Web Desc
Co-Infection: A Global Challenge for Disease Control
Organizer(s): Rodrigo Corrêa-Oliveira, David Dunne and Andrea Graham
Date: March 15 - 20, 2015
Location: Centro de Artes e Convenções (UFOP), Ouro Preto, MG, Brazil
Organized in collaboration with the Minas Gerais State Agency for Research Development (FAPEMIG). Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
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Summary of Meeting:
Multi-species co-infections pose one of the greatest challenges to global health and to our efforts to develop effective methods of infectious disease control. Populations living in rural areas of many low-income countries are exposed to both chronic and acute infection with multiple pathogens. In such conditions, co-infection is common and the cause of additive or synergistic morbidities. Studying co-infections is difficult and complex as different pathogens may interact in many different ways, either directly or via the host immune response. Indeed, in some contexts, a community of organisms within a host may promote defense against other organisms. This Keystone Symposia meeting will focus on our current understanding of synergism/antagonism among pathogens causing common co-infections. In doing so it will bring together leading researchers and their knowledge of immune responses in co-infected individuals, co-infection immunoepidemiology, modeling of co-infections to predict disease and infection outcomes, and the specific challenges that co-infection presents to vaccine design strategies, and effective application of chemotherapy. This diversity of scientific disciplines will together address the impacts of co-infection, particularly in the context of the Neglected Tropical Diseases that are prevalent in many low- and middle-income countries. For example, in some of the poorest parts of the world, HIV, TB, leprosy, HTLV, malaria, dengue and chronic helminth infections are co-endemic. To improve understanding and the means to effectively tackle the diverse clinical and public health problems of co-infection, we need to combine information derived from basic hypothesis-led research, descriptive epidemiology and new computational modeling techniques. The goal of this symposium is to broaden and deepen our understanding of within-host and population-level interactions between different co-infecting pathogens and propose appropriate multidisciplinary strategies to move toward clinical and public health solutions, including the delivery of effective vaccination and chemotherapy.
Global Health Travel Award Deadline: October 14 2014
Scholarship Deadline: November 17 2014
Discounted Abstract Deadline: November 17 2014
Abstract Deadline: December 16 2014
Discounted Registration Deadline: January 14 2015
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates FoundationMinas Gerais State Agency for Research Development (FAPEMIG) - Brazil
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
PLOS
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI115998-01
Funding for this conference was made possible (in part) by 1 R13 AI 115998 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 15 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Sunday, March 15 | 6:00PM - 8:00PM
Welcome Mixer
Room: Sabara
No registration fees are used to fund alcohol served at this function.

Monday, March 16 | 7:30AM - 8:30AM
Breakfast
Room: Own Hotel


Monday, March 16 | 8:30AM - 9:30AM
Keynote Address
Room: São João de Rel

Speaker 1 of 2
* Rodrigo Corrêa-Oliveira, FIOCRUZ, Brazil

Monday, March 16 | 8:30AM - 9:30AM
Keynote Address
Room: São João de Rel

Speaker 2 of 2
Thomas B. Nutman, NIAID, National Institutes of Health, USA
Bystander Efects of Tissue Invasive Helminths on Mycobacterial and Other Infectious Diseases of Humans

Monday, March 16 | 9:30AM - 12:00PM
Co-Infection by Intracellular Pathogens I
Room: São João de Rel

Speaker 1 of 6
* Shona Wilson, University of Cambridge, UK

Monday, March 16 | 9:30AM - 12:00PM
Co-Infection by Intracellular Pathogens I
Room: São João de Rel

Speaker 2 of 6
Rodrigo Corrêa-Oliveira, FIOCRUZ, Brazil
The Effect of Helminth Co-Infections on the Outcome of the Immune Response to Schistosoma mansoni

Monday, March 16 | 9:30AM - 12:00PM
Co-Infection by Intracellular Pathogens I
Room: São João de Rel

Speaker 3 of 6
Lena Serghides, University Health Network, Canada
Innate Immune Responses to Malaria in the Context of HIV Co-Infection

Monday, March 16 | 9:30AM - 12:00PM
Co-Infection by Intracellular Pathogens I
Room: São João de Rel

Speaker 4 of 6
Bruno B. Andrade, Fundação Oswaldo Cruz, Brazil
Profiling the Monocyte Inflammatory Responses in Tuberculosis-Associated IRIS

Monday, March 16 | 9:30AM - 12:00PM
Co-Infection by Intracellular Pathogens I
Room: São João de Rel

Speaker 5 of 6
Teck Hui Teo, Singapore Immunology Network, Singapore
Short Talk: Co-Infection with Chikungunya Virus Alters Pathogenic Host Response and Prevents Experimental Cerebral Malaria

Monday, March 16 | 9:30AM - 12:00PM
Co-Infection by Intracellular Pathogens I
Room: São João de Rel

Speaker 6 of 6
Caline G. Matar, Vertex Pharmaceuticals, USA
Short Talk: Gammaherpesvirus Co-Infection Promotes Malaria Lethality by Impairing the Generation of Anti-Parasitic Humoral Immunity

Monday, March 16 | 9:50AM - 10:10AM
Coffee Break
Room: Sabara


Monday, March 16 | 12:00PM - 1:00PM
Poster Setup
Room: Tiradentes


Monday, March 16 | 12:00PM - 5:00PM
On Own for Lunch


Monday, March 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Tiradentes


Monday, March 16 | 4:30PM - 5:00PM
Coffee Available
Room: Sabara


Monday, March 16 | 5:00PM - 7:00PM
Co-Infection by Intracellular Pathogens II
Room: São João de Rel

Speaker 1 of 5
* Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands

Monday, March 16 | 5:00PM - 7:00PM
Co-Infection by Intracellular Pathogens II
Room: São João de Rel

Speaker 2 of 5
Richard K. Grencis, University of Manchester, UK
Chronic Gastrointestinal Nematode Infection: The Interplay between Microflora, Host Immunity and Trichuris

Monday, March 16 | 5:00PM - 7:00PM
Co-Infection by Intracellular Pathogens II
Room: São João de Rel

Speaker 3 of 5
Vinicius Martins de Menezes, Universidade Federal do Estado do Rio de Janeiro, Brazil
Leprosy Type 1 Reaction in HIV Co-Infected Patients

Monday, March 16 | 5:00PM - 7:00PM
Co-Infection by Intracellular Pathogens II
Room: São João de Rel

Speaker 4 of 5
Ann M. Moormann, University of Massachusetts Medical School, USA
Malaria and EBV Co-Infections in the Etiology of Endemic Burkitt Lymphoma

Monday, March 16 | 5:00PM - 7:00PM
Co-Infection by Intracellular Pathogens II
Room: São João de Rel

Speaker 5 of 5
Jacqueline M. Leung, Princeton University, USA
Short Talk: The Effects of Anthelmintic Treatment on the Incidence and Severity of Diarrheal Disease

Monday, March 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Tiradentes


Monday, March 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Tiradentes


Tuesday, March 17 | 7:30AM - 8:30AM
Breakfast
Room: Own Hotel


Tuesday, March 17 | 8:30AM - 5:00PM
Additional poster viewing of Poster Session 1
Room: Tiradentes


Tuesday, March 17 | 8:30AM - 11:45AM
Helminth Co-Infection and its Impact on Intracellular Pathog
ens

Room: São João de Rel

Speaker 1 of 6
* Donald A. Harn, University of Georgia College of Veterinary Medicine, USA

Tuesday, March 17 | 8:30AM - 11:45AM
Helminth Co-Infection and its Impact on Intracellular Pathog
ens

Room: São João de Rel

Speaker 2 of 6
Henry J. McSorley, Queen's Medical Research Institute, UK
Intestinal Helminth Infection, Innate Immunity and the Anti-Viral State

Tuesday, March 17 | 8:30AM - 11:45AM
Helminth Co-Infection and its Impact on Intracellular Pathog
ens

Room: São João de Rel

Speaker 3 of 6
Frank Brombacher, International Center for Genetic Engineering and Biotechnology, South Africa
Immune Responses in Helminth and Bacterial Co-Infections

Tuesday, March 17 | 8:30AM - 11:45AM
Helminth Co-Infection and its Impact on Intracellular Pathog
ens

Room: São João de Rel

Speaker 4 of 6
Eyrun F. Kjetland, Oslo University Hospital, Norway
S. haematobium and HIV Interactions Affecting Odds of Transmission in Zimbabwe

Tuesday, March 17 | 8:30AM - 11:45AM
Helminth Co-Infection and its Impact on Intracellular Pathog
ens

Room: São João de Rel

Speaker 5 of 6
Norman Nausch, University Hospital Duesseldorf, Germany
Short Talk: The Influence of Mansonella Perstans Co-Infection on the Anti-Mycobacterial Immune Response in Children with Buruli Ulcer or Tuberculosis

Tuesday, March 17 | 8:30AM - 11:45AM
Helminth Co-Infection and its Impact on Intracellular Pathog
ens

Room: São João de Rel

Speaker 6 of 6
Clarissa Prazeres da Costa, Institute for Medical Microbiology, Immunology and Hygiene, Germany
Maternal Immune Response to Helminth Infection during Pregnancy Determines Offspring Susceptibility to Allergic Airway Inflammation

Tuesday, March 17 | 9:50AM - 10:10AM
Coffee Break
Room: Sabara


Tuesday, March 17 | 11:30AM - 5:00PM
On Own for Lunch


Tuesday, March 17 | 4:30PM - 5:00PM
Coffee Available
Room: Sabara


Tuesday, March 17 | 5:00PM - 7:00PM
Immunological Effects of Parasite Co-Infections in Disease-E
ndemic Areas

Room: São João de Rel

Speaker 1 of 5
* Frank Brombacher, International Center for Genetic Engineering and Biotechnology, South Africa

Tuesday, March 17 | 5:00PM - 7:00PM
Immunological Effects of Parasite Co-Infections in Disease-E
ndemic Areas

Room: São João de Rel

Speaker 2 of 5
Edgar M. Carvalho, Universidade Federal da Bahia, Brazil
Clinical and Immunologic Features of the Association between Tuberculosis and Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Infection

Tuesday, March 17 | 5:00PM - 7:00PM
Immunological Effects of Parasite Co-Infections in Disease-E
ndemic Areas

Room: São João de Rel

Speaker 3 of 5
Shona Wilson, University of Cambridge, UK
Impact of Co-Infection in Human Hepatic Diseases Caused by Parasites

Tuesday, March 17 | 5:00PM - 7:00PM
Immunological Effects of Parasite Co-Infections in Disease-E
ndemic Areas

Room: São João de Rel

Speaker 4 of 5
David Dunne, University of Cambridge, UK
Using Helminth Co-Infections to Study Modulation of Allergic Responses

Tuesday, March 17 | 5:00PM - 7:00PM
Immunological Effects of Parasite Co-Infections in Disease-E
ndemic Areas

Room: São João de Rel

Speaker 5 of 5
Daniel Hoces, ETH Zürich, Switzerland
Short Talk: Immunologic Hallmarks of Strongyloides stercoralis and HTLV-1 Co-Infection

Tuesday, March 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Tiradentes
No registration fees are used to fund alcohol served at this function.

Wednesday, March 18 | 7:30AM - 8:30AM
Breakfast
Room: Own Hotel


Wednesday, March 18 | 8:30AM - 11:45AM
Modeling Co-Infections to Improve Predictive and Interpretiv
e Capacity

Room: São João de Rel

Speaker 1 of 6
* Jacqueline Araújo Fiuza, René Rachou Center of Research, Brazil

Wednesday, March 18 | 8:30AM - 11:45AM
Modeling Co-Infections to Improve Predictive and Interpretiv
e Capacity

Room: São João de Rel

Speaker 2 of 6
Andy Fenton, University of Liverpool, UK
Modeling Population-Level Effects of Within-Host Interactions among Co-Infecting Parasites

Wednesday, March 18 | 8:30AM - 11:45AM
Modeling Co-Infections to Improve Predictive and Interpretiv
e Capacity

Room: São João de Rel

Speaker 3 of 6
Pedro Réu, Karolinska Institutet, Sweden
Inferring Pathogen Interactions from Epidemiological Data

Wednesday, March 18 | 8:30AM - 11:45AM
Modeling Co-Infections to Improve Predictive and Interpretiv
e Capacity

Room: São João de Rel

Speaker 4 of 6
Andrea L. Graham, Princeton University, USA
Predicting the Outcome of Microparasite-Helminth Co-Infection from First Principles, in Lab and Field

Wednesday, March 18 | 8:30AM - 11:45AM
Modeling Co-Infections to Improve Predictive and Interpretiv
e Capacity

Room: São João de Rel

Speaker 5 of 6
Lynn Meurs, Institute of Tropical Medicine, Belgium
Short Talk: Within-Host Interactions Drive Co-Occurrence of Schistosoma Mansoni and S. haematobium at the Local Level

Wednesday, March 18 | 8:30AM - 11:45AM
Modeling Co-Infections to Improve Predictive and Interpretiv
e Capacity

Room: São João de Rel

Speaker 6 of 6
Raquel Alves Pinna, Oswaldo Cruz Foundation, Brazil
Short Talk: Malaria-Cutaneous Leishmaniasis Co-Infection: Influence on Disease Outcomes

Wednesday, March 18 | 9:50AM - 10:10AM
Coffee Break
Room: Sabara


Wednesday, March 18 | 11:45AM - 1:00PM
Poster Setup
Room: Tiradentes


Wednesday, March 18 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, March 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Tiradentes


Wednesday, March 18 | 4:30PM - 5:00PM
Coffee Available
Room: Sabara


Wednesday, March 18 | 5:00PM - 7:00PM
Drug Treatment in Co-Infected Populations
Room: São João de Rel

Speaker 1 of 5
* Edgar M. Carvalho, Universidade Federal da Bahia, Brazil

Wednesday, March 18 | 5:00PM - 7:00PM
Drug Treatment in Co-Infected Populations
Room: São João de Rel

Speaker 2 of 5
Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
The Effect of Helminths on the Immune System and its Consequence for Malarial Parasitemia, Allergy and Homeostasis

Wednesday, March 18 | 5:00PM - 7:00PM
Drug Treatment in Co-Infected Populations
Room: São João de Rel

Speaker 3 of 5
Alison M. Elliott, MRC/UVRI & LSHTM Uganda Research Unit, Uganda
Co-Infection and the Hygiene Hypothesis: Insights from Africa

Wednesday, March 18 | 5:00PM - 7:00PM
Drug Treatment in Co-Infected Populations
Room: São João de Rel

Speaker 4 of 5
Jonathan A. McCullers, University of Tennessee Health Sciences Center, USA
Prevention and Treatment of the Consequences of Co-Infections

Wednesday, March 18 | 5:00PM - 7:00PM
Drug Treatment in Co-Infected Populations
Room: São João de Rel

Speaker 5 of 5
Pedro Gazzinelli-Guimaraes, NIAID, National Institutes of Health, USA
Short Talk: The Concomitant Larval Ascaris sp. Infection Downmodulates Vaccinia Virus-Specific Immune Response and Might Represent a Serious Risk for the Host

Wednesday, March 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Tiradentes
No registration fees are used to fund alcohol served at this function.

Wednesday, March 18 | 7:30PM - 10:00PM
Poster Session 2
Room: Tiradentes


Thursday, March 19 | 7:30AM - 8:30AM
Breakfast
Room: Own Hotel


Thursday, March 19 | 8:30AM - 5:00PM
Additional poster viewing of Poster Session 2
Room: Tiradentes


Thursday, March 19 | 8:30AM - 11:00AM
Co-Infections in the Context of Mucosal Microflora
Room: São João de Rel

Speaker 1 of 6
* Richard K. Grencis, University of Manchester, UK

Thursday, March 19 | 8:30AM - 11:00AM
Co-Infections in the Context of Mucosal Microflora
Room: São João de Rel

Speaker 2 of 6
W. Evan Secor, Centers for Disease Control and Prevention, USA
Parasitic Infections Affecting Genital Tract Mucosa Increase Risk of HIV Transmission

Thursday, March 19 | 8:30AM - 11:00AM
Co-Infections in the Context of Mucosal Microflora
Room: São João de Rel

Speaker 3 of 6
Jeffrey M. Bethony, George Washington University Medical Center, USA
Infection with the Carcinogenic Liver Fluke Opisthorchis viverrini Modifies Intestinal and Biliary Microbiome

Thursday, March 19 | 8:30AM - 11:00AM
Co-Infections in the Context of Mucosal Microflora
Room: São João de Rel

Speaker 4 of 6
Guido Silvestri, Emory University School of Medicine, USA
Microbial Translocation and Immunopathology in HIV Infection and AIDS

Thursday, March 19 | 8:30AM - 11:00AM
Co-Infections in the Context of Mucosal Microflora
Room: São João de Rel

Speaker 5 of 6
Taylor K. Oniskey, University of California, San Francisco, USA
Short Talk: Hookworm Pathogenesis Is Regulated by the Suppressive Role of Trefoil Factor Family Proteins

Thursday, March 19 | 8:30AM - 11:00AM
Co-Infections in the Context of Mucosal Microflora
Room: São João de Rel

Speaker 6 of 6
Renata Braga, Merck S.A., Brazil
Short Talk: Female Genital Schistosomiasis and its Impact on HIV/AIDS: Targeting to Address Impact of ‘Co-Infection’

Thursday, March 19 | 9:50AM - 10:10AM
Coffee Break
Room: Sabara


Thursday, March 19 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, March 19 | 4:30PM - 5:00PM
Coffee Available
Room: Sabara


Thursday, March 19 | 5:00PM - 6:45PM
Co-Infections and the Challenges for Vaccine Development
Room: São João de Rel

Speaker 1 of 5
* David Dunne, University of Cambridge, UK

Thursday, March 19 | 5:00PM - 6:45PM
Co-Infections and the Challenges for Vaccine Development
Room: São João de Rel

Speaker 2 of 5
Donald A. Harn, University of Georgia College of Veterinary Medicine, USA
New-Generation Vaccines against Helminths in Co-Infection Situations

Thursday, March 19 | 5:00PM - 6:45PM
Co-Infections and the Challenges for Vaccine Development
Room: São João de Rel

Speaker 3 of 5
Chiaka I. Anumudu, University of Ibadan, Nigeria
Short Talk: Co-Infections in Southwestern Nigeria: Puzzling through the Maze

Thursday, March 19 | 5:00PM - 6:45PM
Co-Infections and the Challenges for Vaccine Development
Room: São João de Rel

Speaker 4 of 5
Marguerite Massinga Loembe, Albert Schweitzer Hospital, Gabon
Short Talk

Thursday, March 19 | 5:00PM - 6:45PM
Co-Infections and the Challenges for Vaccine Development
Room: São João de Rel

Speaker 5 of 5
Ruthie Birger, Princeton University, USA
Short Talk: Modeling Impact of ART-MMT Scale-Up and HCV Therapy on HIV and HCV Burden among People Who Inject Drugs in Ho Chi Minh City, VN

Thursday, March 19 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: São João de Rel


Thursday, March 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Tiradentes
No registration fees are used to fund alcohol served at this function.

Thursday, March 19 | 8:00PM - 11:00PM
Entertainment
Room: Sabara
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 19 | 8:00PM - 11:00PM
Cash Bar
Room: Sabara


Friday, March 20 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.