Web Desc
Host Response in Tuberculosis
joint with Granulomas in Infectious and Non-Infectious Diseases
Organizer(s): JoAnne L. Flynn and Willem A. Hanekom
Date: January 22 - 27, 2015
Location: Santa Fe Community Convention Center, Santa Fe, NM, USA
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Tuberculosis remains a major cause of morbidity and mortality globally. Control of the epidemic is hampered by limited understanding of basic processes underlying disease and protection. This symposium will focus on basic science in humans; major themes will include immune processes that have emerged as important for pathogenesis or protection. Translation of basic science advances into novel strategies to prevent and manage human tuberculosis will also be discussed. While preclinical progress will be addressed throughout the meeting, emphasis of direct relevance to human tuberculosis will be part of each presentation. The meeting will be held jointly with a Keystone Symposia meeting on “Granulomas in Infectious and Non-Infectious Diseases.” Granulomas are a pathologic hallmark of tuberculosis, so the pairing of these two meetings will enhance opportunities for interdisciplinary interactions and for learning about other granulomatous systems and providing insights into how this knowledge may be applied to our understanding of tuberculosis. The specific aims for this meeting are to: 1) Gather scientists interested in basic pathogenesis and immunologic responses in tuberculosis to present and discuss cutting-edge tuberculosis research; 2) Integrate basic and clinical research findings with a view to improving treatment and prevention of disease in humans; 3) Provide mentoring opportunities for junior scientists with senior scientists interested in tuberculosis research; and 4) Focus on gaps in knowledge about the events in natural infection, as well as vulnerability points for intervening in the infection process.
Global Health Travel Award Deadline: August 19 2014
Scholarship Deadline: September 29 2014
Discounted Abstract Deadline: September 29 2014
Abstract Deadline: October 22 2014
Discounted Registration Deadline: November 20 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bill & Melinda Gates Foundation
$2,500 - $9,999
Tuberculosis (published by Elsevier)
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
PLOS
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI114099-01
Funding for this conference was made possible (in part) by 1 R13 AI 114099 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, January 22 | 4:00PM - 8:00PM
Arrival and Registration
Room: Sweeney Ballroom Foyer


Thursday, January 22 | 6:00PM - 8:00PM
Welcome Mixer
Room: Sweeney F
No registration fees are used to fund alcohol served at this function.

Friday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Friday, January 23 | 7:30AM - 8:00AM
Poster Setup
Room: Sweeney F, Main Level Breakouts


Friday, January 23 | 8:00AM - 5:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakouts


Friday, January 23 | 8:00AM - 9:00AM
Keynote Address
Room: Sweeney Ballroom A-D
Setting the stage for addressing tuberculosis from a human perspective--from basic to clinical research.
Speaker 1 of 2
* JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA

Friday, January 23 | 8:00AM - 9:00AM
Keynote Address
Room: Sweeney Ballroom A-D
Setting the stage for addressing tuberculosis from a human perspective--from basic to clinical research.
Speaker 2 of 2
Clifton E. Barry III, NIAID, National Institutes of Health, USA
Human Tuberculosis: The Movie

Friday, January 23 | 9:00AM - 11:15AM
Immunity in the Lung
Room: Sweeney Ballroom A-D
Events in the airway and interactions with early cells influence outcome.
Speaker 1 of 5
* Alan Sher, NIAID, National Institutes of Health, USA

Friday, January 23 | 9:00AM - 11:15AM
Immunity in the Lung
Room: Sweeney Ballroom A-D
Events in the airway and interactions with early cells influence outcome.
Speaker 2 of 5
David M. Lewinsohn, Oregon Health & Science University, USA
MAITs and Protection Against TB

Friday, January 23 | 9:00AM - 11:15AM
Immunity in the Lung
Room: Sweeney Ballroom A-D
Events in the airway and interactions with early cells influence outcome.
Speaker 3 of 5
Henry Charles Mwandumba, Liverpool School of Tropical Medicine, UK
TB/HIV Interactions in the Airways

Friday, January 23 | 9:00AM - 11:15AM
Immunity in the Lung
Room: Sweeney Ballroom A-D
Events in the airway and interactions with early cells influence outcome.
Speaker 4 of 5
Gerhard Walzl, Stellenbosch University, South Africa
Human TB Treatment Response Studies Using PET/CT Imaging: Inconvenient Observations

Friday, January 23 | 9:00AM - 11:15AM
Immunity in the Lung
Room: Sweeney Ballroom A-D
Events in the airway and interactions with early cells influence outcome.
Speaker 5 of 5
Wendy A. Burgers, University of Cape Town, South Africa
Short Talk: Defects in Multiple Mycobacterial T Helper Subsets in Blood and Lungs in Early HIV Infection

Friday, January 23 | 9:00AM - 11:15AM
Granulomas Associated with Type-1 Immunity
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 1 of 4
Paul Kaye, University of York, UK
Understanding Granuloma Heterogeneity in Visceral Leishmaniasis


Friday, January 23 | 9:00AM - 11:15AM
Granulomas Associated with Type-1 Immunity
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 2 of 4
Martin Rottenberg, Karolinska Institutet, Sweden
SOCS3 in either Myeloid or T Cells Conveys Resistance to Infection with Mycobacterium tuberculosis


Friday, January 23 | 9:00AM - 11:15AM
Granulomas Associated with Type-1 Immunity
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 3 of 4
Jean-Laurent Casanova, Rockefeller University, USA
Toward a Genetic Theory of Childhood Infectious Diseases


Friday, January 23 | 9:00AM - 11:15AM
Granulomas Associated with Type-1 Immunity
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 4 of 4
Evelina Guirado, Ohio State University, USA
Short Talk: Characterization of Host and Microbial Determinants in Individuals with Latent Tuberculosis Infection Using a Human Granuloma Model


Friday, January 23 | 9:40AM - 10:00AM
Coffee Break
Room: Sweeney Ballroom Foyer


Friday, January 23 | 11:15AM - 12:15PM
Lunch


Friday, January 23 | 12:00PM - 2:30PM
Poster Session 1
Room: Sweeney F, Main Level Breakouts


Friday, January 23 | 2:30PM - 4:30PM
Workshop: Novel Approaches to Treatment of Tuberculosis
Room: Sweeney Ballroom A-D

Speaker 1 of 9
* Christopher M. Sassetti, University of Massachusetts Medical School, USA

Friday, January 23 | 2:30PM - 4:30PM
Workshop: Novel Approaches to Treatment of Tuberculosis
Room: Sweeney Ballroom A-D

Speaker 2 of 9
* Brian C. VanderVen, Cornell University, USA
Chemical Screening against Mycobacterium tuberculosis in Macrophages Identifies Inhibitors of Cholesterol Utilization

Friday, January 23 | 2:30PM - 4:30PM
Workshop: Novel Approaches to Treatment of Tuberculosis
Room: Sweeney Ballroom A-D

Speaker 3 of 9
Frederick K. Balagaddé, K-RITH KwaZulu-Natal Research Institute for TB & HIV, South Africa
Confinement-Induced Drug-Tolerance in Microfluidic Bioreactors

Friday, January 23 | 2:30PM - 4:30PM
Workshop: Novel Approaches to Treatment of Tuberculosis
Room: Sweeney Ballroom A-D

Speaker 4 of 9
Robert Blomgran, Linköping University, Sweden
Pharmacological Inhibition of mTORC1 Is Not the Treatment for HIV Mycobacterium tuberculosis Co-Infection

Friday, January 23 | 2:30PM - 4:30PM
Workshop: Novel Approaches to Treatment of Tuberculosis
Room: Sweeney Ballroom A-D

Speaker 5 of 9
Meenal Datta, Massachusetts General Hospital/Harvard Medical School, USA
Anti-VEGF Treatment Normalizes Tuberculosis Granuloma Vasculature and Improves Small Molecule Delivery

Friday, January 23 | 2:30PM - 4:30PM
Workshop: Novel Approaches to Treatment of Tuberculosis
Room: Sweeney Ballroom A-D

Speaker 6 of 9
Scott M. Irwin, Colorado State University, USA
Bedaquiline and its Metabolite Display Reduced Penetration into Caseous Necrotic Pulmonary Lesions in C3HeB/FeJ Mice

Friday, January 23 | 2:30PM - 4:30PM
Workshop: Novel Approaches to Treatment of Tuberculosis
Room: Sweeney Ballroom A-D

Speaker 7 of 9
Ekta Lachmandas, Radboud University Medical Center, Netherlands
Rewiring of Cellular Metabolism via the AKT/mTOR Pathway Forms the Basis of Host Defense against Mycobacterium tuberculosis

Friday, January 23 | 2:30PM - 4:30PM
Workshop: Novel Approaches to Treatment of Tuberculosis
Room: Sweeney Ballroom A-D

Speaker 8 of 9
Tige R. Rustad, Seattle BioMed, USA
The Wiring Diagram of Mycobacterium tuberculosis: Generating and Using an Experimentally-Derived Transcriptional Regulatory Map

Friday, January 23 | 2:30PM - 4:30PM
Workshop: Novel Approaches to Treatment of Tuberculosis
Room: Sweeney Ballroom A-D

Speaker 9 of 9
Suraj P. Parihar, University of Cape Town, South Africa
Role of Statins against Mycobacterium tuberculosis Infection

Friday, January 23 | 2:30PM - 4:30PM
Workshop 1: Basic Biology
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 1 of 6
* Matyas Sandor, University of Wisconsin, USA


Friday, January 23 | 2:30PM - 4:30PM
Workshop 1: Basic Biology
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 2 of 6
Matthew McPeek, East Carolina University, USA
MicroRNAs Targeting PPAR? Pathways Are Elevated in Bronchoalveolar Lavage (BAL) Cells from Sarcoidosis Patients and from Mice Bearing Carbon Nanotube Induced Granulomas


Friday, January 23 | 2:30PM - 4:30PM
Workshop 1: Basic Biology
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 3 of 6
Marie Lipoldova, Institute of Molecular Genetics, Czech Republic
Analysis of Granuloma Formation and Characteristics Using Defined Genomic Constructs


Friday, January 23 | 2:30PM - 4:30PM
Workshop 1: Basic Biology
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 4 of 6
Deepak Kaushal, Texas Biomedical Research Institute, USA
Role of Sensor Kinase DosS in Virulence of Mycobacterium tuberculosis in C3HeB/FeJ Mice with Classical Granulomatous Lesions


Friday, January 23 | 2:30PM - 4:30PM
Workshop 1: Basic Biology
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 5 of 6
Teresa A. Hudock, Tulane National Primate Research Center, USA
Transcriptome Analysis of Mycobacterium tuberculosis in Primate Lung Granulomas


Friday, January 23 | 2:30PM - 4:30PM
Workshop 1: Basic Biology
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 6 of 6
Albert Byungyun Jeon, Colorado State University, USA
Reversal of Phenotypic and Genotypic Antimicrobial Drug Resistance in Mycobacterium tuberculosis with 2 Aminoimadazole-Based Small Molecule Adjuvants


Friday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom Foyer


Friday, January 23 | 5:00PM - 7:00PM
Early Events after TB Infection
Room: Sweeney Ballroom A-D
Early events in the infectious process.
Speaker 1 of 5
* Henry Charles Mwandumba, Liverpool School of Tropical Medicine, UK

Friday, January 23 | 5:00PM - 7:00PM
Early Events after TB Infection
Room: Sweeney Ballroom A-D
Early events in the infectious process.
Speaker 2 of 5
Thomas R. Hawn, University of Washington, USA
Innate Immunogenetics of TB in Humans

Friday, January 23 | 5:00PM - 7:00PM
Early Events after TB Infection
Room: Sweeney Ballroom A-D
Early events in the infectious process.
Speaker 3 of 5
Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy in Tuberculosis

Friday, January 23 | 5:00PM - 7:00PM
Early Events after TB Infection
Room: Sweeney Ballroom A-D
Early events in the infectious process.
Speaker 4 of 5
Sabine Ehrt, Weill Cornell Medical College, USA
Survival in the Phagosome: Resist to Persist

Friday, January 23 | 5:00PM - 7:00PM
Early Events after TB Infection
Room: Sweeney Ballroom A-D
Early events in the infectious process.
Speaker 5 of 5
Ludovic P. Desvignes, New York University School of Medicine, USA
Short Talk: Dynamics of Early Growth and Spread of Mycobacterium tuberculosis in vivo Reveal Sequential Infection of Myeloid Cell Populations

Friday, January 23 | 5:00PM - 7:00PM
Infectious and Non-Infectious Granulomatous Disease
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 1 of 5
* Paul Kaye, University of York, UK


Friday, January 23 | 5:00PM - 7:00PM
Infectious and Non-Infectious Granulomatous Disease
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 2 of 5
Margherita T. Cantorna, Pennsylvania State University, USA
The Implications of Vitamin D Status on T Cells, the Microbiome and Crohn’s Disease


Friday, January 23 | 5:00PM - 7:00PM
Infectious and Non-Infectious Granulomatous Disease
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 3 of 5
R Balfour Balfour Sartor, University of North Carolina - Chapel Hill, USA
Granulomatous Enterocolitis and Inflammation in Crohn's Disease: Intersection of Functionally Abnormal Bacteria and Defective Innate and Adaptive Immune Responses


Friday, January 23 | 5:00PM - 7:00PM
Infectious and Non-Infectious Granulomatous Disease
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 4 of 5
Andreea Geamanu, Wayne State University, USA
Short Talk: Metabolomics Links Alterations in Fatty Acid Metabolism, Inflammation and Gut Microbiota in Sarcoidosis


Friday, January 23 | 5:00PM - 7:00PM
Infectious and Non-Infectious Granulomatous Disease
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 5 of 5
Damien J.C. Montamat-Sicotte, McGill Research Institute RI-MUHC, Canada
Short Talk: NOD2: Innate Immunity, Bacterial Infection and Chronic Inflammation


Saturday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Saturday, January 24 | 8:00AM - 11:30AM
Pathogenic Mechanisms in Chronic Granulomatous Disease (Join
t)

Room: Sweeney Ballroom A-D

Speaker 1 of 8
* Vishva M. Dixit, Genentech, Inc., USA

Saturday, January 24 | 8:00AM - 11:30AM
Pathogenic Mechanisms in Chronic Granulomatous Disease (Join
t)

Room: Sweeney Ballroom A-D

Speaker 2 of 8
JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Heterogeneity: Global and Local

Saturday, January 24 | 8:00AM - 11:30AM
Pathogenic Mechanisms in Chronic Granulomatous Disease (Join
t)

Room: Sweeney Ballroom A-D

Speaker 3 of 8
Gilla Kaplan, University of Cape Town, South Africa
Lesion-Specific Immune Activation in Granulomas of Patients with Pulmonary Tuberculosis

Saturday, January 24 | 8:00AM - 11:30AM
Pathogenic Mechanisms in Chronic Granulomatous Disease (Join
t)

Room: Sweeney Ballroom A-D

Speaker 4 of 8
Thomas A. Wynn, Pfizer, USA
Mechanisms of Fibrosis

Saturday, January 24 | 8:00AM - 11:30AM
Pathogenic Mechanisms in Chronic Granulomatous Disease (Join
t)

Room: Sweeney Ballroom A-D

Speaker 5 of 8
Lalita Ramakrishnan, University of Cambridge, UK
Mechanisms and Consequences of Tuberculous Granuloma Necrosis

Saturday, January 24 | 8:00AM - 11:30AM
Pathogenic Mechanisms in Chronic Granulomatous Disease (Join
t)

Room: Sweeney Ballroom A-D

Speaker 6 of 8
Shahin Shafiani, Center for Infectious Disease Research, USA
Short Talk: Foxp3+ Regulatory T Cells Are Host-Protective during Chronic Tuberculosis and Promote a Pathogen-Specific Immune Response

Saturday, January 24 | 8:00AM - 11:30AM
Pathogenic Mechanisms in Chronic Granulomatous Disease (Join
t)

Room: Sweeney Ballroom A-D

Speaker 7 of 8
Philana Ling Lin, University of Pittsburgh, USA
Short Talk: Spatial Patterns of Granuloma Development Differ between Infection and Reactivation

Saturday, January 24 | 8:00AM - 11:30AM
Pathogenic Mechanisms in Chronic Granulomatous Disease (Join
t)

Room: Sweeney Ballroom A-D

Speaker 8 of 8
Igor B. Kramnik, Boston University, USA
Short Talk: Necrosis in Granulomas: Mechanism and Therapeutic Approaches

Saturday, January 24 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney Ballroom Foyer


Saturday, January 24 | 11:00AM - 5:00PM
On Own for Lunch


Saturday, January 24 | 11:30AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakouts


Saturday, January 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakouts


Saturday, January 24 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom Foyer


Saturday, January 24 | 5:00PM - 7:00PM
Bacterial Interactions with Host Cells
Room: Sweeney Ballroom A-D
Mycobacterium tuberculosis interactions with host
Speaker 1 of 5
* Jennifer Philips, Washington University School of Medicine, USA

Saturday, January 24 | 5:00PM - 7:00PM
Bacterial Interactions with Host Cells
Room: Sweeney Ballroom A-D
Mycobacterium tuberculosis interactions with host
Speaker 2 of 5
Sarah M. Fortune, Harvard TH Chan School of Public Health, USA
Dissecting Bacterial Survival, Replication and Mutation in the Host Environment

Saturday, January 24 | 5:00PM - 7:00PM
Bacterial Interactions with Host Cells
Room: Sweeney Ballroom A-D
Mycobacterium tuberculosis interactions with host
Speaker 3 of 5
W. Henry Boom, Case Western Reserve University, USA
Evasion of T Cell Immunity by Mycobacterium tuberculosis

Saturday, January 24 | 5:00PM - 7:00PM
Bacterial Interactions with Host Cells
Room: Sweeney Ballroom A-D
Mycobacterium tuberculosis interactions with host
Speaker 4 of 5
Christopher M. Sassetti, University of Massachusetts Medical School, USA
Systematic Genetic Approaches to Understand TB Pathogenesis

Saturday, January 24 | 5:00PM - 7:00PM
Bacterial Interactions with Host Cells
Room: Sweeney Ballroom A-D
Mycobacterium tuberculosis interactions with host
Speaker 5 of 5
Jordi B. Torrelles, Ohio State University, USA
Short Talk: Lung Mucosa Lining Fluid Modifies Mycobacterium tuberculosis to Reprogram Neutrophil Killing Mechanisms to Preserve the Anti-Inflammatory Integrity of the Lung

Saturday, January 24 | 5:00PM - 7:00PM
Role of Myeloid Cells in Granuloma Formation
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 1 of 5
* P'ng Loke, New York University School of Medicine, USA


Saturday, January 24 | 5:00PM - 7:00PM
Role of Myeloid Cells in Granuloma Formation
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 2 of 5
Peter J. Murray, Max-Planck-Institut für Biochemie, Germany
Amino Acid Metabolism by Innate Immune Cells in Granulomatous Inflammation


Saturday, January 24 | 5:00PM - 7:00PM
Role of Myeloid Cells in Granuloma Formation
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 3 of 5
Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Langerhans Cell Histiocytosis, a Pediatric Granulomatous Disease


Saturday, January 24 | 5:00PM - 7:00PM
Role of Myeloid Cells in Granuloma Formation
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 4 of 5
Vishva M. Dixit, Genentech, Inc., USA
Necroptosis - Role in Inflammation


Saturday, January 24 | 5:00PM - 7:00PM
Role of Myeloid Cells in Granuloma Formation
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 5 of 5
Keke C. Fairfax, University of Utah, USA
Short Talk: Schistosoma mansoni Infection Induces Anti-Atherogenic Transcriptional Changes in Hepatic Macrophages


Saturday, January 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts
No registration fees are used to fund alcohol served at this function.

Saturday, January 24 | 7:30PM - 10:00PM
Poster Session 2
Room: Sweeney F, Main Level Breakouts


Sunday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Sunday, January 25 | 8:00AM - 11:15AM
Risk of TB Disease
Room: Sweeney Ballroom A-D
Factors that influence risk of disease
Speaker 1 of 7
* Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands

Sunday, January 25 | 8:00AM - 11:15AM
Risk of TB Disease
Room: Sweeney Ballroom A-D
Factors that influence risk of disease
Speaker 2 of 7
Thomas J. Scriba, University of Cape Town, South Africa
Prospective Correlates of Risk of TB Disease


Sunday, January 25 | 8:00AM - 11:15AM
Risk of TB Disease
Room: Sweeney Ballroom A-D
Factors that influence risk of disease
Speaker 3 of 7
Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA
Inflammatory Cytokine Networks during TB

Sunday, January 25 | 8:00AM - 11:15AM
Risk of TB Disease
Room: Sweeney Ballroom A-D
Factors that influence risk of disease
Speaker 4 of 7
January Weiner, Max Planck Institute of Infection Biology, Germany
TB Biomarkers Across Cohorts and Sample Types

Sunday, January 25 | 8:00AM - 11:15AM
Risk of TB Disease
Room: Sweeney Ballroom A-D
Factors that influence risk of disease
Speaker 5 of 7
Joel D. Ernst, University of California, San Francisco, USA
Antigen Conservation and Diversity in Human Tuberculosis

Sunday, January 25 | 8:00AM - 11:15AM
Risk of TB Disease
Room: Sweeney Ballroom A-D
Factors that influence risk of disease
Speaker 6 of 7
Rustin Lovewell, University of Massachusetts Medical School, USA
Short Talk: The Role of Neutrophils in Progressive Tuberculosis

Sunday, January 25 | 8:00AM - 11:15AM
Risk of TB Disease
Room: Sweeney Ballroom A-D
Factors that influence risk of disease
Speaker 7 of 7
Diane Joyce Ordway, Colorado State University, USA
Short Talk: BCG Efficacy in Guinea Pigs Naturally Exposed to Patients with Tuberculosis

Sunday, January 25 | 8:00AM - 11:00AM
Granulomas Associated with Type-2 Immunity
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 1 of 6
* Padmini Salgame, Rutgers University, USA


Sunday, January 25 | 8:00AM - 11:00AM
Granulomas Associated with Type-2 Immunity
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 2 of 6
Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolic Reprogramming of Myeloid Cells during Granuloma Formation


Sunday, January 25 | 8:00AM - 11:00AM
Granulomas Associated with Type-2 Immunity
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 3 of 6
William C. Gause, Rutgers New Jersey Medical School, USA
Regulation of Type-2 Inflammation and Pathology in the Lung and Gut during Nematode Infection


Sunday, January 25 | 8:00AM - 11:00AM
Granulomas Associated with Type-2 Immunity
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 4 of 6
P'ng Loke, New York University School of Medicine, USA
Alternatively Activated Macrophages during Granuloma Formation in Schistosomiasis


Sunday, January 25 | 8:00AM - 11:00AM
Granulomas Associated with Type-2 Immunity
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 5 of 6
Michael H. Hsieh, Children's National Medical Center, USA
Type-2 Granulomas and Bladder Cancer


Sunday, January 25 | 8:00AM - 11:00AM
Granulomas Associated with Type-2 Immunity
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 6 of 6
Jessica C. Jang, University of California, Riverside, USA
Short Talk: Human Resistin Is Induced in Multiple Helminth Infections and Promotes Proinflammatory Cytokines and Monocyte-Rich Lung Granulomas


Sunday, January 25 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney Ballroom Foyer


Sunday, January 25 | 11:15AM - 1:00PM
Poster Setup
Room: Sweeney F, Main Level Breakouts


Sunday, January 25 | 11:15AM - 5:00PM
On Own for Lunch


Sunday, January 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Sweeney F, Main Level Breakouts


Sunday, January 25 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom Foyer


Sunday, January 25 | 5:00PM - 7:00PM
B Cells Responses to TB
Room: Sweeney Ballroom A-D
The neglected lymphocyte in TB
Speaker 1 of 5
* Shabaana A. Khader, Washington University School of Medicine, USA

Sunday, January 25 | 5:00PM - 7:00PM
B Cells Responses to TB
Room: Sweeney Ballroom A-D
The neglected lymphocyte in TB
Speaker 2 of 5
John R. Chan, Albert Einstein College of Medicine, USA
B Cells Promote Granulomatous Inflammation during Chronic Mycobacterium tuberculosis Infection

Sunday, January 25 | 5:00PM - 7:00PM
B Cells Responses to TB
Room: Sweeney Ballroom A-D
The neglected lymphocyte in TB
Speaker 3 of 5
Andrea M. Cooper, University of Leicester, UK
The Role of B Cells in Defining T Cell Location in TB

Sunday, January 25 | 5:00PM - 7:00PM
B Cells Responses to TB
Room: Sweeney Ballroom A-D
The neglected lymphocyte in TB
Speaker 4 of 5
Galit Alter, MIT and Harvard University, USA
A Case for Antibody Fc-Effector Function in Tb Containment

Sunday, January 25 | 5:00PM - 7:00PM
B Cells Responses to TB
Room: Sweeney Ballroom A-D
The neglected lymphocyte in TB
Speaker 5 of 5
Alan Bénard, Institut de Pharmacologie et de Biologie Structurale, France
Short Talk: B Cells Modulate Inflammation during Mycobacterium tuberculosis Infection in a MyD88- and Type I Interferon-Dependent Manner

Sunday, January 25 | 5:00PM - 7:00PM
Granulomatous Diseases of the Lung
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 1 of 5
* Daniel L. Barber, NIAID, National Institutes of Health, USA


Sunday, January 25 | 5:00PM - 7:00PM
Granulomatous Diseases of the Lung
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 2 of 5
Randall J. Basaraba, Colorado State University, USA
Granuloma-Targeted Therapy in the Treatment of Tuberculosis


Sunday, January 25 | 5:00PM - 7:00PM
Granulomatous Diseases of the Lung
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 3 of 5
Andrew P. Fontenot, University of Colorado Denver, USA
Gene-Environment Interactions and the Development of Chronic Beryllium Disease


Sunday, January 25 | 5:00PM - 7:00PM
Granulomatous Diseases of the Lung
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 4 of 5
Luigina Romani, University di Perugia, Italy
Chronic Inflammation in Fungal Diseases: From Basic Science to Therapeutic Intervention


Sunday, January 25 | 5:00PM - 7:00PM
Granulomatous Diseases of the Lung
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 5 of 5
Bryce C. Asay, Colorado State University, USA
Short Talk: Heterogeneity in Lesion Types in C3HeB/FeJ Mice Is Modulated by Specific Characteristics of the Mycobacterium tuberculosis Strain Used


Sunday, January 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts
No registration fees are used to fund alcohol served at this function.

Sunday, January 25 | 7:30PM - 10:00PM
Poster Session 3
Room: Sweeney F, Main Level Breakouts


Monday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Sweeney F, Main Level Breakouts


Monday, January 26 | 8:00AM - 11:15AM
Protective Immunity and Vaccines
Room: Sweeney Ballroom A-D
Protection against TB
Speaker 1 of 7
* Thomas Evans, TomegaVax, USA

Monday, January 26 | 8:00AM - 11:15AM
Protective Immunity and Vaccines
Room: Sweeney Ballroom A-D
Protection against TB
Speaker 2 of 7
Denise Kirschner, University of Michigan, USA
A Novel Two-Pronged Approach to Biomarker Discovery in Tuberculosis

Monday, January 26 | 8:00AM - 11:15AM
Protective Immunity and Vaccines
Room: Sweeney Ballroom A-D
Protection against TB
Speaker 3 of 7
Willem A. Hanekom, Bill & Melinda Gates Foundation, USA
Vaccines against TB: Where Are We Going?

Monday, January 26 | 8:00AM - 11:15AM
Protective Immunity and Vaccines
Room: Sweeney Ballroom A-D
Protection against TB
Speaker 4 of 7
D. Branch Moody, Brigham and Women's Hospital, USA
Building Technology-Based T Cell Response to Non-Polymorphic CD1 Proteins

Monday, January 26 | 8:00AM - 11:15AM
Protective Immunity and Vaccines
Room: Sweeney Ballroom A-D
Protection against TB
Speaker 5 of 7
Robert A. Seder, NIAID, National Institutes of Health, USA
What Is Needed to Protect Against TB?

Monday, January 26 | 8:00AM - 11:15AM
Protective Immunity and Vaccines
Room: Sweeney Ballroom A-D
Protection against TB
Speaker 6 of 7
Stephen M. Carpenter, Regeneron Pharmaceuticals, USA
Short Talk: Heavily-Armed but Outnumbered: A Selective Loss of Memory CD8+ T Cells during Tuberculosis May Eclipse the Benefit of Vaccination

Monday, January 26 | 8:00AM - 11:15AM
Protective Immunity and Vaccines
Room: Sweeney Ballroom A-D
Protection against TB
Speaker 7 of 7
Guangwu Xu, Vaccine & Gene Therapy Inst, and the Oregon National Primate Research Ctr, OHSU, USA
Short Talk: Cytomegalovirus Vector-Based Tuberculosis Vaccines Provide Superior Protection to BCG after Intra-Bronchial mTb Challenge of Indian-Origin Rhesus macaques

Monday, January 26 | 8:00AM - 11:15AM
Computational Modeling, Imaging and Treatment
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 1 of 7
* Andrew P. Fontenot, University of Colorado Denver, USA


Monday, January 26 | 8:00AM - 11:15AM
Computational Modeling, Imaging and Treatment
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 2 of 7
Annemarie H. Meijer, Leiden University, Netherlands
In vivo Study of Anti-Mycobacterial Autophagy and Granuloma Formation in the Zebrafish Model


Monday, January 26 | 8:00AM - 11:15AM
Computational Modeling, Imaging and Treatment
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 3 of 7
Ronald N. Germain, NIAID, National Institutes of Health, USA
Live Imaging Anti-Mycobacterial Immunity


Monday, January 26 | 8:00AM - 11:15AM
Computational Modeling, Imaging and Treatment
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 4 of 7
Matyas Sandor, University of Wisconsin, USA
Mycobacterial Granuloma Dynamics: Repopulation, Reformation and Cellular Traffic


Monday, January 26 | 8:00AM - 11:15AM
Computational Modeling, Imaging and Treatment
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 5 of 7
Steven M. Holland, NIAID, National Institutes of Health, USA
Genetics and Treatment of Chronic Granulomatous Disease


Monday, January 26 | 8:00AM - 11:15AM
Computational Modeling, Imaging and Treatment
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 6 of 7
Elsje Pienaar, University of Michigan, USA
Short Talk: Interplay between Mycobacterial Metabolism and Granuloma Dynamics in Tuberculosis


Monday, January 26 | 8:00AM - 11:15AM
Computational Modeling, Imaging and Treatment
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 7 of 7
David M. Tobin, Duke University School of Medicine, USA
Short Talk: Interception of Host Angiogenic Signaling Limits Mycobacterial Growth


Monday, January 26 | 9:20AM - 9:40AM
Coffee Break
Room: Sweeney Ballroom Foyer


Monday, January 26 | 11:15AM - 2:30PM
On Own for Lunch


Monday, January 26 | 2:30PM - 4:30PM
Workshop 2: Clinical and Translational
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 1 of 6
* David M. Tobin, Duke University School of Medicine, USA


Monday, January 26 | 2:30PM - 4:30PM
Workshop 2: Clinical and Translational
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 2 of 6
Delia Goletti, National Institute for Infectious Diseases, Italy
Can Blood or Urine IP-10 Discriminate between Active and Non Active Tuberculosis in Children from High Endemic Areas?


Monday, January 26 | 2:30PM - 4:30PM
Workshop 2: Clinical and Translational
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 3 of 6
Lobelia Samavati, Wayne State University School of Medicine, USA
Development of a Sarcoidosis Library to Detect Sarcoidosis and Tuberculosis by a Panel of Novel Biomarkers


Monday, January 26 | 2:30PM - 4:30PM
Workshop 2: Clinical and Translational
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 4 of 6
Daniel Torocsik, University of Debrecen, Hungary
Immunohistochemical Characterization of FXIII-A+ Cells in Non-Infectious Granulomatous Skin Lesions


Monday, January 26 | 2:30PM - 4:30PM
Workshop 2: Clinical and Translational
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 5 of 6
Javeed Ali Shah, University of Washington, USA
TOLLIP Variants Are Associated with Susceptibility to Leprosy and Dermal Expression of TOLLIP and IL-1Ra in Nepal


Monday, January 26 | 2:30PM - 4:30PM
Workshop 2: Clinical and Translational
This session is from Granulomas
Room: Coronado / DeVargas

Speaker 6 of 6
Ho Namkoong, Keio University School of Medicine, Japan
Clarithromycin Expands CD11b+Gr-1+Cells to Ameliorate Post-Influenza Pneumococcal Pneumonia


Monday, January 26 | 4:30PM - 5:00PM
Coffee Available
Room: Sweeney Ballroom Foyer


Monday, January 26 | 5:00PM - 7:00PM
TB and Co-Morbidities (Joint)
Room: Sweeney Ballroom A-D
Interactions of TB with other diseases
Speaker 1 of 5
* Willem A. Hanekom, Bill & Melinda Gates Foundation, USA

Monday, January 26 | 5:00PM - 7:00PM
TB and Co-Morbidities (Joint)
Room: Sweeney Ballroom A-D
Interactions of TB with other diseases
Speaker 2 of 5
Padmini Salgame, Rutgers University, USA
TB and Worms

Monday, January 26 | 5:00PM - 7:00PM
TB and Co-Morbidities (Joint)
Room: Sweeney Ballroom A-D
Interactions of TB with other diseases
Speaker 3 of 5
Hardy Kornfeld, University of Massachusetts Medical School, USA
TB and Diabetes

Monday, January 26 | 5:00PM - 7:00PM
TB and Co-Morbidities (Joint)
Room: Sweeney Ballroom A-D
Interactions of TB with other diseases
Speaker 4 of 5
Jovvian George Parakkal, New York Blood Center-LFKRI, USA
Short Talk: Influence of Helminth Infections on the Innate and Adaptive Immune Responses to Pulmonary Tuberculosis

Monday, January 26 | 5:00PM - 7:00PM
TB and Co-Morbidities (Joint)
Room: Sweeney Ballroom A-D
Interactions of TB with other diseases
Speaker 5 of 5
Robert J. Wilkinson, University of Cape Town, South Africa
Talk Title to be Announced

Monday, January 26 | 7:00PM - 7:30PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Sweeney Ballroom A-D


Monday, January 26 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Sweeney F, Main Level Breakouts
No registration fees are used to fund alcohol served at this function.

Monday, January 26 | 8:00PM - 11:00PM
Entertainment
Room: Sweeney F, Main Level Breakouts
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Monday, January 26 | 8:00PM - 11:00PM
Cash Bar
Room: Sweeney F, Main Level Breakouts


Tuesday, January 27 | 10:25AM - 10:25AM
Departure


*Session Chair.