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Web Desc
Optogenetics Organizer(s): Edward S. Boyden, Klaus M. Hahn and Chandra Tucker Date: March 12 - 16, 2015 Location: Westin Downtown Denver, Denver, CO, USA Supported by the Directors' Fund Summary of Meeting: The complexity of biological systems demands tools that enable temporally and spatially precise control of defined signaling pathways. Optogenetics is a new and rapidly evolving field that combines light control with genetic engineering, allowing conditional regulation of signaling processes with seconds and microns precision. Using optogenetic probes, the functions of specific molecules and pathways, the behaviors of individual cells, and the interactions of groups of cells in complex organisms can be precisely interrogated. This symposium seeks to bring together a broad range of researchers developing and using optogenetic probes with those developing related technologies. Specific goals include: 1) To present the latest innovative, genetically-encoded tools and technologies for manipulating biological systems with light; 2) To promote exchange between those developing light-responsive probes and developers of related tools (e.g., biosensors, hardware) that will maximize the power of optogenetics; and 3) To foster the exchange of ideas between optogenetic tool developers and users. This bi-directional feedback has occurred in the neurosciences but not more broadly across biology. No other meeting focuses on these three topics in quite this way. This meeting should facilitate the development and dissemination of a diversity of new optical tools, bring together a diverse but synergistic group of innovators and experimentalists, and ultimately open up new experimental avenues for study that will transform diverse fields. Scholarship Deadline: November 12 2014 Discounted Abstract Deadline: November 12 2014 Abstract Deadline: December 11 2014 Discounted Registration Deadline: January 13 2015 We gratefully acknowledge additional support for this conference from: Intelligent Imaging Innovations (3i) We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Neurological Disorders and Stroke (NINDS) Grant No. 1R13NS090878-01 The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Optogenetics

Organizer(s): Edward S. Boyden, Klaus M. Hahn and Chandra Tucker

Date: March 12 - 16, 2015
Location: Westin Downtown Denver, Denver, CO, USA

Supported by the Directors' Fund

Summary of Meeting:

The complexity of biological systems demands tools that enable temporally and spatially precise control of defined signaling pathways. Optogenetics is a new and rapidly evolving field that combines light control with genetic engineering, allowing conditional regulation of signaling processes with seconds and microns precision. Using optogenetic probes, the functions of specific molecules and pathways, the behaviors of individual cells, and the interactions of groups of cells in complex organisms can be precisely interrogated. This symposium seeks to bring together a broad range of researchers developing and using optogenetic probes with those developing related technologies. Specific goals include: 1) To present the latest innovative, genetically-encoded tools and technologies for manipulating biological systems with light; 2) To promote exchange between those developing light-responsive probes and developers of related tools (e.g., biosensors, hardware) that will maximize the power of optogenetics; and 3) To foster the exchange of ideas between optogenetic tool developers and users. This bi-directional feedback has occurred in the neurosciences but not more broadly across biology. No other meeting focuses on these three topics in quite this way. This meeting should facilitate the development and dissemination of a diversity of new optical tools, bring together a diverse but synergistic group of innovators and experimentalists, and ultimately open up new experimental avenues for study that will transform diverse fields.

Scholarship Deadline: November 12 2014

Discounted Abstract Deadline: November 12 2014

Abstract Deadline: December 11 2014

Discounted Registration Deadline: January 13 2015

We gratefully acknowledge additional support for this conference from:

Intelligent Imaging Innovations (3i)

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS090878-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Thursday, March 12 \| 4:00PM - 8:00PM Arrival and Registration Room: Conference Office C
Thursday, March 12 \| 6:00PM - 8:00PM Welcome Mixer Room: V Lounge No registration fees are used to fund alcohol served at this function.
Friday, March 13 \| 7:30AM - 8:30AM Breakfast Room: Augusta
Friday, March 13 \| 8:30AM - 9:30AM Keynote Address Room: Platte River Room Speaker 1 of 1 Roger Y. Tsien, HHMI/University of California, San Diego, USA Molecules for Red Light Activation or for Long-Term Memory Storage
Friday, March 13 \| 9:30AM - 11:45AM Optogenetic Engineering I Room: Platte River Room Speaker 1 of 5 * Peter Hegemann, Humboldt-Universität zu Berlin, Germany
Friday, March 13 \| 9:30AM - 11:45AM Optogenetic Engineering I Room: Platte River Room Speaker 2 of 5 Klaus M. Hahn, University of North Carolina at Chapel Hill, USA Engineering Proteins for Control and Visualization of Signaling Networks in vivo
Friday, March 13 \| 9:30AM - 11:45AM Optogenetic Engineering I Room: Platte River Room Speaker 3 of 5 Michael Z. Lin, Stanford University School of Medicine, USA Optogenetics Reunified: Fluorescent Proteins in Optical Sensing of Membrane Voltage and Optical Control of Protein Activity
Friday, March 13 \| 9:30AM - 11:45AM Optogenetic Engineering I Room: Platte River Room Speaker 4 of 5 Ehud Isacoff, University of California, Berkeley, USA Optical Control of Glutamate Receptor Signaling: Spatio-Temporal Gating of Synaptic Plasticity
Friday, March 13 \| 9:30AM - 11:45AM Optogenetic Engineering I Room: Platte River Room Speaker 5 of 5 Ajith Karunarathne, University of Toledo, USA Short Talk: Subcellular Optogenetics: Optical Control of Subcellular Signaling and Cell Behavior
Friday, March 13 \| 10:10AM - 10:30AM Coffee Break Room: Platte River Foyer
Friday, March 13 \| 11:45AM - 1:00PM Poster Setup Room: Augusta
Friday, March 13 \| 11:45AM - 5:00PM On Own for Lunch
Friday, March 13 \| 1:00PM - 10:00PM Poster Viewing Room: Augusta
Friday, March 13 \| 4:30PM - 5:00PM Coffee Available Room: Augusta
Friday, March 13 \| 5:00PM - 7:00PM Structural and Genomic Diversity of Photoreceptor Proteins Room: Platte River Foyer Speaker 1 of 5 * Kevin H. Gardner, CUNY Advanced Science Research Center, USA
Friday, March 13 \| 5:00PM - 7:00PM Structural and Genomic Diversity of Photoreceptor Proteins Room: Platte River Foyer Speaker 2 of 5 Peter Hegemann, Humboldt-Universität zu Berlin, Germany Second-Generation Light-Activated Chloride Channels
Friday, March 13 \| 5:00PM - 7:00PM Structural and Genomic Diversity of Photoreceptor Proteins Room: Platte River Foyer Speaker 3 of 5 J. Keith Moffat, University of Chicago, USA Photoreceptor Control at the Atomic Level
Friday, March 13 \| 5:00PM - 7:00PM Structural and Genomic Diversity of Photoreceptor Proteins Room: Platte River Foyer Speaker 4 of 5 Gane Ka-Shu Wong, University of Alberta, Canada 1000 Plants: Mining Biodiversity for Optogenetics
Friday, March 13 \| 5:00PM - 7:00PM Structural and Genomic Diversity of Photoreceptor Proteins Room: Platte River Foyer Speaker 5 of 5 Udo Heintz, Max Planck Institute for Medical Research, Germany Short Talk: Blue Light-Induced Dimerization of Aureochrome1a-LOV Enhances the Affinity for its Target DNA Sequence - Crystal Structures Offer New Design Strategies for Optogenetics
Friday, March 13 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Augusta No registration fees are used to fund alcohol served at this function.
Friday, March 13 \| 7:30PM - 10:00PM Poster Session 1 Room: Augusta No registration fees are used to fund alcohol served at this function.
Saturday, March 14 \| 7:30AM - 8:30AM Breakfast Room: Augusta
Saturday, March 14 \| 7:30AM - 8:00AM Poster Setup Room: Augusta
Saturday, March 14 \| 8:00AM - 5:00PM Poster Viewing Room: Augusta
Saturday, March 14 \| 8:30AM - 11:45AM Optogenetic Engineering II Room: Platte River Room Speaker 1 of 7 * Klaus M. Hahn, University of North Carolina at Chapel Hill, USA
Saturday, March 14 \| 8:30AM - 11:45AM Optogenetic Engineering II Room: Platte River Room Speaker 2 of 7 Edward S. Boyden, Massachusetts Institute of Technology, USA Tools for Mapping and Engineering the Brain
Saturday, March 14 \| 8:30AM - 11:45AM Optogenetic Engineering II Room: Platte River Room Speaker 3 of 7 Chandra Tucker, University of Colorado Denver, USA New Cryptochrome Tools for Optical Control
Saturday, March 14 \| 8:30AM - 11:45AM Optogenetic Engineering II Room: Platte River Room Speaker 4 of 7 Masayuki Yazawa, Columbia University, USA Short Talk: Improvement and Applications of FKF1/GI-Based System to Induce Protein-Protein Interactions Using Blue Light
Saturday, March 14 \| 8:30AM - 11:45AM Optogenetic Engineering II Room: Platte River Room Speaker 5 of 7 Steven G. Boxer, Stanford University, USA Light-Directed Dissociation and Association of Split GFP
Saturday, March 14 \| 8:30AM - 11:45AM Optogenetic Engineering II Room: Platte River Room Speaker 6 of 7 Andreas Moglich, Humboldt-Universität zu Berlin, Germany Engineering Light-Responsive Proteins
Saturday, March 14 \| 8:30AM - 11:45AM Optogenetic Engineering II Room: Platte River Room Speaker 7 of 7 Anastasia Fomicheva, University of Wyoming, USA Short Talk: Engineering Near-Infrared Light-Activated Orthologous Drug Systems
Saturday, March 14 \| 9:50AM - 10:10AM Coffee Break Room: Platte River Foyer
Saturday, March 14 \| 11:45AM - 12:30PM Lunch Room: Augusta
Saturday, March 14 \| 12:30PM - 2:30PM Poster Session 2 Room: Augusta
Saturday, March 14 \| 4:30PM - 5:00PM Coffee Available Room: Platte River Foyer
Saturday, March 14 \| 5:00PM - 7:00PM Optical Control of Biological Processes I Room: Platte River Room Speaker 1 of 5 * Denise J. Montell, University of California, Santa Barbara, USA
Saturday, March 14 \| 5:00PM - 7:00PM Optical Control of Biological Processes I Room: Platte River Room Speaker 2 of 5 Mathieu Coppey, Institut Curie, France Spatiotemporal Manipulation of Optogenetic Probes
Saturday, March 14 \| 5:00PM - 7:00PM Optical Control of Biological Processes I Room: Platte River Room Speaker 3 of 5 Matthew J. Kennedy, University of Colorado Denver, USA Tools for Controlling Neuronal Cell Biology with Light
Saturday, March 14 \| 5:00PM - 7:00PM Optical Control of Biological Processes I Room: Platte River Room Speaker 4 of 5 Jared Toettcher, Princeton University, USA Using Optogenetics to Dissect Information Processing in Ras/MAPK Signaling
Saturday, March 14 \| 5:00PM - 7:00PM Optical Control of Biological Processes I Room: Platte River Room Speaker 5 of 5 Kristen Lee Witte, University of Chicago, USA Short Talk: Optogenetic Control of Symmetry Breaking in Saccharomyces cerevisiae
Saturday, March 14 \| 7:00PM - 7:00PM On Own for Dinner
Sunday, March 15 \| 7:30AM - 8:30AM Breakfast Room: Augusta
Sunday, March 15 \| 8:30AM - 11:45AM Optical Control of Biological Processes II Room: Platte River Room Speaker 1 of 7 * Chandra Tucker, University of Colorado Denver, USA
Sunday, March 15 \| 8:30AM - 11:45AM Optical Control of Biological Processes II Room: Platte River Room Speaker 2 of 7 Denise J. Montell, University of California, Santa Barbara, USA Genetics and Optogenetics Reveal Multiple Distinct Roles for E-cadherin in Coordinating Collective Cell Migration in vivo
Sunday, March 15 \| 8:30AM - 11:45AM Optical Control of Biological Processes II Room: Platte River Room Speaker 3 of 7 Kevin H. Gardner, CUNY Advanced Science Research Center, USA Nature’s Switches, Biologists’ Tools: Use of LOV Domains to Control Cellular Activities
Sunday, March 15 \| 8:30AM - 11:45AM Optical Control of Biological Processes II Room: Platte River Room Speaker 4 of 7 Keren Lasker, Stanford University, USA Short Talk: Using Optically Reversible Spatial Mutations to Dissect the Asymmetric Developmental Program of a Bacterium
Sunday, March 15 \| 8:30AM - 11:45AM Optical Control of Biological Processes II Room: Platte River Room Speaker 5 of 7 Brian Kuhlman, University of North Carolina at Chapel Hill, USA Engineering Improved Switches for Light-Induced Dimerization and Light-Conditioned Nuclear Translocation
Sunday, March 15 \| 8:30AM - 11:45AM Optical Control of Biological Processes II Room: Platte River Room Speaker 6 of 7 Viviana Gradinaru, California Institute of Technology, USA Visualizing the Activity and Anatomy of Brain Circuits: Optogenetic Sensors and Tissue-Clearing Approaches
Sunday, March 15 \| 8:30AM - 11:45AM Optical Control of Biological Processes II Room: Platte River Room Speaker 7 of 7 Spencer T. Glantz, University of Pennsylvania, USA Short Talk: Comprehensive Analysis of the Functional Diversity of LOV Domain Proteins
Sunday, March 15 \| 9:50AM - 10:10AM Coffee Break Room: Platte River Foyer
Sunday, March 15 \| 11:45AM - 5:00PM On Own for Lunch
Sunday, March 15 \| 4:30PM - 5:00PM Coffee Available Room: Platte River Foyer
Sunday, March 15 \| 5:00PM - 7:00PM Optical Control of Biological Processes III Room: Platte River Room Speaker 1 of 6 * Edward S. Boyden, Massachusetts Institute of Technology, USA
Sunday, March 15 \| 5:00PM - 7:00PM Optical Control of Biological Processes III Room: Platte River Room Speaker 2 of 6 Valentina Emiliani, Paris Descartes University, France Optogenetics and Wave Front Shaping
Sunday, March 15 \| 5:00PM - 7:00PM Optical Control of Biological Processes III Room: Platte River Room Speaker 3 of 6 Xue Han, Boston University, USA Technologies for Analyzing Neural Circuits of Brain Disorders
Sunday, March 15 \| 5:00PM - 7:00PM Optical Control of Biological Processes III Room: Platte River Room Speaker 4 of 6 Ariel E. Hight, Harvard University, USA Short Talk: Spatially Restricted Optogenetic Stimulation of the Central Auditory System in an Auditory Brainstem Implant Model
Sunday, March 15 \| 5:00PM - 7:00PM Optical Control of Biological Processes III Room: Platte River Room Speaker 5 of 6 Seung-Hee Lee, Korea Advanced Institutes of Science and Technology, KAIST, South Korea Short Talk: Virtual Perception Induced by Optogenetic Stimulation of Mouse Sensory Cortices
Sunday, March 15 \| 5:00PM - 7:00PM Optical Control of Biological Processes III Room: Platte River Room Speaker 6 of 6 Emil B. Kromann, Yale University, USA Short Talk: Optogenetics Meets Nanoscale Fluorescence Imaging
Sunday, March 15 \| 7:00PM - 7:15PM Meeting Wrap-Up: Outcomes and Future Directions (Organizers) Room: Platte River Room
Sunday, March 15 \| 7:15PM - 8:30PM Social Hour with Lite Bites Room: Augusta No registration fees are used to fund alcohol served at this function.
Sunday, March 15 \| 8:00PM - 11:00PM Entertainment Room: Augusta Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Sunday, March 15 \| 8:00PM - 11:00PM Cash Bar Room: Augusta
Monday, March 16 \| 10:25AM - 10:25AM Departure *Session Chair.