Web Desc
Epigenetics and Cancer
Organizer(s): Tony Kouzarides and Kristian Helin
Date: January 25 - 30, 2015
Location: Keystone Resort, Keystone, CO, USA
Sponsored by AstraZeneca, Bayer HealthCare Pharmaceuticals, Cell Research, Cell Signaling Technology, Inc., Constellation Pharmaceuticals and Incyte Corporation. Supported by an educational grant from Celgene Corporation.
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Summary of Meeting:
Cancer epigenetics is a new and rapidly developing area of research. This results from the discovery that many epigenetic regulators (chromatin modifying enzymes, modification-reading proteins and chromatin-remodeling activities) are found mutated in cancers and has led to the recent approval of cancer drugs targeting epigenetic enzymes. The meeting aims to bring together scientists who are interested in understanding the connections between basic epigenetic pathways and the process of cancer. One aspect of the meeting will highlight the mechanisms by which epigenetic pathways control various biological processes. Information will be presented on chromatin and DNA modifications, chromatin complexes and ncRNAs. A second aspect will revolve around the connections between epigenetic pathways and cancer. This section will highlight genetic and epigenetic changes that take place during oncogenesis and efforts to counteract cancer with small molecule inhibitors against epigenetic regulators. The hope is to provide a forum for the interchange of information and know-how between the two converging fields of cancer research and epigenetics.
Scholarship Deadline: September 30 2014
Discounted Abstract Deadline: September 30 2014
Abstract Deadline: October 23 2014
Discounted Registration Deadline: November 24 2014
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZenecaBayer HealthCare Pharmaceuticals
Educational grant from Celgene Corporation
Cell Signaling Technology, Inc.Cell ResearchConstellation PharmaceuticalsIncyte Corporation
We gratefully acknowledge additional support for this conference from:
Abcam plcBethyl Laboratories, Inc.InventivaSigma Life ScienceZymo Research Corporation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Constellation Pharmaceuticals

Epizyme, Inc.

Pfizer Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA189412-01
Funding for this conference was made possible (in part) by 1R13CA189412-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 25 | 4:00PM - 8:00PM
Arrival and Registration
Room: Longs Peak Foyer


Sunday, January 25 | 6:00PM - 8:00PM
Welcome Mixer
Room: Longs Peak Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Monday, January 26 | 8:00AM - 11:15AM
Epigenetic Modifications and Cancer
Room: Grays Peak

Speaker 1 of 7
* Luciano Di Croce, CRG - Center for Genomic Regulation, Spain

Monday, January 26 | 8:00AM - 11:15AM
Epigenetic Modifications and Cancer
Room: Grays Peak

Speaker 2 of 7
Ali Shilatifard, Northwestern University, USA
Enhancer Malfunction in Cancer

Monday, January 26 | 8:00AM - 11:15AM
Epigenetic Modifications and Cancer
Room: Grays Peak

Speaker 3 of 7
Kristian Helin, University of Copenhagen and Memorial Sloan Kettering Cancer Center, Denmark
Histone Methylation in Differentiation and Disease

Monday, January 26 | 8:00AM - 11:15AM
Epigenetic Modifications and Cancer
Room: Grays Peak

Speaker 4 of 7
Peter Verrijzer, Erasmus University Medical Center, Netherlands
Short Talk: Chromatin Remodelers in Development and Disease

Monday, January 26 | 8:00AM - 11:15AM
Epigenetic Modifications and Cancer
Room: Grays Peak

Speaker 5 of 7
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Enhancer Structure and Function in Stem Cells and Cancer

Monday, January 26 | 8:00AM - 11:15AM
Epigenetic Modifications and Cancer
Room: Grays Peak

Speaker 6 of 7
Tony Kouzarides, University of Cambridge, UK
Epigenetic Modifications: Their Function and Role in Cancer

Monday, January 26 | 8:00AM - 11:15AM
Epigenetic Modifications and Cancer
Room: Grays Peak

Speaker 7 of 7
Tobias Neff, Children's Hospital Colorado, USA
Short Talk: Tumor Suppressor Functions of PRC2 in a Mouse Model of ETP-ALL

Monday, January 26 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, January 26 | 11:15AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Monday, January 26 | 11:15AM - 5:00PM
On Own for Lunch


Monday, January 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Monday, January 26 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 26 | 5:00PM - 7:15PM
Mechanisms of Epigenetic Signaling
Room: Grays Peak

Speaker 1 of 7
* Peter Verrijzer, Erasmus University Medical Center, Netherlands

Monday, January 26 | 5:00PM - 7:15PM
Mechanisms of Epigenetic Signaling
Room: Grays Peak

Speaker 2 of 7
Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA
RNA-Protein Interactions in Epigenetic Regulation

Monday, January 26 | 5:00PM - 7:15PM
Mechanisms of Epigenetic Signaling
Room: Grays Peak

Speaker 3 of 7
François Fuks, Université Libre de Bruxelles, Belgium
Short Talk: New Modes of Regulation of TET Enzymes and Hydroxymethylation

Monday, January 26 | 5:00PM - 7:15PM
Mechanisms of Epigenetic Signaling
Room: Grays Peak

Speaker 4 of 7
Gala Filippova, University of Washington, USA
Short Talk: CTCF-Mediated Epigenetic Stability as a Barrier to Neoplastic Progression

Monday, January 26 | 5:00PM - 7:15PM
Mechanisms of Epigenetic Signaling
Room: Grays Peak

Speaker 5 of 7
Salvador Aznar Benitah, ICREA and Institute for Research in Biomedicine, Spain
Short Talk: Enhancer Modulation by Dnmt3a and Dnmt3b Regulates Epidermal Stem Cell Homeostasis: ImpacE on Aging and Cancer

Monday, January 26 | 5:00PM - 7:15PM
Mechanisms of Epigenetic Signaling
Room: Grays Peak

Speaker 6 of 7
Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School, USA
Short Talk: Remodeling the Remodelers: BAF Complex Structure and Function in Human Cancer

Monday, January 26 | 5:00PM - 7:15PM
Mechanisms of Epigenetic Signaling
Room: Grays Peak

Speaker 7 of 7
Ramin Shiekhattar, University of Miami, USA
Biogenesis and Mechanism of Action of enhancer RNAs

Monday, January 26 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Monday, January 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Tuesday, January 27 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Tuesday, January 27 | 8:00AM - 11:15AM
Components of Epigenetic Pathways
Room: Grays Peak

Speaker 1 of 7
* Johnathan R. Whetstine, Fox Chase Cancer Center, USA

Tuesday, January 27 | 8:00AM - 11:15AM
Components of Epigenetic Pathways
Room: Grays Peak

Speaker 2 of 7
Shelley L. Berger, University of Pennsylvania, USA
Novel Epigenetic Signatures of Wild Type and Mutant p53 Transcriptional Activity

Tuesday, January 27 | 8:00AM - 11:15AM
Components of Epigenetic Pathways
Room: Grays Peak

Speaker 3 of 7
Danny F. Reinberg, HHMI/New York University, USA
Chromatin Regulation by Polycomb Complexes

Tuesday, January 27 | 8:00AM - 11:15AM
Components of Epigenetic Pathways
Room: Grays Peak

Speaker 4 of 7
Adrian P. Bracken, Trinity College Dublin, Ireland
Short Talk: Divergent and Overlapping Functions of Polycomb–Like Proteins in the Control of Cellular Proliferation.

Tuesday, January 27 | 8:00AM - 11:15AM
Components of Epigenetic Pathways
Room: Grays Peak

Speaker 5 of 7
Luciano Di Croce, CRG - Center for Genomic Regulation, Spain
Unveiling Polycomb Functions in Stem Cells and Cancer

Tuesday, January 27 | 8:00AM - 11:15AM
Components of Epigenetic Pathways
Room: Grays Peak

Speaker 6 of 7
Diego Pasini, European Institute of Oncology, Italy
Short Talk: Function and Mechanism of Action of the Polycomb Repressive Complex 1 in the Homeostasis of Adult Intestinal Stem Cells

Tuesday, January 27 | 8:00AM - 11:15AM
Components of Epigenetic Pathways
Room: Grays Peak

Speaker 7 of 7
Thomas Jenuwein, Max Planck Institute of Immunobiology and Epigenetics, Germany
Suv39h-Dependent H3K9me3 Represses Intact Retrotransposons in Mouse Embryonic Stem Cells

Tuesday, January 27 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, January 27 | 11:15AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Tuesday, January 27 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, January 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Tuesday, January 27 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 27 | 5:00PM - 7:00PM
Epigenetic Changes in Stem Cells and Cancer
Room: Grays Peak

Speaker 1 of 5
* Salvador Aznar Benitah, ICREA and Institute for Research in Biomedicine, Spain

Tuesday, January 27 | 5:00PM - 7:00PM
Epigenetic Changes in Stem Cells and Cancer
Room: Grays Peak

Speaker 2 of 5
James E. Bradner, Novartis Institutes for BioMedical Research, USA
Disruption of Super Enhancers in Cancer Therapy

Tuesday, January 27 | 5:00PM - 7:00PM
Epigenetic Changes in Stem Cells and Cancer
Room: Grays Peak

Speaker 3 of 5
Christopher Vakoc, Cold Spring Harbor Laboratory, USA
Chromatin Regulators as Cancer Dependencies

Tuesday, January 27 | 5:00PM - 7:00PM
Epigenetic Changes in Stem Cells and Cancer
Room: Grays Peak

Speaker 4 of 5
Johnathan R. Whetstine, Fox Chase Cancer Center, USA
Short Talk: Understanding Copy Number Variation through Chromatin Modulation

Tuesday, January 27 | 5:00PM - 7:00PM
Epigenetic Changes in Stem Cells and Cancer
Room: Grays Peak

Speaker 5 of 5
Miguel N. Rivera, Massachusetts General Hospital / Harvard Medical School, USA
Short Talk: EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Induce or Repress Enhancers in Ewing Sarcoma

Tuesday, January 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Tuesday, January 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Shavano/Torreys


Wednesday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Wednesday, January 28 | 8:00AM - 11:15AM
Epigenetics in Hematopoietic Tumors
Room: Grays Peak

Speaker 1 of 7
* Christopher Vakoc, Cold Spring Harbor Laboratory, USA

Wednesday, January 28 | 8:00AM - 11:15AM
Epigenetics in Hematopoietic Tumors
Room: Grays Peak

Speaker 2 of 7
Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA
Role of Mutations in Epigenetic Regulators in Pathogenesis of Myeloid Malignancies

Wednesday, January 28 | 8:00AM - 11:15AM
Epigenetics in Hematopoietic Tumors
Room: Grays Peak

Speaker 3 of 7
Iannis Aifantis, New York University School of Medicine, USA
Cytosine Hydroxy-Methylating Enzymes in the Control of Leukemia Initiation and Progression

Wednesday, January 28 | 8:00AM - 11:15AM
Epigenetics in Hematopoietic Tumors
Room: Grays Peak

Speaker 4 of 7
Toshio Kitamura, University of Tokyo, Institute of Medical Science, Japan
Short Talk: MDS Induced by ASXL1 Mutations and its Leukemic Transformation by an Additional SETBP1 Mutation

Wednesday, January 28 | 8:00AM - 11:15AM
Epigenetics in Hematopoietic Tumors
Room: Grays Peak

Speaker 5 of 7
Johannes Zuber, Research Institute of Molecular Pathology, Austria
Comparative Analysis of Chromatin Dependencies in Leukemia Using Advanced RNAi

Wednesday, January 28 | 8:00AM - 11:15AM
Epigenetics in Hematopoietic Tumors
Room: Grays Peak

Speaker 6 of 7
Mark A. Dawson, Peter MacCallum Cancer Centre, Australia
Short Talk: Targeting Epigenetic Regulators in Haematological Malignancies

Wednesday, January 28 | 8:00AM - 11:15AM
Epigenetics in Hematopoietic Tumors
Room: Grays Peak

Speaker 7 of 7
Scott A. Armstrong, Dana-Farber Cancer Institute, USA
Targeting Histone Modifications and Hox Gene Expression in Leukemia

Wednesday, January 28 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, January 28 | 11:15AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Wednesday, January 28 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Wednesday, January 28 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 28 | 5:00PM - 7:15PM
Epigenetics Meets Genetics
Room: Grays Peak

Speaker 1 of 6
* † Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School, USA

Wednesday, January 28 | 5:00PM - 7:15PM
Epigenetics Meets Genetics
Room: Grays Peak

Speaker 2 of 6
Peter Campbell, Wellcome Trust Sanger Institute, UK
Interrogating the Architecture of Cancer Genomes

Wednesday, January 28 | 5:00PM - 7:15PM
Epigenetics Meets Genetics
Room: Grays Peak

Speaker 3 of 6
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
TET proteins, 5-methylcytosine oxidation and cancer

Wednesday, January 28 | 5:00PM - 7:15PM
Epigenetics Meets Genetics
Room: Grays Peak

Speaker 4 of 6
Berkley Eric Gryder, NCI, National Institutes of Health, USA
Short Talk: Genetic, Epigenetic and Molecular Sensitivity Landscape of Pediatric Rhabdomyosarcoma

Wednesday, January 28 | 5:00PM - 7:15PM
Epigenetics Meets Genetics
Room: Grays Peak

Speaker 5 of 6
Charles M. Roberts, Dana-Farber Cancer Institute, Harvard Medical School, USA
SWI/SNF Chromatin Remodeling Complexes in Cancer

Wednesday, January 28 | 5:00PM - 7:15PM
Epigenetics Meets Genetics
Room: Grays Peak

Speaker 6 of 6
Christine Fillmore Brainson, University of Kentucky, USA
Short Talk: EZH2 Inhibition Sensitizes BRG1 and EGFR Mutant lung Tumors to TopoII Inhibitors

Wednesday, January 28 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Wednesday, January 28 | 7:30PM - 10:00PM
Poster Session 3
Room: Shavano/Torreys


Thursday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Thursday, January 29 | 8:00AM - 11:15AM
Epigenetic Cancer Therapies I
Room: Grays Peak

Speaker 1 of 7
* Mark A. Dawson, Peter MacCallum Cancer Centre, Australia

Thursday, January 29 | 8:00AM - 11:15AM
Epigenetic Cancer Therapies I
Room: Grays Peak

Speaker 2 of 7
Patrick Trojer, Constellation Pharmaceuticals, USA
EZH2 Represses Interferon Signaling in Lymphoma

Thursday, January 29 | 8:00AM - 11:15AM
Epigenetic Cancer Therapies I
Room: Grays Peak

Speaker 3 of 7
George P. Souroullas, University of North Carolina, USA
Short Talk: Mechanistic Understanding of the Ezh2Y641F Mutation in Lymphoma

Thursday, January 29 | 8:00AM - 11:15AM
Epigenetic Cancer Therapies I
Room: Grays Peak

Speaker 4 of 7
Heike Keilhack, Epizyme, Inc, USA
EZH2 as a Target for Genetically Defined Cancers

Thursday, January 29 | 8:00AM - 11:15AM
Epigenetic Cancer Therapies I
Room: Grays Peak

Speaker 5 of 7
Rab K. Prinjha, GlaxoSmithKline, UK
Short Talk: Epigenetics Drug-Discovery: From Target to Patients with BET Bromodomain Inhibitors

Thursday, January 29 | 8:00AM - 11:15AM
Epigenetic Cancer Therapies I
Room: Grays Peak

Speaker 6 of 7
Christopher L. Carpenter, Rubius Therapeutics, USA
Targeting Epigenetic Pathways to Treat Cancer

Thursday, January 29 | 8:00AM - 11:15AM
Epigenetic Cancer Therapies I
Room: Grays Peak

Speaker 7 of 7
Alexander Tarakhovsky, Rockefeller University, USA
Abrogation of T Cell Immunity by the Ezh2 Inactivation

Thursday, January 29 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, January 29 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, January 29 | 5:00PM - 7:00PM
Epigenetic Cancer Therapies II
Room: Grays Peak

Speaker 1 of 5
* Rab K. Prinjha, GlaxoSmithKline, UK

Thursday, January 29 | 5:00PM - 7:00PM
Epigenetic Cancer Therapies II
Room: Grays Peak

Speaker 2 of 5
Stefan Knapp, University of Oxford, UK
Towards a Chemical Probe Set Targeting the Human Bromodomain Family

Thursday, January 29 | 5:00PM - 7:00PM
Epigenetic Cancer Therapies II
Room: Grays Peak

Speaker 3 of 5
Daniela Kleine-Kohlbrecher, EpiTherapeutics Aps, Denmark
Short Talk: The Development of Therapeutic Inhibitors of the KDM5 Histone Demethylases

Thursday, January 29 | 5:00PM - 7:00PM
Epigenetic Cancer Therapies II
Room: Grays Peak

Speaker 4 of 5
Thomas Paul, Pfizer Worldwide Research and Development, USA
Targeting SMARCA2/4 in SWI/SNF Mutant Cancers

Thursday, January 29 | 5:00PM - 7:00PM
Epigenetic Cancer Therapies II
Room: Grays Peak

Speaker 5 of 5
Nicholas J. Keen, Novartis Institutes for BioMedical Research, USA
Systematic Approaches to Targeting Epigenetic Regulators in Cancer

Thursday, January 29 | 7:00PM - 7:30PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Grays Peak


Thursday, January 29 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Thursday, January 29 | 8:00PM - 11:00PM
Entertainment
Room: Shavano/Torreys
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 29 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Friday, January 30 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.