Web Desc
Pathways of Neurodevelopmental Disorders
Organizer(s): Randi J. Hagerman, Mustafa Sahin and Paul J. Hagerman
Date: March 16 - 20, 2015
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Sponsored by BioLegend, Inc., California Institute for Regenerative Medicine (CIRM), Curemark LLC and FORUM Pharmaceuticals Inc.
Summary of Meeting:
Advances in genetics and animal models for many neurodevelopmental disorders have led to the development of targeted treatments that can reverse neurobiological abnormalities in the animal models. Human studies have begun to show significant benefit from targeted treatments for several neurodevelopmental disorders including fragile X syndrome, tuberous sclerosis, Angelman Syndrome, Down Syndrome, Rett Syndrome and neurofibromatosis, with the potential for many more. There are remarkable commonalities in the dysfunction of key pathways and the molecular mechanisms involved in synaptic plasticity across neurodevelopmental disorders. This Keystone Symposia meeting covers advances in targeted treatments for several neurodevelopmental disorders with an emphasis on common pathways across disorders and treatments that may help more than one disorder. The conference also addresses the gap between how environmental factors including seizures and toxins can impact genetically vulnerable populations, such as those with neurodevelopmental problems, and the molecular mechanisms including mitochondrial dysfunction, oxidative stress, miRNA dysregulation and neuroinflammation that are involved. The goal of this conference is to stimulate development of new treatments and biomarkers to assess treatments in neurodevelopmental disorders and to promote early intervention with prophylactic and targeted treatments. By pulling together basic science and translational clinical trials, and mixing clinicians with molecular biologists and neurobiologists, the meeting should foster new ideas for treatment that will be beneficial across the spectrum of neurodevelopmental disorders.
Scholarship Deadline: November 18 2014
Discounted Abstract Deadline: November 18 2014
Abstract Deadline: December 16 2014
Discounted Registration Deadline: January 15 2015
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
BioLegend, Inc.California Institute for Regenerative Medicine (CIRM)Curemark LLCFORUM Pharmaceuticals Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Institutes for BioMedical Research
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
NeuroscientistNewsS. Karger A.G - Developmental Neuroscience
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS090680-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, March 16 | 4:00PM - 8:00PM
Arrival and Registration
Room: Pre Function


Monday, March 16 | 6:00PM - 8:00PM
Welcome Mixer
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Monday, March 16 | 6:00PM - 8:00PM
Light Meal - Provided by Granlibakken
Room: Granhall


Tuesday, March 17 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, March 17 | 8:00AM - 8:15AM
Welcome Remarks
Room: Mountain/Lake

Speaker 1 of 3
Randi J. Hagerman, University of California, Davis Health System, USA

Tuesday, March 17 | 8:00AM - 8:15AM
Welcome Remarks
Room: Mountain/Lake

Speaker 2 of 3
Mustafa Sahin, Boston Children's Hospital, USA

Tuesday, March 17 | 8:00AM - 8:15AM
Welcome Remarks
Room: Mountain/Lake

Speaker 3 of 3
Paul J. Hagerman, University of California, Davis, USA

Tuesday, March 17 | 8:15AM - 9:15AM
Keynote Address
Room: Mountain/Lake

Speaker 1 of 1
Eric Klann, New York University, USA
Translating Translational Control in Multiple Neurodevelopmental Disorders

Tuesday, March 17 | 9:15AM - 11:45AM
Targeted Treatments
Room: Mountain/Lake

Speaker 1 of 5
* Paul J. Hagerman, University of California, Davis, USA

Tuesday, March 17 | 9:15AM - 11:45AM
Targeted Treatments
Room: Mountain/Lake

Speaker 2 of 5
Mustafa Sahin, Boston Children's Hospital, USA
Targeted Treatments for Tuberous Sclerosis

Tuesday, March 17 | 9:15AM - 11:45AM
Targeted Treatments
Room: Mountain/Lake

Speaker 3 of 5
Walter Kaufmann, Boston Children's Hospital, USA
Targeted Treatments for Rett Syndrome: The IGF-1 Experience

Tuesday, March 17 | 9:15AM - 11:45AM
Targeted Treatments
Room: Mountain/Lake

Speaker 4 of 5
Randi J. Hagerman, University of California, Davis Health System, USA
Targeted Treatments for Fragile X Syndrome

Tuesday, March 17 | 9:15AM - 11:45AM
Targeted Treatments
Room: Mountain/Lake

Speaker 5 of 5
William C. Mobley, University of California, San Diego, USA
Exploring the Biology of Alzheimer Disease in the Context of Down Syndrome

Tuesday, March 17 | 9:40AM - 10:00AM
Coffee Break
Room: Pre Function


Tuesday, March 17 | 11:45AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, March 17 | 11:45AM - 5:00PM
On Own for Lunch


Tuesday, March 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, March 17 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, March 17 | 5:00PM - 7:00PM
Emerging Targeted Treatments
Room: Mountain/Lake

Speaker 1 of 5
* Mriganka Sur, Massachusetts Institute of Technology, USA

Tuesday, March 17 | 5:00PM - 7:00PM
Emerging Targeted Treatments
Room: Mountain/Lake

Speaker 2 of 5
Katherine A. Rauen, University of California, Davis MIND Institute, USA
Treating RASopathies

Tuesday, March 17 | 5:00PM - 7:00PM
Emerging Targeted Treatments
Room: Mountain/Lake

Speaker 3 of 5
Edwin J. Weeber, University of South Florida, USA
Targeted Treatment of Angelman Syndrome

Tuesday, March 17 | 5:00PM - 7:00PM
Emerging Targeted Treatments
Room: Mountain/Lake

Speaker 4 of 5
Stephane J. Baudouin, Cardiff University, UK
Targeting MAP-Kinase Interacting Kinases Restores Protein Synthesis Homeostasis and Improves Behavioral Deficits in Neuroligin-3 Mouse Model of Autism

Tuesday, March 17 | 5:00PM - 7:00PM
Emerging Targeted Treatments
Room: Mountain/Lake

Speaker 5 of 5
Gabriella D'Arcangelo, Rutgers University, USA
Short Talk: Complex Neurological Phenotype in Mutant Mice Lacking Tsc2 in Excitatory Neurons of the Developing Forebrain

Tuesday, March 17 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, March 17 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay


Tuesday, March 17 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Wednesday, March 18 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, March 18 | 8:00AM - 11:15AM
RNA Toxicity and Mitochondrial Dysfunction Across Neurodevel
opmental Disorders

Room: Mountain/Lake
This session reviews the RNA toxicity mechanisms and mitochondrial dysfunction in neurodevelopmental disorders including miRNA dysregulation.
Speaker 1 of 7
* Randi J. Hagerman, University of California, Davis Health System, USA

Wednesday, March 18 | 8:00AM - 11:15AM
RNA Toxicity and Mitochondrial Dysfunction Across Neurodevel
opmental Disorders

Room: Mountain/Lake
This session reviews the RNA toxicity mechanisms and mitochondrial dysfunction in neurodevelopmental disorders including miRNA dysregulation.
Speaker 2 of 7
Paul J. Hagerman, University of California, Davis, USA
RNA Toxicity in Fragile X Premutation Disorders in Development and Aging

Wednesday, March 18 | 8:00AM - 11:15AM
RNA Toxicity and Mitochondrial Dysfunction Across Neurodevel
opmental Disorders

Room: Mountain/Lake
This session reviews the RNA toxicity mechanisms and mitochondrial dysfunction in neurodevelopmental disorders including miRNA dysregulation.
Speaker 3 of 7
Claes Wahlestedt, University of Miami, Miller School of Medicine, USA
Understanding and Drugging the Epigenome

Wednesday, March 18 | 8:00AM - 11:15AM
RNA Toxicity and Mitochondrial Dysfunction Across Neurodevel
opmental Disorders

Room: Mountain/Lake
This session reviews the RNA toxicity mechanisms and mitochondrial dysfunction in neurodevelopmental disorders including miRNA dysregulation.
Speaker 4 of 7
Douglas C. Wallace, Children's Hospital of Philadelphia, USA
A Mitochondrial Dysfunction in Neurodevelpmental Disorders

Wednesday, March 18 | 8:00AM - 11:15AM
RNA Toxicity and Mitochondrial Dysfunction Across Neurodevel
opmental Disorders

Room: Mountain/Lake
This session reviews the RNA toxicity mechanisms and mitochondrial dysfunction in neurodevelopmental disorders including miRNA dysregulation.
Speaker 5 of 7
Gul Dolen, Johns Hopkins University, USA
Social Reward: Basic Mechanisms and Autism Pathogenesis

Wednesday, March 18 | 8:00AM - 11:15AM
RNA Toxicity and Mitochondrial Dysfunction Across Neurodevel
opmental Disorders

Room: Mountain/Lake
This session reviews the RNA toxicity mechanisms and mitochondrial dysfunction in neurodevelopmental disorders including miRNA dysregulation.
Speaker 6 of 7
Koh-ichi Nagata, Institute for Developmental Research, Aichi Human Service Center, Japan
Short Talk: Comprehensive Approach with an Analytical Battery to Understand Pathophysiological Role of A2BP1/RBFOX1, a 'Hub' Gene in the ASD Gene Transcriptome network

Wednesday, March 18 | 8:00AM - 11:15AM
RNA Toxicity and Mitochondrial Dysfunction Across Neurodevel
opmental Disorders

Room: Mountain/Lake
This session reviews the RNA toxicity mechanisms and mitochondrial dysfunction in neurodevelopmental disorders including miRNA dysregulation.
Speaker 7 of 7
Christina Gross, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Crucial Roles of the PI3K Complex Components PIKE and p110beta in Impaired Neuronal Function, Behavior and Cognition in Fragile X Syndrome

Wednesday, March 18 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Wednesday, March 18 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Wednesday, March 18 | 11:15AM - 5:00PM
On Own for Lunch


Wednesday, March 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Wednesday, March 18 | 3:00PM - 4:30PM
Workshop: The Promise of Stem Cell Research for Neurodevelop
mental Disorders. Organized in collaboration with the California Institute for Regenerative Medicine (CIRM)
Room: Mountain/Lake

Speaker 1 of 4
* Mani Vessal, California Institute for Regenerative Medicine, USA

Wednesday, March 18 | 3:00PM - 4:30PM
Workshop: The Promise of Stem Cell Research for Neurodevelop
mental Disorders. Organized in collaboration with the California Institute for Regenerative Medicine (CIRM)
Room: Mountain/Lake

Speaker 2 of 4
Michael F. Clarke, Stanford University, USA
Molecular Regulation of Stem Cells in Down Syndrome

Wednesday, March 18 | 3:00PM - 4:30PM
Workshop: The Promise of Stem Cell Research for Neurodevelop
mental Disorders. Organized in collaboration with the California Institute for Regenerative Medicine (CIRM)
Room: Mountain/Lake

Speaker 3 of 4
Flora M. Vaccarino, Yale University School of Medicine, USA
Modeling Early Cortical Development in Autism Spectrum Disorders Using iPSCs

Wednesday, March 18 | 3:00PM - 4:30PM
Workshop: The Promise of Stem Cell Research for Neurodevelop
mental Disorders. Organized in collaboration with the California Institute for Regenerative Medicine (CIRM)
Room: Mountain/Lake

Speaker 4 of 4
Steve Fancy, University of California, San Francisco, USA
A New Model of Oligodendrocyte Dispersal throughout the Developing CNS

Wednesday, March 18 | 5:00PM - 5:30PM
Coffee Available
Room: Pre Function


Wednesday, March 18 | 5:30PM - 7:15PM
Neurobiological Consequences of Seizures
Room: Mountain/Lake
This session focuses on the neurobiological effects of seizures and their influence on the cognitive and behavioral phenotype of neurodevelopmental disorders.
Speaker 1 of 5
* Eric Klann, New York University, USA

Wednesday, March 18 | 5:30PM - 7:15PM
Neurobiological Consequences of Seizures
Room: Mountain/Lake
This session focuses on the neurobiological effects of seizures and their influence on the cognitive and behavioral phenotype of neurodevelopmental disorders.
Speaker 2 of 5
Nael Burnashev, INSERM, France
Tuberous Sclerosis Complex: A Role of NMDA Receptor Subunits in Early Epilepsy

Wednesday, March 18 | 5:30PM - 7:15PM
Neurobiological Consequences of Seizures
Room: Mountain/Lake
This session focuses on the neurobiological effects of seizures and their influence on the cognitive and behavioral phenotype of neurodevelopmental disorders.
Speaker 3 of 5
Timothy A. Benke, University of Colorado Denver, USA
Early-Life Seizures Cause Latent Synaptic Changes in FMRP-Mediated Signaling, Altered Synaptic Plasticity and an Autistic Phenotype

Wednesday, March 18 | 5:30PM - 7:15PM
Neurobiological Consequences of Seizures
Room: Mountain/Lake
This session focuses on the neurobiological effects of seizures and their influence on the cognitive and behavioral phenotype of neurodevelopmental disorders.
Speaker 4 of 5
Kevin R. Francis, National Institute of Child Health and Human Development, USA
Short Talk: Identification of Neural Phenotypes and Causative Signaling Defects associated with Disorders of Cholesterol Synthesis Using Human iPSCs

Wednesday, March 18 | 5:30PM - 7:15PM
Neurobiological Consequences of Seizures
Room: Mountain/Lake
This session focuses on the neurobiological effects of seizures and their influence on the cognitive and behavioral phenotype of neurodevelopmental disorders.
Speaker 5 of 5
Seung Tae Baek, Rockefeller University, USA
Short Talk: An AKT3-FOXG1-Reelin Network Underlies Human Focal Malformations of Cortical Development

Wednesday, March 18 | 7:15PM - 8:15PM
Dinner
Room: Granhall


Wednesday, March 18 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay


Wednesday, March 18 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Thursday, March 19 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, March 19 | 8:00AM - 11:15AM
Epigenetic Changes and Environmental Toxicity in Neurodevelo
pmental Disorders

Room: Mountain/Lake
This session explores epigenetic changes in neurodevelopmental disorders and the influence of environmental toxicity.
Speaker 1 of 7
* Randi J. Hagerman, University of California, Davis Health System, USA

Thursday, March 19 | 8:00AM - 11:15AM
Epigenetic Changes and Environmental Toxicity in Neurodevelo
pmental Disorders

Room: Mountain/Lake
This session explores epigenetic changes in neurodevelopmental disorders and the influence of environmental toxicity.
Speaker 2 of 7
Mriganka Sur, Massachusetts Institute of Technology, USA
Signaling and Circuit Mechanisms of Rett Syndrome

Thursday, March 19 | 8:00AM - 11:15AM
Epigenetic Changes and Environmental Toxicity in Neurodevelo
pmental Disorders

Room: Mountain/Lake
This session explores epigenetic changes in neurodevelopmental disorders and the influence of environmental toxicity.
Speaker 3 of 7
Isaac N. Pessah, University of California, Davis, USA
Tipping the Balance of Neural Circuits during Neurodevelopment: Toward Understanding Convergent Mechanisms from Genes and Environment


Thursday, March 19 | 8:00AM - 11:15AM
Epigenetic Changes and Environmental Toxicity in Neurodevelo
pmental Disorders

Room: Mountain/Lake
This session explores epigenetic changes in neurodevelopmental disorders and the influence of environmental toxicity.
Speaker 4 of 7
Anne E. West, Duke University Medical Center, USA
Epigenomic Regulation of Neuronal Differentiation

Thursday, March 19 | 8:00AM - 11:15AM
Epigenetic Changes and Environmental Toxicity in Neurodevelo
pmental Disorders

Room: Mountain/Lake
This session explores epigenetic changes in neurodevelopmental disorders and the influence of environmental toxicity.
Speaker 5 of 7
Zhaolan (Joe) Zhou, University of Pennsylvania, USA
Understanding the Role of Methyl-CpG Binding Domain Proteins in the Etiology of Autism Spectrum Disorders

Thursday, March 19 | 8:00AM - 11:15AM
Epigenetic Changes and Environmental Toxicity in Neurodevelo
pmental Disorders

Room: Mountain/Lake
This session explores epigenetic changes in neurodevelopmental disorders and the influence of environmental toxicity.
Speaker 6 of 7
Hyang Mi Moon, Stanford University, USA
Short Talk: Interaction between GABRB3 Haploinsufficiency and Gestational Lipopolysaccharide Exposure Exacerbates Placental Vulnerability

Thursday, March 19 | 8:00AM - 11:15AM
Epigenetic Changes and Environmental Toxicity in Neurodevelo
pmental Disorders

Room: Mountain/Lake
This session explores epigenetic changes in neurodevelopmental disorders and the influence of environmental toxicity.
Speaker 7 of 7
T. Peter Stein, Rowan University, USA
Short Talk: Bisphenol A (BPA) and Autism Spectrum Disorders

Thursday, March 19 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Thursday, March 19 | 11:15AM - 5:00PM
On Own for Lunch


Thursday, March 19 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Thursday, March 19 | 5:00PM - 6:45PM
Emerging New Treatments and Biomarkers
Room: Mountain/Lake
This session focuses on new targeted treatments for neurodevelopmental disorders and potential biomarkers to be used in treatment studies.
Speaker 1 of 4
* Mustafa Sahin, Boston Children's Hospital, USA

Thursday, March 19 | 5:00PM - 6:45PM
Emerging New Treatments and Biomarkers
Room: Mountain/Lake
This session focuses on new targeted treatments for neurodevelopmental disorders and potential biomarkers to be used in treatment studies.
Speaker 2 of 4
Flora Tassone, University of California, Davis, USA
Biomarkers for Targeted Treatments in Fragile X Syndrome and Associated Disorders

Thursday, March 19 | 5:00PM - 6:45PM
Emerging New Treatments and Biomarkers
Room: Mountain/Lake
This session focuses on new targeted treatments for neurodevelopmental disorders and potential biomarkers to be used in treatment studies.
Speaker 3 of 4
Jason Arsenault, University of Toronto, Canada
Short Talk: Adeno-Associated Viral Vector-Mediated Gene Therapy Strategies to Treat Fragile X Syndrome

Thursday, March 19 | 5:00PM - 6:45PM
Emerging New Treatments and Biomarkers
Room: Mountain/Lake
This session focuses on new targeted treatments for neurodevelopmental disorders and potential biomarkers to be used in treatment studies.
Speaker 4 of 4
Samuel S.-H. Wang, Princeton University, USA
New Technologies for Probing Sensitive-Period Influences in Brain Development

Thursday, March 19 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Mountain/Lake


Thursday, March 19 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Thursday, March 19 | 7:00PM - 8:00PM
Social Hour
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Thursday, March 19 | 8:00PM - 11:00PM
Entertainment
Room: Granhall
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, March 19 | 8:00PM - 11:00PM
Cash Bar
Room: Granhall


Friday, March 20 | 10:25AM - 10:25AM
Departure


*Session Chair.