GPR37L1


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
This session is from GPCRs
Room: Ballroom 2-3

Speaker 5 of 9
Whitney M. Nolte, Pfizer, USA
A Small Molecule Potentiator of Orthosteric Ligand Activity at the Glucagon-Like Peptide-1 Receptor Acts through Covalent Modification


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
This session is from GPCRs
Room: Ballroom 2-3

Speaker 6 of 9
M. Flori Sassano, University of North Carolina, USA
An Open-Source Platform for the Remarkably Facile Genome-Wide Interrogation of the Druggable GPCR-ome


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
This session is from GPCRs
Room: Ballroom 2-3

Speaker 7 of 9
Silvia Sposini, Imperial College London, UK
Post-Endocytic Sorting of the Luteinizing Hormone Receptor is Mediated by a Novel APPL1-Dependent Mechanism


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
This session is from GPCRs
Room: Ballroom 2-3

Speaker 8 of 9
Amantha Thathiah, Catholic University of Leuven, Belgium
GPCR Signaling Dysfunction in Alzheimer’s Disease


Tuesday, April 01 | 2:30PM - 4:30PM
Workshop 2
This session is from GPCRs
Room: Ballroom 2-3

Speaker 9 of 9
Nagarajan Vaidehi, City of Hope National Medical Center, USA
Insights into Thermostability of G-protein Coupled Receptors


Tuesday, April 01 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, April 01 | 5:00PM - 7:00PM
Structural Biology of Cellular Processes and Complexes
Room: Ballroom 1

Speaker 1 of 5
* Susan S. Taylor, University of California, San Diego, USA

Tuesday, April 01 | 5:00PM - 7:00PM
Structural Biology of Cellular Processes and Complexes
Room: Ballroom 1

Speaker 2 of 5
Christopher P. Jaroniec, Ohio State University, USA
Structural and Dynamic Studies of Protein Assemblies by Solid State NMR Spectroscopy

Tuesday, April 01 | 5:00PM - 7:00PM
Structural Biology of Cellular Processes and Complexes
Room: Ballroom 1

Speaker 3 of 5
Tatyana Polenova, University of Delaware, USA
Structure and Dynamics of Microtubule-Associated and HIV-1 Protein Assemblies by MAS NMR Spectroscopy

Tuesday, April 01 | 5:00PM - 7:00PM
Structural Biology of Cellular Processes and Complexes
Room: Ballroom 1

Speaker 4 of 5
Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Structure-Function Studies of Cytosolic DNA Sensors Governing the Interferon Response

Tuesday, April 01 | 5:00PM - 7:00PM
Structural Biology of Cellular Processes and Complexes
Room: Ballroom 1

Speaker 5 of 5
Nathan D. Thomsen, University of California, San Francisco, USA
Short Talk: Reading between the Lines: Trapping Transient Protein Conformers for Structural Analysis, Functional Proteomics and Therapeutic Discovery

Tuesday, April 01 | 5:00PM - 7:00PM
New Insights into GPCR Signaling
This session is from GPCRs
Room: Ballroom 2-3

Speaker 1 of 5
* Roger K. Sunahara, University of California, San Diego, USA


Tuesday, April 01 | 5:00PM - 7:00PM
New Insights into GPCR Signaling
This session is from GPCRs
Room: Ballroom 2-3

Speaker 2 of 5
Arthur Christopoulos, Monash University, Australia
Orthosteric and Allosteric Ligand Biased Signaling


Tuesday, April 01 | 5:00PM - 7:00PM
New Insights into GPCR Signaling
This session is from GPCRs
Room: Ballroom 2-3

Speaker 3 of 5
Vsevolod V. Gurevich, Vanderbilt University, USA
Arrestin Shape-Shifting and Design of Signaling-Biased Mutants


Tuesday, April 01 | 5:00PM - 7:00PM
New Insights into GPCR Signaling
This session is from GPCRs
Room: Ballroom 2-3

Speaker 4 of 5
John J.G. Tesmer, University of Michigan, USA
Structure and Small Molecule Inhibition of G Protein-Coupled Receptor Kinases


Tuesday, April 01 | 5:00PM - 7:00PM
New Insights into GPCR Signaling
This session is from GPCRs
Room: Ballroom 2-3

Speaker 5 of 5
Kamila M. Skieterska, Ghent University, Belgium
Short Talk: Non-Degradative and Non-Lysine Mediated Ubiquitination of the Dopamine D4 Receptor


Tuesday, April 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch


Tuesday, April 01 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby/Wasatch


Wednesday, April 02 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, April 02 | 8:00AM - 11:00AM
Advances in Membrane Protein Structure Solution
Room: Ballroom 1

Speaker 1 of 6
* John Briggs, European Molecular Biology Laboratory, Germany

Wednesday, April 02 | 8:00AM - 11:00AM
Advances in Membrane Protein Structure Solution
Room: Ballroom 1

Speaker 2 of 6
Liz Carpenter, University of Oxford, UK
Structural Genomics of Human Membrane Proteins has Given Diverse Insights into ABC Transporter Function (ABCB10), Premature Aging (ZMPSTE24) and Channel Conformations (TREK-2)

Wednesday, April 02 | 8:00AM - 11:00AM
Advances in Membrane Protein Structure Solution
Room: Ballroom 1

Speaker 3 of 6
Claus J. Loland, University of Copenhagen, Denmark
Short Talk: Investigating Conformational Changes in a Neurotransmitter Transporter Homologue with Transition Metal-Ion FRET

Wednesday, April 02 | 8:00AM - 11:00AM
Advances in Membrane Protein Structure Solution
Room: Ballroom 1

Speaker 4 of 6
Andrew B. Ward, The Scripps Research Institute, USA
Structural Studies of Viral Envelope Proteins

Wednesday, April 02 | 8:00AM - 11:00AM
Advances in Membrane Protein Structure Solution
Room: Ballroom 1

Speaker 5 of 6
Jennifer L. Johnson, Georgia Institute of Technology, USA
Short Talk: The Development of Engineered Crystallization Chaperones to Promote Membrane Protein Crystallization

Wednesday, April 02 | 8:00AM - 11:00AM
Advances in Membrane Protein Structure Solution
Room: Ballroom 1

Speaker 6 of 6
John Rubinstein, University of Toronto, Canada
Electron Cryomicroscopy of Rotary ATPases

Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
This session is from GPCRs
Room: Ballroom 2-3

Speaker 1 of 7
* Martin J. Lohse, Max Delbrück Center for Molecular Medicine, Germany


Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
This session is from GPCRs
Room: Ballroom 2-3

Speaker 2 of 7
Mark von Zastrow, University of California, San Francisco, USA
GPCR Signaling from Endosomes


Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
This session is from GPCRs
Room: Ballroom 2-3

Speaker 3 of 7
Andrew B. Tobin, University of Glasgow, Scotland
Novel Animal Models to Define GPCR Therapeutic Potential


Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
This session is from GPCRs
Room: Ballroom 2-3

Speaker 4 of 7
Christopher G. Tate, MRC Laboratory of Molecular Biology, UK
The Structural Basis for Ligand Efficacy in the Beta1-Adrenoceptor


Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
This session is from GPCRs
Room: Ballroom 2-3

Speaker 5 of 7
Roger K. Sunahara, University of California, San Diego, USA
The Mechanism of G Protein Activation through Interactions with GPCRs and How Nucleotide Release from G Proteins in Turn Allosterically Modulates Ligand Binding at the Orthosteric Site


Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
This session is from GPCRs
Room: Ballroom 2-3

Speaker 6 of 7
Alexey Bondar, Institute of Nanobiology and Structural Biology, Czech Republic
Short Talk: In vivo Imaging and Quantitation of Interactions between Gi/o Protein Subunits and GPCRs by Two-Photon Polarization Microscopy


Wednesday, April 02 | 8:00AM - 11:15AM
Activation of GPCRs and G Proteins
This session is from GPCRs
Room: Ballroom 2-3

Speaker 7 of 7
Susanne Nuber, University of Würzburg, Germany
Short Talk: FRET Based beta-Arrestin2 Biosensors Reveal Receptor Specific Conformational Movements in Real Time and Living Cells


Wednesday, April 02 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Wednesday, April 02 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch


Wednesday, April 02 | 11:00AM - 2:30PM
On Own for Lunch and Recreation


Wednesday, April 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch


Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
Room: Ballroom 1

Speaker 1 of 8
* Marc A. Elsliger, The Scripps Research Institute, USA
The Joint Center for Structural Genomics – A PSI:Biology Center for High-Throughput Structure Determination

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
Room: Ballroom 1

Speaker 2 of 8
Kelly Kai Li Hew, Nanyang Technological University, Singapore
Systems Structural Biology on Human Herpesviruses

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
Room: Ballroom 1

Speaker 3 of 8
Jürgen Haas, Swiss Institute of Bioinformatics, Switzerland
The ProteinModelPortal - How Good Is My Prediction? –First Results from the Continuous Automated Model EvaluatiOn (CAMEO)

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
Room: Ballroom 1

Speaker 4 of 8
Allyn J. Schoeffler, Genentech, USA
The Dynamics of cIAP1 Are Precisely Tuned for Rapid Activation

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
Room: Ballroom 1

Speaker 5 of 8
Ekaterina V. Filippova, Northwestern University, USA
Functional and Structural Characterization of GNAT Family of Acetyltransferases

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
Room: Ballroom 1

Speaker 6 of 8
Jeong Hyun Lee, The Scripps Research Institute, USA
Rapidly Uncovering New Epitopes on Viral Envelope Glycoproteins Using EM

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
Room: Ballroom 1

Speaker 7 of 8
Lenore Sparks, European Molecular Biology Laboratory, Germany
Positioning the Nup214 Subcomplex and Nup358 into the Human Nuclear Pore Complex

Wednesday, April 02 | 2:30PM - 4:30PM
Workshop 2: High-Throughput and Integrative Structural Biolo
gy
Room: Ballroom 1

Speaker 8 of 8
Peter S. Lee, The Scripps Research Institute, USA
Head Hunting: Targeting the Influenza Hemagglutinin Receptor Binding Site

Wednesday, April 02 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Wednesday, April 02 | 5:00PM - 7:00PM
Advances in Imaging Cellular Structure
Room: Ballroom 1

Speaker 1 of 4
* Andrew B. Ward, The Scripps Research Institute, USA

Wednesday, April 02 | 5:00PM - 7:00PM
Advances in Imaging Cellular Structure
Room: Ballroom 1

Speaker 2 of 4
Carolyn A. Larabell, University of California, San Francisco, USA
Correlated Fluorescence and X-Ray Tomography of Nuclear Organization and Chromatin Topology

Wednesday, April 02 | 5:00PM - 7:00PM
Advances in Imaging Cellular Structure
Room: Ballroom 1

Speaker 3 of 4
John Briggs, European Molecular Biology Laboratory, Germany
Determining Structures in situ – Advances in Subtomogram Averaging and in Correlative Light/Electron Microscopy

Wednesday, April 02 | 5:00PM - 7:00PM
Advances in Imaging Cellular Structure
Room: Ballroom 1

Speaker 4 of 4
Erik M. Jorgensen, University of Utah, USA
Flash-and-Freeze Electron Microscopy Reveals Dynamic Cellular Events

Wednesday, April 02 | 5:00PM - 7:00PM
Targeting GPCRs in Cancer and Inflammation
This session is from GPCRs
Room: Ballroom 2-3

Speaker 1 of 5
* Patrick M. Sexton, Monash University, Australia


Wednesday, April 02 | 5:00PM - 7:00PM
Targeting GPCRs in Cancer and Inflammation
This session is from GPCRs
Room: Ballroom 2-3

Speaker 2 of 5
Xavier J. Leroy, ITEOS Therapeutics, Belgium
FPR2 Agonists in Inflammatory Disease


Wednesday, April 02 | 5:00PM - 7:00PM
Targeting GPCRs in Cancer and Inflammation
This session is from GPCRs
Room: Ballroom 2-3

Speaker 3 of 5
Michael Hanson, GPCR Consortium, USA
S1P1 Receptor Structure and Ligand Analysis


Wednesday, April 02 | 5:00PM - 7:00PM
Targeting GPCRs in Cancer and Inflammation
This session is from GPCRs
Room: Ballroom 2-3

Speaker 4 of 5
Suzie Chen, Rutgers University, USA
Metabotropic Glutamate Receptor Signaling in Cancer


Wednesday, April 02 | 5:00PM - 7:00PM
Targeting GPCRs in Cancer and Inflammation
This session is from GPCRs
Room: Ballroom 2-3

Speaker 5 of 5
Sophie J. Bradley, University of Glasgow, UK
Short Talk: Targeting Muscarinic Receptors Rescues the Cognitive Deficit in Prion Neurodegenerative Disease in Mice


Wednesday, April 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch


Wednesday, April 02 | 7:30PM - 10:00PM
Poster Session 3
Room: Superior/Superior Lobby/Wasatch


Thursday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, April 03 | 8:00AM - 11:00AM
Extending Structural Knowledge through Informatics and Model
ing

Room: Ballroom 1

Speaker 1 of 6
* Ian A. Wilson, The Scripps Research Institute, USA

Thursday, April 03 | 8:00AM - 11:00AM
Extending Structural Knowledge through Informatics and Model
ing

Room: Ballroom 1

Speaker 2 of 6
Peter D. Kwong, NIAID, National Institutes of Health, USA
Informatics and Structure in Vaccine Design

Thursday, April 03 | 8:00AM - 11:00AM
Extending Structural Knowledge through Informatics and Model
ing

Room: Ballroom 1

Speaker 3 of 6
Jens Meiler, Vanderbilt University, USA
Modeling Membrane Proteins from Limited Experimental Data

Thursday, April 03 | 8:00AM - 11:00AM
Extending Structural Knowledge through Informatics and Model
ing

Room: Ballroom 1

Speaker 4 of 6
Andrej Sali, University of California, San Francisco, USA
Integrative Structural Biology

Thursday, April 03 | 8:00AM - 11:00AM
Extending Structural Knowledge through Informatics and Model
ing

Room: Ballroom 1

Speaker 5 of 6
Paul Robustelli, Columbia University, USA, USA
Short Talk: Tuning the Conformational Dynamics and Enzymatic Activity of Ribonuclease H

Thursday, April 03 | 8:00AM - 11:00AM
Extending Structural Knowledge through Informatics and Model
ing

Room: Ballroom 1

Speaker 6 of 6
Julien R. C. Bergeron, King's College London, UK
Short Talk: Architecture and Assembly of the Type 3 Secretion System Basal Body

Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System
This session is from GPCRs

Room: Ballroom 2-3

Speaker 1 of 7
* Arthur Christopoulos, Monash University, Australia


Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System
This session is from GPCRs

Room: Ballroom 2-3

Speaker 2 of 7
Brigitte L. Kieffer, Douglas Institute, Canada
In vivo Signaling of Opioid Receptors


Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System
This session is from GPCRs

Room: Ballroom 2-3

Speaker 3 of 7
Sebastien Granier, Institut de Génomique Fonctionnelle, France
Opioid Receptor Structural Pharmacology


Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System
This session is from GPCRs

Room: Ballroom 2-3

Speaker 4 of 7
Fiona H. Marshall, Heptares Therapeutics Ltd., UK
Structure-Based Drug Discovery Applied to CNS GPCRs


Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System
This session is from GPCRs

Room: Ballroom 2-3

Speaker 5 of 7
Gustavo Fenalti, Celgene Corporation, USA
Short Talk: Molecular Control of Delta-Opioid Receptor Signaling


Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System
This session is from GPCRs

Room: Ballroom 2-3

Speaker 6 of 7
David M. Thal, Monash Institute of Pharmaceutical Sciences, Australia
Short Talk: Structural Studies of the M4 Muscarinic Acetylcholine Receptor


Thursday, April 03 | 8:00AM - 11:15AM
Targeting GPCRs Involved in the Treatment of Diseases of the
Central Nervous System
This session is from GPCRs

Room: Ballroom 2-3

Speaker 7 of 7
AJ Venkatakrishnan, Stanford University, USA
Short Talk: Decoupled Modules of Atomic Contacts Mediate Stability and Orchestrate Activation of GPCRs


Thursday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Thursday, April 03 | 11:00AM - 5:00PM
On Own for Lunch and Recreation


Thursday, April 03 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Thursday, April 03 | 5:00PM - 6:15PM
Applications of Computation and Design
Room: Ballroom 1

Speaker 1 of 3
* Jens Meiler, Vanderbilt University, USA

Thursday, April 03 | 5:00PM - 6:15PM
Applications of Computation and Design
Room: Ballroom 1

Speaker 2 of 3
William F. DeGrado, University of California, San Francisco, USA
Analysis and Design of Proton Transporters

Thursday, April 03 | 5:00PM - 6:15PM
Applications of Computation and Design
Room: Ballroom 1

Speaker 3 of 3
Todd Yeates, University of California, Los Angeles, USA
Engineering Self-Assembling Protein Materials: Design Principles and Applications

Thursday, April 03 | 5:00PM - 6:15PM
Structure and Dynamics of GPCRs
This session is from GPCRs
Room: Ballroom 2

Speaker 1 of 3
* Christopher G. Tate, MRC Laboratory of Molecular Biology, UK


Thursday, April 03 | 5:00PM - 6:15PM
Structure and Dynamics of GPCRs
This session is from GPCRs
Room: Ballroom 2

Speaker 2 of 3
Reinhard Grisshammer, NIH/NINDS, USA
Structure of the Agonist-Bound Neurotensin Receptor NTS1


Thursday, April 03 | 5:00PM - 6:15PM
Structure and Dynamics of GPCRs
This session is from GPCRs
Room: Ballroom 2

Speaker 3 of 3
Vsevolod Katritch, University of Southern California, USA
Structures of the Major Antithrombotic Target P2Y12R Provide Key Insights into Function and Pharmacology of Purinergic GPCRs


Thursday, April 03 | 6:15PM - 7:15PM
Keynote Address (Joint)
Room: Ballroom 1-2

Speaker 1 of 1
Brian K. Kobilka, Stanford University School of Medicine, USA
Structural Insights into G Protein Coupled Receptor Signaling

Thursday, April 03 | 7:15PM - 7:30PM
Concluding Remarks (Joint)

Speaker 1 of 2
Christopher G. Tate, MRC Laboratory of Molecular Biology, UK

Thursday, April 03 | 7:15PM - 7:30PM
Concluding Remarks (Joint)

Speaker 2 of 2
Andrew B. Ward, The Scripps Research Institute, USA

Thursday, April 03 | 7:30PM - 8:30PM
Social Hour
Room: Ballroom Lobby


Thursday, April 03 | 8:00PM - 9:00PM
Lite Bites
Room: Ballroom 2-3


Thursday, April 03 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2-3


Thursday, April 03 | 8:30PM - 11:00PM
Cash Bar
Room: Ballroom Lobby


Friday, April 04 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.