Web Desc
Systems Biology of Lipid Metabolism
Organizer(s): Matej Orešic, Antonio J. Vidal-Puig and Ana Maria Cuervo
Date: February 09 - 13, 2015
Location: Beaver Run Resort, Breckenridge, CO, USA
Sponsored by Abide Therapeutics Inc.
Summary of Meeting:
Lipid homeostasis is fundamental to the maintenance of good health. Due to the enormous functional and structural diversity of lipids as well as their complex regulation at multiple spatial and temporal scales, lipids need to be studied not only at the level of biological pathways but also at the level of the biophysical systems they are part of, including cellular membranes or lipoprotein particles. From the perspective of systems biology, this adds an additional but necessary layer of complexity to the studies of lipids. This Keystone Symposia meeting will cover recent progress and perspectives in the studies of lipids as related to: 1) Cellular as well as systemic lipid metabolism; 2) Computational modeling of lipids; and 3) The role of lipids in the pathogenesis of several complex diseases including metabolic, immune and central nervous system disorders as well as cancer. Specifically, experts in this area will address whether alterations in lipid biology may be an important underlying pathogenic link among these disorders, which could explain the well documented metabolic co-morbidities such as between obesity and several other complex diseases. The meeting will bring together a highly interdisciplinary and outstanding group of scientists including biochemists, molecular and cellular biologists, clinical researchers and computational biologists. Such a diverse mix will facilitate the cross-disciplinary interactions needed to address current key questions in lipid biology in the context of translational medicine, as well as move the field of lipids forward by consolidating the use of systems biology approaches to study their involvement in the pathogenesis of common diseases.
Scholarship Deadline: October 14 2014
Discounted Abstract Deadline: October 14 2014
Abstract Deadline: November 13 2014
Discounted Registration Deadline: December 10 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Abide Therapeutics Inc.
We gratefully acknowledge additional support for this conference from:
Avanti Polar Lipids, Inc.Mabtech Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Eli Lilly and Company
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK104458-01
Funding for this conference was made possible (in part) by 1 R13 DK104458-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, February 09 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Monday, February 09 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Tuesday, February 10 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Tuesday, February 10 | 8:00AM - 8:15AM
Welcome Remarks

Speaker 1 of 3
Matej Orešic, Steno Diabetes Center, Denmark

Tuesday, February 10 | 8:00AM - 8:15AM
Welcome Remarks

Speaker 2 of 3
Antonio J. Vidal-Puig, University of Cambridge, UK

Tuesday, February 10 | 8:00AM - 8:15AM
Welcome Remarks

Speaker 3 of 3
Ana Maria Cuervo, Albert Einstein College of Medicine, USA

Tuesday, February 10 | 8:15AM - 9:15AM
Keynote Address
Room: Peaks 4-5

Speaker 1 of 1
Dennis E. Vance, University of Alberta, Canada
What Is the Mechanism by which Lack of Phosphatidylethanolamine N-Methyltransferase Protects Mice from Obesity and Insulin Resistance?

Tuesday, February 10 | 9:15AM - 11:45AM
Cellular Lipid Signaling and Metabolism
Room: Peaks 4-5
This session aims to cover some of the recent progress in the studies of lipids in the context of specific cellular processes.
Speaker 1 of 6
* Almut Schulze, University of Würzburg/Theodor-Boveri Institute, Germany

Tuesday, February 10 | 9:15AM - 11:45AM
Cellular Lipid Signaling and Metabolism
Room: Peaks 4-5
This session aims to cover some of the recent progress in the studies of lipids in the context of specific cellular processes.
Speaker 2 of 6
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Interplay between Selective Autophagy and Lipid Metabolism

Tuesday, February 10 | 9:15AM - 11:45AM
Cellular Lipid Signaling and Metabolism
Room: Peaks 4-5
This session aims to cover some of the recent progress in the studies of lipids in the context of specific cellular processes.
Speaker 3 of 6
Eyleen J. O'Rourke, University of Virginia, USA
Deconstructing the C. elegans Metabomap

Tuesday, February 10 | 9:15AM - 11:45AM
Cellular Lipid Signaling and Metabolism
Room: Peaks 4-5
This session aims to cover some of the recent progress in the studies of lipids in the context of specific cellular processes.
Speaker 4 of 6
Neha Chauhan, Weill Cornell Medical College, USA
Greasing the Cell Cycle: Identification of the Morphogenesis Checkpoint Kinase Swe1 as a Lipolysis-Dependent Cell Cycle Regulator

Tuesday, February 10 | 9:15AM - 11:45AM
Cellular Lipid Signaling and Metabolism
Room: Peaks 4-5
This session aims to cover some of the recent progress in the studies of lipids in the context of specific cellular processes.
Speaker 5 of 6
Rona Aviram, Weizmann Institute of Science, Israel
Short Talk: Around the Clock Lipidomics: Insight into Circadian Oscillations of Lipids in Subcellular Compartments

Tuesday, February 10 | 9:15AM - 11:45AM
Cellular Lipid Signaling and Metabolism
Room: Peaks 4-5
This session aims to cover some of the recent progress in the studies of lipids in the context of specific cellular processes.
Speaker 6 of 6
Jurre J. Kamphorst, Rheos Medicines, USA
Short Talk: Hypoxia Induces Fatty Acid Metabolic Changes in Cancer Cells

Tuesday, February 10 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer


Tuesday, February 10 | 11:45AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Tuesday, February 10 | 11:45AM - 5:00PM
On Own for Lunch


Tuesday, February 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Tuesday, February 10 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, February 10 | 5:00PM - 7:00PM
Modeling of Lipid Metabolism
Room: Peaks 4-5
This session focuses on computational modeling approaches to study different levels of lipid metabolism, with applications.
Speaker 1 of 5
* Michael J.O. Wakelam, Babraham Institute, UK

Tuesday, February 10 | 5:00PM - 7:00PM
Modeling of Lipid Metabolism
Room: Peaks 4-5
This session focuses on computational modeling approaches to study different levels of lipid metabolism, with applications.
Speaker 2 of 5
Jens Nielsen, Chalmers University of Technology, Sweden
Integrative Analysis of Lipid Metabolism through Genome-Scale Modeling of Metabolism

Tuesday, February 10 | 5:00PM - 7:00PM
Modeling of Lipid Metabolism
Room: Peaks 4-5
This session focuses on computational modeling approaches to study different levels of lipid metabolism, with applications.
Speaker 3 of 5
Ilpo Vattulainen, Tampere University of Technology, Finland
Molecular Simulations of Lipid Membranes, Lipid-Protein Interactions and Lipoproteins

Tuesday, February 10 | 5:00PM - 7:00PM
Modeling of Lipid Metabolism
Room: Peaks 4-5
This session focuses on computational modeling approaches to study different levels of lipid metabolism, with applications.
Speaker 4 of 5
Matej Orešic, Steno Diabetes Center, Denmark
Lipid Pathways Behind the Acquired Obesity and the Associated Co-Morbidities

Tuesday, February 10 | 5:00PM - 7:00PM
Modeling of Lipid Metabolism
Room: Peaks 4-5
This session focuses on computational modeling approaches to study different levels of lipid metabolism, with applications.
Speaker 5 of 5
Natal A. van Riel, Eindhoven University of Technology, Netherlands
Short Talk: A Systems Biology Approach Reveals the Physiological Origin of Increased Plasma HDL Levels and Hepatic Steatosis Induced by Liver X Receptor Activation

Tuesday, February 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3
No registration fees are used to fund alcohol served at this function.

Tuesday, February 10 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 1-3


Wednesday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Wednesday, February 11 | 8:00AM - 11:00AM
Lipids in Obesity and its Metabolic Co-Morbidities
Room: Peaks 4-5
This session covers studies on the role of lipids in obesity and developments of its metabolic complications.
Speaker 1 of 6
* Matej Orešic, Steno Diabetes Center, Denmark

Wednesday, February 11 | 8:00AM - 11:00AM
Lipids in Obesity and its Metabolic Co-Morbidities
Room: Peaks 4-5
This session covers studies on the role of lipids in obesity and developments of its metabolic complications.
Speaker 2 of 6
Antonio J. Vidal-Puig, University of Cambridge, UK
Adipose Tissue Expandability, Lipotoxicity and the Metabolic Syndrome

Wednesday, February 11 | 8:00AM - 11:00AM
Lipids in Obesity and its Metabolic Co-Morbidities
Room: Peaks 4-5
This session covers studies on the role of lipids in obesity and developments of its metabolic complications.
Speaker 3 of 6
Elizabeth J. Parks, University of Missouri, USA
Fatty Acid Metabolism in Obesity and Fatty Liver

Wednesday, February 11 | 8:00AM - 11:00AM
Lipids in Obesity and its Metabolic Co-Morbidities
Room: Peaks 4-5
This session covers studies on the role of lipids in obesity and developments of its metabolic complications.
Speaker 4 of 6
Rudolf Zechner, University of Graz, Austria
Lipolyis in Health and Disease

Wednesday, February 11 | 8:00AM - 11:00AM
Lipids in Obesity and its Metabolic Co-Morbidities
Room: Peaks 4-5
This session covers studies on the role of lipids in obesity and developments of its metabolic complications.
Speaker 5 of 6
David E. Moller, Eli Lilly and Company, USA
Novel Drug Targets - Modulating Fatty Acid Metabolism as a Therapeutic Approach for Metabolic Disorders

Wednesday, February 11 | 8:00AM - 11:00AM
Lipids in Obesity and its Metabolic Co-Morbidities
Room: Peaks 4-5
This session covers studies on the role of lipids in obesity and developments of its metabolic complications.
Speaker 6 of 6
Kelli M. Sas, University of Michigan, USA
Short Talk: Increased beta-Oxidation and Mitochondrial Dysfunction in Diabetic Nephropathy

Wednesday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, February 11 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Wednesday, February 11 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, February 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Wednesday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, February 11 | 5:00PM - 7:00PM
Lipids in Immune System Regulation
Room: Peaks 4-5
This session covers studies of lipids on the interface of metabolism and the immune system.
Speaker 1 of 5
* Antonio J. Vidal-Puig, University of Cambridge, UK

Wednesday, February 11 | 5:00PM - 7:00PM
Lipids in Immune System Regulation
Room: Peaks 4-5
This session covers studies of lipids on the interface of metabolism and the immune system.
Speaker 2 of 5
Anthony W. Ferrante, Columbia University, USA
Immune Regulation of Lipid Metabolism

Wednesday, February 11 | 5:00PM - 7:00PM
Lipids in Immune System Regulation
Room: Peaks 4-5
This session covers studies of lipids on the interface of metabolism and the immune system.
Speaker 3 of 5
Marielle Koeberlin, CeMM Research Center for Molecular Medicine, Austria
Short Talk: Functional Mapping of the Lipid Landscape in Innate Immunity

Wednesday, February 11 | 5:00PM - 7:00PM
Lipids in Immune System Regulation
Room: Peaks 4-5
This session covers studies of lipids on the interface of metabolism and the immune system.
Speaker 4 of 5
Valerie B. O'Donnell, Cardiff University, UK
Discovery and characterization of new lipids generated by immune cells using mass spectrometry

Wednesday, February 11 | 5:00PM - 7:00PM
Lipids in Immune System Regulation
Room: Peaks 4-5
This session covers studies of lipids on the interface of metabolism and the immune system.
Speaker 5 of 5
Tuulia Hyötyläinen, Novo Nordisk/Steno Diabetes Center, Denmark
Altered Lipid Metabolism Preceding Onset of Islet Autoimmunity and Type 1 Diabetes

Wednesday, February 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3
No registration fees are used to fund alcohol served at this function.

Wednesday, February 11 | 7:30PM - 10:00PM
Poster Session 2
Room: Peaks 1-3


Thursday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Summit Gallery


Thursday, February 12 | 8:00AM - 11:15AM
Lipid Metabolism and the Brain
Room: Peaks 4-5
This session covers recent progress in studies of lipids in the context of brain metabolism including in CNS and metabolic disease.
Speaker 1 of 7
* Ana Maria Cuervo, Albert Einstein College of Medicine, USA

Thursday, February 12 | 8:00AM - 11:15AM
Lipid Metabolism and the Brain
Room: Peaks 4-5
This session covers recent progress in studies of lipids in the context of brain metabolism including in CNS and metabolic disease.
Speaker 2 of 7
Cheryl Wellington, University of British Columbia, Canada
HDL Metabolism in the Brain

Thursday, February 12 | 8:00AM - 11:15AM
Lipid Metabolism and the Brain
Room: Peaks 4-5
This session covers recent progress in studies of lipids in the context of brain metabolism including in CNS and metabolic disease.
Speaker 3 of 7
Satchidananda Panda, The Salk Institute for Biological Studies, USA
Eating Pattern in Circadian Regulation of Lipid Metabolism

Thursday, February 12 | 8:00AM - 11:15AM
Lipid Metabolism and the Brain
Room: Peaks 4-5
This session covers recent progress in studies of lipids in the context of brain metabolism including in CNS and metabolic disease.
Speaker 4 of 7
Xianlin Han, Sanford Burnham Medical Research Institute, USA
Lipidomics Approaches to Study Alzheimer's Disease

Thursday, February 12 | 8:00AM - 11:15AM
Lipid Metabolism and the Brain
Room: Peaks 4-5
This session covers recent progress in studies of lipids in the context of brain metabolism including in CNS and metabolic disease.
Speaker 5 of 7
Karl Fernandes, University of Montreal, Canada
Short Talk: Aberrant Fatty Acid Metabolism at the Brain-CSF Barrier in Alzheimer’s Disease

Thursday, February 12 | 8:00AM - 11:15AM
Lipid Metabolism and the Brain
Room: Peaks 4-5
This session covers recent progress in studies of lipids in the context of brain metabolism including in CNS and metabolic disease.
Speaker 6 of 7
Paul Amminger, University of Melbourne, Australia
Polyunsaturated Fatty Acids in Emerging Psychotic Disorders

Thursday, February 12 | 8:00AM - 11:15AM
Lipid Metabolism and the Brain
Room: Peaks 4-5
This session covers recent progress in studies of lipids in the context of brain metabolism including in CNS and metabolic disease.
Speaker 7 of 7
Dale D.O. Martin, University of British Columbia, Canada
Short Talk: Assembly of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System

Thursday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, February 12 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, February 12 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, February 12 | 5:00PM - 6:45PM
Lipids in Cancer
Room: Peaks 4-5
This session overviews the progress in the study of cancer as a co-morbidity of obesity, with specific focus on lipids as an underlying link.
Speaker 1 of 4
* Jurre J. Kamphorst, Rheos Medicines, USA

Thursday, February 12 | 5:00PM - 6:45PM
Lipids in Cancer
Room: Peaks 4-5
This session overviews the progress in the study of cancer as a co-morbidity of obesity, with specific focus on lipids as an underlying link.
Speaker 2 of 4
Raffaella M. Gadaleta, University of Bari, Italy
Bile Acids and Cancer: The Role of FXR

Thursday, February 12 | 5:00PM - 6:45PM
Lipids in Cancer
Room: Peaks 4-5
This session overviews the progress in the study of cancer as a co-morbidity of obesity, with specific focus on lipids as an underlying link.
Speaker 3 of 4
Michael J.O. Wakelam, Babraham Institute, UK
Lipidomic Analysis of Tumor Cells and Tissues

Thursday, February 12 | 5:00PM - 6:45PM
Lipids in Cancer
Room: Peaks 4-5
This session overviews the progress in the study of cancer as a co-morbidity of obesity, with specific focus on lipids as an underlying link.
Speaker 4 of 4
Almut Schulze, University of Würzburg/Theodor-Boveri Institute, Germany
Metabolic Reprogramming in Cancer Supports Cell Growth and Survival

Thursday, February 12 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Peaks 4-5


Thursday, February 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3
No registration fees are used to fund alcohol served at this function.

Thursday, February 12 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 1-3
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, February 12 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 1-3


Friday, February 13 | 10:25AM - 10:25AM
Departure


*Session Chair.