Web Desc
Neuroinflammation in Diseases of the Central Nervous System
Organizer(s): Richard M. Ransohoff, Christopher K. Glass and V. Hugh Perry
Date: January 25 - 30, 2015
Location: Sagebrush Inn & Suites, Taos, NM, USA
Sponsored by Abide Therapeutics Inc., Biogen Idec, FORUM Pharmaceuticals Inc., Shire Human Genetic Therapies and Takeda Pharmaceutical Company Limited. Supported by an educational donation provided by Amgen.
Summary of Meeting:
Neuroinflammation, the response of the central nervous system (CNS) to disturbed homeostasis, typifies all neurological diseases, including primary-inflammatory, developmental, traumatic, ischemic, neoplastic and neurodegenerative. Disease-associated neuroinflammatory responses may be helpful, harmful or neutral. This Keystone Symposia meeting will: (i) address the developmental roles of neuroinflammatory cells including microglia and blood-brain barrier (BBB) neurovascular elements; (ii) clarify how neuroinflammatory reactions mediate host defense against neuroinvasive microbial pathogens, and also how the response to systemic inflammation affects the neuroinflammatory elements; (iii) specify critically-important neuroinflammatory cells (microglia; astrocytes; NG2+ glia; BBB), receptors (toll-like receptors; inflammasomes; cytokine receptors), signaling pathways and effector mechanisms; and (iv) identify the most salient targets of neuroinflammation (neurons; neural progenitor and stem cells; oligodendroglia) and mechanisms of injury. This meeting will be the first Keystone Symposia meeting on neuroinflammation and will be the first to bring together the many communities of disease-focused neuroscientists and immunologists with an interest in the CNS.
Scholarship Deadline: September 30 2014
Discounted Abstract Deadline: September 30 2014
Abstract Deadline: October 23 2014
Discounted Registration Deadline: November 24 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Abide Therapeutics Inc.Educational donation provided by AmgenBiogen IdecFORUM Pharmaceuticals Inc.Shire Human Genetic TherapiesTakeda Pharmaceutical Company Limited
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

NeuroscientistNews
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS090833-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 25 | 4:00PM - 8:00PM
Arrival and Registration
Room: Sagebrush Lobby & Cantina


Sunday, January 25 | 6:00PM - 8:00PM
Welcome Mixer
Room: Sagebrush Lobby & Cantina
No registration fees are used to fund alcohol served at this function.

Monday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Sagebrush Lobby & Cantina


Monday, January 26 | 8:00AM - 9:00AM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 2 of 2
David M. Holtzman, Washington University, USA
Effects of ApoE on Abeta and tau Pathology: Where Might a Role for ApoE in Neuroinflammation Fit In?

Monday, January 26 | 8:00AM - 9:00AM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 2
* Richard M. Ransohoff, Third Rock Ventures, USA

Monday, January 26 | 9:00AM - 11:15AM
Neuroinflammation during Neurodevelopment
Room: Chamisa Ballroom 1

Speaker 5 of 5
E. Richard Stanley, Albert Einstein College of Medicine, USA
Short Talk: A Csf1r Haploinsufficient Mouse Model of Adult-Onset Leukodystrophy with Axonal Spheroids and Pigmented glia (ALSP)

Monday, January 26 | 9:00AM - 11:15AM
Neuroinflammation during Neurodevelopment
Room: Chamisa Ballroom 1

Speaker 4 of 5
Beth Stevens, Boston Children's Hospital, Harvard Medical School, USA
Immune Mechanisms of Synapse Loss in Health and Disease

Monday, January 26 | 9:00AM - 11:15AM
Neuroinflammation during Neurodevelopment
Room: Chamisa Ballroom 1

Speaker 3 of 5
Carla J. Shatz, Stanford University, USA
Developmental Critical Periods and Alzheimer's Disease – Can Knowledge of One Help Cure the Other?

Monday, January 26 | 9:00AM - 11:15AM
Neuroinflammation during Neurodevelopment
Room: Chamisa Ballroom 1

Speaker 2 of 5
Marc R. Freeman, Oregon Health & Science University, USA
TRAF4 Couples Draper to JNK and STAT Signaling to Activate Glia after Axonal Injury

Monday, January 26 | 9:00AM - 11:15AM
Neuroinflammation during Neurodevelopment
Room: Chamisa Ballroom 1

Speaker 1 of 5
* V. Hugh Perry, University of Southampton, UK

Monday, January 26 | 9:40AM - 10:00AM
Coffee Break
Room: Chamisa Lobby


Monday, January 26 | 11:15AM - 5:00PM
On Own for Lunch


Monday, January 26 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Monday, January 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Monday, January 26 | 2:30PM - 4:30PM
Workshop
Room: Chamisa Ballroom 1

Speaker 9 of 9
Taylor R. Jay, Case Western Reserve University, USA
Trem2 Deficiency Alters Monocyte Infiltration and Pathology in Mouse Models of Alzheimer’s Disease

Monday, January 26 | 2:30PM - 4:30PM
Workshop
Room: Chamisa Ballroom 1

Speaker 8 of 9
Christine L. Hsieh, University of California, San Francisco, USA
Single Cell RNA Sequencing Reveals Monocyte-Derived Macrophage Heterogeneity in TBI

Monday, January 26 | 2:30PM - 4:30PM
Workshop
Room: Chamisa Ballroom 1

Speaker 7 of 9
Claire L. Davies, Roslin Institute, University of Edinburgh, UK
A Murine Model of Self-Limiting Neuroinflammation Reveals a CCR2-Independent Mechanism of Inflammation Resolution

Monday, January 26 | 2:30PM - 4:30PM
Workshop
Room: Chamisa Ballroom 1

Speaker 6 of 9
Lily Keane, Bart's Cancer Institute, UK
Pathways Mediating the Increased Inflammatory Phenotype of Microglia from the Aging Brain

Monday, January 26 | 2:30PM - 4:30PM
Workshop
Room: Chamisa Ballroom 1

Speaker 5 of 9
Lawrence Fourgeaud, Janssen R&D, USA
TAM Receptor Regulation of Microglial Physiology

Monday, January 26 | 2:30PM - 4:30PM
Workshop
Room: Chamisa Ballroom 1

Speaker 4 of 9
Eva Czirr, Alkahest, USA
Microglial Complement Receptor 3 Is a Modulator of Abeta Degradation

Monday, January 26 | 2:30PM - 4:30PM
Workshop
Room: Chamisa Ballroom 1

Speaker 3 of 9
Lien Beckers, Catholic University of Leuven, Belgium
A Novel Chronic and Non-Phagocytic Activation State of Microglia Comprising mTOR Induction in Peroxisomal beta-Oxidation Deficiency

Monday, January 26 | 2:30PM - 4:30PM
Workshop
Room: Chamisa Ballroom 1

Speaker 2 of 9
Mark W. Albers, Massachusetts General Hospital, USA
Innate Immune Pattern Recognition Receptors Link Genomic Instability and Neurodegeneration

Monday, January 26 | 2:30PM - 4:30PM
Workshop
Room: Chamisa Ballroom 1

Speaker 1 of 9
* Christopher K. Glass, University of California, San Diego, USA

Monday, January 26 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Monday, January 26 | 5:00PM - 7:00PM
Neuroinflammatory Pathways of Host Defense
Room: Chamisa Ballroom 1

Speaker 1 of 5
* E. Richard Stanley, Albert Einstein College of Medicine, USA

Monday, January 26 | 5:00PM - 7:00PM
Neuroinflammatory Pathways of Host Defense
Room: Chamisa Ballroom 1

Speaker 2 of 5
Donald H. Gilden, University of Colorado Denver School of Medicine, USA
Varicella Zoster Virus Causes Giant Cell Arteritis

Monday, January 26 | 5:00PM - 7:00PM
Neuroinflammatory Pathways of Host Defense
Room: Chamisa Ballroom 1

Speaker 3 of 5
Glenn F. Rall, Fox Chase Cancer Center, USA
Neuropathogenesis as a Consequence of Peripheral Viral Infection

Monday, January 26 | 5:00PM - 7:00PM
Neuroinflammatory Pathways of Host Defense
Room: Chamisa Ballroom 1

Speaker 4 of 5
Robyn S. Klein, Washington University School of Medicine, USA
CNS Host Defense: Action at the BBB

Monday, January 26 | 5:00PM - 7:00PM
Neuroinflammatory Pathways of Host Defense
Room: Chamisa Ballroom 1

Speaker 5 of 5
Bevan Main, University of Melbourne, Australia
Short Talk: Targeting Interferon-alpha Receptor 1 (IFNAR1) Attenuates Nigral Degeneration in the MPTP Mouse Model of Parkinson’s Disease

Monday, January 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
No registration fees are used to fund alcohol served at this function.

Monday, January 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Tuesday, January 27 | 7:00AM - 8:00AM
Breakfast
Room: Sagebrush Lobby & Cantina


Tuesday, January 27 | 8:00AM - 11:00AM
Mononuclear Phagocytes in Neuroinflammation
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA

Tuesday, January 27 | 8:00AM - 11:00AM
Mononuclear Phagocytes in Neuroinflammation
Room: Chamisa Ballroom 1

Speaker 2 of 6
Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Investigating the Functions of Yolk-Sac Derived Tissue-Resident Macrophages

Tuesday, January 27 | 8:00AM - 11:00AM
Mononuclear Phagocytes in Neuroinflammation
Room: Chamisa Ballroom 1

Speaker 3 of 6
Marco Prinz, University of Freiburg, Germany
The Myeloid Side of the Brain

Tuesday, January 27 | 8:00AM - 11:00AM
Mononuclear Phagocytes in Neuroinflammation
Room: Chamisa Ballroom 1

Speaker 4 of 6
Marco Colonna, Washington University School of Medicine, USA
Lipid Sensing by TREM2 Sustains the Microglia Response to Amyloid-beta Deposition in an Alzheimer’s Disease Model

Tuesday, January 27 | 8:00AM - 11:00AM
Mononuclear Phagocytes in Neuroinflammation
Room: Chamisa Ballroom 1

Speaker 5 of 6
Christopher K. Glass, University of California, San Diego, USA
Enhancer Landscapes Specifying Microglia and Macrophage Identity and Function

Tuesday, January 27 | 8:00AM - 11:00AM
Mononuclear Phagocytes in Neuroinflammation
Room: Chamisa Ballroom 1

Speaker 6 of 6
Bahareh Ajami, Stanford University School of Medicine, USA
Short Talk: Single-Cell Immune Signatures Reveal Functional Heterogeneity in Myeloid Populations in Neuroinflammation and Neurodegeneration

Tuesday, January 27 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Tuesday, January 27 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Tuesday, January 27 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, January 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Tuesday, January 27 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Tuesday, January 27 | 5:00PM - 7:00PM
Neuroinflammation: BBB and Glial Cells
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Cheryl Wellington, University of British Columbia, Canada

Tuesday, January 27 | 5:00PM - 7:00PM
Neuroinflammation: BBB and Glial Cells
Room: Chamisa Ballroom 1

Speaker 2 of 5
Richard Daneman, University of California, San Diego, USA
The BBB: Cells and Signaling

Tuesday, January 27 | 5:00PM - 7:00PM
Neuroinflammation: BBB and Glial Cells
Room: Chamisa Ballroom 1

Speaker 3 of 5
Robert Bell, Pfizer Inc., USA
Targeting Blood-Brain Barrier Pathology for Treating CNS Disorders

Tuesday, January 27 | 5:00PM - 7:00PM
Neuroinflammation: BBB and Glial Cells
Room: Chamisa Ballroom 1

Speaker 4 of 5
Ryan J. Watts, Denali Therapeutics Inc, USA
BBB Disruption and Drug Delivery in Neurodegenerative Disease

Tuesday, January 27 | 5:00PM - 7:00PM
Neuroinflammation: BBB and Glial Cells
Room: Chamisa Ballroom 1

Speaker 5 of 5
Susanna Rosi, University of California, San Francisco, USA
Short Talk: The Impact of Aging on the Innate Immune Response to Traumatic Brain Injury

Tuesday, January 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
No registration fees are used to fund alcohol served at this function.

Tuesday, January 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Wednesday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Sagebrush Lobby & Cantina


Wednesday, January 28 | 8:00AM - 11:00AM
Neuroinflammation in Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Malu G. Tansey, University of Florida, USA

Wednesday, January 28 | 8:00AM - 11:00AM
Neuroinflammation in Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 2 of 5
Chris Gaiteri, Rush University Medical Center, USA
Ripples in Networks: Recreating Alzheimer's Expression and Endophenotypes Based on Causal Molecular Network Models of Microglia and Other Systems

Wednesday, January 28 | 8:00AM - 11:00AM
Neuroinflammation in Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 3 of 5
Cheryl Wellington, University of British Columbia, Canada
Inflammation after Traumatic Brain Injury: Challenges and Opportunities

Wednesday, January 28 | 8:00AM - 11:00AM
Neuroinflammation in Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 4 of 5
Robin Franklin, University of Cambridge, UK
Inflammation and Remyelination

Wednesday, January 28 | 8:00AM - 11:00AM
Neuroinflammation in Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 5 of 5
Soyon Hong, Boston Children's Hospital, USA
Short Talk: Classical Complement Cascade Mediates Early Synapse Loss in AD

Wednesday, January 28 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, January 28 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Wednesday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, January 28 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, January 28 | 5:00PM - 7:00PM
Innate Neuroinflammation: The Basics
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Beth Stevens, Boston Children's Hospital, Harvard Medical School, USA

Wednesday, January 28 | 5:00PM - 7:00PM
Innate Neuroinflammation: The Basics
Room: Chamisa Ballroom 1

Speaker 2 of 5
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs and their Roles in Neuroinflammation

Wednesday, January 28 | 5:00PM - 7:00PM
Innate Neuroinflammation: The Basics
Room: Chamisa Ballroom 1

Speaker 3 of 5
Eicke Latz, University of Bonn, Germany
Sensing the Environment – Role of Inflammasomes in Sterile Inflammatory Diseases

Wednesday, January 28 | 5:00PM - 7:00PM
Innate Neuroinflammation: The Basics
Room: Chamisa Ballroom 1

Speaker 4 of 5
Iain L. Campbell, University of Sydney, Australia
The IL-6/gp130 Family of Cytokines and the Astroglial/Microglial Nexus

Wednesday, January 28 | 5:00PM - 7:00PM
Innate Neuroinflammation: The Basics
Room: Chamisa Ballroom 1

Speaker 5 of 5
Pushpalatha Palle, Institute for Medical Microbiology, Immunology and Hygiene, Germany
Short Talk: Deciphering the Role of Combined Deficiencies of TLRs2,3,4,7,9 in the Mouse Model of Multiple Sclerosis

Wednesday, January 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
No registration fees are used to fund alcohol served at this function.

Wednesday, January 28 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa Ballroom 2


Thursday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Sagebrush Lobby & Cantina


Thursday, January 29 | 8:00AM - 11:00AM
Beyond Innate Neuroinflammation
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Tammy L. Kielian, University of Nebraska, USA

Thursday, January 29 | 8:00AM - 11:00AM
Beyond Innate Neuroinflammation
Room: Chamisa Ballroom 1

Speaker 2 of 6
Josep Dalmau, IDIBAPS/University of Barcelona and University of Pennsylvania, Spain
Antibody-Mediated Diseases of the CNS

Thursday, January 29 | 8:00AM - 11:00AM
Beyond Innate Neuroinflammation
Room: Chamisa Ballroom 1

Speaker 3 of 6
Oleg Butovsky, Harvard Medical School, USA
Identification of a Unique Molecular and Functional Microglia Signature in Health and Disease

Thursday, January 29 | 8:00AM - 11:00AM
Beyond Innate Neuroinflammation
Room: Chamisa Ballroom 1

Speaker 4 of 6
Makoto Inoue, Duke University Medical Center, USA
Intensive Stimulation of Innate Immunity Induces IFNbeta-Resistant EAE with Neural Retraction

Thursday, January 29 | 8:00AM - 11:00AM
Beyond Innate Neuroinflammation
Room: Chamisa Ballroom 1

Speaker 5 of 6
Hartmut Wekerle, Max Planck Institute, Germany
Sign Posts: CNS Phagocytes Presenting Myelin Autoantigen Guide Autoimmune T Cells into the Target Tissue

Thursday, January 29 | 8:00AM - 11:00AM
Beyond Innate Neuroinflammation
Room: Chamisa Ballroom 1

Speaker 6 of 6
Marion S. Buckwalter, Stanford Medical School, USA
Short Talk: B Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke

Thursday, January 29 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, January 29 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Foyer


Thursday, January 29 | 5:00PM - 7:00PM
Glial Cells in Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 1 of 4
V. Hugh Perry, University of Southampton, UK
Microglia Priming in Chronic Neurodegeneration: A Role for Systemic Inflammation

Thursday, January 29 | 5:00PM - 7:00PM
Glial Cells in Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 2 of 4
Richard M. Ransohoff, Third Rock Ventures, USA
Microglia Among the Myeloid Cells: Functions and their Regulation

Thursday, January 29 | 5:00PM - 7:00PM
Glial Cells in Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 3 of 4
Tammy L. Kielian, University of Nebraska, USA
Glial Dysfunction in Lysosomal Storage Disease

Thursday, January 29 | 5:00PM - 7:00PM
Glial Cells in Neurodegeneration
Room: Chamisa Ballroom 1

Speaker 4 of 4
Kathryn P. MacPherson, Emory University, USA
Short Talk: Inhibition of Soluble TNF Signaling with Systemic XPro1595 Modulates CNS and Peripheral Immune Cell Populations in 5xFAD Mice

Thursday, January 29 | 7:00PM - 7:30PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Ballroom 1


Thursday, January 29 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
No registration fees are used to fund alcohol served at this function.

Thursday, January 29 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 29 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Friday, January 30 | 10:25AM - 10:25AM
Departure


*Session Chair.