Web Desc
Gram-Negative Resistance
Organizer(s): Robert E.W. Hancock and Eric D. Brown
Date: March 29 - April 02, 2015
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Sponsored by Merck & Co., Inc. and Sarepta Therapeutics
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Summary of Meeting:
SIGNIFICANCE: The antibiotic era, stemming from the deployment of penicillin, introduced arguably the most successful medicines of all time, impacting dramatically on life expectancy by decreasing childhood and adult deaths from infections, and enabling complex surgeries, transplantations and cancer chemotherapy. However the therapy of infectious diseases is now under severe threat. There has been an explosion of resistance to antibiotics, whereby our entire arsenal of antibiotics is gradually losing effectiveness. This is particularly acute for Gram negative bacteria since there are few new antibiotics or strategies in the development pipeline. In this meeting we will address the major issues and potential solutions to this crisis. INNOVATION: The issues associated with gram-negative resistance, and the design of effective therapeutics, are different and more complicated than those associated with the other major division of bacteria (gram positives). Consistent with the most recent antibiotics are active against the latter class leaving academic and company researchers and physicians to wonder where the next generation of treatments will come from. For this reason, it is essential that these issues are discussed as a distinct problem that has the potential to unravel human medical successes. Here, we will bring together diverse researchers from disciplines ranging from discovery research to drug development and clinical treatment to discuss strategies for addressing this critical issue and proposing routes for innovative solutions.
Scholarship Deadline: December 1 2014
Discounted Abstract Deadline: December 1 2014
Abstract Deadline: January 6 2015
Discounted Registration Deadline: January 27 2015
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Merck & Co., Inc.Sarepta Therapeutics
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

AstraZeneca Pharmaceuticals, L.P.

MedImmune

Pfizer Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Center for Structural Genomics of Infectious DiseasesSeattle Structural Genomics Center for Infectious Disease
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI115778-01
Funding for this conference was made possible [in part] by 1 R13 AI 115778-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 29 | 4:00PM - 8:00PM
Arrival and Registration
Room: Pre Function


Sunday, March 29 | 6:00PM - 8:00PM
Welcome Mixer
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Sunday, March 29 | 6:00PM - 8:00PM
Light Meal - Provided by Granlibakken
Room: Granhall


Monday, March 30 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, March 30 | 8:00AM - 9:00AM
Keynote Address
Room: Mountain/Lake

Speaker 1 of 1
Brad Spellberg, LAC, University of Southern California Medical Center, USA
The Future of Antibiotics and Resistance

Monday, March 30 | 9:00AM - 11:15AM
Gram-Negative Drug Resistance - A Complex Problem
Room: Mountain/Lake

Speaker 1 of 5
* Gerry D. Wright, McMaster University, Canada

Monday, March 30 | 9:00AM - 11:15AM
Gram-Negative Drug Resistance - A Complex Problem
Room: Mountain/Lake

Speaker 2 of 5
José L. Martínez, Centro Nacional de Biotecnologia, CSIC, Spain
The Resistome; Definition, Identification, Tools and Implications

Monday, March 30 | 9:00AM - 11:15AM
Gram-Negative Drug Resistance - A Complex Problem
Room: Mountain/Lake

Speaker 3 of 5
Kim Lewis, Northeastern University, USA
Interplay between Resistance and Tolerance

Monday, March 30 | 9:00AM - 11:15AM
Gram-Negative Drug Resistance - A Complex Problem
Room: Mountain/Lake

Speaker 4 of 5
Diarmaid P. Hughes, Uppsala University, Sweden
Selection of Resistance at Lethal and Non-Lethal Antibiotic Concentrations

Monday, March 30 | 9:00AM - 11:15AM
Gram-Negative Drug Resistance - A Complex Problem
Room: Mountain/Lake

Speaker 5 of 5
Lori L. Burrows, McMaster University, Canada
Short Talk: Agents Provocateur: Stimulation of Biofilm Formation by Bioactive Small Molecules

Monday, March 30 | 9:40AM - 10:00AM
Coffee Break
Room: Pre Function


Monday, March 30 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Monday, March 30 | 11:15AM - 5:00PM
On Own for Lunch


Monday, March 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Monday, March 30 | 2:30PM - 4:30PM
Workshop on Structure-Guided Antibiotic Development
Room: Mountain/Lake
Workshop Faculty representing the following centers:

CSGID: Center for Structural Genomics of Infectious Disease

SSGCID: Seattle Structural Genomics Center for Infectious Diseases

DRGN: Structure-­guided drug discovery coalition
for drug-­resistant gram-­negative organisms

SGCID: Structural Genomic Centers of Infectious Diseases (CSGID & SSGCID)

ENABLE: The European Gram Negative Anti-Bacterial Engine project within IMI's 'New Drugs for Bad Bugs' (ND4BB) programme

SDDC: Structure-­guided Drug Discovery Coalition for tuberculosis and malaria

MCSG: Midwest Center for Structural Genomics
Speaker 1 of 7
* Alexei Savchenko, University of Calgary, Canada

Monday, March 30 | 2:30PM - 4:30PM
Workshop on Structure-Guided Antibiotic Development
Room: Mountain/Lake
Workshop Faculty representing the following centers:

CSGID: Center for Structural Genomics of Infectious Disease

SSGCID: Seattle Structural Genomics Center for Infectious Diseases

DRGN: Structure-­guided drug discovery coalition
for drug-­resistant gram-­negative organisms

SGCID: Structural Genomic Centers of Infectious Diseases (CSGID & SSGCID)

ENABLE: The European Gram Negative Anti-Bacterial Engine project within IMI's 'New Drugs for Bad Bugs' (ND4BB) programme

SDDC: Structure-­guided Drug Discovery Coalition for tuberculosis and malaria

MCSG: Midwest Center for Structural Genomics
Speaker 2 of 7
Peter J. Myler, Seattle Biomedical Research Institute, USA
Introduction and Overview, including Vision for DRGN

Monday, March 30 | 2:30PM - 4:30PM
Workshop on Structure-Guided Antibiotic Development
Room: Mountain/Lake
Workshop Faculty representing the following centers:

CSGID: Center for Structural Genomics of Infectious Disease

SSGCID: Seattle Structural Genomics Center for Infectious Diseases

DRGN: Structure-­guided drug discovery coalition
for drug-­resistant gram-­negative organisms

SGCID: Structural Genomic Centers of Infectious Diseases (CSGID & SSGCID)

ENABLE: The European Gram Negative Anti-Bacterial Engine project within IMI's 'New Drugs for Bad Bugs' (ND4BB) programme

SDDC: Structure-­guided Drug Discovery Coalition for tuberculosis and malaria

MCSG: Midwest Center for Structural Genomics
Speaker 3 of 7
Wayne F. Anderson, Northwestern University Medical School, USA
The SGCISs, Impact on Gram Negatives

Monday, March 30 | 2:30PM - 4:30PM
Workshop on Structure-Guided Antibiotic Development
Room: Mountain/Lake
Workshop Faculty representing the following centers:

CSGID: Center for Structural Genomics of Infectious Disease

SSGCID: Seattle Structural Genomics Center for Infectious Diseases

DRGN: Structure-­guided drug discovery coalition
for drug-­resistant gram-­negative organisms

SGCID: Structural Genomic Centers of Infectious Diseases (CSGID & SSGCID)

ENABLE: The European Gram Negative Anti-Bacterial Engine project within IMI's 'New Drugs for Bad Bugs' (ND4BB) programme

SDDC: Structure-­guided Drug Discovery Coalition for tuberculosis and malaria

MCSG: Midwest Center for Structural Genomics
Speaker 4 of 7
Robert Stavenger, GlaxoSmithKline, USA
Current European Collaborative Plans, ENABLE

Monday, March 30 | 2:30PM - 4:30PM
Workshop on Structure-Guided Antibiotic Development
Room: Mountain/Lake
Workshop Faculty representing the following centers:

CSGID: Center for Structural Genomics of Infectious Disease

SSGCID: Seattle Structural Genomics Center for Infectious Diseases

DRGN: Structure-­guided drug discovery coalition
for drug-­resistant gram-­negative organisms

SGCID: Structural Genomic Centers of Infectious Diseases (CSGID & SSGCID)

ENABLE: The European Gram Negative Anti-Bacterial Engine project within IMI's 'New Drugs for Bad Bugs' (ND4BB) programme

SDDC: Structure-­guided Drug Discovery Coalition for tuberculosis and malaria

MCSG: Midwest Center for Structural Genomics
Speaker 5 of 7
Gerry D. Wright, McMaster University, Canada
A Model for North American Cooperation in Protein Structure-Function Studies of Antibiotic Resistance

Monday, March 30 | 2:30PM - 4:30PM
Workshop on Structure-Guided Antibiotic Development
Room: Mountain/Lake
Workshop Faculty representing the following centers:

CSGID: Center for Structural Genomics of Infectious Disease

SSGCID: Seattle Structural Genomics Center for Infectious Diseases

DRGN: Structure-­guided drug discovery coalition
for drug-­resistant gram-­negative organisms

SGCID: Structural Genomic Centers of Infectious Diseases (CSGID & SSGCID)

ENABLE: The European Gram Negative Anti-Bacterial Engine project within IMI's 'New Drugs for Bad Bugs' (ND4BB) programme

SDDC: Structure-­guided Drug Discovery Coalition for tuberculosis and malaria

MCSG: Midwest Center for Structural Genomics
Speaker 6 of 7
Chris Walpole, SGC, University of Toronto, Canada
The SDDC as a Collaborative Drug Discovery Model

Monday, March 30 | 2:30PM - 4:30PM
Workshop on Structure-Guided Antibiotic Development
Room: Mountain/Lake
Workshop Faculty representing the following centers:

CSGID: Center for Structural Genomics of Infectious Disease

SSGCID: Seattle Structural Genomics Center for Infectious Diseases

DRGN: Structure-­guided drug discovery coalition
for drug-­resistant gram-­negative organisms

SGCID: Structural Genomic Centers of Infectious Diseases (CSGID & SSGCID)

ENABLE: The European Gram Negative Anti-Bacterial Engine project within IMI's 'New Drugs for Bad Bugs' (ND4BB) programme

SDDC: Structure-­guided Drug Discovery Coalition for tuberculosis and malaria

MCSG: Midwest Center for Structural Genomics
Speaker 7 of 7
Jane M. Knisely, NIAID, National Institutes of Health, USA
NIAID Resources for Antibacterial Product Development

Monday, March 30 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, March 30 | 5:00PM - 7:00PM
Emerging Threats in Gram-Negative Drug Resistance
Room: Mountain/Lake

Speaker 1 of 5
* Lori L. Burrows, McMaster University, Canada

Monday, March 30 | 5:00PM - 7:00PM
Emerging Threats in Gram-Negative Drug Resistance
Room: Mountain/Lake

Speaker 2 of 5
David M. Livermore, University of East Anglia, UK
Gram-Negatives: A Hydra-Headed Threat

Monday, March 30 | 5:00PM - 7:00PM
Emerging Threats in Gram-Negative Drug Resistance
Room: Mountain/Lake

Speaker 3 of 5
Karen Bush, Indiana University, USA
Updates on Beta-Lactam Resistance in Gram-Negative Pathogens

Monday, March 30 | 5:00PM - 7:00PM
Emerging Threats in Gram-Negative Drug Resistance
Room: Mountain/Lake

Speaker 4 of 5
Jian Li, Monash University, Australia
Polymyxins: Never a Failure, Always a Lesson

Monday, March 30 | 5:00PM - 7:00PM
Emerging Threats in Gram-Negative Drug Resistance
Room: Mountain/Lake

Speaker 5 of 5
Daniel J. Dwyer, University of Maryland, College Park, USA
Short Talk: Targeting Emergent Cell Death Phenomena and Physiological Instability Induced by Antibiotics to Uncover Novel Therapeutic Strategies

Monday, March 30 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, March 30 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay


Monday, March 30 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Tuesday, March 31 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, March 31 | 8:00AM - 9:20AM
Gram-Negative Drug Development - The Future
Room: Mountain/Lake

Speaker 1 of 3
* Karen Bush, Indiana University, USA

Tuesday, March 31 | 8:00AM - 9:20AM
Gram-Negative Drug Development - The Future
Room: Mountain/Lake

Speaker 2 of 3
Sumathi Nambiar, U.S. Food and Drug Administration, USA
Regulatory Perspective on Drug Development Programs for Gram-Negative Infections

Tuesday, March 31 | 8:00AM - 9:20AM
Gram-Negative Drug Development - The Future
Room: Mountain/Lake

Speaker 3 of 3
Robert Stavenger, GlaxoSmithKline, USA
IMI Translocation: A PPP Approach to Understanding Gram-Negative Penetration

Tuesday, March 31 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Tuesday, March 31 | 9:40AM - 11:15AM
New Approaches in Gram-Negative Small Molecule Drug Discover
y

Room: Mountain/Lake

Speaker 1 of 4
* Daniel J. Dwyer, University of Maryland, College Park, USA

Tuesday, March 31 | 9:40AM - 11:15AM
New Approaches in Gram-Negative Small Molecule Drug Discover
y

Room: Mountain/Lake

Speaker 2 of 4
Eric D. Brown, McMaster University, Canada
Starving Bacteria to Find New Antibiotics

Tuesday, March 31 | 9:40AM - 11:15AM
New Approaches in Gram-Negative Small Molecule Drug Discover
y

Room: Mountain/Lake

Speaker 3 of 4
Dustin T. King, University of British Columbia, Canada

Tuesday, March 31 | 9:40AM - 11:15AM
New Approaches in Gram-Negative Small Molecule Drug Discover
y

Room: Mountain/Lake

Speaker 4 of 4
Wright W. Nichols, AstraZeneca R&D Boston, USA
Target-Based Drug Discovery: Where Next?

Tuesday, March 31 | 11:15AM - 1:00PM
Poster Setup
Room: Bay


Tuesday, March 31 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, March 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay


Tuesday, March 31 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, March 31 | 5:00PM - 7:00PM
Permeability and Efflux
Room: Mountain/Lake

Speaker 1 of 5
* Robert E.W. Hancock, University of British Columbia, Canada

Tuesday, March 31 | 5:00PM - 7:00PM
Permeability and Efflux
Room: Mountain/Lake

Speaker 2 of 5
R. Keith Poole, Queen's University, Canada
Multidrug Efflux Systems as Components of Stress Responses in Pseudomonas aeruginosa

Tuesday, March 31 | 5:00PM - 7:00PM
Permeability and Efflux
Room: Mountain/Lake

Speaker 3 of 5
Mathias Winterhalter, Jacobs University Bremen, Germany
Quantification of Antibiotic Uptake Across Bacterial Cell Walls

Tuesday, March 31 | 5:00PM - 7:00PM
Permeability and Efflux
Room: Mountain/Lake

Speaker 4 of 5
Helen I. Zgurskaya, University of Oklahoma, USA
Multi-Drug Efflux in the Context of Two Membranes

Tuesday, March 31 | 5:00PM - 7:00PM
Permeability and Efflux
Room: Mountain/Lake

Speaker 5 of 5
Thien-Fah Mah, University of Ottawa, Canada
Short Talk: Identification of a Novel Transcriptional Regulator of Antibiotic Resistance in Pseudomonas aeruginosa

Tuesday, March 31 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, March 31 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay


Tuesday, March 31 | 8:00PM - 9:00PM
Social Hour
Room: Bay
No registration fees are used to fund alcohol served at this function.

Wednesday, April 01 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, April 01 | 8:00AM - 11:00AM
Alternatives to Small Molecule Antibiotics - Targeting the H
ost

Room: Mountain/Lake

Speaker 1 of 6
* Helen I. Zgurskaya, University of Oklahoma, USA

Wednesday, April 01 | 8:00AM - 11:00AM
Alternatives to Small Molecule Antibiotics - Targeting the H
ost

Room: Mountain/Lake

Speaker 2 of 6
Robert E.W. Hancock, University of British Columbia, Canada
Targeting the Host

Wednesday, April 01 | 8:00AM - 11:00AM
Alternatives to Small Molecule Antibiotics - Targeting the H
ost

Room: Mountain/Lake

Speaker 3 of 6
Laurence Rahme, Massachusetts General Hospital, USA
Anti-Virulence Approaches against Acute and Persistent/Relapsing Pseudomonas aeruginosa Infections

Wednesday, April 01 | 8:00AM - 11:00AM
Alternatives to Small Molecule Antibiotics - Targeting the H
ost

Room: Mountain/Lake

Speaker 4 of 6
Charles Ken Stover, MedImmune, LLC, USA
Targeting Serious Bacterial Infections with New Antibody-Based Strategies

Wednesday, April 01 | 8:00AM - 11:00AM
Alternatives to Small Molecule Antibiotics - Targeting the H
ost

Room: Mountain/Lake

Speaker 5 of 6
David A. Putnam, Cornell University, USA
Recombinant Bacterial Outer Membrane Vesicles for Subunit Vaccine Modulation

Wednesday, April 01 | 8:00AM - 11:00AM
Alternatives to Small Molecule Antibiotics - Targeting the H
ost

Room: Mountain/Lake

Speaker 6 of 6
Andrew Nelson Gray, University of California, San Francisco, USA
Short Talk: The Careful Coordination of Envelope Constriction Processes Required for Maintaining Cell Integrity Are Points of Vulnerability Susceptible to Disruption

Wednesday, April 01 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Wednesday, April 01 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, April 01 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, April 01 | 5:00PM - 6:45PM
Natural Products – Time for a Comeback
Room: Mountain/Lake

Speaker 1 of 4
* Eric D. Brown, McMaster University, Canada

Wednesday, April 01 | 5:00PM - 6:45PM
Natural Products – Time for a Comeback
Room: Mountain/Lake

Speaker 2 of 4
Adam C. Palmer, Harvard Medical School, USA
Evolutionary Insights into Antibiotic Mechanisms

Wednesday, April 01 | 5:00PM - 6:45PM
Natural Products – Time for a Comeback
Room: Mountain/Lake

Speaker 3 of 4
Gerry D. Wright, McMaster University, Canada
Natural Products to Reverse Drug Resistance in Gram Negative Pathogens

Wednesday, April 01 | 5:00PM - 6:45PM
Natural Products – Time for a Comeback
Room: Mountain/Lake

Speaker 4 of 4
Roger G. Linington, USA
Activity Profile Screening: High Content Screening Approaches to Natural Product Antibiotic Discovery

Wednesday, April 01 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Mountain/Lake


Wednesday, April 01 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Wednesday, April 01 | 7:00PM - 8:00PM
Social Hour
Room: Granhall
No registration fees are used to fund alcohol served at this function.

Wednesday, April 01 | 8:00PM - 11:00PM
Entertainment
Room: Granhall
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, April 02 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.