Web Desc
Beige and Brown Fat: Basic Biology and Novel Therapeutics
Organizer(s): Bruce M. Spiegelman and Sven Enerbäck
Date: April 17 - 22, 2015
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by AstraZeneca
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Summary of Meeting:
The epidemic of obesity and diabetes has become a world-wide health risk. These metabolic disorders are a direct threat to the health and economic well-being of many nations. Unfortunately, education about diet and exercise are not sufficient to meet this emergency and new therapies are badly needed. Brown fat has emerged as one of the few genuinely new approaches to these problems. Brown fat exists in most or all adult humans and can dissipate caloric energy and improve both obesity and diabetes in experimental animals. This meeting will focus on new pathways controlling brown fat development and thermogenesis. We will delve into the types of brown fat cells, beige, classical brown and others. We will also put a special emphasis on emerging approaches, both biological and chemical, that can manipulate these cells for therapeutic purposes. It is our hope and belief that this meeting can nucleate expanded efforts in both academia and pharma to explore this promising research area. There has not been a Keystone Symposia conference dedicated to brown fat. While there has been a session here and there at the Obesity meeting, the science and the biomedical needs warrant this new and focused conference. Of course, this will also bridge the Obesity and Diabetes communities, and lead to pharma/academic collaborations.
Scholarship Deadline: December 16 2014
Discounted Abstract Deadline: December 16 2014
Abstract Deadline: January 15 2015
Discounted Registration Deadline: February 18 2015
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZeneca
We gratefully acknowledge additional support for this conference from:
Adipogen InternationalAvanti Polar Lipids, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Ember Therapeutics
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13DK104499-01
Funding for this conference was made possible (in part) by 1 R13 DK104499-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, April 17 | 4:00PM - 8:00PM
Arrival and Registration
Room: Ballroom Lobby


Friday, April 17 | 6:00PM - 8:00PM
Welcome Mixer
Room: Ballroom Lobby
No registration fees are used to fund alcohol served at this function.

Saturday, April 18 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Saturday, April 18 | 8:00AM - 8:15AM
Welcome Remarks
Room: Ballroom 2-3

Speaker 1 of 2
Bruce M. Spiegelman, Harvard Medical School, USA

Saturday, April 18 | 8:00AM - 8:15AM
Welcome Remarks
Room: Ballroom 2-3

Speaker 2 of 2
Sven Enerbäck, University of Gothenburg, Sweden

Saturday, April 18 | 8:15AM - 9:15AM
Keynote Address
Room: Ballroom 2-3

Speaker 1 of 2
* Bruce M. Spiegelman, Harvard Medical School, USA

Saturday, April 18 | 8:15AM - 9:15AM
Keynote Address
Room: Ballroom 2-3

Speaker 2 of 2
Vamsi K. Mootha, Massachusetts General Hospital, USA
A Systems Approach to Mitochondrial Bioenergetics

Saturday, April 18 | 9:15AM - 11:30AM
Brown and Beige: Lineage and Development I
Room: Ballroom 2-3
Lineage and development of brown fat cells.
Speaker 1 of 4
Patrick Seale, University of Pennsylvania, USA
Transcriptional Control of Brown and Beige Fat Cell Fate

Saturday, April 18 | 9:15AM - 11:30AM
Brown and Beige: Lineage and Development I
Room: Ballroom 2-3
Lineage and development of brown fat cells.
Speaker 2 of 4
James G. Granneman, Wayne State University School of Medicine, USA
Mechanisms of Brown Adipocyte Recruitment by Adrenergic Receptor Activation in Vivo

Saturday, April 18 | 9:15AM - 11:30AM
Brown and Beige: Lineage and Development I
Room: Ballroom 2-3
Lineage and development of brown fat cells.
Speaker 3 of 4
* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
De Novo Birth of Beige Fat Cells

Saturday, April 18 | 9:15AM - 11:30AM
Brown and Beige: Lineage and Development I
Room: Ballroom 2-3
Lineage and development of brown fat cells.
Speaker 4 of 4
Jacob M. McGlashon, University of Iowa, USA
Short Talk: Pet-1+ Serotonin Neurons Induce White Adipose Browning, Activate Brown Adipose and Are Required for Metabolic Homeostasis

Saturday, April 18 | 9:40AM - 10:00AM
Coffee Break
Room: Ballroom Lobby


Saturday, April 18 | 11:30AM - 1:00PM
Poster Setup
Room: Ballroom 1


Saturday, April 18 | 11:30AM - 5:00PM
On Own for Lunch


Saturday, April 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom 1


Saturday, April 18 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Saturday, April 18 | 5:00PM - 7:00PM
Brown and Beige: Lineage and Development II
Room: Ballroom 2-3
Lineage and development of brown fat cells.
Speaker 1 of 4
* Barbara Cannon, Stockholm University, Sweden
White, Beige/Brite and Brown Adipocytes

Saturday, April 18 | 5:00PM - 7:00PM
Brown and Beige: Lineage and Development II
Room: Ballroom 2-3
Lineage and development of brown fat cells.
Speaker 2 of 4
Stephan Herzig, Helmholtz Zentrum München, Germany
Transcriptional Co-Factor Loops in BAT Activation and Systemic Energy Balance

Saturday, April 18 | 5:00PM - 7:00PM
Brown and Beige: Lineage and Development II
Room: Ballroom 2-3
Lineage and development of brown fat cells.
Speaker 3 of 4
Saverio Cinti, University of Ancona, Italy
White, Brown and Pink Adipocytes: The Extraordinary Plasticity of the Adipose Organ

Saturday, April 18 | 5:00PM - 7:00PM
Brown and Beige: Lineage and Development II
Room: Ballroom 2-3
Lineage and development of brown fat cells.
Speaker 4 of 4
Jeremie Boucher, AstraZeneca, Sweden
Short Talk: Identification of Compounds Inducing UCP1 in Differentiating Human White Preadipocytes

Saturday, April 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 1
No registration fees are used to fund alcohol served at this function.

Saturday, April 18 | 7:30PM - 10:00PM
Poster Session 1
Room: Ballroom 1


Sunday, April 19 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Sunday, April 19 | 8:00AM - 11:15AM
Transcriptional Control of Brown Fat I
Room: Ballroom 2-3
Transcriptional control of brown fat and the thermogenic gene program.
Speaker 1 of 6
Shingo Kajimura, University of California, San Francisco, USA
Pharmacological Approaches to Promote Beige Adipocyte Development

Sunday, April 19 | 8:00AM - 11:15AM
Transcriptional Control of Brown Fat I
Room: Ballroom 2-3
Transcriptional control of brown fat and the thermogenic gene program.
Speaker 2 of 6
Bruce M. Spiegelman, Harvard Medical School, USA
Regulation of Heat Production by Various Shades of Fat: A Novel Thermogenic Pathway in Beige Fat

Sunday, April 19 | 8:00AM - 11:15AM
Transcriptional Control of Brown Fat I
Room: Ballroom 2-3
Transcriptional control of brown fat and the thermogenic gene program.
Speaker 3 of 6
* Stephen R. Farmer, Boston University School of Medicine, USA
Novel Signaling/Transcriptional Pathways Regulating Conversion of Progenitors to Beige/Brite Adipocytes

Sunday, April 19 | 8:00AM - 11:15AM
Transcriptional Control of Brown Fat I
Room: Ballroom 2-3
Transcriptional control of brown fat and the thermogenic gene program.
Speaker 4 of 6
Domenico Accili, Columbia University, USA
Sirtuins and Brown Fat Development

Sunday, April 19 | 8:00AM - 11:15AM
Transcriptional Control of Brown Fat I
Room: Ballroom 2-3
Transcriptional control of brown fat and the thermogenic gene program.
Speaker 5 of 6
Ann Marie Hammarstedt, Lundberg Laboratory for Diabetes Research, Sweden
Short Talk: BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

Sunday, April 19 | 8:00AM - 11:15AM
Transcriptional Control of Brown Fat I
Room: Ballroom 2-3
Transcriptional control of brown fat and the thermogenic gene program.
Speaker 6 of 6
Carol Renfrew Haft, NIDDK, National Institutes of Health, USA
Short Talk: Funding Opportunities

Sunday, April 19 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Sunday, April 19 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom 1


Sunday, April 19 | 11:00AM - 5:00PM
On Own for Lunch


Sunday, April 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom 1


Sunday, April 19 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Sunday, April 19 | 5:00PM - 7:00PM
Transcriptional Control of Brown Fat II
Room: Ballroom 2-3
Transcriptional control of brown fat and the thermogenic gene program.
Speaker 1 of 4
* Ajay Chawla, Merck and University of California, San Francisco, USA
Innate Control of Thermogenesis

Sunday, April 19 | 5:00PM - 7:00PM
Transcriptional Control of Brown Fat II
Room: Ballroom 2-3
Transcriptional control of brown fat and the thermogenic gene program.
Speaker 2 of 4
Alan R. Saltiel, University of California, San Diego, USA
Inflammation and Energy Homeostasis

Sunday, April 19 | 5:00PM - 7:00PM
Transcriptional Control of Brown Fat II
Room: Ballroom 2-3
Transcriptional control of brown fat and the thermogenic gene program.
Speaker 3 of 4
Laurie J. Goodyear, Joslin Diabetes Center, Harvard Medical School, USA
Exercise Regulation of Beige and Brown Fat

Sunday, April 19 | 5:00PM - 7:00PM
Transcriptional Control of Brown Fat II
Room: Ballroom 2-3
Transcriptional control of brown fat and the thermogenic gene program.
Speaker 4 of 4
Matthew T. Andrews, University of Minnesota, USA
Short Talk: Integrating Molecular and Functional Analysis of Brown Adipose Tissue across the Physiological Extremes of Natural Hibernation

Sunday, April 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 1
No registration fees are used to fund alcohol served at this function.

Sunday, April 19 | 7:30PM - 10:00PM
Poster Session 2
Room: Ballroom 1


Monday, April 20 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, April 20 | 8:00AM - 11:00AM
Human BAT and Therapeutic Modulation I
Room: Ballroom 2-3
The types of human BAT and how their functions and amounts can be modulated.
Speaker 1 of 6
* Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA

Monday, April 20 | 8:00AM - 11:00AM
Human BAT and Therapeutic Modulation I
Room: Ballroom 2-3
The types of human BAT and how their functions and amounts can be modulated.
Speaker 2 of 6
Sven Enerbäck, University of Gothenburg, Sweden
Human Brown Adipose Tissue

Monday, April 20 | 8:00AM - 11:00AM
Human BAT and Therapeutic Modulation I
Room: Ballroom 2-3
The types of human BAT and how their functions and amounts can be modulated.
Speaker 3 of 6
Aaron M. Cypess, NIDDK, National Institutes of Health, USA
The Responses of Human Brown, Beige and White Fat to Pharmacological Stimulation

Monday, April 20 | 8:00AM - 11:00AM
Human BAT and Therapeutic Modulation I
Room: Ballroom 2-3
The types of human BAT and how their functions and amounts can be modulated.
Speaker 4 of 6
Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
FGF21: Regulating the Fuel and the Fire of Metabolism

Monday, April 20 | 8:00AM - 11:00AM
Human BAT and Therapeutic Modulation I
Room: Ballroom 2-3
The types of human BAT and how their functions and amounts can be modulated.
Speaker 5 of 6
Wouter D. van Marken Lichtenbelt, Maastricht University, Netherlands
Recruitment of Human Brown and Beige Fat

Monday, April 20 | 8:00AM - 11:00AM
Human BAT and Therapeutic Modulation I
Room: Ballroom 2-3
The types of human BAT and how their functions and amounts can be modulated.
Speaker 6 of 6
Kirsi A. Virtanen, Turku University Hospital, University of Turku, Finland
Short Talk: Fatty Acids Taken Up by Activated Human Brown Adipose Tissue Are Mainly Oxidized

Monday, April 20 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Monday, April 20 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom 1


Monday, April 20 | 11:00AM - 5:00PM
On Own for Lunch


Monday, April 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom 1


Monday, April 20 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Monday, April 20 | 5:00PM - 7:00PM
Human BAT and Therapeutic Modulation II
Room: Ballroom 2-3
The types of human BAT and how their functions and amounts can be modulated.
Speaker 1 of 5
* Sven Enerbäck, University of Gothenburg, Sweden

Monday, April 20 | 5:00PM - 7:00PM
Human BAT and Therapeutic Modulation II
Room: Ballroom 2-3
The types of human BAT and how their functions and amounts can be modulated.
Speaker 2 of 5
Masayuki Saito, Tenshi College, Japan
Brown Adipose Tissue as a Therapeutic Target for Human Obesity

Monday, April 20 | 5:00PM - 7:00PM
Human BAT and Therapeutic Modulation II
Room: Ballroom 2-3
The types of human BAT and how their functions and amounts can be modulated.
Speaker 3 of 5
Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA
Deciphering Human Brown Adipogenesis by Functional and Clonal Analyses

Monday, April 20 | 5:00PM - 7:00PM
Human BAT and Therapeutic Modulation II
Room: Ballroom 2-3
The types of human BAT and how their functions and amounts can be modulated.
Speaker 4 of 5
Francesc Villarroya, Universidad de Barcelona, Spain
BAT as Endocrine Organ: Identification of New Brown Adipokines

Monday, April 20 | 5:00PM - 7:00PM
Human BAT and Therapeutic Modulation II
Room: Ballroom 2-3
The types of human BAT and how their functions and amounts can be modulated.
Speaker 5 of 5
Denis P. Blondin, University of Sherbrooke, Canada
Short Talk: Postprandial Energy Metabolism of Brown Adipose Tissue in Cold-Acclimated Humans

Monday, April 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom 1
No registration fees are used to fund alcohol served at this function.

Monday, April 20 | 7:30PM - 10:00PM
Poster Session 3
Room: Ballroom 1


Tuesday, April 21 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, April 21 | 8:00AM - 11:00AM
Novel Pathways of Energy Expenditure
Room: Ballroom 2-3
New findings related to control of BAT amounts and function that work through the nervous system, immune cells and blood vessels.
Speaker 1 of 5
Sheila Collins, Vanderbilt University Medical Center, USA
Signaling Mechanisms Activating Brown Adipocytes and Thermogenesis by cAMP and cGMP from Mice to Humans

Tuesday, April 21 | 8:00AM - 11:00AM
Novel Pathways of Energy Expenditure
Room: Ballroom 2-3
New findings related to control of BAT amounts and function that work through the nervous system, immune cells and blood vessels.
Speaker 2 of 5
Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
Nuclear Receptors in Vagal Sensory Neurons Regulate Adipose Tissue and Energy Expenditure

Tuesday, April 21 | 8:00AM - 11:00AM
Novel Pathways of Energy Expenditure
Room: Ballroom 2-3
New findings related to control of BAT amounts and function that work through the nervous system, immune cells and blood vessels.
Speaker 3 of 5
* Antonio J. Vidal-Puig, University of Cambridge, UK
BMP 8b and Brown Fat Thermogenesis

Tuesday, April 21 | 8:00AM - 11:00AM
Novel Pathways of Energy Expenditure
Room: Ballroom 2-3
New findings related to control of BAT amounts and function that work through the nervous system, immune cells and blood vessels.
Speaker 4 of 5
Alexander Pfeifer, University of Bonn, Germany
CyclicGMP Signaling Enhances Brown Fat Function - Pharmacological Studies

Tuesday, April 21 | 8:00AM - 11:00AM
Novel Pathways of Energy Expenditure
Room: Ballroom 2-3
New findings related to control of BAT amounts and function that work through the nervous system, immune cells and blood vessels.
Speaker 5 of 5
Aaron P. Frank, Cedars-Sinai Medical Center, USA
Short Talk: Roux-en-Y Gastric Bypass Induces Browning of Gonadal Adipose Tissues

Tuesday, April 21 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby


Tuesday, April 21 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, April 21 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby


Tuesday, April 21 | 5:00PM - 7:00PM
Biochemistry and Bioenergetics of BAT
Room: Ballroom 3
Bioenergetic findings related to BAT function.
Speaker 1 of 4
Yuriy Kirichok, University of California, San Francisco, USA
Mitochondrial Uncoupling and Thermogenesis in Brown Fat

Tuesday, April 21 | 5:00PM - 7:00PM
Biochemistry and Bioenergetics of BAT
Room: Ballroom 3
Bioenergetic findings related to BAT function.
Speaker 2 of 4
Leslie P. Kozak, Polish Academy of Sciences, Poland
The Genetics of Brown Adipocyte Induction in White Fat Depots

Tuesday, April 21 | 5:00PM - 7:00PM
Biochemistry and Bioenergetics of BAT
Room: Ballroom 3
Bioenergetic findings related to BAT function.
Speaker 3 of 4
* Mary-Ellen Harper, University of Ottawa, Canada
Redox, ROS and the Control of UCP1

Tuesday, April 21 | 5:00PM - 7:00PM
Biochemistry and Bioenergetics of BAT
Room: Ballroom 3
Bioenergetic findings related to BAT function.
Speaker 4 of 4
Egor Akimov, Center of Sports Innovation Technologies and Teams Management, Russia
Short Talk: Participation of Brown Adipose Tissue in Lactate Utilization during Muscular Work

Tuesday, April 21 | 7:00PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Ballroom 3

Speaker 1 of 1
* Sven Enerbäck, University of Gothenburg, Sweden

Tuesday, April 21 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Ballroom 1-2
No registration fees are used to fund alcohol served at this function.

Tuesday, April 21 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 1-2
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Tuesday, April 21 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 1-2


Wednesday, April 22 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.