Web Desc
The Hippo Pathway: Signaling, Development and Disease
Organizer(s): Fernando D. Camargo, Kun-Liang Guan and Helen McNeill
Date: May 17 - 21, 2015
Location: Sagebrush Inn & Suites, Taos, NM, USA
Sponsored by Bayer HealthCare Pharmaceuticals and OncoMed Pharmaceuticals, Inc.
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Summary of Meeting:
SIGNIFICANCE - The study of developmental signaling pathways has transformed our understanding of disease. The Hippo signaling pathway is a relatively novel signaling network that controls organ size, stem cell activity, and tumorigenesis. Therefore, the Hippo cascade and its components are attractive targets for the development of regenerative medicine and cancer drugs. The emerging paradigm in the field indicates that the Hippo pathway is a central sensor of multiple biological inputs, including cell adhesion, polarity, mechanical forces, and secreted ligands. These findings highlight the unique interdisciplinary nature of the field as the work from Drosophila geneticists, mammalian signalers, bioengineers, and developmental and cancer biologists needs to be integrated. These emerging paradoxes, the cancer and stem cell relevance of the pathway, and need for a larger forum to bring experts from multiple fields together prompted us to propose this meeting. The specific goals of this conference are to: 1) Identify and integrate evolutionary conserved inputs that control this cascade; 2) Define the transcriptional targets of the pathway that drive growth; 3) Understand the roles of Hippo in the physiology of multiple tissues; and 4) Define targets for chemical inhibitors and activators within pathway components. INNOVATION - This meeting follows on the 2013 Hippo Keystone meeting, which has been received with tremendous interest. This is the only conference specific to the Hippo field. The meeting will bring together Drosophila geneticists, basic and clinical cancer researchers, and the developmental and stem cell research community. It should consolidate the emerging field and have an impact on development of new cancer therapies.
Scholarship Deadline: January 20 2015
Discounted Abstract Deadline: January 20 2015
Abstract Deadline: February 19 2015
Discounted Registration Deadline: March 17 2015
Abstacts when book is in proofing process


Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer HealthCare PharmaceuticalsOncoMed Pharmaceuticals, Inc.
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Inventiva
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Inventiva
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA196195-01
Funding for this conference was made possible (in part) by 1R13CA196195-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, May 17 | 4:00PM - 8:00PM
Arrival and Registration
Room: Sagebrush Lobby & Cantina


Sunday, May 17 | 6:00PM - 8:00PM
Welcome Mixer
Room: Sagebrush Lobby & Cantina
No registration fees are used to fund alcohol served at this function.

Monday, May 18 | 7:30AM - 8:30AM
Breakfast
Room: Sagebrush Lobby & Cantina


Monday, May 18 | 8:30AM - 9:30AM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 1
Duojia D.J. Pan, HHMI/Johns Hopkins University School of Medicine, USA
Control of Organ Size and Tumor Suppression by the Hippo Signaling Pathway

Monday, May 18 | 9:30AM - 12:45PM
Membrane and Upstream Inputs
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Fernando D. Camargo, Boston Children's Hospital, USA

Monday, May 18 | 9:30AM - 12:45PM
Membrane and Upstream Inputs
Room: Chamisa Ballroom 1

Speaker 2 of 7
Jin Jiang, University of Texas Southwestern Medical Center, USA
Genetic Dissection of Hpo Signaling Pathway in Organ Size Control and Stem Cell Regulation

Monday, May 18 | 9:30AM - 12:45PM
Membrane and Upstream Inputs
Room: Chamisa Ballroom 1

Speaker 3 of 7
Kun-Liang Guan, University of California, San Diego, USA
Regulation of Hippo-YAP Pathway by Energy Stress and Cancer Mutations

Monday, May 18 | 9:30AM - 12:45PM
Membrane and Upstream Inputs
Room: Chamisa Ballroom 1

Speaker 4 of 7
Kenneth Irvine, Rutgers University, USA
Mechanical Control of Hippo Signaling in vivo

Monday, May 18 | 9:30AM - 12:45PM
Membrane and Upstream Inputs
Room: Chamisa Ballroom 1

Speaker 5 of 7
Iswar K. Hariharan, University of California, Berkeley, USA
The Hippo Pathway: Inputs and Outputs

Monday, May 18 | 9:30AM - 12:45PM
Membrane and Upstream Inputs
Room: Chamisa Ballroom 1

Speaker 6 of 7
Liliana Attisano, University of Toronto, Canada
Short Talk: Multidimensional High-throughput Screening Identifies Hippo Pathway Regulators

Monday, May 18 | 9:30AM - 12:45PM
Membrane and Upstream Inputs
Room: Chamisa Ballroom 1

Speaker 7 of 7
Jimmy Hu, University of California, San Francisco, USA
Short Talk: The Role of Hippo Signaling and YAP/TAZ in the Incisor Stem Cell Niche

Monday, May 18 | 10:10AM - 10:30AM
Coffee Break
Room: Chamisa Lobby


Monday, May 18 | 12:45PM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Monday, May 18 | 12:45PM - 5:00PM
On Own for Lunch


Monday, May 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Monday, May 18 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Monday, May 18 | 5:00PM - 7:00PM
Hippo in Flies and Mammals: Signaling and Integration
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Georg A. Halder, Katholieke Universiteit Leuven, Belgium

Monday, May 18 | 5:00PM - 7:00PM
Hippo in Flies and Mammals: Signaling and Integration
Room: Chamisa Ballroom 1

Speaker 2 of 5
Jeffrey L. Wrana, Mount Sinai Hospital, Canada
Integration of Developmental Signaling Pathways

Monday, May 18 | 5:00PM - 7:00PM
Hippo in Flies and Mammals: Signaling and Integration
Room: Chamisa Ballroom 1

Speaker 3 of 5
Bin Zhao, Zhejiang University, China
Identification of a MicroRNA-Mediated Feed Forward Loop of the Hippo Pathway

Monday, May 18 | 5:00PM - 7:00PM
Hippo in Flies and Mammals: Signaling and Integration
Room: Chamisa Ballroom 1

Speaker 4 of 5
Helen McNeill, Lunenfeld-Tanenbaum Research Institute, Canada
Regulation of Epithelial Structure and Branching Morphogenesis in the Developing Mouse Kidney

Monday, May 18 | 5:00PM - 7:00PM
Hippo in Flies and Mammals: Signaling and Integration
Room: Chamisa Ballroom 1

Speaker 5 of 5
Christopher A. Johnston, University of New Mexico, USA
Short Talk: Warts Phosphorylates Mud to Promote Pins-Mediated Spindle Orientation in Drosophila

Monday, May 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
No registration fees are used to fund alcohol served at this function.

Monday, May 18 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Tuesday, May 19 | 7:30AM - 8:30AM
Breakfast
Room: Sagebrush Lobby & Cantina


Tuesday, May 19 | 8:30AM - 11:45AM
Transcriptional Outputs
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Kun-Liang Guan, University of California, San Diego, USA

Tuesday, May 19 | 8:30AM - 11:45AM
Transcriptional Outputs
Room: Chamisa Ballroom 1

Speaker 2 of 7
Stefano Piccolo, University of Padua, Italy
Transcriptional Control by YAP/TAZ

Tuesday, May 19 | 8:30AM - 11:45AM
Transcriptional Outputs
Room: Chamisa Ballroom 1

Speaker 3 of 7
Nicolas Tapon, Francis Crick Institute, UK
Growth Regulation by the Hippo Pathway

Tuesday, May 19 | 8:30AM - 11:45AM
Transcriptional Outputs
Room: Chamisa Ballroom 1

Speaker 4 of 7
Georg A. Halder, Katholieke Universiteit Leuven, Belgium
Regulation of the Hippo Pathway

Tuesday, May 19 | 8:30AM - 11:45AM
Transcriptional Outputs
Room: Chamisa Ballroom 1

Speaker 5 of 7
Fernando D. Camargo, Boston Children's Hospital, USA
Hippo/YAP Signaling in Somatic Stem Cells and Cancer

Tuesday, May 19 | 8:30AM - 11:45AM
Transcriptional Outputs
Room: Chamisa Ballroom 1

Speaker 6 of 7
Andrew G. Cox, Peter MacCallum Cancer Centre, Australia
Short Talk: Yap Reprograms Glutamine Metabolism and Supports Growth during Liver Development and Tumorigenesis

Tuesday, May 19 | 8:30AM - 11:45AM
Transcriptional Outputs
Room: Chamisa Ballroom 1

Speaker 7 of 7
Kenneth H. Moberg, Emory University School of Medicine, USA
Short Talk: The Ecdysone Receptor Coactivator Taiman Links Yorkie to Transcriptional Control of Germline Stem Cell Factors in Somatic Tissue

Tuesday, May 19 | 9:50AM - 10:10AM
Coffee Break
Room: Chamisa Lobby


Tuesday, May 19 | 11:45AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Tuesday, May 19 | 11:45AM - 2:30PM
On Own for Lunch


Tuesday, May 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Tuesday, May 19 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Hippo Regulation
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Kenneth Irvine, Rutgers University, USA

Tuesday, May 19 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Hippo Regulation
Room: Chamisa Ballroom 1

Speaker 2 of 7
Kieran F. Harvey, Peter MacCallum Cancer Centre, Australia
RNA Interference Screens: A Cautionary Tale from the Hippo Pathway

Tuesday, May 19 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Hippo Regulation
Room: Chamisa Ballroom 1

Speaker 3 of 7
Joe L. Kissil, The Scripps Research Institute, USA
The Role of YAP in Neurofibromatosis Type 2

Tuesday, May 19 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Hippo Regulation
Room: Chamisa Ballroom 1

Speaker 4 of 7
Cathie M. Pfleger, Mount Sinai School of Medicine, USA
Exploiting “Synthetic Lethality” Phenomena as Therapeutic Points of Entry in Hippo-Associated Cancers

Tuesday, May 19 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Hippo Regulation
Room: Chamisa Ballroom 1

Speaker 5 of 7
Sudha Veeraraghavan, University of Maryland, USA
Unexpected Insights into Hippo Signaling from the Crystal Structures of TEAD in Complex with Target DNA

Tuesday, May 19 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Hippo Regulation
Room: Chamisa Ballroom 1

Speaker 6 of 7
Aleksander D. Szymaniak, Boston University School of Medicine, USA
Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap

Tuesday, May 19 | 2:30PM - 4:30PM
Workshop: Emerging Concepts in Hippo Regulation
Room: Chamisa Ballroom 1

Speaker 7 of 7
Barry J. Thompson, Cancer Research UK, UK
The Spectrin Cytoskeleton Regulates the Hippo Pathway

Tuesday, May 19 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Tuesday, May 19 | 5:00PM - 7:00PM
Hippo Signaling in Stem Cells and Regeneration
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Helen McNeill, Lunenfeld-Tanenbaum Research Institute, Canada

Tuesday, May 19 | 5:00PM - 7:00PM
Hippo Signaling in Stem Cells and Regeneration
Room: Chamisa Ballroom 1

Speaker 2 of 5
Hiroshi Sasaki, Osaka University, Japan
Roles of Tead Family Proteins in Cell Competition in Mouse NIH3T3 Embryonic Fibroblasts

Tuesday, May 19 | 5:00PM - 7:00PM
Hippo Signaling in Stem Cells and Regeneration
Room: Chamisa Ballroom 1

Speaker 3 of 5
James F. Martin, Baylor College of Medicine, USA
Hippo Signaling in Heart Regeneration

Tuesday, May 19 | 5:00PM - 7:00PM
Hippo Signaling in Stem Cells and Regeneration
Room: Chamisa Ballroom 1

Speaker 4 of 5
Dae-Sik Lim, Korea Advanced Institute of Science and Technology, KAIST, South Korea
Hippo Signaling in Liver Development

Tuesday, May 19 | 5:00PM - 7:00PM
Hippo Signaling in Stem Cells and Regeneration
Room: Chamisa Ballroom 1

Speaker 5 of 5
Jennifer L. Cotton, Novartis Institutes for BioMedical Research, USA
Short Talk: Specific Requirement of YAP and TAZ in Mammalian Gastrointestinal Development

Tuesday, May 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
No registration fees are used to fund alcohol served at this function.

Tuesday, May 19 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Wednesday, May 20 | 7:30AM - 8:30AM
Breakfast
Room: Sagebrush Lobby & Cantina


Wednesday, May 20 | 8:30AM - 11:45AM
Hippo Pathway and Cancer Biology
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Kieran F. Harvey, Peter MacCallum Cancer Centre, Australia

Wednesday, May 20 | 8:30AM - 11:45AM
Hippo Pathway and Cancer Biology
Room: Chamisa Ballroom 1

Speaker 2 of 7
Helena E. Richardson, Peter MacCallum Cancer Centre, Australia
Polarity Control of Hippo Signaling in Tumorigenesis

Wednesday, May 20 | 8:30AM - 11:45AM
Hippo Pathway and Cancer Biology
Room: Chamisa Ballroom 1

Speaker 3 of 7
Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada
Phospho-Recognition in the Human Hippo Pathway

Wednesday, May 20 | 8:30AM - 11:45AM
Hippo Pathway and Cancer Biology
Room: Chamisa Ballroom 1

Speaker 4 of 7
Barry M. Gumbiner, University of Virginia School of Medicine, USA
Regulation of the Hippo Pathway by Adhesion Receptors

Wednesday, May 20 | 8:30AM - 11:45AM
Hippo Pathway and Cancer Biology
Room: Chamisa Ballroom 1

Speaker 5 of 7
Henning Wackerhage, University of Aberdeen, Scotland
Persistent YAP Hyperactivity Results in Mitotic Defects and Tumors with Complex Genomes

Wednesday, May 20 | 8:30AM - 11:45AM
Hippo Pathway and Cancer Biology
Room: Chamisa Ballroom 1

Speaker 6 of 7
Cecile Chartier, OncoMed Pharmaceuticals, USA
Short Talk: YAP Inhibits Tumor Growth through Potentiation of BMP Signaling

Wednesday, May 20 | 8:30AM - 11:45AM
Hippo Pathway and Cancer Biology
Room: Chamisa Ballroom 1

Speaker 7 of 7
Wenqi Wang, University of Texas MD Anderson Cancer Center, USA
Short Talk: Identify the Regulators for the Human Hippo Pathway

Wednesday, May 20 | 9:50AM - 10:10AM
Coffee Break
Room: Chamisa Lobby


Wednesday, May 20 | 11:45AM - 5:00PM
On Own for Lunch


Wednesday, May 20 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, May 20 | 5:00PM - 6:45PM
Drugging the Hippo Pathway
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Duojia D.J. Pan, HHMI/Johns Hopkins University School of Medicine, USA

Wednesday, May 20 | 5:00PM - 6:45PM
Drugging the Hippo Pathway
Room: Chamisa Ballroom 1

Speaker 2 of 4
Anwesha Dey, Genentech, Inc., USA
Targeting Hippo Pathway Members in Cancer

Wednesday, May 20 | 5:00PM - 6:45PM
Drugging the Hippo Pathway
Room: Chamisa Ballroom 1

Speaker 3 of 4
Wanjin Hong, Institute of Molecular and Cell Biology, Singapore
Targeting the Central Hydrophobic Pocket in TEAD Transcription Factors as a Cancer Therapeutic Strategy

Wednesday, May 20 | 5:00PM - 6:45PM
Drugging the Hippo Pathway
Room: Chamisa Ballroom 1

Speaker 4 of 4
Claudia Fromond, Inventiva, France
A Rational Approach for Discovery of Inhibitors of YAP-TEAD Interaction

Wednesday, May 20 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Chamisa Ballroom1


Wednesday, May 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2
No registration fees are used to fund alcohol served at this function.

Wednesday, May 20 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Wednesday, May 20 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Thursday, May 21 | 10:23AM - 10:23AM
Departure


*Session Chair
†Invited, not yet responded.