Web Desc
Mechanisms of HIV Persistence: Implications for a Cure
Organizer(s): Olivier Lambotte, Steven G. Deeks and Guido Silvestri
Date: April 26 - May 01, 2015
Location: Boston Park Plaza, Boston, MA, USA
Sponsored by Bristol-Myers Squibb Company, Gilead Sciences, Inc., Merck & Co., Inc. and Sangamo BioSciences, Inc. Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation.
Summary of Meeting:
Despite long-term control of HIV replication with cART, HIV persists as silenced integrated DNA in memory CD4 T cells, and possibly in other cellular reservoirs, including naïve cells and macrophages. Low-level replenishment of the reservoir via limited cycles of replication may also contribute to persistence, at least in some patients. Curing HIV infection will only occur if these barriers are reversed, or if host capacity to control HIV indefinitely is improved. A number of promising interventions which might reverse latent infection have been identified, and proof that such drugs affect HIV transcription in vivo provided in pilot clinical trials. The observation that few patients treated during primary infection durably control replication-competent HIV after interrupting therapy suggests host responses might be manipulated, leading to a functional cure. The path forward will require a detailed understanding of the mechanisms of viral latency which could lead to the identification of new drugs, and a better knowledge of the plasticity and dynamics of the main HIV cell reservoirs: CD4 T cells and macrophages. The role of the tissue microenvironment has to be underlined with the major help of non-human primate models. At this meeting, experts from both within and outside the HIV field will present findings from recent advances on immune mechanisms and therapeutic strategies which could lead to an HIV cure.
Global Health Travel Award Deadline: November 25 2014
Scholarship Deadline: December 22 2014
Discounted Abstract Deadline: December 22 2014
Abstract Deadline: January 28 2015
Discounted Registration Deadline: February 26 2015
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates FoundationBristol-Myers Squibb CompanyGilead Sciences, Inc.Merck & Co., Inc.Sangamo BioSciences, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Gilead Sciences, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI116250-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 26 | 4:00PM - 8:00PM
Arrival and Registration
Room: Plaza Foyer


Sunday, April 26 | 6:00PM - 8:00PM
Welcome Mixer
Room: Statler Ballroom
No registration fees are used to fund alcohol served at this function.

Monday, April 27 | 7:30AM - 8:30AM
Breakfast
Room: Statler Room


Monday, April 27 | 8:00AM - 8:30AM
Poster Setup
Room: Plaza Ballroom


Monday, April 27 | 8:30AM - 9:30AM
Keynote Address
Room: Imperial Ballroom

Speaker 4 of 4
Françoise Barré-Sinoussi, Institut Pasteur, France
HIV Cure as an Aspirational Goal

Monday, April 27 | 8:30AM - 9:30AM
Keynote Address
Room: Imperial Ballroom

Speaker 3 of 4
* Steven G. Deeks, University of California, San Francisco, USA

Monday, April 27 | 8:30AM - 9:30AM
Keynote Address
Room: Imperial Ballroom

Speaker 2 of 4
* Guido Silvestri, Emory University School of Medicine, USA

Monday, April 27 | 8:30AM - 9:30AM
Keynote Address
Room: Imperial Ballroom

Speaker 1 of 4
* Olivier Lambotte, University Paris South, France

Monday, April 27 | 8:30AM - 5:00PM
Poster Viewing
Room: Plaza Ballroom


Monday, April 27 | 9:30AM - 11:45AM
Biology of HIV Latency
Room: Imperial Ballroom

Speaker 5 of 5
Valentina Vongrad, University Hospital Zürich, Switzerland
Short Talk: Longitudinal Patterns of HIV-1 Integration Sites (IS) in CD4+ T Cell Subsets in vivo

Monday, April 27 | 9:30AM - 11:45AM
Biology of HIV Latency
Room: Imperial Ballroom

Speaker 4 of 5
Kai Deng, Sun Yat-sen University, China
Short Talk: The Establishment of HIV-1 Latency Is Restricted within a Small Subset of Primary CD4+ T Cells and Can Be Prevented by Viral-Specific CTLs

Monday, April 27 | 9:30AM - 11:45AM
Biology of HIV Latency
Room: Imperial Ballroom

Speaker 3 of 5
Lillian B. Cohn, Chan Zuckerberg Biohub, USA
Short Talk: HIV-1 Integration Landscape in Active and Latent Infection

Monday, April 27 | 9:30AM - 11:45AM
Biology of HIV Latency
Room: Imperial Ballroom

Speaker 2 of 5
* Carine M. Van Lint, University of Brussels, Belgium
Molecular Mechanisms of HIV-1 Postintegration Latency: Implications for Therapeutic Strategies

Monday, April 27 | 9:30AM - 11:45AM
Biology of HIV Latency
Room: Imperial Ballroom

Speaker 1 of 5
Monsef Benkirane, Institut de Genetique Humaine, France
Toward Development of an Animal Model Dedicated to Explore HIV-1 Persistence

Monday, April 27 | 10:10AM - 10:40AM
Coffee Break
Room: Statler Room


Monday, April 27 | 11:45AM - 12:45PM
Lunch
Room: Plaza Ballroom


Monday, April 27 | 12:15PM - 2:30PM
Poster Session 1
Room: Plaza Ballroom


Monday, April 27 | 2:30PM - 4:30PM
Workshop 1: HIV Reservoirs, Clinical Care and Clinical Resul
ts
Room: Imperial Ballroom

Speaker 5 of 5
Miles P. Davenport, University of New South Wales, Australia
Low Frequency of HIV Rebound after Antiretroviral Treatment Interruption

Monday, April 27 | 2:30PM - 4:30PM
Workshop 1: HIV Reservoirs, Clinical Care and Clinical Resul
ts
Room: Imperial Ballroom

Speaker 4 of 5
Alexander O. Pasternak, University of Amsterdam, Netherlands
Long-Term Effect of Temporary ART during Primary HIV Infection on the Viral Reservoir

Monday, April 27 | 2:30PM - 4:30PM
Workshop 1: HIV Reservoirs, Clinical Care and Clinical Resul
ts
Room: Imperial Ballroom

Speaker 3 of 5
Rémi Fromentin, Canada
Distribution of Cellular HIV Reservoirs after more than 15 Years of ART

Monday, April 27 | 2:30PM - 4:30PM
Workshop 1: HIV Reservoirs, Clinical Care and Clinical Resul
ts
Room: Imperial Ballroom

Speaker 2 of 5
Katherine M. Bruner, Johns Hopkins University School of Medicine, USA
Analysis of HIV-1 Genomes in the Latent Reservoir Indicates Rapid Accumulation of Defective Proviruses

Monday, April 27 | 2:30PM - 4:30PM
Workshop 1: HIV Reservoirs, Clinical Care and Clinical Resul
ts
Room: Imperial Ballroom

Speaker 1 of 5
* Christine Rouzioux, Necker Hospital and University of Paris Descartes, France
HIV Reservoirs Measurement in Clinical Care: Where Are We Going?

Monday, April 27 | 4:30PM - 5:00PM
Coffee Available
Room: Statler Room


Monday, April 27 | 5:00PM - 7:15PM
Detection and Quantification of HIV Reservoirs
Room: Imperial Ballroom

Speaker 1 of 4
Ronald N. Germain, NIAID, National Institutes of Health, USA
Imaging Immunity: Creating a Spatiotemporal Understanding of Host Defense

Monday, April 27 | 5:00PM - 7:15PM
Detection and Quantification of HIV Reservoirs
Room: Imperial Ballroom

Speaker 2 of 4
* Robert F. Siliciano, Johns Hopkins University School of Medicine, USA
HIV Reservoirs: What We Know and What We Don't Know

Monday, April 27 | 5:00PM - 7:15PM
Detection and Quantification of HIV Reservoirs
Room: Imperial Ballroom

Speaker 3 of 4
Una O'Doherty, University of Pennsylvania Medical Center, USA
HIV Reservoir Expression

Monday, April 27 | 5:00PM - 7:15PM
Detection and Quantification of HIV Reservoirs
Room: Imperial Ballroom

Speaker 4 of 4
Douglas D. Richman, University of California, San Diego, USA
Measuring the Latent Reservoir

Monday, April 27 | 7:15PM - 7:15PM
On Own for Dinner


Tuesday, April 28 | 7:30AM - 8:30AM
Breakfast
Room: Statler Room


Tuesday, April 28 | 8:30AM - 11:45AM
CD4 T Cells as Reservoir
Room: Imperial Ballroom

Speaker 1 of 6
Chen Dong, Tsinghua University, China
T Cell Subsets in Immunity

Tuesday, April 28 | 8:30AM - 11:45AM
CD4 T Cells as Reservoir
Room: Imperial Ballroom

Speaker 2 of 6
* Sharon R. Lewin, University of Melbourne, Australia
Chemokines and the HIV Reservoir in CD4 T Cells

Tuesday, April 28 | 8:30AM - 11:45AM
CD4 T Cells as Reservoir
Room: Imperial Ballroom

Speaker 3 of 6
Richard A. Koup, NIAID, National Institutes of Health, USA
Tfh Cells Are a Site of Active HIV Replication

Tuesday, April 28 | 8:30AM - 11:45AM
CD4 T Cells as Reservoir
Room: Imperial Ballroom

Speaker 4 of 6
Matthieu Perreau, University Hospital of Lausanne, Switzerland
Short Talk: Lymph node PD-1+/Tfh Memory CD4 T Cells Are the Major Source of HIV-1 Replication Competent and Infectious Virus in Long-Term Treated Aviremic HIV-Infected Subjects

Tuesday, April 28 | 8:30AM - 11:45AM
CD4 T Cells as Reservoir
Room: Imperial Ballroom

Speaker 5 of 6
Joseph K. Wong, University of California, San Francisco, USA
Charateristics of Tissue HIV Reservoirs in vivo

Tuesday, April 28 | 8:30AM - 11:45AM
CD4 T Cells as Reservoir
Room: Imperial Ballroom

Speaker 6 of 6
Eli Andrew Boritz, NIAID, National Institutes of Health, USA
Short Talk: Mechanisms of HIV Persistence in HIV Controllers

Tuesday, April 28 | 9:50AM - 10:10AM
Coffee Break
Room: Statler Room


Tuesday, April 28 | 11:45AM - 1:00PM
Poster Setup
Room: Plaza Ballroom


Tuesday, April 28 | 11:45AM - 5:00PM
On Own for Lunch


Tuesday, April 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Plaza Ballroom


Tuesday, April 28 | 2:30PM - 4:30PM
Workshop 2: Modulations of the Immune System to Reduce the S
ize of HIV Reservoirs
Room: Imperial Ballroom

Speaker 1 of 9
* Asier Sáez-Cirión, Institut Pasteur, France

Tuesday, April 28 | 2:30PM - 4:30PM
Workshop 2: Modulations of the Immune System to Reduce the S
ize of HIV Reservoirs
Room: Imperial Ballroom

Speaker 2 of 9
Zelda Euler, Ragon Institute of MGH, MIT and Harvard, USA
Eradication of HIV Reservoirs with Antibody-Mediated Killing

Tuesday, April 28 | 2:30PM - 4:30PM
Workshop 2: Modulations of the Immune System to Reduce the S
ize of HIV Reservoirs
Room: Imperial Ballroom

Speaker 3 of 9
Edward A. Berger, NIAID, National Institutes of Health, USA
Targeted Cell Killing to Achieve a (Functional) Cure: Different Strategies for Acute Versus Chronic Infection

Tuesday, April 28 | 2:30PM - 4:30PM
Workshop 2: Modulations of the Immune System to Reduce the S
ize of HIV Reservoirs
Room: Imperial Ballroom

Speaker 4 of 9
Selena Viganò, Ragon Institute, USA
Immune Correlates of HIV-1 DNA Decrease during Treatment with Pegylated IFN-alpha in HIV/HCV Co-Infected Patients

Tuesday, April 28 | 2:30PM - 4:30PM
Workshop 2: Modulations of the Immune System to Reduce the S
ize of HIV Reservoirs
Room: Imperial Ballroom

Speaker 5 of 9
Emily R. Roberts, Takeda Pharmaceuticals International, USA
Rapid Evolution of SIV-Specific CD8 T Cell Cytolytic Potential during Acute SIV Infection

Tuesday, April 28 | 2:30PM - 4:30PM
Workshop 2: Modulations of the Immune System to Reduce the S
ize of HIV Reservoirs
Room: Imperial Ballroom

Speaker 6 of 9
Kellie N. Smith, Johns Hopkins University School of Medicine, USA
Effective Targeting of the HIV Reservoir Requires a Broad de novo Induction of Primary Rather than Memory CTL

Tuesday, April 28 | 2:30PM - 4:30PM
Workshop 2: Modulations of the Immune System to Reduce the S
ize of HIV Reservoirs
Room: Imperial Ballroom

Speaker 7 of 9
Guido Silvestri, Emory University School of Medicine, USA
Anti-Apoptosis Agent Preserves CD4 T Cells and Prevents Disease Progression in SIV-Infected Rhesus macaques

Tuesday, April 28 | 2:30PM - 4:30PM
Workshop 2: Modulations of the Immune System to Reduce the S
ize of HIV Reservoirs
Room: Imperial Ballroom

Speaker 8 of 9
George B. Kyei, University of Ghana, Ghana
Largazoles Are a Novel Group of Lysine Deacetylase Inhibitors that Potently Reactivate HIV from Latency

Tuesday, April 28 | 2:30PM - 4:30PM
Workshop 2: Modulations of the Immune System to Reduce the S
ize of HIV Reservoirs
Room: Imperial Ballroom

Speaker 9 of 9
Petronela Ancuta, Centre de Recherche de l'Universite de Montreal, Canada
Persistence of Replication Competent HIV-1 Reservoirs under ART in Central Memory Th17 Cells

Tuesday, April 28 | 4:30PM - 5:00PM
Coffee Available
Room: Statler Room


Tuesday, April 28 | 5:00PM - 7:00PM
Non-CD4 T Cell Reservoirs
Room: Imperial Ballroom

Speaker 1 of 4
Jason M. Brenchley, NIAID, National Institutes of Health, USA
Phagocytosis of SIV-Infected T Cells Can Explain Viral DNA within Myeloid Cells in vivo

Tuesday, April 28 | 5:00PM - 7:00PM
Non-CD4 T Cell Reservoirs
Room: Imperial Ballroom

Speaker 2 of 4
* Olivier Lambotte, University Paris South, France
Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection

Tuesday, April 28 | 5:00PM - 7:00PM
Non-CD4 T Cell Reservoirs
Room: Imperial Ballroom

Speaker 3 of 4
Melissa J. Churchill, RMIT University, Australia
Microglia and the CNS as a Sanctuary for HIV

Tuesday, April 28 | 5:00PM - 7:00PM
Non-CD4 T Cell Reservoirs
Room: Imperial Ballroom

Speaker 4 of 4
Serge Benichou, Cochin Institute, France
Short Talk: Productive HIV-1 Infection of Macrophages by Viral Cell-to-Cell Transfer from Infected CD4+ T Lymphocytes

Tuesday, April 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Plaza Ballroom
No registration fees are used to fund alcohol served at this function.

Tuesday, April 28 | 7:30PM - 10:00PM
Poster Session 2
Room: Plaza Ballroom


Wednesday, April 29 | 7:30AM - 8:30AM
Breakfast
Room: Statler Room


Wednesday, April 29 | 8:30AM - 11:45AM
Functional Eradication of HIV Reservoirs: Current Approaches
and New Directions

Room: Imperial Ballroom

Speaker 1 of 6
* Steven G. Deeks, University of California, San Francisco, USA
Short-Term Disulfiram to Reverse Latent HIV Infection

Wednesday, April 29 | 8:30AM - 11:45AM
Functional Eradication of HIV Reservoirs: Current Approaches
and New Directions

Room: Imperial Ballroom

Speaker 2 of 6
Thomas A. Rasmussen, Aarhus University Hospital, Denmark
Reversal of HIV-1 Latency by HDAC Inhibitors: Part of a Curative Strategy?

Wednesday, April 29 | 8:30AM - 11:45AM
Functional Eradication of HIV Reservoirs: Current Approaches
and New Directions

Room: Imperial Ballroom

Speaker 3 of 6
Paula M. Cannon, University of Southern California, Keck School of Medicine, USA
Targeted Nuclease Approaches for a Functional Cure

Wednesday, April 29 | 8:30AM - 11:45AM
Functional Eradication of HIV Reservoirs: Current Approaches
and New Directions

Room: Imperial Ballroom

Speaker 4 of 6
Romas Geleziunas, Gilead Sciences, Inc., USA
Concepts of Combination Therapy to Achieve ART-Free HIV Remission

Wednesday, April 29 | 8:30AM - 11:45AM
Functional Eradication of HIV Reservoirs: Current Approaches
and New Directions

Room: Imperial Ballroom

Speaker 5 of 6
Brad Jones, Weill Cornell Medicine, USA
Short Talk: Cytotoxic T-Lymphocytes in Combination with the IL-15 Superagonist ALT-803 Eliminate Latently HIV-Infected Autologous CD4+ T-Cells from Natural Reservoirs

Wednesday, April 29 | 8:30AM - 11:45AM
Functional Eradication of HIV Reservoirs: Current Approaches
and New Directions

Room: Imperial Ballroom

Speaker 6 of 6
Joumana Zeidan, Case Western Reserve University, USA
Short Talk: Decay of the HIV Reservoir Post Autologous Transfer of ZFN CCR5 Modified CD4 T Cells (SB-728-T) Correlates with Generation of a T Memory Stem Cell-Like Population and Enhanced HIV-Specific CD8 T Cell Polyfunctionality

Wednesday, April 29 | 9:50AM - 10:10AM
Coffee Break
Room: Statler Room


Wednesday, April 29 | 11:45AM - 1:00PM
Poster Setup
Room: Plaza Ballroom


Wednesday, April 29 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, April 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Plaza Ballroom


Wednesday, April 29 | 1:30PM - 4:30PM
NeuroHIV Workshop Program:HIV Persistence in the CNS: Contro
versies and Challenges
Room: Imperial Ballroom
Organizers: Serena Spudich, Victor Valcour, Jeymohan Joseph and Jintanat Ananworanich

Wednesday, April 29 | 1:30PM - 2:40PM
NeuroHIV Workshop Program: Investigating HIV Persistence in
the CNS
Room: Imperial Ballroom
Organized by the National Institute of Mental Health (NIMH)
Coordinated by the International NeuroHIV Cure Consortium (INHCC) (www.inhcc.net)
Speaker 1 of 7
* Victor Valcour, University of California, San Francisco, USA

Wednesday, April 29 | 1:30PM - 2:40PM
NeuroHIV Workshop Program: Investigating HIV Persistence in
the CNS
Room: Imperial Ballroom
Organized by the National Institute of Mental Health (NIMH)
Coordinated by the International NeuroHIV Cure Consortium (INHCC) (www.inhcc.net)
Speaker 2 of 7
Jeymohan Joseph, National Institute of Mental Health, USA
Opening Remarks

Wednesday, April 29 | 1:30PM - 2:40PM
NeuroHIV Workshop Program: Investigating HIV Persistence in
the CNS
Room: Imperial Ballroom
Organized by the National Institute of Mental Health (NIMH)
Coordinated by the International NeuroHIV Cure Consortium (INHCC) (www.inhcc.net)
Speaker 3 of 7
Janice E. Clements, Johns Hopkins University, USA
HIV CURE: Reactivation of SIV in Plasma, CSF and CNS in the SIV Macaque Model

Wednesday, April 29 | 1:30PM - 2:40PM
NeuroHIV Workshop Program: Investigating HIV Persistence in
the CNS
Room: Imperial Ballroom
Organized by the National Institute of Mental Health (NIMH)
Coordinated by the International NeuroHIV Cure Consortium (INHCC) (www.inhcc.net)
Speaker 4 of 7
Sandhya Vasan, US Military HIV Research Program, USA
CNS Findings in a Non-Accelerated SHIV Macaque Model

Wednesday, April 29 | 1:30PM - 2:40PM
NeuroHIV Workshop Program: Investigating HIV Persistence in
the CNS
Room: Imperial Ballroom
Organized by the National Institute of Mental Health (NIMH)
Coordinated by the International NeuroHIV Cure Consortium (INHCC) (www.inhcc.net)
Speaker 5 of 7
Sarah E. Palmer, University of Sydney, Australia
Low Level CSF HIV Persistence during Systemic Antiretroviral Suppression

Wednesday, April 29 | 1:30PM - 2:40PM
NeuroHIV Workshop Program: Investigating HIV Persistence in
the CNS
Room: Imperial Ballroom
Organized by the National Institute of Mental Health (NIMH)
Coordinated by the International NeuroHIV Cure Consortium (INHCC) (www.inhcc.net)
Speaker 6 of 7
Richard W. Price, University of California, San Francisco, USA
Persistent CNS Immune Activation in Treated HIV

Wednesday, April 29 | 1:30PM - 2:40PM
NeuroHIV Workshop Program: Investigating HIV Persistence in
the CNS
Room: Imperial Ballroom
Organized by the National Institute of Mental Health (NIMH)
Coordinated by the International NeuroHIV Cure Consortium (INHCC) (www.inhcc.net)
Speaker 7 of 7
Serena Spudich, Yale University, USA
Early Detection of HIV in the CNS and Impact of Early Treatment

Wednesday, April 29 | 2:50PM - 4:20PM
NeuroHIV Workshop Program: State of the Science Discussion P
anels A and B
Room: Imperial Ballroom
Organized by National Institute of Mental Health (NIMH)
Coordinated by the International NeuroHIV Cure Consortium (INHCC) (www.inhcc.net)

Wednesday, April 29 | 2:50PM - 3:40PM
Panel A: Are Myeloid Cells Infected by HIV?
Room: Imperial Ballroom

Speaker 1 of 6
* Steven G. Deeks, University of California, San Francisco, USA

Wednesday, April 29 | 2:50PM - 3:40PM
Panel A: Are Myeloid Cells Infected by HIV?
Room: Imperial Ballroom

Speaker 2 of 6
Lishomwa C. Ndhlovu, University of Hawaii, USA

Wednesday, April 29 | 2:50PM - 3:40PM
Panel A: Are Myeloid Cells Infected by HIV?
Room: Imperial Ballroom

Speaker 3 of 6
Jason M. Brenchley, NIAID, National Institutes of Health, USA

Wednesday, April 29 | 2:50PM - 3:40PM
Panel A: Are Myeloid Cells Infected by HIV?
Room: Imperial Ballroom

Speaker 4 of 6
Mario Stevenson, University of Miami, Leonard M. Miller School of Medicine, USA

Wednesday, April 29 | 2:50PM - 3:40PM
Panel A: Are Myeloid Cells Infected by HIV?
Room: Imperial Ballroom

Speaker 5 of 6
J. Victor Garcia-Martinez, University of North Carolina at Chapel Hill, USA

Wednesday, April 29 | 2:50PM - 3:40PM
Panel A: Are Myeloid Cells Infected by HIV?
Room: Imperial Ballroom

Speaker 6 of 6
Karl Salzwedel, NIAID, National Institutes of Health, USA

Wednesday, April 29 | 3:40PM - 4:20PM
Panel B: Is the CNS a Potential Reservoir for HIV?
Room: Imperial Ballroom

Speaker 1 of 5
* Jintanat Ananworanich, US Military HIV Research Program, USA

Wednesday, April 29 | 3:40PM - 4:20PM
Panel B: Is the CNS a Potential Reservoir for HIV?
Room: Imperial Ballroom

Speaker 2 of 5
Melissa J. Churchill, RMIT University, Australia

Wednesday, April 29 | 3:40PM - 4:20PM
Panel B: Is the CNS a Potential Reservoir for HIV?
Room: Imperial Ballroom

Speaker 3 of 5
Douglas D. Richman, University of California, San Diego, USA

Wednesday, April 29 | 3:40PM - 4:20PM
Panel B: Is the CNS a Potential Reservoir for HIV?
Room: Imperial Ballroom

Speaker 4 of 5
Ronald I. Swanstrom, University of North Carolina at Chapel Hill, USA

Wednesday, April 29 | 3:40PM - 4:20PM
Panel B: Is the CNS a Potential Reservoir for HIV?
Room: Imperial Ballroom

Speaker 5 of 5
David M. Margolis, University of North Carolina at Chapel Hill, USA

Wednesday, April 29 | 4:30PM - 5:00PM
Coffee Available
Room: Statler Room


Wednesday, April 29 | 5:00PM - 7:00PM
How to Fight Immune Exhaustion?
Room: Imperial Ballroom

Speaker 1 of 4
Daniel E. Kaufmann, University of Montreal, Canada
Co-Inhibitory Pathways and HIV Persistence

Wednesday, April 29 | 5:00PM - 7:00PM
How to Fight Immune Exhaustion?
Room: Imperial Ballroom

Speaker 2 of 4
Stephen Mason, Bristol-Myers Squibb, USA
Approaches to HIV Remission

Wednesday, April 29 | 5:00PM - 7:00PM
How to Fight Immune Exhaustion?
Room: Imperial Ballroom

Speaker 3 of 4
* Rafick Sekaly, Emory University, USA
Promoting CD4 Differentiation

Wednesday, April 29 | 5:00PM - 7:00PM
How to Fight Immune Exhaustion?
Room: Imperial Ballroom

Speaker 4 of 4
Colleen S. McGary, Emory University, USA
Short Talk: CTLA-4-Expressing CD4 T Cells Are Critical Contributors to SIV Viral Persistence

Wednesday, April 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Plaza Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, April 29 | 7:30PM - 10:00PM
Poster Session 3
Room: Plaza Ballroom


Thursday, April 30 | 7:30AM - 8:30AM
Breakfast
Room: Statler Room


Thursday, April 30 | 8:30AM - 12:00PM
Strengths and Weaknesses of NHP Models
Room: Imperial Ballroom

Speaker 1 of 7
* Guido Silvestri, Emory University School of Medicine, USA
Optimizing the NHP Model for Cure Studies

Thursday, April 30 | 8:30AM - 12:00PM
Strengths and Weaknesses of NHP Models
Room: Imperial Ballroom

Speaker 2 of 7
Caroline P.B. Passaes, Institut Pasteur, France
Animal Models of Spontaneous Control: Lessons Learned and Future Directions

Thursday, April 30 | 8:30AM - 12:00PM
Strengths and Weaknesses of NHP Models
Room: Imperial Ballroom

Speaker 3 of 7
Gregory Q. Del Prete, Frederick National Laboratory for Cancer Research, USA
Development and Utilization of Non-Human Primate Models of Combination Antiretroviral Therapy for Studies of HIV Functional Cure/Eradication

Thursday, April 30 | 8:30AM - 12:00PM
Strengths and Weaknesses of NHP Models
Room: Imperial Ballroom

Speaker 4 of 7
Afam Okoye, Oregon Health & Science University, USA
Early Antiretroviral Therapy Limits Viral Reservoir in SIV-Infected Macaques

Thursday, April 30 | 8:30AM - 12:00PM
Strengths and Weaknesses of NHP Models
Room: Imperial Ballroom

Speaker 5 of 7
Pamela J. Skinner, University of Minnesota, USA
Short Talk: Location, Abundance and Phenotype of Follicular SIV-Specific CTL during Chronic Infection

Thursday, April 30 | 8:30AM - 12:00PM
Strengths and Weaknesses of NHP Models
Room: Imperial Ballroom

Speaker 6 of 7
Emily Ryan, Emory University, USA
Short Talk: Loss of Function of Intestinal Th17 and Th22 Cells Contributes to Persistent Immune Activation in SIV-Infected Rhesus macaques

Thursday, April 30 | 8:30AM - 12:00PM
Strengths and Weaknesses of NHP Models
Room: Imperial Ballroom

Speaker 7 of 7
Khader Ghneim, Case Western Reserve University, USA
Short Talk: FOXO3 and the Interferon Pathway Regulate Immune Reconstitution and the Size of the HIV Reservoir

Thursday, April 30 | 9:50AM - 10:10AM
Coffee Break
Room: Statler Room


Thursday, April 30 | 12:00PM - 5:00PM
On Own for Lunch


Thursday, April 30 | 2:30PM - 4:30PM
Workshop 4: Strategies to Reduce HIV Reservoirs: The Point o
f View of the Patient
Room: Imperial Ballroom

Speaker 1 of 6
* Olivier Lambotte, University Paris South, France
Perspectives on the Acceptability of HIV Cure Trials: The Challenges for Physicians and PLWHIV (ANRS APSEC)

Thursday, April 30 | 2:30PM - 4:30PM
Workshop 4: Strategies to Reduce HIV Reservoirs: The Point o
f View of the Patient
Room: Imperial Ballroom

Speaker 2 of 6
Sara Morón-López, AIDS Research Institute - IrsiCaixa, Spain
Impact of IFNalpha-2a on the Replication-Competent HIV-1 Reservoir in CD4+ T Cells

Thursday, April 30 | 2:30PM - 4:30PM
Workshop 4: Strategies to Reduce HIV Reservoirs: The Point o
f View of the Patient
Room: Imperial Ballroom

Speaker 3 of 6
Genevieve Clutton, University of North Carolina, USA
Differential Effects of HIV Latency Reversing Agents on T Cell Phenotype and Function: Implications for HIV Cure

Thursday, April 30 | 2:30PM - 4:30PM
Workshop 4: Strategies to Reduce HIV Reservoirs: The Point o
f View of the Patient
Room: Imperial Ballroom

Speaker 4 of 6
Miguel de Mulder Rougvie, Weill Cornell Medicine, USA
Modulation of HERV Family Expression after Treatment with HDAC Inhibitors

Thursday, April 30 | 2:30PM - 4:30PM
Workshop 4: Strategies to Reduce HIV Reservoirs: The Point o
f View of the Patient
Room: Imperial Ballroom

Speaker 5 of 6
Sulggi Angela Lee, University of California, San Francisco, USA
Anti-HIV Antibody Responses Reflect the Quantifiable HIV Reservoir Size

Thursday, April 30 | 2:30PM - 4:30PM
Workshop 4: Strategies to Reduce HIV Reservoirs: The Point o
f View of the Patient
Room: Imperial Ballroom

Speaker 6 of 6
Johanna Tauriainen, Karolinska Institutet, Sweden
Sustained Expression of the Inhibitory Receptor TIGIT Is Linked to CD8 T Cell Exhaustion Despite Successful ART

Thursday, April 30 | 4:30PM - 5:00PM
Coffee Available
Room: Statler Room


Thursday, April 30 | 5:00PM - 6:45PM
Limitations of Antiretroviral Therapy and New Perspectives
Room: Imperial Ballroom

Speaker 1 of 3
* Courtney Fletcher, University of Nebraska Medical Center, USA
Is There a Pharmacologic Basis for Persistent HIV Replication?

Thursday, April 30 | 5:00PM - 6:45PM
Limitations of Antiretroviral Therapy and New Perspectives
Room: Imperial Ballroom

Speaker 2 of 3
Asier Sáez-Cirión, Institut Pasteur, France
Treat Early Is the Clue? Example of the Post-Treatment Controllers

Thursday, April 30 | 5:00PM - 6:45PM
Limitations of Antiretroviral Therapy and New Perspectives
Room: Imperial Ballroom

Speaker 3 of 3
Jintanat Ananworanich, US Military HIV Research Program, USA
Effects of Treatment during Acute HIV Infection on HIV Persistence

Thursday, April 30 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Imperial Ballroom


Thursday, April 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Plaza Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, April 30 | 8:00PM - 11:00PM
Entertainment
Room: Plaza Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, April 30 | 8:00PM - 11:00PM
Cash Bar
Room: Plaza Ballroom


Friday, May 01 | 10:25AM - 10:25AM
Departure


*Session Chair.