Web Desc
Cell Death Signaling in Cancer and the Immune System
Organizer(s): Gustavo Amarante-Mendes, Douglas R. Green and Kim Newton
Date: October 28 - November 02, 2014
Location: Casa Grande Hotel, Guarujá, Sao Paulo, Brazil
Organized in collaboration with the São Paulo Research Foundation (FAPESP) and the National Council for Scientific and Technological Development (CNPq) - Brazil. Sponsored by AbbVie Inc., Genentech, Inc. H3 Biomedicine Inc. and TESARO, Inc.
Summary of Meeting:
Cellular decisions to live or die are fundamental to development and adult homeostasis, playing roles in a wide variety of physiological and pathological processes. These include cancer, degenerative disease, innate and adaptive immunity, ischemia-reperfusion injury and infectious disease. Over the past decades, the fundamental molecular mechanisms underlying one form of cell death, apoptosis, have been largely defined. Other forms of cell death, such as programmed necrosis or autophagic cell death, are not as well understood. In this meeting, the pathways that impact on a cell’s decision to live or die will be presented in the context of physiology and disease, and ways to influence that decision therapeutically will be explored. The consequence of cell death for the body is also of great interest, as the clearance of dying cells impacts on other physiological processes. The successful elucidation of the molecular pathways controlling and mediating apoptosis has come to fruition as agents for cancer and other therapies are entering the clinic. Similar promise exists for other forms of cell death as our knowledge of these advances. In addition, we are beginning to understand how processes relating to cell death and survival play roles in other biological processes, such as the secretion of cytokines and the response to infection. This meeting brings together researchers in the fields of cell death and survival from around the world. As the study of cell death moves beyond the central mechanisms of apoptosis to wider issues of regulation and other forms of cell death, this vibrant area of research widens its influence and importance for human health and disease.
Global Health Travel Award Deadline: July 10 2014
Scholarship Deadline: June 26 2014
Discounted Abstract Deadline: June 26 2014
Abstract Deadline: July 29 2014
Discounted Registration Deadline: August 28 2014
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AbbVie Inc.Genentech, Inc.H3 Biomedicine Inc.National Council for Scientific and Technological Development (CNPq) - BrazilSão Paulo Research Foundation (FAPESP) - BrazilTESARO, Inc.
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.


FAPESP Keystone Symposia Travel Awards
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Tuesday, October 28 | 4:00PM - 8:00PM
Arrival and Registration
Room: Imperial Ballroom Foyer


Tuesday, October 28 | 6:00PM - 7:00PM
Welcome Mixer
Room: Imperial Ballroom Terrace


Wednesday, October 29 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Wednesday, October 29 | 8:30AM - 9:30AM
Keynote Address
Room: Imperial Ballroom

Speaker 2 of 2
Vishva M. Dixit, Genentech, Inc., USA
Interplay between NOD Sensors that Mediated Pyroptosis

Wednesday, October 29 | 8:30AM - 9:30AM
Keynote Address
Room: Imperial Ballroom

Speaker 1 of 2
* Douglas R. Green, St. Jude Children's Research Hospital, USA

Wednesday, October 29 | 9:30AM - 12:00PM
Cell Death Signaling I
Room: Imperial Ballroom

Speaker 5 of 5
Douglas R. Green, St. Jude Children's Research Hospital, USA
How Cells Survive: Single Cell Analysis Reveals Properties of Non-Genetic Apoptosis Resistance

Wednesday, October 29 | 9:30AM - 12:00PM
Cell Death Signaling I
Room: Imperial Ballroom

Speaker 4 of 5
Stefan J. Riedl, Sanford-Burnham Medical Research Institute, USA
Short Talk: Structure and Mechanism: Death Domains in the Regulation of Immunity and Cancer

Wednesday, October 29 | 9:30AM - 12:00PM
Cell Death Signaling I
Room: Imperial Ballroom

Speaker 3 of 5
Mohanish Deshmukh, University of North Carolina at Chapel Hill, USA
How Cells Evade Apoptosis: From Neurons to Cancer

Wednesday, October 29 | 9:30AM - 12:00PM
Cell Death Signaling I
Room: Imperial Ballroom

Speaker 2 of 5
Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
A Toolbox of Highly Selective Caspase Chemical Reagents

Wednesday, October 29 | 9:30AM - 12:00PM
Cell Death Signaling I
Room: Imperial Ballroom

Speaker 1 of 5
* Seamus J. Martin, Trinity College Dublin, Ireland

Wednesday, October 29 | 10:10AM - 10:30AM
Coffee Break
Room: Imperial Ballroom Terrace


Wednesday, October 29 | 12:00PM - 2:30PM
On Own for Lunch


Wednesday, October 29 | 12:00PM - 1:00PM
Poster Setup
Room: Imperial Ballroom


Wednesday, October 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Imperial Ballroom


Wednesday, October 29 | 2:30PM - 4:30PM
Workshop 1: Cancer
Room: Imperial Ballroom

Speaker 9 of 9
Fabien Llambi, St. Jude Children's Research Hospital, USA
BOK is a Pro-Apoptotic Effector Protein Regulated by the Ubiquitin-Proteasome System

Wednesday, October 29 | 2:30PM - 4:30PM
Workshop 1: Cancer
Room: Imperial Ballroom

Speaker 8 of 9
Gabriel Ichim, UK
Limited Mitochondrial Permeabilisation Causes DNA-Damage and Genomic Instability in the Absence of Cell Death

Wednesday, October 29 | 2:30PM - 4:30PM
Workshop 1: Cancer
Room: Imperial Ballroom

Speaker 7 of 9
Stephen E. Girardin, University of Toronto, Canada
The Mitochondrial Protein NLRX1 Controls the Balance between Extrinsic and Intrinsic Apoptosis

Wednesday, October 29 | 2:30PM - 4:30PM
Workshop 1: Cancer
Room: Imperial Ballroom

Speaker 6 of 9
Hetal Brahmbhatt, McMaster University, Canada
Identification and Characterization of Small Molecules that Enhance the Pro-Apoptotic Activity of Bax

Wednesday, October 29 | 2:30PM - 4:30PM
Workshop 1: Cancer
Room: Imperial Ballroom

Speaker 5 of 9
Yannick Böge, University Hospital Zürich, Switzerland
An Apoptosis-Driven Pathway to Hepatocarcinogenesis

Wednesday, October 29 | 2:30PM - 4:30PM
Workshop 1: Cancer
Room: Imperial Ballroom

Speaker 4 of 9
Nga Lam, Walter and Eliza Hall Institute, Australia
Understanding the Role of Bcl-G in Cell Death Signaling And Colorectal Cancer

Wednesday, October 29 | 2:30PM - 4:30PM
Workshop 1: Cancer
Room: Imperial Ballroom

Speaker 3 of 9
Keehoon Jung, Harvard Medical School, Massachusetts General Hospital, USA
Targeting the Immune Microenvironment to Improve Colorectal Cancer Treatment

Wednesday, October 29 | 2:30PM - 4:30PM
Workshop 1: Cancer
Room: Imperial Ballroom

Speaker 2 of 9
Peter Huebener, University Hospital Hamburg-Eppendorf, Germany
HMGB1 Links Chronic Injury and Cancer in the Liver

Wednesday, October 29 | 2:30PM - 4:30PM
Workshop 1: Cancer
Room: Imperial Ballroom

Speaker 1 of 9
* David W. Andrews, Sunnybrook Research Institute, Canada

Wednesday, October 29 | 4:30PM - 5:00PM
Coffee Available
Room: Imperial Ballroom Terrace


Wednesday, October 29 | 5:00PM - 7:00PM
Cell Death Signaling II
Room: Imperial Ballroom

Speaker 1 of 5
* Shigekazu Nagata, IFReC, Osaka University, Japan

Wednesday, October 29 | 5:00PM - 7:00PM
Cell Death Signaling II
Room: Imperial Ballroom

Speaker 2 of 5
Marion MacFarlane, MRC Toxicology Unit, UK
c-FLIP-Mediated Regulation of Caspase-8 DED Chain Assembly Determines Cell Fate

Wednesday, October 29 | 5:00PM - 7:00PM
Cell Death Signaling II
Room: Imperial Ballroom

Speaker 3 of 5
Peter Vandenabeele, VIB, Ghent University, Belgium
Necroptosis versus Apoptosis

Wednesday, October 29 | 5:00PM - 7:00PM
Cell Death Signaling II
Room: Imperial Ballroom

Speaker 4 of 5
Francis Ka-Ming Chan, Duke University, USA
Playing with Fire: Necroptosis-Dependent and Independent Roles of RIPK3 in Inflammation

Wednesday, October 29 | 5:00PM - 7:00PM
Cell Death Signaling II
Room: Imperial Ballroom

Speaker 5 of 5
Silvia Alvarez-Diaz, Walter and Eliza Hall Institute, Australia
Short Talk: MLKL Plays a Critical Role Inducing Necroptosis within a Physiological Context

Wednesday, October 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Imperial Ballroom Terrace


Wednesday, October 29 | 7:30PM - 10:00PM
Poster Session 1
Room: Imperial Ballroom


Thursday, October 30 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Thursday, October 30 | 8:30AM - 11:45AM
Cell Death and Cancer I
Room: Imperial Ballroom

Speaker 1 of 7
* Karen H. Vousden, Francis Crick Institute, UK

Thursday, October 30 | 8:30AM - 11:45AM
Cell Death and Cancer I
Room: Imperial Ballroom

Speaker 2 of 7
Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
How Does p53 Prevent Cancer?

Thursday, October 30 | 8:30AM - 11:45AM
Cell Death and Cancer I
Room: Imperial Ballroom

Speaker 3 of 7
David W. Andrews, Sunnybrook Research Institute, Canada
Regulation of Mitochondrial Membrane Permeabilization by Bcl-2 Family Proteins

Thursday, October 30 | 8:30AM - 11:45AM
Cell Death and Cancer I
Room: Imperial Ballroom

Speaker 4 of 7
Axel Witt, University Hospital Cologne, Germany
Short Talk: IAP Antagonization Induces Inflammatory Destruction of Vasculature Endothelium and Inhibits Tumor Growth

Thursday, October 30 | 8:30AM - 11:45AM
Cell Death and Cancer I
Room: Imperial Ballroom

Speaker 5 of 7
Gerry Melino, University of Rome ‘Tor Vergata’, Italy
Control of Cell Fate by miRNA

Thursday, October 30 | 8:30AM - 11:45AM
Cell Death and Cancer I
Room: Imperial Ballroom

Speaker 6 of 7
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Cellular Cooperation in Normal Tissues and Tumors

Thursday, October 30 | 8:30AM - 11:45AM
Cell Death and Cancer I
Room: Imperial Ballroom

Speaker 7 of 7
Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Short Talk: Mcl-1 Inhibitors for the Treatment of TNBC and Other Cancers

Thursday, October 30 | 9:50AM - 10:10AM
Coffee Break
Room: Imperial Ballroom Terrace


Thursday, October 30 | 11:45AM - 1:00PM
Poster Setup
Room: Imperial Ballroom


Thursday, October 30 | 11:45AM - 2:30PM
On Own for Lunch


Thursday, October 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Imperial Ballroom


Thursday, October 30 | 2:30PM - 4:30PM
Workshop 2: Host Defense
Room: Imperial Ballroom

Speaker 1 of 9
* Petr Broz, University of Lausanne, Switzerland

Thursday, October 30 | 2:30PM - 4:30PM
Workshop 2: Host Defense
Room: Imperial Ballroom

Speaker 2 of 9
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

Thursday, October 30 | 2:30PM - 4:30PM
Workshop 2: Host Defense
Room: Imperial Ballroom

Speaker 3 of 9
Goutam Gupta, Los Alamos National Laboratory, USA
Preventing Host Cell Death by Engineering of Novel Innate Immune Defense

Thursday, October 30 | 2:30PM - 4:30PM
Workshop 2: Host Defense
Room: Imperial Ballroom

Speaker 4 of 9
Luciana Paroneto Medina, Institute of Biomedical Sciences, University of São Paulo, Brazil
PGE2 as a Regulator of Experimental Autoimmune Encephalomyelitis (EAE)

Thursday, October 30 | 2:30PM - 4:30PM
Workshop 2: Host Defense
Room: Imperial Ballroom

Speaker 5 of 9
Maria Andree, University of Cologne, Germany
BID-Dependent Release of Mitochondrial SMAC Dampens XIAP-Mediated Immunity Against Shigella

Thursday, October 30 | 2:30PM - 4:30PM
Workshop 2: Host Defense
Room: Imperial Ballroom

Speaker 6 of 9
Dmitry M. Shayakhmetov, Emory University, USA
The Identification of the Novel Physiologically-Regulated Necrotic Cell Death Pathway Mediated by the Interferon-Regulatory Factor 3 (IRF3)

Thursday, October 30 | 2:30PM - 4:30PM
Workshop 2: Host Defense
Room: Imperial Ballroom

Speaker 7 of 9
Eugenio D. Hottz, Oswaldo Cruz Foundation, Brazil
Activation of Inflammasome and Cell Death Pathways in Platelets Modulate Inflammatory Responses in Dengue

Thursday, October 30 | 2:30PM - 4:30PM
Workshop 2: Host Defense
Room: Imperial Ballroom

Speaker 8 of 9
Bernardo S. Franklin, University of Bonn, Germany
The Extracellular Functions of the Inflammasomes

Thursday, October 30 | 2:30PM - 4:30PM
Workshop 2: Host Defense
Room: Imperial Ballroom

Speaker 9 of 9
Jennifer Martinez, NIEHS, National Institutes of Health, USA
LC3-Associated Phagocytosis as a Critical Regulator of Inflammation

Thursday, October 30 | 4:30PM - 5:00PM
Coffee Available
Room: Imperial Ballroom Terrace


Thursday, October 30 | 5:00PM - 7:00PM
Cell Death and Cancer II
Room: Imperial Ballroom

Speaker 1 of 5
* Simone Fulda, University Hospital Frankfurt, Germany

Thursday, October 30 | 5:00PM - 7:00PM
Cell Death and Cancer II
Room: Imperial Ballroom

Speaker 2 of 5
Gerard I. Evan, University of Cambridge, UK
Killing Cancers without Killing Normal Tissues

Thursday, October 30 | 5:00PM - 7:00PM
Cell Death and Cancer II
Room: Imperial Ballroom

Speaker 3 of 5
Karen H. Vousden, Francis Crick Institute, UK
Metabolic Control of Cancer Cell Fate Decisions

Thursday, October 30 | 5:00PM - 7:00PM
Cell Death and Cancer II
Room: Imperial Ballroom

Speaker 4 of 5
Anthony G. Letai, Dana-Farber Cancer Institute, USA
Kicking Cancer Right in the Mitochondria

Thursday, October 30 | 5:00PM - 7:00PM
Cell Death and Cancer II
Room: Imperial Ballroom

Speaker 5 of 5
Andreas Bergmann, University of Massachusetts Medical School, USA
Short Talk: Autophagy Regulates Tissue Overgrowth in a Context-Dependent Manner

Thursday, October 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Imperial Ballroom Terrace


Thursday, October 30 | 7:30PM - 10:00PM
Poster Session 2
Room: Imperial Ballroom


Friday, October 31 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Friday, October 31 | 8:30AM - 11:30AM
Cell Death and Host Defense I
Room: Imperial Ballroom

Speaker 1 of 6
* Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA

Friday, October 31 | 8:30AM - 11:30AM
Cell Death and Host Defense I
Room: Imperial Ballroom

Speaker 2 of 6
Petr Broz, University of Lausanne, Switzerland
Caspase-11 Activation Requires Lysis of Pathogen-Containing Vacuoles by IFN-Induced GTPases

Friday, October 31 | 8:30AM - 11:30AM
Cell Death and Host Defense I
Room: Imperial Ballroom

Speaker 3 of 6
Domagoj Vucic, Genentech, Inc., USA
IAP Proteins Regulate the Formation of Necrosome and Inflammasome Complexes

Friday, October 31 | 8:30AM - 11:30AM
Cell Death and Host Defense I
Room: Imperial Ballroom

Speaker 4 of 6
Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Inflammasome Control of Disease

Friday, October 31 | 8:30AM - 11:30AM
Cell Death and Host Defense I
Room: Imperial Ballroom

Speaker 5 of 6
Karina R. Bortoluci, Federal University of São Paulo, Brazil
Lysosomal Pathway Induced by Cytosolic Flagellin in Cell Death and Immunity

Friday, October 31 | 8:30AM - 11:30AM
Cell Death and Host Defense I
Room: Imperial Ballroom

Speaker 6 of 6
Igor E. Brodsky, University of Pennsylvania, USA
Short Talk: RIPK1 and Caspase-8 Catalytic Activity Mediate Caspase-1 Activation in Response to Pathogen Blockade of Innate Immune Signaling

Friday, October 31 | 9:50AM - 10:10AM
Coffee Break
Room: Imperial Ballroom Terrace


Friday, October 31 | 11:30AM - 1:00PM
Poster Setup
Room: Imperial Ballroom


Friday, October 31 | 11:30AM - 5:00PM
On Own for Lunch


Friday, October 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Imperial Ballroom


Friday, October 31 | 4:30PM - 5:00PM
Coffee Available
Room: Imperial Ballroom Terrace


Friday, October 31 | 5:00PM - 7:00PM
Cell Death and Host Defense II
Room: Imperial Ballroom

Speaker 1 of 5
* Eric H. Baehrecke, University of Massachusetts Medical School, USA

Friday, October 31 | 5:00PM - 7:00PM
Cell Death and Host Defense II
Room: Imperial Ballroom

Speaker 2 of 5
Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Microbiota Control of Infection and Inflammation Induced Pathology

Friday, October 31 | 5:00PM - 7:00PM
Cell Death and Host Defense II
Room: Imperial Ballroom

Speaker 3 of 5
Gustavo P. Amarante-Mendes, Universidade de São Paulo, Brazil
Short Talk: Novel Role for Galectin-1 in CTL Killing

Friday, October 31 | 5:00PM - 7:00PM
Cell Death and Host Defense II
Room: Imperial Ballroom

Speaker 4 of 5
Seamus J. Martin, Trinity College Dublin, Ireland
Cell Death and Inflammation: Revisiting the Danger Model


Friday, October 31 | 5:00PM - 7:00PM
Cell Death and Host Defense II
Room: Imperial Ballroom

Speaker 5 of 5
Avi Ashkenazi, Genentech, Inc., USA
Opposing UPR Signals Converge on DR5 to Control Apoptosis

Friday, October 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Imperial Ballroom Terrace


Friday, October 31 | 7:30PM - 10:00PM
Poster Session 3
Room: Imperial Ballroom


Saturday, November 01 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotel


Saturday, November 01 | 8:30AM - 11:45AM
Consequences of Cell Death
Room: Imperial Ballroom

Speaker 1 of 7
* Peter Vandenabeele, VIB, Ghent University, Belgium

Saturday, November 01 | 8:30AM - 11:45AM
Consequences of Cell Death
Room: Imperial Ballroom

Speaker 2 of 7
Shigekazu Nagata, IFReC, Osaka University, Japan
Exposure of Phosphatidylserine during Apoptosis

Saturday, November 01 | 8:30AM - 11:45AM
Consequences of Cell Death
Room: Imperial Ballroom

Speaker 3 of 7
Kim Newton, Genentech, Inc., USA
Necroptosis Signaling and Inflammation

Saturday, November 01 | 8:30AM - 11:45AM
Consequences of Cell Death
Room: Imperial Ballroom

Speaker 4 of 7
Andrew Oberst, University of Washington, USA
Short Talk: Inflammatory and Immune Responses to Apoptosis and Necroptosis

Saturday, November 01 | 8:30AM - 11:45AM
Consequences of Cell Death
Room: Imperial Ballroom

Speaker 5 of 7
Will Wood, University of Edinburgh, UK
Signal Prioritization: Recognizing Death and Damage in vivo

Saturday, November 01 | 8:30AM - 11:45AM
Consequences of Cell Death
Room: Imperial Ballroom

Speaker 6 of 7
Eric H. Baehrecke, University of Massachusetts Medical School, USA
Inflammatory Signaling, Autophagy and Dying Cell Clearance

Saturday, November 01 | 8:30AM - 11:45AM
Consequences of Cell Death
Room: Imperial Ballroom

Speaker 7 of 7
Linda Julian, Beatson Institute for Cancer Research, UK
Short Talk: Apoptotic Blebbing in Tissue Homeostasis and Cancer

Saturday, November 01 | 9:50AM - 10:10AM
Coffee Break
Room: Imperial Ballroom Terrace


Saturday, November 01 | 11:45AM - 5:00PM
On Own for Lunch


Saturday, November 01 | 4:30PM - 5:00PM
Coffee Available
Room: Imperial Ballroom Terrace


Saturday, November 01 | 5:00PM - 6:15PM
Cell Death Therapies
Room: Imperial Ballroom

Speaker 1 of 3
* Kim Newton, Genentech, Inc., USA

Saturday, November 01 | 5:00PM - 6:15PM
Cell Death Therapies
Room: Imperial Ballroom

Speaker 2 of 3
Simone Fulda, University Hospital Frankfurt, Germany
Novel Opportunities to Target IAP Proteins for Cancer Therapy

Saturday, November 01 | 5:00PM - 6:15PM
Cell Death Therapies
Room: Imperial Ballroom

Speaker 3 of 3
David Ching Huang, Walter and Eliza Hall Institute of Medical Research, Australia
Therapeutically Targeting the Bcl-2-Regulated Cell Survival Pathway

Saturday, November 01 | 6:15PM - 7:15PM
Closing Keynote Address
Room: Imperial Ballroom

Speaker 1 of 2
* Gustavo P. Amarante-Mendes, Universidade de São Paulo, Brazil

Saturday, November 01 | 6:15PM - 7:15PM
Closing Keynote Address
Room: Imperial Ballroom

Speaker 2 of 2
Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Tumor Suppressor and Tumor Maintenance Genes

Saturday, November 01 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Imperial Ballroom


Saturday, November 01 | 8:00PM - 11:00PM
Entertainment
Room: Imperial Ballroom


Saturday, November 01 | 8:00PM - 11:00PM
Cash Bar
Room: Imperial Ballroom


Sunday, November 02 | 10:25AM - 10:25AM
Departure


*Session Chair.