Web Desc
The Crossroads of Lipid Metabolism and Diabetes
Organizer(s): Russell A. DeBose-Boyd, Sudha Biddinger and Alan D. Attie
Date: April 19 - 24, 2015
Location: Tivoli Hotel and Congress Center, Copenhagen, Denmark
Lead Sponsor: Novo Nordisk A/S. Other Sponsors: MedImmune, Merck & Co., Inc. and Pfizer Inc.
Summary of Meeting:
The prevalence of obesity and Type 2 diabetes are reaching epidemic proportions throughout the world. One of the key features of these insulin-resistant disorders is disturbances in lipid metabolism. Overproduction of fatty acids in the liver leads to hypertriglyceridemia and low HDL cholesterol, which are important risk factors for the development of atherosclerosis, the most common cause of death among diabetic patients. In addition, excess fatty acid production and the accumulation of hepatic cholesterol promote the development of non-alcoholic steatohepatitis (NASH), which has become one of the leading indications for liver transplantation. In addition, disturbances in bile acid metabolism may also contribute to the development of atherosclerosis, as well as gallstones. The goal of this meeting is to provide attendees with the latest advances in the understanding of mechanisms governing the metabolism of lipids and how these pathways become dysregulated in the insulin resistant state. Elucidation of mechanisms underlying lipid metabolism may reveal new therapeutic strategies to combat atherosclerosis and other complications of diabetic patients. This program will stimulate interactions that are likely to augment and accelerate this process.
Scholarship Deadline: December 17 2014
Discounted Abstract Deadline: December 17 2014
Abstract Deadline: January 20 2015
Discounted Registration Deadline: February 18 2015
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
MedImmuneMerck & Co., Inc.Pfizer Inc.
We gratefully acknowledge additional support for this conference from:
Avanti Polar Lipids, Inc.Journal of Lipid Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Eli Lilly and Company

Isis Pharmaceuticals, Inc.

Regeneron Pharmaceuticals, Inc.
Keystone Symposia thanks our Lead Sponsor for generously supporting this meeting:
Novo Nordisk A/S
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL126455-01
Funding for this conference was made possible (in part) by 1R13HL126455-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Sunday, April 19 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Monday, April 20 | 7:30AM - 8:30AM
Breakfast
Room: Own Hotel


Monday, April 20 | 8:30AM - 8:45AM
Welcome Remarks
Room: Columbine/Harlekin

Speaker 1 of 2
* Alan D. Attie, University of Wisconsin-Madison, USA

Monday, April 20 | 8:30AM - 8:45AM
Welcome Remarks
Room: Columbine/Harlekin

Speaker 2 of 2
Anders Nykjaer, Aarhus University, Denmark
Living in a Butter Well

Monday, April 20 | 8:45AM - 9:45AM
Keynote Address
Room: Columbine/Harlekin

Speaker 1 of 1
Joseph L. Witztum, University of California, San Diego, USA
Lipoprotein Oxidation and Atherosclerosis


Monday, April 20 | 9:45AM - 12:00PM
LXR in Lipid Metabolism
Room: Columbine/Harlekin

Speaker 1 of 5
* Cynthia Hong, Pfizer, USA

Monday, April 20 | 9:45AM - 12:00PM
LXR in Lipid Metabolism
Room: Columbine/Harlekin

Speaker 2 of 5
Alan R. Tall, Columbia University, USA
TTC39B Modulates LXR, HDL Levels, Atherosclerosis and Steato-Hepatitis

Monday, April 20 | 9:45AM - 12:00PM
LXR in Lipid Metabolism
Room: Columbine/Harlekin

Speaker 3 of 5
Ira G. Schulman, University of Virginia Health System, USA
Control of Cholesterol Transport and HDL Function by Liver X Receptors

Monday, April 20 | 9:45AM - 12:00PM
LXR in Lipid Metabolism
Room: Columbine/Harlekin

Speaker 4 of 5
Christopher K. Glass, University of California, San Diego, USA
Regulation of the LXR/SREBP Axis in Macrophages

Monday, April 20 | 9:45AM - 12:00PM
LXR in Lipid Metabolism
Room: Columbine/Harlekin

Speaker 5 of 5
Noam Zelcer, Academic Medical Center, University of Amsterdam, Netherlands
Short Talk: USP2 Regulates the LDLR Pathway through Deubiquitylation of the E3-Ubiquitin Ligase IDOL

Monday, April 20 | 10:10AM - 10:30AM
Coffee Break
Room: Foyer


Monday, April 20 | 12:00PM - 1:00PM
Poster Setup
Room: Columbine/Harlekin


Monday, April 20 | 12:00PM - 5:00PM
On Own for Lunch


Monday, April 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Columbine/Harlekin


Monday, April 20 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, April 20 | 5:00PM - 7:15PM
Regulators and Arbiters of Lipoprotein Metabolism
Room: Columbine/Harlekin

Speaker 1 of 4
* Alan R. Tall, Columbia University, USA

Monday, April 20 | 5:00PM - 7:15PM
Regulators and Arbiters of Lipoprotein Metabolism
Room: Columbine/Harlekin

Speaker 2 of 4
Anders Nykjaer, Aarhus University, Denmark
Sortilin Receptors in Regulation of Cholesterol and Glucose Metabolism

Monday, April 20 | 5:00PM - 7:15PM
Regulators and Arbiters of Lipoprotein Metabolism
Room: Columbine/Harlekin

Speaker 3 of 4
Jeffrey Esko, University of California, San Diego, USA
Apoc-III In Triglyceride-Rich Lipoprotein Clearance

Monday, April 20 | 5:00PM - 7:15PM
Regulators and Arbiters of Lipoprotein Metabolism
Room: Columbine/Harlekin

Speaker 4 of 4
Nabil G. Seidah, Clinical Research Institute of Montreal, Canada
The Biology and Pathophysiology of PCSK9

Monday, April 20 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Monday, April 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Columbine/Harlekin


Tuesday, April 21 | 7:30AM - 8:30AM
Breakfast
Room: Own Hotel


Tuesday, April 21 | 8:30AM - 11:45AM
Insulin and Bile Acid Signaling
Room: Columbine/Harlekin

Speaker 1 of 7
* Morris J. Birnbaum, University of Pennsylvania and Pfizer, Inc., USA

Tuesday, April 21 | 8:30AM - 11:45AM
Insulin and Bile Acid Signaling
Room: Columbine/Harlekin

Speaker 2 of 7
Sudha B. Biddinger, Boston Children's Hospital, Harvard Medical School, USA
Flavin-Containing Monooxygenase 3 as a Novel Player in Diabetes-Associated Cardiovascular Disease

Tuesday, April 21 | 8:30AM - 11:45AM
Insulin and Bile Acid Signaling
Room: Columbine/Harlekin

Speaker 3 of 7
Domenico Accili, Columbia University, USA
Bile Acids and Insulin Signaling

Tuesday, April 21 | 8:30AM - 11:45AM
Insulin and Bile Acid Signaling
Room: Columbine/Harlekin

Speaker 4 of 7
Fredrik Bäckhed, University of Gothenburg, Sweden
Interaction between Bile Acids and Gut Microbiome in Relation to Host Metabolism

Tuesday, April 21 | 8:30AM - 11:45AM
Insulin and Bile Acid Signaling
Room: Columbine/Harlekin

Speaker 5 of 7
David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Dissecting the Tissue-Specific Actions of Endocrine FGF Signaling

Tuesday, April 21 | 8:30AM - 11:45AM
Insulin and Bile Acid Signaling
Room: Columbine/Harlekin

Speaker 6 of 7
Anna Worthmann, University Medical Center Hamburg-Eppendorf, Germany
Short Talk: Brown Adipose Tissue Activation Regulates Bile Acid Metabolism and Shapes the Gut Microbiome

Tuesday, April 21 | 8:30AM - 11:45AM
Insulin and Bile Acid Signaling
Room: Columbine/Harlekin

Speaker 7 of 7
Mete Civelek, University of Virginia, USA
Short Talk: Systems Genetics Analyses of Human Adipose Tissue Gene Expression Identify KLF14-Driven Trans Regulatory Transcript Network for Metabolic Disorders

Tuesday, April 21 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Tuesday, April 21 | 11:45AM - 1:00PM
Poster Setup
Room: Columbine/Harlekin


Tuesday, April 21 | 11:45AM - 5:00PM
On Own for Lunch


Tuesday, April 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Columbine/Harlekin


Tuesday, April 21 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, April 21 | 5:00PM - 7:00PM
Insulin Control of Lipid Metabolism
Room: Columbine/Harlekin

Speaker 1 of 4
* Fabienne Foufelle, Centre de Recherches des Cordeliers, France

Tuesday, April 21 | 5:00PM - 7:00PM
Insulin Control of Lipid Metabolism
Room: Columbine/Harlekin

Speaker 2 of 4
Morris J. Birnbaum, University of Pennsylvania and Pfizer, Inc., USA
The Regulation of Adipocyte Lipolysis by Insulin

Tuesday, April 21 | 5:00PM - 7:00PM
Insulin Control of Lipid Metabolism
Room: Columbine/Harlekin

Speaker 3 of 4
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Lessons about the Biology of Adipose Tissue and Insulin Resistance from Novel Models of Lipodystrophy

Tuesday, April 21 | 5:00PM - 7:00PM
Insulin Control of Lipid Metabolism
Room: Columbine/Harlekin

Speaker 4 of 4
Manju Kumari, Beth Israel Deaconess Medical Center, USA
Short Talk: Role of IRF3 in Glucose and Energy Metabolism

Tuesday, April 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Tuesday, April 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Columbine/Harlekin


Wednesday, April 22 | 7:30AM - 8:30AM
Breakfast
Room: Own Hotel


Wednesday, April 22 | 8:30AM - 11:30AM
Genes Affecting Lipid Metabolism and Diabetes Susceptibility
Room: Columbine/Harlekin

Speaker 1 of 7
* C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

Wednesday, April 22 | 8:30AM - 11:30AM
Genes Affecting Lipid Metabolism and Diabetes Susceptibility
Room: Columbine/Harlekin

Speaker 2 of 7
Alan D. Attie, University of Wisconsin-Madison, USA
The Role of Sorcs1 in Diabetes Susceptibility

Wednesday, April 22 | 8:30AM - 11:30AM
Genes Affecting Lipid Metabolism and Diabetes Susceptibility
Room: Columbine/Harlekin

Speaker 3 of 7
Markus Stoffel, ETH Zürich, Switzerland
Foxa2 and Regulation of Lipid Metabolism

Wednesday, April 22 | 8:30AM - 11:30AM
Genes Affecting Lipid Metabolism and Diabetes Susceptibility
Room: Columbine/Harlekin

Speaker 4 of 7
Timothy F. Osborne, Johns Hopkins, USA
Journal of Lipid Research Lectureship Introduced by JLR Editor-in-Chief, Joseph L. Witztum: SREBPs as Integrators of Lipid Metabolism and Cell Physiology

Wednesday, April 22 | 8:30AM - 11:30AM
Genes Affecting Lipid Metabolism and Diabetes Susceptibility
Room: Columbine/Harlekin

Speaker 5 of 7
Karen-Marie Pedersen, Aarhus University, Denmark
Short Talk: SorCS1, Encoded by the Alzheimer’s Disease and Type 2 Diabetes Susceptibility Gene SORCS1, Is a Potent Regulator of Peripheral Insulin Sensitivity

Wednesday, April 22 | 8:30AM - 11:30AM
Genes Affecting Lipid Metabolism and Diabetes Susceptibility
Room: Columbine/Harlekin

Speaker 6 of 7
Jeffrey A. Kohn, Emory University, USA
Short Talk: An Allosteric Network in LRH-1 Mediates Phospholipid-Driven Gene Regulation

Wednesday, April 22 | 8:30AM - 11:30AM
Genes Affecting Lipid Metabolism and Diabetes Susceptibility
Room: Columbine/Harlekin

Speaker 7 of 7
Lucia Krott, University Medical Center Hamburg Eppendorf, Germany
Short Talk: Adaptor Protein PID1 Is a Molecular Switch for LRP1 Function in Liver and Adipose Tissue

Wednesday, April 22 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Wednesday, April 22 | 11:30AM - 1:00PM
Poster Setup
Room: Columbine/Harlekin


Wednesday, April 22 | 11:30AM - 5:00PM
On Own for Lunch


Wednesday, April 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Columbine/Harlekin


Wednesday, April 22 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, April 22 | 5:00PM - 7:00PM
Nutrient Control of Lipid Metabolism
Room: Columbine/Harlekin

Speaker 1 of 5
* Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA

Wednesday, April 22 | 5:00PM - 7:00PM
Nutrient Control of Lipid Metabolism
Room: Columbine/Harlekin

Speaker 2 of 5
Matthew D. Hirschey, Duke University, USA
Mitochondrial Regulation of Lipid Metabolism


Wednesday, April 22 | 5:00PM - 7:00PM
Nutrient Control of Lipid Metabolism
Room: Columbine/Harlekin

Speaker 3 of 5
Marcia C. Haigis, Harvard Medical School, USA
Mitochondrial Dysfunction and Metabolic Disease

Wednesday, April 22 | 5:00PM - 7:00PM
Nutrient Control of Lipid Metabolism
Room: Columbine/Harlekin

Speaker 4 of 5
Catherine Postic, INSERM Institut Cochin, France
LXR Protects Mice Expressing a Constitutive Isoform of ChREBP from Non-Alcoholic Steatohepatitis (NASH)

Wednesday, April 22 | 5:00PM - 7:00PM
Nutrient Control of Lipid Metabolism
Room: Columbine/Harlekin

Speaker 5 of 5
Hervé Guillou, Institut National de la Recherche Agronomique, France
Short Talk: Liver PPARalpha Is Crucial for Whole Body Energy Homeostasis and Protects from NAFLDs

Wednesday, April 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Wednesday, April 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Columbine/Harlekin


Thursday, April 23 | 7:30AM - 8:30AM
Breakfast
Room: Own Hotel


Thursday, April 23 | 8:30AM - 11:30AM
Cellular Control of Lipid Synthesis
Room: Columbine/Harlekin

Speaker 1 of 7
* Timothy F. Osborne, Johns Hopkins, USA

Thursday, April 23 | 8:30AM - 11:30AM
Cellular Control of Lipid Synthesis
Room: Columbine/Harlekin

Speaker 2 of 7
Guosheng Liang, University of Texas Southwestern Medical Center, USA
Role of SREBP Pathway in Development of Hepatic Steatosis

Thursday, April 23 | 8:30AM - 11:30AM
Cellular Control of Lipid Synthesis
Room: Columbine/Harlekin

Speaker 3 of 7
Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA
Sterol and Nonsterol Signals Regulating ERAD of HMG CoA Reductase

Thursday, April 23 | 8:30AM - 11:30AM
Cellular Control of Lipid Synthesis
Room: Columbine/Harlekin

Speaker 4 of 7
Fabienne Foufelle, Centre de Recherches des Cordeliers, France
ER Stress Pathways in NAFLD

Thursday, April 23 | 8:30AM - 11:30AM
Cellular Control of Lipid Synthesis
Room: Columbine/Harlekin

Speaker 5 of 7
Jae Bum Kim, Seoul National University, South Korea
Short Talk: Off Switching Processes of Hepatic SREBP1c for Lipid Homeostasis upon Fasting

Thursday, April 23 | 8:30AM - 11:30AM
Cellular Control of Lipid Synthesis
Room: Columbine/Harlekin

Speaker 6 of 7
Shihyin Tsai, Buck Institute for Research on Aging, USA
Short Talk: Activated Muscle 4E-BP1 Signaling Improves Metabolic Parameters in Age- and Obesity-Induced Metabolic Deregulation

Thursday, April 23 | 8:30AM - 11:30AM
Cellular Control of Lipid Synthesis
Room: Columbine/Harlekin

Speaker 7 of 7
S.R. Murthy Madiraju, Montreal Diabetes Research Center, CR-CHUM, Canada
Short Talk: Deletion of ABHD6, a Monoacylglycerol Lipase, Induces Adipose Browning and Prevents Obesity and Type-2 Diabetes

Thursday, April 23 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Thursday, April 23 | 11:30AM - 5:00PM
On Own for Lunch


Thursday, April 23 | 4:30PM - 5:00PM
Coffee Available
Room: Carstensen Foyer


Thursday, April 23 | 5:00PM - 7:15PM
Therapeutic Targets for Molecular Disease
Room: Carstensen

Speaker 1 of 5
* Alan D. Attie, University of Wisconsin-Madison, USA

Thursday, April 23 | 5:00PM - 7:15PM
Therapeutic Targets for Molecular Disease
Room: Carstensen

Speaker 2 of 5
Rosanne M. Crooke, Ionis Pharmaceuticals, Inc., USA
Antisense Inhibition of Cardiovascular Risk Factors: From Bench to Clinic

Thursday, April 23 | 5:00PM - 7:15PM
Therapeutic Targets for Molecular Disease
Room: Carstensen

Speaker 3 of 5
Viktoria Gusarova, Regeneron Pharmaceuticals, USA
Alirocumab, Fully Human Antibody to PCSK9, Reduces LDL-C in Preclinical and Clinical Studies

Thursday, April 23 | 5:00PM - 7:15PM
Therapeutic Targets for Molecular Disease
Room: Carstensen

Speaker 4 of 5
Shirly Pinto, Kallyope, USA
Therapeutic Approaches for Lipid Modulation

Thursday, April 23 | 5:00PM - 7:15PM
Therapeutic Targets for Molecular Disease
Room: Carstensen

Speaker 5 of 5
Ruth E. Gimeno, Eli Lilly and Company, USA
FGF21 as a Therapeutic Target: New Insights

Thursday, April 23 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Thursday, April 23 | 8:00PM - 11:00PM
Entertainment
Room: Columbine/Harlekin
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources. Novo Nordisk A/S funding is not being used for this function.

Thursday, April 23 | 8:00PM - 11:00PM
Cash Bar
Room: Foyer


Friday, April 24 | 10:25AM - 10:25AM
Departure


*Session Chair.