Web Desc
Integrating Metabolism and Tumor Biology
joint with PI 3-Kinase Signaling Pathways in Disease
Organizer(s): Ralph J. DeBerardinis, Robert T. Abraham and Eyal Gottlieb
Date: January 13 - 18, 2015
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Sponsored by Astellas Pharma Inc., Bayer HealthCare Pharmaceuticals, Cell Signaling Technology, Inc., ImmunoGen, Inc., Pfizer Inc. and Takeda Pharmaceutical Company
Summary of Meeting:
Work in recent years has demonstrated extensive interconnectivity between oncogenic signaling pathways and intermediate metabolism. Compelling evidence indicates that signaling aberrations that drive oncogenesis trigger extensive alterations in metabolic flux; conversely, mutational alterations in certain metabolic enzymes are capable of priming cells for malignancy. These observations have raised hopes that understanding the metabolic underpinnings of cellular transformation, tumor growth and metastasis will result in more effective strategies to diagnose and treat cancer. Current challenges include understanding how best to translate observations from simple models of tumor cell growth to bona fide tumors in vivo, and understanding which aspects of dysregulated cell metabolism contribute to tumor maintenance and progression. This conference will bring together scientists from academia and industry attacking this problem on many levels. A major theme of the meeting will be exploring the cross-talk between metabolism and various other dimensions of systems biology, including epigenetics, protein function, stress responses and signal transduction. Emerging principles regarding the influence of the tumor microenvironment on cellular metabolism will be discussed in detail, as will new progress toward exploiting metabolic reprogramming to image and treat cancer. The meeting is paired with one on “PI 3-Kinase Signaling Pathways in Disease,” providing a fertile environment for exchange of ideas between these two highly connected fields.
Scholarship Deadline: September 24 2014
Discounted Abstract Deadline: September 24 2014
Abstract Deadline: October 16 2014
Discounted Registration Deadline: November 13 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Astellas Pharma Inc.Bayer HealthCare PharmaceuticalsCell Signaling Technology, Inc.ImmunoGen, Inc.Pfizer Inc.Takeda Pharmaceutical Company Limited
We gratefully acknowledge additional support for this conference from:
CEDARLANEHypOxygenSeahorse Bioscience, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline

Pfizer Global Research & Development
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
PLOS
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA189443-01
Funding for this conference was made possible (in part) by 1R13CA189443-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 13 | 4:00PM - 8:00PM
Arrival and Registration
Room: British/Columbia Foyer


Tuesday, January 13 | 6:00PM - 8:00PM
Welcome Mixer
Room: British/Columbia Foyer
No registration fees are used to fund alcohol served at this function.

Wednesday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Wednesday, January 14 | 8:00AM - 9:00AM
Keynote Address (Joint)
Room: British/Columbia Ballroom

Speaker 1 of 1
Lewis C. Cantley, Weill Cornell Medicine, USA
Phosphoinositide Kinases and Cancer Metabolism

Wednesday, January 14 | 9:00AM - 11:15AM
Oncogenic Control of Metabolism (Joint)
Room: British/Columbia Ballroom

Speaker 1 of 5
* Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA

Wednesday, January 14 | 9:00AM - 11:15AM
Oncogenic Control of Metabolism (Joint)
Room: British/Columbia Ballroom

Speaker 2 of 5
Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy
PI3K Class II gamma Is a Rab5 Effector Selectively Controlling Endosomal Akt2 Activation Downstream Insulin Signaling

Wednesday, January 14 | 9:00AM - 11:15AM
Oncogenic Control of Metabolism (Joint)
Room: British/Columbia Ballroom

Speaker 3 of 5
John Blenis, Weill Cornell Medical College, USA
mTOR Control of Glutamine Metabolism

Wednesday, January 14 | 9:00AM - 11:15AM
Oncogenic Control of Metabolism (Joint)
Room: British/Columbia Ballroom

Speaker 4 of 5
David M. Sabatini, Whitehead Institute for Biomedical Research, USA
mTOR and the Cell Biology of Nutrient Sensing

Wednesday, January 14 | 9:00AM - 11:15AM
Oncogenic Control of Metabolism (Joint)
Room: British/Columbia Ballroom

Speaker 5 of 5
Wei-Xing Zong, Rutgers University, USA
Short Talk: Myc Induces Expression of Glutamine Synthetase through Thymine DNA Glycosylase-Mediated Promoter Demethylation

Wednesday, January 14 | 9:40AM - 10:00AM
Coffee Break
Room: British/Columbia Foyer


Wednesday, January 14 | 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Wednesday, January 14 | 11:45AM - 2:30PM
On Own for Lunch


Wednesday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Wednesday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Wednesday, January 14 | 5:00PM - 7:00PM
Metabolic Perturbations that Drive Malignancy
Room: British Ballroom

Speaker 1 of 4
* Eyal Gottlieb, Technion - Israel Institute of Technology, Israel

Wednesday, January 14 | 5:00PM - 7:00PM
Metabolic Perturbations that Drive Malignancy
Room: British Ballroom

Speaker 2 of 4
Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Role of Glycolytic Regulation in Tumor Biology

Wednesday, January 14 | 5:00PM - 7:00PM
Metabolic Perturbations that Drive Malignancy
Room: British Ballroom

Speaker 3 of 4
Julie-Aurore Losman, Dana-Farber Cancer Institute, USA
2-Hydroxyglutarate Induces a Reversible State of Malignant Transformation

Wednesday, January 14 | 5:00PM - 7:00PM
Metabolic Perturbations that Drive Malignancy
Room: British Ballroom

Speaker 4 of 4
Binhua (Peter) P. Zhou, University of Kentucky College of Medicine, USA
Metabolic Facilitators of the Epithelial-Mesenchymal Transition

Wednesday, January 14 | 5:00PM - 7:15PM
PI3K Effectors

This session is from PI 3-Kinase
Room: Columbia Ballroom
Proteins that Bind PI3K Lipid Products: Function in Cancer and Immune Disease.
Speaker 1 of 6
* Roger L. Williams, Medical Research Council, UK


Wednesday, January 14 | 5:00PM - 7:15PM
PI3K Effectors

This session is from PI 3-Kinase
Room: Columbia Ballroom
Proteins that Bind PI3K Lipid Products: Function in Cancer and Immune Disease.
Speaker 2 of 6
Alex Toker, Beth Israel Deaconess Medical Center, USA
PI 3-Kinase and Akt at the Interface of Signaling and Metabolism


Wednesday, January 14 | 5:00PM - 7:15PM
PI3K Effectors

This session is from PI 3-Kinase
Room: Columbia Ballroom
Proteins that Bind PI3K Lipid Products: Function in Cancer and Immune Disease.
Speaker 3 of 6
Yoshinori Fukui, Medical Institute of Bioregulation, Kyushu University, Japan
Critical Roles of DOCK Family Proteins in Migration and Activation of Leukocytes


Wednesday, January 14 | 5:00PM - 7:15PM
PI3K Effectors

This session is from PI 3-Kinase
Room: Columbia Ballroom
Proteins that Bind PI3K Lipid Products: Function in Cancer and Immune Disease.
Speaker 4 of 6
Aaron J. Marshall, University of Manitoba, Canada
Short Talk: Phosphatidylinositol 3,4 Bisphosphate and its Binding Protein Lammellipodin Are Required for Directional Migration of Malignant B Cells


Wednesday, January 14 | 5:00PM - 7:15PM
PI3K Effectors

This session is from PI 3-Kinase
Room: Columbia Ballroom
Proteins that Bind PI3K Lipid Products: Function in Cancer and Immune Disease.
Speaker 5 of 6
Sonja Vermeren, University of Edinburgh, UK
PI3K Regulates Integrin-Dependent Processes in the Neutrophil by Signaling through ARAP3


Wednesday, January 14 | 5:00PM - 7:15PM
PI3K Effectors

This session is from PI 3-Kinase
Room: Columbia Ballroom
Proteins that Bind PI3K Lipid Products: Function in Cancer and Immune Disease.
Speaker 6 of 6
Ming O. Li, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling


Wednesday, January 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom
No registration fees are used to fund alcohol served at this function.

Wednesday, January 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Thursday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Thursday, January 15 | 8:00AM - 11:15AM
Mitochondrial Metabolism and Cancer
Room: British Ballroom

Speaker 1 of 8
* Marcia C. Haigis, Harvard Medical School, USA

Thursday, January 15 | 8:00AM - 11:15AM
Mitochondrial Metabolism and Cancer
Room: British Ballroom

Speaker 2 of 8
Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Conventional and Unconventional Roles of Mitochondrial Enzymes in Tumor Cell Metabolism

Thursday, January 15 | 8:00AM - 11:15AM
Mitochondrial Metabolism and Cancer
Room: British Ballroom

Speaker 3 of 8
Paul Hwang, NHLBI, National Institutes of Health, USA
Role of TP53 in Regulating Mitochondrial Metabolism

Thursday, January 15 | 8:00AM - 11:15AM
Mitochondrial Metabolism and Cancer
Room: British Ballroom

Speaker 4 of 8
John C. Schell, University of Utah, USA
Short Talk: The Mitochondrial Pyruvate Carrier Enforces the Warburg Effect and Is Important for Cancer-Initiating Cell Maintenance

Thursday, January 15 | 8:00AM - 11:15AM
Mitochondrial Metabolism and Cancer
Room: British Ballroom

Speaker 5 of 8
Pierre Sonveaux, University of Louvain, Belgium
Short Talk: A Mitochondrial Switch Promotes Tumor Metastasis

Thursday, January 15 | 8:00AM - 11:15AM
Mitochondrial Metabolism and Cancer
Room: British Ballroom

Speaker 6 of 8
Navdeep S. Chandel, Northwestern University, USA
Mitochondrial Metabolism Regulates Cell Proliferation and Epigenetics

Thursday, January 15 | 8:00AM - 11:15AM
Mitochondrial Metabolism and Cancer
Room: British Ballroom

Speaker 7 of 8
Andre Catic, Baylor College of Medicine, USA
Short Talk: Nuclear Proteolysis as a Metabolic Regulator

Thursday, January 15 | 8:00AM - 11:15AM
Mitochondrial Metabolism and Cancer
Room: British Ballroom

Speaker 8 of 8
Roger Geiger, Institute for Research in Biomedicine, Switzerland
Short Talk: Influence of L-Arginine on Metabolic Networks and the Lifespan of Activated T Cells

Thursday, January 15 | 8:00AM - 11:15AM
PI3K/Akt/mTOR in Immune Function, Inflammation
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 1 of 7
* Bart Vanhaesebroeck, University College London, Cancer Institute, UK


Thursday, January 15 | 8:00AM - 11:15AM
PI3K/Akt/mTOR in Immune Function, Inflammation
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 2 of 7
Phillip T. Hawkins, Babraham Institute, UK
PI3K Signaling in Neutrophils


Thursday, January 15 | 8:00AM - 11:15AM
PI3K/Akt/mTOR in Immune Function, Inflammation
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 3 of 7
Klaus Okkenhaug, University of Cambridge, UK
PI3Kdelta in Immunity, Infection and Cancer


Thursday, January 15 | 8:00AM - 11:15AM
PI3K/Akt/mTOR in Immune Function, Inflammation
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 4 of 7
Judith A. Varner, University of California, San Diego, USA
Short Talk: Targeting PI3Kgamma Activates Anti-Tumor Immune Responses and Promotes Cancer Survival


Thursday, January 15 | 8:00AM - 11:15AM
PI3K/Akt/mTOR in Immune Function, Inflammation
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 5 of 7
David A. Fruman, University of California, Irvine, USA
Insights Concerning the Selective Action of Rapamycin in Lymphocytes


Thursday, January 15 | 8:00AM - 11:15AM
PI3K/Akt/mTOR in Immune Function, Inflammation
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 6 of 7
Robert C. Rickert, Pfizer Inc., USA
The PI3K Pathway in B Cell Metabolism


Thursday, January 15 | 8:00AM - 11:15AM
PI3K/Akt/mTOR in Immune Function, Inflammation
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 7 of 7
Yina H. Huang, Dartmouth College, USA
Short Talk: Calmodulin and PI(3,4,5)P3 Cooperatively Bind to the Itk Pleckstrin Homology Domain to Promote Efficient Calcium Signaling and IL-17A Production in T Cells


Thursday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: British/Columbia Foyer


Thursday, January 15 | 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Thursday, January 15 | 11:15AM - 2:30PM
On Own for Lunch


Thursday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Thursday, January 15 | 2:30PM - 4:30PM
Workshop 1: Novel Targets and Pathways
Room: British Ballroom

Speaker 1 of 8
* Costas A. Lyssiotis, University of Michigan, USA

Thursday, January 15 | 2:30PM - 4:30PM
Workshop 1: Novel Targets and Pathways
Room: British Ballroom

Speaker 2 of 8
Serkan Kir, Dana-Farber Cancer Institute, USA
Tumor-Derived PTH-Related Protein Triggers Adipose Tissue Browning and Cancer Cachexia

Thursday, January 15 | 2:30PM - 4:30PM
Workshop 1: Novel Targets and Pathways
Room: British Ballroom

Speaker 3 of 8
Saverio Tardito, Beatson Institute for Cancer Research, UK
De novo Purine Biosynthesis Dictates Glutamine Dependency of Glioblastoma Cells

Thursday, January 15 | 2:30PM - 4:30PM
Workshop 1: Novel Targets and Pathways
Room: British Ballroom

Speaker 4 of 8
Jiyeon Kim, University of Texas Southwestern Medical Center, USA
Unconventional Pathways of Nitrogen Metabolism in Lung Cancer

Thursday, January 15 | 2:30PM - 4:30PM
Workshop 1: Novel Targets and Pathways
Room: British Ballroom

Speaker 5 of 8
Jonathan L. Coloff, University of Illinois at Chicago, USA
Regulation of Glutamine Metabolism in Epithelial Cell Proliferation and Quiescence

Thursday, January 15 | 2:30PM - 4:30PM
Workshop 1: Novel Targets and Pathways
Room: British Ballroom

Speaker 6 of 8
Atsuo T. Sasaki, University of Cincinnati, USA
SSK1, a Novel GTP-Dependent Kinase, Detects GTP Levels and Regulates Tumorigenesis

Thursday, January 15 | 2:30PM - 4:30PM
Workshop 1: Novel Targets and Pathways
Room: British Ballroom

Speaker 7 of 8
Etienne Audet-Walsh, McGill University, Canada
The Estrogen-Related Receptor Gamma Is a Key Determinant of Androgens-Mediated Energy Reprogramming of Prostate Cancer Cells

Thursday, January 15 | 2:30PM - 4:30PM
Workshop 1: Novel Targets and Pathways
Room: British Ballroom

Speaker 8 of 8
Zhimin Lu, University of Texas MD Anderson Cancer Center, USA
Phosphoglycerate Kinase 1 Coordinates Glycolysis and TCA Cycle in Tumorigenesis

Thursday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Thursday, January 15 | 5:00PM - 7:00PM
Model Organisms as Tools to Understand Metabolism, Growth an
d Cancer

Room: British Ballroom

Speaker 1 of 5
* David M. Sabatini, Whitehead Institute for Biomedical Research, USA

Thursday, January 15 | 5:00PM - 7:00PM
Model Organisms as Tools to Understand Metabolism, Growth an
d Cancer

Room: British Ballroom

Speaker 2 of 5
Benjamin Tu, University of Texas Southwestern Medical Center, USA
What is TORC1 doing to Cellular Metabolism?

Thursday, January 15 | 5:00PM - 7:00PM
Model Organisms as Tools to Understand Metabolism, Growth an
d Cancer

Room: British Ballroom

Speaker 3 of 5
Alex Gould, Francis Crick Institute, UK
Protecting Neural Stem Cells from Starvation and Hypoxia in Drosophila

Thursday, January 15 | 5:00PM - 7:00PM
Model Organisms as Tools to Understand Metabolism, Growth an
d Cancer

Room: British Ballroom

Speaker 4 of 5
Gabriela David, Baylor College of Medicine, USA
Short Talk: Wacky Is a Novel Regulator of mTOR Signaling

Thursday, January 15 | 5:00PM - 7:00PM
Model Organisms as Tools to Understand Metabolism, Growth an
d Cancer

Room: British Ballroom

Speaker 5 of 5
Leonard I. Zon, HHMI/Boston Children's Hospital, USA
The Role of Nucleotide Deficiency in the Transcriptional Regulation of Neural Crest Differentiation and Melanoma

Thursday, January 15 | 5:00PM - 7:15PM
PI3K in Cancer
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 1 of 5
Lori Friedman, ORIC Pharmaceuticals, USA
Sensitivity and Resistance to PI3K Pathway Inhibitors


Thursday, January 15 | 5:00PM - 7:15PM
PI3K in Cancer
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 2 of 5
Vuk Stambolic, University Health Network, Canada
Nuclear PTEN Function in Tumor Suppression


Thursday, January 15 | 5:00PM - 7:15PM
PI3K in Cancer
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 3 of 5
* Jean J. Zhao, Dana-Farber Cancer Institute, USA
Targeting PI3K Isoforms in Cancer: Mechanistic and Therapeutic Insights from Genetic Mouse Models


Thursday, January 15 | 5:00PM - 7:15PM
PI3K in Cancer
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 4 of 5
Inma M. Berenjeno, University College London, Cancer Institute, UK
Short Talk: Induction of Chromosomal Instability by Oncogenic PIK3CA and its Possible Implications


Thursday, January 15 | 5:00PM - 7:15PM
PI3K in Cancer
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 5 of 5
Miguel Murillo, Institute of Cancer Research, UK
Short Talk: Disruption of the Interaction of RAS with PI3K p110alpha Induces Regression of EGFR-Driven Lung Tumors


Thursday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom
No registration fees are used to fund alcohol served at this function.

Thursday, January 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Pacific Ballroom


Friday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Friday, January 16 | 7:30AM - 8:00AM
Poster Setup
Room: Pacific Ballroom


Friday, January 16 | 8:00AM - 5:00PM
Poster Viewing
Room: Pacific Ballroom


Friday, January 16 | 8:00AM - 11:15AM
Targeting Cancer Cell Metabolism
Room: British Ballroom

Speaker 1 of 8
* Michael Pollak, Jewish General Hospital, Canada

Friday, January 16 | 8:00AM - 11:15AM
Targeting Cancer Cell Metabolism
Room: British Ballroom

Speaker 2 of 8
Robert J. Gillies, H. Lee Moffitt Cancer Center and Research Institute, USA
Buffer Therapy

Friday, January 16 | 8:00AM - 11:15AM
Targeting Cancer Cell Metabolism
Room: British Ballroom

Speaker 3 of 8
Deepak Nagrath, University of Michigan, USA
Short Talk: Deconstructing Glutamine’s Role in Regulating Aggressiveness, Drug Sensitivity in Ovarian Cancer Cells

Friday, January 16 | 8:00AM - 11:15AM
Targeting Cancer Cell Metabolism
Room: British Ballroom

Speaker 4 of 8
Kate Yen, Auron Therapeutics, USA
Targeting Mutant IDH in Cancer

Friday, January 16 | 8:00AM - 11:15AM
Targeting Cancer Cell Metabolism
Room: British Ballroom

Speaker 5 of 8
Reuben J. Shaw, The Salk Institute for Biological Studies, USA
The LKB1 - AMPK Tumor Suppressor Pathway: Metabolic Reprogramming and Therapeutic Targeting

Friday, January 16 | 8:00AM - 11:15AM
Targeting Cancer Cell Metabolism
Room: British Ballroom

Speaker 6 of 8
Russell G. Jones, Van Andel Research Institute, USA
Short Talk: The Oncogenic MicroRNA miR-17-92 Regulates Tumor Metabolism through Suppression of LKB1-AMPK Signaling

Friday, January 16 | 8:00AM - 11:15AM
Targeting Cancer Cell Metabolism
Room: British Ballroom

Speaker 7 of 8
Gina DeNicola, Moffitt Cancer Center, USA
Short Talk: NRF2 Regulates Serine Biosynthesis in Non-Small Cell Lung Cancer

Friday, January 16 | 8:00AM - 11:15AM
Targeting Cancer Cell Metabolism
Room: British Ballroom

Speaker 8 of 8
Dohoon Kim, University of Massachusetts Medical School, USA
Short Talk: SHMT2 Drives Glioma Cell Survival in the Tumor Microenvironment but Imposes a Dependence on Glycine Clearance

Friday, January 16 | 8:00AM - 11:00AM
PI3K/Akt/mTOR Clinical Translational - Oncology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 1 of 7
* Lori Friedman, ORIC Pharmaceuticals, USA


Friday, January 16 | 8:00AM - 11:00AM
PI3K/Akt/mTOR Clinical Translational - Oncology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 2 of 7
José Baselga, Memorial Sloan-Kettering Cancer Center, USA
PI3K and mTOR Inhibitors in Breast Cancer


Friday, January 16 | 8:00AM - 11:00AM
PI3K/Akt/mTOR Clinical Translational - Oncology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 3 of 7
Jerry Y. Hsu, Genentech, Inc., USA
Clinical Development of PI3K Inhibitors at Genentech: Is There Clinical Proof of Concept with this Class of Agents in Solid Tumors?


Friday, January 16 | 8:00AM - 11:00AM
PI3K/Akt/mTOR Clinical Translational - Oncology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 4 of 7
Jeffery L. Kutok, Epizyme, Inc., USA
Short Talk: Duvelisib Inhibits Malignant B-Cell Proliferation and Disrupts Signaling from the Tumor Microenvironment through Mechanisms that are Dependent on PI3K-delta and PI3K-gamma


Friday, January 16 | 8:00AM - 11:00AM
PI3K/Akt/mTOR Clinical Translational - Oncology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 5 of 7
Arthur L. Shaffer III, NCI, National Institutes of Health, USA
Short Talk: Mechanisms of Ibrutinib Resistance in the Aggressive, ABC-subtype of Diffuse Large B Cell Lymphoma: PI3K and Pathways to new Therapeutic Options


Friday, January 16 | 8:00AM - 11:00AM
PI3K/Akt/mTOR Clinical Translational - Oncology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 6 of 7
Timothy Richard Wilson, Genentech, Inc., USA
Short Talk: Biomarker Analysis from a Phase I Dose Escalation Study of Taselisib (GDC-0032), a beta Isoform-Sparing PI3K Inhibitor


Friday, January 16 | 8:00AM - 11:00AM
PI3K/Akt/mTOR Clinical Translational - Oncology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 7 of 7
Michel Maira, Basilea Pharamceutica Int., Switzerland
PI3K Inhibitors for Cancer Treatment: Translational Research and Beyond


Friday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: British/Columbia Foyer


Friday, January 16 | 11:15AM - 12:00PM
Lunch
Room: Pacific Ballroom


Friday, January 16 | 12:00PM - 2:30PM
Poster Session 3
Room: Pacific Ballroom


Friday, January 16 | 2:30PM - 4:30PM
Workshop 2: Strategies for Discovery of Therapeutic Targets
and Metabolism-Targeted Drugs
Room: British Ballroom

Speaker 1 of 7
* Arkaitz Carracedo, Center for Cooperative Research in Biosciences, Spain

Friday, January 16 | 2:30PM - 4:30PM
Workshop 2: Strategies for Discovery of Therapeutic Targets
and Metabolism-Targeted Drugs
Room: British Ballroom

Speaker 2 of 7
Michael E. Pacold, New York University Medical Center, USA
Selective Toxicity of a 3-Phosphoglycerate Dehydrogenase Inhibitor towards PHGDH-Dependent Cells in vitro and in vivo

Friday, January 16 | 2:30PM - 4:30PM
Workshop 2: Strategies for Discovery of Therapeutic Targets
and Metabolism-Targeted Drugs
Room: British Ballroom

Speaker 3 of 7
Jing Chen, Winship Cancer Institute, Emory University, USA
Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling

Friday, January 16 | 2:30PM - 4:30PM
Workshop 2: Strategies for Discovery of Therapeutic Targets
and Metabolism-Targeted Drugs
Room: British Ballroom

Speaker 4 of 7
Robert U. Svensson, The Salk Institute for Biological Studies, USA
Acetyl-CoA Carboxylase Inhibition by ND646 Reduces Fatty Acid Synthesis and Inhibits Tumor Growth of Human Non-Small Cell Lung Cancer Cells

Friday, January 16 | 2:30PM - 4:30PM
Workshop 2: Strategies for Discovery of Therapeutic Targets
and Metabolism-Targeted Drugs
Room: British Ballroom

Speaker 5 of 7
Hector C. Keun, Imperial College London, UK
MCT1-Dependent Lactate Utilisation Is an Adaptive Response that Maintains Tumor Cell Proliferation, Lipogenesis and Redox Balance under Glucose Deprivation

Friday, January 16 | 2:30PM - 4:30PM
Workshop 2: Strategies for Discovery of Therapeutic Targets
and Metabolism-Targeted Drugs
Room: British Ballroom

Speaker 6 of 7
Ayelet Erez, Weizmann Institute of Science, Israel
Aspartate Metabolism Links the Urea Cycle with Nucleic Acid Synthesis in Cancerous Proliferation

Friday, January 16 | 2:30PM - 4:30PM
Workshop 2: Strategies for Discovery of Therapeutic Targets
and Metabolism-Targeted Drugs
Room: British Ballroom

Speaker 7 of 7
Chiara Gorrini, Campbell Family Institute for Breast Cancer Research, Canada
BRCA1-Associated Tumorigenesis: A Matter of ROS Balance

Friday, January 16 | 2:30PM - 4:30PM
Workshop 1: PI3K Structure and Enzymology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 1 of 7
* Jonathan M. Backer, Albert Einstein College of Medicine, USA


Friday, January 16 | 2:30PM - 4:30PM
Workshop 1: PI3K Structure and Enzymology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 2 of 7
Takehiko Sasaki, Tokyo Medical and Dental University, Japan
A New Methodology for Studying Phosphoinositide Signaling at the Molecular Species Level


Friday, January 16 | 2:30PM - 4:30PM
Workshop 1: PI3K Structure and Enzymology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 3 of 7
John E. Burke, University of Victoria, Canada
Deciphering the Dynamic Regulation of Phosphoinositide Kinases on Membrane Surfaces


Friday, January 16 | 2:30PM - 4:30PM
Workshop 1: PI3K Structure and Enzymology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 4 of 7
Natasha S. Clayton, University of Cambridge, UK
Regulation of PI3K Activity by Activated Cdc42-Associated Kinase (ACK)


Friday, January 16 | 2:30PM - 4:30PM
Workshop 1: PI3K Structure and Enzymology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 5 of 7
Christl Gaubitz, University of Geneva, Switzerland
Structural basis of the Rapamycin Insensitivity of Target of Rapamycin Complex 2


Friday, January 16 | 2:30PM - 4:30PM
Workshop 1: PI3K Structure and Enzymology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 6 of 7
Goran Stjepanovic, University of California, Berkeley, USA
Architecture and Dynamics of the Autophagic Phosphatidylinositol 3-Kinase Complex


Friday, January 16 | 2:30PM - 4:30PM
Workshop 1: PI3K Structure and Enzymology
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 7 of 7
Oscar Vadas, University of Geneva, Switzerland
Regulation of PI3Kgamma Downstream of GPCRs


Friday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Friday, January 16 | 5:00PM - 7:30PM
Metabolite Control of Gene Expression and Protein Function
Room: British Ballroom

Speaker 1 of 6
* Matthew D. Hirschey, Duke University, USA

Friday, January 16 | 5:00PM - 7:30PM
Metabolite Control of Gene Expression and Protein Function
Room: British Ballroom

Speaker 2 of 6
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Metabolic Control of Epigenetics in Cancer

Friday, January 16 | 5:00PM - 7:30PM
Metabolite Control of Gene Expression and Protein Function
Room: British Ballroom

Speaker 3 of 6
Christine A. Parachoniak, Massachusetts General Hospital Cancer Center, USA
Short Talk: Mutant IDH Blocks Murine Primary Liver Progenitor Cell Differentiation to Drive Liver Cancer Pathogenesis

Friday, January 16 | 5:00PM - 7:30PM
Metabolite Control of Gene Expression and Protein Function
Room: British Ballroom

Speaker 4 of 6
Eric M. Verdin, Buck Institute for Research on Aging, USA
Mitochondrial Protein Acylation and the Sirtuins


Friday, January 16 | 5:00PM - 7:30PM
Metabolite Control of Gene Expression and Protein Function
Room: British Ballroom

Speaker 5 of 6
Marcia C. Haigis, Harvard Medical School, USA
Post-Translational Modifications and Control of Mitochondrial Metabolism

Friday, January 16 | 5:00PM - 7:30PM
Metabolite Control of Gene Expression and Protein Function
Room: British Ballroom

Speaker 6 of 6
Poul H. B. Sorensen, University of British Columbia, Canada
The eEF2K Translation Factor and Metabolic Reprogramming in Tumor Cells

Friday, January 16 | 5:00PM - 7:15PM
PI3K/Akt/mTOR Clinical Translational - Inflammation
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 1 of 6
* David A. Fruman, University of California, Irvine, USA


Friday, January 16 | 5:00PM - 7:15PM
PI3K/Akt/mTOR Clinical Translational - Inflammation
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 2 of 6
Stephen Shuttleworth, Karus Therapeutics, UK
Design and Development of New Class of PI3K-p110beta/delta Inhibitors for the Treatment of Immune-Inflammatory Disease


Friday, January 16 | 5:00PM - 7:15PM
PI3K/Akt/mTOR Clinical Translational - Inflammation
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 3 of 6
Augustin Amour, GlaxoSmithKline, UK
The Development of a Promising Inhaled PI3Kdelta Inhibitor for the Treatment of Respiratory Indications


Friday, January 16 | 5:00PM - 7:15PM
PI3K/Akt/mTOR Clinical Translational - Inflammation
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 4 of 6
Alison Mary Condliffe, University of Sheffield, UK
Activated PI3 Kinase Delta Syndrome (APDS): A Novel Combined Immunodeficiency Disorder


Friday, January 16 | 5:00PM - 7:15PM
PI3K/Akt/mTOR Clinical Translational - Inflammation
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 5 of 6
Carrie L. Lucas, Yale University, USA
Short Talk: Lymphoproliferation and CD8 T Cell Senescence in Primary Human Immunodeficiencies caused by Gene Mutations that Activate PI3K Signaling


Friday, January 16 | 5:00PM - 7:15PM
PI3K/Akt/mTOR Clinical Translational - Inflammation
This session is from PI 3-Kinase
Room: Columbia Ballroom

Speaker 6 of 6
Yan-xia Ye, Peking Union Medical College Hospital, China
Short Talk: Defective PTEN Regulation and Function Contributes to B Cell Hyper-Responsiveness in Systemic Lupus Erythematosus


Friday, January 16 | 7:30PM - 7:30PM
On Own for Dinner


Saturday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Saturday, January 17 | 8:00AM - 11:15AM
Metabolic Consequences of Cell Stress
Room: British Ballroom

Speaker 1 of 7
* Robert T. Abraham, Vividion Therapeutics, USA

Saturday, January 17 | 8:00AM - 11:15AM
Metabolic Consequences of Cell Stress
Room: British Ballroom

Speaker 2 of 7
Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Autophagy, Metabolism and Cancer

Saturday, January 17 | 8:00AM - 11:15AM
Metabolic Consequences of Cell Stress
Room: British Ballroom

Speaker 3 of 7
Eyal Gottlieb, Technion - Israel Institute of Technology, Israel
Pyruvate Carboxylation Is Required for Growth of Succinate Dehydrogenase-Deficient Cells

Saturday, January 17 | 8:00AM - 11:15AM
Metabolic Consequences of Cell Stress
Room: British Ballroom

Speaker 4 of 7
Karen H. Vousden, Francis Crick Institute, UK
A Role for p53 in the Regulation of Metabolism

Saturday, January 17 | 8:00AM - 11:15AM
Metabolic Consequences of Cell Stress
Room: British Ballroom

Speaker 5 of 7
Kun-Liang Guan, University of California, San Diego, USA
The Hippo-YAP Pathway in Organ Size Control and Tumorigenesis

Saturday, January 17 | 8:00AM - 11:15AM
Metabolic Consequences of Cell Stress
Room: British Ballroom

Speaker 6 of 7
Andrew M. Intlekofer, Memorial Sloan Kettering Cancer Center, USA
Short Talk: L-2-Hydroxyglutarate Production in Response to Hypoxic Stress

Saturday, January 17 | 8:00AM - 11:15AM
Metabolic Consequences of Cell Stress
Room: British Ballroom

Speaker 7 of 7
Bo Li, Sun Yat-sen University, China
Short Talk: Fructose-1,6-Bisphosphatase Opposes Renal Carcinoma Progression

Saturday, January 17 | 8:00AM - 11:15AM
Class II/III PI3K, Trafficking
This session is from PI 3-Kinase
Room: Columbia Ballroom
Linking Vps34 Regulation of Trafficking with Other Sessions - Autophagy, Metabolism.
Speaker 1 of 7
* Phillip T. Hawkins, Babraham Institute, UK


Saturday, January 17 | 8:00AM - 11:15AM
Class II/III PI3K, Trafficking
This session is from PI 3-Kinase
Room: Columbia Ballroom
Linking Vps34 Regulation of Trafficking with Other Sessions - Autophagy, Metabolism.
Speaker 2 of 7
Bart Vanhaesebroeck, University College London, Cancer Institute, UK
New Physiological Roles of PI3K Isoforms


Saturday, January 17 | 8:00AM - 11:15AM
Class II/III PI3K, Trafficking
This session is from PI 3-Kinase
Room: Columbia Ballroom
Linking Vps34 Regulation of Trafficking with Other Sessions - Autophagy, Metabolism.
Speaker 3 of 7
Volker Haucke, Leibniz Forschungsinstitut für Molekulare Pharmakologie, Germany
Spatiotemporal control of endocytosis and endosomal membrane traffic by PI 3-phosphates


Saturday, January 17 | 8:00AM - 11:15AM
Class II/III PI3K, Trafficking
This session is from PI 3-Kinase
Room: Columbia Ballroom
Linking Vps34 Regulation of Trafficking with Other Sessions - Autophagy, Metabolism.
Speaker 4 of 7
Nadia L. Jaber, Stony Brook University, USA
Short Talk: Vps34 Controls Rab7 to Regulate Endocytic Trafficking


Saturday, January 17 | 8:00AM - 11:15AM
Class II/III PI3K, Trafficking
This session is from PI 3-Kinase
Room: Columbia Ballroom
Linking Vps34 Regulation of Trafficking with Other Sessions - Autophagy, Metabolism.
Speaker 5 of 7
Sharon A. Tooze, Francis Crick Institute, UK
The Role of PI3P and WIPI2 in Autophagy


Saturday, January 17 | 8:00AM - 11:15AM
Class II/III PI3K, Trafficking
This session is from PI 3-Kinase
Room: Columbia Ballroom
Linking Vps34 Regulation of Trafficking with Other Sessions - Autophagy, Metabolism.
Speaker 6 of 7
Gilbert Di Paolo, Denali Therapeutics Inc., USA
Dysregulation of Class III PI3K/Vps34 Signaling in Neurons Recapitulates Key Features of Alzheimer's Disease


Saturday, January 17 | 8:00AM - 11:15AM
Class II/III PI3K, Trafficking
This session is from PI 3-Kinase
Room: Columbia Ballroom
Linking Vps34 Regulation of Trafficking with Other Sessions - Autophagy, Metabolism.
Speaker 7 of 7
Svetlana A. Fayngerts, Adaptimmune LLC, USA
Short Talk: Of Cell Life and Death: The Phosphoinositide Transfer Domain of the TNFAIP8 Family


Saturday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: British/Columbia Foyer


Saturday, January 17 | 11:15AM - 2:30PM
On Own for Lunch


Saturday, January 17 | 2:30PM - 4:30PM
Joint Workshop: Autophagy and Regulation of Anabolic/Catabol
ic Balance (Joint)
Room: British/Columbia Ballroom

Speaker 1 of 9
* Leon O. Murphy, Casma Therapeutics, USA

Saturday, January 17 | 2:30PM - 4:30PM
Joint Workshop: Autophagy and Regulation of Anabolic/Catabol
ic Balance (Joint)
Room: British/Columbia Ballroom

Speaker 2 of 9
* Daniel J. Murphy, University of Glasgow, UK

Saturday, January 17 | 2:30PM - 4:30PM
Joint Workshop: Autophagy and Regulation of Anabolic/Catabol
ic Balance (Joint)
Room: British/Columbia Ballroom

Speaker 3 of 9
Rushika M. Perera, University of California, San Francisco, USA
Transcriptional Control of the Autophagy-Lysosome System Drives Amino Acid Metabolism in Pancreatic Cancer

Saturday, January 17 | 2:30PM - 4:30PM
Joint Workshop: Autophagy and Regulation of Anabolic/Catabol
ic Balance (Joint)
Room: British/Columbia Ballroom

Speaker 4 of 9
Assia Shisheva, Wayne State University School of Medicine, USA
Class III PI 3-Kinase Is the Main Source of PtdIns3P Substrate and Membrane Recruitment Signal for PIKfyve Constitutive Function in Endomembrane Homeostasis

Saturday, January 17 | 2:30PM - 4:30PM
Joint Workshop: Autophagy and Regulation of Anabolic/Catabol
ic Balance (Joint)
Room: British/Columbia Ballroom

Speaker 5 of 9
Aimee L. Edinger, University of California, Irvine, USA
Sphingolipid Drugs that Starve Cancer Cells from Inside and Out

Saturday, January 17 | 2:30PM - 4:30PM
Joint Workshop: Autophagy and Regulation of Anabolic/Catabol
ic Balance (Joint)
Room: British/Columbia Ballroom

Speaker 6 of 9
Masayuki Noguchi, Hokkaido University, Japan
The Links between AKT and Two Intracellular Proteolytic Cascades: Ubiquitination and Autophagy

Saturday, January 17 | 2:30PM - 4:30PM
Joint Workshop: Autophagy and Regulation of Anabolic/Catabol
ic Balance (Joint)
Room: British/Columbia Ballroom

Speaker 7 of 9
Julien Planchais, INSERM U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes, France
The Glucose-Responsive Transcription Factor ChREBP Enhances Glucose-Dependent Anabolic Biosynthesis and Hepatocyte Proliferation in a PI3K/Akt Dependent Manner

Saturday, January 17 | 2:30PM - 4:30PM
Joint Workshop: Autophagy and Regulation of Anabolic/Catabol
ic Balance (Joint)
Room: British/Columbia Ballroom

Speaker 8 of 9
Michael Pollak, Jewish General Hospital, Canada
Serine Deprivation Enhances Anti-Neoplastic Activity of Biguanides

Saturday, January 17 | 2:30PM - 4:30PM
Joint Workshop: Autophagy and Regulation of Anabolic/Catabol
ic Balance (Joint)
Room: British/Columbia Ballroom

Speaker 9 of 9
Biplab Dasgupta, Cincinnati Children's Hospital, USA
AMP Kinase: Evolving Lessons about its Context-Dependent Opposite Roles in Cancer

Saturday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: British/Columbia Foyer


Saturday, January 17 | 5:00PM - 6:45PM
Influence of the Metabolic Environment on Cancer Development
and Tumor Growth

Room: British Ballroom

Speaker 1 of 4
* Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA

Saturday, January 17 | 5:00PM - 6:45PM
Influence of the Metabolic Environment on Cancer Development
and Tumor Growth

Room: British Ballroom

Speaker 2 of 4
Dafna Bar-Sagi, New York University School of Medicine, USA
Oncogenic Ras-Mediated Metabolic Adaptation

Saturday, January 17 | 5:00PM - 6:45PM
Influence of the Metabolic Environment on Cancer Development
and Tumor Growth

Room: British Ballroom

Speaker 3 of 4
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipokines and Tumor Progression

Saturday, January 17 | 5:00PM - 6:45PM
Influence of the Metabolic Environment on Cancer Development
and Tumor Growth

Room: British Ballroom

Speaker 4 of 4
Robert T. Abraham, Vividion Therapeutics, USA
Glutamine Deprivation Stimulates a Stress-Response Network in Cancer Cells

Saturday, January 17 | 5:00PM - 6:45PM
PI3K Structure and Regulation
This session is from PI 3-Kinase
Room: Columbia Ballroom
Insights into Structure of PI3K Enzymes, Inhibitor Binding, and Other Modes of Regulation.
Speaker 1 of 4
* John E. Burke, University of Victoria, Canada


Saturday, January 17 | 5:00PM - 6:45PM
PI3K Structure and Regulation
This session is from PI 3-Kinase
Room: Columbia Ballroom
Insights into Structure of PI3K Enzymes, Inhibitor Binding, and Other Modes of Regulation.
Speaker 2 of 4
Roger L. Williams, Medical Research Council, UK
Structural Insights into Vps34 Regulation


Saturday, January 17 | 5:00PM - 6:45PM
PI3K Structure and Regulation
This session is from PI 3-Kinase
Room: Columbia Ballroom
Insights into Structure of PI3K Enzymes, Inhibitor Binding, and Other Modes of Regulation.
Speaker 3 of 4
Leon O. Murphy, Casma Therapeutics, USA
Generation of Selective VPS34 Inhibitors to Probe the Autophagy Pathway


Saturday, January 17 | 5:00PM - 6:45PM
PI3K Structure and Regulation
This session is from PI 3-Kinase
Room: Columbia Ballroom
Insights into Structure of PI3K Enzymes, Inhibitor Binding, and Other Modes of Regulation.
Speaker 4 of 4
Jonathan M. Backer, Albert Einstein College of Medicine, USA
The Complex Functions of p110beta: A Critical Integrator of Signals from GPCRs and Small GTPases.


Saturday, January 17 | 6:45PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: British Ballroom


Saturday, January 17 | 6:45PM - 7:15PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
This session is from PI 3-Kinase
Room: Columbia Ballroom


Saturday, January 17 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Pacific Ballroom
No registration fees are used to fund alcohol served at this function.

Saturday, January 17 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Saturday, January 17 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Sunday, January 18 | 10:25AM - 10:25AM
Departure


*Session Chair.