Web Desc
Long Noncoding RNAs: From Evolution to Function
Organizer(s): Leonard Lipovich, Jeannie T. Lee, John L. Rinn and James (Ben) Brown
Date: March 15 - 20, 2015
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Cell Research, Isis Pharmaceuticals, Inc., Regeneron Pharmaceuticals, Inc. and Sarepta Therapeutics
Summary of Meeting:
It has become clear that metazoan genomes are replete with transcription from non-protein-coding regions, generating many long noncoding RNA (lncRNA) transcripts. Recent progress has enabled genome-wide mapping of lncRNAs and has unraveled unifying themes; lncRNAs function as epigenetic regulators, scaffolds, decoys, and enhancers. While these and other themes have been pursued in several meetings, the field has matured in numerous novel directions; the meeting leverages these to characterize lncRNAs comprehensively across metazoan genomes. The aim is to broaden our horizons with emerging data from humans and model systems, empowered by novel genomic technologies, including RNA-protein interaction mapping (CLIP- and RIP-seq), reverse genetics for lncRNAs not conserved in evolution (RNA sequencing in control and lncRNA-perturbed backgrounds), and proteogenomics to empirically bound the translational output of putative lncRNAomes. These topics have recently amassed diverse insights into RNA biology. The meeting should integrate novel findings, enhance previously proposed models of lncRNA function and generate new testable hypotheses. Synthesis of RNA structure, function, evolution and informatics will foster progress in this rapidly growing field.
Scholarship Deadline: November 18 2014
Discounted Abstract Deadline: November 18 2014
Abstract Deadline: December 16 2014
Discounted Registration Deadline: January 15 2015
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Cell ResearchIsis Pharmaceuticals, Inc.Regeneron Pharmaceuticals, Inc.Sarepta Therapeutics
We gratefully acknowledge additional support for this conference from:
Biosearch TechnologiesDharmacon, part of GE HealthcareExiqon A/SRaNA Therapeutics Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Isis Pharmaceuticals, Inc.

RaNA Therapeutics Inc.


Biosearch Technologies
We gratefully acknowledge the generous grant for this conference provided by:

National Human Genome Research Institute (NHGRI)
Grant No. 1R13HG008329-01
Funding for this conference was made possible (in part) by 1 R13 HG 008329 - 01 from the National Human Genome Research Institute (NHGRI) and the National Institute for Environmental Health Sciences (NIEHS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 15 | 4:00PM - 8:00PM
Arrival and Registration
Room: Keystone Lodge Lobby


Sunday, March 15 | 6:00PM - 8:00PM
Welcome Mixer
Room: Keystone Lodge-Bighorn Bar
No registration fees are used to fund alcohol served at this function.

Monday, March 16 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Monday, March 16 | 8:00AM - 8:15AM
Welcome Remarks
Room: Grays Peak

Speaker 1 of 4
Leonard Lipovich, Wayne State University, USA

Monday, March 16 | 8:00AM - 8:15AM
Welcome Remarks
Room: Grays Peak

Speaker 2 of 4
Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA

Monday, March 16 | 8:00AM - 8:15AM
Welcome Remarks
Room: Grays Peak

Speaker 3 of 4
James (Ben) Brown, Lawrence Berkeley National Laboratory, USA

Monday, March 16 | 8:00AM - 8:15AM
Welcome Remarks
Room: Grays Peak

Speaker 4 of 4
John L. Rinn, University of Colorado Boulder, USA

Monday, March 16 | 8:15AM - 9:45AM
Keynote Session
Room: Grays Peak

Speaker 1 of 3
* James (Ben) Brown, Lawrence Berkeley National Laboratory, USA

Monday, March 16 | 8:15AM - 9:45AM
Keynote Session
Room: Grays Peak

Speaker 2 of 3
Thomas R. Cech, HHMI/University of Colorado, USA
A Short History of Noncoding RNA Research

Monday, March 16 | 8:15AM - 9:45AM
Keynote Session
Room: Grays Peak

Speaker 3 of 3
Lynne E. Maquat, University of Rochester Medical Center, USA
Control of Gene Expression via lncRNAs and mRNAs that Contain SINEs

Monday, March 16 | 9:45AM - 10:05AM
Coffee Break
Room: Longs Peak Foyer


Monday, March 16 | 10:05AM - 11:45AM
The Multidimensional lncRNA Landscape
Room: Grays Peak
This session interrogates the genomic and subcellular cartography of long noncoding transcripts in metazoans. The speakers will leverage ENCODE and other community results and next-generation sequencing to emerge with a functional catalog of mammalian lncRNA genes and transcripts, as well as a unifying nomenclature for the lncRNA community.
Speaker 1 of 4
* John L. Rinn, University of Colorado Boulder, USA

Monday, March 16 | 10:05AM - 11:45AM
The Multidimensional lncRNA Landscape
Room: Grays Peak
This session interrogates the genomic and subcellular cartography of long noncoding transcripts in metazoans. The speakers will leverage ENCODE and other community results and next-generation sequencing to emerge with a functional catalog of mammalian lncRNA genes and transcripts, as well as a unifying nomenclature for the lncRNA community.
Speaker 2 of 4
John S. Mattick, University of Oxford, UK
The Human Genome as the Zip File Extraordinaire

Monday, March 16 | 10:05AM - 11:45AM
The Multidimensional lncRNA Landscape
Room: Grays Peak
This session interrogates the genomic and subcellular cartography of long noncoding transcripts in metazoans. The speakers will leverage ENCODE and other community results and next-generation sequencing to emerge with a functional catalog of mammalian lncRNA genes and transcripts, as well as a unifying nomenclature for the lncRNA community.
Speaker 3 of 4
Nenad Bartonicek, Garvan Institute of Medical Research, Australia
Short Talk: Uncovering Hidden Genes in Intergenic GWAS Regions

Monday, March 16 | 10:05AM - 11:45AM
The Multidimensional lncRNA Landscape
Room: Grays Peak
This session interrogates the genomic and subcellular cartography of long noncoding transcripts in metazoans. The speakers will leverage ENCODE and other community results and next-generation sequencing to emerge with a functional catalog of mammalian lncRNA genes and transcripts, as well as a unifying nomenclature for the lncRNA community.
Speaker 4 of 4
Sanjida H. Rangwala, National Institutes of Health, USA
Short Talk: Curation and Evidence Reporting of Eukaryotic RefSeq Long Noncoding RNA Genes and Transcripts

Monday, March 16 | 11:45AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Monday, March 16 | 11:45AM - 2:30PM
On Own for Lunch


Monday, March 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Monday, March 16 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 1 of 8
* Anna Roth, German Cancer Research Center, DKFZ, Germany

Monday, March 16 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 2 of 8
Mitchell R. O'Connell, University of Rochester Medical Center, USA
Programmable RNA Targeting and Cleavage by CRISPR/Cas9

Monday, March 16 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 3 of 8
Guruharsha Kuthethur Gururaj, Biogen Inc., USA
Mapping RNA-Protein Interaction Modules Important in Neurodegeneration

Monday, March 16 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 4 of 8
Hans E. Johansson, LGC Biosearch Technologies, USA
Duplex Imaging of Pre-lncRNAs and Mature lncRNAs by Stellaris® RNA Fluorescence in situ Hybridization (RNA FISH)

Monday, March 16 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 5 of 8
* Mathew Thayer, Oregon Health & Science University, USA
Large Noncoding RNA Genes Control Chromosome-Wide Replication Timing and Stability

Monday, March 16 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 6 of 8
Karyn Schmidt, Alnylam Pharmaceuticals, USA
Characterization of a lncRNA Contributing to Melanoma Invasion

Monday, March 16 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 7 of 8
Martin A. Smith, Garvan Institute of Medical Research, Australia
The Modular Transcriptome: Unraveling a Network of Functional, Structured Noncoding RNA Domains

Monday, March 16 | 2:30PM - 4:30PM
Workshop 1
Room: Grays Peak

Speaker 8 of 8
Per Johnsson, Karolinska Institutet, Sweden
A Novel Role of PTENpg1 as RNA in Drug Response and Outcome in Melanoma

Monday, March 16 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 16 | 5:00PM - 7:15PM
LncRNA Form and Function
Room: Grays Peak
This session introduces current challenges in, and methods for studying, lncRNA secondary structure and lncRNA-containing ribonucleoprotein complexes. Presentations will inspire and motivate whole-genome approaches to lncRNA structure, lncRNPs and lncRNA post-transcriptional modifications.
Speaker 1 of 6
* Karissa Y. Sanbonmatsu, Los Alamos National Laboratory, USA

Monday, March 16 | 5:00PM - 7:15PM
LncRNA Form and Function
Room: Grays Peak
This session introduces current challenges in, and methods for studying, lncRNA secondary structure and lncRNA-containing ribonucleoprotein complexes. Presentations will inspire and motivate whole-genome approaches to lncRNA structure, lncRNPs and lncRNA post-transcriptional modifications.
Speaker 2 of 6
Phillip A. Sharp, Massachusetts Institute of Technology, USA
Origins of Long Noncoding RNAs and New Families of Argonaute-Associated Nuclear RNAs

Monday, March 16 | 5:00PM - 7:15PM
LncRNA Form and Function
Room: Grays Peak
This session introduces current challenges in, and methods for studying, lncRNA secondary structure and lncRNA-containing ribonucleoprotein complexes. Presentations will inspire and motivate whole-genome approaches to lncRNA structure, lncRNPs and lncRNA post-transcriptional modifications.
Speaker 3 of 6
Ingrid Grummt, German Cancer Research Center, Germany
DNA:RNA Triplexes Guide Chromatin Modifiers to Regulatory Gene Sequences

Monday, March 16 | 5:00PM - 7:15PM
LncRNA Form and Function
Room: Grays Peak
This session introduces current challenges in, and methods for studying, lncRNA secondary structure and lncRNA-containing ribonucleoprotein complexes. Presentations will inspire and motivate whole-genome approaches to lncRNA structure, lncRNPs and lncRNA post-transcriptional modifications.
Speaker 4 of 6
Boris Guennewig, Garvan Institute of Medical Research, Australia
Short Talk: Functional Characterization of the Human Brain Transcriptome in Parkinson’s Disease

Monday, March 16 | 5:00PM - 7:15PM
LncRNA Form and Function
Room: Grays Peak
This session introduces current challenges in, and methods for studying, lncRNA secondary structure and lncRNA-containing ribonucleoprotein complexes. Presentations will inspire and motivate whole-genome approaches to lncRNA structure, lncRNPs and lncRNA post-transcriptional modifications.
Speaker 5 of 6
Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs

Monday, March 16 | 5:00PM - 7:15PM
LncRNA Form and Function
Room: Grays Peak
This session introduces current challenges in, and methods for studying, lncRNA secondary structure and lncRNA-containing ribonucleoprotein complexes. Presentations will inspire and motivate whole-genome approaches to lncRNA structure, lncRNPs and lncRNA post-transcriptional modifications.
Speaker 6 of 6
Anindya Dutta, University of Virginia, USA
Short Talk: Long Noncoding RNAs, H19 and MUNC, Promote Skeletal Muscle Differentiation by Two Different Mechanisms

Monday, March 16 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Monday, March 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Tuesday, March 17 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Tuesday, March 17 | 8:00AM - 11:15AM
LncRNA Evolution: Non-Conserved Functions and Species Unique
ness

Room: Grays Peak
Here, we will focus on one of the grandest challenges in contemporary biology: Why are the sequences of biologically essential lncRNAs - in contrast to protein-coding genes - often not conserved, even between closely related species? The speakers will discuss functions of non-conserved lncRNAs, focusing on lncRNA roles in species phenotypic uniqueness, species-specific disease, and networks that highlight the need to leverage clinical studies and samples in the pursuit of basic science.
Speaker 1 of 6
* Kevin V. Morris, Center for Gene Therapy, City of Hope, USA

Tuesday, March 17 | 8:00AM - 11:15AM
LncRNA Evolution: Non-Conserved Functions and Species Unique
ness

Room: Grays Peak
Here, we will focus on one of the grandest challenges in contemporary biology: Why are the sequences of biologically essential lncRNAs - in contrast to protein-coding genes - often not conserved, even between closely related species? The speakers will discuss functions of non-conserved lncRNAs, focusing on lncRNA roles in species phenotypic uniqueness, species-specific disease, and networks that highlight the need to leverage clinical studies and samples in the pursuit of basic science.
Speaker 2 of 6
Leonard Lipovich, Wayne State University, USA
The Primate-Specific LncRNAome: Roles in Species Uniqueness, Human Brain and Cancer

Tuesday, March 17 | 8:00AM - 11:15AM
LncRNA Evolution: Non-Conserved Functions and Species Unique
ness

Room: Grays Peak
Here, we will focus on one of the grandest challenges in contemporary biology: Why are the sequences of biologically essential lncRNAs - in contrast to protein-coding genes - often not conserved, even between closely related species? The speakers will discuss functions of non-conserved lncRNAs, focusing on lncRNA roles in species phenotypic uniqueness, species-specific disease, and networks that highlight the need to leverage clinical studies and samples in the pursuit of basic science.
Speaker 3 of 6
Jennifer Harrow, Wellcome Trust Sanger Institute, UK
Identifying and Cataloguing Functional LncRNAs in Reference Genomes

Tuesday, March 17 | 8:00AM - 11:15AM
LncRNA Evolution: Non-Conserved Functions and Species Unique
ness

Room: Grays Peak
Here, we will focus on one of the grandest challenges in contemporary biology: Why are the sequences of biologically essential lncRNAs - in contrast to protein-coding genes - often not conserved, even between closely related species? The speakers will discuss functions of non-conserved lncRNAs, focusing on lncRNA roles in species phenotypic uniqueness, species-specific disease, and networks that highlight the need to leverage clinical studies and samples in the pursuit of basic science.
Speaker 4 of 6
Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany
Circular RNAs in the Mammalian Brain

Tuesday, March 17 | 8:00AM - 11:15AM
LncRNA Evolution: Non-Conserved Functions and Species Unique
ness

Room: Grays Peak
Here, we will focus on one of the grandest challenges in contemporary biology: Why are the sequences of biologically essential lncRNAs - in contrast to protein-coding genes - often not conserved, even between closely related species? The speakers will discuss functions of non-conserved lncRNAs, focusing on lncRNA roles in species phenotypic uniqueness, species-specific disease, and networks that highlight the need to leverage clinical studies and samples in the pursuit of basic science.
Speaker 5 of 6
Piero Carninci, RIKEN Center for Life Science Technologies/TransSINE Technologies Inc., Japan
Discovery and Potential Therapeutic Applications of SINEUPs, lncRNA that Stimulate Protein Translation

Tuesday, March 17 | 8:00AM - 11:15AM
LncRNA Evolution: Non-Conserved Functions and Species Unique
ness

Room: Grays Peak
Here, we will focus on one of the grandest challenges in contemporary biology: Why are the sequences of biologically essential lncRNAs - in contrast to protein-coding genes - often not conserved, even between closely related species? The speakers will discuss functions of non-conserved lncRNAs, focusing on lncRNA roles in species phenotypic uniqueness, species-specific disease, and networks that highlight the need to leverage clinical studies and samples in the pursuit of basic science.
Speaker 6 of 6
Jonathan S. Weissman, Whitehead Institute and MIT, USA
Exploring Translation Outside of Canonical Protein Coding Region with Ribosome Profiling

Tuesday, March 17 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, March 17 | 11:15AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Tuesday, March 17 | 11:15AM - 2:30PM
On Own for Lunch


Tuesday, March 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Tuesday, March 17 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 1 of 9
* Howard Y. Chang, Stanford University, USA

Tuesday, March 17 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 2 of 9
* Marina Barriocanal, University of Navarra - FIMA, Spain

Tuesday, March 17 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 3 of 9
Brian S. Clark, Johns Hopkins University, USA
Dynamic Expression of lncRNAs and Examination of their Role in Retinal Progenitor Competence

Tuesday, March 17 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 4 of 9
Rohit Malik, University of Michigan, USA
Integrative Analysis of Androgen Receptor Regulated Long Noncoding RNA in Prostate Cancer

Tuesday, March 17 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 5 of 9
Maninjay K. Atianand, University of Massachusetts Medical School, USA
LincRNA-Eps Controls Immune Responses in Macrophage and Mice

Tuesday, March 17 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 6 of 9
Evan S. Forsythe, University of Arizona, USA
Phylogenetic Analysis of lincRNA Origins and Evolution in the Plant Family Brassicaceae

Tuesday, March 17 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 7 of 9
Jhumku D. Kohtz, Feinberg School of Medicine, Northwestern University, USA
The Ultraconserved Evf2 lncRNA Reduces Seizure Susceptibility in Mice

Tuesday, March 17 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 8 of 9
Hazuki Takahashi, RIKEN, Japan
Mapping of Functional Domains of SINEUPs, Antisense lncRNAs that Enhance Protein Translation

Tuesday, March 17 | 2:30PM - 4:30PM
Workshop 2
Room: Grays Peak

Speaker 9 of 9
Susan A. Boackle, University of Colorado School of Medicine, USA
Altered Expression of Long Noncoding RNA Is Associated with a Lupus-Associated Variant in Complement Receptor 2

Tuesday, March 17 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, March 17 | 5:00PM - 7:15PM
In vivo Roles of lncRNAs: The Promises and Limitations of An
imal Models

Room: Grays Peak
Animal models for conserved lncRNAs with crucial human disease functions, such as MALAT-1, have surprisingly failed to recapitulate the human phenotypes. The goal of this session is to develop a mechanistic understanding of these limitations - and to highlight other animal models in which human lncRNAs, including non-conserved ones, can be more tractable.
Speaker 1 of 7
* Leonard Lipovich, Wayne State University, USA

Tuesday, March 17 | 5:00PM - 7:15PM
In vivo Roles of lncRNAs: The Promises and Limitations of An
imal Models

Room: Grays Peak
Animal models for conserved lncRNAs with crucial human disease functions, such as MALAT-1, have surprisingly failed to recapitulate the human phenotypes. The goal of this session is to develop a mechanistic understanding of these limitations - and to highlight other animal models in which human lncRNAs, including non-conserved ones, can be more tractable.
Speaker 2 of 7
Alexandra Henrion-Caude, Necker Hospital – Imagine Foundation, France
Learning about Human lncRNA by Repetition and Reduction

Tuesday, March 17 | 5:00PM - 7:15PM
In vivo Roles of lncRNAs: The Promises and Limitations of An
imal Models

Room: Grays Peak
Animal models for conserved lncRNAs with crucial human disease functions, such as MALAT-1, have surprisingly failed to recapitulate the human phenotypes. The goal of this session is to develop a mechanistic understanding of these limitations - and to highlight other animal models in which human lncRNAs, including non-conserved ones, can be more tractable.
Speaker 3 of 7
Kevin G. Nyberg, Northwestern University, USA
Short Talk: Comparative Transcriptomics of Long Intergenic Noncoding RNAs in Drosophila

Tuesday, March 17 | 5:00PM - 7:15PM
In vivo Roles of lncRNAs: The Promises and Limitations of An
imal Models

Room: Grays Peak
Animal models for conserved lncRNAs with crucial human disease functions, such as MALAT-1, have surprisingly failed to recapitulate the human phenotypes. The goal of this session is to develop a mechanistic understanding of these limitations - and to highlight other animal models in which human lncRNAs, including non-conserved ones, can be more tractable.
Speaker 4 of 7
Ciro Bonetti, Regeneron Pharmaceuticals, USA
Short Talk: Mouse Models to Dissect Oncogenic and Tumor-Suppressive Functions of lincRNAs

Tuesday, March 17 | 5:00PM - 7:15PM
In vivo Roles of lncRNAs: The Promises and Limitations of An
imal Models

Room: Grays Peak
Animal models for conserved lncRNAs with crucial human disease functions, such as MALAT-1, have surprisingly failed to recapitulate the human phenotypes. The goal of this session is to develop a mechanistic understanding of these limitations - and to highlight other animal models in which human lncRNAs, including non-conserved ones, can be more tractable.
Speaker 5 of 7
Sven Diederichs, University of Freiburg, Germany
Long Noncoding RNA Function in Cancer

Tuesday, March 17 | 5:00PM - 7:15PM
In vivo Roles of lncRNAs: The Promises and Limitations of An
imal Models

Room: Grays Peak
Animal models for conserved lncRNAs with crucial human disease functions, such as MALAT-1, have surprisingly failed to recapitulate the human phenotypes. The goal of this session is to develop a mechanistic understanding of these limitations - and to highlight other animal models in which human lncRNAs, including non-conserved ones, can be more tractable.
Speaker 6 of 7
Caio F. Damski, University of New South Wales, Australia
Short Talk: Saving the Devil; lncRNA Directed Epigenetic Changes in a Contagious Cancer

Tuesday, March 17 | 5:00PM - 7:15PM
In vivo Roles of lncRNAs: The Promises and Limitations of An
imal Models

Room: Grays Peak
Animal models for conserved lncRNAs with crucial human disease functions, such as MALAT-1, have surprisingly failed to recapitulate the human phenotypes. The goal of this session is to develop a mechanistic understanding of these limitations - and to highlight other animal models in which human lncRNAs, including non-conserved ones, can be more tractable.
Speaker 7 of 7
Matthew G. Schwartz, Harvard Medical School, USA
Short Talk: The Role of Long Noncoding RNAs in Regulating Chicken Limb Development

Tuesday, March 17 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Tuesday, March 17 | 7:30PM - 10:00PM
Poster Session 2
Room: Shavano/Torreys


Wednesday, March 18 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Wednesday, March 18 | 8:00AM - 11:00AM
LncRNA Mechanisms: Diversity and Heterogeneity
Room: Grays Peak
Epigenetic or post-transcriptional? Nuclear or cytoplasmic? Single-gene antisense regulators or network cascade amplifiers? This session will present the frontiers of current knowledge about metazoan lncRNA functional mechanisms, and motivate the development of specific approaches to survey and target these mechanisms on a whole-transcriptome scale.
Speaker 1 of 7
* Jhumku D. Kohtz, Feinberg School of Medicine, Northwestern University, USA

Wednesday, March 18 | 8:00AM - 11:00AM
LncRNA Mechanisms: Diversity and Heterogeneity
Room: Grays Peak
Epigenetic or post-transcriptional? Nuclear or cytoplasmic? Single-gene antisense regulators or network cascade amplifiers? This session will present the frontiers of current knowledge about metazoan lncRNA functional mechanisms, and motivate the development of specific approaches to survey and target these mechanisms on a whole-transcriptome scale.
Speaker 2 of 7
Ramin Shiekhattar, University of Miami, USA
Biogenesis and Mechanism of Action of Enhancer RNA

Wednesday, March 18 | 8:00AM - 11:00AM
LncRNA Mechanisms: Diversity and Heterogeneity
Room: Grays Peak
Epigenetic or post-transcriptional? Nuclear or cytoplasmic? Single-gene antisense regulators or network cascade amplifiers? This session will present the frontiers of current knowledge about metazoan lncRNA functional mechanisms, and motivate the development of specific approaches to survey and target these mechanisms on a whole-transcriptome scale.
Speaker 3 of 7
Kevin V. Morris, Center for Gene Therapy, City of Hope, USA
RNA-Directed Modulation of Phenotypic Plasticity in Human Cells

Wednesday, March 18 | 8:00AM - 11:00AM
LncRNA Mechanisms: Diversity and Heterogeneity
Room: Grays Peak
Epigenetic or post-transcriptional? Nuclear or cytoplasmic? Single-gene antisense regulators or network cascade amplifiers? This session will present the frontiers of current knowledge about metazoan lncRNA functional mechanisms, and motivate the development of specific approaches to survey and target these mechanisms on a whole-transcriptome scale.
Speaker 4 of 7
Nicholas Lister, University of New South Wales, Australia
Short Talk: Promoter-Associated Transcripts Are Required for PTENpg1 Antisense RNA-Directed Epigenetic Regulation of PTEN

Wednesday, March 18 | 8:00AM - 11:00AM
LncRNA Mechanisms: Diversity and Heterogeneity
Room: Grays Peak
Epigenetic or post-transcriptional? Nuclear or cytoplasmic? Single-gene antisense regulators or network cascade amplifiers? This session will present the frontiers of current knowledge about metazoan lncRNA functional mechanisms, and motivate the development of specific approaches to survey and target these mechanisms on a whole-transcriptome scale.
Speaker 5 of 7
Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA
RNA-Protein Interactions in Epigenetic Regulation

Wednesday, March 18 | 8:00AM - 11:00AM
LncRNA Mechanisms: Diversity and Heterogeneity
Room: Grays Peak
Epigenetic or post-transcriptional? Nuclear or cytoplasmic? Single-gene antisense regulators or network cascade amplifiers? This session will present the frontiers of current knowledge about metazoan lncRNA functional mechanisms, and motivate the development of specific approaches to survey and target these mechanisms on a whole-transcriptome scale.
Speaker 6 of 7
Richard G. Jenner, University College London, UK
Short Talk: Polycomb Repressive Complex 2 Directly Interacts with RNA through Suz12 and Is Independent of Chromatin Association

Wednesday, March 18 | 8:00AM - 11:00AM
LncRNA Mechanisms: Diversity and Heterogeneity
Room: Grays Peak
Epigenetic or post-transcriptional? Nuclear or cytoplasmic? Single-gene antisense regulators or network cascade amplifiers? This session will present the frontiers of current knowledge about metazoan lncRNA functional mechanisms, and motivate the development of specific approaches to survey and target these mechanisms on a whole-transcriptome scale.
Speaker 7 of 7
Reini F. Luco, Centre National de la Recherche Scientifique, France
Short Talk: A Long Noncoding RNA Regulates Chromatin-Mediated Modulation of Alternative Splicing

Wednesday, March 18 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, March 18 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Wednesday, March 18 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, March 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Wednesday, March 18 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 1 of 8
* Ranjan J. Perera, Sanford Burnham Prebys Medical Discovery Institute, USA

Wednesday, March 18 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 2 of 8
* Emily R. Feldman, University of Florida, USA

Wednesday, March 18 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 3 of 8
Zhuo Zhou, NIDDK, National Institutes of Health, USA
RNA-Dependent Triplex Formation Regulates Expression of Erythroid Genes

Wednesday, March 18 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 4 of 8
Valerie Brid O'Leary, Helmholtz Zentrum Muenchen, Germany
PARTICLE – A Long Noncoding RNA Modulator of Cellular Methylation in Response to Low Dose Irradiation

Wednesday, March 18 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 5 of 8
Fabien Dachet, University of Illinois at Chicago School of Medicine, USA
Epigenetic Organization of Protein Coding and Large Noncoding Transcripts in Electrically Active Human Brain

Wednesday, March 18 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 6 of 8
Yuya Ogawa, Cincinnati Children's Hospital Medical Center, USA
Xist Exon 7 Contributes to the Stable Localization of Xist RNA on the Inactive X-Chromosome

Wednesday, March 18 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 7 of 8
Karissa Y. Sanbonmatsu, Los Alamos National Laboratory, USA
Structural Studies of Long Noncoding RNAs

Wednesday, March 18 | 2:30PM - 4:30PM
Workshop 3
Room: Grays Peak

Speaker 8 of 8
Luis Arnes, Columbia University, USA
Examining the Role of Novel Long Noncoding RNAs in beta Cell Biology

Wednesday, March 18 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, March 18 | 5:00PM - 7:00PM
Conserved lncRNA Functions
Room: Grays Peak
This session serves as a forum for whole-transcriptome lncRNA functional studies in model organisms, with an emphasis on observations that point to transgenerational transmission. This emerging frontier of lncRNA research holds intriguing implications for development and behavior.
Speaker 1 of 6
* Alexandra Henrion-Caude, Necker Hospital – Imagine Foundation, France

Wednesday, March 18 | 5:00PM - 7:00PM
Conserved lncRNA Functions
Room: Grays Peak
This session serves as a forum for whole-transcriptome lncRNA functional studies in model organisms, with an emphasis on observations that point to transgenerational transmission. This emerging frontier of lncRNA research holds intriguing implications for development and behavior.
Speaker 2 of 6
James (Ben) Brown, Lawrence Berkeley National Laboratory, USA
Long Noncoding RNAs and Adaptive Responses to Environmental Stressors

Wednesday, March 18 | 5:00PM - 7:00PM
Conserved lncRNA Functions
Room: Grays Peak
This session serves as a forum for whole-transcriptome lncRNA functional studies in model organisms, with an emphasis on observations that point to transgenerational transmission. This emerging frontier of lncRNA research holds intriguing implications for development and behavior.
Speaker 3 of 6
Mridula (Millie) K. Ray, Harvard University, Massachusetts General Hospital, USA
Short Talk: lncRNAs Interact with PRC1 to Impact Development in Human and Zebrafish

Wednesday, March 18 | 5:00PM - 7:00PM
Conserved lncRNA Functions
Room: Grays Peak
This session serves as a forum for whole-transcriptome lncRNA functional studies in model organisms, with an emphasis on observations that point to transgenerational transmission. This emerging frontier of lncRNA research holds intriguing implications for development and behavior.
Speaker 4 of 6
John L. Rinn, University of Colorado Boulder, USA
Linking RNA from Mouse to Mechanism

Wednesday, March 18 | 5:00PM - 7:00PM
Conserved lncRNA Functions
Room: Grays Peak
This session serves as a forum for whole-transcriptome lncRNA functional studies in model organisms, with an emphasis on observations that point to transgenerational transmission. This emerging frontier of lncRNA research holds intriguing implications for development and behavior.
Speaker 5 of 6
David J. Waxman, Boston University, USA
Short Talk: Mouse Liver lincRNAs: Gene Structures, Chromatin States, Conservation and Regulation of Sex-Specific Transcription by Pituitary Growth Hormone (GH)

Wednesday, March 18 | 5:00PM - 7:00PM
Conserved lncRNA Functions
Room: Grays Peak
This session serves as a forum for whole-transcriptome lncRNA functional studies in model organisms, with an emphasis on observations that point to transgenerational transmission. This emerging frontier of lncRNA research holds intriguing implications for development and behavior.
Speaker 6 of 6
Colleen A. McHugh, California Institute of Technology, USA
Short Talk: Uncovering Mechanisms of lncRNA Function through Comprehensive Identification of Direct lncRNA-Interacting Proteins in vivo

Wednesday, March 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Wednesday, March 18 | 7:30PM - 10:00PM
Poster Session 3
Room: Shavano/Torreys


Thursday, March 19 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Thursday, March 19 | 8:00AM - 11:30AM
Transcription Factors and lncRNAs: Direct Endogenous Riboreg
ulation

Room: Grays Peak
A highlight of 21st-century lncRNAomics has been the discovery that transcription factors including homeobox proteins and multiple nuclear hormone receptors, as well as epigenetic modifiers, directly interact with lncRNAs. This session discusses the impact of these interactions on gene regulation.
Speaker 1 of 8
* Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA

Thursday, March 19 | 8:00AM - 11:30AM
Transcription Factors and lncRNAs: Direct Endogenous Riboreg
ulation

Room: Grays Peak
A highlight of 21st-century lncRNAomics has been the discovery that transcription factors including homeobox proteins and multiple nuclear hormone receptors, as well as epigenetic modifiers, directly interact with lncRNAs. This session discusses the impact of these interactions on gene regulation.
Speaker 2 of 8
David R. Corey, University of Texas Southwestern Medical Center, USA
Nuclear RNAi: Connecting lncRNAs with Sequence-Specific Regulation of Transcription and Splicing

Thursday, March 19 | 8:00AM - 11:30AM
Transcription Factors and lncRNAs: Direct Endogenous Riboreg
ulation

Room: Grays Peak
A highlight of 21st-century lncRNAomics has been the discovery that transcription factors including homeobox proteins and multiple nuclear hormone receptors, as well as epigenetic modifiers, directly interact with lncRNAs. This session discusses the impact of these interactions on gene regulation.
Speaker 3 of 8
Vladimir Bajic, King Abdullah University of Science and Technology, Saudi Arabia
Protein-Coding and lncRNA Genes Are Regulated Differently: Feedback Loops with lncRNA-Interacting Transcription Factors

Thursday, March 19 | 8:00AM - 11:30AM
Transcription Factors and lncRNAs: Direct Endogenous Riboreg
ulation

Room: Grays Peak
A highlight of 21st-century lncRNAomics has been the discovery that transcription factors including homeobox proteins and multiple nuclear hormone receptors, as well as epigenetic modifiers, directly interact with lncRNAs. This session discusses the impact of these interactions on gene regulation.
Speaker 4 of 8
Michael G. Rosenfeld, University of California, San Diego, USA
Enhancer Signatures eRNAs and Nuclear Architecture in Regulated Gene Transcription

Thursday, March 19 | 8:00AM - 11:30AM
Transcription Factors and lncRNAs: Direct Endogenous Riboreg
ulation

Room: Grays Peak
A highlight of 21st-century lncRNAomics has been the discovery that transcription factors including homeobox proteins and multiple nuclear hormone receptors, as well as epigenetic modifiers, directly interact with lncRNAs. This session discusses the impact of these interactions on gene regulation.
Speaker 5 of 8
Veronica Peschansky, University of Miami, USA
Short Talk: Fragile X-Associated lncRNA FMR4 Is Trans-Active, Involved in Neural Development and Localized to Chromatin

Thursday, March 19 | 8:00AM - 11:30AM
Transcription Factors and lncRNAs: Direct Endogenous Riboreg
ulation

Room: Grays Peak
A highlight of 21st-century lncRNAomics has been the discovery that transcription factors including homeobox proteins and multiple nuclear hormone receptors, as well as epigenetic modifiers, directly interact with lncRNAs. This session discusses the impact of these interactions on gene regulation.
Speaker 6 of 8
Katelin R. Haynes, University of Queensland Diamantina Institute, Australia
Short Talk: Identification of Monocyte-Specific eRNAs at an Intergenic GWAS Locus Associated with Ankylosing Spondylitis Reveals Potential Mechanism in Disease

Thursday, March 19 | 8:00AM - 11:30AM
Transcription Factors and lncRNAs: Direct Endogenous Riboreg
ulation

Room: Grays Peak
A highlight of 21st-century lncRNAomics has been the discovery that transcription factors including homeobox proteins and multiple nuclear hormone receptors, as well as epigenetic modifiers, directly interact with lncRNAs. This session discusses the impact of these interactions on gene regulation.
Speaker 7 of 8
Jennifer F. Kugel, University of Colorado Boulder, USA
Regulation of RNA Polymerase II by SINE-Encoded ncRNAs

Thursday, March 19 | 8:00AM - 11:30AM
Transcription Factors and lncRNAs: Direct Endogenous Riboreg
ulation

Room: Grays Peak
A highlight of 21st-century lncRNAomics has been the discovery that transcription factors including homeobox proteins and multiple nuclear hormone receptors, as well as epigenetic modifiers, directly interact with lncRNAs. This session discusses the impact of these interactions on gene regulation.
Speaker 8 of 8
Jesse M. Engreitz, Harvard University and Broad Institute, USA
Short Talk: Many Nuclear-Localized lincRNAs Regulate Gene Expression in cis

Thursday, March 19 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, March 19 | 11:30AM - 2:30PM
On Own for Lunch


Thursday, March 19 | 2:30PM - 4:30PM
Workshop 4
Room: Grays Peak

Speaker 1 of 9
* Saba Valadkhan, Case Western Reserve University, USA

Thursday, March 19 | 2:30PM - 4:30PM
Workshop 4
Room: Grays Peak

Speaker 2 of 9
* Ashley R. Hoover, University of Texas Southwestern Medical Center, USA

Thursday, March 19 | 2:30PM - 4:30PM
Workshop 4
Room: Grays Peak

Speaker 3 of 9
Fan Lai, University of Miami, USA
Integrator Mediates the Biogenesis of Enhancer RNAs

Thursday, March 19 | 2:30PM - 4:30PM
Workshop 4
Room: Grays Peak

Speaker 4 of 9
Shrikanth S. Gadad, Texas Tech University Health Sciences Center, USA
Functional Characterization of an Estrogen-Regulated Long Noncoding RNA that Controls the Growth of Breast Cancer Cells

Thursday, March 19 | 2:30PM - 4:30PM
Workshop 4
Room: Grays Peak

Speaker 5 of 9
Maren M. Gross, Dharmacon, a Horizon Discovery Group Company, USA
Knockdown of Long Noncoding RNAs in Breast Cancer

Thursday, March 19 | 2:30PM - 4:30PM
Workshop 4
Room: Grays Peak

Speaker 6 of 9
Musa M. Mhlanga, Radboud Institute for Molecular Life Sciences, Netherlands
HIV-1 Targets MAP2K1/ERK2 to Evade lincRNA-p21-Mediated Apoptosis

Thursday, March 19 | 2:30PM - 4:30PM
Workshop 4
Room: Grays Peak

Speaker 7 of 9
Margaret D. Ballantyne, University of Glasgow, UK
Cytokine and Growth Factor Induction of lncRNA in Vascular Smooth Muscle Cells

Thursday, March 19 | 2:30PM - 4:30PM
Workshop 4
Room: Grays Peak

Speaker 8 of 9
Damien Hermand, University of Namur, Belgium
Timely Entry into Gametogenesis Regulated by a Modified cis-Acting LINC-RNA in Fission Yeast

Thursday, March 19 | 2:30PM - 4:30PM
Workshop 4
Room: Grays Peak

Speaker 9 of 9
Felipe Beckedorff, Universidade de São Paulo, Brazil
LincRNAs Enriched for Enhancer Histone Signatures Are Involved in the Activation of Genes Regulated by Androgen

Thursday, March 19 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, March 19 | 5:00PM - 7:30PM
LncRNAs in Human Disease: Toward Rational Ribo-Therapeutics
Room: Grays Peak
This session will survey direct functional evidence implicating lncRNAs as causes of human disease, and also identify settings where lncRNAs without obvious endogenous function may serve as therapeutic targets. Harnessing the power of lncRNAomics to impute and perturb lncRNA-dependent regulatory networks, the session will canvass cutting-edge developments in industry, where rational therapeutics targeting lncRNA disease mechanisms are being developed.
Speaker 1 of 6
* Luis Arnes, Columbia University, USA

Thursday, March 19 | 5:00PM - 7:30PM
LncRNAs in Human Disease: Toward Rational Ribo-Therapeutics
Room: Grays Peak
This session will survey direct functional evidence implicating lncRNAs as causes of human disease, and also identify settings where lncRNAs without obvious endogenous function may serve as therapeutic targets. Harnessing the power of lncRNAomics to impute and perturb lncRNA-dependent regulatory networks, the session will canvass cutting-edge developments in industry, where rational therapeutics targeting lncRNA disease mechanisms are being developed.
Speaker 2 of 6
Frank Rigo, Ionis Pharmaceuticals, USA
Towards a Therapy for Angelman Syndrome by Targeting a Long Noncoding RNA to Active UBE3A

Thursday, March 19 | 5:00PM - 7:30PM
LncRNAs in Human Disease: Toward Rational Ribo-Therapeutics
Room: Grays Peak
This session will survey direct functional evidence implicating lncRNAs as causes of human disease, and also identify settings where lncRNAs without obvious endogenous function may serve as therapeutic targets. Harnessing the power of lncRNAomics to impute and perturb lncRNA-dependent regulatory networks, the session will canvass cutting-edge developments in industry, where rational therapeutics targeting lncRNA disease mechanisms are being developed.
Speaker 3 of 6
James Barsoum, Arrakis Therapeutics, USA
Selective Activation of Gene Expression by Targeting Long Noncoding RNA

Thursday, March 19 | 5:00PM - 7:30PM
LncRNAs in Human Disease: Toward Rational Ribo-Therapeutics
Room: Grays Peak
This session will survey direct functional evidence implicating lncRNAs as causes of human disease, and also identify settings where lncRNAs without obvious endogenous function may serve as therapeutic targets. Harnessing the power of lncRNAomics to impute and perturb lncRNA-dependent regulatory networks, the session will canvass cutting-edge developments in industry, where rational therapeutics targeting lncRNA disease mechanisms are being developed.
Speaker 4 of 6
Saba Valadkhan, Case Western Reserve University, USA
A Bi-Functional Long Noncoding RNA Links Neuronal Differentiation to Survival after Stress

Thursday, March 19 | 5:00PM - 7:30PM
LncRNAs in Human Disease: Toward Rational Ribo-Therapeutics
Room: Grays Peak
This session will survey direct functional evidence implicating lncRNAs as causes of human disease, and also identify settings where lncRNAs without obvious endogenous function may serve as therapeutic targets. Harnessing the power of lncRNAomics to impute and perturb lncRNA-dependent regulatory networks, the session will canvass cutting-edge developments in industry, where rational therapeutics targeting lncRNA disease mechanisms are being developed.
Speaker 5 of 6
Eleonora Leucci, KU Leuven, Belgium
Short Talk: Targeting the Melanoma-Specific Long Noncoding RNA LINC01212 as an Effective Antimelanoma Strategy

Thursday, March 19 | 5:00PM - 7:30PM
LncRNAs in Human Disease: Toward Rational Ribo-Therapeutics
Room: Grays Peak
This session will survey direct functional evidence implicating lncRNAs as causes of human disease, and also identify settings where lncRNAs without obvious endogenous function may serve as therapeutic targets. Harnessing the power of lncRNAomics to impute and perturb lncRNA-dependent regulatory networks, the session will canvass cutting-edge developments in industry, where rational therapeutics targeting lncRNA disease mechanisms are being developed.
Speaker 6 of 6
Claes Wahlestedt, University of Miami/CURNA-OPKO, USA
Long Noncoding RNAs: Therapeutic Opportunities

Thursday, March 19 | 7:30PM - 7:45PM
Concluding Remarks

Speaker 1 of 4
Leonard Lipovich, Wayne State University, USA

Thursday, March 19 | 7:30PM - 7:45PM
Concluding Remarks

Speaker 2 of 4
Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA

Thursday, March 19 | 7:30PM - 7:45PM
Concluding Remarks

Speaker 3 of 4
James (Ben) Brown, Lawrence Berkeley National Laboratory, USA

Thursday, March 19 | 7:30PM - 7:45PM
Concluding Remarks

Speaker 4 of 4
John L. Rinn, University of Colorado Boulder, USA

Thursday, March 19 | 7:45PM - 8:45PM
Social Hour with Lite Bites
Room: Shavano/Torreys
No registration fees are used to fund alcohol served at this function.

Thursday, March 19 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Thursday, March 19 | 8:30PM - 11:00PM
Entertainment
Room: Shavano/Torreys
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Friday, March 20 | 10:25AM - 10:25AM
Departure


*Session Chair.