Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Cellular Plasticity: Reprogramming, Regeneration and Metaplasia (2019J3)
Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering (2018T3)
iPSCs: A Decade of Progress and Beyond (2018C7)
Transcriptional and Epigenetic Control in Stem Cells (2017J1)
Stem Cells and Regeneration in the Digestive Organs (2016X6)
Transcriptional and Epigenetic Influences on Stem Cell States (2015C9)

Web Desc
Stem Cells and Reprogramming joint with Engineering Cell Fate and Function Organizer(s): Deepak Srivastava and Shinya Yamanaka Date: April 06 - 11, 2014 Location: Resort at Squaw Creek, Olympic Valley, CA, USA Sponsored by California Institute for Regenerative Medicine (CIRM), Life Technologies Corporation, Novartis Institutes for BioMedical Research, Sangamo BioSciences, Inc. and Vertex Pharmaceuticals Incorporated. Summary of Meeting: The fields of developmental and stem cell biology have revealed complex networks that regulate fundamental cell fate decisions. Such information was leveraged first to reprogram cells to induced pluripotent stem cells, and more recently to induce cell fate transitions from one somatic cell state directly into another, without involving a pluripotent stem cell phase. This conference will focus on the mechanisms underlying cellular pluripotency, differentiation, and reprogramming. These will include the understanding of signaling, transcriptional, translational and epigenetic events regulating cell fate transitions. The utility of such cellular regulation for disease modeling and regenerative medicine for multiple organ systems will be examined. Translational efforts in academic and industry that are moving toward regenerative medicine will be highlighted, as will efforts to use stem cell biology for drug discovery and evaluating drug toxicity. The emerging intersection of human genetics and stem cell biology that will lead to more personalized medicine will be a thematic focus woven into most sessions of this conference. Scholarship Deadline: December 10 2013 Discounted Abstract Deadline: December 10 2013 Abstract Deadline: January 15 2014 Discounted Registration Deadline: February 6 2014 Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting: We gratefully acknowledge additional support for this conference from: We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Sangamo BioSciences, Inc. Jeffrey M. Gimble Scholarship We gratefully acknowledge the generous grant for this conference provided by: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Grant No. 1R13HD079122-01 The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Stem Cells and Reprogramming

joint with Engineering Cell Fate and Function

Organizer(s): Deepak Srivastava and Shinya Yamanaka

Date: April 06 - 11, 2014
Location: Resort at Squaw Creek, Olympic Valley, CA, USA

Sponsored by California Institute for Regenerative Medicine (CIRM), Life Technologies Corporation, Novartis Institutes for BioMedical Research, Sangamo BioSciences, Inc. and Vertex Pharmaceuticals Incorporated.

Summary of Meeting:

The fields of developmental and stem cell biology have revealed complex networks that regulate fundamental cell fate decisions. Such information was leveraged first to reprogram cells to induced pluripotent stem cells, and more recently to induce cell fate transitions from one somatic cell state directly into another, without involving a pluripotent stem cell phase. This conference will focus on the mechanisms underlying cellular pluripotency, differentiation, and reprogramming. These will include the understanding of signaling, transcriptional, translational and epigenetic events regulating cell fate transitions. The utility of such cellular regulation for disease modeling and regenerative medicine for multiple organ systems will be examined. Translational efforts in academic and industry that are moving toward regenerative medicine will be highlighted, as will efforts to use stem cell biology for drug discovery and evaluating drug toxicity. The emerging intersection of human genetics and stem cell biology that will lead to more personalized medicine will be a thematic focus woven into most sessions of this conference.

Scholarship Deadline: December 10 2013

Discounted Abstract Deadline: December 10 2013

Abstract Deadline: January 15 2014

Discounted Registration Deadline: February 6 2014

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Sangamo BioSciences, Inc.

Jeffrey M. Gimble Scholarship

We gratefully acknowledge the generous grant for this conference provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Grant No. 1R13HD079122-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, April 06 \| 4:00PM - 8:00PM Arrival and Registration Room: Lobby Alcove
Sunday, April 06 \| 6:00PM - 8:00PM Welcome Mixer Room: Lobby Alcove
Monday, April 07 \| 7:00AM - 8:00AM Breakfast Room: Alpine Ballroom
Monday, April 07 \| 8:00AM - 9:00AM Keynote Address Room: Grand Sierra A-D Speaker 1 of 1 Karl Deisseroth, Stanford University, USA
Monday, April 07 \| 9:00AM - 9:30AM Coffee Break Room: Sierra Prefunction
Monday, April 07 \| 9:30AM - 11:45AM Regulation of Pluripotency I Room: Grand Sierra AB Speaker 1 of 6 * Deepak Srivastava, Gladstone Institutes, USA
Monday, April 07 \| 9:30AM - 11:45AM Regulation of Pluripotency I Room: Grand Sierra AB Speaker 2 of 6 John B. Gurdon, University of Cambridge, UK Transcriptional Reprogramming by Amphibian Eggs and Oocytes
Monday, April 07 \| 9:30AM - 11:45AM Regulation of Pluripotency I Room: Grand Sierra AB Speaker 3 of 6 Shinya Yamanaka, Center for iPS Cell Research and Application (CiRA), Kyoto University, Japan and Gladstone Institutes, San Francisco, Japan Recent Progress in iPS Cell Research and Application
Monday, April 07 \| 9:30AM - 11:45AM Regulation of Pluripotency I Room: Grand Sierra AB Speaker 4 of 6 Austin Smith, University of Cambridge, UK Ground-State Pluripotency
Monday, April 07 \| 9:30AM - 11:45AM Regulation of Pluripotency I Room: Grand Sierra AB Speaker 5 of 6 Bryce W. Carey, Rockefeller University, USA Short Talk: Metabolism Links Self-Renewal to Chromatin Regulation in Naïve Pluripotency
Monday, April 07 \| 9:30AM - 11:45AM Regulation of Pluripotency I Room: Grand Sierra AB Speaker 6 of 6 Carol F. Webb, University of Oklahoma Health Sciences Center, USA Short Talk: ARID3a Acts as a Barrier to Reprogramming by Repressing Human Oct4 Transcription
Monday, April 07 \| 9:30AM - 11:45AM Engineering Cells and Cell-Mimetic Particles to Impact Fate in vivo This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 1 of 5 * Jeffrey A. Hubbell, University of Chicago, USA
Monday, April 07 \| 9:30AM - 11:45AM Engineering Cells and Cell-Mimetic Particles to Impact Fate in vivo This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 2 of 5 Jeffrey Karp, Brigham and Women's Hospital, Harvard Medical School, USA Towards Bioengineered Control of Cell Fate Post-Transplantation
Monday, April 07 \| 9:30AM - 11:45AM Engineering Cells and Cell-Mimetic Particles to Impact Fate in vivo This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 3 of 5 Darrell J. Irvine, Massachusetts Institute of Technology, USA Engineering T Cells for Cancer and Infectious Disease
Monday, April 07 \| 9:30AM - 11:45AM Engineering Cells and Cell-Mimetic Particles to Impact Fate in vivo This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 4 of 5 Ana I. Teixeira, Karolinska Institutet, Sweden Short Talk: Spatial Control of Membrane Receptor Function Using Ligand Nano-Calipers
Monday, April 07 \| 9:30AM - 11:45AM Engineering Cells and Cell-Mimetic Particles to Impact Fate in vivo This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 5 of 5 Armon Sharei, SQZ Biotech, USA Short Talk: Engineering Immune Cell Function Using a Vector-Free Intracellular Delivery Platform
Monday, April 07 \| 11:45AM - 1:00PM Poster Setup Room: Alpine Ballroom
Monday, April 07 \| 11:45AM - 2:30PM On Own for Lunch and Recreation
Monday, April 07 \| 1:00PM - 10:00PM Poster Viewing Room: Alpine Ballroom
Monday, April 07 \| 2:30PM - 4:30PM Workshop 1 Room: Grand Sierra AB Speaker 1 of 8 * Shinya Yamanaka, Center for iPS Cell Research and Application (CiRA), Kyoto University, Japan and Gladstone Institutes, San Francisco, Japan
Monday, April 07 \| 2:30PM - 4:30PM Workshop 1 Room: Grand Sierra AB Speaker 2 of 8 Marina Bershteyn, University of California, San Francisco, USA Cell-Autonomous Correction of Ring Chromosomes in Human Induced Pluripotent Stem Cells
Monday, April 07 \| 2:30PM - 4:30PM Workshop 1 Room: Grand Sierra AB Speaker 3 of 8 Chulan Kwon, Johns Hopkins University, USA Precardiac Deletion of Numb and Numblike Reveals Renewal of Cardiac Progenitors
Monday, April 07 \| 2:30PM - 4:30PM Workshop 1 Room: Grand Sierra AB Speaker 4 of 8 Wenze Niu, University of Texas Southwestern Medical Center, USA Stepwise Conversion of Striatal Astrocytes to Neuroblasts and Mature Neurons in vivo
Monday, April 07 \| 2:30PM - 4:30PM Workshop 1 Room: Grand Sierra AB Speaker 5 of 8 Siim Pauklin, Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, UK Cell Fate Propensity Depends on the Cell Cycle State of the Stem Cell
Monday, April 07 \| 2:30PM - 4:30PM Workshop 1 Room: Grand Sierra AB Speaker 6 of 8 Abdenour Soufi, University of Edinburgh, UK Nucleosome-Binding Affinity as a Primary Determinant of the Pioneer Activity of Reprogramming Factors
Monday, April 07 \| 2:30PM - 4:30PM Workshop 1 Room: Grand Sierra AB Speaker 7 of 8 Nadja Zeltner, Memorial Sloan-Kettering Institute, USA Modeling Disease Severity in an iPSC-Based in vitro Model of Familial Dysautonomia
Monday, April 07 \| 2:30PM - 4:30PM Workshop 1 Room: Grand Sierra AB Speaker 8 of 8 Joel W. Blanchard, The Scripps Research Institute, USA Induction of Somatic Sensory Neural Lineage from Human and Mouse Fibroblasts
Monday, April 07 \| 4:30PM - 5:00PM Coffee Available Room: Sierra Prefunction
Monday, April 07 \| 5:00PM - 7:00PM Regulation of Pluripotency II Room: Grand Sierra AB Speaker 1 of 5 * Austin Smith, University of Cambridge, UK
Monday, April 07 \| 5:00PM - 7:00PM Regulation of Pluripotency II Room: Grand Sierra AB Speaker 2 of 5 Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA iPS Cell Technology, Gene Editing and Disease Research
Monday, April 07 \| 5:00PM - 7:00PM Regulation of Pluripotency II Room: Grand Sierra AB Speaker 3 of 5 Robert H. Blelloch, University of California, San Francisco, USA Alternative Paths to Induced Pluripotency as Defined by Two MicroRNA Loci
Monday, April 07 \| 5:00PM - 7:00PM Regulation of Pluripotency II Room: Grand Sierra AB Speaker 4 of 5 Kathrin Plath, University of California, Los Angeles, USA Insights into Reprogramming to Pluripotency
Monday, April 07 \| 5:00PM - 7:00PM Regulation of Pluripotency II Room: Grand Sierra AB Speaker 5 of 5 Ori Bar-Nur, Harvard university, USA Short Talk: Small Compounds Facilitate Rapid and Synchronous Reprogramming of Somatic Cells into iPS Cells by Defined Factors
Monday, April 07 \| 5:00PM - 7:00PM From Cells to Tissues (Assembly, Morphogenesis, Cell-Cell In teractions in Systems) This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 1 of 5 * Jennifer Elisseeff, Johns Hopkins University, USA
Monday, April 07 \| 5:00PM - 7:00PM From Cells to Tissues (Assembly, Morphogenesis, Cell-Cell In teractions in Systems) This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 2 of 5 Shulamit Levenberg, Technion - Israel Institute of Technology, Israel Cell Organization into 3D Tissue Structures
Monday, April 07 \| 5:00PM - 7:00PM From Cells to Tissues (Assembly, Morphogenesis, Cell-Cell In teractions in Systems) This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 3 of 5 Peter W. Zandstra, University of British Columbia, Canada Engineering Pluripotent Stem Cell Fate to Enable Human Cell- and Tissue-Based Drug Screening and Development
Monday, April 07 \| 5:00PM - 7:00PM From Cells to Tissues (Assembly, Morphogenesis, Cell-Cell In teractions in Systems) This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 4 of 5 Helen M. Blau, Stanford University, USA Synergy of Biochemical and Biophysical Cues Rejuvenates the Aged Stem Cell Population which Restores Strength to Aged Muscles
Monday, April 07 \| 5:00PM - 7:00PM From Cells to Tissues (Assembly, Morphogenesis, Cell-Cell In teractions in Systems) This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 5 of 5 Nathan Palpant, University of Queensland, Australia Short Talk: In vitro Titration of Wnt/beta-Catenin Signaling Enables Efficient Fate Specification of Lateral Plate Mesoderm Derivatives
Monday, April 07 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Alpine Ballroom
Monday, April 07 \| 7:30PM - 10:00PM Poster Session 1 Room: Alpine Ballroom
Tuesday, April 08 \| 7:00AM - 8:00AM Breakfast Room: Alpine Ballroom
Tuesday, April 08 \| 8:00AM - 11:15AM Direct Reprogramming (Transdifferentiation) Room: Grand Sierra AB Speaker 1 of 7 * Helen M. Blau, Stanford University, USA
Tuesday, April 08 \| 8:00AM - 11:15AM Direct Reprogramming (Transdifferentiation) Room: Grand Sierra AB Speaker 2 of 7 Deepak Srivastava, Gladstone Institutes, USA Reprogramming Approaches for Cardiovascular Disease
Tuesday, April 08 \| 8:00AM - 11:15AM Direct Reprogramming (Transdifferentiation) Room: Grand Sierra AB Speaker 3 of 7 Marius Wernig, Stanford University, USA Direct Lineage Reprogramming toward the Neural Lineage
Tuesday, April 08 \| 8:00AM - 11:15AM Direct Reprogramming (Transdifferentiation) Room: Grand Sierra AB Speaker 4 of 7 Gong Chen, Pennsylvania State University, USA Direct Neural Reprogramming in vivo for Brain Repair
Tuesday, April 08 \| 8:00AM - 11:15AM Direct Reprogramming (Transdifferentiation) Room: Grand Sierra AB Speaker 5 of 7 Sheng Ding, Gladstone Institute of Cardiovascular Disease and UC San Francisco, USA A Chemical Approach to Controlling Cell Fate
Tuesday, April 08 \| 8:00AM - 11:15AM Direct Reprogramming (Transdifferentiation) Room: Grand Sierra AB Speaker 6 of 7 Eva C. Thoma, Insphero AG, Switzerland Short Talk: Chemical Conversion of Human Fibroblasts into Functional Schwann Cells
Tuesday, April 08 \| 8:00AM - 11:15AM Direct Reprogramming (Transdifferentiation) Room: Grand Sierra AB Speaker 7 of 7 Yi-Ju Chen, USA Short Talk: De novo Formation of Insulin-Producing “Neo-Beta-Cell Islets” from Intestinal Crypts
Tuesday, April 08 \| 8:00AM - 11:15AM Redirecting Natural Processes This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 1 of 7 * Samuel I. Stupp, Northwestern University, USA
Tuesday, April 08 \| 8:00AM - 11:15AM Redirecting Natural Processes This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 2 of 7 David J. Mooney, Harvard University, USA Biomaterials to Control Immune Cell Trafficking and Activation
Tuesday, April 08 \| 8:00AM - 11:15AM Redirecting Natural Processes This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 3 of 7 Jeffrey A. Hubbell, University of Chicago, USA Molecular Engineering of Growth Factor – ECM Interactions
Tuesday, April 08 \| 8:00AM - 11:15AM Redirecting Natural Processes This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 4 of 7 Eric Lagasse, University of Pittsburgh, USA Growing a Surrogate Organ in Lymph Node: From an Experimental Approach to Potential Cinical Applications
Tuesday, April 08 \| 8:00AM - 11:15AM Redirecting Natural Processes This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 5 of 7 Jennifer Elisseeff, Johns Hopkins University, USA Biomaterial Approaches for Controlling Cell Function and Healing Processes
Tuesday, April 08 \| 8:00AM - 11:15AM Redirecting Natural Processes This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 6 of 7 Zhen Ma, University of California, Berkeley, USA Short Talk: Biophysical Cues for Spatially Differentiating Human Induced Pluripotent Stem Cells into Cardiac Lineage
Tuesday, April 08 \| 8:00AM - 11:15AM Redirecting Natural Processes This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 7 of 7 Gustavo P. Garlet, São Paulo University, Brazil Short Talk: Tregs Chemoattraction Triggers the Redirecting of MSCs Toward a Pro-Reparative and Pro-Immunosuppressive Phenotype that Actively Contributes to Experimental Periodontitis Attenuation
Tuesday, April 08 \| 9:20AM - 9:40AM Coffee Break Room: Sierra Prefunction
Tuesday, April 08 \| 11:15AM - 1:00PM Poster Setup Room: Alpine Ballroom
Tuesday, April 08 \| 11:15AM - 5:00PM On Own for Lunch and Recreation
Tuesday, April 08 \| 1:00PM - 10:00PM Poster Viewing Room: Alpine Ballroom
Tuesday, April 08 \| 4:30PM - 5:00PM Coffee Available Room: Sierra Prefunction
Tuesday, April 08 \| 5:00PM - 7:00PM Epigenetics of Reprogramming and Differentiation. Sess ion sponsored by Development. Room: Grand Sierra AB Support for these organizer-selected speakers generously provided by this journal. Speaker 1 of 5 * Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Tuesday, April 08 \| 5:00PM - 7:00PM Epigenetics of Reprogramming and Differentiation. Sess ion sponsored by Development. Room: Grand Sierra AB Support for these organizer-selected speakers generously provided by this journal. Speaker 2 of 5 Richard A. Young, Whitehead Institute for Biomedical Research, USA Epigenetic Landscape of Pluripotent Stem Cells
Tuesday, April 08 \| 5:00PM - 7:00PM Epigenetics of Reprogramming and Differentiation. Sess ion sponsored by Development. Room: Grand Sierra AB Support for these organizer-selected speakers generously provided by this journal. Speaker 3 of 5 Joanna Wysocka, Stanford University, USA Enhancer Landscapes in Pluripotency and Differentiation
Tuesday, April 08 \| 5:00PM - 7:00PM Epigenetics of Reprogramming and Differentiation. Sess ion sponsored by Development. Room: Grand Sierra AB Support for these organizer-selected speakers generously provided by this journal. Speaker 4 of 5 Benoit G. Bruneau, Gladstone Institutes, USA Epigenetic Regulation of Cardiac Lineage Development
Tuesday, April 08 \| 5:00PM - 7:00PM Epigenetics of Reprogramming and Differentiation. Sess ion sponsored by Development. Room: Grand Sierra AB Support for these organizer-selected speakers generously provided by this journal. Speaker 5 of 5 Alessandro Bertero, University of Washington, USA Short Talk: Activin Signaling Controls the Epigenetic Landscape of Human Pluripotent Stem Cells
Tuesday, April 08 \| 5:00PM - 7:15PM Models of Human Tissues - Healthy and Diseased This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 1 of 5 * Jason A. Burdick, University of Pennsylvania, USA
Tuesday, April 08 \| 5:00PM - 7:15PM Models of Human Tissues - Healthy and Diseased This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 2 of 5 Melody A. Swartz, University of Chicago, USA Manipulating Lymphatic Endothelial Cells for Immunomodulation
Tuesday, April 08 \| 5:00PM - 7:15PM Models of Human Tissues - Healthy and Diseased This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 3 of 5 Donald E. Ingber, Wyss Institute for Biologically Inspired Engineering at Harvard, USA Microengineered Human Organs on Chips
Tuesday, April 08 \| 5:00PM - 7:15PM Models of Human Tissues - Healthy and Diseased This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 4 of 5 Claudia Fischbach-Teschl, Cornell University, USA Engineering Meets Cancer Biology: Experimental Models of Tumor Angiogenesis and Metastasis
Tuesday, April 08 \| 5:00PM - 7:15PM Models of Human Tissues - Healthy and Diseased This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 5 of 5 Fiona M. Watt, King's College London School of Medicine, UK Examining the Interactions between Keratinocytes and their Niche in Normal Epidermis and in Tumors
Tuesday, April 08 \| 7:00PM - 8:15PM Social Hour with Lite Bites Room: Alpine Ballroom
Tuesday, April 08 \| 7:30PM - 10:00PM Poster Session 2 Room: Alpine Ballroom
Wednesday, April 09 \| 7:00AM - 8:00AM Breakfast Room: Alpine Ballroom
Wednesday, April 09 \| 8:00AM - 11:15AM Modeling of Disease Room: Grand Sierra AB Speaker 1 of 7 * Hideyuki Okano, Keio University School of Medicine, Japan
Wednesday, April 09 \| 8:00AM - 11:15AM Modeling of Disease Room: Grand Sierra AB Speaker 2 of 7 Fred H. Gage, The Salk Institute for Biological Studies, USA Modeling of Complex Neurologic Disease
Wednesday, April 09 \| 8:00AM - 11:15AM Modeling of Disease Room: Grand Sierra AB Speaker 3 of 7 Adam Rosenthal, Bioverativ, USA iPSC Models of Alzheimer's Disease: From Platform to Therapeutic Candidate
Wednesday, April 09 \| 8:00AM - 11:15AM Modeling of Disease Room: Grand Sierra AB Speaker 4 of 7 Clive N. Svendsen, Cedars-Sinai Regenerative Medicine Institute, USA Modeling Spinal Muscular Atrophy (SMA), Amyotrophic Lateral Sclerosis (ALS) and Huntington’s Disease (HD) Using iPS Cells
Wednesday, April 09 \| 8:00AM - 11:15AM Modeling of Disease Room: Grand Sierra AB Speaker 5 of 7 Lior Gepstein, Technion-Israel Institute of Technology, Israel Modeling of Inherited Cardiac Disorders Using Induced Pluripotent Stem Cells
Wednesday, April 09 \| 8:00AM - 11:15AM Modeling of Disease Room: Grand Sierra AB Speaker 6 of 7 A. Sophie de Boer, Harvard University, USA Short Talk: Genetic Validation of a Therapeutic Target Derived from a Stem Cell Model of ALS
Wednesday, April 09 \| 8:00AM - 11:15AM Modeling of Disease Room: Grand Sierra AB Speaker 7 of 7 Chun-Li Zhang, University of Texas Southwestern Medical Center, USA Short Talk: Modeling Human Disease by Using Fibroblast-Converted Functional Motor Neurons
Wednesday, April 09 \| 8:00AM - 11:00AM In vivo Integration/Tolerance/Scaleup/Delivery of Cells and Tissues This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 1 of 6 * David J. Mooney, Harvard University, USA
Wednesday, April 09 \| 8:00AM - 11:00AM In vivo Integration/Tolerance/Scaleup/Delivery of Cells and Tissues This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 2 of 6 Daniel G. Anderson, Massachusetts Institute of Technology, USA Combinatorial Development of Biomaterials for Cellular Delivery
Wednesday, April 09 \| 8:00AM - 11:00AM In vivo Integration/Tolerance/Scaleup/Delivery of Cells and Tissues This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 3 of 6 Jason A. Burdick, University of Pennsylvania, USA Engineering Cardiac Tissue Response Post-Infarction through Biomaterial Design
Wednesday, April 09 \| 8:00AM - 11:00AM In vivo Integration/Tolerance/Scaleup/Delivery of Cells and Tissues This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 4 of 6 Samuel I. Stupp, Northwestern University, USA Signaling and Targeting Cells with Extracellular Supramolecular Structures
Wednesday, April 09 \| 8:00AM - 11:00AM In vivo Integration/Tolerance/Scaleup/Delivery of Cells and Tissues This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 5 of 6 Joseph T. Rodgers, University of Southern California Keck School of Medicine, USA Short Talk: Harnessing Physiologic Responses by Quiescent Stem Cells to Improve Wound Repair and Tissue Regeneration
Wednesday, April 09 \| 8:00AM - 11:00AM In vivo Integration/Tolerance/Scaleup/Delivery of Cells and Tissues This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 6 of 6 Yubing Sun, University of Michigan, Ann Arbor, USA Short Talk: Biophysical Regulation of Functional Motor Neuron Generation from Human Pluripotent Stem Cells
Wednesday, April 09 \| 9:20AM - 9:40AM Coffee Break Room: Sierra Prefunction
Wednesday, April 09 \| 11:15AM - 1:00PM Poster Setup Room: Alpine Ballroom
Wednesday, April 09 \| 11:15AM - 2:30PM On Own for Lunch and Recreation
Wednesday, April 09 \| 1:00PM - 10:00PM Poster Viewing Room: Alpine Ballroom
Wednesday, April 09 \| 2:30PM - 4:30PM Workshop 2: Clinical Progress for Stem Cell Therapies. Organ ized in collaboration with California Institute for Regenerative Medicine (CIRM) Room: Grand Sierra AB Speaker 1 of 6 * Ellen G. Feigal, USA
Wednesday, April 09 \| 2:30PM - 4:30PM Workshop 2: Clinical Progress for Stem Cell Therapies. Organ ized in collaboration with California Institute for Regenerative Medicine (CIRM) Room: Grand Sierra AB Speaker 2 of 6 Eva L. Feldman, University of Michigan, USA Intraspinal Stem Cell Transplantation in ALS: Results of a Phase I Clinical Trial
Wednesday, April 09 \| 2:30PM - 4:30PM Workshop 2: Clinical Progress for Stem Cell Therapies. Organ ized in collaboration with California Institute for Regenerative Medicine (CIRM) Room: Grand Sierra AB Speaker 3 of 6 Robert Lanza, Astellas Pharma Inc., USA ES- and iPS-Derived Cells for Clinical Trials
Wednesday, April 09 \| 2:30PM - 4:30PM Workshop 2: Clinical Progress for Stem Cell Therapies. Organ ized in collaboration with California Institute for Regenerative Medicine (CIRM) Room: Grand Sierra AB Speaker 4 of 6 Philip D. Gregory, Bluebird Bio, USA Genome Editing with Zinc Finger Nucleases: A Novel Apporach to HIV Therapy
Wednesday, April 09 \| 2:30PM - 4:30PM Workshop 2: Clinical Progress for Stem Cell Therapies. Organ ized in collaboration with California Institute for Regenerative Medicine (CIRM) Room: Grand Sierra AB Speaker 5 of 6 Kevin A. D'Amour, ViaCyte, Inc., USA Development of an Encapsulated Stem Cell-Based Therapy for Diabetes
Wednesday, April 09 \| 2:30PM - 4:30PM Workshop 2: Clinical Progress for Stem Cell Therapies. Organ ized in collaboration with California Institute for Regenerative Medicine (CIRM) Room: Grand Sierra AB Speaker 6 of 6 Tracy C. Grikscheit, Children's Hospital Los Angeles, USA Defining the Function of Tissue-Engineered Intestine Generated from Human Postnatal Progenitor Cells in a Murine Model
Wednesday, April 09 \| 4:30PM - 5:00PM Coffee Available Room: Sierra Prefunction
Wednesday, April 09 \| 5:00PM - 7:15PM iPS Models of Disease (Joint) Room: Grand Sierra A-D Speaker 1 of 6 * Christopher S. Chen, Boston University, USA
Wednesday, April 09 \| 5:00PM - 7:15PM iPS Models of Disease (Joint) Room: Grand Sierra A-D Speaker 2 of 6 Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA Modeling Disease Severity in an iPSC-Based in vitro Model of Familial Dysautonomia
Wednesday, April 09 \| 5:00PM - 7:15PM iPS Models of Disease (Joint) Room: Grand Sierra A-D Speaker 3 of 6 George Q. Daley, HHMI/Boston Children's Hospital, USA Dissecting Reprogramming, Differentiation and Conversion with Network Biology
Wednesday, April 09 \| 5:00PM - 7:15PM iPS Models of Disease (Joint) Room: Grand Sierra A-D Speaker 4 of 6 Sangeeta N. Bhatia, Massachusetts Institute of Technology, USA Disease Modeling of Human Hepatotropic Infections in iPS Cells
Wednesday, April 09 \| 5:00PM - 7:15PM iPS Models of Disease (Joint) Room: Grand Sierra A-D Speaker 5 of 6 Mo Mandegar, Tenaya Therapeutics, USA Short Talk: Cardiac Disease Modeling Using Engineered Human iPS Cell-Derived Cardiomyocytes
Wednesday, April 09 \| 5:00PM - 7:15PM iPS Models of Disease (Joint) Room: Grand Sierra A-D Speaker 6 of 6 Michela Deleidi, German Center for Neurodegenerative Diseases, Germany Short Talk: Modeling GBA1-Associated Parkinson's Disease Using Patient iPSCs Reveals Defects in the Lysosomal Machinery and Calcium Homeostasis
Wednesday, April 09 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Alpine Ballroom
Wednesday, April 09 \| 7:30PM - 10:00PM Poster Session 3 Room: Alpine Ballroom
Thursday, April 10 \| 7:00AM - 8:00AM Breakfast Room: Alpine Ballroom
Thursday, April 10 \| 8:00AM - 11:15AM Translational Applications of Stem Cells Room: Grand Sierra AB Speaker 1 of 6 * Fred H. Gage, The Salk Institute for Biological Studies, USA
Thursday, April 10 \| 8:00AM - 11:15AM Translational Applications of Stem Cells Room: Grand Sierra AB Speaker 2 of 6 Hideyuki Okano, Keio University School of Medicine, Japan Modeling Neurological and Psychiatric Disorders Using iPSCs Technologies and Transgenic Non-Human Primates
Thursday, April 10 \| 8:00AM - 11:15AM Translational Applications of Stem Cells Room: Grand Sierra AB Speaker 3 of 6 Masayo Takahashi, RIKEN Center for Developmental Biology, Japan Retinal Cell Therapy Using iPS Cells
Thursday, April 10 \| 8:00AM - 11:15AM Translational Applications of Stem Cells Room: Grand Sierra AB Speaker 4 of 6 Leonard I. Zon, HHMI/Boston Children's Hospital, USA Pathways Regulating Stem Cell Induction, Self-Renewal and Engraftment
Thursday, April 10 \| 8:00AM - 11:15AM Translational Applications of Stem Cells Room: Grand Sierra AB Speaker 5 of 6 Lei (Stanley) Qi, Stanford University, USA Short Talk: Engineering of the Genome Using CRSPR Technology
Thursday, April 10 \| 8:00AM - 11:15AM Translational Applications of Stem Cells Room: Grand Sierra AB Speaker 6 of 6 Christina V. Theodoris, University of California, San Francisco, USA Short Talk: iPSC-based Modeling of Human NOTCH1 Mutations Reveals Novel Pathways Regulating Calcific Aortic Valve Disease
Thursday, April 10 \| 8:00AM - 11:15AM Engineering Mammalian Cells with Synthetic Biology This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 1 of 7 * Darrell J. Irvine, Massachusetts Institute of Technology, USA
Thursday, April 10 \| 8:00AM - 11:15AM Engineering Mammalian Cells with Synthetic Biology This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 2 of 7 Ron Weiss, Massachusetts Institute of Technology, USA Synthetic Biology: From Parts to Modules to Therapeutic Systems
Thursday, April 10 \| 8:00AM - 11:15AM Engineering Mammalian Cells with Synthetic Biology This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 3 of 7 Patrick D. Hsu, University of California, Berkeley, USA Genome Engineering: Technologies and Applications
Thursday, April 10 \| 8:00AM - 11:15AM Engineering Mammalian Cells with Synthetic Biology This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 4 of 7 Wendell A. Lim, University of California, San Francisco, USA Exploring and Exploiting the Design Principles of Cell Signaling Networks
Thursday, April 10 \| 8:00AM - 11:15AM Engineering Mammalian Cells with Synthetic Biology This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 5 of 7 Martin Fussenegger, ETH Zürich, Switzerland Prosthetic Networks – Synthetic Biology-Inspired Treatment Strategies for Metabolic Disorders
Thursday, April 10 \| 8:00AM - 11:15AM Engineering Mammalian Cells with Synthetic Biology This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 6 of 7 Victor D. Fedorov, Memorial Sloan-Kettering Cancer Center, USA Short Talk: iCARs: Novel Engineered Cell-Intrinsic Safety Switches for Prevention of Immunotherapy Toxicities
Thursday, April 10 \| 8:00AM - 11:15AM Engineering Mammalian Cells with Synthetic Biology This session is from Engineering Cell Fate Room: Grand Sierra CD Speaker 7 of 7 Samantha A. Morris, Washington University in St Louis, USA Short Talk: Enhancing Cellular Engineering through Network Biology
Thursday, April 10 \| 9:20AM - 9:40AM Coffee Break Room: Sierra Prefunction
Thursday, April 10 \| 11:15AM - 5:00PM On Own for Lunch and Recreation
Thursday, April 10 \| 4:30PM - 5:00PM Coffee Available Room: Sierra Prefunction
Thursday, April 10 \| 5:00PM - 7:15PM Cellular Microenvironments/Synthetic Niches to Control Cell Fate (Joint) Room: Grand Sierra A-D Speaker 1 of 6 * Sangeeta N. Bhatia, Massachusetts Institute of Technology, USA
Thursday, April 10 \| 5:00PM - 7:15PM Cellular Microenvironments/Synthetic Niches to Control Cell Fate (Joint) Room: Grand Sierra A-D Speaker 2 of 6 Christopher S. Chen, Boston University, USA Mechanoregulation: Linking Adhesion, Force, Form and Function
Thursday, April 10 \| 5:00PM - 7:15PM Cellular Microenvironments/Synthetic Niches to Control Cell Fate (Joint) Room: Grand Sierra A-D Speaker 3 of 6 Jennifer A. Lewis, Harvard University, SEAS, USA 3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs
Thursday, April 10 \| 5:00PM - 7:15PM Cellular Microenvironments/Synthetic Niches to Control Cell Fate (Joint) Room: Grand Sierra A-D Speaker 4 of 6 Kristi S. Anseth, HHMI/University of Colorado, USA Phototunable Hydrogels as Dynamic Cell Niches
Thursday, April 10 \| 5:00PM - 7:15PM Cellular Microenvironments/Synthetic Niches to Control Cell Fate (Joint) Room: Grand Sierra A-D Speaker 5 of 6 Helen M. Blau, Stanford University, USA Short Talk: Rejuvenated Muscle Stem Cell Population Increases Strength in Aged Muscles
Thursday, April 10 \| 5:00PM - 7:15PM Cellular Microenvironments/Synthetic Niches to Control Cell Fate (Joint) Room: Grand Sierra A-D Speaker 6 of 6 Haiyang Chen, Carnegie Institution for Science, USA Short Talk: Nuclear Lamina Regulates Stem-Cell Niche Organization through Integration Nuclear Structure and EGFR Signaling
Thursday, April 10 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Alpine Ballroom
Thursday, April 10 \| 8:00PM - 11:00PM Entertainment Room: Alpine Ballroom
Thursday, April 10 \| 8:00PM - 11:00PM Cash Bar Room: Alpine Ballroom
Friday, April 11 \| 10:25AM - 10:25AM Departure *Session Chair.