Web Desc
Autoimmunity and Tolerance
Organizer(s): Jane L. Grogan, Joanne L. Viney and Gerald T. Nepom
Date: February 03 - 08, 2015
Location: Keystone Resort, Keystone, CO, USA
Sponsored by AbbVie Inc., AstraZeneca, BioLegend, Inc., Genentech, Inc., NeoStem, Inc. and Novo Nordisk A/S
Summary of Meeting:
Understanding immune regulation in autoimmunity and tolerance is important for delivering therapies to patients with uncontrolled autoimmune disease. Therefore, the goal of this Keystone Symposia meeting is to bring together scientists and clinicians to discuss what we are learning from pre-clinical mouse models and patient studies. In this regard, the past decade has seen the translation of our fundamental understanding of the immune response into clinical studies, with some success and also some failures. These clinical outcomes, coupled with more sophisticated techniques available to interrogate the human immune response, allow us to reassess and further explore pathways that are driving autoimmune disease. In this symposium, we cover the pathways in immunity and tolerance that lead to loss of immunological control, dysregulated immune responses and chronic inflammatory disease. We cover preclinical and clinical aspects of a diverse number of autoimmune and inflammatory diseases including lupus, multiple sclerosis, inflammatory bowel disease, psoriasis, transplantation and rheumatoid arthritis. Each session is designed to include a basic research talk followed by a mechanistic talk on mouse and human and clinical translation.
Scholarship Deadline: October 2 2014
Discounted Abstract Deadline: October 2 2014
Abstract Deadline: November 4 2014
Discounted Registration Deadline: December 3 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AbbVie Inc.AstraZenecaBioLegend, Inc.Genentech, Inc.NeoStem, Inc.Novo Nordisk A/S
We gratefully acknowledge additional support for this conference from:
Biogen IdecOpsona Therapeutics Ltd
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Amgen Inc.

Biogen Idec

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
S. Karger A.G. - International Archives of Allergy and ImmunologyThe Journal of Rheumatology
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI114057-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 03 | 4:00PM - 8:00PM
Arrival and Registration
Room: Keystone Lodge Lobby


Tuesday, February 03 | 6:00PM - 8:00PM
Welcome Mixer
Room: Keystone Lodge-Bighorn Bar
No registration fees are used to fund alcohol served at this function.

Wednesday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Wednesday, February 04 | 8:00AM - 9:00AM
Keynote Address
Room: Grays Peak

Speaker 1 of 2
* Jane L. Grogan, Arsenal Biosciences, USA
Welcome Remarks and Introduction

Wednesday, February 04 | 8:00AM - 9:00AM
Keynote Address
Room: Grays Peak

Speaker 2 of 2
Maria Grazia Roncarolo, Stanford University School of Medicine, USA
New Strategies for T Cell Regulation: Lessons from the Clinic

Wednesday, February 04 | 9:00AM - 11:30AM
Balancing Immune Homeostasis with Effector and Regulatory T
Cells

Room: Grays Peak

Speaker 1 of 6
* Jane L. Grogan, Arsenal Biosciences, USA

Wednesday, February 04 | 9:00AM - 11:30AM
Balancing Immune Homeostasis with Effector and Regulatory T
Cells

Room: Grays Peak

Speaker 2 of 6
Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
War and Peace at the Mucosal Front Line: A T Cell's Perspective

Wednesday, February 04 | 9:00AM - 11:30AM
Balancing Immune Homeostasis with Effector and Regulatory T
Cells

Room: Grays Peak

Speaker 3 of 6
Andrea Itano, Evelo Biosciences, USA
The Balancing between Treg and Th17 Function: Targeting Pathways for Use in the Clinic

Wednesday, February 04 | 9:00AM - 11:30AM
Balancing Immune Homeostasis with Effector and Regulatory T
Cells

Room: Grays Peak

Speaker 4 of 6
Jane H. Buckner, Benaroya Research Institute at Virginia Mason, USA
Human T Cell Checkpoints in Autoimmune Disease

Wednesday, February 04 | 9:00AM - 11:30AM
Balancing Immune Homeostasis with Effector and Regulatory T
Cells

Room: Grays Peak

Speaker 5 of 6
Connor J. Dwyer, University of Miami Miller School of Medicine, USA
Short Talk: Expression of a Mutant Transgenic IL-2RBeta Subunit in NOD Mice to further Define the IL-2-Dependent Risk in T1D

Wednesday, February 04 | 9:00AM - 11:30AM
Balancing Immune Homeostasis with Effector and Regulatory T
Cells

Room: Grays Peak

Speaker 6 of 6
Iona S. Schuster, University of Western Australia, Australia
Short Talk: TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity

Wednesday, February 04 | 9:40AM - 10:00AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 04 | 11:30AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Wednesday, February 04 | 11:30AM - 5:00PM
On Own for Lunch


Wednesday, February 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 1: Breakthrough Innovations in Understanding Pathog
enesis of Disease
Room: Grays Peak

Speaker 1 of 9
* Jennifer L. Gommerman, University of Toronto, Canada

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 1: Breakthrough Innovations in Understanding Pathog
enesis of Disease
Room: Grays Peak

Speaker 2 of 9
* Joan Goverman, University of Washington, USA

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 1: Breakthrough Innovations in Understanding Pathog
enesis of Disease
Room: Grays Peak

Speaker 3 of 9
Jessica L. Harakal, University of Virginia, USA
Loss of Regulatory T Cells Leads to Th2-Mediated Murine Autoimmune Gastritis

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 1: Breakthrough Innovations in Understanding Pathog
enesis of Disease
Room: Grays Peak

Speaker 4 of 9
Eddie A. James, Benaroya Research Institute, USA
Recognition of Modified Epitopes in Human Autoimmune Disease

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 1: Breakthrough Innovations in Understanding Pathog
enesis of Disease
Room: Grays Peak

Speaker 5 of 9
Hui Jin, Osaka University, Japan
Cellular Misfolded Proteins Rescued from Protein Degradation by MHC Class II Molecules Are Targets for Autoantibodies in Autoimmune Diseases

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 1: Breakthrough Innovations in Understanding Pathog
enesis of Disease
Room: Grays Peak

Speaker 6 of 9
Noriko Komatsu, University of Tokyo, Japan
Pathogenic Conversion of Foxp3+ T Cells into TH17 Cells in Autoimmune Arthritis

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 1: Breakthrough Innovations in Understanding Pathog
enesis of Disease
Room: Grays Peak

Speaker 7 of 9
Melissa D. LaJevic, Stanford University, USA
Chemerin/CMKLR1 Are Required for Maximal Skin Disease in Experimental Psoriasis

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 1: Breakthrough Innovations in Understanding Pathog
enesis of Disease
Room: Grays Peak

Speaker 8 of 9
Dana E. Orange, Rockefeller University, USA
Rheumatoid Arthritis Patient T Cells Can Recognize Neutrophil NETs Presented by Dendritic Cells

Wednesday, February 04 | 2:30PM - 4:30PM
Workshop 1: Breakthrough Innovations in Understanding Pathog
enesis of Disease
Room: Grays Peak

Speaker 9 of 9
John E. Connolly, Parker Institute for Cancer Immunotherapy, USA
Dominant Immune Tolerance Is Characterized by Rapid Metabolic Reprograming

Wednesday, February 04 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 04 | 5:00PM - 7:15PM
Targeting Tolerogenic Pathways in Autoimmune Disease
Room: Grays Peak

Speaker 1 of 6
* Gerald T. Nepom, Benaroya Research Institute, USA

Wednesday, February 04 | 5:00PM - 7:15PM
Targeting Tolerogenic Pathways in Autoimmune Disease
Room: Grays Peak

Speaker 2 of 6
Joan Goverman, University of Washington, USA
How Different Effector T Cell Subsets Shape Inflammatory Pattern in Multiple Sclerosis

Wednesday, February 04 | 5:00PM - 7:15PM
Targeting Tolerogenic Pathways in Autoimmune Disease
Room: Grays Peak

Speaker 3 of 6
Jeffrey V. Ravetch, Rockefeller University, USA
Inhibitory Fc Receptors for IgG Maintain Peripheral Tolerance

Wednesday, February 04 | 5:00PM - 7:15PM
Targeting Tolerogenic Pathways in Autoimmune Disease
Room: Grays Peak

Speaker 4 of 6
David Klatzmann, Sorbonne University Medical School, France
Immunoregulation without Immunosuppression: The Promises of Low Dose IL2

Wednesday, February 04 | 5:00PM - 7:15PM
Targeting Tolerogenic Pathways in Autoimmune Disease
Room: Grays Peak

Speaker 5 of 6
Nathalie E. Blachère, Rockefeller University, USA
Short Talk: A New Mode of Tolerance Dictates Immune Responses to the Paraneoplastic Cerebellar Degeneration Antigen cdr2

Wednesday, February 04 | 5:00PM - 7:15PM
Targeting Tolerogenic Pathways in Autoimmune Disease
Room: Grays Peak

Speaker 6 of 6
Kenneth S. Tung, University of Virginia, USA
Short Talk: Sertoli Cell that Controls Testicular Barrier also Exports “Sequestered” Germ Cell Antigens to Maintain Regulatory T Cell-Dependent Systemic Tolerance

Wednesday, February 04 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Wednesday, February 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Thursday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Thursday, February 05 | 8:00AM - 11:15AM
Cytokine Governance of Tolerance and Inflammation
Room: Grays Peak

Speaker 1 of 7
* Joanne L. Viney, Pandion Therapeutics, USA

Thursday, February 05 | 8:00AM - 11:15AM
Cytokine Governance of Tolerance and Inflammation
Room: Grays Peak

Speaker 2 of 7
Daniel J. Cua, Janssen Pharmaceutical Companies of Johnson & Johnson, USA
Role of IL-17 in Multiple Immune Checkpoints in Preclinical Models

Thursday, February 05 | 8:00AM - 11:15AM
Cytokine Governance of Tolerance and Inflammation
Room: Grays Peak

Speaker 3 of 7
Jennifer E. Towne, Janssen Research & Development LLC, USA
Differential Roles for IL-23 and IL-17 in Intestinal Immunoregulation: Lessons Learned from Mouse and Man

Thursday, February 05 | 8:00AM - 11:15AM
Cytokine Governance of Tolerance and Inflammation
Room: Grays Peak

Speaker 4 of 7
Jennifer L. Gommerman, University of Toronto, Canada
Role of the TNFSF in Regulating Immune Responses in Murine Models

Thursday, February 05 | 8:00AM - 11:15AM
Cytokine Governance of Tolerance and Inflammation
Room: Grays Peak

Speaker 5 of 7
Frank Oliver Nestle, Sanofi, USA
Immune Sentinels and Pathogenesis in Psoriasis in the Clinic

Thursday, February 05 | 8:00AM - 11:15AM
Cytokine Governance of Tolerance and Inflammation
Room: Grays Peak

Speaker 6 of 7
Carlos A. Arbelaez, Amgen, USA
Short Talk: IL-7/IL-7R Signaling Differentially Affects Effector CD4+ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis

Thursday, February 05 | 8:00AM - 11:15AM
Cytokine Governance of Tolerance and Inflammation
Room: Grays Peak

Speaker 7 of 7
Ester Planas-Rigol, Universitat de Barcelona, Spain
Short Talk: IL-35: A New Cytokine Involved in Vascular Inflammation

Thursday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 05 | 11:15AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Thursday, February 05 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, February 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Thursday, February 05 | 2:30PM - 4:30PM
Workshop 2: Innovative Therapeutic Approaches for Treating D
isease
Room: Grays Peak

Speaker 1 of 10
* Maria Grazia Roncarolo, Stanford University School of Medicine, USA

Thursday, February 05 | 2:30PM - 4:30PM
Workshop 2: Innovative Therapeutic Approaches for Treating D
isease
Room: Grays Peak

Speaker 2 of 10
* David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA

Thursday, February 05 | 2:30PM - 4:30PM
Workshop 2: Innovative Therapeutic Approaches for Treating D
isease
Room: Grays Peak

Speaker 3 of 10
Jaya Prakash Chalise, Linköping University, Sweden
Interferon alpha-Induced Tolerance against Antigen-Induced Arthritis Is Mediated by Indoleamine 2, 3 Dioxygenase

Thursday, February 05 | 2:30PM - 4:30PM
Workshop 2: Innovative Therapeutic Approaches for Treating D
isease
Room: Grays Peak

Speaker 4 of 10
Paul L. Bollyky, Stanford University, USA
Inhibition of Hyaluronan Synthesis Restores Immune Tolerance during Autoimmune Insulitis

Thursday, February 05 | 2:30PM - 4:30PM
Workshop 2: Innovative Therapeutic Approaches for Treating D
isease
Room: Grays Peak

Speaker 5 of 10
Wanjun Chen, NIDCR, National Institutes of Health, USA
Generating Antigen-Specific Treg Cells in vivo to Treat Autoimmunity

Thursday, February 05 | 2:30PM - 4:30PM
Workshop 2: Innovative Therapeutic Approaches for Treating D
isease
Room: Grays Peak

Speaker 6 of 10
Anne S. De Groot, EpiVax, Inc., USA
Tregitopes Induce Natural and iTreg Activation and Expansion: A Fully Synthetic Alternative to IgT for Autoimmune Disease?

Thursday, February 05 | 2:30PM - 4:30PM
Workshop 2: Innovative Therapeutic Approaches for Treating D
isease
Room: Grays Peak

Speaker 7 of 10
Chie Hotta-Iwamura, National Institutes of Health, USA
DCIR2+ cDC2 Dendritic Cells and zbtb32 Expression Restore CD4 T Cell Tolerance and Inhibit Diabetes

Thursday, February 05 | 2:30PM - 4:30PM
Workshop 2: Innovative Therapeutic Approaches for Treating D
isease
Room: Grays Peak

Speaker 8 of 10
Chantal Kuhn, USA
Differential Role of APCs in Induction of Th3 Cells and Oral Tolerance

Thursday, February 05 | 2:30PM - 4:30PM
Workshop 2: Innovative Therapeutic Approaches for Treating D
isease
Room: Grays Peak

Speaker 9 of 10
Alex F. Pellerin, Biogen Idec, USA
Anti-BDCA2 Monoclonal Antibody Inhibits Plasmacytoid Dendritic Cell Activation through Fc-Dependent and Independent Mechanisms

Thursday, February 05 | 2:30PM - 4:30PM
Workshop 2: Innovative Therapeutic Approaches for Treating D
isease
Room: Grays Peak

Speaker 10 of 10
Natasha C. Ward, University of Miami Miller School of Medicine, USA
Selective Enhancement of Tregs and Tolerance by a Novel IL-2-Based Biologic

Thursday, February 05 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 05 | 5:00PM - 7:15PM
Contribution of Antigen-Presenting Cells to Immune Homeostas
is

Room: Grays Peak

Speaker 1 of 6
* Jennifer L. Gommerman, University of Toronto, Canada

Thursday, February 05 | 5:00PM - 7:15PM
Contribution of Antigen-Presenting Cells to Immune Homeostas
is

Room: Grays Peak

Speaker 2 of 6
Boris Reizis, New York University Langone Medical Center, USA
The Role of Dendritic Cells in Experimental Models of Lupus

Thursday, February 05 | 5:00PM - 7:15PM
Contribution of Antigen-Presenting Cells to Immune Homeostas
is

Room: Grays Peak

Speaker 3 of 6
Clara Abraham, Yale University, USA
Unexpected Mechanisms for Disease-Associated Genes in Macrophage Regulation

Thursday, February 05 | 5:00PM - 7:15PM
Contribution of Antigen-Presenting Cells to Immune Homeostas
is

Room: Grays Peak

Speaker 4 of 6
Joanne L. Viney, Pandion Therapeutics, USA
Modulating Plasmacytoid Dendritic Cell Function for Treating Autoimmune Disease

Thursday, February 05 | 5:00PM - 7:15PM
Contribution of Antigen-Presenting Cells to Immune Homeostas
is

Room: Grays Peak

Speaker 5 of 6
Bryan J. Vander Lugt, Genentech, Inc., USA
Short Talk: Programming of Immunoregulatory Properties in Migratory Dendritic Cells

Thursday, February 05 | 5:00PM - 7:15PM
Contribution of Antigen-Presenting Cells to Immune Homeostas
is

Room: Grays Peak

Speaker 6 of 6
Nathalie Cools, University of Antwerp, Belgium
Short Talk: Dendritic Cells in Multiple Sclerosis: Key Players in the Immune Pathogenesis, Key Players for New Cellular Immunotherapies

Thursday, February 05 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Thursday, February 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Shavano/Torreys


Friday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Friday, February 06 | 8:00AM - 11:15AM
Pathogenic and Regulatory B Cells in Autoimmune Disease
Room: Grays Peak

Speaker 1 of 7
* Carla V. Rothlin, Yale University, USA

Friday, February 06 | 8:00AM - 11:15AM
Pathogenic and Regulatory B Cells in Autoimmune Disease
Room: Grays Peak

Speaker 2 of 7
Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Role of B Cells, TLR and Type 1 IFNs in Murine Models of Lupus

Friday, February 06 | 8:00AM - 11:15AM
Pathogenic and Regulatory B Cells in Autoimmune Disease
Room: Grays Peak

Speaker 3 of 7
David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA
Altered B Cell Signaling Orchestrates Loss of Tolerance and Systemic Autoimmunity

Friday, February 06 | 8:00AM - 11:15AM
Pathogenic and Regulatory B Cells in Autoimmune Disease
Room: Grays Peak

Speaker 4 of 7
Thomas F. Tedder, Duke University Medical Center, USA
Antigen-Specific B10 Cells Negatively Regulate Autoimmunity

Friday, February 06 | 8:00AM - 11:15AM
Pathogenic and Regulatory B Cells in Autoimmune Disease
Room: Grays Peak

Speaker 5 of 7
Eoin McKinney, Cambridge University, UK
Tired of Relapsing: T Cell Exhaustion and Outcome in Autoimmune Disease

Friday, February 06 | 8:00AM - 11:15AM
Pathogenic and Regulatory B Cells in Autoimmune Disease
Room: Grays Peak

Speaker 6 of 7
Arya Biragyn, NIA, National Institutes of Health, USA
Short Talk: Regulatory Function of Cancer-Expanded MDSCs Requires Education from Cancer Bregs

Friday, February 06 | 8:00AM - 11:15AM
Pathogenic and Regulatory B Cells in Autoimmune Disease
Room: Grays Peak

Speaker 7 of 7
Kira V. Rubtsova, Eli Lilly and Company, USA
Short Talk: T-Bet Expressing B Cells Are Required for the Development of Autoimmunity

Friday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Friday, February 06 | 11:15AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Friday, February 06 | 11:15AM - 5:00PM
On Own for Lunch


Friday, February 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Friday, February 06 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Friday, February 06 | 5:00PM - 7:00PM
New Perspectives on Tolerance and Autoimmunity
Room: Grays Peak

Speaker 1 of 5
* Arlene H. Sharpe, Harvard Medical School, USA

Friday, February 06 | 5:00PM - 7:00PM
New Perspectives on Tolerance and Autoimmunity
Room: Grays Peak

Speaker 2 of 5
Carla V. Rothlin, Yale University, USA
TAM Receptor Tyrosine Kinases Regulate the Magnitude of the Immune Response

Friday, February 06 | 5:00PM - 7:00PM
New Perspectives on Tolerance and Autoimmunity
Room: Grays Peak

Speaker 3 of 5
Gerald T. Nepom, Benaroya Research Institute, USA
In Pursuit of Immune Tolerance

Friday, February 06 | 5:00PM - 7:00PM
New Perspectives on Tolerance and Autoimmunity
Room: Grays Peak

Speaker 4 of 5
Robert H. Scannevin, Biogen Idec, USA
Immunomodulatory Pathways for Therapeutic Intervention in Multiple Sclerosis

Friday, February 06 | 5:00PM - 7:00PM
New Perspectives on Tolerance and Autoimmunity
Room: Grays Peak

Speaker 5 of 5
Roberto A. Maldonado, Selecta Biosciences, USA
Short Talk: Tolerogenic Synthetic Nanoparticles for the Treatment of Autoimmune Diseases

Friday, February 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Friday, February 06 | 7:30PM - 10:00PM
Poster Session 3
Room: Shavano/Torreys


Saturday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Saturday, February 07 | 8:00AM - 11:15AM
Positive and Negative Co-Stimulatory Pathways in Tolerance a
nd Autoimmunity

Room: Grays Peak

Speaker 1 of 8
* Deborah J. Fowell, University of Rochester, USA

Saturday, February 07 | 8:00AM - 11:15AM
Positive and Negative Co-Stimulatory Pathways in Tolerance a
nd Autoimmunity

Room: Grays Peak

Speaker 2 of 8
* Thomas R. Malek, University of Miami School of Medicine, USA

Saturday, February 07 | 8:00AM - 11:15AM
Positive and Negative Co-Stimulatory Pathways in Tolerance a
nd Autoimmunity

Room: Grays Peak

Speaker 3 of 8
Arlene H. Sharpe, Harvard Medical School, USA
Control of T Follicular Regulatory Cells and Humoral Immunity by Co-Inhibitory Pathways

Saturday, February 07 | 8:00AM - 11:15AM
Positive and Negative Co-Stimulatory Pathways in Tolerance a
nd Autoimmunity

Room: Grays Peak

Speaker 4 of 8
John Trowsdale, University of Cambridge, UK
Modulation of T Cells by Butyrophilin-Related Proteins

Saturday, February 07 | 8:00AM - 11:15AM
Positive and Negative Co-Stimulatory Pathways in Tolerance a
nd Autoimmunity

Room: Grays Peak

Speaker 5 of 8
Jane L. Grogan, Arsenal Biosciences, USA
Inhibitory Receptor TIGIT Limits Anti-Viral and Anti-Tumor T Cell Responses


Saturday, February 07 | 8:00AM - 11:15AM
Positive and Negative Co-Stimulatory Pathways in Tolerance a
nd Autoimmunity

Room: Grays Peak

Speaker 6 of 8
Dwight H. Kono, The Scripps Research Institute, USA
The Impact of Genes and Signaling Pathways in Systemic Lupus

Saturday, February 07 | 8:00AM - 11:15AM
Positive and Negative Co-Stimulatory Pathways in Tolerance a
nd Autoimmunity

Room: Grays Peak

Speaker 7 of 8
Alexandria Huynh, Harvard Medical School/Massachusetts General Hospital, USA
Short Talk: PTEN-Mediated Control of PI-3 Kinase in Regulatory T Cells Is Required for Homeostasis and Lineage Stability

Saturday, February 07 | 8:00AM - 11:15AM
Positive and Negative Co-Stimulatory Pathways in Tolerance a
nd Autoimmunity

Room: Grays Peak

Speaker 8 of 8
Georgina Espigol-Frigole, Hospital Clinic Barcelona, Spain
Short Talk: Identification of IL-23p19 as an Endothelial Pro-Inflammatory Peptide that Activates gp130-STAT3 Signaling

Saturday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Saturday, February 07 | 11:15AM - 5:00PM
On Own for Lunch


Saturday, February 07 | 2:30PM - 4:30PM
Workshop 3: Novel in vitro and in vivo Models for Studying D
isease
Room: Grays Peak

Speaker 1 of 9
* Boris Reizis, New York University Langone Medical Center, USA

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 3: Novel in vitro and in vivo Models for Studying D
isease
Room: Grays Peak

Speaker 2 of 9
* Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 3: Novel in vitro and in vivo Models for Studying D
isease
Room: Grays Peak

Speaker 3 of 9
Marta E. Alarcón Riquelme, GENYO. Center for Genomics and Oncological Research, Spain
BANK1 Deficiency Ameliorates Lupus Phenotypes in B6.Sle1.yaa Mice

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 3: Novel in vitro and in vivo Models for Studying D
isease
Room: Grays Peak

Speaker 4 of 9
Wei Cao, UT MD Anderson Cancer Center, USA
Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon gamma Production from Natural Killer Cells

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 3: Novel in vitro and in vivo Models for Studying D
isease
Room: Grays Peak

Speaker 5 of 9
Oliver W. Gramlich, University of Iowa, USA
Adoptive Transfer of Immune Competent Cells Derived from a Glaucoma Mouse Model Causes Retinal Ganglion Cell Loss in Recipients

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 3: Novel in vitro and in vivo Models for Studying D
isease
Room: Grays Peak

Speaker 6 of 9
Pamela J. Lincez, University of British Columbia, Canada
MDA5 Establishes a Unique IFN-I Signature that Protects from T1D

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 3: Novel in vitro and in vivo Models for Studying D
isease
Room: Grays Peak

Speaker 7 of 9
Robin S. Lindsay, University of Virginia, USA
T Cell Stimulation in the Islets Is Lost as Islet Infiltration Progresses during Type 1 Diabetes

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 3: Novel in vitro and in vivo Models for Studying D
isease
Room: Grays Peak

Speaker 8 of 9
Genita Metzler, University of Washington, USA
The Effect of Autoimmune-Associated Ptpn22 R619W Variant on B Cell Tolerance in a Murine Model

Saturday, February 07 | 2:30PM - 4:30PM
Workshop 3: Novel in vitro and in vivo Models for Studying D
isease
Room: Grays Peak

Speaker 9 of 9
Anna-Marie Fairhurst, Singapore Immunology Network, Singapore
Elimination of the NLRP3 Inflammasome Prevents the Development of Lupus Associated Traits

Saturday, February 07 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Saturday, February 07 | 5:00PM - 6:45PM
Using Systems Biology to Interrogate Immune Regulation
Room: Grays Peak

Speaker 1 of 4
* Frank Oliver Nestle, Sanofi, USA

Saturday, February 07 | 5:00PM - 6:45PM
Using Systems Biology to Interrogate Immune Regulation
Room: Grays Peak

Speaker 2 of 4
Chris Cotsapas, Yale School of Medicine, USA
Talk Title to be Announced

Saturday, February 07 | 5:00PM - 6:45PM
Using Systems Biology to Interrogate Immune Regulation
Room: Grays Peak

Speaker 3 of 4
Alan Aderem, Center for Infectious Disease Research, USA
A Systems Approach to Dissecting Immunity

Saturday, February 07 | 5:00PM - 6:45PM
Using Systems Biology to Interrogate Immune Regulation
Room: Grays Peak

Speaker 4 of 4
Chun Ye, University of California, San Francisco, USA
Intersection of Population Variation and Autoimmunity Genetics in Human T Cell Activation

Saturday, February 07 | 6:45PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Grays Peak

Speaker 1 of 3
Jane L. Grogan, Arsenal Biosciences, USA

Saturday, February 07 | 6:45PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Grays Peak

Speaker 2 of 3
Joanne L. Viney, Pandion Therapeutics, USA

Saturday, February 07 | 6:45PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions
Room: Grays Peak

Speaker 3 of 3
Gerald T. Nepom, Benaroya Research Institute, USA

Saturday, February 07 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Saturday, February 07 | 8:00PM - 11:00PM
Entertainment
Room: Shavano/Torreys
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Saturday, February 07 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Sunday, February 08 | 10:25AM - 10:25AM
Departure


*Session Chair.