Web Desc
The Biological Code of Cell Signaling: A Tribute to Tony Pawson
Organizer(s): Tony Hunter and Rune Linding
Date: January 11 - 16, 2015
Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA
Sponsored by the Journal of Molecular Cell Biology (JMCB), Regeneron Pharmaceuticals, Inc., Roche and Thermo Fisher Scientific Inc.
Summary of Meeting:
Prompted by the recent loss of one of the brightest stars in the life sciences, this Keystone Symposia meeting has been designed to honor the memory of Tony Pawson. The aim of the meeting is to provide a forward-looking symposium rooted in his prodigious scientific legacy. It constitutes a natural evolution of previous symposia he organized (such as the “Omics Meets Cell Biology” series and “The Evolution of Protein Phosphorylation”). As such, the scientific focus of the symposium is on the role of post-translational modifications (PTMs), modular protein domains and signaling networks as driving forces of human evolution and disease. The cellular world that Tony, with others, unlocked consists of dynamic protein networks created through the interactions of different protein modules, which together drive almost every intra- and inter-cellular decision process we know today. His most important contribution in this field is undoubtedly his discovery of the first protein interaction module, the SH2 domain, but numerous other interaction domains followed, leading to current investigations of how the dysregulation of these networks leads to new signaling states in disease that are critical for processes in, for instance, cancer, such as tumor progression, or drug resistance. The symposium thus spans the entire spectrum of fields that have been touched by Tony Pawson's prolific and inspiring research, while maintaining a strong forward-looking perspective.
Scholarship Deadline: September 23 2014
Discounted Abstract Deadline: September 23 2014
Abstract Deadline: October 15 2014
Discounted Registration Deadline: November 12 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Journal of Molecular Cell Biology (JMCB)Regeneron Pharmaceuticals, Inc.RocheThermo Fisher Scientific Inc.
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
PLOS
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 11 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Sunday, January 11 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Foyer/Rainbow/Twilight


Monday, January 12 | 8:00AM - 11:00AM
Tony Pawson: More than 35 Years of Research Discovery
Room: Storm Peak/Mt. Werner
Opening session providing a global overview of Tony's scientific legacy by scientists who can deliver personal, exciting and emotional retrospectives, mixed with an overview of their own research.
Speaker 1 of 7
* Rune Linding, University of Copenhagen, Denmark

Monday, January 12 | 8:00AM - 11:00AM
Tony Pawson: More than 35 Years of Research Discovery
Room: Storm Peak/Mt. Werner
Opening session providing a global overview of Tony's scientific legacy by scientists who can deliver personal, exciting and emotional retrospectives, mixed with an overview of their own research.
Speaker 2 of 7
Tony Hunter, The Salk Institute for Biological Sciences, USA
A Tale of Two Tonys: Forty Years of Scientific Crosstalk

Monday, January 12 | 8:00AM - 11:00AM
Tony Pawson: More than 35 Years of Research Discovery
Room: Storm Peak/Mt. Werner
Opening session providing a global overview of Tony's scientific legacy by scientists who can deliver personal, exciting and emotional retrospectives, mixed with an overview of their own research.
Speaker 3 of 7
Alan Bernstein, Canadian Institute for Advanced Research, Canada
Tony Pawson: Wonderful Scientist, Colleague and True Friend

Monday, January 12 | 8:00AM - 11:00AM
Tony Pawson: More than 35 Years of Research Discovery
Room: Storm Peak/Mt. Werner
Opening session providing a global overview of Tony's scientific legacy by scientists who can deliver personal, exciting and emotional retrospectives, mixed with an overview of their own research.
Speaker 4 of 7
John D. Scott, University of Washington, USA
Guiding Signals through Anchored Enzyme Complexes

Monday, January 12 | 8:00AM - 11:00AM
Tony Pawson: More than 35 Years of Research Discovery
Room: Storm Peak/Mt. Werner
Opening session providing a global overview of Tony's scientific legacy by scientists who can deliver personal, exciting and emotional retrospectives, mixed with an overview of their own research.
Speaker 5 of 7
Nina Jones, University of Guelph, Canada
Short Talk: Phosphotyrosine Signaling at the Kidney Slit Diaphragm

Monday, January 12 | 8:00AM - 11:00AM
Tony Pawson: More than 35 Years of Research Discovery
Room: Storm Peak/Mt. Werner
Opening session providing a global overview of Tony's scientific legacy by scientists who can deliver personal, exciting and emotional retrospectives, mixed with an overview of their own research.
Speaker 6 of 7
Marius Sudol, National University of Singapore, Singapore
Poster Talk: Signaling by WW and SH2 Domain-Containing Proteins

Monday, January 12 | 8:00AM - 11:00AM
Tony Pawson: More than 35 Years of Research Discovery
Room: Storm Peak/Mt. Werner
Opening session providing a global overview of Tony's scientific legacy by scientists who can deliver personal, exciting and emotional retrospectives, mixed with an overview of their own research.
Speaker 7 of 7
Arthur Weiss, University of California, San Francisco, USA
Intercellular Signaling by Transmembrane Proteins

Monday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, January 12 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine/Rainbow/Twilight


Monday, January 12 | 11:00AM - 5:00PM
On Own for Lunch


Monday, January 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine/Rainbow/Twilight


Monday, January 12 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, January 12 | 5:00PM - 7:00PM
Modular Protein Domains - Past, Present and Future
Room: Storm Peak/Mt. Werner
From SH2 to all other building blocks of signaling networks.
Speaker 1 of 4
Peer Bork, European Molecular Biology Laboratory, Germany
Predicting Biological Function at Different Spatial Scales

Monday, January 12 | 5:00PM - 7:00PM
Modular Protein Domains - Past, Present and Future
Room: Storm Peak/Mt. Werner
From SH2 to all other building blocks of signaling networks.
Speaker 2 of 4
Sachdev S. Sidhu, University of Toronto, Canada
Modulation of Cell Signaling with Synthetic Proteins

Monday, January 12 | 5:00PM - 7:00PM
Modular Protein Domains - Past, Present and Future
Room: Storm Peak/Mt. Werner
From SH2 to all other building blocks of signaling networks.
Speaker 3 of 4
Toby Gibson, European Molecular Biology Laboratory, Germany
Regulation by Molecular Switching

Monday, January 12 | 5:00PM - 7:00PM
Modular Protein Domains - Past, Present and Future
Room: Storm Peak/Mt. Werner
From SH2 to all other building blocks of signaling networks.
Speaker 4 of 4
* Bruce J. Mayer, University of Connecticut Health Center, USA
SH2 Domains Three Ways: The Dynamics of Receptor Tyrosine Kinase Signaling

Monday, January 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer/Rainbow/Twilight
No registration fees are used to fund alcohol served at this function.

Monday, January 12 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunshine/Rainbow/Twilight


Tuesday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Foyer/Rainbow/Twilight


Tuesday, January 13 | 8:00AM - 11:00AM
Protein Modules and Drugs
Room: Storm Peak/Mt. Werner
How to perturb domains and target them for medical intervention.
Speaker 1 of 6
* Giulio Superti-Furga, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Integration of Individual Signaling Domains into Increasingly Complex Layers of Regulation: From the ABL Tyrosine Kinase to the Mechanism of Action of Anticancer Drugs

Tuesday, January 13 | 8:00AM - 11:00AM
Protein Modules and Drugs
Room: Storm Peak/Mt. Werner
How to perturb domains and target them for medical intervention.
Speaker 2 of 6
Shohei Koide, New York University Langone Health, USA
Poster Talk: Controlling Signaling Networks with Monobody Inhibitors against Modular Interaction Domains

Tuesday, January 13 | 8:00AM - 11:00AM
Protein Modules and Drugs
Room: Storm Peak/Mt. Werner
How to perturb domains and target them for medical intervention.
Speaker 3 of 6
Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Genetic Variability and the Quantitative Proteome

Tuesday, January 13 | 8:00AM - 11:00AM
Protein Modules and Drugs
Room: Storm Peak/Mt. Werner
How to perturb domains and target them for medical intervention.
Speaker 4 of 6
Frank Sicheri, Lunenfeld-Tanenbaum Research Institute, Canada
Structural Basis for Poly-Ubiquitin Chain Cleavage: Lessons Learned from OTUB1 and OTULIN/Gumby

Tuesday, January 13 | 8:00AM - 11:00AM
Protein Modules and Drugs
Room: Storm Peak/Mt. Werner
How to perturb domains and target them for medical intervention.
Speaker 5 of 6
Xiaolei Su, University of California, San Francisco, USA
Poster Talk: Reconstituting TCR Signaling Pathways Reveals a Role for T Cell Microclusters

Tuesday, January 13 | 8:00AM - 11:00AM
Protein Modules and Drugs
Room: Storm Peak/Mt. Werner
How to perturb domains and target them for medical intervention.
Speaker 6 of 6
Vishva M. Dixit, Genentech, Inc., USA
Ubiquitin Modification in Cancer Pathogenesis

Tuesday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, January 13 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine/Rainbow/Twilight


Tuesday, January 13 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine/Rainbow/Twilight


Tuesday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, January 13 | 5:00PM - 7:00PM
Kinome Biology
Room: Storm Peak/Mt. Werner
Kinase signaling networks - phosphorylation-based signaling.
Speaker 1 of 5
* Benjamin E. Turk, Yale University, USA
Large-Scale Analysis of Protein Kinase Specificity

Tuesday, January 13 | 5:00PM - 7:00PM
Kinome Biology
Room: Storm Peak/Mt. Werner
Kinase signaling networks - phosphorylation-based signaling.
Speaker 2 of 5
Stefan Knapp, University of Oxford, UK
Short Talk: Selective Targeting of Kinase Signaling Networks

Tuesday, January 13 | 5:00PM - 7:00PM
Kinome Biology
Room: Storm Peak/Mt. Werner
Kinase signaling networks - phosphorylation-based signaling.
Speaker 3 of 5
Rune Linding, University of Copenhagen, Denmark
Biological Forecasting in the Cancer Kinome

Tuesday, January 13 | 5:00PM - 7:00PM
Kinome Biology
Room: Storm Peak/Mt. Werner
Kinase signaling networks - phosphorylation-based signaling.
Speaker 4 of 5
Edward Y. Skolnik, New York University Medical Center, USA
Poster Talk: Regulation of Pancreatic b Cells by Protein Histidine Phosphorylation


Tuesday, January 13 | 5:00PM - 7:00PM
Kinome Biology
Room: Storm Peak/Mt. Werner
Kinase signaling networks - phosphorylation-based signaling.
Speaker 5 of 5
Susan S. Taylor, University of California, San Diego, USA
PKA: Evolution of a Dynamic Macromolecular Switch

Tuesday, January 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer/Rainbow/Twilight
No registration fees are used to fund alcohol served at this function.

Tuesday, January 13 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunshine/Rainbow/Twilight


Wednesday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Foyer/Rainbow/Twilight


Wednesday, January 14 | 8:00AM - 11:00AM
From Modules and Networks to Cellular Phenotypes
Room: Storm Peak/Mt. Werner
How changes in protein modules and signaling networks translate into cellular switches.
Speaker 1 of 6
Norbert Perrimon, Harvard Medical School, USA
Spatio-Temporal Regulation of Signaling in Drosophila

Wednesday, January 14 | 8:00AM - 11:00AM
From Modules and Networks to Cellular Phenotypes
Room: Storm Peak/Mt. Werner
How changes in protein modules and signaling networks translate into cellular switches.
Speaker 2 of 6
* John Kuriyan, University of California, Berkeley, USA
Control of Catalytic Activity in the EGF Receptor

Wednesday, January 14 | 8:00AM - 11:00AM
From Modules and Networks to Cellular Phenotypes
Room: Storm Peak/Mt. Werner
How changes in protein modules and signaling networks translate into cellular switches.
Speaker 3 of 6
Ivan Dikic, Goethe University Medical School, Germany
Linear Ubiquitination in Regulation of Inflammation

Wednesday, January 14 | 8:00AM - 11:00AM
From Modules and Networks to Cellular Phenotypes
Room: Storm Peak/Mt. Werner
How changes in protein modules and signaling networks translate into cellular switches.
Speaker 4 of 6
Michael Tyers, Canada
From Large Networks to Small Molecules

Wednesday, January 14 | 8:00AM - 11:00AM
From Modules and Networks to Cellular Phenotypes
Room: Storm Peak/Mt. Werner
How changes in protein modules and signaling networks translate into cellular switches.
Speaker 5 of 6
Lee Bardwell, University of California, Irvine, USA
Poster Talk: Synergy, Interdependency and Redundancy in Multi-Site Phosphorylation

Wednesday, January 14 | 8:00AM - 11:00AM
From Modules and Networks to Cellular Phenotypes
Room: Storm Peak/Mt. Werner
How changes in protein modules and signaling networks translate into cellular switches.
Speaker 6 of 6
James E. Ferrell Jr., Stanford University, USA
Trigger Waves in Mitosis and Apoptosis

Wednesday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, January 14 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine/Rainbow/Twilight


Wednesday, January 14 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine/Rainbow/Twilight


Wednesday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, January 14 | 5:00PM - 7:00PM
Evolution of Phosphorylation, PTMs and Modular Protein Domai
ns

Room: Storm Peak/Mt. Werner
How cells evolved to function the way they do
Speaker 1 of 5
* Gerard Manning, Genentech, Inc., USA
Evolutionary Comparisons to Explore the Function and Diversity of Signaling Biology

Wednesday, January 14 | 5:00PM - 7:00PM
Evolution of Phosphorylation, PTMs and Modular Protein Domai
ns

Room: Storm Peak/Mt. Werner
How cells evolved to function the way they do
Speaker 2 of 5
Chris Tan, CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Short Talk: Co-Evolution of Protein Phosphorylation and Protein-Protein Interaction Networks

Wednesday, January 14 | 5:00PM - 7:00PM
Evolution of Phosphorylation, PTMs and Modular Protein Domai
ns

Room: Storm Peak/Mt. Werner
How cells evolved to function the way they do
Speaker 3 of 5
Liam J. Holt, University of California, Berkeley, USA
Poster Talk: Ancestral Resurrection Reveals Evolutionary Mechanisms of Kinase Plasticity

Wednesday, January 14 | 5:00PM - 7:00PM
Evolution of Phosphorylation, PTMs and Modular Protein Domai
ns

Room: Storm Peak/Mt. Werner
How cells evolved to function the way they do
Speaker 4 of 5
Benjamin G. Neel, Ontario Cancer Institute, Canada
PTP1B Promotes Survival of HER2+ Breast Cancer in Hypoxia by Regulating Moyamoya Disease-Associated E3 Ligase, RNF213 and Cellular Dioxygenase Activity

Wednesday, January 14 | 5:00PM - 7:00PM
Evolution of Phosphorylation, PTMs and Modular Protein Domai
ns

Room: Storm Peak/Mt. Werner
How cells evolved to function the way they do
Speaker 5 of 5
Robert Rottapel, Princess Margaret Hospital, Toronto Medical Discovery Tower, Canada
Short Talk: Abl Mediates a TAZ:RUNZ2 Self-Reinforcing Feedback Loop Required for Osteoblastogenesis

Wednesday, January 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer/Rainbow/Twilight
No registration fees are used to fund alcohol served at this function.

Wednesday, January 14 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunshine/Rainbow/Twilight


Thursday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Foyer/Rainbow/Twilight


Thursday, January 15 | 8:00AM - 11:00AM
Network Medicine - Targeting Signaling Networks
Room: Storm Peak/Mt. Werner
Relating knowledge of signaling networks to advances in patients' outcomes.
Speaker 1 of 6
* Michael B. Yaffe, Massachusetts Institute of Technology, USA
Using Systems Biology to Target Cancer

Thursday, January 15 | 8:00AM - 11:00AM
Network Medicine - Targeting Signaling Networks
Room: Storm Peak/Mt. Werner
Relating knowledge of signaling networks to advances in patients' outcomes.
Speaker 2 of 6
Douglas A. Lauffenburger, Massachusetts Institute of Technology, USA
Crosstalk and Feedback in Receptor Tyrosine Kinase Signaling Networks

Thursday, January 15 | 8:00AM - 11:00AM
Network Medicine - Targeting Signaling Networks
Room: Storm Peak/Mt. Werner
Relating knowledge of signaling networks to advances in patients' outcomes.
Speaker 3 of 6
Ruth H. Palmer, University of Gothenburg, Sweden
Poster Talk: Investigation of Anaplastic Lymphoma Kinase Signaling

Thursday, January 15 | 8:00AM - 11:00AM
Network Medicine - Targeting Signaling Networks
Room: Storm Peak/Mt. Werner
Relating knowledge of signaling networks to advances in patients' outcomes.
Speaker 4 of 6
Johannes L. Bos, University Medical Center Utrecht, Netherlands
Targeting Spatial and Temporal Control of Endothelial Barrier Function

Thursday, January 15 | 8:00AM - 11:00AM
Network Medicine - Targeting Signaling Networks
Room: Storm Peak/Mt. Werner
Relating knowledge of signaling networks to advances in patients' outcomes.
Speaker 5 of 6
Oliver Hantschel, Swiss Federal Institute of Technology Lausanne, Switzerland
Poster Talk: The SH2 Domain of ABL Kinases Regulates Kinase Autophosphorylation by Controlling Activation Loop Accessibility

Thursday, January 15 | 8:00AM - 11:00AM
Network Medicine - Targeting Signaling Networks
Room: Storm Peak/Mt. Werner
Relating knowledge of signaling networks to advances in patients' outcomes.
Speaker 6 of 6
Michael K. Rosen, University of Texas Southwestern Medical Center, USA
Phase Separation of Multi-Valent Signaling Proteins

Thursday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, January 15 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, January 15 | 5:00PM - 7:00PM
Signaling Networks Driving Disease Progression and Resistanc
e to Drugs

Room: Storm Peak/Mt. Werner
Current limitations in our understanding of disease progression and potential solutions.
Speaker 1 of 3
* Joan S. Brugge, Harvard Medical School, USA
Signaling Pathways that Regulate Adaptive Resistance to Cancer Therapies

Thursday, January 15 | 5:00PM - 7:00PM
Signaling Networks Driving Disease Progression and Resistanc
e to Drugs

Room: Storm Peak/Mt. Werner
Current limitations in our understanding of disease progression and potential solutions.
Speaker 2 of 3
Richard M. Marais, Cancer Research UK Manchester Institute, UK
NRAS and BRAF Signaling in Melanoma: From Basic Biology to Clinical Efficacy

Thursday, January 15 | 5:00PM - 7:00PM
Signaling Networks Driving Disease Progression and Resistanc
e to Drugs

Room: Storm Peak/Mt. Werner
Current limitations in our understanding of disease progression and potential solutions.
Speaker 3 of 3
Clark D. Wells, Indiana University School of Medicine, USA
Differential Roles of Angiomotin Proteins in the Development of Breast Cancer

Thursday, January 15 | 7:00PM - 7:30PM
Closing Remarks: Tony Pawson's Legacy
Room: Storm Peak/Mt. Werner

Speaker 1 of 2
* Tony Hunter, The Salk Institute for Biological Sciences, USA

Thursday, January 15 | 7:00PM - 7:30PM
Closing Remarks: Tony Pawson's Legacy
Room: Storm Peak/Mt. Werner

Speaker 2 of 2
* Rune Linding, University of Copenhagen, Denmark

Thursday, January 15 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Foyer/Rainbow/Twilight
No registration fees are used to fund alcohol served at this function.

Thursday, January 15 | 8:00PM - 11:00PM
Entertainment
Room: Sunshine
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, January 15 | 8:45PM - 11:00PM
Cash Bar
Room: Sunshine


Friday, January 16 | 10:25AM - 10:25AM
Departure


*Session Chair.