Web Desc
Biology of Sirtuins
Organizer(s): Raul Mostoslavsky, Shin-ichiro Imai, Marcia C. Haigis, Eric M. Verdin
Date: March 08 - 12, 2015
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Supported by the Directors' Fund
For important information on the coronavirus, please click here
Summary of Meeting:
The biology of sirtuins, a unique class of NAD+-dependent enzymes that modify diverse protein substrates, has rapidly emerged in the past decade as regulators of critical biological processes, and the field will further evolve into many interdisciplinary areas of biomedical science in coming years. Furthermore, sirtuins are now clearly recognized as important targets for preventive and therapeutic interventions against a wide variety of diseases. Therefore, this second Keystone Symposia meeting on sirtuin biology will particularly focus on integrative aspects of diverse sirtuin functions, featuring eight interdisciplinary sessions and one workshop. Because there is an increasing enthusiasm for sirtuin biology across the globe, it is critical to provide such a forum where the significance of the “integrative biology of sirtuins” can be fully discussed and interdisciplinary interactions will be stimulated among people from many different fields.
Scholarship Deadline: November 6 2014
Discounted Abstract Deadline: November 6 2014
Abstract Deadline: December 9 2014
Discounted Registration Deadline: January 8 2015
Abstacts when book is in proofing process


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

DAIICHI SANKYO CO., LTD.

GlaxoSmithKline
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1R13AG049581-01
Funding for this conference was made possible, in part by Grant # 1R13AG049581-01 from the National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 08 | 4:00PM - 8:00PM
Arrival and Registration
Room: Promenade


Sunday, March 08 | 6:00PM - 8:00PM
Welcome Mixer
Room: Promenade
No registration fees are used to fund alcohol served at this function.

Monday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Monday, March 09 | 8:00AM - 9:00AM
Keynote Address
Room: Mesa A-B

Speaker 1 of 1
John M. Denu, University of Wisconsin-Madison, USA
Life and Times in the Sirtuin Field

Monday, March 09 | 9:00AM - 11:30AM
Sirtuins in Metabolism and Signaling Pathways
Room: Mesa A-B

Speaker 1 of 5
David B. Lombard, University of Michigan, USA
Roles for the Sirtuin SIRT5 in Tumor Metabolism

Monday, March 09 | 9:00AM - 11:30AM
Sirtuins in Metabolism and Signaling Pathways
Room: Mesa A-B

Speaker 2 of 5
Stephen L. Helfand, Brown University, USA
Sirtuins in the Fly: Effect on Mitochondria, Gene Regulation and Chromatin Maintenance Controls Metabolism and Longevity

Monday, March 09 | 9:00AM - 11:30AM
Sirtuins in Metabolism and Signaling Pathways
Room: Mesa A-B

Speaker 3 of 5
* Shin-ichiro Imai, Washington University School of Medicine, USA
The NAD World Reloaded: The Importance of the Inter-Tissue Communication Mediated by NAMPT/NAD+/SIRT1 in Mammalian Aging/Longevity Control

Monday, March 09 | 9:00AM - 11:30AM
Sirtuins in Metabolism and Signaling Pathways
Room: Mesa A-B

Speaker 4 of 5
Charles Brenner, University of Iowa, USA
Short Talk: How Nicotinamide Riboside Promotes Weight Loss

Monday, March 09 | 9:00AM - 11:30AM
Sirtuins in Metabolism and Signaling Pathways
Room: Mesa A-B

Speaker 5 of 5
Joseph A. Garcia, Columbia University Medical Center, USA
Short Talk: An Acetate Switch Links Dynamic Changes in Intermediary Metabolism with Stress Signaling in Mammals

Monday, March 09 | 9:40AM - 10:00AM
Coffee Break
Room: Promenade


Monday, March 09 | 11:30AM - 1:00PM
Poster Setup
Room: Mesa C


Monday, March 09 | 11:30AM - 5:00PM
On Own for Lunch


Monday, March 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Mesa C


Monday, March 09 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Monday, March 09 | 5:00PM - 7:15PM
Biochemistry and Structure of Sirtuins
Room: Mesa A-B

Speaker 1 of 6
* John M. Denu, University of Wisconsin-Madison, USA

Monday, March 09 | 5:00PM - 7:15PM
Biochemistry and Structure of Sirtuins
Room: Mesa A-B

Speaker 2 of 6
Anthony A. Sauve, Weill Cornell Medical College, USA
Studies of Sirtuin Mechanism and Function Using Chemical Tools

Monday, March 09 | 5:00PM - 7:15PM
Biochemistry and Structure of Sirtuins
Room: Mesa A-B

Speaker 3 of 6
David A. Sinclair, Harvard Medical School, USA
Evidence for an Epigenetic Cause of Aging and Age-Related Diseases

Monday, March 09 | 5:00PM - 7:15PM
Biochemistry and Structure of Sirtuins
Room: Mesa A-B

Speaker 4 of 6
Hening Lin, Cornell University, USA
Sirtuin Inhibitors as Anticancer Agents

Monday, March 09 | 5:00PM - 7:15PM
Biochemistry and Structure of Sirtuins
Room: Mesa A-B

Speaker 5 of 6
Clemens Steegborn, University of Bayreuth, Germany
Short Talk: Novel Substrates and Inhibitors for Sirtuins 4 and 5 through Structural, Biochemical and Mass Spectrometry Studies

Monday, March 09 | 5:00PM - 7:15PM
Biochemistry and Structure of Sirtuins
Room: Mesa A-B

Speaker 6 of 6
Lulu A. Cambronne, Oregon Health & Sciences University, USA
Short Talk: A Genetically-Encoded Fluorescent NAD+ Sensor

Monday, March 09 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa/Ortiz
No registration fees are used to fund alcohol served at this function.

Monday, March 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Mesa C


Tuesday, March 10 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Tuesday, March 10 | 7:30AM - 8:00AM
Poster Setup
Room: Mesa C


Tuesday, March 10 | 8:00AM - 5:00PM
Poster Viewing
Room: Mesa C


Tuesday, March 10 | 8:00AM - 11:15AM
Sirtuins and Cancer
Room: Mesa A-B

Speaker 1 of 7
* Raul Mostoslavsky, Harvard Medical School, USA
Linking Epigenetics, Metabolism and Cancer: SIRT6 Provides Some Clues

Tuesday, March 10 | 8:00AM - 11:15AM
Sirtuins and Cancer
Room: Mesa A-B

Speaker 2 of 7
Michael Ristow, Swiss Federal Institute of Technology Zurich - ETH, Switzerland
Mitohormesis: How Reactive Oxygen Species (ROS) Promote Healthspan

Tuesday, March 10 | 8:00AM - 11:15AM
Sirtuins and Cancer
Room: Mesa A-B

Speaker 3 of 7
Marcia C. Haigis, Harvard Medical School, USA
New Roles for Sirtuins in Mitochondrial Homeostasis

Tuesday, March 10 | 8:00AM - 11:15AM
Sirtuins and Cancer
Room: Mesa A-B

Speaker 4 of 7
David Gius, Northwestern University Feinberg School of Medical, USA
Short Talk: Loss of SIRT3 Activity and MnSOD Acetylation Results in Endocrine Breast Tumor Cell Resistance

Tuesday, March 10 | 8:00AM - 11:15AM
Sirtuins and Cancer
Room: Mesa A-B

Speaker 5 of 7
Berta N. Vazquez, Rutgers University, USA
Short Talk: SIRT7 Promotes Genome Integrity by Regulating Non-Homologous End Joining DNA Repair

Tuesday, March 10 | 8:00AM - 11:15AM
Sirtuins and Cancer
Room: Mesa A-B

Speaker 6 of 7
Marty W. Mayo, University of Virginia, USA
Short Talk: NAD+-Dependent Deacetylases SIRT1 and SIRT2 Regulate the Mitogen-Activated Protein Kinase Kinase (MEK)-1 Alternative Pathway

Tuesday, March 10 | 8:00AM - 11:15AM
Sirtuins and Cancer
Room: Mesa A-B

Speaker 7 of 7
Christina M. Ferrer, Drexel University College of Medicine, USA
Short Talk: O-GlcNAcylation Regulates Breast Cancer Cell Invasion via the NAD+-Dependent Deacetylase SIRT1

Tuesday, March 10 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Tuesday, March 10 | 11:15AM - 12:00PM
Lunch
Room: Chamisa/Ortiz


Tuesday, March 10 | 12:00PM - 2:30PM
Poster Session 2
Room: Mesa C


Tuesday, March 10 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Sirtuin Biology
Room: Mesa A-B

Speaker 1 of 8
* David A. Sinclair, Harvard Medical School, USA

Tuesday, March 10 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Sirtuin Biology
Room: Mesa A-B

Speaker 2 of 8
Matthew D. Hirschey, Duke University, USA
Chemical Reactivity and Novel Post-Translational Modifications Regulated by Mitochondrial Sirtuins

Tuesday, March 10 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Sirtuin Biology
Room: Mesa A-B

Speaker 3 of 8
Zhen Tong, Cornell University, USA
SIRT7 Regulates the Activation of RALA via Defatty-Acylation

Tuesday, March 10 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Sirtuin Biology
Room: Mesa A-B

Speaker 4 of 8
Natalie E. de Picciotto, University of Colorado Boulder, USA
SIRT1 Activation with Nicotinamide Mononucleotide Improves Vascular Function in Old Male Mice

Tuesday, March 10 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Sirtuin Biology
Room: Mesa A-B

Speaker 5 of 8
Mark Y. Jeng, University of California, San Francisco, USA
Loss of SIRT1 Mediates Metabolic Reprogramming in Memory T Cells during Aging and Chronic Infections

Tuesday, March 10 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Sirtuin Biology
Room: Mesa A-B

Speaker 6 of 8
Pavlos Pissios, NGM Bio, USA
Nicotinamide N-Methyltransferase Regulates Hepatic Nutrient Metabolism through N1-Methylnicotinamide

Tuesday, March 10 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Sirtuin Biology
Room: Mesa A-B

Speaker 7 of 8
X. Charlie Dong, Indiana University School of Medicine, USA
Sirt6 Regulates Insulin Secretion from the Pancreatic Beta Cells

Tuesday, March 10 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Sirtuin Biology
Room: Mesa A-B

Speaker 8 of 8
Alison Ringel, Harvard Medical School, USA
Alternate Deacylating Specificities for the Archaeal Sirtuins Sir2Af1 and Sir2Af2

Tuesday, March 10 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Tuesday, March 10 | 5:00PM - 7:15PM
Sirtuins and Mitochondrial Biology
Room: Mesa A-B

Speaker 1 of 4
* Eric M. Verdin, Buck Institute for Research on Aging, USA
SIRT1, CD4 T Cell Subsets and Autoimmunity

Tuesday, March 10 | 5:00PM - 7:15PM
Sirtuins and Mitochondrial Biology
Room: Mesa A-B

Speaker 2 of 4
Brian K. Kennedy, National University of Singapore, Singapore
Sirtuins and mTOR as Modulators of Metabolic Responses

Tuesday, March 10 | 5:00PM - 7:15PM
Sirtuins and Mitochondrial Biology
Room: Mesa A-B

Speaker 3 of 4
Hiroshi Itoh, Keio University School of Medicine, Japan
Sirt1 Function in Kidney

Tuesday, March 10 | 5:00PM - 7:15PM
Sirtuins and Mitochondrial Biology
Room: Mesa A-B

Speaker 4 of 4
Joseph T. Bass, Northwestern University, USA
Circadian Rhythms in Mitochondrial Function

Tuesday, March 10 | 7:15PM - 7:15PM
On Own for Dinner


Wednesday, March 11 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa/Ortiz


Wednesday, March 11 | 8:00AM - 11:00AM
Sirtuins, Neurobiology and Neurodegeneration
Room: Mesa A-B

Speaker 1 of 6
Leonard P. Guarente, Massachusetts Institute of Technology, USA
Sirtuins, NAD and Aging

Wednesday, March 11 | 8:00AM - 11:00AM
Sirtuins, Neurobiology and Neurodegeneration
Room: Mesa A-B

Speaker 2 of 6
* Ruth Luthi-Carter, University of Leicester, UK
Sirtuins as Therapeutic Targets Against Neurodegeneration

Wednesday, March 11 | 8:00AM - 11:00AM
Sirtuins, Neurobiology and Neurodegeneration
Room: Mesa A-B

Speaker 3 of 6
Katrin F. Chua, Stanford University Medical Center, USA
Chromatin Regulation and Genome Maintenance by Mammalian SIRT6 and SIRT7

Wednesday, March 11 | 8:00AM - 11:00AM
Sirtuins, Neurobiology and Neurodegeneration
Room: Mesa A-B

Speaker 4 of 6
Lindsey B. Gano, University of Colorado, Anschutz Medical Campus, USA
Short Talk: SIRT3 Dysfunction in Experimental Temporal Lobe Epilepsy

Wednesday, March 11 | 8:00AM - 11:00AM
Sirtuins, Neurobiology and Neurodegeneration
Room: Mesa A-B

Speaker 5 of 6
Tatyana Gudz, Medical University of South Carolina, USA
Short Talk: SIRT3-Mediated Deacetylation of Ceramide Synthase Promotes Mitochondrial Dysfunction and Brain Injury after Stroke

Wednesday, March 11 | 8:00AM - 11:00AM
Sirtuins, Neurobiology and Neurodegeneration
Room: Mesa A-B

Speaker 6 of 6
Colleen A. Stoyas, University of California, San Diego, USA
Short Talk: Does Sirt1 Dysregulation Contribute to Pathogenesis of the Neurodegenerative Disorder Spinocerebellar Ataxia Type 7?

Wednesday, March 11 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Wednesday, March 11 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, March 11 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Wednesday, March 11 | 5:00PM - 7:30PM
Sirtuins as Targets for Therapeutic Purposes
Room: Mesa A-B

Speaker 1 of 6
* Marcia C. Haigis, Harvard Medical School, USA

Wednesday, March 11 | 5:00PM - 7:30PM
Sirtuins as Targets for Therapeutic Purposes
Room: Mesa A-B

Speaker 2 of 6
James L. Ellis, GlaxoSmithKline, USA
Sirtuin Modulators as Therapeutic Agents for Metabolic and Inflammatory Diseases

Wednesday, March 11 | 5:00PM - 7:30PM
Sirtuins as Targets for Therapeutic Purposes
Room: Mesa A-B

Speaker 3 of 6
Eriko Michishita-Kioi, Daiichi Sankyo Co., Ltd., Japan
Targeting Metabolic Enzymes

Wednesday, March 11 | 5:00PM - 7:30PM
Sirtuins as Targets for Therapeutic Purposes
Room: Mesa A-B

Speaker 4 of 6
Yousin Suh, Albert Einstein College of Medicine, USA
Molecular Mechanisms Underlying SIRT1 Disease Risk Variants

Wednesday, March 11 | 5:00PM - 7:30PM
Sirtuins as Targets for Therapeutic Purposes
Room: Mesa A-B

Speaker 5 of 6
Xiaoling Li, NIEHS, National Institutes of Health, USA
SIRT1 in Metabolism, Tissue Homeostasis and Human Diseases

Wednesday, March 11 | 5:00PM - 7:30PM
Sirtuins as Targets for Therapeutic Purposes
Room: Mesa A-B

Speaker 6 of 6
Manfred Jung, University of Freiburg, Germany
Short Talk: Selective Inhibition of the NAD-Dependent Histone Deacetylase hSirt2 by Ligand-Induced Rearrangement of the Active Site

Wednesday, March 11 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Promenade/Mesa Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, March 11 | 8:00PM - 11:00PM
Entertainment
Room: Mesa Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Wednesday, March 11 | 9:00PM - 11:00PM
Cash Bar
Room: Mesa Ballroom


Thursday, March 12 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.